Pub Date : 2020-11-10DOI: 10.11603/ijmmr.2413-6077.2020.1.11501
T. V. Bihunyak, Y. Bondarenko, O. O. Кulyanda, S. M. Charnosh, A. Sverstiuk, K. O. Bihuniak
Background. Chromosomal diseases are the cause of 45-50 % of multiple birth defects. Basic research on mutations is performed using genomic technologies to identify a correlation between genotype and phenotype in aneuploidies and to understand its pathogenesis. Objective. The aim of the research is to study the etiology, pathogenesis of symptoms and diagnostics for patients with Down, Klinefelter, Turner syndromes and double aneuploidies by 21 and sex chromosomes. Methods. A literature review by the keywords “Down syndrome”, “Klinefelter syndrome”, “Turner syndrome”, “double aneuploidy” for the period of 2000-2020 was carried out. Results. Down, Klinefelter and Turner syndromes are the most common aneuploidy among viable newborns. Frequency of meiotic non-disjunction events causing these aneuploidies increases with the age of a woman. Identified genes are responsible for pathogenesis of symptoms in trisomy 21, Turner and Klinefelter syndromes. Diagnostics of chromosomal diseases includes prenatal screening programs and postnatal testing. Conclusions. Cytogenetic variants of Down syndrome are simple complete trisomy 21, translocation form and mosaicism. Trisomy 21 is associated with advanced maternal age. Phenotypic manifestations of Down syndrome are associated with the locus 21q22. The maternal and parental nondisjunction of X-chromosomes in meiosis causes Klinefelter and Turner syndromes. These chromosomal diseases are variants of intersexualism with intermediate chromosomal sex. Down-Klinefelter and Down-Turner syndromes are double aneuploidies. Patients have a Down syndrome phenotype at birth, and signs of Klinefelter and Turner syndromes occur during puberty. Diagnosis of aneuploidy is based on the cytogenetic investigation (karyotyping), DNA analysis, ultrasonography and biochemical markers of chromosomal pathology.
{"title":"CHROMOSOMAL DISEASES IN THE HUMAN PATHOLOGY","authors":"T. V. Bihunyak, Y. Bondarenko, O. O. Кulyanda, S. M. Charnosh, A. Sverstiuk, K. O. Bihuniak","doi":"10.11603/ijmmr.2413-6077.2020.1.11501","DOIUrl":"https://doi.org/10.11603/ijmmr.2413-6077.2020.1.11501","url":null,"abstract":"Background. Chromosomal diseases are the cause of 45-50 % of multiple birth defects. Basic research on mutations is performed using genomic technologies to identify a correlation between genotype and phenotype in aneuploidies and to understand its pathogenesis. Objective. The aim of the research is to study the etiology, pathogenesis of symptoms and diagnostics for patients with Down, Klinefelter, Turner syndromes and double aneuploidies by 21 and sex chromosomes. Methods. A literature review by the keywords “Down syndrome”, “Klinefelter syndrome”, “Turner syndrome”, “double aneuploidy” for the period of 2000-2020 was carried out. Results. Down, Klinefelter and Turner syndromes are the most common aneuploidy among viable newborns. Frequency of meiotic non-disjunction events causing these aneuploidies increases with the age of a woman. Identified genes are responsible for pathogenesis of symptoms in trisomy 21, Turner and Klinefelter syndromes. Diagnostics of chromosomal diseases includes prenatal screening programs and postnatal testing. Conclusions. Cytogenetic variants of Down syndrome are simple complete trisomy 21, translocation form and mosaicism. Trisomy 21 is associated with advanced maternal age. Phenotypic manifestations of Down syndrome are associated with the locus 21q22. The maternal and parental nondisjunction of X-chromosomes in meiosis causes Klinefelter and Turner syndromes. These chromosomal diseases are variants of intersexualism with intermediate chromosomal sex. Down-Klinefelter and Down-Turner syndromes are double aneuploidies. Patients have a Down syndrome phenotype at birth, and signs of Klinefelter and Turner syndromes occur during puberty. Diagnosis of aneuploidy is based on the cytogenetic investigation (karyotyping), DNA analysis, ultrasonography and biochemical markers of chromosomal pathology.","PeriodicalId":14059,"journal":{"name":"International Journal of Medicine and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46703550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-10DOI: 10.11603/ijmmr.2413-6077.2020.1.10978
