Pub Date : 2024-07-27DOI: 10.23958/ijirms/vol09-i07/1936
Suratsawadee Sinwat, P. Sirisa-ard, C. Nithikathkul
Introduction: Malaria is a tropical disease caused by Plasmodium parasites. The parasite spreads to people through the bite of infected female Anopheles mosquitoes. Malaria occurs mainly in poor, tropical, and subtropical areas of the world. The use of traditional medicine/traditional healers is prominent among populations in low-income countries with malaria infection. This study investigated the use of medicinal plants in the treatment of malaria by traditional healers. As well as studying the chemicals in medicinal plants used in treating malaria. To develop information on traditional medicinal plants used to treat and prevent malaria. Methodology: In-depth interviews were conducted along with observational studies of traditional healers. Results: The results showed that 13 medicinal plants have been used in the treatment of malaria by the folk healers in the study areas. The medicinal plants most common used by folk healers are neem (Azadirachta indica A.Juss.), quinine (Brucea javanica (L.) Merr.), wormwood (Tinospora crispa (L.)), and Eurycoma longifolia Jack. These main medicinal plants have the nourishing, therapeutic and preventive properties for malaria during a journey in the forest. They have been used as analgesic against all kinds of fever such as persistent fever and malaria. Each folk healer has been taught by their ancestors with at least 15 years of experience in healing and taking care of a large number of patients in their community. As these 2 provinces are adjacent to Cambodia, all folk healers can treat malaria even in severe stages such as cerebral malaria, malaria-induced splenic infarction and other similar fever conditions. Conclusion: The active substances or phytochemicals of 5 medicinal plants used in the treatment of malaria were characterized using crude ethanol extracts. Two primary phytochemicals were identified in Azadirachta indica A.Juss. and Ficus Racemosa Linn. which were terpenoids and phenolics, two phytochemicals were identified in Brucea javanica (L.) Merr. which were alkaloids and phenolics while three phytochemicals were identified in Tinospora crispa (L.) and Eurycoma longifolia Jack which were terpenoids, alkaloids and phenolics. For the total alkaloid content in 3 medicinal plants, Brucea javanica (L.) Merr. had highest total alkaloid content of 1.73-1.84%, followed by Tinospora crispa (L.) 1.15-1.59% and Eurycoma longifolia Jack 0.34-0.58%.In conclusion, folk healers in Sa Kaeo Province used medicinal plants gathered from their local community forests, which are found in every district, according to a study on the distribution and density of medicinal plants used in the treatment and prevention of malaria in the province's various districts. These therapeutic plants' coordinates were found using the geographic information system (GIS).
{"title":"Application of Geographic Information System (GIS) and Comparison of Active Substances in Medicinal Plants Used in Malaria Treatment Based on Folk Medicine Wisdom in Sa Kaeo Province","authors":"Suratsawadee Sinwat, P. Sirisa-ard, C. Nithikathkul","doi":"10.23958/ijirms/vol09-i07/1936","DOIUrl":"https://doi.org/10.23958/ijirms/vol09-i07/1936","url":null,"abstract":"Introduction: Malaria is a tropical disease caused by Plasmodium parasites. The parasite spreads to people through the bite of infected female Anopheles mosquitoes. Malaria occurs mainly in poor, tropical, and subtropical areas of the world. The use of traditional medicine/traditional healers is prominent among populations in low-income countries with malaria infection. This study investigated the use of medicinal plants in the treatment of malaria by traditional healers. As well as studying the chemicals in medicinal plants used in treating malaria. To develop information on traditional medicinal plants used to treat and prevent malaria. Methodology: In-depth interviews were conducted along with observational studies of traditional healers. Results: The results showed that 13 medicinal plants have been used in the treatment of malaria by the folk healers in the study areas. The medicinal plants most common used by folk healers are neem (Azadirachta indica A.Juss.), quinine (Brucea javanica (L.) Merr.), wormwood (Tinospora crispa (L.)), and Eurycoma longifolia Jack. These main medicinal plants have the nourishing, therapeutic and preventive properties for malaria during a journey in the forest. They have been used as analgesic against all kinds of fever such as persistent fever and malaria. Each folk healer has been taught by their ancestors with at least 15 years of experience in healing and taking care of a large number of patients in their community. As these 2 provinces are adjacent to Cambodia, all folk healers can treat malaria even in severe stages such as cerebral malaria, malaria-induced splenic infarction and other similar fever conditions. Conclusion: The active substances or phytochemicals of 5 medicinal plants used in the treatment of malaria were characterized using crude ethanol extracts. Two primary phytochemicals were identified in Azadirachta indica A.Juss. and Ficus Racemosa Linn. which were terpenoids and phenolics, two phytochemicals were identified in Brucea javanica (L.) Merr. which were alkaloids and phenolics while three phytochemicals were identified in Tinospora crispa (L.) and Eurycoma longifolia Jack which were terpenoids, alkaloids and phenolics. For the total alkaloid content in 3 medicinal plants, Brucea javanica (L.) Merr. had highest total alkaloid content of 1.73-1.84%, followed by Tinospora crispa (L.) 1.15-1.59% and Eurycoma longifolia Jack 0.34-0.58%.