{"title":"Synthesis and characterization of multi-targeted polymeric antibody-microparticle conjugates with controlled drug release","authors":"Lucia Fernandez, Shannon Oakes, John Cipullo, Cole Moros, Jenna Hofman, Noelle Comolli","doi":"10.1080/00914037.2023.2274609","DOIUrl":"https://doi.org/10.1080/00914037.2023.2274609","url":null,"abstract":"","PeriodicalId":14203,"journal":{"name":"International Journal of Polymeric Materials and Polymeric Biomaterials","volume":"3 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136318266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-29DOI: 10.1080/00914037.2023.2263133
Keer Jin, Hanxue Zhang, Yuwei Yang, Yan Gao
AbstractGynecological malignancies are the main factors that seriously endanger the life and health of women worldwide. Chemotherapy is one of the traditional methods for the treatment of gynecological malignancies. Conventional chemotherapeutic drugs used in medicine have shortcomings, such as poor target tissue-specific distribution, high toxicity, and side effects. They are prone to problems such as tumor recurrence, invasion, metastasis, and drug resistance. The rapid development of nano-drug delivery systems achieves attenuation, potentiation, inhibition of metastasis, and resistance to drug resistance, bringing hope for the treatment of gynecological malignancies. This article briefly summarizes novel nano-drug delivery systems based on biodegradable polymers and their mediated treatment strategy for gynecological tumors to provide a theoretical basis for developing and clinically translating nano-drug delivery systems for gynecological malignancies.Keywords: Biodegradable polymersdrug-delivery systemgynecological malignancynanoparticles Additional informationFundingThis work was sponsored by the Natural Science Foundation of Liaoning Province (2020-ZLLH-41).
{"title":"Nano-drug delivery systems based on biodegradable polymers for the therapy of gynecological malignancies","authors":"Keer Jin, Hanxue Zhang, Yuwei Yang, Yan Gao","doi":"10.1080/00914037.2023.2263133","DOIUrl":"https://doi.org/10.1080/00914037.2023.2263133","url":null,"abstract":"AbstractGynecological malignancies are the main factors that seriously endanger the life and health of women worldwide. Chemotherapy is one of the traditional methods for the treatment of gynecological malignancies. Conventional chemotherapeutic drugs used in medicine have shortcomings, such as poor target tissue-specific distribution, high toxicity, and side effects. They are prone to problems such as tumor recurrence, invasion, metastasis, and drug resistance. The rapid development of nano-drug delivery systems achieves attenuation, potentiation, inhibition of metastasis, and resistance to drug resistance, bringing hope for the treatment of gynecological malignancies. This article briefly summarizes novel nano-drug delivery systems based on biodegradable polymers and their mediated treatment strategy for gynecological tumors to provide a theoretical basis for developing and clinically translating nano-drug delivery systems for gynecological malignancies.Keywords: Biodegradable polymersdrug-delivery systemgynecological malignancynanoparticles Additional informationFundingThis work was sponsored by the Natural Science Foundation of Liaoning Province (2020-ZLLH-41).","PeriodicalId":14203,"journal":{"name":"International Journal of Polymeric Materials and Polymeric Biomaterials","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135246061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-22DOI: 10.1080/00914037.2023.2255716
Maryam Farokhi, Atefeh Solouk, Hamid Mirzadeh, Heinz Redl, Andreas Teuschl-Woller
AbstractSilk fibroin (SF)–chondroitin sulfate (CS)-hybrid hydrogels (HHGs) containing kartogenin (KGN) were synthesized by the induction of di-tyrosine bonds, using enzymatic crosslinking in SF/CS blend solution. Then, physical crosslinking was performed to optimize the HHG properties. The results showed that the increasing of the β-sheet content as side effect of physical crosslinking from 10% to 40% affects KGN accumulative release percentage almost three times. Biological investigations using C28/I2 human chondrocyte cell line showed that the presence of KGN, CS, and optimized β-sheets content improved cell supporting behavior of HHG. Finally, KGN loaded HHG might be a promising candidate for cartilage repair.Schematic representation of fabrication of the dual crosslinked hybrid hydrogel containing silk fibroin and chondroitin sulfate by enzymatic crosslinking and physical crosslinking method for kartogenin release. Enzymatic crosslinking: shaping di-tyrosine formation bond between silk fibroin phenol groups and locking physically chondroitin sulfate between silk fibroin β-sheets. Physical crosslinking with water and/or ethanol treatments end up in increased β-sheets content.Keywords: β-sheetkartogeninphysical crosslinkingrelease kineticssilk fibroin AcknowledgementsThe authors would like to thank Dr. Saeed Bahrami and Dr. Davood Sadeghi for their assistance in analyzing the biological results. The authors would like to express their gratitude to the office of Professional Laboratories and Technology Services in Amirkabir University of Technology (Tehran Polytechnic) for supporting this research under Grant Number 1401-0506.Author contributionsMaryam Farokhi: conceptualization, methodology, validation, formal analysis, investigation, writing – original draft, writing – review and editing, and visualization. Atefeh Solouk: conceptualization, methodology, resources, writing – review and editing, supervision, funding acquisition, and project administration. Hamid Mirzadeh: conceptualization, methodology, resources, supervision, project administration, and funding acquisition. Andreas Teuschl-Woller: conceptualization, supervision, methodology, resources, and writing-review and editing. Heinz Redl: conceptualization, methodology, resources, supervision, and project administration.Ethical approvalSince this is an in vitro study, no ethical declaration is required for this study.Disclosure statementThere is no conflict of interest associated with this research.Data availability statementNot applicable.Additional informationFundingThe authors would like to express their gratitude to the Office of Professional Laboratories and Technology Services in Amirkabir University of Technology (Tehran Polytechnic) for supporting this research under Grant Number 1401-0506.
