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State Feedback Control for Vehicle Electro-Hydraulic Braking Systems Based on Adaptive Genetic Algorithm Optimization 基于自适应遗传算法优化的车辆电液制动系统状态反馈控制
IF 7 2区 计算机科学 Q1 Mathematics Pub Date : 2024-03-27 DOI: 10.1155/2024/3616505
Jinhua Zhang, Lifeng Ding, Shangbin Long

In traditional state feedback control, the difficulty in determining the coefficient matrix is a significant factor that prevents achieving optimal control. To address this issue, this paper proposes the integration of adaptive genetic algorithms with state feedback control. The effectiveness of the proposed algorithm is validated via an electro-hydraulic braking system. Firstly, a model of the electro-hydraulic braking system is introduced. Next, a state feedback controller optimized by parameter-adaptive genetic algorithm is designed. Additionally, a penalty term is introduced into the fitness function to suppress overshoots. Finally, simulations are conducted to compare the convergence speed of parameter-adaptive genetic algorithm with genetic algorithm, ant colony optimization, and particle swarm optimization. Furthermore, the performance of the proposed algorithm, the state feedback control, and the proportional-integral control are also compared. The comparison results show that the proposed algorithm effectively accelerates the settling time of the electro-hydraulic braking system and suppresses the overshoots.

在传统的状态反馈控制中,难以确定系数矩阵是阻碍实现最优控制的一个重要因素。为解决这一问题,本文提出将自适应遗传算法与状态反馈控制相结合。本文通过一个电液制动系统验证了所提算法的有效性。首先,介绍了电液制动系统的模型。接着,设计了一个通过参数自适应遗传算法优化的状态反馈控制器。此外,在拟合函数中引入了惩罚项,以抑制超调。最后,通过仿真比较了参数自适应遗传算法与遗传算法、蚁群优化和粒子群优化的收敛速度。此外,还比较了拟议算法、状态反馈控制和比例积分控制的性能。比较结果表明,提出的算法有效地加快了电液制动系统的平稳时间,并抑制了过冲。
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引用次数: 0
Artificial Intelligence in 6G Wireless Networks: Opportunities, Applications, and Challenges 6G 无线网络中的人工智能:机遇、应用和挑战
IF 7 2区 计算机科学 Q1 Mathematics Pub Date : 2024-03-25 DOI: 10.1155/2024/8845070
Abdulraqeb Alhammadi, Ibraheem Shayea, Ayman A. El-Saleh, Marwan Hadri Azmi, Zool Hilmi Ismail, Lida Kouhalvandi, Sawan Ali Saad

Wireless technologies are growing unprecedentedly with the advent and increasing popularity of wireless services worldwide. With the advancement in technology, profound techniques can potentially improve the performance of wireless networks. Besides, the advancement of artificial intelligence (AI) enables systems to make intelligent decisions, automation, data analysis, insights, predictive capabilities, learning, and adaptation. A sophisticated AI will be required for next-generation wireless networks to automate information delivery between smart applications simultaneously. AI technologies, such as machines and deep learning techniques, have attained tremendous success in many applications in recent years. Hances, researchers in academia and industry have turned their attention to the advanced development of AI-enabled wireless networks. This paper comprehensively surveys AI technologies for different wireless networks with various applications. Moreover, we present various AI-enabled applications that exploit the power of AI to enable the desired evolution of wireless networks. Besides, the challenges of unsolved research in this area, which represent the future research trends of AI-enabled wireless networks, are discussed in detail. We provide several suggestions and solutions that help wireless networks be more intelligent and sophisticated to handle complicated problems. In summary, this paper can help researchers deeply understand the up-to-the-minute wireless network designs based on AI technologies and identify interesting unsolved issues to be pursued in their research in a fast way.

