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Three-dimensional ultrasound fusion imaging in precise needle placement for thermal ablation of hepatocellular carcinoma. 三维超声融合成像在肝细胞癌热消融术中的精确置针。
IF 3.1 3区 医学 Q2 ONCOLOGY Pub Date : 2024-01-01 Epub Date: 2024-02-15 DOI: 10.1080/02656736.2024.2316097
Jiaming Liu, Yuqing Guo, Yueting Sun, Ming Liu, Xiaoer Zhang, Ruiying Zheng, Longfei Cong, Baoxian Liu, Xiaoyan Xie, Guangliang Huang

Purpose: To investigate the value of three-dimensional ultrasound fusion imaging (3DUS FI) technique for guiding needle placement in hepatocellular carcinoma (HCC) thermal ablation.

Methods: A total of 57 patients with 60 HCCs with 3DUS FI-guided thermal ablation were retrospectively included in the study. 3DUS volume data of liver were acquired preoperatively by freehand scanning with the tumor and predetermined 5 mm ablative margin automatically segmented. Plan of needle placement was made through a predetermined simulated ablation zone to ensure a 5 mm ablative margin with the coverage rate toward tumor and ablative margin. With real-time ultrasound and 3DUS fusion imaging, ablation needles were placed according to the plan. After ablation, the ablative margin was immediately evaluated by contrast-enhanced ultrasound and 3DUS fusion imaging. The rate of adequate ablative margin, complete response (CR), local tumor progression (LTP), disease-free survival (DFS), and overall survival (OS) was evaluated.

Results: According to postoperative contrast-enhanced CT or MR imaging, the complete response rate was 100% (60/60), and 83% of tumors (30/36) achieved adequate ablative margin (>5 mm) three-dimensionally. During the follow-up period of 6.0-42.6 months, LTP occurred in 5 lesions, with 1- and 2-year LTP rates being 7.0% and 9.4%. The 1- and 2-year DFS rates were 76.1% and 65.6%, and 1- and 2-year OS rates were 98.1% and 94.0%. No major complications or ablation-related deaths were observed in any patients.

Conclusions: Three-dimensional ultrasound fusion imaging technique may improve the needle placement of thermal ablation for HCC and reduce the rate of LTP.

目的:探讨三维超声融合成像(3DUS FI)技术在肝细胞癌(HCC)热消融术中引导穿刺针置入的价值:研究回顾性地纳入了57例60个HCC患者,这些患者均在3DUS FI引导下接受了热消融术。术前通过自由扫描获取肝脏的三维超声体积数据,并自动分割肿瘤和预定的 5 毫米消融边缘。通过预先确定的模拟消融区制定进针计划,以确保 5 毫米的消融边缘,并确保肿瘤和消融边缘的覆盖率。通过实时超声和 3DUS 融合成像,消融针按计划放置。消融后,立即通过对比增强超声和三维超声融合成像对消融边缘进行评估。结果:根据术后对比增强CT或MR成像结果,完全反应率为100%(60/60),83%的肿瘤(30/36)三维达到了足够的消融边缘(>5毫米)。在6.0-42.6个月的随访期间,5个病灶发生了LTP,1年和2年LTP率分别为7.0%和9.4%。1年和2年的DFS率分别为76.1%和65.6%,1年和2年的OS率分别为98.1%和94.0%。所有患者均未出现重大并发症或与消融相关的死亡:结论:三维超声融合成像技术可改善 HCC 热消融的进针位置,降低 LTP 发生率。
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引用次数: 0
Efficacy and influencing factor analysis of high-intensity focused ultrasound therapy for abdominal wall endometriosis: a case series. 高强度聚焦超声治疗腹壁子宫内膜异位症的疗效和影响因素分析:病例系列。
IF 3.1 3区 医学 Q2 ONCOLOGY Pub Date : 2024-01-01 Epub Date: 2024-02-27 DOI: 10.1080/02656736.2024.2320416
Hui Cheng, Xiaogang Zhu, Yuyin He, Mengying Liu, Min Xue, Xin Sun

Objective: The aim of this retrospective study was to investigate the short-term and long-term efficacy of high-intensity focused ultrasound (HIFU) therapy for abdominal wall endometriosis (AWE) and explore its potential influencing factors.

Materials and methods: A total of 80 patients with AWE who underwent HIFU therapy were retrospectively analyzed. Follow-ups were also conducted to evaluate the changes in lesion size and pain relief. Multivariate logistic regression analysis was applied to investigate factors influencing HIFU therapy for AWE.

Results: Among the 80 patients with AWE who received HIFU therapy, the effective rates were 76.3%, 80.5%, and 90.5% after 3, 12 and 24 months of follow-up, respectively. Multivariate logistic regression analysis revealed that the AWE lesion diameter and sonication intensity had statistically significant effects on the 3-month and 12-month efficacy of HIFU therapy for AWE, while age, BMI, disease duration, average sonication power and grey-scale changes did not have statistically significant effects. Four patients with AWE experienced recurrence after HIFU therapy, for a three-year cumulative recurrence rate of 6.3%. Furthermore, ten patients required reintervention after treatment, for a five-year cumulative reintervention rate of 13.9%.