\u0000In conclusion, folk healers in Sa Kaeo Province used medicinal plants gathered from their local community forests, which are found in every district, according to a study on the distribution and density of medicinal plants used in the treatment and prevention of malaria in the province's various districts. These therapeutic plants' coordinates were found using the geographic information system (GIS).","PeriodicalId":14008,"journal":{"name":"International Journal of Innovative Research in Medical Science","volume":"64 22","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141798922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Physical activity is recognized as a supportive care in cancer management. Mobile apps have become a common and effective method of promoting physical activity in cancer. The results presented in this paper come from the mobile app design process at the National Institute of Oncology in Morocco. Objectives: This study aimed to describe the short-term changes in physical activity and quality of life in post-cancer treatment, after participating in this mobile app design process. Methods: Twenty-four post-treatment cancer patients participated in a user-centered design process to create a mobile physical activity application. The data collected was based on self-monitoring and self-assessment. The assessment was requested at the beginning and the end of the participation using the International Physical Activity Questionnaire and the SF-12 questionnaire. Results: The physical activity volume rose from 323 MET-min/week (160–410) in the first evaluation to 540 MET-min/week (460–730) after the mobile app participation. Eight of 11 participants have been moved from a low physical activity level to a moderate level. The physical health score rose from 57 (63-37) to 65 (72-54). The mental health score rose from 57 (63-37) to 65 (72-54). Conclusions: A short-term improvement in physical activity and quality of life was observed in post-treatment cancer patients. However, stronger studies are needed to confirm these results.
{"title":"Mobile App Design Process to Promote Physical Activity in Cancer Care: Findings about Physical Activity and Quality of Life","authors":"Youness Azemmour, Hassan Beddaa, Hamid Chamlal, Fahd Elkhalloufi, Abdeljabbar Rouani, Rachid Fares, Saber Boutayeb","doi":"10.23958/ijirms/vol09-i07/1933","DOIUrl":"https://doi.org/10.23958/ijirms/vol09-i07/1933","url":null,"abstract":"Background: Physical activity is recognized as a supportive care in cancer management. Mobile apps have become a common and effective method of promoting physical activity in cancer. The results presented in this paper come from the mobile app design process at the National Institute of Oncology in Morocco. Objectives: This study aimed to describe the short-term changes in physical activity and quality of life in post-cancer treatment, after participating in this mobile app design process. Methods: Twenty-four post-treatment cancer patients participated in a user-centered design process to create a mobile physical activity application. The data collected was based on self-monitoring and self-assessment. The assessment was requested at the beginning and the end of the participation using the International Physical Activity Questionnaire and the SF-12 questionnaire. Results: The physical activity volume rose from 323 MET-min/week (160–410) in the first evaluation to 540 MET-min/week (460–730) after the mobile app participation. Eight of 11 participants have been moved from a low physical activity level to a moderate level. The physical health score rose from 57 (63-37) to 65 (72-54). The mental health score rose from 57 (63-37) to 65 (72-54). Conclusions: A short-term improvement in physical activity and quality of life was observed in post-treatment cancer patients. However, stronger studies are needed to confirm these results.","PeriodicalId":14008,"journal":{"name":"International Journal of Innovative Research in Medical Science","volume":"68 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141798426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-27DOI: 10.23958/ijirms/vol09-i07/1932
Dasari Ramya, Dr Vandana Raghunath, Dr. Polisetty Siva Krishna, Dr. Firoz Kamal, Dr. Vatsalya Kommalapati, Dr Aparna Latha
