Pub Date : 2024-08-08DOI: 10.18203/2320-6012.ijrms20242268
Claudia F. Patiño-Orellana, Pablo X. Vázquez Donoso, Irlanda Ríos Andraca
Granuloma annulare (GA) is a benign granulomatous dermatosis of unknown etiology. In adults, the most common clinical form is the localized variant, characterized by a non-scaly, erythematous violaceous ring-shaped plaque, followed by the disseminated form that predominantly affects the trunk and limbs. It has been associated with diabetes mellitus, dyslipidemia, and autoimmune disorders. Herein, we present a 70-year-old patient who is overweight and has hepatic steatosis, with lesions of confirmed disseminated annular granuloma through histopathology and a subsequent diagnosis of type 2 diabetes.
{"title":"Disseminated annular granuloma: a rare dermatological manifestation of diabetes","authors":"Claudia F. Patiño-Orellana, Pablo X. Vázquez Donoso, Irlanda Ríos Andraca","doi":"10.18203/2320-6012.ijrms20242268","DOIUrl":"https://doi.org/10.18203/2320-6012.ijrms20242268","url":null,"abstract":"Granuloma annulare (GA) is a benign granulomatous dermatosis of unknown etiology. In adults, the most common clinical form is the localized variant, characterized by a non-scaly, erythematous violaceous ring-shaped plaque, followed by the disseminated form that predominantly affects the trunk and limbs. It has been associated with diabetes mellitus, dyslipidemia, and autoimmune disorders. Herein, we present a 70-year-old patient who is overweight and has hepatic steatosis, with lesions of confirmed disseminated annular granuloma through histopathology and a subsequent diagnosis of type 2 diabetes.","PeriodicalId":14210,"journal":{"name":"International Journal of Research in Medical Sciences","volume":"4 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141927812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-08DOI: 10.18203/2320-6012.ijrms20242270
Dalyir R. Garibay, Daniela T. Palacios, Carlos E. G. Córdova, Angelica M. S. Saldaña
Injuries to the hand are frequent, with an incidence of 15 per 1,000 individuals per year. They occur in one third of industrial accidents, in one in five traffic accidents, and they are the cause of one in every 3 cases of disability. The term “catastrophic or mangled hand” has traditionally been used to define lesions that affect all or almost all of the tissues and functional systems of the hand (the skin, bones and joints, the arteries and veins, sensory and motor nerves and the muscles and ligaments) usually accompanied by the amputation of fingers. The first surgery is crucial to ensure good vascularity to the salvaged tissue, prevent infection and achieve bony stabilization. Re-look surgery and definitive reconstruction can then follow. The complexity of these injuries has led to the development of various surgical treatments and vacuum assisted closure. In this case, the initial surgery was performed at another institution. Therefore, upon accepting the patient at our institution, we carried out initial surgical management, followed by the placement of a vacuum-assisted closure, considering the possibility of performing a definitive surgical procedure aimed at restoring the functional capacity of the hand.
