International Journal of Polymeric Materials and Polymeric Biomaterials最新文献

{"title":"Hybrid nanoarchitecture of gelatin-modified silica-chitosan as an efficient delivery platform and functional role of crosslinking","authors":"Zahra Niazi, Mohsen Ashjari","doi":"10.1080/00914037.2023.2277237","DOIUrl":"https://doi.org/10.1080/00914037.2023.2277237","url":null,"abstract":"A novel hybrid of a quercetin-loaded silica-chitosan, modified by crosslinked gelatin-folate was developed in the current study as a pH-sensitive drug delivery system. The entrapment efficiency of ...","PeriodicalId":14203,"journal":{"name":"International Journal of Polymeric Materials and Polymeric Biomaterials","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138520469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeted co-delivery of paclitaxel and chrysin by hyaluronate/chitosan-coated polymeric nanoparticles for prostate cancer chemotherapy","authors":"Behzad Jamali, Sajjad Jamali, Sevil Vaghefi Moghaddam, Mohsen Firoozrai, Soodabeh Davaran, Fatemeh Abedi","doi":"10.1080/00914037.2023.2277219","DOIUrl":"https://doi.org/10.1080/00914037.2023.2277219","url":null,"abstract":"AbstractChemotherapy is one of the most common therapeutic approaches in most cancers like prostate cancer, which has always faced limitations. The purpose of the present study was to design and prepare the targeted polymeric nanoparticles for the co-delivery of Paclitaxel (PTX) and Chrysin (CHR) to prostate cancer cells to improve the PTX therapeutic efficacy. Through the current research, the surface modification of the PTX/CHR-loaded PCL-PEG-PCL nanoparticles with chitosan and hyaluronic acid (PTX/CHR-PCEC-CS/HA) was successfully performed through the physical adsorption process. SEM results showed that this polymeric NPs had a homogeneous spherical structure. The encapsulation efficiency was 78.6 and 93.28% for CHR and PTX, respectively. It is important to mention that the controlled drug-release behavior of the PTX/CHR-PCEC-CS/HA was also investigated. The results demonstrated that the dual drug-loaded PCEC-CS/HA NPs had a significant effect on reducing the survival of the cancer. Also, the results exhibited that the cytotoxicity of the dual drug-loaded polymeric NPs in the PC3 cell line is significantly higher than in the HUVEC cell line. Based on the findings, the targeted PTX/CHR-PCEC-CS/HA NPs could be employed as a suitable candidate for the effective treatment of the prostate cancer.Keywords: paclitaxelChrysinpolymeric nanoparticlesprostate cancertargeted drug delivery AcknowledgmentsThis project was fulfilled at the Faculty of Pharmacy, Tabriz University of Medical Science, Tabriz, Iran. We would like to thank the Faculty of Pharmacy, Tabriz University of Medical Science, Tabriz, Iran for their assistance in this research. Besides, the authors would like to thank the Drug Applied Research Center, Tabriz University of Medical Sciences cooperation in this project.Author contributionsAll authors have given approval to the final version of the manuscript.Disclosure statementNo potential conflict of interest was reported by the author(s).Data availability statementNo data was used for the research described in the article.","PeriodicalId":14203,"journal":{"name":"International Journal of Polymeric Materials and Polymeric Biomaterials","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135038666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polycaprolactone, polylactic acid, and nanohydroxyapatite scaffolds obtained by electrospinning and 3D printing for tissue engineering","authors":"Omar Alejandro González Rodríguez, Nancy Cecilia Ramírez Guerrero, Rocio Guadalupe Casañas Pimentel, Mónica Rosalia Jaime Fonseca, Eduardo San Martín Martínez","doi":"10.1080/00914037.2023.2277222","DOIUrl":"https://doi.org/10.1080/00914037.2023.2277222","url":null,"abstract":"AbstractThere is a deficit for bone tissue natural grafts that seek to be covered with synthetic substitutes. Scaffolds generated with 3D printing and electrospinning allow adequate mechanical properties maintaining a structure appropriate for cell growth. Here, a scaffold made up of three-dimensional (3D) printed PLA frameworks added with PCL/PLA/nHA nanofibers was manufactured. The framework showed mechanical properties similar to other reported bone substitutes, while the nanofibers showed diameters between 200 and 850 nm. Scaffolds were suitable for cell adhesion and proliferation when evaluated with fibroblasts, showing cell proliferation into the nanofiber network, a fundamental aspect in tissue engineering.Keywords: Nanofiberspolymeric scaffoldselectrospunpolylactic acidpolycaprolactonenanohydroxyapatitetissue engineeringbone AcknowledgmentsGonzalez Rodríguez Omar A. and Ramírez Guerrero Nancy acknowledge doctoral fellowship from CONACyT, N° 001406.Disclosure statementThe authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this article.CRediT authorship contribution statementGonzález Rodríguez Omar Alejandro: Conceptualization, Methodology, Ramírez Guerrero Nancy Cecilia: Methodology, Software, Casañas Pimentel Rocio Guadalupe: Visualization, Investigation, Jaime Fonseca Mónica Rosalia: Writing – Reviewing and Editing, San Martín Martínez Eduardo: Conceptualization, Data curation, Writing – Original draft preparation.Data availability statementData will be made available on request.Additional informationFundingThis work was supported by Consejo Nacional de Humanidades, Ciencias y Tecnologías (CONAHCYT), Mexico, Secretaría de Investigación y Posgrado, Instituto Politécnico Nacional.","PeriodicalId":14203,"journal":{"name":"International Journal of Polymeric Materials and Polymeric Biomaterials","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135474638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surface active polyesters based on N-substituted glutamic acid as promising materials for biomedical applications","authors":"Nataliia Fihurka, Ihor Tarnavchyk, Nataliya Nosova, Serhii Varvarenko, Iryna Dron, Dmytro Ostapiv, Vasyl Vlislo, Volodymyr Samaryk","doi":"10.1080/00914037.2023.2274591","DOIUrl":"https://doi.org/10.1080/00914037.2023.2274591","url":null,"abstract":"In the present work, N-substituted glutamic acid, polyethylene and polypropylene glycols have been used to design biocompatible copolyesters via Steglich reactions. Due to the presence of alternating hydrophilic and hydrophobic blocks in their structures, these copolyesters are able to form self-stabilized nanoparticle dispersions in aqueous media. The lipophilic core of these nanoparticles can solubilize poorly water-soluble compounds and release them into a model of lipids in a human body. Moreover, the obtained copolyesters possess no cytotoxic effects over a wide concentration range. Thus, we conclude that obtained copolyesters show significant promise for further development as drug delivery systems.","PeriodicalId":14203,"journal":{"name":"International Journal of Polymeric Materials and Polymeric Biomaterials","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135678815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design, optimization & characterization of niosomal & polymeric nanoparticles","authors":"Fatima Tariq, Muhammad Zaman, Muhammad Ahsan Waqar, Muhammad Asad Saeed, Rai Muhammad Sarfraz","doi":"10.1080/00914037.2023.2277235","DOIUrl":"https://doi.org/10.1080/00914037.2023.2277235","url":null,"abstract":"AbstractNiosomal and Polymeric-based nanoparticles offer advantages over conventional systems, such as targeted drug delivery and reduced toxicity. These nanoparticles are very promising due to their high drug loading capacity, stability, and ability to target specific cells or tissues. However, developing these nanoparticles presents challenges and requires careful selection of materials. These particles can deliver both hydrophilic and hydrophobic drugs and have applications in cancer therapy, gene therapy, and vaccination. This review aims to provide a comprehensive understanding of the current state of the art in the field of niosomal and polymeric nanoparticle design and optimization for efficient targeted drug delivery.Keywords: Cancer therapydrug loadingniosomal nanoparticlesoptimizationpolymeric nanoparticles Disclosure statementNo potential conflict of interest was reported by the author(s).","PeriodicalId":14203,"journal":{"name":"International Journal of Polymeric Materials and Polymeric Biomaterials","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135873617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A pH-sensitive magnetic hydrogel nanocomposite based on alginate for controlled release of methotrexate","authors":"Fahimeh Farshi Azhar, Aylin Ahmadinia, Hanieh Mousazadeh, Elnaz Kheirkhah","doi":"10.1080/00914037.2023.2274601","DOIUrl":"https://doi.org/10.1080/00914037.2023.2274601","url":null,"abstract":"","PeriodicalId":14203,"journal":{"name":"International Journal of Polymeric Materials and Polymeric Biomaterials","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136104046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and characterization of multi-targeted polymeric antibody-microparticle conjugates with controlled drug release","authors":"Lucia Fernandez, Shannon Oakes, John Cipullo, Cole Moros, Jenna Hofman, Noelle Comolli","doi":"10.1080/00914037.2023.2274609","DOIUrl":"https://doi.org/10.1080/00914037.2023.2274609","url":null,"abstract":"","PeriodicalId":14203,"journal":{"name":"International Journal of Polymeric Materials and Polymeric Biomaterials","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136318266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nano-drug delivery systems based on biodegradable polymers for the therapy of gynecological malignancies","authors":"Keer Jin, Hanxue Zhang, Yuwei Yang, Yan Gao","doi":"10.1080/00914037.2023.2263133","DOIUrl":"https://doi.org/10.1080/00914037.2023.2263133","url":null,"abstract":"AbstractGynecological malignancies are the main factors that seriously endanger the life and health of women worldwide. Chemotherapy is one of the traditional methods for the treatment of gynecological malignancies. Conventional chemotherapeutic drugs used in medicine have shortcomings, such as poor target tissue-specific distribution, high toxicity, and side effects. They are prone to problems such as tumor recurrence, invasion, metastasis, and drug resistance. The rapid development of nano-drug delivery systems achieves attenuation, potentiation, inhibition of metastasis, and resistance to drug resistance, bringing hope for the treatment