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Comparative Study of Anti-Anemic Effect of Some Natural Food Supplements on Rats 几种天然食品补充剂对大鼠抗贫血作用的比较研究
Pub Date : 2021-01-01 DOI: 10.11648/j.ijfsb.20210602.11
Safaa Ahmed Salem, Amany Mohammed Gad, Abdellatif Anaam Kamal
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引用次数: 0
A Review of Non-gluten Components in Gluten-free Bread Characteristics, Dough Baking Quality and Viscoelastic Qualities 无麸质面包中非麸质成分的研究进展
Pub Date : 2021-01-01 DOI: 10.11648/j.ijfsb.20210604.14
Melaku Tafese Awulachew
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引用次数: 1
Traditional Knowledge on Indigenous Foods in the Communities of Tamilnadu- An Exploratory Cross- Sectional Study 泰米尔纳德邦社区土著食物的传统知识——一项探索性的横断面研究
Pub Date : 2021-01-01 DOI: 10.11648/j.ijfsb.20210604.15
Dheephiga Mahendiran, Anusuya Devi Kuppuswamy, Sathiya Viswanathan
: Introduction : Traditional food knowledge is the knowledge passed from one generation to another generation. Ancient Tamil peoples believes “ Unavemarundhu ” which means “Let’s food be thy medicine and medicine be thy food” . Indigenous food system helps to improve the quality of life. Objective : This study was conducted to assess, collect and document the traditional knowledge on indigenous foods followed in the Communities of Tamilnadu. Methods : A cross sectional study was conducted through Focus group discussion and one on one interview method among the 202 selected women Respondents in the age group 30-90 years old. Results : Knowledge assessment of the selected Respondents reveals that the majority of the people from the age group above 80 (71.6%) possess more traditional knowledge. People in the age group of 30-39 (10.5%) years possess least traditional knowledge. Even though we have plenty of awareness about exclusive breast feeding, still most of the Respondents prefer to include the sugar syrup as first food for infants due to superstitious belief. Conclusion : The above study concluded that the traditional knowledge to indigenous food was decreasing gradually, if this situation persists, we may lose our precious traditional knowledge on food in future. Indigenous food preparations are rich in nutraceutical compound which aids for better well being and improve immunity. So it is important to document the indigenous food in order to protect and preserve our traditional knowledge.
传统的食物知识是由一代人传给另一代人的知识。古泰米尔人相信“Unavemarundhu”,意思是“让我们的食物成为你的药物,药物成为你的食物”。土著粮食系统有助于提高生活质量。目的:本研究旨在评估、收集和记录泰米尔纳德邦社区土著食物的传统知识。方法:采用焦点小组讨论法和一对一访谈法对202名30 ~ 90岁的女性受访者进行横断面研究。结果:对所选被调查者的知识评估显示,80岁以上的人群中,大多数人(71.6%)拥有更多的传统知识。30-39岁人群(10.5%)拥有的传统知识最少。尽管我们对纯母乳喂养有足够的认识,但由于迷信的原因,大多数受访者更倾向于将糖浆作为婴儿的第一食物。结论:上述研究表明,传统食物知识正在逐渐减少,如果这种情况持续下去,未来我们可能会失去宝贵的传统食物知识。土著食品制剂富含营养化合物,有助于改善健康和提高免疫力。因此,为了保护和保存我们的传统知识,记录土著食物是很重要的。
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引用次数: 0
Diet and Cardiovascular Diseases Risk: A Case – Control Study at Kushtia, Bangladesh 饮食与心血管疾病风险:孟加拉国库什蒂亚的病例对照研究
Pub Date : 2020-11-04 DOI: 10.11648/J.IJFSB.20200504.14
Tamanna Aktar, Md. Alauddin Biswas
This was a descriptive cross sectional study with purposely selected sample 230 cardiac patient conducted in kushtia sadar Hospital, kushtia. The study was conducted to assess the relation between cardiovascular diseases and dietary patterns of patients suffering from cardiovascular disease. Study results presented that about 26.5% patients were affected in stroke; 80 34.8% patients were affected in heart attack; 17.4% patients were affected in coronary heart disease. Out of total patients, 56.1% were overweight; 22.2% were obese class I; 29.1% male and 15.2% female were centrally obese by their waist circumference; 47.0% male and 34.8% female were centrally obese by their waist-hip ratio. BMI 28.38±3.16 in male and 26.75±4.62 in female, WC (cm) 88.70±9.18 in male and 81.45±11.25 in female and the difference was significant. Waist circumference (WC) was significantly (p=0.000) correlated with Waist-Hip ratio and dietary diversity score; BMI also correlated with WC. Most of the respondents did not know the symptoms of heart disease and dietary knowledge were very poor among the cardiac patients. The findings of the study shows that the prevalence of cardiovascular disease was high among those with positive family history, lower education, poor dietary knowledge, physically inactive, overweight or obese and those with higher WC, WHR were found to have a significant effect on the prevalence of CVD.