Adenomatoid Odontogenic Tumour (AOT) is a rare benign tumour that only occurs in the maxillofacial region, accounting for 3% of all odontogenic tumours. It primarily affects females in their second decade, with a preference for the anterior maxillary region. It is divided into three types: follicular, extrafollicular, and peripheral. Follicular variations involving all four canines account for 60% and 40% of all canine variants, respectively. Dentigerous cyst is an odontogenic cyst that typically develops from impacted mandibular third teeth. The epithelial lining of a Dentigerous cyst may develop into an odontogenic tumour such as ameloblastoma. Adenomatoid odontogenic tumour (AOT) forming as a complication in a dentigerous cyst has been described as a hybrid variety of AOT. We show five such unusual examples including maxillary right premolar, lateral, canine, maxillary left canine, premolar and left deciduous lateral, canine, permanent central, premolars, and first molars in the second, third, fourth, and second decades, respectively. Thus, in this IHC, a Dentigerous cyst (DC) and AOT emerging from DC were compared using a panel of immunohistochemical markers, including cytokeratin (CK) 18 and 19, to explain the differences between the two. We also go over the clinical, radiological, histopathologic, and therapeutic aspects of these instances.
{"title":"AOT Arising from DC: Report of 5 Rare Cases with IHC and Review of Literature","authors":"Dasari Ramya, Dr Vandana Raghunath, Dr. Polisetty Siva Krishna, Dr. Firoz Kamal, Dr. Vatsalya Kommalapati, Dr Aparna Latha","doi":"10.23958/ijirms/vol09-i07/1932","DOIUrl":"https://doi.org/10.23958/ijirms/vol09-i07/1932","url":null,"abstract":"Adenomatoid Odontogenic Tumour (AOT) is a rare benign tumour that only occurs in the maxillofacial region, accounting for 3% of all odontogenic tumours. It primarily affects females in their second decade, with a preference for the anterior maxillary region. It is divided into three types: follicular, extrafollicular, and peripheral. Follicular variations involving all four canines account for 60% and 40% of all canine variants, respectively. Dentigerous cyst is an odontogenic cyst that typically develops from impacted mandibular third teeth. The epithelial lining of a Dentigerous cyst may develop into an odontogenic tumour such as ameloblastoma. Adenomatoid odontogenic tumour (AOT) forming as a complication in a dentigerous cyst has been described as a hybrid variety of AOT. We show five such unusual examples including maxillary right premolar, lateral, canine, maxillary left canine, premolar and left deciduous lateral, canine, permanent central, premolars, and first molars in the second, third, fourth, and second decades, respectively. Thus, in this IHC, a Dentigerous cyst (DC) and AOT emerging from DC were compared using a panel of immunohistochemical markers, including cytokeratin (CK) 18 and 19, to explain the differences between the two. We also go over the clinical, radiological, histopathologic, and therapeutic aspects of these instances.","PeriodicalId":14008,"journal":{"name":"International Journal of Innovative Research in Medical Science","volume":"5 48","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141797657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-25DOI: 10.23958/ijirms/vol09-i07/1934
Wiam AIT DRISS, Rania El Fargani, M. Idalene, N. Tassi
Introduction: The SARS COV 2 pandemic and related lockdown policy have led to an exceptional health crisis, with a potential impact on the care of chronically ill patients, including those living with HIV (PLHIV). Objective: To estimate the incidence of missing patients among PLHIV during the covid 19 pandemic and to identify the contributing factors and their impact on their medical follow-up. Materials and methods: Retrospective descriptive and analytical study of 30 PLHIV who interrupted their follow-up (lost to follow-up) at the ambulatory clinic of the infectious diseases department at the University Hospital Med VI Marrakech from June 2020 to December 2021. Results: The number of patients lost to follow-up was 30. The mean age was 39.25, ranging from 22 to 65 years. A male predominance was noticed, as 65% of the patients were men. Among the patients lost to follow-up: 60% were former patients, while 40% were newly diagnosed. The mean duration of follow-up was 15.35 months, from 6 months to 2 years. HIV stages were Stage A in 50% of cases, Stage B in 15% and Stage C in 35%. The mean CD4 count was 467 cells/mm3. As for viral load, it was only recorded in 60% of patients, with an average of 129605 copies/ml. Regarding treatment, 85% of patients were on triple therapy, while 15% were not yet on treatment. The identified causes for discontinuation were social causes in 40% of cases, psychological causes in 17% of cases, causes linked to the Covid 19 pandemic in 36% of cases, and other causes in 7% of cases. Follow-up was resumed by 54% of patients, while complications were recorded in 35% of cases. Conclusion: Our study demonstrates the deleterious impact of the COVID-19 pandemic on the management of HIV infection and underscores the necessity of developing and implementing new effective strategies to mitigate its negative effects on a vulnerable population, such as people living with HIV (PLHIV).
