Pub Date : 2020-02-26DOI: 10.11603/ijmmr.2413-6077.2019.2.10897
M. Horyn, L. Logoyda
Background. Analytical method is increasingly implemented into fundamental pharmaceutical chemistry and analysis, considering their high sensitivity, accuracy, specificity and expressiveness. Objective. Metoprolol’s analytical method development was the research goal. Methods. The sources were world recognized journals (1990-2019) and key words used as filter were “metoprolol”, “spectrophotometry” “high-performance liquid chromatography, HPLC”, “quantitative analysis”, “validation”. Results. Chromatographic methods of analysis have the highest specificity and objectivity and allow qualitative and quantitative determination of Active Pharmaceutic Ingredient (API) in combined dosage forms and biological fluids without prior components separation. The main disadvantage of the described API analysis methods is long terms from the beginning of chromatography to API release and specific solvents used as the mobile phase in HPLC. New methods development and selection such chromatographic conditions that provide high speed and high efficiency at lower pressure of the system are essential. Also, the reduction of analysis time is achieved by simplifying the conditions for sample preparation. Conclusions. Analysts are constantly working on developing new analysis methods and their optimization in order to save time and consumables, which also ensures the efficiency of the developed method. There is no monograph on the substance or dosage forms of metoprolol in SPhU. Therefore, some of the developed methods should be suggested for the SPhU monograph, which is important for ensuring pharmacopoeial quality control of medicines in Ukraine.
{"title":"METHODS OF METOPROLOL ANALYSIS IN DRUGS AND BIOLOGICAL FLUIDS: REVIEW AND SUGGESTIONS","authors":"M. Horyn, L. Logoyda","doi":"10.11603/ijmmr.2413-6077.2019.2.10897","DOIUrl":"https://doi.org/10.11603/ijmmr.2413-6077.2019.2.10897","url":null,"abstract":"Background. Analytical method is increasingly implemented into fundamental pharmaceutical chemistry and analysis, considering their high sensitivity, accuracy, specificity and expressiveness. Objective. Metoprolol’s analytical method development was the research goal. Methods. The sources were world recognized journals (1990-2019) and key words used as filter were “metoprolol”, “spectrophotometry” “high-performance liquid chromatography, HPLC”, “quantitative analysis”, “validation”. Results. Chromatographic methods of analysis have the highest specificity and objectivity and allow qualitative and quantitative determination of Active Pharmaceutic Ingredient (API) in combined dosage forms and biological fluids without prior components separation. The main disadvantage of the described API analysis methods is long terms from the beginning of chromatography to API release and specific solvents used as the mobile phase in HPLC. New methods development and selection such chromatographic conditions that provide high speed and high efficiency at lower pressure of the system are essential. Also, the reduction of analysis time is achieved by simplifying the conditions for sample preparation. Conclusions. Analysts are constantly working on developing new analysis methods and their optimization in order to save time and consumables, which also ensures the efficiency of the developed method. There is no monograph on the substance or dosage forms of metoprolol in SPhU. Therefore, some of the developed methods should be suggested for the SPhU monograph, which is important for ensuring pharmacopoeial quality control of medicines in Ukraine.","PeriodicalId":14059,"journal":{"name":"International Journal of Medicine and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43171025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-26DOI: 10.11603/ijmmr.2413-6077.2019.2.10894
S. Kostiv, D. V. Khvalyboha, I. K. Venher, O. Zarudna, O. I. Kostiv
Вступ. Частота венозних тромбоемболічних ускладнень в хірургічній практиці досить висока. У багатьох випадках це причина летальної тромбоемболії легеневої артерії. Одним з актуальних завдань ультразвукової діагностики гострого венозного тромбозу є візуальна оцінка субстрату захворювання, оскільки він визначає ангіохірургічну тактику та хірургічну профілактику тромбоемболії легень. Метою дослідження було запобігти розвитку тромбоемболії легеневої артерії у пацієнтів із післяопераційним венозним тромбозом системи нижньої порожнистої вени. Методи дослідження. Дослідження системи порожнистої вени та визначення соноеластографічних властивостей венозного тромбу проводили за допомогою ультразвукової системи Siemens Acuson S2000. Встановлено локалізацію та поширеність тромботичного процесу. Наприкінці актуального діагнозу венозного тромбу вивчали соноеластографічні властивості тромбу шляхом визначення швидкості поширення акустичної хвилі. Результати й обговорення. Робота заснована на результатах обстеження та хірургічного лікування 729 пацієнтів, з них 205 (28,12%) оперативних втручань на опорно-руховому апараті, 378 (51,85%) – на органах черевної порожнини, 146 (20,01%) – реконструктивна хірургія на аорті та основних артеріях нижніх кінцівок. Висновки. Емболонебезпечні тромби – це венозні тромби системи нижньої порожнистої вени, які при ультрасоноеластографії проксимальних сегментів венозного тромбу характеризуються швидкістю поширення акустичної хвилі в межах 2,5–2,8 м / с. Виявлення емболічного венозного тромбозу є показанням до хірургічних методів профілактики тромбоемболії легеневої артерії.