{"title":"Vacuum assisted closure as adjuvant therapy for a mangled upper extremity injury","authors":"Dalyir R. Garibay, Daniela T. Palacios, Carlos E. G. Córdova, Angelica M. S. Saldaña","doi":"10.18203/2320-6012.ijrms20242270","DOIUrl":"https://doi.org/10.18203/2320-6012.ijrms20242270","url":null,"abstract":"Injuries to the hand are frequent, with an incidence of 15 per 1,000 individuals per year. They occur in one third of industrial accidents, in one in five traffic accidents, and they are the cause of one in every 3 cases of disability. The term “catastrophic or mangled hand” has traditionally been used to define lesions that affect all or almost all of the tissues and functional systems of the hand (the skin, bones and joints, the arteries and veins, sensory and motor nerves and the muscles and ligaments) usually accompanied by the amputation of fingers. The first surgery is crucial to ensure good vascularity to the salvaged tissue, prevent infection and achieve bony stabilization. Re-look surgery and definitive reconstruction can then follow. The complexity of these injuries has led to the development of various surgical treatments and vacuum assisted closure. In this case, the initial surgery was performed at another institution. Therefore, upon accepting the patient at our institution, we carried out initial surgical management, followed by the placement of a vacuum-assisted closure, considering the possibility of performing a definitive surgical procedure aimed at restoring the functional capacity of the hand.","PeriodicalId":14210,"journal":{"name":"International Journal of Research in Medical Sciences","volume":"12 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141927723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-08DOI: 10.18203/2320-6012.ijrms20242269
Sumit Bhatti, Thalapathy Ramkumar, Seemab Khan, Nikita Patil
Respiratory tract infections (RTIs) represent a substantial global health burden. Antibiotics, including macrolides like roxithromycin, are frequently prescribed to treat these infections. Roxithromycin exhibits bacteriostatic and bactericidal properties by disrupting bacterial protein synthesis. It has a better pharmacokinetic profile than erythromycin and demonstrates satisfactory tissue penetration and distribution. In addition to its antimicrobial action, roxithromycin displays anti-inflammatory properties, modulates neutrophilic actions, reduces pro-inflammatory cytokines, and inhibits mucus secretion and synthesis. These mechanisms contribute to its efficacy in treating a spectrum of RTIs, including sinusitis, pharyngotonsillitis, chronic rhinosinusitis, pneumonia, and bronchiectasis. Clinical studies have consistently demonstrated the effectiveness and tolerability of roxithromycin. Overall, roxithromycin offers a multifaceted approach to target both the microbial and inflammatory components of RTIs. Hence, this review aims to provide an overview of the pharmacokinetics and pharmacodynamics, as well as the efficacy and tolerability of roxithromycin in treating RTIs.
{"title":"The role of roxithromycin in the treatment of respiratory tract infections: a comprehensive overview","authors":"Sumit Bhatti, Thalapathy Ramkumar, Seemab Khan, Nikita Patil","doi":"10.18203/2320-6012.ijrms20242269","DOIUrl":"https://doi.org/10.18203/2320-6012.ijrms20242269","url":null,"abstract":"Respiratory tract infections (RTIs) represent a substantial global health burden. Antibiotics, including macrolides like roxithromycin, are frequently prescribed to treat these infections. Roxithromycin exhibits bacteriostatic and bactericidal properties by disrupting bacterial protein synthesis. It has a better pharmacokinetic profile than erythromycin and demonstrates satisfactory tissue penetration and distribution. In addition to its antimicrobial action, roxithromycin displays anti-inflammatory properties, modulates neutrophilic actions, reduces pro-inflammatory cytokines, and inhibits mucus secretion and synthesis. These mechanisms contribute to its efficacy in treating a spectrum of RTIs, including sinusitis, pharyngotonsillitis, chronic rhinosinusitis, pneumonia, and bronchiectasis. Clinical studies have consistently demonstrated the effectiveness and tolerability of roxithromycin. Overall, roxithromycin offers a multifaceted approach to target both the microbial and inflammatory components of RTIs. Hence, this review aims to provide an overview of the pharmacokinetics and pharmacodynamics, as well as the efficacy and tolerability of roxithromycin in treating RTIs.\u0000 ","PeriodicalId":14210,"journal":{"name":"International Journal of Research in Medical Sciences","volume":"19 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141927613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: The gallbladder, a critical component of the biliary system, plays a vital role in bile storage and digestion. Dysfunction in the gallbladder often results in gallstone formation, leading to significant healthcare burdens worldwide. Gallstone disease and gallbladder carcinoma are major health concerns, particularly in regions like India, where prevalence is high and poorly understood. Methods: This study aims to establish the normal baseline volume of the gallbladder using dual-energy computed tomography (DECT) and compare it with measurements obtained via ultrasound (USG). The cross-sectional study conducted at Era's Lucknow medical college and hospital involved 265 individuals aged 18-80 years with non-gallbladder-related abdominal conditions. Results: Final results showed the mean gallbladder volume to be 29.33±8.70 cm3 by DECT and 27.40±8.58 cm3 by USG, with DECT measurements being on average 1.93 cm3 higher. A significant association was found between gallbladder volume and obesity, but not gender. Conclusions: The findings suggest DECT provides slightly higher and potentially more accurate measurements of gallbladder volume compared to USG. These insights contribute to a better understanding of gallbladder physiology and the implications of its volume in various pathologies, emphasizing the need for further studies with larger sample sizes to validate these observations.