{"title":"HIV Patients Lost to Follow-Up During the Covid 19 Pandemic","authors":"Wiam AIT DRISS, Rania El Fargani, M. Idalene, N. Tassi","doi":"10.23958/ijirms/vol09-i07/1934","DOIUrl":"https://doi.org/10.23958/ijirms/vol09-i07/1934","url":null,"abstract":"Introduction: The SARS COV 2 pandemic and related lockdown policy have led to an exceptional health crisis, with a potential impact on the care of chronically ill patients, including those living with HIV (PLHIV). Objective: To estimate the incidence of missing patients among PLHIV during the covid 19 pandemic and to identify the contributing factors and their impact on their medical follow-up. Materials and methods: Retrospective descriptive and analytical study of 30 PLHIV who interrupted their follow-up (lost to follow-up) at the ambulatory clinic of the infectious diseases department at the University Hospital Med VI Marrakech from June 2020 to December 2021. Results: The number of patients lost to follow-up was 30. The mean age was 39.25, ranging from 22 to 65 years. A male predominance was noticed, as 65% of the patients were men. Among the patients lost to follow-up: 60% were former patients, while 40% were newly diagnosed. The mean duration of follow-up was 15.35 months, from 6 months to 2 years. HIV stages were Stage A in 50% of cases, Stage B in 15% and Stage C in 35%. The mean CD4 count was 467 cells/mm3. As for viral load, it was only recorded in 60% of patients, with an average of 129605 copies/ml. Regarding treatment, 85% of patients were on triple therapy, while 15% were not yet on treatment. The identified causes for discontinuation were social causes in 40% of cases, psychological causes in 17% of cases, causes linked to the Covid 19 pandemic in 36% of cases, and other causes in 7% of cases. Follow-up was resumed by 54% of patients, while complications were recorded in 35% of cases. Conclusion: Our study demonstrates the deleterious impact of the COVID-19 pandemic on the management of HIV infection and underscores the necessity of developing and implementing new effective strategies to mitigate its negative effects on a vulnerable population, such as people living with HIV (PLHIV).","PeriodicalId":14008,"journal":{"name":"International Journal of Innovative Research in Medical Science","volume":"29 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141802806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-25DOI: 10.23958/ijirms/vol09-i07/1930
Lokireddy Padmaja, Dr. Sudha Ranganathan, Saketh Khammammettu, Dr. Sandeep Nagapuri, Ameena Shaik
Autoimmune hemolytic anemia (AIHA) is a condition where the body's immune system destroys its own red blood cells, leading to symptoms such as fatigue, pallor, jaundice, and shortness of breath. AIHA presents a complex clinical challenge during pregnancy [1]. There is paucity of information on management of complex cases of steroid refractory AIHA. Here, we discuss a unique case of a 24-year-old primigravida who presented with anemia and jaundice at 6 weeks of gestation. Sequential therapies including steroids, IVIG, Rituximab, Cyclophosphamide, and plasma exchange proved refractory. A peri-partum splenectomy performed simultaneously with an early cesarean section at 32 weeks’ gestation resulted in resolution of this patient's AIHA.