Conclusions: This study further confirmed the safety and effectiveness of HIFU therapy for AWE. Factors such as AWE lesion diameter and sonication intensity have been identified as key influencers affecting the short-term and long-term efficacy of HIFU therapy for AWE. The first two years following HIFU therapy constitute crucial periods for observation, and judiciously extending follow-up intervals during this timeframe is advised.

目的:这项回顾性研究旨在调查高强度聚焦超声(HIFU)治疗腹壁子宫内膜异位症(AWE)的短期和长期疗效,并探讨其潜在的影响因素:回顾性分析了80例接受HIFU治疗的腹壁子宫内膜异位症患者。材料: 对接受 HIFU 治疗的 80 例 AWE 患者进行回顾性分析,并进行随访以评估病灶大小和疼痛缓解情况的变化。应用多变量逻辑回归分析研究影响HIFU治疗AWE的因素:结果:在接受 HIFU 治疗的 80 位 AWE 患者中,随访 3 个月、12 个月和 24 个月后的有效率分别为 76.3%、80.5% 和 90.5%。多变量逻辑回归分析显示,AWE病灶直径和超声强度对HIFU治疗AWE的3个月和12个月疗效有显著的统计学影响,而年龄、体重指数、病程、平均超声功率和灰阶变化则没有显著的统计学影响。4名AWE患者在接受HIFU治疗后复发,三年累计复发率为6.3%。此外,10 名患者在治疗后需要再次介入,五年累计再次介入率为 13.9%:本研究进一步证实了 HIFU 治疗 AWE 的安全性和有效性。AWE病灶直径和超声强度等因素被认为是影响HIFU治疗AWE短期和长期疗效的关键因素。HIFU治疗后的头两年是观察的关键时期,建议在此期间明智地延长随访间隔。
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引用次数: 0
Heat therapy in rheumatic and musculoskeletal diseases - an overview of clinical and molecular effects. 风湿病和肌肉骨骼疾病的热疗--临床和分子效应概述。
IF 3.1 3区 医学 Q2 ONCOLOGY Pub Date : 2024-01-01 Epub Date: 2024-03-04 DOI: 10.1080/02656736.2024.2322667
Philipp Klemm, Nils Schulz, Priyanka Boettger, Uwe Lange

Rheumatic and musculoskeletal diseases (RMDs) usually lead to morphological and functional deficits of various extend, increased morbidity and a considerable loss of quality of life. Modern pharmacological treatment has become effective and can stop disease progression. Nonetheless, disease progression is often only slowed down. Moreover, pharmacological treatment does not improve functionality per se. Therefore, multimodal treatment of rheumatic disorders with physical therapy being a key element is of central importance for best outcomes. In recent years, research into physical medicine shifted from a sole investigation of its clinical effects to a combined investigation of clinical effects and potential changes in the molecular level (e.g., inflammatory cytokines and the cellular autoimmune system), thus offering new explanations of clinical effects of physical therapy. In this review we provide an overview of studies investigating different heat applications in RMDs, their effect on disease activity, pain and their influence on the molecular level.

风湿病和肌肉骨骼疾病(RMDs)通常会导致不同程度的形态和功能障碍、发病率增加以及生活质量大幅下降。现代药物治疗非常有效,可以阻止疾病的发展。然而,疾病的进展往往只能延缓。此外,药物治疗本身并不能改善功能。因此,以物理治疗为关键因素的风湿性疾病多模式治疗对于取得最佳疗效至关重要。近年来,物理医学研究从单纯研究其临床效果转向综合研究临床效果和分子水平的潜在变化(如炎症细胞因子和细胞自身免疫系统),从而为物理治疗的临床效果提供了新的解释。在这篇综述中,我们概述了对 RMD 中不同热应用的研究,以及这些热应用对疾病活动、疼痛的影响及其对分子水平的影响。
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引用次数: 0
Ultrasound-guided percutaneous microwave ablation of primary hyperthyroidism: security and efficacy analysis. 超声引导下经皮微波消融治疗原发性甲状腺功能亢进症:安全性和疗效分析。
IF 3 3区 医学 Q2 ONCOLOGY Pub Date : 2024-01-01 Epub Date: 2024-11-12 DOI: 10.1080/02656736.2024.2424903
Jing-E Zhu, Chun-Jun Sheng, Hui-Li Zhang, Jia-Xin Li, Xiao-Wan Bo, Jia-Jing Yin, Peng Yang, Song-Yuan Yu, Li-Ping Sun

Objectives: This study aimed to analyze the safety, efficacy, and application prospects of ultrasound-guided microwave ablation (MWA) in the treatment of primary hyperthyroidism.

