Pub Date : 2022-09-05DOI: 10.11603/ijmmr.2413-6077.2022.1.13094
I. Klishch, A. Dovbush, H. O. Havryliuk-Skiba, O. P. Andriyishyn
Background. Today, among the increasing number of various diseases, stress is a trigger in the development of diseases and mortality among the population. Objective. To establish submicroscopic changes in the hemocapillaries of the islets of Langerhans of the pancreas and adrenal glands in the presence of immobilization stress with underlying hypothyroidism. Methods. The experiment was carried out on 20 mature white male rats. Hypothyroidism was modeled by daily per os injection with a probe of the pharmacopoeial mercazole thyreostatics at a dose of 25 mg/kg for 21 days. Acute immobilization stress was modeled by tying the experimental rats in a supine position in 4 limbs without restricting head mobility for 3 hours. The study was conducted 2 hours later (anxiety stage) after the end of the stress impact. The material was collected for electron microscopy and tissue processing was performed according to generally accepted methods. Results. Electron microscopic examination of the blood capillaries of the islets of Langerhans in the pancreas and the hemocapillaries of the adrenal cortex after the action of the stress factor in cases of hypothyroidism showed slightly enlarged lumens and moderate perivascular edema. The basement membrane was moderately thickened but clearly contoured. Endotheliocyte nuclei were mostly hypertrophied, euchromatin was uniformly located in the nucleoplasm, and nucleoli were defined. The karyolemma was clearly contoured, the number of nuclear pores was small, and the perinuclear lumen was locally widened. Endoplasmic reticulum with moderately expanded and short tubules, moderately thickened cisterns of the Golgi complex were observed in the cytoplasm of endotheliocytes. There were two types of mitochondria: hypertrophied with an electron-light matrix, single cristae, and with clear visible cristae and a moderately electron-dense matrix. In addition to the capillaries mentioned above, there were also single narrowed microvessels that had perivascular edema and vaguely contoured fenestrae. Conclusions. When modeling a stressor in cases of hypothyroidism, structural changes of all components of the walls of blood capillaries of the pancreas and adrenal glands take place.
{"title":"SUBMICROSCOPIC CHANGES IN HEMOCAPILLARIES OF ADRENAL GLAND AND PANCREATIC ISLETS OF LANGERHANS IN CASES OF IMMOBILIZATION STRESS WITH UNDERLYING HYPOTHYROIDISM","authors":"I. Klishch, A. Dovbush, H. O. Havryliuk-Skiba, O. P. Andriyishyn","doi":"10.11603/ijmmr.2413-6077.2022.1.13094","DOIUrl":"https://doi.org/10.11603/ijmmr.2413-6077.2022.1.13094","url":null,"abstract":"Background. Today, among the increasing number of various diseases, stress is a trigger in the development of diseases and mortality among the population. \u0000Objective. To establish submicroscopic changes in the hemocapillaries of the islets of Langerhans of the pancreas and adrenal glands in the presence of immobilization stress with underlying hypothyroidism.\u0000Methods. The experiment was carried out on 20 mature white male rats. Hypothyroidism was modeled by daily per os injection with a probe of the pharmacopoeial mercazole thyreostatics at a dose of 25 mg/kg for 21 days. Acute immobilization stress was modeled by tying the experimental rats in a supine position in 4 limbs without restricting head mobility for 3 hours. The study was conducted 2 hours later (anxiety stage) after the end of the stress impact. The material was collected for electron microscopy and tissue processing was performed according to generally accepted methods.\u0000Results. Electron microscopic examination of the blood capillaries of the islets of Langerhans in the pancreas and the hemocapillaries of the adrenal cortex after the action of the stress factor in cases of hypothyroidism showed slightly enlarged lumens and moderate perivascular edema. The basement membrane was moderately thickened but clearly contoured. Endotheliocyte nuclei were mostly hypertrophied, euchromatin was uniformly located in the nucleoplasm, and nucleoli were defined. The karyolemma was clearly contoured, the number of nuclear pores was small, and the perinuclear lumen was locally widened. Endoplasmic reticulum with moderately expanded and short tubules, moderately thickened cisterns of the Golgi complex were observed in the cytoplasm of endotheliocytes. There were two types of mitochondria: hypertrophied with an electron-light matrix, single cristae, and with clear visible cristae and a moderately electron-dense matrix. In addition to the capillaries mentioned above, there were also single narrowed microvessels that had perivascular edema and vaguely contoured fenestrae.\u0000Conclusions. When modeling a stressor in cases of hypothyroidism, structural changes of all components of the walls of blood capillaries of the pancreas and adrenal glands take place.","PeriodicalId":14059,"journal":{"name":"International Journal of Medicine and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47890791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-05DOI: 10.11603/ijmmr.2413-6077.2022.1.13156
T. Lunova, I. Klishch
Background. Gender differences in the baseline characteristics of patients with the acute coronary syndrome (ACS) have been widely acknowledged. Women are known to be generally older with a higher prevalence of comorbidities. Objectives. Gender differences in the baseline characteristics of patients with the acute coronary syndrome (ACS) have been widely acknowledged. Women are known to be generally older with a higher prevalence of comorbidities. At the same time, it is now yet clear which comorbid conditions have the most significant impact on the long-term outcomes of patients with ACS and if there are any gender differences in this respect. Methods. We performed a retrospective cohort study of 167 patients (109 men and 58 women) admitted to the acute coronary unit of Ternopil Municipal Hospital with ACS in 2016-2017. All relevant clinical information has been recorded in the pre-designed data charts. The incidence of repeated major adverse cardiovascular events (MACEs) has been assessed over 36 