{"title":"УЛЬТРАЗВУКОВА ТРОМБОЕЛАСТОГРАФІЯ У ВИБОРІ ЛІКУВАННЯ ХВОРИХ З ПІСЛЯОПЕРАЦІЙНИМ ВЕНОЗНИМ ТРОМБОЗОМ","authors":"S. Kostiv, D. V. Khvalyboha, I. K. Venher, O. Zarudna, O. I. Kostiv","doi":"10.11603/ijmmr.2413-6077.2019.2.10894","DOIUrl":"https://doi.org/10.11603/ijmmr.2413-6077.2019.2.10894","url":null,"abstract":"Вступ. Частота венозних тромбоемболічних ускладнень в хірургічній практиці досить висока. У багатьох випадках це причина летальної тромбоемболії легеневої артерії. Одним з актуальних завдань ультразвукової діагностики гострого венозного тромбозу є візуальна оцінка субстрату захворювання, оскільки він визначає ангіохірургічну тактику та хірургічну профілактику тромбоемболії легень. \u0000Метою дослідження було запобігти розвитку тромбоемболії легеневої артерії у пацієнтів із післяопераційним венозним тромбозом системи нижньої порожнистої вени. \u0000Методи дослідження. Дослідження системи порожнистої вени та визначення соноеластографічних властивостей венозного тромбу проводили за допомогою ультразвукової системи Siemens Acuson S2000. Встановлено локалізацію та поширеність тромботичного процесу. Наприкінці актуального діагнозу венозного тромбу вивчали соноеластографічні властивості тромбу шляхом визначення швидкості поширення акустичної хвилі. \u0000Результати й обговорення. Робота заснована на результатах обстеження та хірургічного лікування 729 пацієнтів, з них 205 (28,12%) оперативних втручань на опорно-руховому апараті, 378 (51,85%) – на органах черевної порожнини, 146 (20,01%) – реконструктивна хірургія на аорті та основних артеріях нижніх кінцівок. \u0000Висновки. Емболонебезпечні тромби – це венозні тромби системи нижньої порожнистої вени, які при ультрасоноеластографії проксимальних сегментів венозного тромбу характеризуються швидкістю поширення акустичної хвилі в межах 2,5–2,8 м / с. Виявлення емболічного венозного тромбозу є показанням до хірургічних методів профілактики тромбоемболії легеневої артерії.","PeriodicalId":14059,"journal":{"name":"International Journal of Medicine and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42002440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-26DOI: 10.11603/ijmmr.2413-6077.2019.2.10898
I. Drapak
Background. QSAR analysis is an important tool for the identification of pharmacophore fragments in biologically active substances and helps optimize the search for new effective drugs. Objective. The aim of the study was to determine the molecular descriptors for QSAR analysis of polysubstituted functionalized aminothiazoles as a theoretical basis for purposeful search de novo of potential antihypertensive drugs among the investigated compounds. Methods. Calculation of molecular descriptors and QSAR-models creation was carried out using the HyperChem 7.5 and BuildQSAR packages. Results. The calculation of a number of molecular descriptors (electronic, steric, geometric, energy) was performed for 15 new polysubstituted functionalized aminothiazoles, with established in vivo antihypertensive activity. According to the calculated molecular descriptors and antihypertensive activity parameter, the QSAR models were derived НА = a + b ∙ X1 + c ∙ X2 + d ∙ X3 , where the activity parameter НА is antihypertensive activity and X1, X2, X3 are molecular descriptors. Conclusion. The study of ‘the structure antihypertensive activity’ relationship for polysubstituted functionalized aminothiazoles was carried out. QSAR analysis revealed that volume, area, lipophilicity, dipole moment, refractivity, polarization of the molecule and energy of the lowest unoccupied molecular orbital have the most significant effect on antihypertensive activity. It was suggested that the attained QSAR-models may have antihypertensive activity within abovementioned row of compounds and can be considered as theoretical basis for de novo design of new potential antihypertensive drugs.