Methods: Eight patients with primary hyperthyroidism who underwent ultrasound-guided glandular volume reduction between January 2021 and December 2022 were included in this study. Pre- and postablative examinations, including grayscale ultrasound, contrast-enhanced ultrasound (CEUS), laboratory examination, antithyroid drug (ATD) dosage, and quality of life (QoL) assessment via Thyroid-Specific Patient-Reported Outcome Short-Form (ThyPRO-39), were analyzed retrospectively. The main ultrasound follow-up times were 1, 3, 6, and 12 months after ablation. Thyroid function was reviewed 1 week after ablation, and the subsequent reexamination time was determined according to the patient's specific test results and ATD adjustment. The final efficacy was comprehensively analyzed according to the patient's medication status, thyroid function, thyroid volume, and QoL score.

Results: All 8 patients successfully received MWA for primary hyperthyroidism, and none of them experienced serious complications. By the end of the follow-up, 5 of the 8 patients had stopped taking ATDs, 3 of the 8 patients had reduced ATD dosages, and all of them maintained stable thyroid function. Although descriptive analysis was performed because of the small sample size, patients' thyroid volume reduction, and obvious improvements in goiter symptoms, hyperthyroid symptoms, anxiety, etc., were observed during our follow-up.

Conclusion: Ultrasound-guided MWA for reducing thyroid gland volume in primary hyperthyroidism patients is a new, safe, and effective minimally invasive treatment method that is a good choice for patients who cannot or refuse traditional treatment methods.

研究目的本研究旨在分析超声引导下微波消融术(MWA)治疗原发性甲亢的安全性、有效性和应用前景:研究纳入了2021年1月至2022年12月期间接受超声引导下腺体体积缩小术的8例原发性甲状腺功能亢进症患者。研究回顾性分析了消融术前和消融术后的检查,包括灰阶超声、对比增强超声(CEUS)、实验室检查、抗甲状腺药物(ATD)剂量以及通过甲状腺特异性患者报告结果短表(ThyPRO-39)进行的生活质量(QoL)评估。主要超声随访时间为消融术后 1、3、6 和 12 个月。消融术后 1 周复查甲状腺功能,根据患者的具体检查结果和 ATD 调整情况确定后续复查时间。根据患者的用药情况、甲状腺功能、甲状腺体积和 QoL 评分综合分析最终疗效:8例原发性甲亢患者均成功接受了MWA治疗,无一例出现严重并发症。随访结束时,8 名患者中有 5 人停止了 ATD 的服用,3 人减少了 ATD 的剂量,所有患者的甲状腺功能均保持稳定。虽然由于样本量较小,我们只进行了描述性分析,但在随访过程中,我们观察到患者甲状腺体积缩小,甲状腺肿大症状、甲亢症状、焦虑等明显改善:结论:超声引导下甲状腺肿大减容术是一种新型、安全、有效的微创治疗方法,对于无法接受或拒绝传统治疗方法的患者来说是一种不错的选择。
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引用次数: 0
HMGB1 released from pyroptotic vascular endothelial cells promotes immune disorders in exertional heatstroke. 发热血管内皮细胞释放的 HMGB1 会促进劳累性中暑的免疫紊乱。
IF 3 3区 医学 Q2 ONCOLOGY Pub Date : 2024-01-01 Epub Date: 2024-08-08 DOI: 10.1080/02656736.2024.2378867
Chaoping Yu, Yang Huang, Jiangang Xie, Chujun Duan, Shanshou Liu, Wei Zhao, Yutong Wang, Ran Zhuang, Junjie Li, Wen Yin

Background and objective: Exertional heatstroke (EHS) mainly occurs in healthy young people with rapid onset and high mortality. EHS immune disorders can cause systemic inflammatory responses and multiple organ failure; however, the underlying mechanisms remain unclear. As high mobility group box 1 (HMGB1) is a prototypical alarmin that activates inflammatory and immune responses, this study aimed to investigate the effect and mechanism of HMGB1 in the pathogenesis of EHS.

Methods: Peripheral blood mononuclear cell (PBMC) transcriptome sequencing of healthy volunteers, classical heatstroke patients, and EHS patients was performed. A mouse model of EHS was established and murine tissue damage was evaluated by H&E staining. HMGB1 localization and release were visualized using immunofluorescence staining. Human umbilical vein endothelial cells (HUVECs) and THP-1 cells were co-cultured to study the effects of HMGB1 on macrophages. A neutralizing anti-HMGB1 antibody was used to evaluate the efficacy of EHS treatment in mice.

Results: Plasma and serum HMGB1 levels were significantly increased in EHS patients or mice. EHS-induced endothelial cell pyroptosis promoted HMGB1 release in mice. HMGB1 derived from endothelial cell pyroptosis enhanced macrophage pyroptosis, resulting in immune disorders under EHS conditions. Administration of anti-HMGB1 markedly alleviated tissue injury and systemic inflammatory responses after EHS.

Conclusions: The release of HMGB1 from pyroptotic endothelial cells after EHS promotes pyroptosis of macrophages and systemic inflammatory response, and HMGB1-neutralizing antibody therapy has good application prospects for EHS.