{"title":"Kartogenin-loaded silk fibroin–chondroitin sulfate hybrid hydrogel with tailored β-sheet content: control release studies and biological activity","authors":"Maryam Farokhi, Atefeh Solouk, Hamid Mirzadeh, Heinz Redl, Andreas Teuschl-Woller","doi":"10.1080/00914037.2023.2255716","DOIUrl":"https://doi.org/10.1080/00914037.2023.2255716","url":null,"abstract":"AbstractSilk fibroin (SF)–chondroitin sulfate (CS)-hybrid hydrogels (HHGs) containing kartogenin (KGN) were synthesized by the induction of di-tyrosine bonds, using enzymatic crosslinking in SF/CS blend solution. Then, physical crosslinking was performed to optimize the HHG properties. The results showed that the increasing of the β-sheet content as side effect of physical crosslinking from 10% to 40% affects KGN accumulative release percentage almost three times. Biological investigations using C28/I2 human chondrocyte cell line showed that the presence of KGN, CS, and optimized β-sheets content improved cell supporting behavior of HHG. Finally, KGN loaded HHG might be a promising candidate for cartilage repair.Schematic representation of fabrication of the dual crosslinked hybrid hydrogel containing silk fibroin and chondroitin sulfate by enzymatic crosslinking and physical crosslinking method for kartogenin release. Enzymatic crosslinking: shaping di-tyrosine formation bond between silk fibroin phenol groups and locking physically chondroitin sulfate between silk fibroin β-sheets. Physical crosslinking with water and/or ethanol treatments end up in increased β-sheets content.Keywords: β-sheetkartogeninphysical crosslinkingrelease kineticssilk fibroin AcknowledgementsThe authors would like to thank Dr. Saeed Bahrami and Dr. Davood Sadeghi for their assistance in analyzing the biological results. The authors would like to express their gratitude to the office of Professional Laboratories and Technology Services in Amirkabir University of Technology (Tehran Polytechnic) for supporting this research under Grant Number 1401-0506.Author contributionsMaryam Farokhi: conceptualization, methodology, validation, formal analysis, investigation, writing – original draft, writing – review and editing, and visualization. Atefeh Solouk: conceptualization, methodology, resources, writing – review and editing, supervision, funding acquisition, and project administration. Hamid Mirzadeh: conceptualization, methodology, resources, supervision, project administration, and funding acquisition. Andreas Teuschl-Woller: conceptualization, supervision, methodology, resources, and writing-review and editing. Heinz Redl: conceptualization, methodology, resources, supervision, and project administration.Ethical approvalSince this is an in vitro study, no ethical declaration is required for this study.Disclosure statementThere is no conflict of interest associated with this research.Data availability statementNot applicable.Additional informationFundingThe authors would like to express their gratitude to the Office of Professional Laboratories and Technology Services in Amirkabir University of Technology (Tehran Polytechnic) for supporting this research under Grant Number 1401-0506.","PeriodicalId":14203,"journal":{"name":"International Journal of Polymeric Materials and Polymeric Biomaterials","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136059760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-22DOI: 10.1080/00914037.2022.2090355
S. Cai, X. Li, Shijie Pu, Xinyu Ma, Xianru He
Abstract To extend the release time of drug carriers with the thermoresponsive behavior of upper critical solution temperature (UCST), P(AAm-co-AN) microgels are prepared by precipitation polymerization. It is found that the microgels exhibit the UCST-type response and the microgel shows swelling and disperses well when the temperature is higher than the critical temperature. Because the microgel can swell and shrink reversibly with the change in solution temperature, it can be used as a drug carrier. Compared with the micellar carrier, the microgel carrier’s structure is more stable and has a better sustained-release effect. Graphical Abstract