这是一项描述性横断面研究,在库什蒂亚sadar医院有目的地选择230例心脏病患者。本研究旨在评估心血管疾病与心血管疾病患者饮食模式之间的关系。研究结果显示,约26.5%的患者发生脑卒中;80 34.8%的患者发生心梗;17.4%的患者发生冠心病。在所有患者中,56.1%超重;肥胖I级占22.2%;以腰围衡量,29.1%的男性和15.2%的女性为中心肥胖;从腰臀比来看,男性为47.0%,女性为34.8%。BMI男性为28.38±3.16,女性为26.75±4.62;WC (cm)男性为88.70±9.18,女性为81.45±11.25,差异有统计学意义。腰围(WC)与腰臀比和饮食多样性评分显著相关(p=0.000);BMI也与腰围相关。大多数受访者不知道心脏病的症状,心脏病患者的饮食知识很差。研究结果显示,家族史阳性、文化程度低、饮食知识差、缺乏运动、超重或肥胖的人群心血管疾病患病率较高,而腰围、腰臀比较高的人群对心血管疾病患病率有显著影响。
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引用次数: 0
Production and Quality Evaluation of Cookies from Wheat, Almond Seed and Carrot Flour Blends 小麦、杏仁籽和胡萝卜粉混合饼干的生产及质量评价
Pub Date : 2020-10-30 DOI: 10.11648/J.IJFSB.20200504.11
Mulak Desmond Guyih, Ahure Dinnah, M. O. Eke
Cookies are a form of baked food which is usually sweet. Wheat, almond and carrot flours were used to produce cookies in the following blend ratios: 100:0:0, 90:10:0, 90:0:10, 80:15:5, 70:20:10 and were labeled A, B, C, D and E. The control sample A was without treatment. Analyses of antinutrients, functional properties, physical, proximate, minerals, and sensory attributes were carried out using standard methods. All the results show statistical difference. The functional properties of flours: bulk density, WAC, OAC, swelling capacity and foaming capacity ranged respectively from 0.71 to 0.81 g/cm3, 1.60 to 4.31 g/mL, 1.10 to 3.67 g/L, 2.30 to 2.66 mL, 5.10 to 6.62%. The antinutritional properties: oxalate, tannin and cyanide content of flours ranged from 0.03 to 0.14 mg/100g, 0.18 to 0.64%, 0.12 to 0.13%, phytate content was not detected. The spread ratio of cookies ranged from 3.32 in sample A to 4.04 in sample E. The proximate composition of cookies: moisture, ash, fiber, fat, protein and carbohydrate content ranged respectively: from 6.42 to 8.04%, 1.62 to 2.72%, 0.36 to 0.97%, 1.94 to 6.02%, 6.14 to 10.23% and 71.27 to 81.18%. The energy value of cookies ranged from 371.22 to 391 kCal. The mineral composition ranged from 185.77 to 230.16 mg/100g for calcium, 877.62 to 984 mg/100g for potassium, 5.75 to 7.12 mg/100g for zinc, 58.96 mg/100g to 77.16 mg/100g for magnesium and 47.03 to 56.12 for sodium. All cookies samples were generally accepted by sensory panelist. The study provides evidence that wheat, almond and carrot are suitable for cookies production and at optimal substitution levels of 70:20:10 and 80:20:10.