{"title":"Establishing normal gallbladder volume: a comparative study of dual energy computed tomography and ultrasound measurements in a North Indian population","authors":"Sachin Khanduri, Ambreen Fatima, Salma Khan, Zaara Khan, Vasundhara Sharma, Vibhor Dhingra, Tanya Bansal, Akshat Kumar Yadav, Mugheer Ahmad, Saddam Husain","doi":"10.18203/2320-6012.ijrms20241964","DOIUrl":"https://doi.org/10.18203/2320-6012.ijrms20241964","url":null,"abstract":"Background: The gallbladder, a critical component of the biliary system, plays a vital role in bile storage and digestion. Dysfunction in the gallbladder often results in gallstone formation, leading to significant healthcare burdens worldwide. Gallstone disease and gallbladder carcinoma are major health concerns, particularly in regions like India, where prevalence is high and poorly understood.\u0000Methods: This study aims to establish the normal baseline volume of the gallbladder using dual-energy computed tomography (DECT) and compare it with measurements obtained via ultrasound (USG). The cross-sectional study conducted at Era's Lucknow medical college and hospital involved 265 individuals aged 18-80 years with non-gallbladder-related abdominal conditions.\u0000Results: Final results showed the mean gallbladder volume to be 29.33±8.70 cm3 by DECT and 27.40±8.58 cm3 by USG, with DECT measurements being on average 1.93 cm3 higher. A significant association was found between gallbladder volume and obesity, but not gender.\u0000Conclusions: The findings suggest DECT provides slightly higher and potentially more accurate measurements of gallbladder volume compared to USG. These insights contribute to a better understanding of gallbladder physiology and the implications of its volume in various pathologies, emphasizing the need for further studies with larger sample sizes to validate these observations.","PeriodicalId":14210,"journal":{"name":"International Journal of Research in Medical Sciences","volume":"29 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141647804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-12DOI: 10.18203/2320-6012.ijrms20241959
Paresh Vhora, Mayur G. Baviskar, Riya B. Vakil
Background: Restoration of the skin barrier after wounding prevents infection, and minimises wound contraction, cosmetic disfigurement and volume depletion. Skin grafting represents an effective solution for large skin defects. Optimum care for donor-site wounds should promote wound healing cost-effectively while preventing complications like pain, infection, and scarring. Healthcare professionals use various dressings and topical agents, but there is no ideal dressing. In our study, we aim to compare the efficacy of chlorhexidine coated tulle gras (CTG) and polyurethane adhesive film (Opsite) in managing donor site wounds in split skin grafts. Methods: This study was conducted at the Department of Surgery, Lokmanya Tilak Municipal Medical College, a teaching hospital and tertiary care centre in Mumbai, from September 2012 to December 2014, following a prospective observational design, with a sample size of 50 patients. Results: The study subjects were predominantly in the 20-30 age group (36.0%) and mostly male (72.0%). The Opsite group reported significantly higher comfort scores (56.0%) compared to the CTG group (36.0%, p=0.002). Healing time was significantly shorter in the Opsite group (7.36±0.7 days) compared to the CTG group (9.52±1.39 days, p=0.001). Pain scores were significantly lower in the Opsite group at all observed times. Deviations like soakage and slippage were frequent in the Opsite group (76.0% and 56.0%, respectively). Conclusions: Opsite has advantages over CTG viz. faster healing and re-epithelization, decreased pain, and greater comfort. However, soakage and exudate formation are seen with Opsite.