{"title":"Preparation of poly(acrylamide-co-Acrylonitrile) thermosensitivity microgel and control release of aspirin","authors":"S. Cai, X. Li, Shijie Pu, Xinyu Ma, Xianru He","doi":"10.1080/00914037.2022.2090355","DOIUrl":"https://doi.org/10.1080/00914037.2022.2090355","url":null,"abstract":"Abstract To extend the release time of drug carriers with the thermoresponsive behavior of upper critical solution temperature (UCST), P(AAm-co-AN) microgels are prepared by precipitation polymerization. It is found that the microgels exhibit the UCST-type response and the microgel shows swelling and disperses well when the temperature is higher than the critical temperature. Because the microgel can swell and shrink reversibly with the change in solution temperature, it can be used as a drug carrier. Compared with the micellar carrier, the microgel carrier’s structure is more stable and has a better sustained-release effect. Graphical Abstract","PeriodicalId":14203,"journal":{"name":"International Journal of Polymeric Materials and Polymeric Biomaterials","volume":"27 1","pages":"1142 - 1150"},"PeriodicalIF":3.2,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81251663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-22DOI: 10.1080/00914037.2022.2082424
Alireza Kohan Hoosh Nejad, H. Ahmad panahi, E. Keshmirizadeh, Niloufar Torabi Fard
Abstract In this work, the magnetic metal-organic framework was synthesized based on a copper organic framework and Fe3O4 magnetic nanoparticles as a novel pH-responsive nanocarrier for oxaliplatin delivery. The magnetic metal-organic framework has been characterized by various analyses, such as Fourier transform infrared spectroscopy, thermogravimetric analysis, CHN analysis, and scanning electron microscopy. The application of the magnetic metal-organic framework as a pH-responsive nanocarrier for oxaliplatin is investigated through in vitro drug release experiments at simulated gastric (pH = 1.2) and simulated intestinal (pH = 7.4) fluids. About 35% of the oxaliplatin was released during 30 min in simulated gastric fluid, while 85% was released in simulated intestinal fluid in 9 h. The metal-organic framework indicated maximum adsorption capacity when the contact time at 10 min, the temperature of 25 °C, the initial concentration of the drug was 20 mg L−1, and pH = 7. Moreover, isotherm studies have shown that oxaliplatin adsorption via this magnetic metal-organic framework was of the Langmuir model. Graphical Abstract
{"title":"Fabrication of a pH-responsive drug delivery system based on the super-paramagnetic metal-organic framework for targeted delivery of oxaliplatin","authors":"Alireza Kohan Hoosh Nejad, H. Ahmad panahi, E. Keshmirizadeh, Niloufar Torabi Fard","doi":"10.1080/00914037.2022.2082424","DOIUrl":"https://doi.org/10.1080/00914037.2022.2082424","url":null,"abstract":"Abstract In this work, the magnetic metal-organic framework was synthesized based on a copper organic framework and Fe3O4 magnetic nanoparticles as a novel pH-responsive nanocarrier for oxaliplatin delivery. The magnetic metal-organic framework has been characterized by various analyses, such as Fourier transform infrared spectroscopy, thermogravimetric analysis, CHN analysis, and scanning electron microscopy. The application of the magnetic metal-organic framework as a pH-responsive nanocarrier for oxaliplatin is investigated through in vitro drug release experiments at simulated gastric (pH = 1.2) and simulated intestinal (pH = 7.4) fluids. About 35% of the oxaliplatin was released during 30 min in simulated gastric fluid, while 85% was released in simulated intestinal fluid in 9 h. The metal-organic framework indicated maximum adsorption capacity when the contact time at 10 min, the temperature of 25 °C, the initial concentration of the drug was 20 mg L−1, and pH = 7. Moreover, isotherm studies have shown that oxaliplatin adsorption via this magnetic metal-organic framework was of the Langmuir model. Graphical Abstract","PeriodicalId":14203,"journal":{"name":"International Journal of Polymeric Materials and Polymeric Biomaterials","volume":"147 1","pages":"1083 - 1092"},"PeriodicalIF":3.2,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75179705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-22DOI: 10.1080/00914037.2022.2082426
A. Subash, Abina Basanth, B. Kandasubramanian
Abstract The venture to fabricate potential and functional bone regeneration, annihilating the health complexities in conventional bone grafting, made Bone tissue engineering (BTE), which facilitates meticulous control of the spatial and temporal dissemination of cells and extracellular matrix (ECM), receive incredible consideration in the past few years. Ascribable to their exceptional properties, polymers have gotten significant attention as one of the prominent classes of biomaterials for BTE. The compatible mechanical properties, biocompatibility, bioactivity, and biodegradability of polyphosphazene/hydroxyapatite composite made them candidates for functional bone regeneration. This review demonstrates the synthesis, properties, and application of polyphosphazenes, hydroxyapatite, and composite biomaterial for BTE. Graphical Abstract