{"title":"Resolution of Complex Refractory Autoimmune Hemolytic Anemia in Pregnancy after Five Lines of Therapy-True Multidisciplinary Approach","authors":"Lokireddy Padmaja, Dr. Sudha Ranganathan, Saketh Khammammettu, Dr. Sandeep Nagapuri, Ameena Shaik","doi":"10.23958/ijirms/vol09-i07/1930","DOIUrl":"https://doi.org/10.23958/ijirms/vol09-i07/1930","url":null,"abstract":"Autoimmune hemolytic anemia (AIHA) is a condition where the body's immune system destroys its own red blood cells, leading to symptoms such as fatigue, pallor, jaundice, and shortness of breath. AIHA presents a complex clinical challenge during pregnancy [1]. There is paucity of information on management of complex cases of steroid refractory AIHA. Here, we discuss a unique case of a 24-year-old primigravida who presented with anemia and jaundice at 6 weeks of gestation. Sequential therapies including steroids, IVIG, Rituximab, Cyclophosphamide, and plasma exchange proved refractory. A peri-partum splenectomy performed simultaneously with an early cesarean section at 32 weeks’ gestation resulted in resolution of this patient's AIHA.","PeriodicalId":14008,"journal":{"name":"International Journal of Innovative Research in Medical Science","volume":"20 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141803128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-24DOI: 10.23958/ijirms/vol09-i07/1931
Upinder Singh, Shreyam Acharya, Tushar Sehgal
Background: The microscopic examination of peripheral blood film is labour-intensive, subjective and time-consuming. It also requires trained technical staff. Technological advancements have been made to develop automated morphological analytical systems for the classification of both red blood cells and white blood cells. We aimed to investigate the ability of the automated microscopy system AI100 with the ShonitTM to examine peripheral blood films. Methods: The study was a prospective study done at the All India Institute of Medical Sciences, New Delhi. We compared the automated morphological analysis system AI100 with ShonitTM with the gold standard of manual microscopy to identify morphological abnormalities in the blood. Results: A total of 108 cases were studied. Twenty-one cases were excluded due to suboptimal staining and smearing. The male-to-female ratio was 7:5, and the median age was 31.1 Years. The Pearson correlation (r) between % of WBCs between AI100 and manual microscopy was 0.92,0.81, 0.34, 0.94 and 0.25 for neutrophils, lymphocytes, monocytes, eosinophils and basophils, respectively. The concordance of AI100 and manual microscopy for microcytes, macrocytes, tear drop cells, target cells, acanthocytes, and echinocytes was 77%, 86%, 100%, 100%,95% and 97%, respectively. The concordance of AI100 and manual microscopy for platelet count, clumps, and giant platelets was 89%,100% and 89%. Conclusions: The automated cell analysis system AI100 with ShonitTM is capable of morphological classification of RBC, WBC and platelet in peripheral blood smears.
{"title":"Evaluation of Automated Blood Microscopy System AI100 with ShonitTM in a Tertiary Care Center in Northern India","authors":"Upinder Singh, Shreyam Acharya, Tushar Sehgal","doi":"10.23958/ijirms/vol09-i07/1931","DOIUrl":"https://doi.org/10.23958/ijirms/vol09-i07/1931","url":null,"abstract":"Background: The microscopic examination of peripheral blood film is labour-intensive, subjective and time-consuming. It also requires trained technical staff. Technological advancements have been made to develop automated morphological analytical systems for the classification of both red blood cells and white blood cells. We aimed to investigate the ability of the automated microscopy system AI100 with the ShonitTM to examine peripheral blood films. Methods: The study was a prospective study done at the All India Institute of Medical Sciences, New Delhi. We compared the automated morphological analysis system AI100 with ShonitTM with the gold standard of manual microscopy to identify morphological abnormalities in the blood. Results: A total of 108 cases were studied. Twenty-one cases were excluded due to suboptimal staining and smearing. The male-to-female ratio was 7:5, and the median age was 31.1 Years. The Pearson correlation (r) between % of WBCs between AI100 and manual microscopy was 0.92,0.81, 0.34, 0.94 and 0.25 for neutrophils, lymphocytes, monocytes, eosinophils and basophils, respectively. The concordance of AI100 and manual microscopy for microcytes, macrocytes, tear drop cells, target cells, acanthocytes, and echinocytes was 77%, 86%, 100%, 100%,95% and 97%, respectively. The concordance of AI100 and manual microscopy for platelet count, clumps, and giant platelets was 89%,100% and 89%. Conclusions: The automated cell analysis system AI100 with ShonitTM is capable of morphological classification of RBC, WBC and platelet in peripheral blood smears.","PeriodicalId":14008,"journal":{"name":"International Journal of Innovative Research in Medical Science","volume":"32 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141808148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-17DOI: 10.23958/ijirms/vol09-i07/1927
Kamal Haddouali, Nour El Houda Sguiar Lhamdani, S. Bellakhdar, H. El Otmani, Bouchra El Moutawakil, Mohammed Abdoh Rafai
Symptom onset in Neuromyelitis Optica spectrum disorder (NMOSD) is often acute, while sudden onset is rare and suggests vascular causes. We report the case of a 63-year-old woman who had two sudden attacks, blindness in the left eye and weakness of the lower limbs. The presence of a diencephalic hypersignal around the third ventricle and a bright spotty lesion on the MRI had evoked the NMOSD diagnosis which was confirmed by positive anti-aquaporin 4 antibodies in the serum. The patient was treated with cyclophosphamide with no relapses after 6 months of treatment. Few case reports have been published on this subject, testifying to the rarity of this "pseudo-vascular" mode of revelation of NMOSD, which may be a source of diagnostic error or delay.