背景和目的:劳累性中暑(EHS)主要发生在健康的年轻人身上,发病急、死亡率高。EHS 免疫紊乱可引起全身炎症反应和多器官功能衰竭;然而,其潜在机制仍不清楚。由于高迁移率基团框1(HMGB1)是激活炎症和免疫反应的典型警报蛋白,本研究旨在探讨HMGB1在EHS发病机制中的作用和机制:方法:对健康志愿者、典型中暑患者和 EHS 患者的外周血单核细胞(PBMC)转录组进行测序。建立了 EHS 小鼠模型,并通过 H&E 染色评估了小鼠组织损伤情况。采用免疫荧光染色法观察 HMGB1 的定位和释放情况。为了研究 HMGB1 对巨噬细胞的影响,研究人员将人脐静脉内皮细胞(HUVECs)和 THP-1 细胞进行了联合培养。使用中和抗 HMGB1 抗体评估 EHS 治疗小鼠的疗效:结果:EHS患者或小鼠血浆和血清中的HMGB1水平明显升高。EHS诱导的小鼠内皮细胞热解促进了HMGB1的释放。内皮细胞脓毒症产生的 HMGB1 增强了巨噬细胞的脓毒症,导致 EHS 条件下的免疫紊乱。服用抗 HMGB1 可明显减轻 EHS 后的组织损伤和全身炎症反应:结论:EHS后嗜热内皮细胞释放的HMGB1促进了巨噬细胞的嗜热和全身炎症反应,HMGB1中和抗体疗法在EHS中具有良好的应用前景。
{"title":"HMGB1 released from pyroptotic vascular endothelial cells promotes immune disorders in exertional heatstroke.","authors":"Chaoping Yu, Yang Huang, Jiangang Xie, Chujun Duan, Shanshou Liu, Wei Zhao, Yutong Wang, Ran Zhuang, Junjie Li, Wen Yin","doi":"10.1080/02656736.2024.2378867","DOIUrl":"10.1080/02656736.2024.2378867","url":null,"abstract":"<p><strong>Background and objective: </strong>Exertional heatstroke (EHS) mainly occurs in healthy young people with rapid onset and high mortality. EHS immune disorders can cause systemic inflammatory responses and multiple organ failure; however, the underlying mechanisms remain unclear. As high mobility group box 1 (HMGB1) is a prototypical alarmin that activates inflammatory and immune responses, this study aimed to investigate the effect and mechanism of HMGB1 in the pathogenesis of EHS.</p><p><strong>Methods: </strong>Peripheral blood mononuclear cell (PBMC) transcriptome sequencing of healthy volunteers, classical heatstroke patients, and EHS patients was performed. A mouse model of EHS was established and murine tissue damage was evaluated by H&E staining. HMGB1 localization and release were visualized using immunofluorescence staining. Human umbilical vein endothelial cells (HUVECs) and THP-1 cells were co-cultured to study the effects of HMGB1 on macrophages. A neutralizing anti-HMGB1 antibody was used to evaluate the efficacy of EHS treatment in mice.</p><p><strong>Results: </strong>Plasma and serum HMGB1 levels were significantly increased in EHS patients or mice. EHS-induced endothelial cell pyroptosis promoted HMGB1 release in mice. HMGB1 derived from endothelial cell pyroptosis enhanced macrophage pyroptosis, resulting in immune disorders under EHS conditions. Administration of anti-HMGB1 markedly alleviated tissue injury and systemic inflammatory responses after EHS.</p><p><strong>Conclusions: </strong>The release of HMGB1 from pyroptotic endothelial cells after EHS promotes pyroptosis of macrophages and systemic inflammatory response, and HMGB1-neutralizing antibody therapy has good application prospects for EHS.</p>","PeriodicalId":14137,"journal":{"name":"International Journal of Hyperthermia","volume":"41 1","pages":"2378867"},"PeriodicalIF":3.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141906543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microwave ablation for recurrent primary hyperparathyroidism in four patients with multiple endocrine neoplasia type 1: a case series report. 微波消融治疗四例多发性内分泌肿瘤1型患者的复发性原发性甲状旁腺功能亢进症:病例系列报告。
IF 3.1 3区 医学 Q2 ONCOLOGY Pub Date : 2024-01-01 Epub Date: 2024-02-05 DOI: 10.1080/02656736.2024.2308056
Jie Tan, Yuzhi Zhang, Xue Han, Yaofu Fan, Juan Xu, Guofang Chen, Chao Liu, Shuhang Xu

Multiple endocrine neoplasia type 1 (MEN1), a rare tumor syndrome, is inherited in an autosomal dominant pattern, mainly manifested as primary hyperparathyroidism (PHPT). Surgery is preferred for patients with MEN1 and PHPT. Thermal ablation has been widely applied for PHPT but rarely for postoperative recurrent PHPT in MEN1 patients. Based on a series of cases, we aimed to investigate the clinical efficacy and safety of ultrasound-guided percutaneous microwave ablation in the treatment of MEN1 patients with postoperative recurrence of PHPT.