months after the hospital discharge via an e-Health electronic system. Results. In this cohort, female patients with ACS had a higher prevalence of comorbid conditions: 15.5% of women vs. 11% of men with ACS had ≥5 comorbidities, 65.5% of women and 60% of men had 2-4 comorbid conditions, and 19% of women vs. 29% ≤1 concomitant disease. The comorbidity structure also differed between genders. Women more often had concomitant cerebrovascular diseases (17.2% vs. 7.3%, p=0.05), dementia (15.5% vs. 5.5 %, p=0.03), connective tissue disorders (17.25 vs. 6.42%, p=0.03) and thyroid disease (12.1% vs. 2.8%, p=0.02). Men more often suffered from peptic ulcer (13.7% vs. 3.4%, p=0.05). The incidence of MACEs during the follow-up period rose sharply with age and was higher in females (55% vs. 33%, p=0.003). In the multivariable model, PAD (OR 9.5, 95% CI: 1.7-52.3, p=0.01) and thyroid disease (OR 7.2, 95% CI: 1.19-43.2, p=0.03) demonstrated the most significant impact on the long-term event-free survival of females in the cohort. In turn, a solid metastatic tumor was the most significant predictor of poor prognosis in men (OR 6.3, 95% CI: 2.13-18.9, p=0.001). Conclusions. We observed significant gender differences in the prevalence of comorbid conditions and their influence on the three-year event-free survival of patients with ACS. The predictive value of comorbidities should be further investigated, preferably, with the involvement of larger cohorts.
{"title":"GENDER DIFFERENCES IN THE INFLUENCE OF COMORBID CONDITIONS ON THE LONG-TERM OUTCOMES OF PATIENTS WITH ACUTE CORONARY SYNDROME","authors":"T. Lunova, I. Klishch","doi":"10.11603/ijmmr.2413-6077.2022.1.13156","DOIUrl":"https://doi.org/10.11603/ijmmr.2413-6077.2022.1.13156","url":null,"abstract":"Background. Gender differences in the baseline characteristics of patients with the acute coronary syndrome (ACS) have been widely acknowledged. Women are known to be generally older with a higher prevalence of comorbidities. \u0000Objectives. Gender differences in the baseline characteristics of patients with the acute coronary syndrome (ACS) have been widely acknowledged. Women are known to be generally older with a higher prevalence of comorbidities. At the same time, it is now yet clear which comorbid conditions have the most significant impact on the long-term outcomes of patients with ACS and if there are any gender differences in this respect. \u0000Methods. We performed a retrospective cohort study of 167 patients (109 men and 58 women) admitted to the acute coronary unit of Ternopil Municipal Hospital with ACS in 2016-2017. All relevant clinical information has been recorded in the pre-designed data charts. The incidence of repeated major adverse cardiovascular events (MACEs) has been assessed over 36 months after the hospital discharge via an e-Health electronic system. \u0000Results. In this cohort, female patients with ACS had a higher prevalence of comorbid conditions: 15.5% of women vs. 11% of men with ACS had ≥5 comorbidities, 65.5% of women and 60% of men had 2-4 comorbid conditions, and 19% of women vs. 29% ≤1 concomitant disease. The comorbidity structure also differed between genders. Women more often had concomitant cerebrovascular diseases (17.2% vs. 7.3%, p=0.05), dementia (15.5% vs. 5.5 %, p=0.03), connective tissue disorders (17.25 vs. 6.42%, p=0.03) and thyroid disease (12.1% vs. 2.8%, p=0.02). Men more often suffered from peptic ulcer (13.7% vs. 3.4%, p=0.05). The incidence of MACEs during the follow-up period rose sharply with age and was higher in females (55% vs. 33%, p=0.003). In the multivariable model, PAD (OR 9.5, 95% CI: 1.7-52.3, p=0.01) and thyroid disease (OR 7.2, 95% CI: 1.19-43.2, p=0.03) demonstrated the most significant impact on the long-term event-free survival of females in the cohort. In turn, a solid metastatic tumor was the most significant predictor of poor prognosis in men (OR 6.3, 95% CI: 2.13-18.9, p=0.001). \u0000Conclusions. We observed significant gender differences in the prevalence of comorbid conditions and their influence on the three-year event-free survival of patients with ACS. The predictive value of comorbidities should be further investigated, preferably, with the involvement of larger cohorts. \u0000 \u0000 \u0000","PeriodicalId":14059,"journal":{"name":"International Journal of Medicine and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43038557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-05DOI: 10.11603/ijmmr.2413-6077.2022.1.12910
L. Levytska, V. Yurkiv, M. Korda
Background. Myocardial infarction (MI) is one of the leading causes of death in working age population; the risk of cardiovascular complications for survivors of acute MI complicated by comorbid pathology (CP) is very high. Objective. The study is aimed to search for reliable prognostic markers for risk of reducing the functional reserves of the cardiovascular system in myocardial infarction with comorbid pathology. Methods. The prospective study involved 371 patients with MI, who received non-invasive therapy and were observed for a 90-day period after admission to the hospital. All patients were examined and treated according to current protocols. Results. It was found that 6-minute walk test (6MWT) is a specific and highly sensitive prognostic marker of functional reserves for patients with MI with CP (specificity – 100%, sensitivity – 63%, prognostic value of a positive result – 100%) with the Charlson comorbidity index (CCI) ≥2. The correlation of 6MWT performed on the 10th, 30th and 90th day of rehabilitation was revealed with the age of patients, SpO2, respiratory rate, systolic blood pressure, heart rate, left ventricular ejection fraction, levels of troponin T, creatinine, the number of lymphocytes in the peripheral blood, CCI (p<0.05). Conclusions. During the 90-day rehabilitation period of a patient with MI complicated by CP, the markers of reduced exercise tolerance to be monitored are: blood pressure levels, respiratory rate, troponin T, creatinine, cholesterol, low-density lipoprotein, SpO2, the number of lymphocytes in the peripheral blood. To improve control over the process of rehabilitation in patients with MI complicated by CP the 6MWT and CCI should be used.