随着全球无线服务的出现和日益普及,无线技术正以前所未有的速度发展。随着技术的进步,高深的技术有可能提高无线网络的性能。此外,人工智能(AI)的发展使系统能够进行智能决策、自动化、数据分析、洞察力、预测能力、学习和适应。下一代无线网络需要复杂的人工智能,以便同时在智能应用之间自动传递信息。近年来,机器和深度学习技术等人工智能技术在许多应用领域取得了巨大成功。因此,学术界和工业界的研究人员已将注意力转向人工智能无线网络的先进发展。本文全面探讨了人工智能技术在不同无线网络中的各种应用。此外,我们还介绍了各种人工智能应用,这些应用利用人工智能的力量实现了无线网络的理想演进。此外,我们还详细讨论了该领域尚未解决的研究挑战,这些挑战代表了人工智能无线网络的未来研究趋势。我们还提供了一些建议和解决方案,帮助无线网络更加智能和精密地处理复杂问题。总之,本文可以帮助研究人员深入了解基于人工智能技术的最新无线网络设计,并在研究中快速发现有趣的未决问题。
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引用次数: 0
An Adaptive Combined Learning of Grading System for Early Stage Emerging Diseases 针对早期新发疾病的自适应分级组合学习系统
IF 7 2区 计算机科学 Q1 Mathematics Pub Date : 2024-03-23 DOI: 10.1155/2024/6619263
Li Wen, Wei Pan, Yongdong Shi, Wulin Pan, Cheng Hu, Wenxuan Kong, Renjie Wang, Wei Zhang, Shujie Liao

Currently, individual artificial intelligence (AI) algorithms face significant challenges in effectively diagnosing and predicting early stage emerging serious diseases. Our investigation indicates that these challenges primarily arise from insufficient clinical treatment data, leading to inadequate model training and substantial disparities among algorithm outcomes. Therefore, this study introduces an adaptive framework aimed at increasing prediction accuracy and mitigating instability by integrating various AI algorithms. In analyzing two cohorts of early cases of the coronavirus disease 2019 (COVID-19) in Wuhan, China, we demonstrate the reliability and precision of the adaptive combined learning algorithm. Employing an adaptive combination with three feature importance methods (Random Forest (RF), Scalable end-to-end Tree Boosting System (XGBoost), and Sparsity Oriented Importance Learning (SOIL)) for two cohorts, we identified 23 clinical features with significant impacts on COVID-19 outcomes. Subsequently, the adaptive combined prediction leveraged and enhanced the advantages of individual methods based on three forecasting algorithms (RF, XGBoost, and Logistic regression). The average accuracy for both cohorts exceeded 0.95, with the area under the receiver operating characteristics curve (AUC) values of 0.983 and 0.988, respectively. We established a severity grading system for COVID-19 based on the combined probability of death. Compared to the original classification, there was a significant decrease in the number of patients in the severe and critical levels, while the levels of mild and moderate showed a substantial increase. This severity grading system provides a more rational grading in clinical treatment. Clinicians can utilize this system for effective and reliable preliminary assessments and examinations of patients with emerging diseases, enabling timely and targeted treatment.