Inam Danish Khan, M. Brijwal, I. Joshi, B. Singh, B. Poonia, G. Gonimadatala, S. Mangalesh, A. Yadav, H. Rajput, N. Bhuttay
DISSEMINATED HISTOPLASMOSIS LEADING TO HAEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS IN AN IMMUNOCOMPETENT PATIENT (case report) *I.D. Khan1, M. Brijwal2, I. Joshi3, B. Singh1, B. Poonia1, G. Gonimadatala1, S. Mangalesh1, A. Yadav1, H. Rajput1, N. Bhuttay1 1 – ARMY COLLEGE OF MEDICAL SCIENCES AND BASE HOSPITAL, NEW DELHI, INDIA 2 – ALL INDIA INSTITUTE OF MEDICAL SCIENCES, NEW DELHI, INDIA 3 – VELLORE INSTITUTE OF TECHNOLOGY, VELLORE, INDIA
1例免疫功能正常患者的弥散性组织胞浆菌病致噬血细胞性淋巴组织细胞增多症(病例报告)Khan1, M. Brijwal2, I. Joshi3, B. sing1, B. pooni1, G. gonimadatal1, S. mangales1, A. Yadav1, H. Rajput1, N. Bhuttay1 1 -印度新德里陆军医学院和基地医院2 -全印度医学科学研究所，印度新德里3 - VELLORE技术研究所，印度VELLORE
{"title":"DISSEMINATED HISTOPLASMOSIS LEADING TO HAEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS IN AN IMMUNOCOMPETENT PATIENT","authors":"Inam Danish Khan, M. Brijwal, I. Joshi, B. Singh, B. Poonia, G. Gonimadatala, S. Mangalesh, A. Yadav, H. Rajput, N. Bhuttay","doi":"10.11603/ijmmr.2413-6077.2020.1.10978","DOIUrl":"https://doi.org/10.11603/ijmmr.2413-6077.2020.1.10978","url":null,"abstract":"DISSEMINATED HISTOPLASMOSIS LEADING TO HAEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS IN AN IMMUNOCOMPETENT PATIENT (case report) *I.D. Khan1, M. Brijwal2, I. Joshi3, B. Singh1, B. Poonia1, G. Gonimadatala1, S. Mangalesh1, A. Yadav1, H. Rajput1, N. Bhuttay1 1 – ARMY COLLEGE OF MEDICAL SCIENCES AND BASE HOSPITAL, NEW DELHI, INDIA 2 – ALL INDIA INSTITUTE OF MEDICAL SCIENCES, NEW DELHI, INDIA 3 – VELLORE INSTITUTE OF TECHNOLOGY, VELLORE, INDIA","PeriodicalId":14059,"journal":{"name":"International Journal of Medicine and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48639782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-10DOI: 10.11603/ijmmr.2413-6077.2020.1.11008
O. V. Rozenko
Background. In connection with a steady increase of patients with destructive forms of acute pancreatitis, the proportion of which takes from 10-15 to 20-30%, despite of the wide range of treatments for non-biliary necrotizing pancreatitis, the rate of mortality reaches 80-90% in case of infected forms and needs further improvement of therapies. Objective. The purpose of this study is to improve the results of treatment of patients with nonbiliary necrotizing pancreatitis, by optimizing surgical tactics. Methods. The study examined the cases of 120 patients, whose age ranged from 22 to 83 years, including patients under the age of 50 years old who accounted for 60.0%. There were 80 males (66.7%) and 40 females (33.3%). Disease duration up to 24 hours was found in 36 (30.0%) patients, from 25 to 72 hours - in 25 (20.8%) individuals, more than 72 hours - in 49 (49.2%) patients. Results. The research claims in non-necrotizing pancreatitis, left-sided retroperitoneal phlegmon often develops in 64.2% (mortality rate 26.0%) of patients, right-sided in 24.2% (mortality rate 6.8%) of patients, and bilateral - in 11, 6% (mortality rate 64.2%) individuals. Moreover, the highest mortality was observed with a combination of retroperitoneal phlegmon cellulose and abscess of the pancreas and/or omental bursa - 39.1%. Conclusions. The use of various surgical interventions depending on the involvement in the pathological process of various sections of the abdominal cavity/ retroperitoneal space, which made it possible to reduce mortality and hospitalization time of patients in the hospital by 1.5-2 times is proposed.