饼干是一种烘焙食品,通常是甜的。采用小麦粉、杏仁粉和胡萝卜粉分别以100:0:0、90:10:0、90:0:10、80:15:5、70:20:10的混合比例制作饼干,分别标记为A、B、C、D、e。使用标准方法对抗营养素、功能特性、物理、近似、矿物质和感官特性进行分析。结果均有统计学差异。面粉的功能性能:容重、WAC、OAC、膨胀量和起泡量分别为0.71 ~ 0.81 g/cm3、1.60 ~ 4.31 g/mL、1.10 ~ 3.67 g/L、2.30 ~ 2.66 mL、5.10 ~ 6.62%。抗营养性能:草酸、单宁、氰化物含量分别为0.03 ~ 0.14 mg/100g、0.18 ~ 0.64%、0.12 ~ 0.13%,未检出植酸含量。饼干的扩散比在A样品中为3.32 ~ 4.04,在e样品中为4.04。饼干的近似组成:水分、灰分、纤维、脂肪、蛋白质和碳水化合物含量分别为6.42 ~ 8.04%、1.62 ~ 2.72%、0.36 ~ 0.97%、1.94 ~ 6.02%、6.14 ~ 10.23%和71.27 ~ 81.18%。饼干的能量值为371.22 ~ 391 kCal,钙含量为185.77 ~ 230.16 mg/100g,钾含量为877.62 ~ 984 mg/100g,锌含量为5.75 ~ 7.12 mg/100g,镁含量为58.96 ~ 77.16 mg/100g,钠含量为47.03 ~ 56.12。所有饼干样品都被感官小组成员普遍接受。研究结果表明,小麦、杏仁和胡萝卜在70:20:10和80:20:10的最佳替代水平下适合制作饼干。
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引用次数: 2
The Dose Effect of Whey Protein on Glycemic Control in Adults with Insulin Resistance 乳清蛋白对胰岛素抵抗成人血糖控制的剂量效应
Pub Date : 2020-10-30 DOI: 10.11648/J.IJFSB.20200504.12
Todd J Castleberry, C. Irvine, Ryan A. Gordon, Matthew F. Brisebois, Sarah E Deemer, A. Henderson, Matthew L. Sokoloski, V. Ben-Ezra
Whey protein coupled with a glucose challenge increases insulin secretion and may decrease glucose responses in people with pre-diabetes and type 2 diabetes. These responses may be attributed to whey protein’s effect on the incretins glucagon-like peptide-1 (GLP-1) and glucose dependent insulinotropic polypeptide (GIP). The purpose of this study was to examine the effect of various doses of whey protein on postprandial glycemic control and incretin responses. Participants with insulin resistance (n=9, mean ± SD; age: 64.3 + 8.1 yrs; BMI: 29.4 + 6.0 kg/m2; fasting plasma glucose: 6.9 + 1.2 mmol/l; HbA1c: 6.4 + 0.6%) completed three randomized treatments. Treatment 1 included 250 ml water + 20 g whey protein (T1), and treatment 2 included 250 ml water + 30 g whey protein (T2). The control treatment included 250 ml water (CON). Each treatment was followed by a 50 g oral glucose tolerance test. Incremental area under the curve (iAUC) for insulin increased from CON to T1 (P<0.01, 45.5%), CON to T2 (P<0.01, 61.0%), and T1 to T2 (P<0.01, 28.5%), with a significant decrease in postprandial AUC for glucose with T2 (P=0.04, -41.2%). Neither GIP nor GLP-1 iAUC increased with T1 or T2 compared to CON. However, postprandial glucose iAUC was significantly reduced for T2 compared to CON (P=0.04, -41.2%). There was a dose effect of whey protein on plasma insulin with a significant decrease in postprandial glucose iAUC following T2. Thirty grams of a whey protein preload may be adequate to provide postprandial glycemic improvements in the disease management of type 2 diabetes or pre-diabetes