多发性内分泌肿瘤 1 型(MEN1)是一种罕见的肿瘤综合征,为常染色体显性遗传,主要表现为原发性甲状旁腺功能亢进症(PHPT)。MEN1和PHPT患者首选手术治疗。热消融已广泛应用于PHPT,但很少用于MEN1患者术后复发的PHPT。基于一系列病例,我们旨在研究超声引导下经皮微波消融术治疗MEN1患者术后复发PHPT的临床疗效和安全性。
{"title":"Microwave ablation for recurrent primary hyperparathyroidism in four patients with multiple endocrine neoplasia type 1: a case series report.","authors":"Jie Tan, Yuzhi Zhang, Xue Han, Yaofu Fan, Juan Xu, Guofang Chen, Chao Liu, Shuhang Xu","doi":"10.1080/02656736.2024.2308056","DOIUrl":"10.1080/02656736.2024.2308056","url":null,"abstract":"<p><p>Multiple endocrine neoplasia type 1 (MEN1), a rare tumor syndrome, is inherited in an autosomal dominant pattern, mainly manifested as primary hyperparathyroidism (PHPT). Surgery is preferred for patients with MEN1 and PHPT. Thermal ablation has been widely applied for PHPT but rarely for postoperative recurrent PHPT in MEN1 patients. Based on a series of cases, we aimed to investigate the clinical efficacy and safety of ultrasound-guided percutaneous microwave ablation in the treatment of MEN1 patients with postoperative recurrence of PHPT.</p>","PeriodicalId":14137,"journal":{"name":"International Journal of Hyperthermia","volume":"41 1","pages":"2308056"},"PeriodicalIF":3.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139681092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of acoustic-thermal simulations of in vivo magnetic resonance guided focused ultrasound ablative therapy. 评估体内磁共振引导聚焦超声消融治疗的声热模拟。
IF 3.1 3区 医学 Q2 ONCOLOGY Pub Date : 2024-01-01 Epub Date: 2024-01-17 DOI: 10.1080/02656736.2023.2301489
Nicholas Richards, Douglas Christensen, Joshua Hillyard, Michelle Kline, Sara Johnson, Henrik Odéen, Allison Payne

Purpose: To evaluate numerical simulations of focused ultrasound (FUS) with a rabbit model, comparing simulated heating characteristics with magnetic resonance temperature imaging (MRTI) data collected during in vivo treatment.

Methods: A rabbit model was treated with FUS sonications in the biceps femoris with 3D MRTI collected. Acoustic and thermal properties of the rabbit muscle were determined experimentally. Numerical models of the rabbits were created, and tissue-type-specific properties were assigned. FUS simulations were performed using both the hybrid angular spectrum (HAS) method and k-Wave. Simulated power deposition patterns were converted to temperature maps using a Pennes' bioheat equation-based thermal solver. Agreement of pressure between the simulation techniques and temperature between the simulation and experimental heating was evaluated. Contributions of scattering and absorption attenuation were considered.

Results: Simulated peak pressures derived using the HAS method exceeded the simulated peak pressures from k-Wave by 1.6 ± 2.7%. The location and FWHM of the peak pressure calculated from HAS and k-Wave showed good agreement. When muscle acoustic absorption value in the simulations was adjusted to approximately 54% of the measured attenuation, the average root-mean-squared error between simulated and experimental spatial-average temperature profiles was 0.046 ± 0.019 °C/W. Mean distance between simulated and experimental COTMs was 3.25 ± 1.37 mm. Transverse FWHMs of simulated sonications were smaller than in in vivo sonications. Longitudinal FWHMs were similar.

Conclusions: Presented results demonstrate agreement between HAS and k-Wave simulations and that FUS simulations can accurately predict focal position and heating for in vivo applications in soft tissue.