{"title":"QSAR-ANALYSIS OF POLYSUBSTITUTED FUNCTIONALIZED AMINOTHIAZOLES WITH ANTIHYPERTENSIVE ACTIVITY","authors":"I. Drapak","doi":"10.11603/ijmmr.2413-6077.2019.2.10898","DOIUrl":"https://doi.org/10.11603/ijmmr.2413-6077.2019.2.10898","url":null,"abstract":"Background. QSAR analysis is an important tool for the identification of pharmacophore fragments in biologically active substances and helps optimize the search for new effective drugs. Objective. The aim of the study was to determine the molecular descriptors for QSAR analysis of polysubstituted functionalized aminothiazoles as a theoretical basis for purposeful search de novo of potential antihypertensive drugs among the investigated compounds. Methods. Calculation of molecular descriptors and QSAR-models creation was carried out using the HyperChem 7.5 and BuildQSAR packages. Results. The calculation of a number of molecular descriptors (electronic, steric, geometric, energy) was performed for 15 new polysubstituted functionalized aminothiazoles, with established in vivo antihypertensive activity. According to the calculated molecular descriptors and antihypertensive activity parameter, the QSAR models were derived НА = a + b ∙ X1 + c ∙ X2 + d ∙ X3 , where the activity parameter НА is antihypertensive activity and X1, X2, X3 are molecular descriptors. Conclusion. The study of ‘the structure antihypertensive activity’ relationship for polysubstituted functionalized aminothiazoles was carried out. QSAR analysis revealed that volume, area, lipophilicity, dipole moment, refractivity, polarization of the molecule and energy of the lowest unoccupied molecular orbital have the most significant effect on antihypertensive activity. It was suggested that the attained QSAR-models may have antihypertensive activity within abovementioned row of compounds and can be considered as theoretical basis for de novo design of new potential antihypertensive drugs.","PeriodicalId":14059,"journal":{"name":"International Journal of Medicine and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46281495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-19DOI: 10.11603/ijmmr.2413-6077.2019.2.10886
U. Mudra
Background. Gout is still one of the major health problems despite significant advances in treatment in recent years. It has been proved that pathogenetic mechanisms of development and progression of gout are associated with nonalcoholic fatty liver disease. Complex pathogenic treatment of patients aimed at different parts of the pathological process has recently been supplemented with the enterosorbents. Objective. The aim of the research is to study the clinical features of gout with concomitant nonalcoholic fatty liver disease (NAFLD) and to evaluate the effect of carbon enterosorbent on its course. Methods. 123 patients were involved in the study. They were divided into 2 groups: group 1 included patients with gout without liver damage, and group 2 included patients with concomitant NAFLD. Each of these groups was divided into subgroups, in which the patients received carbon enterosorbent carboline plus basic treatment. The control group consisted of 30 healthy persons. Anamnesis, physical examination, uric acid (UA), C-reactive protein (CRP) content, erythrocyte sedimentation rate (ESR) in serum were determined. Gout activity was evaluated using the Gout Activity Score (GAS). Results. Basic treatment in combination with carbon enterosorbent contributed to faster cure of intoxication, pain and joint syndromes, as well as decrease of the inflammatory process activity. Conclusions. The course of gout in the patients with concomitant NAFLD is more severe. Adding of carbon granular enterosorbent carboline in the complex treatment of patients with gout with or without concomitant NAFLD in the exacerbation phase contributes to a faster cureing dynamics of clinical and laboratory manifestations of the disease.