{"title":"Pseudovascular Revelation of Seropositive Neuromyelitis Optica Spectrum Disorder: A Case Report","authors":"Kamal Haddouali, Nour El Houda Sguiar Lhamdani, S. Bellakhdar, H. El Otmani, Bouchra El Moutawakil, Mohammed Abdoh Rafai","doi":"10.23958/ijirms/vol09-i07/1927","DOIUrl":"https://doi.org/10.23958/ijirms/vol09-i07/1927","url":null,"abstract":"Symptom onset in Neuromyelitis Optica spectrum disorder (NMOSD) is often acute, while sudden onset is rare and suggests vascular causes. We report the case of a 63-year-old woman who had two sudden attacks, blindness in the left eye and weakness of the lower limbs. The presence of a diencephalic hypersignal around the third ventricle and a bright spotty lesion on the MRI had evoked the NMOSD diagnosis which was confirmed by positive anti-aquaporin 4 antibodies in the serum. The patient was treated with cyclophosphamide with no relapses after 6 months of treatment. Few case reports have been published on this subject, testifying to the rarity of this \"pseudo-vascular\" mode of revelation of NMOSD, which may be a source of diagnostic error or delay.","PeriodicalId":14008,"journal":{"name":"International Journal of Innovative Research in Medical Science","volume":" 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141830462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-16DOI: 10.23958/ijirms/vol09-i07/1926
Kamal Haddouali, Zahra El Bidaoui, Karima Ait Lahcen, H. Khattab, S. Bellakhdar, Nabil Chikhaoui, H. El Otmani, B. Moutawakil, Mohammed Abdoh Rafai
Objective: Intravenous thrombolysis of acute ischemic stroke uses alteplase, which has long been approved for this indication. In the same context, studies on Tenecteplase have demonstrated the efficacy and safety of this molecule, which we use in our structure following clinical and radiological evaluation using non-enhanced computed tomography. Our aim is to share our institutional approach. Materials and Methods: Retrospective, descriptive, cross-sectional study in the neurology department of Casablanca over a 5-year period from 01 January 2018 to 31 December 2022. We included all patients with suspected acute stroke who underwent IVT with Tenecteplase with an Alberta Stroke Program Early CT Score greater than or equal to 7 on non-enhanced cerebral computed tomography. The Modified Rankin Scale was evaluated at 3 months. Results: During these 5 years, 140 patients (49% were females) had received Tenecteplase thrombolytic therapy. The mean age was 67 years, mean National Institutes of Health Stroke Scale was 13/42, mean Alberta Stroke Program Early CT Score was 8/10. 97% of the patients received a dose of 0.25mg/kg of Tenecteplase in a mean time of 210min from the onset of symptoms. The Modified Rankin Scale between 0 and 2 at 3 months was in 46% and 13% of death. Conclusion: We are satisfied with the results of Intravenous thrombolysis with Tenecteplase. However, we are convinced of the limited information provided by a non-enhanced cerebral computed tomography to brain magnetic resonance imaging which remains difficult to access in our context.