目的:评估兔模型聚焦超声(FUS)的数值模拟,将模拟加热特性与体内治疗期间收集的磁共振温度成像(MRTI)数据进行比较:对兔子模型的股二头肌进行 FUS 声波治疗,并收集三维 MRTI 数据。实验确定了兔子肌肉的声学和热学特性。创建了兔子的数字模型,并分配了特定组织类型的属性。使用混合角频谱 (HAS) 方法和 k 波进行了 FUS 模拟。使用基于潘尼斯生物热方程的热求解器将模拟的功率沉积模式转换为温度图。评估了模拟技术之间压力的一致性以及模拟和实验加热之间温度的一致性。结果:结果:使用 HAS 方法得出的模拟峰值压力比 k-Wave 模拟峰值压力高出 1.6 ± 2.7%。HAS 和 k-Wave 计算出的峰值压力的位置和 FWHM 显示出良好的一致性。当模拟中的肌肉吸声值调整为测量衰减的 54% 左右时,模拟和实验空间平均温度曲线的平均均方根误差为 0.046 ± 0.019 °C/W。模拟和实验 COTM 之间的平均距离为 3.25 ± 1.37 毫米。模拟声波的横向 FWHM 小于活体声波。结论:上述结果表明,HAS 和 k 波模拟结果一致,FUS 模拟可准确预测软组织体内应用的焦点位置和加热情况。
{"title":"Evaluation of acoustic-thermal simulations of in vivo magnetic resonance guided focused ultrasound ablative therapy.","authors":"Nicholas Richards, Douglas Christensen, Joshua Hillyard, Michelle Kline, Sara Johnson, Henrik Odéen, Allison Payne","doi":"10.1080/02656736.2023.2301489","DOIUrl":"10.1080/02656736.2023.2301489","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate numerical simulations of focused ultrasound (FUS) with a rabbit model, comparing simulated heating characteristics with magnetic resonance temperature imaging (MRTI) data collected during <i>in vivo</i> treatment.</p><p><strong>Methods: </strong>A rabbit model was treated with FUS sonications in the biceps femoris with 3D MRTI collected. Acoustic and thermal properties of the rabbit muscle were determined experimentally. Numerical models of the rabbits were created, and tissue-type-specific properties were assigned. FUS simulations were performed using both the hybrid angular spectrum (HAS) method and k-Wave. Simulated power deposition patterns were converted to temperature maps using a Pennes' bioheat equation-based thermal solver. Agreement of pressure between the simulation techniques and temperature between the simulation and experimental heating was evaluated. Contributions of scattering and absorption attenuation were considered.</p><p><strong>Results: </strong>Simulated peak pressures derived using the HAS method exceeded the simulated peak pressures from k-Wave by 1.6 ± 2.7%. The location and FWHM of the peak pressure calculated from HAS and k-Wave showed good agreement. When muscle acoustic absorption value in the simulations was adjusted to approximately 54% of the measured attenuation, the average root-mean-squared error between simulated and experimental spatial-average temperature profiles was 0.046 ± 0.019 °C/W. Mean distance between simulated and experimental COTMs was 3.25 ± 1.37 mm. Transverse FWHMs of simulated sonications were smaller than in <i>in vivo</i> sonications. Longitudinal FWHMs were similar.</p><p><strong>Conclusions: </strong>Presented results demonstrate agreement between HAS and k-Wave simulations and that FUS simulations can accurately predict focal position and heating for <i>in vivo</i> applications in soft tissue.</p>","PeriodicalId":14137,"journal":{"name":"International Journal of Hyperthermia","volume":"41 1","pages":"2301489"},"PeriodicalIF":3.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10903184/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139485401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-term outcome and risk factors of reintervention after high intensity focused ultrasound ablation for uterine fibroids: a systematic review and meta-analysis. 子宫肌瘤高强度聚焦超声消融术后的长期疗效和再次介入的风险因素:系统回顾和荟萃分析。
IF 3.1 3区 医学 Q2 ONCOLOGY Pub Date : 2024-01-01 Epub Date: 2024-01-02 DOI: 10.1080/02656736.2023.2299479
Yuya Dou, Lian Zhang, Yu Liu, Min He, Yanzhou Wang, Zhibiao Wang

Objectives: To quantify the reintervention rate and analyze the risk factors for reintervention after high-intensity focused ultrasound (HIFU) ablation of uterine fibroids.

Methods: Eighteen studies were selected from the seven databases. A meta-analysis was applied to synthesize the reintervention rates for fibroids across various follow-up durations. Subgroup-analysis was conducted based on the year of surgery, sample size, guide methods, and non-perfusion volume ratio (NPVR). Signal intensity of T2-weighted imaging (T2WI) was independently evaluated for reintervention risk.

Results: The study enrolled 5216 patients with fibroids treated with HIFU. There were 3247, 1239, 1762, and 2535 women reaching reintervention rates of 1% (95% confidence interval (CI): 1-1), 7% (95% CI: 4-11), 19% (95% CI: 11-27), and 29% (95% CI: 14-44) at 12, 24, 36, and 60-month after HIFU. The reintervention rates of patients treated with US-guided HIFU (USgHIFU) were significantly lower than those of patients treated with MR-guided focused ultrasound surgery (MRgFUS). When the NPVR of fibroids was over 50%, the reintervention rates at 12, 36 and 60-month after HIFU were 1% (95% CI: 0.3-2), 5% (95% CI: 3-8), and 15% (95% CI: 9-20). The reintervention risk for hyper-intensity fibroids on T2WI was 3.45 times higher (95% CI: 2.7-4.39) for hypo-/iso-intensity fibroids.

Conclusion: This meta-analysis showed that the overall reintervention rates after HIFU were acceptable and provided consultative suggestions regarding treatment alternatives for patients with fibroids. Subgroup-analysis revealed that USgHIFU, NPVR ≥ 50%, and hypo-/iso-intensity of fibroids on T2WI were significant factors in reducing reintervention.

Systematic review registration: PROSPERO, CRD42023456094.