在糖尿病前期和2型糖尿病患者中,乳清蛋白与葡萄糖挑战相结合会增加胰岛素分泌,并可能降低葡萄糖反应。这些反应可能归因于乳清蛋白对胰高血糖素样肽-1 (GLP-1)和葡萄糖依赖性胰岛素性多肽(GIP)的影响。本研究的目的是研究不同剂量的乳清蛋白对餐后血糖控制和肠促胰岛素反应的影响。胰岛素抵抗患者(n=9, mean±SD;年龄:64.3 + 8.1岁;BMI: 29.4 + 6.0 kg/m2;空腹血糖:6.9 + 1.2 mmol/l;HbA1c: 6.4 + 0.6%)完成了三次随机治疗。处理1为250 ml水+ 20 g乳清蛋白(T1),处理2为250 ml水+ 30 g乳清蛋白(T2)。对照处理为250 ml水(CON)。每次治疗后进行50g口服葡萄糖耐量试验。胰岛素的增量曲线下面积(Incremental area under curve, iAUC)从CON到T1 (P<0.01, 45.5%)、CON到T2 (P<0.01, 61.0%)和T1到T2 (P<0.01, 28.5%)升高,而葡萄糖在T2时的餐后AUC显著降低(P=0.04, -41.2%)。与CON相比,T1或T2时GIP和GLP-1 iAUC均未升高,但与CON相比,T2时餐后葡萄糖iAUC显著降低(P=0.04, -41.2%)。乳清蛋白对血浆胰岛素有剂量效应,T2后餐后血糖iAUC显著降低。在2型糖尿病或糖尿病前期的疾病管理中,30克乳清蛋白预负荷可能足以提供餐后血糖改善
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引用次数: 1
Chemical Composition and Nutritional Value of Some Type of Wild Mushrooms in Blue Nile State 青尼罗州某些野生蘑菇的化学成分和营养价值
Pub Date : 2020-05-15 DOI: 10.11648/J.IJFSB.20200502.12
Ibrahim Omer, Ebrahim Alfaig
This study was conducted to determine the chemical composition and nutritional value for eight samples of edible mushrooms, including seven samples of wild edible mushrooms collected from Blue Nile State and one commercial sample. All samples were classified by Mycokey software program and mushroom expert web site. In addition, the mushrooms varieties found are Agaricus bisporus, Chlorophyllum rhacodes, Agaricus lutosus, Volvariella volvacea, Agaricus impudicus, Agaricus arvensis, Agaricus silvicola and the commercial sample (Agaricus bisporus). Also, toxicity was detected using potassium hydroxide (4%) during collection in the field and for all samples the toxicity test was negative. The results showed that the samples containing varying moisture content between samples ranged from 5.26% to 11.11%. Fat content ranged from 0.94% to 2.99%. Protein content ranged between 19.41% to 34.14%. Ash content ranged from 0.22% to 1.47%. Add to that, the fiber content ranged from 5.25% to 23.86%. Carbohydrate content ranged from 26.76% to 77.91%. The calcium content (mg/kg) ranged from 5.80 to 8.60. The magnesium content (mg/kg) ranged from 3.07 to 5.50. The phosphorus content (mg/kg) ranged from 2.15 to 2.50. The potassium content (mg/kg) ranged from 21.20 to 21.50. The iron content (mg/100g) ranged from 1.30 to 1.55. The zinc content (mg/100g) ranged from 0.51 to 0.52. The copper content (mg/100g) ranged from 0.10 to 0.11. The manganese content (mg/100g) ranged from 0.10 to 0.12. The essential amino acids content (mg/100g) of mushroom samples were: arginine content ranged from 6.30 to 6.40. Histidine content ranged from 1.90 to 2.20. Lysine content ranged from 5.00 to 5.10. Tryptophan content ranged from 0.88 to 0.90. Phenylalanine content ranged from 2.00 to 2.10. Methionine content ranged from 1.00 to 1.15. Threonine content ranged from 4.05 to 4.10. Leucine content ranged from 3.90 to 4.10. Isoleucine content ranged from 5.56 to 5.70. Valine content ranged from 4.20 to 4.50. All samples contain high levels of protein, minerals and essential amino acids. However, the Volvariella volvacea sample is the best sample in terms of containing the protein so it can be entered as a dietary supplement in some processed foods that contain very small amounts of protein.