{"title":"GOUT AND NONALCOHOLIC FATTY LIVER DISEASE: EFFECT OF ENTEROSORPTION’S ADDITION TO COMMON TREATMENT","authors":"U. Mudra","doi":"10.11603/ijmmr.2413-6077.2019.2.10886","DOIUrl":"https://doi.org/10.11603/ijmmr.2413-6077.2019.2.10886","url":null,"abstract":"Background. Gout is still one of the major health problems despite significant advances in treatment in recent years. It has been proved that pathogenetic mechanisms of development and progression of gout are associated with nonalcoholic fatty liver disease. Complex pathogenic treatment of patients aimed at different parts of the pathological process has recently been supplemented with the enterosorbents. Objective. The aim of the research is to study the clinical features of gout with concomitant nonalcoholic fatty liver disease (NAFLD) and to evaluate the effect of carbon enterosorbent on its course. Methods. 123 patients were involved in the study. They were divided into 2 groups: group 1 included patients with gout without liver damage, and group 2 included patients with concomitant NAFLD. Each of these groups was divided into subgroups, in which the patients received carbon enterosorbent carboline plus basic treatment. The control group consisted of 30 healthy persons. Anamnesis, physical examination, uric acid (UA), C-reactive protein (CRP) content, erythrocyte sedimentation rate (ESR) in serum were determined. Gout activity was evaluated using the Gout Activity Score (GAS). Results. Basic treatment in combination with carbon enterosorbent contributed to faster cure of intoxication, pain and joint syndromes, as well as decrease of the inflammatory process activity. Conclusions. The course of gout in the patients with concomitant NAFLD is more severe. Adding of carbon granular enterosorbent carboline in the complex treatment of patients with gout with or without concomitant NAFLD in the exacerbation phase contributes to a faster cureing dynamics of clinical and laboratory manifestations of the disease.","PeriodicalId":14059,"journal":{"name":"International Journal of Medicine and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49333498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-18DOI: 10.11603/ijmmr.2413-6077.2019.2.10310
V. Dzhyvak, O. Khlibovska, I. Klishch
Background. Endogenous intoxication is a multicomponent complex process due to the endogenous biological products or dysfunction of systemic natural detoxification. Objective. The aim of the research was to study the dynamics of indices of endogenous intoxication in rats with traumatic muscle damage in the experiment. Methods. The experiment was performed on 45 non-linear white rats, which were modeled with traumatic muscle damage. The level of endogenous intoxication was assessed by the content of medium plasma molecules (MMM), leukocyte and erythrocytic index of intoxication (LII and EII). The research was conducted on the 1st, 3rd, 7th, 14th days after the injury. Results. It was found that traumatic muscle damage causes endotoxemia. Manifestations of endogenous intoxication are: the increase of MMM1 in 2.3 times, MMM2 in 2.8 times compare to the intact animals. The level of this indicator slightly decreased in 7 days. Simultaneously with an increase in the MCT level in the post-traumatic period, the total toxic effect on the erythrocyte membrane also increased, which was manifested by a significant increase in EII in all terms of observation. Conclusions. Traumatic damage of the muscles is accompanied by the growth of molecules of average mass in upto 7 days of observation, which significantly differ from the indicators of the intact group. The results of our research prove that traumatic muscle damage causes endotoxicosis development evidenced by accumulation of endotoxins in the animals’ body that is proved by significant changes in endogenous intoxication indices: i.e. erythrocytic and leukocytic indexes of intoxication and content of medium mass molecules.
{"title":"ROLE OF ENDOGENIC INTOXICATION IN MUSCLE INJURY IN EXPERIMENT","authors":"V. Dzhyvak, O. Khlibovska, I. Klishch","doi":"10.11603/ijmmr.2413-6077.2019.2.10310","DOIUrl":"https://doi.org/10.11603/ijmmr.2413-6077.2019.2.10310","url":null,"abstract":"Background. Endogenous intoxication is a multicomponent complex process due to the endogenous biological products or dysfunction of systemic natural detoxification. Objective. The aim of the research was to study the dynamics of indices of endogenous intoxication in rats with traumatic muscle damage in the experiment. Methods. The experiment was performed on 45 non-linear white rats, which were modeled with traumatic muscle damage. The level of endogenous intoxication was assessed by the content of medium plasma molecules (MMM), leukocyte and erythrocytic index of intoxication (LII and EII). The research was conducted on the 1st, 3rd, 7th, 14th days after the injury. Results. It was found that traumatic muscle damage causes endotoxemia. Manifestations of endogenous intoxication are: the increase of MMM1 in 2.3 times, MMM2 in 2.8 times compare to the intact animals. The level of this indicator slightly decreased in 7 days. Simultaneously with an increase in the MCT level in the post-traumatic period, the total toxic effect on the erythrocyte membrane also increased, which was manifested by a significant increase in EII in all terms of observation. Conclusions. Traumatic damage of the muscles is accompanied by the growth of molecules of average mass in upto 7 days of observation, which significantly differ from the indicators of the intact group. The results of our research prove that traumatic muscle damage causes endotoxicosis development evidenced by accumulation of endotoxins in the animals’ body that is proved by significant changes in endogenous intoxication indices: i.e. erythrocytic and leukocytic indexes of intoxication and content of medium mass molecules.","PeriodicalId":14059,"journal":{"name":"International Journal of Medicine and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44822056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-18DOI: 10.11603/ijmmr.2413-6077.2019.2.10388