{"title":"NECROTIZING PANCREATITIS: THE WAYS OF IMPROVEMENT OF SURGICAL TREATMENT","authors":"O. V. Rozenko","doi":"10.11603/ijmmr.2413-6077.2020.1.11008","DOIUrl":"https://doi.org/10.11603/ijmmr.2413-6077.2020.1.11008","url":null,"abstract":"Background. In connection with a steady increase of patients with destructive forms of acute pancreatitis, the proportion of which takes from 10-15 to 20-30%, despite of the wide range of treatments for non-biliary necrotizing pancreatitis, the rate of mortality reaches 80-90% in case of infected forms and needs further improvement of therapies. \u0000Objective. The purpose of this study is to improve the results of treatment of patients with nonbiliary necrotizing pancreatitis, by optimizing surgical tactics. \u0000Methods. The study examined the cases of 120 patients, whose age ranged from 22 to 83 years, including patients under the age of 50 years old who accounted for 60.0%. There were 80 males (66.7%) and 40 females (33.3%). Disease duration up to 24 hours was found in 36 (30.0%) patients, from 25 to 72 hours - in 25 (20.8%) individuals, more than 72 hours - in 49 (49.2%) patients. \u0000Results. The research claims in non-necrotizing pancreatitis, left-sided retroperitoneal phlegmon often develops in 64.2% (mortality rate 26.0%) of patients, right-sided in 24.2% (mortality rate 6.8%) of patients, and bilateral - in 11, 6% (mortality rate 64.2%) individuals. Moreover, the highest mortality was observed with a combination of retroperitoneal phlegmon cellulose and abscess of the pancreas and/or omental bursa - 39.1%. \u0000Conclusions. The use of various surgical interventions depending on the involvement in the pathological process of various sections of the abdominal cavity/ retroperitoneal space, which made it possible to reduce mortality and hospitalization time of patients in the hospital by 1.5-2 times is proposed.","PeriodicalId":14059,"journal":{"name":"International Journal of Medicine and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49005356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-10DOI: 10.11603/ijmmr.2413-6077.2020.1.10893
N. Bobrova, E. Vazhnichaya, G. Loban', M. Faustova, M. Ananieva
Background. S. warneri is a common commensal organism, but it can cause serious infections. One of the ways to increase a susceptibility of this microorganism to antibiotics is their combining with adjuvant remedies. Objectives. The aim of the research is to study the susceptibility of S. warneri clinical isolate to antibiotics and its modification by emoxypine - 2-ethyl-6-methyl-3-hydroxypyridine hydrochloride. Methods. Samples of purulent wound exudation were obtained from a patient with infective complications after a bone fracture and osteosynthesis by metal plates. Susceptibility of S. warneri clinical isolate to antibiotics and their combinations with emoxypine (1000 μg/disk) was studied by a standard disc diffusion technique. In the case of microbial resistance, the susceptibility of the investigated isolate to such antibiotic was determined by a serial broth dilutions method without or with emoxypine and evaluated according to the minimum inhibitory concentration (MIC). Results. By the disk diffusion method, S. warneri isolate was susceptible to all tested antibiotics, except chloramphenicol. The growth inhibition zones also were formed around disks containing emoxypine, but the susceptibility of S. warneri to this agent was low. Applying of emoxypine on the disks with antibiotics resulted in the increase of S. warneri growth inhibition in all cases, except using the amikacin, gentamicin, and fusidic acid. The most significant changes were evidenced for a composition chloramphenicol / emoxypine. Using chloramphenicol alone in the liquid medium, the MIC was over a cut-off point. Adding of emoxypine (209 μg/ml) decreased the MIC of the antibiotic and restored the susceptibility S. warneri to chloramphenicol. Conclusions. The susceptibility of S. warneri clinical isolate to antibiotics can be increased by combining with emoxypine, which among other overcomes the resistance of the studied microorganism to chloramphenicol.