本研究确定了8个食用菌样品的化学成分和营养价值,其中包括7个采自青尼罗州的野生食用菌样品和1个商业食用菌样品。所有样品均通过Mycokey软件程序和蘑菇专家网站进行分类。此外,发现的蘑菇品种还包括双孢蘑菇、绿吊菇、绿松菇、绿松菇、粗松菇、粗松菇、粗松菇、粗松菇和商业样品(双孢蘑菇)。此外,在现场采集过程中,使用氢氧化钾(4%)检测毒性,所有样品的毒性测试均为阴性。结果表明,样品间含水率变化范围为5.26% ~ 11.11%。脂肪含量为0.94% ~ 2.99%。蛋白质含量在19.41% ~ 34.14%之间。灰分含量为0.22% ~ 1.47%。纤维含量为5.25% ~ 23.86%。碳水化合物含量为26.76% ~ 77.91%。钙含量(mg/kg)在5.80 ~ 8.60之间。镁含量(mg/kg)在3.07 ~ 5.50之间。磷含量(mg/kg)在2.15 ~ 2.50之间。钾含量(mg/kg)在21.20 ~ 21.50之间。铁含量(mg/100g)在1.30 ~ 1.55之间。锌含量(mg/100g)在0.51 ~ 0.52之间。铜含量(mg/100g)在0.10 ~ 0.11之间。锰含量(mg/100g)在0.10 ~ 0.12之间。香菇样品的必需氨基酸含量(mg/100g)为:精氨酸含量为6.30 ~ 6.40。组氨酸含量在1.90 ~ 2.20之间。赖氨酸含量在5.00 ~ 5.10之间。色氨酸含量在0.88 ~ 0.90之间。苯丙氨酸含量为2.00 ~ 2.10。蛋氨酸含量在1.00 ~ 1.15之间。苏氨酸含量在4.05 ~ 4.10之间。亮氨酸含量在3.90 ~ 4.10之间。异亮氨酸含量为5.56 ~ 5.70。缬氨酸含量从4.20到4.50不等。所有样品都含有高水平的蛋白质、矿物质和必需氨基酸。然而,就蛋白质含量而言,羊粪草样本是最好的样本所以它可以作为膳食补充剂加入到一些含有少量蛋白质的加工食品中。
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引用次数: 2
Quality Assessment of Oven Dried and Traditional Sun Dried Channa Punctatus 炉干和传统晒干马尾莲的质量评价
Pub Date : 2019-12-23 DOI: 10.11648/J.IJFSB.20190404.13
S. N. Jahan, Salma Akhtar
The aim of the present study was to compare the quality assessment in terms of freshness, chemical composition and bacterial load of sun dried fishes and oven dried Channapunctatus during July 2017 to December 2017. Traditionally dried and fresh raw C. punctatus were collected from the Singrabajar of Chalanbeel area, Bangladesh and brought into the laboratory of Department of Fisheries of University of Rajshahi, Bangladesh. Fresh species were processed and dried in the electric oven at 105°C. After the organoleptic analysis it was observed that the appearance, odor, color, texture and overall acceptability of traditionally sun dried fishes were 6.75±0.43, 7.00±0.00, 7.12±0.78, 6.62±0.51, 6.75±0.46 and oven dried fishes were 7.75±1.29, 6.87±0.92, 7.25±1.63, 7.5±1.30 and 7.50±1.30, respectively. Significant difference was found between the sun dried and oven dried C. punctatus for the mean values of all organoleptic characteristics. In case of proximate composition the lipid, protein, ash and moisture contents were 3.10±0.60%, 57.50±2.30%, 21.00±1.20% and 14.83±1.45% in sun dried fishes and 5.85±1.25%, 70.15±1.30%, 13.00±1.50% and 8.50±1.40% was observed in oven dried fish. Significant difference was found in proximate composition. The pH contents varied from 6.3±0.31 (oven dried) to 6.75±0.70 (sun dried). The lowest TVB-N content (3.85mg/100g) was found in oven dried fishes and the highest (4.02mg/100g) was found in sun dried fishes and the microbial load varied from 4.9×102 (oven dried) to 3.9×103 (sun dried). Significant difference was found between the sun and oven dried C. punctatus for the aerobic plate count and TVB-N, but those are belongs in acceptable range.