T. Irinyenikan
Background. The inability of couples to achieve pregnancy is a major cause of psycho-social problems in family relationship that could lead to marital disharmony. Objective. The aim of this study was to find out the possible risk factors for female infertility. Methods. A case-control design and a sample size of 400 (200 cases of infertility and 200 controls) were used in the study. Cases and controls were selected at random at the infertility and family planning clinic of the University of Medical Sciences Teaching Hospital Complex, Akure and were subjected to a predesigned interviewer administered questionnaire to collect the data. The cases were classified into primary and secondary infertility; binary and stepwise logistic regressions were used to generate the Odds ratio and 95% confidence interval of the possible risk factors and the level of significance was set at P<0.05. Results. The mean age of the women with infertility was 28.5±5.43 years and the mean age of those in the control group was 29.1±5.62 years. Among the cases, 155 (77.5%) had secondary infertility, while 45 (22.5%) had primary infertility. Significant risk factors for female infertility included presence of fibroids, having had fibroid operation, multiple sexual partners, previous abortion, polycystic ovary syndrome (PCOS), sexually transmitted infection (STI) and post abortion sepsis. Conclusion. The study showed that secondary infertility is still the most prevalent and the risk factors were multi factorial. Efforts should be intensified to reduce infertility due to preventable causes.
{"title":"RISK FACTORS FOR FEMALE INFERTILITY AT A TERTIARY HEALTH FACILITY IN AKURE, SOUTH-WEST NIGERIA","authors":"T. Irinyenikan","doi":"10.11603/ijmmr.2413-6077.2019.2.10388","DOIUrl":"https://doi.org/10.11603/ijmmr.2413-6077.2019.2.10388","url":null,"abstract":"Background. The inability of couples to achieve pregnancy is a major cause of psycho-social problems in family relationship that could lead to marital disharmony. Objective. The aim of this study was to find out the possible risk factors for female infertility. Methods. A case-control design and a sample size of 400 (200 cases of infertility and 200 controls) were used in the study. Cases and controls were selected at random at the infertility and family planning clinic of the University of Medical Sciences Teaching Hospital Complex, Akure and were subjected to a predesigned interviewer administered questionnaire to collect the data. The cases were classified into primary and secondary infertility; binary and stepwise logistic regressions were used to generate the Odds ratio and 95% confidence interval of the possible risk factors and the level of significance was set at P<0.05. Results. The mean age of the women with infertility was 28.5±5.43 years and the mean age of those in the control group was 29.1±5.62 years. Among the cases, 155 (77.5%) had secondary infertility, while 45 (22.5%) had primary infertility. Significant risk factors for female infertility included presence of fibroids, having had fibroid operation, multiple sexual partners, previous abortion, polycystic ovary syndrome (PCOS), sexually transmitted infection (STI) and post abortion sepsis. Conclusion. The study showed that secondary infertility is still the most prevalent and the risk factors were multi factorial. Efforts should be intensified to reduce infertility due to preventable causes.","PeriodicalId":14059,"journal":{"name":"International Journal of Medicine and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46393809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-18DOI: 10.11603/ijmmr.2413-6077.2019.2.10456
K. Rajmohan, Inam Danish Khan, U. Kapoor, Syed Asif Hashmi, R. Gupta, S. Sen, G. Nair, K. Singh, K. Tandel, M. Malik
Background. Aspergillus is an inherently ubiquitous, weakly pathogenic fungus causing opportunistic infections. It is very rarely localized in the larynx, although laryngeal Aspergillosis may develop in the immunocompromised patients including those with leukaemia and severe aplastic anaemia. Objective. The aim of the research was to explore the primary laryngeal Aspergillosis in an immunocompetent patient thru a case report. Methods. A case report of primary laryngeal Aspergillosis in an immunocompetent patient is presented. Results. A male patient of 40 years old, presenting with chronic worsening hoarseness, was found to have a smooth, white spheroid submucosal growth on left vocal cord with preserved bilateral cord movements on videostroboscopy. Histopathological examination of vocal cord growth revealed squamous epithelium containing septate hyphae with acute angle dichotomous branching pattern consistent with Aspergillus. Voice improved after a four-week course of oral itraconazole 200 mg/day. Post therapy follow up of 24 months was unremarkable. Conclusions. Primary laryngeal Aspergillosis develops in the immunocompetent patients. Iatrogenic, vocal abuse, occupation and lifestyle factors may be contributory. Optimal diagnosis and management mandates a high index of suspicion.