{"title":"STAPHYLOCOCCUS WARNERI CLINICAL ISOLATE SUSCEPTIBILITY TO ANTIBIOTICS AND ITS MODIFICATION BY EMOXYPINE","authors":"N. Bobrova, E. Vazhnichaya, G. Loban', M. Faustova, M. Ananieva","doi":"10.11603/ijmmr.2413-6077.2020.1.10893","DOIUrl":"https://doi.org/10.11603/ijmmr.2413-6077.2020.1.10893","url":null,"abstract":"Background. S. warneri is a common commensal organism, but it can cause serious infections. One of the ways to increase a susceptibility of this microorganism to antibiotics is their combining with adjuvant remedies. \u0000Objectives. The aim of the research is to study the susceptibility of S. warneri clinical isolate to antibiotics and its modification by emoxypine - 2-ethyl-6-methyl-3-hydroxypyridine hydrochloride. \u0000Methods. Samples of purulent wound exudation were obtained from a patient with infective complications after a bone fracture and osteosynthesis by metal plates. Susceptibility of S. warneri clinical isolate to antibiotics and their combinations with emoxypine (1000 μg/disk) was studied by a standard disc diffusion technique. In the case of microbial resistance, the susceptibility of the investigated isolate to such antibiotic was determined by a serial broth dilutions method without or with emoxypine and evaluated according to the minimum inhibitory concentration (MIC). \u0000Results. By the disk diffusion method, S. warneri isolate was susceptible to all tested antibiotics, except chloramphenicol. The growth inhibition zones also were formed around disks containing emoxypine, but the susceptibility of S. warneri to this agent was low. Applying of emoxypine on the disks with antibiotics resulted in the increase of S. warneri growth inhibition in all cases, except using the amikacin, gentamicin, and fusidic acid. The most significant changes were evidenced for a composition chloramphenicol / emoxypine. Using chloramphenicol alone in the liquid medium, the MIC was over a cut-off point. Adding of emoxypine (209 μg/ml) decreased the MIC of the antibiotic and restored the susceptibility S. warneri to chloramphenicol. \u0000Conclusions. The susceptibility of S. warneri clinical isolate to antibiotics can be increased by combining with emoxypine, which among other overcomes the resistance of the studied microorganism to chloramphenicol.","PeriodicalId":14059,"journal":{"name":"International Journal of Medicine and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64620298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-09DOI: 10.11603/ijmmr.2413-6077.2020.1.11014
A. Bawa-Allah, M. Mashao, T. Nyundu, E. Phukubje, B. G. Nkosi, M. V. Ngema, B. Mlambo, M. Maseko
Background. A non-dipping blood pressure profile (NDP) is associated with increased arterial stiffness and other cardiovascular target organ damage. Serum lipid profiles have been shown to be important determinants of arterial stiffness. Objective. The aim of the research was to assess serum lipid profiles and arterial stiffness in non-dippers. Methods. This cross-sectional study was conducted involving 796 (288 males and 508 females) participants of black African origin. A twenty-four-hour ambulatory BP monitoring was done using a Spacelabs 90207 (Spacelabs Inc., Redmond, Washington, USA) monitor. Carotid-Femoral pulse wave velocity measurements were performed using a high fidelity SPC-301 micromanometer (Millar instruments Inc., Houston, TX). Results. Of the 288 males, 140 were classified as non-dippers. Of the 508 females, 273 were classified as non-dippers. In the general population, males had higher triglycerides when compared with females 1.46±0.96 vs 1.13±1.02, p<0.0001. Additionally, dipper males had higher serum TRGL when compared with dipper females 1.32±0.98 vs 1.06±0.58, p = 0.0012. Non-dipper males also had higher serum TRGL when compared with nondipper females 1.61±2.05 vs 1.19±1.14, p=0.0078. Serum HDLc was lower in the non-dipper male group when compared to the non-dipper female group (p=0.008). In both male and female groups, non-dippers had higher CFPWV when compared with dippers; 7.53±3.60 vs 5.74±2.47, p<0.0001 and 6.64±2.52 vs 5.98±2.23, p=0.0021 respectively. However, non-dipper males had significantly higher CFPWV when compared with non-dipper females (7.53±3.60 vs 6.64±2.52, p=0.0031). Conclusions. Therapies targeting a reduction of serum triglycerides levels might be beneficial in improving arterial compliance with or without the presence of non-dipping.