目前,单个人工智能(AI)算法在有效诊断和预测早期新出现的严重疾病方面面临巨大挑战。我们的调查表明,这些挑战主要源于临床治疗数据不足,导致模型训练不足和算法结果之间的巨大差异。因此,本研究引入了一个自适应框架,旨在通过整合各种人工智能算法来提高预测准确性并降低不稳定性。通过分析中国武汉两组2019年冠状病毒病(COVID-19)早期病例,我们证明了自适应组合学习算法的可靠性和精确性。我们在两个队列中采用了自适应组合与三种特征重要性方法(随机森林(Random Forest,RF)、可扩展端到端树提升系统(Scalable end-to-end Tree Boosting System,XGBoost)和稀疏性导向重要性学习(Sparsity Oriented Importance Learning,SOIL)),识别出了对COVID-19结果有显著影响的23个临床特征。随后,基于三种预测算法(RF、XGBoost 和逻辑回归)的自适应组合预测利用并增强了单个方法的优势。两个队列的平均准确率都超过了 0.95,接收者操作特征曲线下面积(AUC)值分别为 0.983 和 0.988。我们根据综合死亡概率为 COVID-19 建立了严重程度分级系统。与原来的分级相比,重度和危重患者人数明显减少,而轻度和中度患者人数则大幅增加。这种严重程度分级系统为临床治疗提供了更合理的分级。临床医生可利用该系统对新发疾病患者进行有效、可靠的初步评估和检查,以便及时进行有针对性的治疗。
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引用次数: 0
An Efficient Secure Sharing of Electronic Health Records Using IoT-Based Hyperledger Blockchain 利用基于物联网的超级账本区块链高效安全地共享电子健康记录
IF 7 2区 计算机科学 Q1 Mathematics Pub Date : 2024-03-22 DOI: 10.1155/2024/6995202
Velmurugan S., Prakash M., Neelakandan S., Eric Ofori Martinson

Electronic Health Record (EHR) systems are a valuable and effective tool for exchanging medical information about patients between hospitals and other significant healthcare sector stakeholders in order to improve patient diagnosis and treatment around the world. Nevertheless, the majority of the hospital infrastructures that are now in place lack the proper security, trusted access control, and management of privacy and confidentiality concerns that the current EHR systems are supposed to provide. Goal. For various EHR systems, this research proposes a Blockchain-enabled Hyperledger Fabric Architecture as a solution to this delicate issue. The three steps of the suggested system are the secure upload phase, the secure download phase, and authentication. Patient registration, login, and verification make up the authentication step. The administrator grants authorization to read, edit, delete, or revoke the files following user details verification. In the secure upload phase, feature extraction is carried out first, and then a hashed access policy is created from the extracted feature. Next, the hash value is stored in an IoT-based Hyperledger blockchain. The uploaded EHR files are additionally encrypted before being stored on the cloud server. In the secure download step, the physician uses a hashed access policy to send the request to the cloud and decrypts the corresponding files. The experimental findings demonstrate that the system outperformed cutting-edge techniques. The proposed Modified Key Policy Attribute-Based Encryption performs better for the remaining 10 to 25 mb file sizes. This IoT framework compares MKP-ABE with certain efficiency indicators, such as encryption, decryption period, protection level analysis and encrypted memory use, resource use on decryption, upload time, and transfer time, which are present in the KP-ABE, the ECC, RSA, and AES. Here, the IoT device suggested requires 4008 ms for data encryption and 4138 ms for the data decryption.

电子病历(EHR)系统是医院与其他重要的医疗保健部门利益相关者之间交换病人医疗信息的重要而有效的工具,可改善世界各地的病人诊断和治疗。然而,目前大多数医院的基础设施都缺乏适当的安全性、可信的访问控制以及隐私和保密性管理,而这些正是目前的电子病历系统应该提供的。目标。针对各种电子病历系统,本研究提出了一种支持区块链的超级账本架构(Hyperledger Fabric Architecture),作为这一棘手问题的解决方案。建议系统的三个步骤是安全上传阶段、安全下载阶段和身份验证。患者注册、登录和验证构成了身份验证步骤。管理员在验证用户详细信息后,授予读取、编辑、删除或撤销文件的权限。在安全上传阶段,首先进行特征提取,然后根据提取的特征创建哈希访问策略。然后,将哈希值存储在基于物联网的超级账本区块链中。上传的电子病历文件在存储到云服务器之前还要进行加密。在安全下载步骤中,医生使用散列访问策略向云发送请求并解密相应文件。实验结果表明,该系统的性能优于尖端技术。对于剩余的 10 到 25 mb 文件大小,所提出的基于属性的修改密钥策略加密技术表现更好。该物联网框架将 MKP-ABE 与 KP-ABE、ECC、RSA 和 AES 中的某些效率指标进行了比较,如加密、解密周期、保护级别分析和加密内存使用、解密资源使用、上传时间和传输时间。在此,建议物联网设备的数据加密时间为 4008 毫秒,数据解密时间为 4138 毫秒。
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引用次数: 0
Tripartite Evolutionary Game Analysis of a Logistics Service Supply Chain Cooperation Mechanism for Network Freight Platforms 网络货运平台物流服务供应链合作机制的三方进化博弈分析
IF 7 2区 计算机科学 Q1 Mathematics Pub Date : 2024-03-20 DOI: 10.1155/2024/4820877
Guanxiong Wang, Xiaojian Hu, Ting Wang, Jiqiong Liu, Shuai Feng, Chuanlei Wang