{"title":"PRIMARY LARYNGEAL ASPERGILLOSIS IN AN IMMUNOCOMPETENT PATIENT","authors":"K. Rajmohan, Inam Danish Khan, U. Kapoor, Syed Asif Hashmi, R. Gupta, S. Sen, G. Nair, K. Singh, K. Tandel, M. Malik","doi":"10.11603/ijmmr.2413-6077.2019.2.10456","DOIUrl":"https://doi.org/10.11603/ijmmr.2413-6077.2019.2.10456","url":null,"abstract":"Background. Aspergillus is an inherently ubiquitous, weakly pathogenic fungus causing opportunistic infections. It is very rarely localized in the larynx, although laryngeal Aspergillosis may develop in the immunocompromised patients including those with leukaemia and severe aplastic anaemia. \u0000Objective. The aim of the research was to explore the primary laryngeal Aspergillosis in an immunocompetent patient thru a case report. \u0000Methods. A case report of primary laryngeal Aspergillosis in an immunocompetent patient is presented. \u0000Results. A male patient of 40 years old, presenting with chronic worsening hoarseness, was found to have a smooth, white spheroid submucosal growth on left vocal cord with preserved bilateral cord movements on videostroboscopy. Histopathological examination of vocal cord growth revealed squamous epithelium containing septate hyphae with acute angle dichotomous branching pattern consistent with Aspergillus. Voice improved after a four-week course of oral itraconazole 200 mg/day. Post therapy follow up of 24 months was unremarkable. \u0000Conclusions. Primary laryngeal Aspergillosis develops in the immunocompetent patients. Iatrogenic, vocal abuse, occupation and lifestyle factors may be contributory. Optimal diagnosis and management mandates a high index of suspicion.","PeriodicalId":14059,"journal":{"name":"International Journal of Medicine and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46075592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-18DOI: 10.11603/ijmmr.2413-6077.2019.2.10609
S. Vadzyuk, L. Horban, I. Papinko
Background. The individual and typological features of the central nervous system are interpreted as highly genetically determined. Each somatotype is characterized by morphofunctional features of the activity of different systems, including the circulatory system. Objective. The aim of the research was to study the features of the main individual and typological parameters of higher nervous activity in persons of different somatotype with normal and high blood pressure (BP). Methods. In the control group of the surveyed patients the BP value corresponded to the optimal level according to the WHO classification (125 people). The second group consisted of individuals, whose systolic blood pressure exceeded 130 mmHg at the time of the study and (or) diastolic – 85 mmHg (135 people). Somatotyping technique by Carter and Heath was used. Functional mobility (FMNP) and strength of nervous processes (SNP) were determined using the Diagnost-1 program (Makarenko and Lizogub). Results. In the individuals with predominance of ecto- and mesomorphic somatotype component, higher levels of major nervous processes were reported in response to strenuous processing of information, which was associated with more advanced mechanisms of information processing, its neurophysiological support. In people with endomorphic somatotype the lower levels of FMNP and SNP were clearly detected that could indicate that the speed characteristics of the nervous processes in them are at a lower level. Conclusions. In normal blood pressure, the highest indicator of FMNP was found in the individuals with predominance of ecto- and mesomorphic component. In the group with high blood pressure, the indicator at the level below the average was in endomorphs. Predominance of the ectomorphic component tended to increase in the surveyed, and in the mesomorphs was at the average level. The lowest level of SNP was found in the individuals with endomorphic somatotype of both groups.