目的量化子宫肌瘤高强度聚焦超声(HIFU)消融术后的再介入率,并分析再介入的风险因素:方法:从七个数据库中筛选出 18 项研究。方法:从 7 个数据库中选取了 18 项研究,采用荟萃分析法对不同随访期的子宫肌瘤再干预率进行综合分析。根据手术年份、样本大小、引导方法和非灌注容积比(NPVR)进行了分组分析。T2加权成像(T2WI)的信号强度是再次介入风险的独立评估指标:研究共纳入了5216名接受HIFU治疗的子宫肌瘤患者。在HIFU治疗后12、24、36和60个月,分别有3247、1239、1762和2535名妇女的再干预率分别为1%(95%置信区间(CI):1-1)、7%(95% CI:4-11)、19%(95% CI:11-27)和29%(95% CI:14-44)。采用 USgHIFU 治疗的患者的再干预率明显低于采用 MRgFUS 治疗的患者。当子宫肌瘤的NPVR超过50%时,HIFU治疗后12个月、36个月和60个月的再干预率分别为1%(95% CI:0.3-2)、5%(95% CI:3-8)和15%(95% CI:9-20)。T2WI上高密度肌瘤的再干预风险是低密度/等密度肌瘤的3.45倍(95% CI:2.7-4.39):这项荟萃分析表明,HIFU术后的总体再介入率是可以接受的,并为子宫肌瘤患者提供了替代治疗的咨询建议。亚组分析显示,USgHIFU、NPVR≥50%以及T2WI上肌瘤的低强度/等强度是减少再干预的重要因素:prospero,CRD42023456094。
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引用次数: 0
Construction of a 12-gene prognostic model for colorectal cancer based on heat shock protein-related genes. 基于热休克蛋白相关基因构建结直肠癌 12 基因预后模型。
IF 3.1 3区 医学 Q2 ONCOLOGY Pub Date : 2024-01-01 Epub Date: 2024-01-08 DOI: 10.1080/02656736.2023.2290913
Qin Tong, Junchao Zhou

Some heat shock proteins (HSPs) have been shown to influence tumor prognosis, but their prognostic significance in colorectal cancer (CRC) remains unclear. This study explored the prognostic significance of HSP-related genes in CRC. Transcriptional data and clinical information of CRC patients were obtained from The Cancer Genome Atlas (TCGA) database, and a literature search was conducted to identify HSP-related genes. Using Least Absolute Selection and Shrinkage Operator (LASSO) regression and univariate/multivariate Cox regression analyses, 12 HSP-related genes demonstrating significant associations with CRC survival were successfully identified and employed to formulate a predictive risk score model. The efficacy and precision of this model were validated utilizing TCGA and Gene Expression Omnibus (GEO) datasets, demonstrating its reliability in CRC prognosis prediction. gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses revealed significant disparities between high- and low-risk groups in chromatin remodeling biological functions and neutrophil extracellular trap formation pathways. Single sample gene set enrichment analysis (ssGSEA) further revealed differences in immune cell types and immune functional status between the two risk groups. Differential analysis showed higher expression of immune checkpoints within the low-risk group, while the high-risk group exhibited notably higher Tumor Immune Dysfunction and Exclusion (TIDE) scores. Additionally, we predicted the sensitivity of different prognosis risk patients to various drugs, providing potential drug choices for tailored treatment. Combined, our study successfully crafted a novel CRC prognostic model that can effectively predict patient survival, immune landscape, and treatment response, providing important support and guidance for CRC patient prognosis.

一些热休克蛋白(HSP)已被证明可影响肿瘤预后,但它们在结直肠癌(CRC)中的预后意义仍不明确。本研究探讨了 HSP 相关基因在 CRC 中的预后意义。研究人员从癌症基因组图谱(TCGA)数据库中获取了CRC患者的转录数据和临床信息,并进行了文献检索以确定HSP相关基因。利用最小绝对选择和收缩操作器(LASSO)回归和单变量/多变量Cox回归分析,成功鉴定出12个与CRC生存率有显著相关性的HSP相关基因,并利用这些基因建立了一个预测性风险评分模型。基因本体(GO)和京都基因与基因组百科全书(KEGG)富集分析表明,高风险组和低风险组在染色质重塑生物功能和中性粒细胞胞外陷阱形成途径方面存在显著差异。单样本基因组富集分析(ssGSEA)进一步揭示了两个风险组在免疫细胞类型和免疫功能状态方面的差异。差异分析表明,低风险组的免疫检查点表达较高,而高风险组的肿瘤免疫功能障碍和排斥(TIDE)评分明显较高。此外,我们还预测了不同预后风险患者对各种药物的敏感性,为定制治疗提供了潜在的药物选择。综上所述,我们的研究成功地建立了一个新型的 CRC 预后模型,该模型能有效预测患者的生存、免疫状况和治疗反应,为 CRC 患者的预后提供了重要的支持和指导。
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引用次数: 0
Ultrasound-guided high-intensity focused ultrasound ablation for uterine arteriovenous fistula: a case series. 超声引导下高强度聚焦超声消融治疗子宫动静脉瘘:病例系列。
IF 3.1 3区 医学 Q2 ONCOLOGY Pub Date : 2024-01-01 Epub Date: 2024-03-13 DOI: 10.1080/02656736.2024.2325478
Fang Li, Hua Tao, Jing Chen, Li Wang, Yini Wei, Xiajuan Wu, Yu Zhang, Dingyuan Zeng

Purpose: To evaluate the efficacy and safety of high-intensity focused ultrasound (HIFU) ablation in the treatment of uterine arteriovenous fistula (UAVF).