{"title":"A comparative study of chlorhexidine-coated tulle gras versus polyurethane adhesive film for donor site wound dressing in split skin graft cases","authors":"Paresh Vhora, Mayur G. Baviskar, Riya B. Vakil","doi":"10.18203/2320-6012.ijrms20241959","DOIUrl":"https://doi.org/10.18203/2320-6012.ijrms20241959","url":null,"abstract":"Background: Restoration of the skin barrier after wounding prevents infection, and minimises wound contraction, cosmetic disfigurement and volume depletion. Skin grafting represents an effective solution for large skin defects. Optimum care for donor-site wounds should promote wound healing cost-effectively while preventing complications like pain, infection, and scarring. Healthcare professionals use various dressings and topical agents, but there is no ideal dressing. In our study, we aim to compare the efficacy of chlorhexidine coated tulle gras (CTG) and polyurethane adhesive film (Opsite) in managing donor site wounds in split skin grafts.\u0000Methods: This study was conducted at the Department of Surgery, Lokmanya Tilak Municipal Medical College, a teaching hospital and tertiary care centre in Mumbai, from September 2012 to December 2014, following a prospective observational design, with a sample size of 50 patients.\u0000Results: The study subjects were predominantly in the 20-30 age group (36.0%) and mostly male (72.0%). The Opsite group reported significantly higher comfort scores (56.0%) compared to the CTG group (36.0%, p=0.002). Healing time was significantly shorter in the Opsite group (7.36±0.7 days) compared to the CTG group (9.52±1.39 days, p=0.001). Pain scores were significantly lower in the Opsite group at all observed times. Deviations like soakage and slippage were frequent in the Opsite group (76.0% and 56.0%, respectively).\u0000Conclusions: Opsite has advantages over CTG viz. faster healing and re-epithelization, decreased pain, and greater comfort. However, soakage and exudate formation are seen with Opsite.","PeriodicalId":14210,"journal":{"name":"International Journal of Research in Medical Sciences","volume":"16 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141653515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-12DOI: 10.18203/2320-6012.ijrms20241960
Mukul Sharma, Saurabh Gupta, S. Verma, Lekha Sharma, Poonam Gupta, Kalu R. Sharma, N. Sahi
Background: Scrub typhus is a zoonotic infectious disease presenting commonly with acute febrile illness of variable severity and symptoms. It mimics other more prevalent tropical febrile illnesses such as dengue, malaria, and leptospirosis. Prevalence is high in and around Udaipur due to hilly terrains and agricultural farmlands. Multisystem involvement is common but liver dysfunction is a fatal comorbidity. Methods: In a retrospective observational study, we analyzed the clinical, biochemical, and demographic parameters of 85 patients of scrub typhus. The study population was distributed into four groups for abnormal liver chemistries based on American College of Gastroenterology (ACG) clinical guidelines: normal, borderline high, mild elevation, and moderate elevation. Results: Almost 80% of patients had abnormal liver chemistries including either serum bilirubin or transaminases. More than 30% of patients were categorized in group 2 and group 3 of the abnormal liver chemistries. Group 4 with moderate to severe liver dysfunction had 15.3% (n=13) patients. Thrombocytopenia and elevated blood urea and Creatinine were significantly seen in patients with both scrub typhus and liver dysfunction. Conclusions: Thus, in our study prevalence of hepatitis and jaundice with multiorgan failure in scrub typhus patients was significantly high. Timely identification of systemic complications and screening of liver chemistries on presentation is of utmost importance for better outcomes, among seriously ill patients.