背景非下降血压曲线（NDP）与动脉硬度增加和其他心血管靶器官损伤有关。血脂谱已被证明是动脉硬化的重要决定因素。客观的这项研究的目的是评估非铲斗患者的血脂状况和动脉硬化。方法。这项横断面研究涉及796名非洲黑人参与者（288名男性和508名女性）。使用Spacelabs 90207（Spacelabs股份有限公司，Redmond，Washington，USA）监测仪进行24小时动态BP监测。使用高保真度SPC-301微压计（Millar instruments股份有限公司，Houston，TX）进行颈动脉-脉搏波速度测量。后果288名男性中，140人被归类为非铲斗类。在508名女性中，273名被归类为非铲斗类。在普通人群中，与女性相比，男性甘油三酯较高，分别为1.46±0.96和1.13±1.02，p＜0.0001。此外，与杓鹬雌蛛相比，杓鹬雄蛛的血清TRGL更高，分别为1.32±0.98和1.06±0.58，p=0.0012。与非糖尿病女性相比，非糖尿病男性的血清TRGL也较高，分别为1.61±2.05和1.19±1.14，p=0.0078。与非铲斗型女性组相比，非铲斗型男性组的血清HDLc较低（p=0.008）。在男性和女性组中，与铲斗型相比，非斗型男性组具有较高的CFPWV；7.53±3.60 vs 5.74±2.47，p<0.0001；6.64±2.52 vs 5.98±2.23，p=0.0021。然而，与非铲斗型女性相比，非铲斗型男性的CFPWV显著更高（7.53±3.60 vs 6.64±2.52，p=0.0031）。结论。针对降低血清甘油三酯水平的治疗可能有利于改善动脉顺应性，无论是否存在非浸渍。
{"title":"SERUM LIPID PROFILE AND ARTERIAL STIFFNESS IN NON-DIPPERS","authors":"A. Bawa-Allah, M. Mashao, T. Nyundu, E. Phukubje, B. G. Nkosi, M. V. Ngema, B. Mlambo, M. Maseko","doi":"10.11603/ijmmr.2413-6077.2020.1.11014","DOIUrl":"https://doi.org/10.11603/ijmmr.2413-6077.2020.1.11014","url":null,"abstract":"Background. A non-dipping blood pressure profile (NDP) is associated with increased arterial stiffness and other cardiovascular target organ damage. Serum lipid profiles have been shown to be important determinants of arterial stiffness. Objective. The aim of the research was to assess serum lipid profiles and arterial stiffness in non-dippers. Methods. This cross-sectional study was conducted involving 796 (288 males and 508 females) participants of black African origin. A twenty-four-hour ambulatory BP monitoring was done using a Spacelabs 90207 (Spacelabs Inc., Redmond, Washington, USA) monitor. Carotid-Femoral pulse wave velocity measurements were performed using a high fidelity SPC-301 micromanometer (Millar instruments Inc., Houston, TX). Results. Of the 288 males, 140 were classified as non-dippers. Of the 508 females, 273 were classified as non-dippers. In the general population, males had higher triglycerides when compared with females 1.46±0.96 vs 1.13±1.02, p<0.0001. Additionally, dipper males had higher serum TRGL when compared with dipper females 1.32±0.98 vs 1.06±0.58, p = 0.0012. Non-dipper males also had higher serum TRGL when compared with nondipper females 1.61±2.05 vs 1.19±1.14, p=0.0078. Serum HDLc was lower in the non-dipper male group when compared to the non-dipper female group (p=0.008). In both male and female groups, non-dippers had higher CFPWV when compared with dippers; 7.53±3.60 vs 5.74±2.47, p<0.0001 and 6.64±2.52 vs 5.98±2.23, p=0.0021 respectively. However, non-dipper males had significantly higher CFPWV when compared with non-dipper females (7.53±3.60 vs 6.64±2.52, p=0.0031). Conclusions. Therapies targeting a reduction of serum triglycerides levels might be beneficial in improving arterial compliance with or without the presence of non-dipping.","PeriodicalId":14059,"journal":{"name":"International Journal of Medicine and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45626519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-27DOI: 10.11603/ijmmr.2413-6077.2019.2.10900
N. Golovenko, T. A. Kabanova, S. Andronati, O. I. Halimova, V. Larionov, A. Reder
Background. Propoxazepam, 7-bromo-5-(2-chlorophenyl)-3-propoxy-1H-benzo[e][1,4]diazepin-2(3H)-one, is a promising analgesic and anticonvulsant and is on preclinical trial. Objective. The aim of the research was to study the anti-inflammatory and analgesic action of Propoxazepam. Methods. The anti-inflammatory action was evaluated by carrageenan induced rat paw edema, formalininduced paw licking response in mice and bradykinin-induced pain response in rat models. Results. It was established for the first time that the administration of Propoxazepam caused a significant anti-inflammatory activity when tested in different in vivo chemical experimental models of induced inflammation, i.e. carrageenan-, bradykininand formalin-induced inflammation tests. Conclusions. Propoxazepam significantly reduced acute and sub-acute inflammation and proved its efficacy and similar to anti-inflammatory action.