{"title":"Biodegradable polyphosphazene – hydroxyapatite composites for bone tissue engineering","authors":"A. Subash, Abina Basanth, B. Kandasubramanian","doi":"10.1080/00914037.2022.2082426","DOIUrl":"https://doi.org/10.1080/00914037.2022.2082426","url":null,"abstract":"Abstract The venture to fabricate potential and functional bone regeneration, annihilating the health complexities in conventional bone grafting, made Bone tissue engineering (BTE), which facilitates meticulous control of the spatial and temporal dissemination of cells and extracellular matrix (ECM), receive incredible consideration in the past few years. Ascribable to their exceptional properties, polymers have gotten significant attention as one of the prominent classes of biomaterials for BTE. The compatible mechanical properties, biocompatibility, bioactivity, and biodegradability of polyphosphazene/hydroxyapatite composite made them candidates for functional bone regeneration. This review demonstrates the synthesis, properties, and application of polyphosphazenes, hydroxyapatite, and composite biomaterial for BTE. Graphical Abstract","PeriodicalId":14203,"journal":{"name":"International Journal of Polymeric Materials and Polymeric Biomaterials","volume":"19 1","pages":"1093 - 1111"},"PeriodicalIF":3.2,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75131081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Polyelectrolyte multilayer (PEM) was developed through layer-by-layer (LbL) adsorption on sodium alginate on negatively charged lipid polymer hybrid nanoparticles (LPHNPs) for the delivery of Buspirone hydrochloride (BUH). The resultant BUH-LPHNPs (F2) showed a mean particle size of 166 ± 4.2 nm and zeta potential of −30.5 ± 1.52 mV. The BUH-LPHNPs were found to be stable and demonstrated controlled drug release kinetics. Further, the pharmacokinetic studies revealed a 3.29-fold rise in the oral bioavailability of formulation (F2) than BUH (pure). Thus, PEM fabricated through LbL technology could be explored for overcoming the bioavailability issue and targeted delivery for potential drug candidates.
{"title":"Design of layer-by-layer lipid-polymer hybrid nanoparticles to elicit oral bioavailability of buspirone hydrochloride","authors":"Pankaj Dangre, Kajal Sonawane, Kailas Moravkar, Anil Pethe, Shailesh Chalikwar, Vivek Borse","doi":"10.1080/00914037.2023.2255720","DOIUrl":"https://doi.org/10.1080/00914037.2023.2255720","url":null,"abstract":"<p><b>Abstract</b></p><p>Polyelectrolyte multilayer (PEM) was developed through layer-by-layer (LbL) adsorption on sodium alginate on negatively charged lipid polymer hybrid nanoparticles (LPHNPs) for the delivery of Buspirone hydrochloride (BUH). The resultant BUH-LPHNPs (F2) showed a mean particle size of 166 ± 4.2 nm and zeta potential of −30.5 ± 1.52 mV. The BUH-LPHNPs were found to be stable and demonstrated controlled drug release kinetics. Further, the pharmacokinetic studies revealed a 3.29-fold rise in the oral bioavailability of formulation (F2) than BUH (pure). Thus, PEM fabricated through LbL technology could be explored for overcoming the bioavailability issue and targeted delivery for potential drug candidates.</p>","PeriodicalId":14203,"journal":{"name":"International Journal of Polymeric Materials and Polymeric Biomaterials","volume":"2 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138520462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-04DOI: 10.1080/00914037.2023.2243369
Filipa Leal, V. Nirwan, Andreia M. Gonçalves, Nikolai Panitschewski, Eva Filová, Amir Fahmi, Pedro F. Costa
{"title":"Bio-inspired nanoporous scaffold: electrospun hybrid fibers based on self-assembled block copolymer mineralized with inorganic nanoparticles for bone tissue engineering","authors":"Filipa Leal, V. Nirwan, Andreia M. Gonçalves, Nikolai Panitschewski, Eva Filová, Amir Fahmi, Pedro F. Costa","doi":"10.1080/00914037.2023.2243369","DOIUrl":"https://doi.org/10.1080/00914037.2023.2243369","url":null,"abstract":"","PeriodicalId":14203,"journal":{"name":"International Journal of Polymeric Materials and Polymeric Biomaterials","volume":"52 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85721115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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