{"title":"Clinical and biochemical profile of scrub typhus patients with emphasis on liver dysfunction in a tertiary care centre in South Rajasthan","authors":"Mukul Sharma, Saurabh Gupta, S. Verma, Lekha Sharma, Poonam Gupta, Kalu R. Sharma, N. Sahi","doi":"10.18203/2320-6012.ijrms20241960","DOIUrl":"https://doi.org/10.18203/2320-6012.ijrms20241960","url":null,"abstract":"Background: Scrub typhus is a zoonotic infectious disease presenting commonly with acute febrile illness of variable severity and symptoms. It mimics other more prevalent tropical febrile illnesses such as dengue, malaria, and leptospirosis. Prevalence is high in and around Udaipur due to hilly terrains and agricultural farmlands. Multisystem involvement is common but liver dysfunction is a fatal comorbidity.\u0000Methods: In a retrospective observational study, we analyzed the clinical, biochemical, and demographic parameters of 85 patients of scrub typhus. The study population was distributed into four groups for abnormal liver chemistries based on American College of Gastroenterology (ACG) clinical guidelines: normal, borderline high, mild elevation, and moderate elevation.\u0000Results: Almost 80% of patients had abnormal liver chemistries including either serum bilirubin or transaminases. More than 30% of patients were categorized in group 2 and group 3 of the abnormal liver chemistries. Group 4 with moderate to severe liver dysfunction had 15.3% (n=13) patients. Thrombocytopenia and elevated blood urea and Creatinine were significantly seen in patients with both scrub typhus and liver dysfunction.\u0000Conclusions: Thus, in our study prevalence of hepatitis and jaundice with multiorgan failure in scrub typhus patients was significantly high. Timely identification of systemic complications and screening of liver chemistries on presentation is of utmost importance for better outcomes, among seriously ill patients.","PeriodicalId":14210,"journal":{"name":"International Journal of Research in Medical Sciences","volume":"11 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141653654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-10DOI: 10.18203/2320-6012.ijrms20241958
Putu Kermawan, I. S. Yasa, I. M. Jawi, I. Suyasa, M. Karna
Osteoarthritis (OA) of the knee significantly disrupts daily activities and reduces quality of life due to pain. The primary treatment involves anti-inflammatories, which can cause stomach issues. Alternative therapies, including glucosamine, chondroitin, chitosan, and phytoestrogens, are being explored, but their effects need further study. While some benefits may be due to the placebo effect, researchers conducted a literature review to determine their actual benefits. A review of seven meta-analyses found that glucosamine and chondroitin can alleviate pain, reduce stiffness, improve function, and reduce joint space narrowing (JSN) in OA patients. Chitosan's use in intra-articular injections for OA has been studied in four observational studies and clinical trials on animals, but the effects of oral chitosan supplements remain unknown. A literature review on phytoestrogens in OA, particularly in post-menopausal women, identified four relevant studies. The review suggests that glucosamine, chondroitin, chitosan, and phytoestrogens have significant therapeutic benefits for OA, such as reducing pain (measured by VAS score), relieving stiffness, and improving functionality due to their anti-inflammatory and chondroprotective effects. Therefore, additional randomized controlled trials are needed to confirm their effectiveness in managing knee OA.