{"title":"PREDICTORS OF LOW FUNCTIONAL RESERVES IN REHABILITATION OF PATIENTS WITH MYOCARDIAL INFARCTION COMPLICATED BY COMORBID PATHOLOGY","authors":"L. Levytska, V. Yurkiv, M. Korda","doi":"10.11603/ijmmr.2413-6077.2022.1.12910","DOIUrl":"https://doi.org/10.11603/ijmmr.2413-6077.2022.1.12910","url":null,"abstract":"Background. Myocardial infarction (MI) is one of the leading causes of death in working age population; the risk of cardiovascular complications for survivors of acute MI complicated by comorbid pathology (CP) is very high.\u0000Objective. The study is aimed to search for reliable prognostic markers for risk of reducing the functional reserves of the cardiovascular system in myocardial infarction with comorbid pathology.\u0000Methods. The prospective study involved 371 patients with MI, who received non-invasive therapy and were observed for a 90-day period after admission to the hospital. All patients were examined and treated according to current protocols.\u0000Results. It was found that 6-minute walk test (6MWT) is a specific and highly sensitive prognostic marker of functional reserves for patients with MI with CP (specificity – 100%, sensitivity – 63%, prognostic value of a positive result – 100%) with the Charlson comorbidity index (CCI) ≥2. The correlation of 6MWT performed on the 10th, 30th and 90th day of rehabilitation was revealed with the age of patients, SpO2, respiratory rate, systolic blood pressure, heart rate, left ventricular ejection fraction, levels of troponin T, creatinine, the number of lymphocytes in the peripheral blood, CCI (p<0.05).\u0000Conclusions. During the 90-day rehabilitation period of a patient with MI complicated by CP, the markers of reduced exercise tolerance to be monitored are: blood pressure levels, respiratory rate, troponin T, creatinine, cholesterol, low-density lipoprotein, SpO2, the number of lymphocytes in the peripheral blood. To improve control over the process of rehabilitation in patients with MI complicated by CP the 6MWT and CCI should be used.","PeriodicalId":14059,"journal":{"name":"International Journal of Medicine and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45262763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-05DOI: 10.11603/ijmmr.2413-6077.2022.1.12674
V. Nair, P. Sharma, N. Rajendran, S. Raja, P. Rao, R. Mehta
Background. Gastrointestinal stromal tumours (GIST) are non-epithelial mesenchymal solid neoplasm with varied presentation. The study reports the case of a retroperitoneal GIST in a 21‑year‑old male presented with an abdominal lump for six months. The lesion was initially thought to be a retroperitoneal sarcoma. Exploratory laparotomy revealed an abdominopelvic mass covering the entire right side of abdomen and pelvis. The tumour was adherent to the terminal ileum and ascending colon. There were dense adhesions between the retroperitoneum with involvement of the middle third of the right ureter. The tumour was resected with right hemicolectomy with ileotransverse anastomosis. Post-operative histopathology revealed it as high-grade spindle cell type GIST. The patient is presently on post-operative chemotherapy with Imatinib mesylate. Objective. Atypical presentations of GIST are seldom discussed but frequently encountered in clinical practice. This article depicts different challenges the surgeon has to face while diagnosing such atypical entity. Methods. Case report of atypical GIST presenting as retroperitoneal lump. Results. The patient underwent surgical resection and is presently on post-operative chemotherapy with good overall outcome for a one year follow up. Conclusions. GISTs presenting as retroperitoneal lumps are very rare, they should be considered in their differential diagnosis of an atypical retroperitoneal mass.