The rapid development of network freight platforms has directly increased the level of social logistics resource collaboration and improved both the efficiency and quality of logistics industry services. As a bilateral platform that connects freight shippers and freight carriers, the organizational structure and operational mode of network freight platforms differ substantially from those of traditional logistics service providers. In this paper, a tripartite evolutionary game model is constructed in which a network freight platform, freight shipper, and freight carrier are considered, and the evolutionary stability strategies of the parties and the tripartite system are dynamically analyzed. The reliability of the model is verified through a numerical case, and several countermeasures have been proposed to improve the stability of the system based on the sensitivity analysis of important parameters. This paper helps standardize the principal behavior of all parties under the network freight mode, reduce the default risk of all parties, and improve the overall cooperation stability of the logistics service supply chain.

网络货运平台的快速发展,直接提升了社会物流资源协作水平,提高了物流业服务效率和质量。作为连接货运托运人和货运承运人的双边平台,网络货运平台的组织结构和运营模式与传统物流服务提供商有很大不同。本文构建了一个三方演化博弈模型,考虑了网络货运平台、货运托运人和货运承运人,动态分析了各方和三方系统的演化稳定策略。通过数值案例验证了模型的可靠性,并在重要参数敏感性分析的基础上提出了若干提高系统稳定性的对策。本文有助于规范网络货运模式下各方的主体行为,降低各方的违约风险,提高物流服务供应链的整体合作稳定性。
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引用次数: 0
A Triplet Multimodel Transfer Learning Network for Speech Disorder Screening of Parkinson’s Disease 用于帕金森病语言障碍筛查的三重多模型迁移学习网络
IF 7 2区 计算机科学 Q1 Mathematics Pub Date : 2024-03-20 DOI: 10.1155/2024/8890592
Aite Zhao, Nana Wang, Xuesen Niu, Ming Chen, Huimin Wu

Deterioration in the quality of a person’s voice and speech is an early sign of Parkinson’s disease (PD). Although a number of computer-based methods have been invested to use patients’ speech for early diagnosis of Parkinson’s disease, they only focus on a fixed pronunciation test, such as the subjects’ monosyllabic pronunciation is analyzed to determine whether they have potential possibility of PD. Moreover, only using traditional speech analysis methods to extract single-view speech features cannot provide a comprehensive feature representation. This paper is dedicated to the study of various pronunciation tests for patients with PD, including the pronunciation of five monosyllabic vowels and a spontaneous dialogue. A triplet multimodel transfer learning network is designed and proposed for identifying subjects with PD in these two groups of tests. First, multisource data extract mel frequency cepstrum coefficient (MFCC) features of speech for preprocessing. Subsequently, a pretrained triplet model represents features from three dimensions as the upstream task of the transfer learning framework. Finally, the pretrained model is reconstructed as a novel model that integrates the triplet model, temporal model, and auxiliary layer as the downstream task, and weights are updated through fine-tuning to identify abnormal speech. Experimental results show that the highest PD detection rates in the two groups of tests are 99% and 90% , respectively, which outperform a large number of internationally popular pattern recognition algorithms and serve as a baseline for other academic researchers in this field.