膝关节骨性关节炎（OA）会严重影响日常活动，并因疼痛而降低生活质量。主要的治疗方法是服用消炎药，但这可能会引起胃部不适。替代疗法包括葡萄糖胺、软骨素、壳聚糖和植物雌激素，目前正在探索中，但其效果还需要进一步研究。虽然有些益处可能是由于安慰剂效应造成的，但研究人员还是进行了文献综述，以确定它们的实际益处。对七项荟萃分析的综述发现，氨基葡萄糖和软骨素可减轻 OA 患者的疼痛、减轻僵硬感、改善功能并减少关节间隙狭窄（JSN）。壳聚糖在关节内注射治疗 OA 方面的应用已在四项观察性研究和动物临床试验中进行了研究，但口服壳聚糖补充剂的效果仍不清楚。一项关于植物雌激素对 OA（尤其是绝经后妇女）影响的文献综述确定了四项相关研究。综述表明，氨基葡萄糖、软骨素、壳聚糖和植物雌激素对 OA 有显著的治疗效果，如减轻疼痛（以 VAS 评分衡量）、缓解僵硬，以及由于其抗炎和保护软骨的作用而改善功能。因此，还需要更多的随机对照试验来证实它们在治疗膝关节 OA 方面的有效性。
{"title":"The pharmacological effects of glucosamine chondroitin, chitosan, and phytoestrogen on knee osteoarthritis","authors":"Putu Kermawan, I. S. Yasa, I. M. Jawi, I. Suyasa, M. Karna","doi":"10.18203/2320-6012.ijrms20241958","DOIUrl":"https://doi.org/10.18203/2320-6012.ijrms20241958","url":null,"abstract":"Osteoarthritis (OA) of the knee significantly disrupts daily activities and reduces quality of life due to pain. The primary treatment involves anti-inflammatories, which can cause stomach issues. Alternative therapies, including glucosamine, chondroitin, chitosan, and phytoestrogens, are being explored, but their effects need further study. While some benefits may be due to the placebo effect, researchers conducted a literature review to determine their actual benefits. A review of seven meta-analyses found that glucosamine and chondroitin can alleviate pain, reduce stiffness, improve function, and reduce joint space narrowing (JSN) in OA patients. Chitosan's use in intra-articular injections for OA has been studied in four observational studies and clinical trials on animals, but the effects of oral chitosan supplements remain unknown. A literature review on phytoestrogens in OA, particularly in post-menopausal women, identified four relevant studies. The review suggests that glucosamine, chondroitin, chitosan, and phytoestrogens have significant therapeutic benefits for OA, such as reducing pain (measured by VAS score), relieving stiffness, and improving functionality due to their anti-inflammatory and chondroprotective effects. Therefore, additional randomized controlled trials are needed to confirm their effectiveness in managing knee OA.","PeriodicalId":14210,"journal":{"name":"International Journal of Research in Medical Sciences","volume":"12 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141659174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-09DOI: 10.18203/2320-6012.ijrms20241957
Ankita Bhattacharjee, Jayanta Ray, Salilbindu Chakrabarti, Debasis Ray
Background: Magnesium sulphate (MgSO4) is the most popular anti-convulsant drug for treatment of eclampsia. Pritchard regimen is the most widely used regime worldwide where maintenance dose of MgSO4 is administered for 24-hour after delivery or last fit (whichever is later). As the duration of MgSO4 therapy increases, the incidence of adverse effects also increases. Therefore, the present study has been conducted to compare the maternal outcome with decreased duration of MgSO4 therapy for 12-hour with that of 24 hours for patients with eclampsia. Methods: It was an experimental study which was performed as a single centered, open labelled hospital based randomized control trial. It was conducted for 2 years (December 2019 to November 2021) among the patients of eclampsia admitted at department of obstetrics and gynaecology, AGMC and GBPH. Results: No cases of recurrent seizures in either group with additional benefit of lesser adverse effect of toxicity of MgSO4 in the 12-hour group. Conclusions: In the present study, it has been seen that 12-hour MgSO4 maintenance therapy is as efficacious as standard 24 hours therapy in controlling seizure as there was no case of recurrent seizure in either group.