{"title":"CASE REPORT ON RARE OUTCOME OF A RETROPERITONEAL MASS: MANAGEMENT CHALLENGES AND LESSONS LEARNT","authors":"V. Nair, P. Sharma, N. Rajendran, S. Raja, P. Rao, R. Mehta","doi":"10.11603/ijmmr.2413-6077.2022.1.12674","DOIUrl":"https://doi.org/10.11603/ijmmr.2413-6077.2022.1.12674","url":null,"abstract":"Background. Gastrointestinal stromal tumours (GIST) are non-epithelial mesenchymal solid neoplasm with varied presentation. The study reports the case of a retroperitoneal GIST in a 21‑year‑old male presented with an abdominal lump for six months. The lesion was initially thought to be a retroperitoneal sarcoma. Exploratory laparotomy revealed an abdominopelvic mass covering the entire right side of abdomen and pelvis. The tumour was adherent to the terminal ileum and ascending colon. There were dense adhesions between the retroperitoneum with involvement of the middle third of the right ureter. The tumour was resected with right hemicolectomy with ileotransverse anastomosis. Post-operative histopathology revealed it as high-grade spindle cell type GIST. The patient is presently on post-operative chemotherapy with Imatinib mesylate.\u0000Objective. Atypical presentations of GIST are seldom discussed but frequently encountered in clinical practice. This article depicts different challenges the surgeon has to face while diagnosing such atypical entity.\u0000Methods. Case report of atypical GIST presenting as retroperitoneal lump.\u0000Results. The patient underwent surgical resection and is presently on post-operative chemotherapy with good overall outcome for a one year follow up.\u0000Conclusions. GISTs presenting as retroperitoneal lumps are very rare, they should be considered in their differential diagnosis of an atypical retroperitoneal mass.","PeriodicalId":14059,"journal":{"name":"International Journal of Medicine and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42496131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-18DOI: 10.11603/ijmmr.2413-6077.2021.2.12556
T. V. Romaniuk, V. Moroz, S. Maslii, Z. Vivchar
Background. Patients undergoing cardiac surgery are under a high risk of post-operative reductions in respiratory muscle strength and pulmonary function as well as lowered functional capacity. In-hospital physical inactivity and inappropriate rehabilitation increases the chances for development of these complications and affects patients’ future independence in daily routine. Cardiac rehabilitation is crucial in preventing complications and assisting the early function recovery. However, despite the evidences for its benefits and strong guideline recommendations, the uptake of cardiac rehabilitation remains poor. Objective. this study is aimed at promotion of cardiac rehabilitation and sharing successful experience of using it. Methods. Post-surgical treatment and rehabilitation of 387 patients with cardiovascular pathology in the Department of Vascular and Cardiac Surgery of Municipal Non-Commercial Enterprise “Ternopil Regional Clinical Hospital” of Ternopil Regional Council has been analysed. Results. The experience of successful post-surgical treatment and rehabilitation allowed establishing the basic approaches to perioperative management of patients with cardiovascular surgical pathology. Key principles include minimized ICU stay and artificial ventilation time, early verticalization and beginning of physical activities, early removed drainage tubes, tracheobronchial tree drainage, nutritional balance, lymphatic drainage massage, application of elastic jersey on the lower extremities, early transferring to the surgery ward and returning to the regular daily activities, circumstantial health education, complex work of a multidisciplinary team. Conclusions. This set of rehabilitation measures helps prevent complications after cardiac surgery as well as provide a faster patient’s daily routine.
{"title":"REHABILITATION OF PATIENTS AFTER CARDIAC SURGERY","authors":"T. V. Romaniuk, V. Moroz, S. Maslii, Z. Vivchar","doi":"10.11603/ijmmr.2413-6077.2021.2.12556","DOIUrl":"https://doi.org/10.11603/ijmmr.2413-6077.2021.2.12556","url":null,"abstract":"Background. Patients undergoing cardiac surgery are under a high risk of post-operative reductions in respiratory muscle strength and pulmonary function as well as lowered functional capacity. In-hospital physical inactivity and inappropriate rehabilitation increases the chances for development of these complications and affects patients’ future independence in daily routine. Cardiac rehabilitation is crucial in preventing complications and assisting the early function recovery. However, despite the evidences for its benefits and strong guideline recommendations, the uptake of cardiac rehabilitation remains poor.\u0000Objective. this study is aimed at promotion of cardiac rehabilitation and sharing successful experience of using it.\u0000Methods. Post-surgical treatment and rehabilitation of 387 patients with cardiovascular pathology in the Department of Vascular and Cardiac Surgery of Municipal Non-Commercial Enterprise “Ternopil Regional Clinical Hospital” of Ternopil Regional Council has been analysed.\u0000Results. The experience of successful post-surgical treatment and rehabilitation allowed establishing the basic approaches to perioperative management of patients with cardiovascular surgical pathology. Key principles include minimized ICU stay and artificial ventilation time, early verticalization and beginning of physical activities, early removed drainage tubes, tracheobronchial tree drainage, nutritional balance, lymphatic drainage massage, application of elastic jersey on the lower extremities, early transferring to the surgery ward and returning to the regular daily activities, circumstantial health education, complex work of a multidisciplinary team.\u0000Conclusions. This set of rehabilitation measures helps prevent complications after cardiac surgery as well as provide a faster patient’s daily routine.","PeriodicalId":14059,"journal":{"name":"International Journal of Medicine and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42395023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-18DOI: 10.11603/ijmmr.2413-6077.2021.2.12657