本研究的目的是比较2017年7月至2017年12月期间晒干鱼和烘箱干鱼在新鲜度、化学成分和细菌负荷方面的质量评估。从孟加拉国Chalanbeel地区的Singrabajar收集了传统干燥和新鲜的生刺棘鱼,并将其带入孟加拉国拉杰沙希大学渔业系实验室。新鲜的品种在105°C的电烤箱中加工和干燥。经感官分析,传统晒干鱼的外观、气味、颜色、质地和总体可接受度分别为6.75±0.43、7.00±0.00、7.12±0.78、6.62±0.51、6.75±0.46,烘箱干鱼的外观、气味、颜色、质地和总体可接受度分别为7.75±1.29、6.87±0.92、7.25±1.63、7.5±1.30和7.50±1.30。晒干和烘干马尾松各感官特征的平均值有显著差异。太阳干鱼的脂肪、蛋白质、灰分和水分含量分别为3.10±0.60%、57.50±2.30%、21.00±1.20%和14.83±1.45%,烘箱干鱼的脂肪、蛋白质、灰分和水分含量分别为5.85±1.25%、70.15±1.30%、13.00±1.50%和8.50±1.40%。在近似成分上发现显著差异。pH值从6.3±0.31(烘箱干燥)到6.75±0.70(晒干)不等。蒸干鱼的TVB-N含量最低(3.85mg/100g),晒干鱼的TVB-N含量最高(4.02mg/100g),微生物负荷从4.9×102(烘干)到3.9×103(晒干)不等。晒干与烘箱干燥马刺鱼的好氧板数和TVB-N差异显著,但属于可接受的范围。
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引用次数: 3
Electron Microscopic Studies in Escherichia Coli on Mode of Action of Sodium Benzoate and Potassium Sorbate 苯甲酸钠和山梨酸钾在大肠杆菌中作用方式的电镜研究
Pub Date : 2019-10-24 DOI: 10.11648/J.IJFSB.20190404.11
N. A. Santiesteban-López, Teresa Gladys Cerón-Carrillo, Jose Luis Carmona-Silva, J. Castro‐Rosas
Traditionally food antimicrobials was utilized to extent the lag phase or inhibit the growth of microorganisms; however, it has been demonstrated that exposure to antimicrobials such as sodium benzoate and potassium sorbate in sublethal concentrations, and gradually increasing the dose, allowed the adaptation of microorganisms of interest in food, such as E. coli, exhibiting induced resistance by unknown mechanisms. Therefore, the objective of this study was to identify the ultrastructural changes in viable cells of E. coli adapted to high concentrations (7000 ppm) of these antimicrobials, using transmission electron microscopy (TEM). After treatment with potassium sorbate, E. coli presented important morphological changes such as the separation of the cell membrane from the cytoplasm and cell wall, the appearance of a remarkable electronic light at the center of cells containing condensed deoxyribonucleic acid (DNA) molecules, as well as the appearance of small dense granules of electrons. Therefores, potassium sorbate induced more severe shape structural changes, presence of unusual structures and loss of integrity compared to viable cells adapted to sodium benzoate.