嗓音和语言质量的下降是帕金森病(PD)的早期征兆。虽然目前已有一些基于计算机的方法利用患者的语音来进行帕金森病的早期诊断,但这些方法只关注固定的发音测试,如通过分析受试者的单音节发音来判断其是否有患帕金森病的潜在可能。此外,仅使用传统语音分析方法提取单视角语音特征并不能提供全面的特征表征。本文专门研究了针对帕金森氏症患者的各种发音测试,包括五个单音节元音的发音和一段自发对话。本文设计并提出了一种三元组多模型迁移学习网络,用于在这两组测试中识别患有帕金森病的受试者。首先,多源数据提取语音的熔频倒频谱系数(MFCC)特征进行预处理。然后,作为迁移学习框架的上游任务,预训练的三元组模型从三个维度表示特征。最后,作为下游任务,将预训练模型重构为一个整合了三元组模型、时序模型和辅助层的新模型,并通过微调更新权重来识别异常语音。实验结果表明,在两组测试中,PD 的最高检测率分别为 99% 和 90%,优于大量国际流行的模式识别算法,可作为该领域其他学术研究人员的基准线。
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引用次数: 0
Semisupervised Medical Image Segmentation through Prototype-Based Mutual Consistency Learning 通过基于原型的相互一致性学习进行半监督医学图像分割
IF 7 2区 计算机科学 Q1 Mathematics Pub Date : 2024-03-15 DOI: 10.1155/2024/9928155
Xinqiang Wang, Wenhuan Lu, Si Li, Ke Zheng, Junhai Xu, Jianguo Wei

Medical image segmentation is a critical task in the healthcare field. While deep learning techniques have shown promise in this area, they often require a large number of accurately labeled images. To address this issue, semisupervised learning has emerged as a potential solution by reducing the reliance on precise annotations. Among these approaches, the student-teacher framework has garnered attention, but it is limited in its reliance solely on the teacher model for information. To overcome this limitation, we propose a prototype-based mutual consistency learning (PMCL) framework. This framework utilizes two branches that learn from each other, incorporating supervision loss and consistency loss to adapt to minor data perturbations and structural differences. By employing prototype consistency learning, we are able to achieve reliable consistency loss. Our experiments on three public medical image datasets demonstrate that PMCL outperforms other state-of-the-art methods, indicating its potential in semisupervised medical image segmentation. Our framework has the potential to assist medical professionals in enhancing their diagnoses and delivering improved patient care.

医学图像分割是医疗保健领域的一项关键任务。虽然深度学习技术在这一领域大有可为,但它们往往需要大量精确标注的图像。为了解决这个问题,半监督学习通过减少对精确标注的依赖成为一种潜在的解决方案。在这些方法中,"学生-教师 "框架备受关注,但其局限性在于仅依赖教师模型获取信息。为了克服这一局限性,我们提出了基于原型的相互一致性学习(PMCL)框架。该框架利用两个相互学习的分支,结合监督损失和一致性损失来适应微小的数据扰动和结构差异。通过采用原型一致性学习,我们能够实现可靠的一致性损失。我们在三个公共医疗图像数据集上进行的实验表明,PMCL 的表现优于其他最先进的方法,这表明它在半监督医疗图像分割方面的潜力。我们的框架有望帮助医疗专业人员提高诊断水平,改善病人护理。
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引用次数: 0
Patterns in the Growth and Thematic Evolution of Artificial Intelligence Research: A Study Using Bradford Distribution of Productivity and Path Analysis 人工智能研究的增长和主题演变模式:利用布拉德福德生产力分布和路径分析进行的研究
IF 7 2区 计算机科学 Q1 Mathematics Pub Date : 2024-03-14 DOI: 10.1155/2024/5511224
Solanki Gupta, Anurag Kanaujia, Hiran H. Lathabai, Vivek Kumar Singh, Philipp Mayr