S. Nykytyuk, S. Klymnyuk, I. Klishch, S. Levenets
Background. Lyme disease (LD) is a multisystem disorder caused by Borrelia burgdorferi and other similar tick-borne Borrelia. Objective. The aim of the research was to compare the results of the serological examination of children with different forms of Lyme disease. Methods. We observed the group of children (n=178) aged 1 to 14 years who were bitten by ticks. The control group consisted of 30 healthy children. Ticks were identified using a stereomicroscopic SEO system which included a stereomicroscope, a colour digital camera and a photoadapter. B. burgdorferi sensu lato (sl) (B. burgdorferi sensu stricto, B. afzeliі and B. garinii), B. miyamotoi, A. phagocytophilum DNA in blood were determined by real-time PCR. Baseline investigations related to clinical and immunological studies, including ELISA and Immunoblot, were performed. Results. The survey covered 178 child parents bitten by ticks. Borrelia burgdorferi sensu lato (B. afzelii, B. burgdorferi sensu stricto and B. garinii), B. miyamotoi and A. phagocytophilum were identified. Serological results in children with different forms of Lyme disease were compared. Conclusions. It is established that B. burgdorferi sensu lato; B. miyamotoi; and A. phagocytophilum are pathogens that cause erythema migrans in children. The presence of specific IgG (only positive results) to B. burgdorferi s.l. by immunoblot was confirmed in 83.8% of individuals who had positive and intermediate results in the ELISA test.
背景莱姆病（LD）是由伯氏疏螺旋体和其他类似的蜱传性疏螺旋体引起的一种多系统疾病。目的：比较不同类型莱姆病患儿的血清学检查结果。方法。我们观察了一组1至14岁被蜱虫叮咬的儿童（n=178）。对照组由30名健康儿童组成。蜱虫是使用立体显微镜SEO系统识别的，该系统包括立体显微镜、彩色数码相机和光适配器。用实时聚合酶链反应（PCR）测定了血液中的广义伯氏芽孢杆菌（B.burgdorferi sensu lato，sl）、阿氏芽孢杆菌和加里尼芽孢杆菌（B.garinii）、米亚莫泰芽孢杆菌、嗜吞噬细胞芽孢杆菌的DNA。进行了与临床和免疫学研究相关的基线调查，包括ELISA和免疫印迹。后果这项调查覆盖了178名被蜱虫叮咬的儿童家长。鉴定出了广义伯氏疏螺旋体（B.afzelii、B.burgdorferi senso stricto和B.garinii）、米亚莫托芽孢杆菌和嗜吞噬细胞芽孢杆菌。对患有不同形式莱姆病的儿童的血清学结果进行了比较。结论。确定伯氏双歧杆菌属；B.miyamotoi；嗜吞噬细胞A.是导致儿童迁移性红斑的病原体。通过免疫印迹法，83.8%的ELISA检测结果为阳性和中间结果的个体中确认存在针对伯氏双歧杆菌的特异性IgG（仅阳性结果）。
{"title":"EVALUATION OF IMMUNOBLOT RESULTS FOR DETERMINATION OF ANTIBODIES TO LYME DISEASE PATHOGENS IN CHILDREN OF TERNOPIL REGION","authors":"S. Nykytyuk, S. Klymnyuk, I. Klishch, S. Levenets","doi":"10.11603/ijmmr.2413-6077.2021.2.12657","DOIUrl":"https://doi.org/10.11603/ijmmr.2413-6077.2021.2.12657","url":null,"abstract":"Background. Lyme disease (LD) is a multisystem disorder caused by Borrelia burgdorferi and other similar tick-borne Borrelia.\u0000Objective. The aim of the research was to compare the results of the serological examination of children with different forms of Lyme disease. \u0000Methods. We observed the group of children (n=178) aged 1 to 14 years who were bitten by ticks. The control group consisted of 30 healthy children. Ticks were identified using a stereomicroscopic SEO system which included a stereomicroscope, a colour digital camera and a photoadapter. B. burgdorferi sensu lato (sl) (B. burgdorferi sensu stricto, B. afzeliі and B. garinii), B. miyamotoi, A. phagocytophilum DNA in blood were determined by real-time PCR. Baseline investigations related to clinical and immunological studies, including ELISA and Immunoblot, were performed.\u0000Results. The survey covered 178 child parents bitten by ticks. Borrelia burgdorferi sensu lato (B. afzelii, B. burgdorferi sensu stricto and B. garinii), B. miyamotoi and A. phagocytophilum were identified. Serological results in children with different forms of Lyme disease were compared.\u0000Conclusions. It is established that B. burgdorferi sensu lato; B. miyamotoi; and A. phagocytophilum are pathogens that cause erythema migrans in children. The presence of specific IgG (only positive results) to B. burgdorferi s.l. by immunoblot was confirmed in 83.8% of individuals who had positive and intermediate results in the ELISA test.","PeriodicalId":14059,"journal":{"name":"International Journal of Medicine and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43895377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-18DOI: 10.11603/ijmmr.2413-6077.2021.2.12486
N. S. Hutor
Background. Tooth extraction is the most common surgical intervention in the outpatient practice of a dental surgeon. In most cases, bone wound healing is uncomplicated. However, in some patients the course of healing is complicated by acute inflammatory process of dry socket (alveolar osteitis), the frequency of which increases with increasing trauma of surgery. In dentally healthy patients with typical tooth extraction, dry socket occurs in 2.55%, with difficult – in 9.84%, with atypical extraction of the lower wisdom tooth – in 31.03% of cases. In the presence of diabetes, the incidence of dry socket with typical removal is much higher and according to various authors it is 9.7-13.5%. Objective. The aim of the research was to study the publications and their analysis on the current diagnosis, prevention and treatment of patients with dry socket. Methods. Scientific sources were the articles in world periodicals on dental surgery and therapy, microbiology as well as some electronic resources and patents. Results. At present, many techniques, methods, schemes, compositions for treatment of various