传统上,食品抗菌剂被用于延长滞后期或抑制微生物的生长;然而,已经证明,暴露于苯甲酸钠和山梨酸钾等亚致死浓度的抗菌剂,并逐渐增加剂量,可以使食物中感兴趣的微生物(如大肠杆菌)适应,表现出未知机制的诱导抗性。因此,本研究的目的是利用透射电子显微镜(TEM)鉴定大肠杆菌活细胞适应高浓度(7000 ppm)这些抗菌素的超微结构变化。经山梨酸钾处理后,大肠杆菌出现了重要的形态学变化,如细胞膜与细胞质和细胞壁分离,在含有浓缩脱氧核糖核酸(DNA)分子的细胞中心出现明显的电子光,以及出现小而致密的电子颗粒。因此,与适应苯甲酸钠的活细胞相比,山梨酸钾诱导更严重的形状结构变化,存在不寻常的结构和完整性丧失。
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引用次数: 1
Effect of Curcumin and Nano-curcumin on Reduce Aluminum Toxicity in Rats 姜黄素和纳米姜黄素对大鼠铝毒性的影响
Pub Date : 2019-10-09 DOI: 10.11648/j.ijfsb.20190403.12
R. M. Ibrahim, Fatma El Zahraa Ali Abd Elaal, S. Zaki
Aluminum is a ubiquitous toxic metal that mainly affects brain, bone, spleen, liver, kidney, hepatic hematopoietic system. This study investigated the effect of Curcumin and Curcumin Nanoparticles on reduced the toxicity of aluminum chloride in treated rats. Six groups of rats were used: (1) control; (2) curcumin-treated rats (15 mg curcumin /Kg BW; (3) Nano-curcumin -treated rats (15 mg Nano-curcumin /Kg BW); (4) aluminum chloride-treated rats (100 mg/kg BW); (5) AlCl3- curcumin-treated rats (100 mg AlCl3 and 15 mg curcumin/kg BW); (6) AlCl3- Nano-curcumin -treated rats (100 mg AlCl3 and 15 mg Nano-curcumin /kg BW). The treatment with AlCl3 alone caused significant (P≤ 0.05) increased in liver and kidney functions of rats, while the oral intake of curcumin and Nano-curcumin eliminate the harmful effect of AlCl3. On the same side, the treatment with AlCl3 alone significantly (P≤ 0.05) increase the free radical level and decreased the activities of antioxidant enzymes in plasma, while the treatment with curcumin and Nano-curcumin reduced this increased in free radicals and increased the activities of antioxidant enzymes. These results confirmed that the curcumin and Nano-curcumin reduced the toxicity effect of AlCl3 in rats; moreover, Nano-curcumin has a best biological and antioxidant activity than curcumin in healthy and AlCl3-treated rats.
铝是一种普遍存在的有毒金属,主要影响脑、骨、脾、肝、肾、肝造血系统。本研究探讨了姜黄素和姜黄素纳米颗粒对降低氯化铝中毒大鼠的作用。采用六组大鼠:(1)对照组;(2)姜黄素处理大鼠(15 mg姜黄素/Kg BW;(3)纳米姜黄素处理大鼠(15 mg纳米姜黄素/Kg BW);(4)氯化铝处理大鼠(100 mg/kg BW);(5) AlCl3-姜黄素处理大鼠(100 mg AlCl3和15 mg姜黄素/kg BW);(6) AlCl3-纳米姜黄素处理大鼠(100 mg AlCl3和15 mg纳米姜黄素/kg BW)。单用AlCl3治疗大鼠肝肾功能显著(P≤0.05)升高,而口服姜黄素和纳米姜黄素可消除AlCl3的有害作用。另一方面,AlCl3单独处理显著(P≤0.05)增加了血浆中自由基水平,降低了血浆中抗氧化酶的活性,而姜黄素和纳米姜黄素处理则降低了血浆中自由基的增加,提高了血浆中抗氧化酶的活性。这些结果证实姜黄素和纳米姜黄素降低了AlCl3对大鼠的毒性作用;此外,纳米姜黄素对健康大鼠和alcl3处理大鼠的生物活性和抗氧化活性均优于姜黄素。
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引用次数: 6
期刊
International Journal of Food Science and Biotechnology
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