Artificial intelligence (AI) has emerged as a transformative technology with applications across multiple domains. The corpus of work related to the field of AI has grown significantly in volume as well as in terms of the application of AI in wider domains. However, given the wide application of AI in diverse areas, the measurement and characterization of the span of AI research is often a challenging task. Bibliometrics is a well-established method in the scientific community to measure the patterns and impact of research. It however has also received significant criticism for its overemphasis on the macroscopic picture and the inability to provide a deep understanding of growth and thematic structure of knowledge-creation activities. Therefore, this study presents a framework comprising of two techniques, namely, Bradford’s distribution and path analysis to characterize the growth and thematic evolution of the discipline. While the Bradford distribution provides a macroscopic view of artificial intelligence research in terms of patterns of growth, the path analysis method presents a microscopic analysis of the thematic evolutionary trajectories, thereby completing the analytical framework. Detailed insights into the evolution of each subdomain are drawn, major techniques employed in various AI applications are identified, and some relevant implications are discussed to demonstrate the usefulness of the analyses.

人工智能(AI)已成为一种横跨多个领域的变革性技术。与人工智能领域相关的研究成果在数量上以及人工智能在更广泛领域的应用方面都有了显著增长。然而,鉴于人工智能在不同领域的广泛应用,衡量和描述人工智能研究的跨度往往是一项具有挑战性的任务。文献计量学是科学界公认的衡量研究模式和影响的方法。然而,这种方法也受到了不少批评,因为它过于强调宏观图景,无法深入了解知识创造活动的增长和主题结构。因此,本研究提出了一个由布拉德福德分布和路径分析两种技术组成的框架,以描述学科增长和主题演变的特征。布拉德福德分布从宏观上展示了人工智能研究的增长模式,而路径分析方法则从微观上分析了专题演变轨迹,从而完善了分析框架。我们对每个子领域的演变都进行了详细的深入分析,确定了在各种人工智能应用中采用的主要技术,并讨论了一些相关的影响,以证明这些分析的实用性。
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引用次数: 0
Adaptive Threshold Learning in Frequency Domain for Classification of Breast Cancer Histopathological Images 用于乳腺癌组织病理学图像分类的频域自适应阈值学习
IF 7 2区 计算机科学 Q1 Mathematics Pub Date : 2024-03-11 DOI: 10.1155/2024/9199410
Yujian Liu, Xiaozhang Liu, Yuan Qi

Breast cancer has become the most common cancer in the world, and biopsy is the most reliable and widely used technique for detecting breast cancer. However, observation of histopathological images is time-consuming and labor-intensive. Currently, CNN has become the mainstream method for breast cancer histopathological image classification research. However, some studies have found that the optical microscope-generated histopathological images have noise, and the output of a well-trained convolutional neural network in image classification tasks can change drastically due to small variations in the input. Therefore, the quality of the image significantly affects the accuracy of the classification. Wavelet transform is a commonly used denoising method, but the selection of the threshold is a difficult problem, and traditional methods are difficult to find the appropriate threshold quickly and accurately. This paper proposes an adaptive threshold selection method that combines threshold selection steps with deep learning methods by using the threshold as a parameter in the CNN model to train. In this way, we associate the threshold with the classification result of the model and find the appropriate value for that image and task by back-propagation in training. The method was experimented on publicly available datasets BreaKHis and BACH. The results in BreaKHis (40x: 94.37%, 100x: 93.85%, 200x: 91.63%, 400x: 93.31%), and BACH (91.25%) demonstrate that our adaptive threshold selection method can improve classification accuracy and is significantly superior to traditional threshold selection methods.