{"title":"The Use of Tenecteplase in Combination with Brain Scan Analysis in Thrombolysis of Acute Ischemic Stroke: A Moroccan Experience","authors":"Kamal Haddouali, Zahra El Bidaoui, Karima Ait Lahcen, H. Khattab, S. Bellakhdar, Nabil Chikhaoui, H. El Otmani, B. Moutawakil, Mohammed Abdoh Rafai","doi":"10.23958/ijirms/vol09-i07/1926","DOIUrl":"https://doi.org/10.23958/ijirms/vol09-i07/1926","url":null,"abstract":"Objective: Intravenous thrombolysis of acute ischemic stroke uses alteplase, which has long been approved for this indication. In the same context, studies on Tenecteplase have demonstrated the efficacy and safety of this molecule, which we use in our structure following clinical and radiological evaluation using non-enhanced computed tomography. Our aim is to share our institutional approach. Materials and Methods: Retrospective, descriptive, cross-sectional study in the neurology department of Casablanca over a 5-year period from 01 January 2018 to 31 December 2022. We included all patients with suspected acute stroke who underwent IVT with Tenecteplase with an Alberta Stroke Program Early CT Score greater than or equal to 7 on non-enhanced cerebral computed tomography. The Modified Rankin Scale was evaluated at 3 months. Results: During these 5 years, 140 patients (49% were females) had received Tenecteplase thrombolytic therapy. The mean age was 67 years, mean National Institutes of Health Stroke Scale was 13/42, mean Alberta Stroke Program Early CT Score was 8/10. 97% of the patients received a dose of 0.25mg/kg of Tenecteplase in a mean time of 210min from the onset of symptoms. The Modified Rankin Scale between 0 and 2 at 3 months was in 46% and 13% of death. Conclusion: We are satisfied with the results of Intravenous thrombolysis with Tenecteplase. However, we are convinced of the limited information provided by a non-enhanced cerebral computed tomography to brain magnetic resonance imaging which remains difficult to access in our context.","PeriodicalId":14008,"journal":{"name":"International Journal of Innovative Research in Medical Science","volume":" 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141832112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: This study aims to evaluate the outcome of low-dose aspirin administration in complicated pregnancies with idiopathic alpha-fetoprotein (AFP) elevation. Methods: In this randomized controlled trial, 200 participants with singleton pregnancies presenting with idiopathic elevated alpha-fetoprotein (AFP>2 multiples of the median (MoM)) were recruited. Patients in their 16th to 20th week underwent ultrasonography and Doppler imaging as diagnostic tests. Based on the results of the diagnostic tests, patients were divided into two groups. Normal uterine artery Doppler group (N=100) and Abnormal group(N=100). patients divided into two groups in terms of aspirin intake. Primary complications included preterm delivery, fetal death, intrauterine growth restriction (IUGR), preeclampsia and neonatal hospitalization. Results: From May 2015 through June 2016, 200 women were randomized as follows: 100 to 80 mg ASA tab; 100 to no treatment. Most characteristics were similar across groups. The risk of the IUGR was 2% versus 14% p-value: 0.027, the risk of preterm labor and Neonatal hospitalization were also less, but the risk of IUFD and preeclampsia did not change. Conclusion: Administration of low dose of aspirin can have prophylactic effects against some adverse outcomes in complicated pregnancies presenting with elevated alpha-fetoprotein levels.
{"title":"Effect of Low Dose Aspirin Administration in Idioipathic Alpha-fetoprotein Elevation","authors":"Fatemeh Bahadori, Yasaman Oliapour, Samira Jahangard, Azam Tagavi, Hamid Khalkhali","doi":"10.23958/ijirms/vol09-i07/1925","DOIUrl":"https://doi.org/10.23958/ijirms/vol09-i07/1925","url":null,"abstract":"Objective: This study aims to evaluate the outcome of low-dose aspirin administration in complicated pregnancies with idiopathic alpha-fetoprotein (AFP) elevation. Methods: In this randomized controlled trial, 200 participants with singleton pregnancies presenting with idiopathic elevated alpha-fetoprotein (AFP>2 multiples of the median (MoM)) were recruited. Patients in their 16th to 20th week underwent ultrasonography and Doppler imaging as diagnostic tests. Based on the results of the diagnostic tests, patients were divided into two groups. Normal uterine artery Doppler group (N=100) and Abnormal group(N=100). patients divided into two groups in terms of aspirin intake. Primary complications included