{"title":"ANTI-INFLAMMATORY EFFECTS OF PROPOXAZEPAM ON DIFFERENT MODELS OF INFLAMMATION","authors":"N. Golovenko, T. A. Kabanova, S. Andronati, O. I. Halimova, V. Larionov, A. Reder","doi":"10.11603/ijmmr.2413-6077.2019.2.10900","DOIUrl":"https://doi.org/10.11603/ijmmr.2413-6077.2019.2.10900","url":null,"abstract":"Background. Propoxazepam, 7-bromo-5-(2-chlorophenyl)-3-propoxy-1H-benzo[e][1,4]diazepin-2(3H)-one, is a promising analgesic and anticonvulsant and is on preclinical trial. Objective. The aim of the research was to study the anti-inflammatory and analgesic action of Propoxazepam. Methods. The anti-inflammatory action was evaluated by carrageenan induced rat paw edema, formalininduced paw licking response in mice and bradykinin-induced pain response in rat models. Results. It was established for the first time that the administration of Propoxazepam caused a significant anti-inflammatory activity when tested in different in vivo chemical experimental models of induced inflammation, i.e. carrageenan-, bradykininand formalin-induced inflammation tests. Conclusions. Propoxazepam significantly reduced acute and sub-acute inflammation and proved its efficacy and similar to anti-inflammatory action.","PeriodicalId":14059,"journal":{"name":"International Journal of Medicine and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48350401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-27DOI: 10.11603/ijmmr.2413-6077.2019.2.10901
O. Shevchuk, G. Portnichenko, T. Lapikova-Bryginska, S. Goncharov, Nikolaev Vg, V. Dosenko
*O.O. Shevchuk1, G.V. Portnichenko2, T.Y. Lapikova-Bryginska2, S.V. Goncharov2, V.G. Nikolaev3, V.E. Dosenko2 1 – I. HORBACHEVSKY TERNOPIL NATIONAL MEDICAL UNIVERSITY, TERNOPIL, UKRAINE. 2 – O.O. BOGOMOLETZ INSTITUTE OF PHYSIOLOGY OF THE NATIONAL ACADEMY OF SCIENCE OF UKRAINE, KYIV, UKRAINE. 3 – R.E. KAVETSKY INSTITUTE OF EXPERIMENTAL PATHOLOGY, ONCOLOGY AND RADIOBIOLOGY OF THE NATIONAL ACADEMY OF SCIENCE OF UKRAINE, KYIV, UKRAINE.
{"title":"POSITIVE EFFECT OF ENTEROSORPTION IN DOXORUBICIN-INDUCED CARDIOHEMODYNAMICS ALTERATION","authors":"O. Shevchuk, G. Portnichenko, T. Lapikova-Bryginska, S. Goncharov, Nikolaev Vg, V. Dosenko","doi":"10.11603/ijmmr.2413-6077.2019.2.10901","DOIUrl":"https://doi.org/10.11603/ijmmr.2413-6077.2019.2.10901","url":null,"abstract":"*O.O. Shevchuk1, G.V. Portnichenko2, T.Y. Lapikova-Bryginska2, S.V. Goncharov2, V.G. Nikolaev3, V.E. Dosenko2 1 – I. HORBACHEVSKY TERNOPIL NATIONAL MEDICAL UNIVERSITY, TERNOPIL, UKRAINE. 2 – O.O. BOGOMOLETZ INSTITUTE OF PHYSIOLOGY OF THE NATIONAL ACADEMY OF SCIENCE OF UKRAINE, KYIV, UKRAINE. 3 – R.E. KAVETSKY INSTITUTE OF EXPERIMENTAL PATHOLOGY, ONCOLOGY AND RADIOBIOLOGY OF THE NATIONAL ACADEMY OF SCIENCE OF UKRAINE, KYIV, UKRAINE.","PeriodicalId":14059,"journal":{"name":"International Journal of Medicine and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46072053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-27DOI: 10.11603/ijmmr.2413-6077.2019.2.10902
H. Bezkorovaina, I. Klishch, M. Khara, V. Pelykh
Background. Cardiovascular disease is the main cause of morbidity predominantly in males. Stress is one of the crucial factors, especially with light desynchronosis. Objective of the study was to assess gender-specific characteristics of cardiac vegetative control in myocardial necrosis in cases of light deprivation. Methods. Cardiac vegetative control in adrenaline-induced myocardial necrosis (AIMN) in a setting of light deprivation (LD) was assessed in 72 mature white rats of both sexes. The animals were divided into 2 groups: G1 – the animals kept under day/night cyclic balance (12 hours/12 hours); G2 – the animals kept at LD (illumination 0.5-1 LX) for 10 days. On Day 11, AIMN caused by adrenaline (0.5 mg/kg) and heart rate variability (HRV) was assessed in 1 hour and 24 hours. Results. The development of AIMN at LD in the ♂G2 led to HRV increase that was caused by augmentation of parasympathetic and reduction of sympathetic cardiac effects. In cases of AIMN, changes of CVC in the ♀G2 were similar to the ♀G1. However, in 1 hour of AIMN, parasympathetic cardiac effects were more significant than in the ♀G1. While the ♀G2 AIMN animals experienced balanced sympathetic and parasympathetic actions, the predominance of the sympathetic component was evidenced in the ♀G1 AIMN animals. Conclusions. Light deprivation has different effects on baseline sympathetic/parasympathetic balance in males and females, i.e. increased parasympathetic control of heart rhythm in males and maintenance of sympathetic/ parasympathetic balance in females.