乳腺癌已成为世界上最常见的癌症,而活检是检测乳腺癌最可靠和最广泛使用的技术。然而,观察组织病理图像耗时耗力。目前,CNN 已成为乳腺癌组织病理图像分类研究的主流方法。然而,一些研究发现,光学显微镜生成的组织病理图像存在噪声,在图像分类任务中,训练有素的卷积神经网络的输出会因输入的微小变化而发生剧烈变化。因此,图像质量会极大地影响分类的准确性。小波变换是一种常用的去噪方法,但阈值的选择是一个难题,传统方法很难快速准确地找到合适的阈值。本文提出了一种自适应阈值选择方法,将阈值选择步骤与深度学习方法相结合,将阈值作为 CNN 模型中的一个参数进行训练。这样,我们将阈值与模型的分类结果关联起来,并在训练中通过反向传播找到适合该图像和任务的值。该方法在公开数据集 BreaKHis 和 BACH 上进行了实验。在 BreaKHis(40x:94.37%;100x:93.85%;200x:91.63%;400x:93.31%)和 BACH(91.25%)中的结果表明,我们的自适应阈值选择方法可以提高分类准确率,并且明显优于传统的阈值选择方法。
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引用次数: 0
Attention-Based Learning for Predicting Drug-Drug Interactions in Knowledge Graph Embedding Based on Multisource Fusion Information 基于多源融合信息的知识图谱嵌入中预测药物相互作用的注意力学习法
IF 7 2区 计算机科学 Q1 Mathematics Pub Date : 2024-03-02 DOI: 10.1155/2024/5155997
Yu Li, Zhu-Hong You, Shu-Min Wang, Cheng-Gang Mi, Mei-Neng Wang, Yu-An Huang, Hai-Cheng Yi

Drug combinations can reduce drug resistance and side effects and enable the improvement of disease treatment efficacy. Therefore, how to effectively identify drug-drug interactions (DDIs) is a challenging problem. Currently, there exist several approaches that leverage advanced representation learning and graph-based techniques for DDIs prediction. While these methods have demonstrated promising results, a limited number of approaches effectively utilize the potential of knowledge graphs (KGs), which provide information on drug attributes and multirelation among entities. In this work, we introduce a novel attention-based KGs representation learning framework. To encode drug SMILES sequence, a pretrained model is used, while molecular structure information is mapped as the initialization of nodes within the KG using a message-passing neural network. Additionally, the knowledge-aware graph attention network is employed to capture the drug and its topological neighbor representation in the KG representation module. To prevent the oversmoothing problem, the residual layer is used in the DDI prediction module. Comprehensive experiments on several datasets have demonstrated that the proposed method outperforms the state-of-the-art algorithms on the DDI prediction task across a range of evaluation metrics. It achieves an accuracy of 0.924 and an AUC of 0.9705 on the KEGG dataset and attains an ACC of 0.9777 and an AUC of 0.9959 on the OGB-biokg dataset. These experimental findings affirm that our approach is a dependable model for predicting the association of drugs.

联合用药可以减少耐药性和副作用,提高疾病治疗效果。因此,如何有效识别药物间相互作用(DDIs)是一个具有挑战性的问题。目前,有几种方法利用先进的表示学习和基于图的技术进行 DDIs 预测。虽然这些方法都取得了可喜的成果,但有效利用知识图谱(KG)潜力的方法为数不多,而知识图谱可提供药物属性和实体间多重关系的信息。在这项工作中,我们介绍了一种新颖的基于注意力的知识图谱表示学习框架。为了对药物 SMILES 序列进行编码,我们使用了一个预训练模型,同时使用消息传递神经网络将分子结构信息映射为知识图谱中节点的初始化。此外,知识感知图注意网络用于捕捉 KG 表示模块中的药物及其拓扑邻域表示。为了防止过平滑问题,DDI 预测模块中使用了残差层。在多个数据集上进行的综合实验表明,在 DDI 预测任务上,所提出的方法在一系列评价指标上都优于最先进的算法。在 KEGG 数据集上,该方法的准确率达到 0.924,AUC 达到 0.9705;在 OGB-biokg 数据集上,该方法的 ACC 达到 0.9777,AUC 达到 0.9959。这些实验结果证明,我们的方法是预测药物关联的可靠模型。
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International Journal of Intelligent Systems
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