Materials and methods: This case series included three patients diagnosed with acquired UAVF. All patients underwent routine laboratory tests, electrocardiography (ECG), chest X-ray, ultrasound, and pelvic contrast-enhanced magnetic resonance imaging (MRI). HIFU treatment was performed under sedation and analgesia using a Model JC Focused Ultrasound Tumor Therapeutic System (made by Chongqing Haifu Medical Technology Co. Ltd., China) with a B mode ultrasound device for treatment guidance. The treatment time, sonication power, sonication time, and complications were recorded. Follow-up evaluations were scheduled at 1-, 3-, 6-, and 12-month to assess symptom improvement and evaluate the post-treatment imaging.

Results: All patients completed HIFU treatment in a single session without any major complication. All patients complained of mild lower abdominal and sacrococcygeal pain. Typically, no special treatment is required. Following HIFU treatment, there was a significant relief in clinical symptoms, particularly abnormal uterine bleeding. Ultrasound examinations conducted one month after the treatment revealed a notable reduction in the volume of the lesion, ranging from 57% to 100%. Moreover, the efficacy and safety of HIFU treatment remained consistent during the 12-month follow-up period.

Conclusion: HIFU ablation appears to be an effective and safe treatment modality for UAVF. It provides a noninvasive approach with favorable clinical outcomes.

目的:评估高强度聚焦超声(HIFU)消融术治疗子宫动静脉瘘(UAVF)的有效性和安全性:本病例系列包括三名被诊断为获得性子宫动静脉瘘的患者。所有患者均接受了常规实验室检查、心电图(ECG)、胸部 X 光检查、超声波检查和盆腔造影剂增强磁共振成像(MRI)检查。HIFU 治疗是在镇静和镇痛下进行的,使用的是 JC 型聚焦超声肿瘤治疗系统(中国重庆海扶医疗科技有限公司制造),治疗时使用 B 模式超声设备进行引导。记录治疗时间、超声功率、超声时间和并发症。在1、3、6和12个月时进行随访评估,以评估症状改善情况和治疗后影像学评估:结果:所有患者均在一次治疗中完成了 HIFU 治疗,未出现任何重大并发症。所有患者均主诉有轻微的下腹部和骶尾部疼痛。通常情况下,无需特殊治疗。HIFU 治疗后,临床症状明显缓解,尤其是异常子宫出血。治疗一个月后进行的超声波检查显示,病灶体积明显缩小,缩小幅度从 57% 到 100% 不等。此外,在12个月的随访期间,HIFU治疗的有效性和安全性保持一致:结论:HIFU消融似乎是治疗尿道前列腺增生的一种有效而安全的方法。结论:HIFU消融术是治疗尿道前列腺增生症的一种有效、安全的治疗方法,它是一种无创方法,临床效果良好。
{"title":"Ultrasound-guided high-intensity focused ultrasound ablation for uterine arteriovenous fistula: a case series.","authors":"Fang Li, Hua Tao, Jing Chen, Li Wang, Yini Wei, Xiajuan Wu, Yu Zhang, Dingyuan Zeng","doi":"10.1080/02656736.2024.2325478","DOIUrl":"10.1080/02656736.2024.2325478","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the efficacy and safety of high-intensity focused ultrasound (HIFU) ablation in the treatment of uterine arteriovenous fistula (UAVF).</p><p><strong>Materials and methods: </strong>This case series included three patients diagnosed with acquired UAVF. All patients underwent routine laboratory tests, electrocardiography (ECG), chest X-ray, ultrasound, and pelvic contrast-enhanced magnetic resonance imaging (MRI). HIFU treatment was performed under sedation and analgesia using a Model JC Focused Ultrasound Tumor Therapeutic System (made by Chongqing Haifu Medical Technology Co. Ltd., China) with a B mode ultrasound device for treatment guidance. The treatment time, sonication power, sonication time, and complications were recorded. Follow-up evaluations were scheduled at 1-, 3-, 6-, and 12-month to assess symptom improvement and evaluate the post-treatment imaging.</p><p><strong>Results: </strong>All patients completed HIFU treatment in a single session without any major complication. All patients complained of mild lower abdominal and sacrococcygeal pain. Typically, no special treatment is required. Following HIFU treatment, there was a significant relief in clinical symptoms, particularly abnormal uterine bleeding. Ultrasound examinations conducted one month after the treatment revealed a notable reduction in the volume of the lesion, ranging from 57% to 100%. Moreover, the efficacy and safety of HIFU treatment remained consistent during the 12-month follow-up period.</p><p><strong>Conclusion: </strong>HIFU ablation appears to be an effective and safe treatment modality for UAVF. It provides a noninvasive approach with favorable clinical outcomes.</p>","PeriodicalId":14137,"journal":{"name":"International Journal of Hyperthermia","volume":"41 1","pages":"2325478"},"PeriodicalIF":3.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140119480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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International Journal of Hyperthermia
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