forms of dry socket are established. Most often, antibacterial drugs or their combinations with other drugs are used. However, antibacterial drugs do not always have a pronounced anti-inflammatory effect due to the high resistance of the oral microflora. In these cases, contemporary drugs in the form of a composition with long-term antiseptic, anti-inflammatory and analgesic action are rational. Conclusions. The action of a Flupetsal composition, which contains antimicrobial and immunomodulatory drug flurenizide, was clinically proven for treatment of patients with dry socket; the properties of the available ingredients provide a high disinfectant effect, prevent development of inflammation in the tissues and its transition to purulence. A contemporary effective method of treating patients with dry socket is carried out according to the developed method.
{"title":"CURRENT DIAGNOSIS, PREVENTION AND TREATMENT OF DRY SOCKET","authors":"N. S. Hutor","doi":"10.11603/ijmmr.2413-6077.2021.2.12486","DOIUrl":"https://doi.org/10.11603/ijmmr.2413-6077.2021.2.12486","url":null,"abstract":"Background. Tooth extraction is the most common surgical intervention in the outpatient practice of a dental surgeon. In most cases, bone wound healing is uncomplicated. However, in some patients the course of healing is complicated by acute inflammatory process of dry socket (alveolar osteitis), the frequency of which increases with increasing trauma of surgery. In dentally healthy patients with typical tooth extraction, dry socket occurs in 2.55%, with difficult – in 9.84%, with atypical extraction of the lower wisdom tooth – in 31.03% of cases. In the presence of diabetes, the incidence of dry socket with typical removal is much higher and according to various authors it is 9.7-13.5%. \u0000Objective. The aim of the research was to study the publications and their analysis on the current diagnosis, prevention and treatment of patients with dry socket. \u0000Methods. Scientific sources were the articles in world periodicals on dental surgery and therapy, microbiology as well as some electronic resources and patents. \u0000Results. At present, many techniques, methods, schemes, compositions for treatment of various forms of dry socket are established. Most often, antibacterial drugs or their combinations with other drugs are used. However, antibacterial drugs do not always have a pronounced anti-inflammatory effect due to the high resistance of the oral microflora. In these cases, contemporary drugs in the form of a composition with long-term antiseptic, anti-inflammatory and analgesic action are rational.\u0000Conclusions. The action of a Flupetsal composition, which contains antimicrobial and immunomodulatory drug flurenizide, was clinically proven for treatment of patients with dry socket; the properties of the available ingredients provide a high disinfectant effect, prevent development of inflammation in the tissues and its transition to purulence. A contemporary effective method of treating patients with dry socket is carried out according to the developed method.","PeriodicalId":14059,"journal":{"name":"International Journal of Medicine and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47722331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-18DOI: 10.11603/ijmmr.2413-6077.2021.2.12516
D. Koval, H. R. Malyarchuk, O. O. Levenets
Background. Nowadays, much attention is paid to enterosorption methods that allow cleansing the internal organs and removing extraneous substances out of the body of a sick person. Objective. The aim of the research was to study the effect of microcrystalline cellulose on the microflora of the large intestine. Methods. The study was performed on 50 white laboratory Wistar rats weighing 180-270 g, which were divided into control and experimental groups. The experimental group was daily administered with microcrystalline cellulose at a dose of 500 mg/kg. The study followed ethical standards and recommendations for the humanization of work with laboratory animals according to the “European Convention for the protection of vertebrate animals used for experimental and other purposes” (Strasbourg, 1986, 2010), as well as the requirements of the Commission on Bioethics of I. Horbachevsky Ternopil National Medical University (Minutes No. 66, dated November 01, 2021). The first group involved the intact rats on standard diet, the second – the rats, which received normal feeding of microcrystalline cellulose. Results. In the feces of the experimental white rats treated with microcrystalline cellulose, the level of Escherichia coli in the large intestine decreased by 22 and 25%. The number of these microorganisms increased by 20% in 7 days and by 14% in 14 days. The content of epidermal staphylococci in the stool decreased by 10% on the 7th day of administration. Microcrystalline cellulose increased the number of Staphylococcus aureus by 12%, but decreased the number of enterococci in the feces by 28%. In 7-14 days of the experiment, the content of these bacteria did not change significantly in the colon. In relation to anaerobic microorganisms – bacteroides and clostridia, this supplement caused a slight increase in the number of bacteroides – by 8.64% and the number of clostridia – by 11.54% on the 14th day. The content of fungi of the Candida genus on the 7th and 14th day increased by 8.3%. Conclusions. In the 2nd period of the study, the microbiome of intestinal contents worsened: the process of dysbacteriosis increased, which was manifested by a significant increase in the number of Proteus spp., Staphylococcus aureus, anaerobes (bacteroides, clostridia) and Candida spp., as well as decreased Escherichia coli and Enterococci.