{"title":"GENDER-SPECIFIC DIFFERENCES OF CARDIAC VEGETATIVE CONTROL IN ADRENALINE-INDUCED NECROSIS AND LIGHT DEPRIVATION","authors":"H. Bezkorovaina, I. Klishch, M. Khara, V. Pelykh","doi":"10.11603/ijmmr.2413-6077.2019.2.10902","DOIUrl":"https://doi.org/10.11603/ijmmr.2413-6077.2019.2.10902","url":null,"abstract":"Background. Cardiovascular disease is the main cause of morbidity predominantly in males. Stress is one of the crucial factors, especially with light desynchronosis. Objective of the study was to assess gender-specific characteristics of cardiac vegetative control in myocardial necrosis in cases of light deprivation. Methods. Cardiac vegetative control in adrenaline-induced myocardial necrosis (AIMN) in a setting of light deprivation (LD) was assessed in 72 mature white rats of both sexes. The animals were divided into 2 groups: G1 – the animals kept under day/night cyclic balance (12 hours/12 hours); G2 – the animals kept at LD (illumination 0.5-1 LX) for 10 days. On Day 11, AIMN caused by adrenaline (0.5 mg/kg) and heart rate variability (HRV) was assessed in 1 hour and 24 hours. Results. The development of AIMN at LD in the ♂G2 led to HRV increase that was caused by augmentation of parasympathetic and reduction of sympathetic cardiac effects. In cases of AIMN, changes of CVC in the ♀G2 were similar to the ♀G1. However, in 1 hour of AIMN, parasympathetic cardiac effects were more significant than in the ♀G1. While the ♀G2 AIMN animals experienced balanced sympathetic and parasympathetic actions, the predominance of the sympathetic component was evidenced in the ♀G1 AIMN animals. Conclusions. Light deprivation has different effects on baseline sympathetic/parasympathetic balance in males and females, i.e. increased parasympathetic control of heart rhythm in males and maintenance of sympathetic/ parasympathetic balance in females.","PeriodicalId":14059,"journal":{"name":"International Journal of Medicine and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45927866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-26DOI: 10.11603/ijmmr.2413-6077.2019.2.10895
Yuriy Mysula
Background. Bipolar affective disorder (BAD) is a topical issue of contemporary psychiatry. The features of the primary episode (PE) of the disease are extremely important for prognosis, treatment and rehabilitation measures of BAD. Individual psychological features of the patients with PE of BAD are still unexplored that complicates development of new methods of prediction, treatment and prevention of BAD. Objective. The aim of the study was to investigate individual psychological features of the patients with a primary episode of bipolar affective disorder, taking into account the gender factor and clinical variant of the BAD debut. Methods. 153 patients (65 men and 88 women) with a primary episode of bipolar affective disorder were examined. The patients were divided into three groups according to the clinical variant of the course of PE of BAD: depressive variant, manic variant and mixed variant. The examination was carried out using the Standardized multifactor method of personality research (SMMPR). Statistical processing of the data was performed using the non-parametric Mann-Whitney test. Results. The most significant differences in the quantitative indicators of SMMPR were found when comparing depressive and manic, as well as depressive and mixed variants of PE of BAD, and lesser – when comparing manic and mixed variants. Most of all, these differences were expressed in terms of pessimism, impulsiveness, individualism and optimism. Conclusions. Some peculiar features of male and female patients with depressive, manic and mixed variants of PE of BAD promoting to search for new methods of prediction, treatment and prevention of BAD have been defined.