{"title":"A randomized controlled trial to assess the efficacy of 12-hour magnesium sulphate therapy compared to 24-hour regimen on maternal outcome among patients with eclampsia admitted in a tertiary care centre","authors":"Ankita Bhattacharjee, Jayanta Ray, Salilbindu Chakrabarti, Debasis Ray","doi":"10.18203/2320-6012.ijrms20241957","DOIUrl":"https://doi.org/10.18203/2320-6012.ijrms20241957","url":null,"abstract":"Background: Magnesium sulphate (MgSO4) is the most popular anti-convulsant drug for treatment of eclampsia. Pritchard regimen is the most widely used regime worldwide where maintenance dose of MgSO4 is administered for 24-hour after delivery or last fit (whichever is later). As the duration of MgSO4 therapy increases, the incidence of adverse effects also increases. Therefore, the present study has been conducted to compare the maternal outcome with decreased duration of MgSO4 therapy for 12-hour with that of 24 hours for patients with eclampsia.\u0000Methods: It was an experimental study which was performed as a single centered, open labelled hospital based randomized control trial. It was conducted for 2 years (December 2019 to November 2021) among the patients of eclampsia admitted at department of obstetrics and gynaecology, AGMC and GBPH.\u0000Results: No cases of recurrent seizures in either group with additional benefit of lesser adverse effect of toxicity of MgSO4 in the 12-hour group.\u0000Conclusions: In the present study, it has been seen that 12-hour MgSO4 maintenance therapy is as efficacious as standard 24 hours therapy in controlling seizure as there was no case of recurrent seizure in either group.","PeriodicalId":14210,"journal":{"name":"International Journal of Research in Medical Sciences","volume":"110 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141665860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Many men with penile injuries opt out of medical treatment for ethical or psychological reasons, which means the true incidence is likely substantially lower than reported. Urgent medical attention is usually required for acute penile illnesses, which are rare but serious. A vascular, viral, or trauma-related event is usually to blame. Methods: The study was carried out at Narayana medical college in Nellore for a duration of two years, from January 2022 to April 2024.There were four groups vascular group with priapism and spontaneous penile gangrene (n=9) and those with penile fractures, degloving injuries, amputations, and entrapment (n=16) were part of the infected group, whereas patients with penile myiasis were part of the trauma group. The last group consisted of four patients who had paraphimosis. Results: The results showed that 60% of patients who had penile fractures within 6 hours presented for treatment. Every single patient has a torn tunica and one of them even has urethral involvement. Idiopathic causes 62.5% of the eight cases of priapism, and 37.5% of patients presented within six hours. Aspiration with intra-cavernous phenylephrine was the. If they fail to respond, employ the grey hack and water shunt techniques. Conclusions: The incidence of penile injuries is underreported; patients may appear to healthcare providers far later than necessary, and this is largely attributable to psychological and ethical factors, such as shame and fear. However, early and rapid management led to better outcomes.
{"title":"Penile emergencies: two years experience at our centre","authors":"Lakshmi Ramesh Muppirala, Yaswanth Kumar Gaddam, Udit Jain, Ravi Theja Bathalapalli","doi":"10.18203/2320-6012.ijrms20241948","DOIUrl":"https://doi.org/10.18203/2320-6012.ijrms20241948","url":null,"abstract":"Background: Many men with penile injuries opt out of medical treatment for ethical or psychological reasons, which means the true incidence is likely substantially lower than reported. Urgent medical attention is usually required for acute penile illnesses, which are rare but serious. A vascular, viral, or trauma-related event is usually to blame.\u0000Methods: The study was carried out at Narayana medical college in Nellore for a duration of two years, from January 2022 to April 2024.There were four groups vascular group with priapism and spontaneous penile gangrene (n=9) and those with penile fractures, degloving injuries, amputations, and entrapment (n=16) were part of the infected group, whereas patients with penile myiasis were part of the trauma group. The last group consisted of four patients who had paraphimosis.\u0000Results: The results showed that 60% of patients who had penile fractures within 6 hours presented for treatment. Every single patient has a torn tunica and one of them even has urethral involvement. Idiopathic causes 62.5% of the eight cases of priapism, and 37.5% of patients presented within six hours. Aspiration with intra-cavernous phenylephrine was the. If they fail to respond, employ the grey hack and water shunt techniques.\u0000Conclusions: The incidence of penile injuries is underreported; patients may appear to healthcare providers far later than necessary, and this is largely attributable to psychological and ethical factors, such as shame and fear. However, early and rapid management led to better outcomes.","PeriodicalId":14210,"journal":{"name":"International Journal of Research in Medical Sciences","volume":" 27","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141672317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-06DOI: 10.18203/2320-6012.ijrms20241947