{"title":"MAIN INDIVIDUAL AND TYPOLOGICAL PARAMETERS OF HIGHER NERVOUS ACTIVITY IN YOUNG PEOPLE OF DIFFERENT SOMATOTYPE WITH NORMAL AND HIGH BLOOD PRESSURE","authors":"S. Vadzyuk, L. Horban, I. Papinko","doi":"10.11603/ijmmr.2413-6077.2019.2.10609","DOIUrl":"https://doi.org/10.11603/ijmmr.2413-6077.2019.2.10609","url":null,"abstract":"Background. The individual and typological features of the central nervous system are interpreted as highly genetically determined. Each somatotype is characterized by morphofunctional features of the activity of different systems, including the circulatory system.\u0000Objective. The aim of the research was to study the features of the main individual and typological parameters of higher nervous activity in persons of different somatotype with normal and high blood pressure (BP).\u0000Methods. In the control group of the surveyed patients the BP value corresponded to the optimal level according to the WHO classification (125 people). The second group consisted of individuals, whose systolic blood pressure exceeded 130 mmHg at the time of the study and (or) diastolic – 85 mmHg (135 people). Somatotyping technique by Carter and Heath was used. Functional mobility (FMNP) and strength of nervous processes (SNP) were determined using the Diagnost-1 program (Makarenko and Lizogub).\u0000Results. In the individuals with predominance of ecto- and mesomorphic somatotype component, higher levels of major nervous processes were reported in response to strenuous processing of information, which was associated with more advanced mechanisms of information processing, its neurophysiological support. In people with endomorphic somatotype the lower levels of FMNP and SNP were clearly detected that could indicate that the speed characteristics of the nervous processes in them are at a lower level.\u0000Conclusions. In normal blood pressure, the highest indicator of FMNP was found in the individuals with predominance of ecto- and mesomorphic component. In the group with high blood pressure, the indicator at the level below the average was in endomorphs. Predominance of the ectomorphic component tended to increase in the surveyed, and in the mesomorphs was at the average level. The lowest level of SNP was found in the individuals with endomorphic somatotype of both groups.","PeriodicalId":14059,"journal":{"name":"International Journal of Medicine and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44351226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-18DOI: 10.11603/ijmmr.2413-6077.2019.2.10334
G. Huwiage, A. Nami, A. Akadh
Background. Helicobacter pylori is the most common infection in the world. Relationship between H. pylori and dyspepsia was confirmed by many studies, it has been strongly associated with peptic ulcer disease and gastric cancer. In that respect, several invasive and noninvasive methods for the diagnosis of H. pylori infection were utilized. Objective. The aim of the study was to evaluate the association between dyspepsia and the positivity of H. pylori stool antigen test, to compare this test with serological IgG test. Methods. 125 adult patients were randomly selected from gastroenterology units of Mediterranean and Tajurah clinics in Tripoli. Stool samples were taken for detection of H. pylori antigen by enzyme immunoassay. Blood samples for detection of anti-H. pylori IgG antibodies were taken. Data were statistically analyzed using SPSS. Results. 125 dyspeptic patients: 47 male and 78 female, aged 18-83 years old were examined. 80 patients were infected by H. pylori that was proved by a positive stool test, 88 had a positive IgG test. The prevalence was higher in the patients aged 28-47 years old. There was substantial relation to age, marital status and economic risk factors; there was no association between H. pylori and gender, sources of drinking water, living standards, smoking, family history of peptic ulcer, drug consumption, and blood groups. Conclusions. Relatively high rates of detection by HpSA prove that stool testing might be a reliable, simple, inexpensive, and non-invasive alternative test ащк detectшщт of H. pylori, diagnosing active infection and confirming cure. However IgG test has a low sensitivity, specificity, and accuracy compare to the HpSA test. Thus it can be used for screening purposes.