{"title":"PRIMARY EPISODE OF BIPOLAR AFFECTIVE DISORDER","authors":"Yuriy Mysula","doi":"10.11603/ijmmr.2413-6077.2019.2.10895","DOIUrl":"https://doi.org/10.11603/ijmmr.2413-6077.2019.2.10895","url":null,"abstract":"Background. Bipolar affective disorder (BAD) is a topical issue of contemporary psychiatry. The features of the primary episode (PE) of the disease are extremely important for prognosis, treatment and rehabilitation measures of BAD. Individual psychological features of the patients with PE of BAD are still unexplored that complicates development of new methods of prediction, treatment and prevention of BAD. Objective. The aim of the study was to investigate individual psychological features of the patients with a primary episode of bipolar affective disorder, taking into account the gender factor and clinical variant of the BAD debut. Methods. 153 patients (65 men and 88 women) with a primary episode of bipolar affective disorder were examined. The patients were divided into three groups according to the clinical variant of the course of PE of BAD: depressive variant, manic variant and mixed variant. The examination was carried out using the Standardized multifactor method of personality research (SMMPR). Statistical processing of the data was performed using the non-parametric Mann-Whitney test. Results. The most significant differences in the quantitative indicators of SMMPR were found when comparing depressive and manic, as well as depressive and mixed variants of PE of BAD, and lesser – when comparing manic and mixed variants. Most of all, these differences were expressed in terms of pessimism, impulsiveness, individualism and optimism. Conclusions. Some peculiar features of male and female patients with depressive, manic and mixed variants of PE of BAD promoting to search for new methods of prediction, treatment and prevention of BAD have been defined.","PeriodicalId":14059,"journal":{"name":"International Journal of Medicine and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41501008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-26DOI: 10.11603/ijmmr.2413-6077.2019.2.10896
L. Logoyda
Background. Robustness tests were firstly introduced for avoiding problems in interlaboratory studies and identifying the factors potentially responsible. A robustness test performing in late validation procedure involves the possibility that when the method is established not robust, it should be redeveloped and optimized. At this stage much effort has been made and money spent for optimization and validation, and therefore avoiding this would be great. Objective. The aim of the study was to consider the robustness of HPLC determination of enalapril (in tablets) by the Youden’s test. Methods. Youden’s test was chosen as an efficient method to assess the robustness among all analytical methods that is by means of an experiment design, which involved seven analytical parameters combined in eight tests. In previous studies, we evaluated the chromatographic method robustness to quantify enalapril (in tablets) by Youden’s test. Results. According to the Youden’s test criteria, HPLC method proved to be greatly robust regarding the enalapril content in introduction of variation of seven analytic parameters. The lowest variation in enalapril content was 0.91 %, when Grace Platinumр C8 EPS column (4.6 mm i.d. X 250 mm, 5 μm) was used. A holistic approach concerning simultaneous innovations in particle technology and instrument design was endeavored for the first time to meet and tackle the analytical laboratory issues. This was aimed at promoting success of analytical scientists as well as profitability and productiveness of business. Conclusion. The Youden’s test has been proved to be an efficient and useful tool for evaluation of robustness of enalapril HPLC assay. KEY WORD: enalapril; high-performance liquid chromatography; robustness; quantitative analysis; Youden’s test.
{"title":"YOUDEN'S TEST FOR CHROMATOGRAPHIC DETERMINATION OF ENALAPRIL IN PHARMACEUTICALS","authors":"L. Logoyda","doi":"10.11603/ijmmr.2413-6077.2019.2.10896","DOIUrl":"https://doi.org/10.11603/ijmmr.2413-6077.2019.2.10896","url":null,"abstract":"Background. Robustness tests were firstly introduced for avoiding problems in interlaboratory studies and identifying the factors potentially responsible. A robustness test performing in late validation procedure involves the possibility that when the method is established not robust, it should be redeveloped and optimized. At this stage much effort has been made and money spent for optimization and validation, and therefore avoiding this would be great. Objective. The aim of the study was to consider the robustness of HPLC determination of enalapril (in tablets) by the Youden’s test. Methods. Youden’s test was chosen as an efficient method to assess the robustness among all analytical methods that is by means of an experiment design, which involved seven analytical parameters combined in eight tests. In previous studies, we evaluated the chromatographic method robustness to quantify enalapril (in tablets) by Youden’s test. Results. According to the Youden’s test criteria, HPLC method proved to be greatly robust regarding the enalapril content in introduction of variation of seven analytic parameters. The lowest variation in enalapril content was 0.91 %, when Grace Platinumр C8 EPS column (4.6 mm i.d. X 250 mm, 5 μm) was used. A holistic approach concerning simultaneous innovations in particle technology and instrument design was endeavored for the first time to meet and tackle the analytical laboratory issues. This was aimed at promoting success of analytical scientists as well as profitability and productiveness of business. Conclusion. The Youden’s test has been proved to be an efficient and useful tool for evaluation of robustness of enalapril HPLC assay. KEY WORD: enalapril; high-performance liquid chromatography; robustness; quantitative analysis; Youden’s test.","PeriodicalId":14059,"journal":{"name":"International Journal of Medicine and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44594811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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