{"title":"THE EFFECT OF MICROCRYSTALLINE CELLULOSE ON THE MICROFLORA OF THE COLON","authors":"D. Koval, H. R. Malyarchuk, O. O. Levenets","doi":"10.11603/ijmmr.2413-6077.2021.2.12516","DOIUrl":"https://doi.org/10.11603/ijmmr.2413-6077.2021.2.12516","url":null,"abstract":"Background. Nowadays, much attention is paid to enterosorption methods that allow cleansing the internal organs and removing extraneous substances out of the body of a sick person.\u0000Objective. The aim of the research was to study the effect of microcrystalline cellulose on the microflora of the large intestine.\u0000Methods. The study was performed on 50 white laboratory Wistar rats weighing 180-270 g, which were divided into control and experimental groups. The experimental group was daily administered with microcrystalline cellulose at a dose of 500 mg/kg. The study followed ethical standards and recommendations for the humanization of work with laboratory animals according to the “European Convention for the protection of vertebrate animals used for experimental and other purposes” (Strasbourg, 1986, 2010), as well as the requirements of the Commission on Bioethics of I. Horbachevsky Ternopil National Medical University (Minutes No. 66, dated November 01, 2021). The first group involved the intact rats on standard diet, the second – the rats, which received normal feeding of microcrystalline cellulose.\u0000Results. In the feces of the experimental white rats treated with microcrystalline cellulose, the level of Escherichia coli in the large intestine decreased by 22 and 25%. The number of these microorganisms increased by 20% in 7 days and by 14% in 14 days. The content of epidermal staphylococci in the stool decreased by 10% on the 7th day of administration. Microcrystalline cellulose increased the number of Staphylococcus aureus by 12%, but decreased the number of enterococci in the feces by 28%. In 7-14 days of the experiment, the content of these bacteria did not change significantly in the colon. In relation to anaerobic microorganisms – bacteroides and clostridia, this supplement caused a slight increase in the number of bacteroides – by 8.64% and the number of clostridia – by 11.54% on the 14th day. The content of fungi of the Candida genus on the 7th and 14th day increased by 8.3%.\u0000Conclusions. In the 2nd period of the study, the microbiome of intestinal contents worsened: the process of dysbacteriosis increased, which was manifested by a significant increase in the number of Proteus spp., Staphylococcus aureus, anaerobes (bacteroides, clostridia) and Candida spp., as well as decreased Escherichia coli and Enterococci.","PeriodicalId":14059,"journal":{"name":"International Journal of Medicine and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42022390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-18DOI: 10.11603/ijmmr.2413-6077.2021.2.12636
G. Soni, S. Jain, P. Rathi, P. Goswami
Background. An inappropriate prescribing pattern of antimigraine drugs by doctors may often encourage inappropriate self-medication by patients because of the asymmetry of medical information. Objective. The study is aimed to assess the current trends in prescribing patterns of anti-migraine drugs, rationality of prescription, and pattern of migraine severity in patients of migraine. Methods. A cross sectional study was conducted at a tertiary care teaching hospital. All the prescribing details including patient’s demographic details, diagnosis, details of drug therapy (drug name, dose, duration, and frequency) were recorded. Rationality of prescription was assessed using the WHO core drug prescribing indicators and the pattern of severity of migraine was assessed using MIDAS scoring system. Results. Out of 85 patients, 71 were female (83.5%), mostly around 21-30 years of age, and 27 (31.7%) patients had other comorbidities. Naproxen was the most commonly used NSAID for termination of acute migraine attack (15.3 %). The most common drugs prescribed for prophylaxis included beta adrenergic blockers (Propranolol, 14.66%), antidepressants (Amitriptyline, 9.33% and Fluoxetine 3.33%), and antipsychotics (Prochlorperazine, 4.66%). Domperidone (17.30%) was the most commonly prescribed antiemetic. Prescription of triptans was low (2.66%) with Rizatriptan as the most commonly prescribed triptan. Conclusions. The current study revealed that further improvements are required in prescribing practices especially in average number of drugs per prescription, prescription of drugs with generic names, and prescription of drugs of the essential drugs list.