{"title":"STOOL ANTIGEN (HPSA) TEST IN DETECTION OF HELICOBACTER PYLORI INFECTION AMONG ADULT DYSPEPTIC PATIENTS IN TRIPOLI, LIBYA","authors":"G. Huwiage, A. Nami, A. Akadh","doi":"10.11603/ijmmr.2413-6077.2019.2.10334","DOIUrl":"https://doi.org/10.11603/ijmmr.2413-6077.2019.2.10334","url":null,"abstract":"Background. Helicobacter pylori is the most common infection in the world. Relationship between H. pylori and dyspepsia was confirmed by many studies, it has been strongly associated with peptic ulcer disease and gastric cancer. In that respect, several invasive and noninvasive methods for the diagnosis of H. pylori infection were utilized. Objective. The aim of the study was to evaluate the association between dyspepsia and the positivity of H. pylori stool antigen test, to compare this test with serological IgG test. Methods. 125 adult patients were randomly selected from gastroenterology units of Mediterranean and Tajurah clinics in Tripoli. Stool samples were taken for detection of H. pylori antigen by enzyme immunoassay. Blood samples for detection of anti-H. pylori IgG antibodies were taken. Data were statistically analyzed using SPSS. Results. 125 dyspeptic patients: 47 male and 78 female, aged 18-83 years old were examined. 80 patients were infected by H. pylori that was proved by a positive stool test, 88 had a positive IgG test. The prevalence was higher in the patients aged 28-47 years old. There was substantial relation to age, marital status and economic risk factors; there was no association between H. pylori and gender, sources of drinking water, living standards, smoking, family history of peptic ulcer, drug consumption, and blood groups. Conclusions. Relatively high rates of detection by HpSA prove that stool testing might be a reliable, simple, inexpensive, and non-invasive alternative test ащк detectшщт of H. pylori, diagnosing active infection and confirming cure. However IgG test has a low sensitivity, specificity, and accuracy compare to the HpSA test. Thus it can be used for screening purposes.","PeriodicalId":14059,"journal":{"name":"International Journal of Medicine and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45299968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-18DOI: 10.11603/ijmmr.2413-6077.2019.2.10448
G. Loban, T. Petrushanko, V. V. Chereda, M. Faustova, M. Ananieva, Ya. O. Basarab
Background. Periodontal tissues inflammatory diseases are widespread among young people. Objective. This study was aimed at elaborating the method to assess risks of periodontal inflammatory diseases and determining its efficacy depending on the state of dental tissues, gum tissues and sex. Methods. The study included 182 students (93 men, 89 women) aged 19-29: 22 individuals had no lesions of hard dental tissues and no signs of periodontal disease; 51 individuals were found to have DMF index <6; 52 individuals – DMF index ≥6; 57 individuals were diagnosed with chronic catarrhal gingivitis. Primary groups were formed in autumn; re-examination was carried in spring. The research participants were assessed for detection of risks of periodontal inflammatory disease by the method developes by the authors (Patent UA 54041). Results. The study revealed that the risk of development of preiodontitis increases in individuals with high caries and gingivitis intensity. In spring, more individuals suffer from microbial imbalance in in the composition of gingival sulcus fluid and decrease in the mean stability coefficient value that indicates an increased risk of inflammatory periodontal disease development. Women were less likely to experience seasonal dysbiotic changes in the gingival sulcus fluid composition compared with men. Conclusions. The method suggested for assessment of the risk of periodontal inflammatory diseases is of high informativeness. It allows clinicians detecting early pre-nosological signs of oral microbiocenosis imbalance that enhances the effectiveness of early diagnosis of inflammatory periodontal diseases.
{"title":"DIAGNOSTIC AND PROGNOSTIC SIGNIFICANCE OF MICROBIAL FLORA IMBALANCE IN GINGIVAL BIOFILM","authors":"G. Loban, T. Petrushanko, V. V. Chereda, M. Faustova, M. Ananieva, Ya. O. Basarab","doi":"10.11603/ijmmr.2413-6077.2019.2.10448","DOIUrl":"https://doi.org/10.11603/ijmmr.2413-6077.2019.2.10448","url":null,"abstract":"Background. Periodontal tissues inflammatory diseases are widespread among young people. Objective. This study was aimed at elaborating the method to assess risks of periodontal inflammatory diseases and determining its efficacy depending on the state of dental tissues, gum tissues and sex. Methods. The study included 182 students (93 men, 89 women) aged 19-29: 22 individuals had no lesions of hard dental tissues and no signs of periodontal disease; 51 individuals were found to have DMF index <6; 52 individuals – DMF index ≥6; 57 individuals were diagnosed with chronic catarrhal gingivitis. Primary groups were formed in autumn; re-examination was carried in spring. The research participants were assessed for detection of risks of periodontal inflammatory disease by the method developes by the authors (Patent UA 54041). Results. The study revealed that the risk of development of preiodontitis increases in individuals with high caries and gingivitis intensity. In spring, more individuals suffer from microbial imbalance in in the composition of gingival sulcus fluid and decrease in the mean stability coefficient value that indicates an increased risk of inflammatory periodontal disease development. Women were less likely to experience seasonal dysbiotic changes in the gingival sulcus fluid composition compared with men. Conclusions. The method suggested for assessment of the risk of periodontal inflammatory diseases is of high informativeness. It allows clinicians detecting early pre-nosological signs of oral microbiocenosis imbalance that enhances the effectiveness of early diagnosis of inflammatory periodontal diseases.","PeriodicalId":14059,"journal":{"name":"International Journal of Medicine and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42364864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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