of gynecological malignancies. This article briefly summarizes novel nano-drug delivery systems based on biodegradable polymers and their mediated treatment strategy for gynecological tumors to provide a theoretical basis for developing and clinically translating nano-drug delivery systems for gynecological malignancies.Keywords: Biodegradable polymersdrug-delivery systemgynecological malignancynanoparticles Additional informationFundingThis work was sponsored by the Natural Science Foundation of Liaoning Province (2020-ZLLH-41).","PeriodicalId":14203,"journal":{"name":"International Journal of Polymeric Materials and Polymeric Biomaterials","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135246061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kartogenin-loaded silk fibroin–chondroitin sulfate hybrid hydrogel with tailored β-sheet content: control release studies and biological activity","authors":"Maryam Farokhi, Atefeh Solouk, Hamid Mirzadeh, Heinz Redl, Andreas Teuschl-Woller","doi":"10.1080/00914037.2023.2255716","DOIUrl":"https://doi.org/10.1080/00914037.2023.2255716","url":null,"abstract":"AbstractSilk fibroin (SF)–chondroitin sulfate (CS)-hybrid hydrogels (HHGs) containing kartogenin (KGN) were synthesized by the induction of di-tyrosine bonds, using enzymatic crosslinking in SF/CS blend solution. Then, physical crosslinking was performed to optimize the HHG properties. The results showed that the increasing of the β-sheet content as side effect of physical crosslinking from 10% to 40% affects KGN accumulative release percentage almost three times. Biological investigations using C28/I2 human chondrocyte cell line showed that the presence of KGN, CS, and optimized β-sheets content improved cell supporting behavior of HHG. Finally, KGN loaded HHG might be a promising candidate for cartilage repair.Schematic representation of fabrication of the dual crosslinked hybrid hydrogel containing silk fibroin and chondroitin sulfate by enzymatic crosslinking and physical crosslinking method for kartogenin release. Enzymatic crosslinking: shaping di-tyrosine formation bond between silk fibroin phenol groups and locking physically chondroitin sulfate between silk fibroin β-sheets. Physical crosslinking with water and/or ethanol treatments end up in increased β-sheets content.Keywords: β-sheetkartogeninphysical crosslinkingrelease kineticssilk fibroin AcknowledgementsThe authors would like to thank Dr. Saeed Bahrami and Dr. Davood Sadeghi for their assistance in analyzing the biological results. The authors would like to express their gratitude to the office of Professional Laboratories and Technology Services in Amirkabir University of Technology (Tehran Polytechnic) for supporting this research under Grant Number 1401-0506.Author contributionsMaryam Farokhi: conceptualization, methodology, validation, formal analysis, investigation, writing – original draft, writing – review and editing, and visualization. Atefeh Solouk: conceptualization, methodology, resources, writing – review and editing, supervision, funding acquisition, and project administration. Hamid Mirzadeh: conceptualization, methodology, resources, supervision, project administration, and funding acquisition. Andreas Teuschl-Woller: conceptualization, supervision, methodology, resources, and writing-review and editing. Heinz Redl: conceptualization, methodology, resources, supervision, and project administration.Ethical approvalSince this is an in vitro study, no ethical declaration is required for this study.Disclosure statementThere is no conflict of interest associated with this research.Data availability statementNot applicable.Additional informationFundingThe authors would like to express their gratitude to the Office of Professional Laboratories and Technology Services in Amirkabir University of Technology (Tehran Polytechnic) for supporting this research under Grant Number 1401-0506.","PeriodicalId":14203,"journal":{"name":"International Journal of Polymeric Materials and Polymeric Biomaterials","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136059760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation of poly(acrylamide-co-Acrylonitrile) thermosensitivity microgel and control release of aspirin","authors":"S. Cai, X. Li, Shijie Pu, Xinyu Ma, Xianru He","doi":"10.1080/00914037.2022.2090355","DOIUrl":"https://doi.org/10.1080/00914037.2022.2090355","url":null,"abstract":"Abstract To extend the release time of drug carriers with the thermoresponsive behavior of upper critical solution temperature (UCST), P(AAm-co-AN) microgels are prepared by precipitation polymerization. It is found that the microgels exhibit the UCST-type response and the microgel shows swelling and disperses well when the temperature is higher than the critical temperature. Because the microgel can swell and shrink reversibly with the change in solution temperature, it can be used as a drug carrier. Compared with the micellar carrier, the microgel carrier’s structure is more stable and has a better sustained-release effect. Graphical Abstract","PeriodicalId":14203,"journal":{"name":"International Journal of Polymeric Materials and Polymeric Biomaterials","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81251663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}