{"title":"CURRENT TRENDS IN PRESCRIBING PATTERN OF ANTI-MIGRAINE DRUGS IN PATIENTS OF MIGRAINE AT A TERTIARY CARE TEACHING HOSPITAL","authors":"G. Soni, S. Jain, P. Rathi, P. Goswami","doi":"10.11603/ijmmr.2413-6077.2021.2.12636","DOIUrl":"https://doi.org/10.11603/ijmmr.2413-6077.2021.2.12636","url":null,"abstract":"Background. An inappropriate prescribing pattern of antimigraine drugs by doctors may often encourage inappropriate self-medication by patients because of the asymmetry of medical information.\u0000Objective. The study is aimed to assess the current trends in prescribing patterns of anti-migraine drugs, rationality of prescription, and pattern of migraine severity in patients of migraine. \u0000Methods. A cross sectional study was conducted at a tertiary care teaching hospital. All the prescribing details including patient’s demographic details, diagnosis, details of drug therapy (drug name, dose, duration, and frequency) were recorded. Rationality of prescription was assessed using the WHO core drug prescribing indicators and the pattern of severity of migraine was assessed using MIDAS scoring system. \u0000Results. Out of 85 patients, 71 were female (83.5%), mostly around 21-30 years of age, and 27 (31.7%) patients had other comorbidities. Naproxen was the most commonly used NSAID for termination of acute migraine attack (15.3 %). The most common drugs prescribed for prophylaxis included beta adrenergic blockers (Propranolol, 14.66%), antidepressants (Amitriptyline, 9.33% and Fluoxetine 3.33%), and antipsychotics (Prochlorperazine, 4.66%). Domperidone (17.30%) was the most commonly prescribed antiemetic. Prescription of triptans was low (2.66%) with Rizatriptan as the most commonly prescribed triptan. \u0000Conclusions. The current study revealed that further improvements are required in prescribing practices especially in average number of drugs per prescription, prescription of drugs with generic names, and prescription of drugs of the essential drugs list.","PeriodicalId":14059,"journal":{"name":"International Journal of Medicine and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43979897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-18DOI: 10.11603/ijmmr.2413-6077.2021.2.12675
L. Romanyuk, I. Volch, N. Kravets, T. I. Pyatkovskyy, O. M. Zahrychuk
Background. In December 2019 first case of COVID-19 was first registered in Wuhan, Hubei province, China. This infectious disease primarily causes respiratory tract infection, but can also affect the other organs and systems. Objective. In this study, the features of the gender-age structure and comorbid pathology of the patients with viral and bacterial pneumonia who were treated in inpatient department in the period from September to December 2020 are summarized. Methods. The research was conducted in Ternopil Municipal Hospital No. 3, Ternopil, Ukraine. Clinical cases of 262 patients with viral and bacterial pneumonia associated with COVID-19 were studied retrospectively. Results. Both men and women has been affected by this pathology in Ternopil region with the same frequency in contrast with the established fact that men are less resistant to infections that women. Most of the patients ranged in age from 51 to 70 years, however, a fair number of patients were over the age of 70 years. Concomitant pathology was diagnosed in 65.5% of the patients with coronavirus infection. Coronary heart disease (34.5%) is leading in the structure of comorbid conditions. Conclusions. During the COVID-19 pandemic, timely diagnosis and medical care of the patients over 50 years of age is of great importance. The analysis of concomitant pathology proves that the people with cardiovascular pathology are in the increased risk group.
{"title":"RETROSPECTIVE ANALYSIS OF GENDER-AGE STRUCTURE AND COMORBID PATHOLOGY OF PATIENTS WITH VIRAL AND BACTERIAL PNEUMONIA ASSOCIATED WITH COVID-19","authors":"L. Romanyuk, I. Volch, N. Kravets, T. I. Pyatkovskyy, O. M. Zahrychuk","doi":"10.11603/ijmmr.2413-6077.2021.2.12675","DOIUrl":"https://doi.org/10.11603/ijmmr.2413-6077.2021.2.12675","url":null,"abstract":"Background. In December 2019 first case of COVID-19 was first registered in Wuhan, Hubei province, China. This infectious disease primarily causes respiratory tract infection, but can also affect the other organs and systems. \u0000Objective. In this study, the features of the gender-age structure and comorbid pathology of the patients with viral and bacterial pneumonia who were treated in inpatient department in the period from September to December 2020 are summarized.\u0000Methods. The research was conducted in Ternopil Municipal Hospital No. 3, Ternopil, Ukraine. Clinical cases of 262 patients with viral and bacterial pneumonia associated with COVID-19 were studied retrospectively. \u0000Results. Both men and women has been affected by this pathology in Ternopil region with the same frequency in contrast with the established fact that men are less resistant to infections that women. Most of the patients ranged in age from 51 to 70 years, however, a fair number of patients were over the age of 70 years. Concomitant pathology was diagnosed in 65.5% of the patients with coronavirus infection. Coronary heart disease (34.5%) is leading in the structure of comorbid conditions. \u0000Conclusions. During the COVID-19 pandemic, timely diagnosis and medical care of the patients over 50 years of age is of great importance. The analysis of concomitant pathology proves that the people with cardiovascular pathology are in the increased risk group.","PeriodicalId":14059,"journal":{"name":"International Journal of Medicine and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43603491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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