preterm delivery, fetal death, intrauterine growth restriction (IUGR), preeclampsia and neonatal hospitalization. Results: From May 2015 through June 2016, 200 women were randomized as follows: 100 to 80 mg ASA tab; 100 to no treatment. Most characteristics were similar across groups. The risk of the IUGR was 2% versus 14% p-value: 0.027, the risk of preterm labor and Neonatal hospitalization were also less, but the risk of IUFD and preeclampsia did not change. Conclusion: Administration of low dose of aspirin can have prophylactic effects against some adverse outcomes in complicated pregnancies presenting with elevated alpha-fetoprotein levels.","PeriodicalId":14008,"journal":{"name":"International Journal of Innovative Research in Medical Science","volume":" 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141833087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-15DOI: 10.23958/ijirms/vol09-i07/1922
Rhitam Ghosal, Swagata Gayen, S. Mahmud, S. Das, Mousumi Pal
Dental caries is an irreversible microbial disease of the calcified tissues of the teeth, characterized by demineralization of the inorganic portion and destruction of the organic substance of the tooth, which often leads to cavitation. Untreated dental caries in deciduous teeth was the tenth most widespread and the fourth most expensive chronic illness to treat condition among children worldwide, with prevalence peaking at the age of six. Individuals with active caries have an elevated serum antibody level for mutans streptococci. Findings also suggest that an increased antigenic load (bacteria from lesions) will give rise to elevated salivary antibody. Subjects with selective IgA deficiency without salivary antibody show markedly elevated levels of dental caries when compared to normal controls. IgA deficient subjects with IgM compensatory antibodies have significantly less caries than simply IgA deficient subjects. The immune system in secretions have been used to interfere with caries by stimulating salivary antibodies to appropriate antigens. The gingival crevicular fluid contributes IgG, which can also interfere with caries.This review article emphasizes the comprehensive and contemporary idea about immunological aspect of dental caries along with overview on dental caries and immunity and recent advancements in the field of caries vaccine.
龋齿是牙齿钙化组织的一种不可逆转的微生物疾病，其特点是牙齿的无机部分脱矿和有机物质破坏，通常会导致龋齿。在全世界儿童中，未经治疗的乳牙龋齿是第十大最普遍的慢性疾病，也是第四大最昂贵的慢性疾病，发病率在六岁时达到高峰。活动性龋齿患者血清中的变异链球菌抗体水平升高。研究结果还表明，抗原负荷（来自病变部位的细菌）增加会导致唾液抗体升高。与正常对照组相比，无唾液抗体的选择性 IgA 缺乏症患者的龋齿水平明显升高。与单纯的 IgA 缺乏症患者相比，IgM 代偿抗体缺乏症患者的龋齿明显较少。分泌物中的免疫系统已被用于通过刺激唾液中的适当抗原抗体来干扰龋病。这篇综述文章强调了有关龋齿免疫学方面的全面和现代观念，以及龋齿和免疫的概述和龋病疫苗领域的最新进展。
{"title":"A Brief Review on Immunology of Dental Caries and Caries Vaccine","authors":"Rhitam Ghosal, Swagata Gayen, S. Mahmud, S. Das, Mousumi Pal","doi":"10.23958/ijirms/vol09-i07/1922","DOIUrl":"https://doi.org/10.23958/ijirms/vol09-i07/1922","url":null,"abstract":"Dental caries is an irreversible microbial disease of the calcified tissues of the teeth, characterized by demineralization of the inorganic portion and destruction of the organic substance of the tooth, which often leads to cavitation. Untreated dental caries in deciduous teeth was the tenth most widespread and the fourth most expensive chronic illness to treat condition among children worldwide, with prevalence peaking at the age of six. Individuals with active caries have an elevated serum antibody level for mutans streptococci. Findings also suggest that an increased antigenic load (bacteria from lesions) will give rise to elevated salivary antibody. Subjects with selective IgA deficiency without salivary antibody show markedly elevated levels of dental caries when compared to normal controls. IgA deficient subjects with IgM compensatory antibodies have significantly less caries than simply IgA deficient subjects. The immune system in secretions have been used to interfere with caries by stimulating salivary antibodies to appropriate antigens. The gingival crevicular fluid contributes IgG, which can also interfere with caries.\u0000This review article emphasizes the comprehensive and contemporary idea about immunological aspect of dental caries along with overview on dental caries and immunity and recent advancements in the field of caries vaccine.","PeriodicalId":14008,"journal":{"name":"International Journal of Innovative Research in Medical Science","volume":" 62","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141833426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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