Andrea Embarcadero Becerra, Karla Fabiola Grau Gutierrez Rubio, Luciano Ríos Lara Y. Lopez
Background: Breast reconstruction can have a significant impact on the physical, emotional and psychological well-being of patients undergoing mastectomy. The type and timing of breast reconstruction influence the satisfaction index of reconstructed patients. Methods: A retrospective examination was carried out on patient records from 2016 to 2024 at general hospital of Mexico. The analysis encompassed 210 patients who underwent breast reconstruction during this frame time. The BREAST-Q questionnaire was administered in March 2024 and at various intervals during each patient´s post-operative care. Patients were stratified according to multiple variables such as: oncological therapy, timing of reconstruction, type of reconstruction and educational attainment. Results: The average age of the participants was 50.3 years. In terms of reconstruction timing, 25.24% underwent immediate reconstruction, while 74.76% opted for delayed reconstruction. When it came to BMI, the average was 26.99 kg/m². Regarding the type of flap used for reconstruction, the majority (82.86%) had a latissimus dorsi flap. The overall demonstrated a mean psychosocial well-being scale score of 76±6.6. Conclusions: Breast reconstruction goes beyond physical restoration; it can profoundly impact a patient's emotional recovery, self-image, and quality of life. By addressing not only the physical changes but also the emotional and psychological aspects of breast cancer treatment, reconstruction plays a vital role in helping patients move forward with confidence, resilience, and a sense of empowerment. Regardless of when we first contact the patient, it is always worthwhile to provide her with information and the option of reconstruction.
{"title":"Outcomes in breast reconstruction using the BREAST-Q questionnaire at a third level hospital center in Mexico City","authors":"Andrea Embarcadero Becerra, Karla Fabiola Grau Gutierrez Rubio, Luciano Ríos Lara Y. Lopez","doi":"10.18203/2320-6012.ijrms20241947","DOIUrl":"https://doi.org/10.18203/2320-6012.ijrms20241947","url":null,"abstract":"Background: Breast reconstruction can have a significant impact on the physical, emotional and psychological well-being of patients undergoing mastectomy. The type and timing of breast reconstruction influence the satisfaction index of reconstructed patients.\u0000Methods: A retrospective examination was carried out on patient records from 2016 to 2024 at general hospital of Mexico. The analysis encompassed 210 patients who underwent breast reconstruction during this frame time. The BREAST-Q questionnaire was administered in March 2024 and at various intervals during each patient´s post-operative care. Patients were stratified according to multiple variables such as: oncological therapy, timing of reconstruction, type of reconstruction and educational attainment.\u0000Results: The average age of the participants was 50.3 years. In terms of reconstruction timing, 25.24% underwent immediate reconstruction, while 74.76% opted for delayed reconstruction. When it came to BMI, the average was 26.99 kg/m². Regarding the type of flap used for reconstruction, the majority (82.86%) had a latissimus dorsi flap. The overall demonstrated a mean psychosocial well-being scale score of 76±6.6.\u0000Conclusions: Breast reconstruction goes beyond physical restoration; it can profoundly impact a patient's emotional recovery, self-image, and quality of life. By addressing not only the physical changes but also the emotional and psychological aspects of breast cancer treatment, reconstruction plays a vital role in helping patients move forward with confidence, resilience, and a sense of empowerment. Regardless of when we first contact the patient, it is always worthwhile to provide her with information and the option of reconstruction.","PeriodicalId":14210,"journal":{"name":"International Journal of Research in Medical Sciences","volume":" 35","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141672589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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