{"title":"Traditional uses, phytochemistry and pharmacology review of 2 Vitex: diversifolia and doniana","authors":"Bangou Mindiédiba Jean, Meda Roland Nâg-Tiéro, Ouoba Yempabou Hermann, Nacoulma Odile Germaine","doi":"10.21276/ijrdpl.2278-0238.2019.8(2).29-36","DOIUrl":"https://doi.org/10.21276/ijrdpl.2278-0238.2019.8(2).29-36","url":null,"abstract":"","PeriodicalId":14211,"journal":{"name":"International Journal of Research and Development in Pharmacy & Life Sciences","volume":"63 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79083246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-15DOI: 10.21276/ijrdpl.2278-0238.2019.8(1).21-24
Ajai Kumar, K. Jawad, Seema Singh, Pradeep Sharma, Niranjan N. Singh, Mrinal Gupta
Iron deficiency anemia (IDA) is one of the most common nutritional disorders worldwide, affecting people of all ages in developed and developing countries. causes dimunition of various antioxidant enzymes like superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase. The objective of the study was to detect impact of iron supplementation in anaemic & non- anaemic pregnant subjects on oxidative stress. Patients are divided into two groups, Control groups (60 non-anemic pregnant women) & Study groups (60 anemic pregnant women). The blood sample (5 ml) was collected from different groups of subjects. In controls groups, a fall in catalase, superoxide dismutase, glutathione peroxidase and glutathione reductase were seen while lipid peroxidase was found to have increased significantly after iron therapy. In study group, and increment in all markers except lipid peroxidase was seen and the level of lipid peroxidase was decreased following iron supplementation which was statistically significant (p<0.001). it may be concluded that iron deficiency anaemia is associated with free radical generation and peroxidation of vital body molecules which implies increased risk for pregnant women.
{"title":"Role of oxidative stress after routine Iron supplementation in normal and anemic women during pregnancy: Central Indian scenario","authors":"Ajai Kumar, K. Jawad, Seema Singh, Pradeep Sharma, Niranjan N. Singh, Mrinal Gupta","doi":"10.21276/ijrdpl.2278-0238.2019.8(1).21-24","DOIUrl":"https://doi.org/10.21276/ijrdpl.2278-0238.2019.8(1).21-24","url":null,"abstract":"Iron deficiency anemia (IDA) is one of the most common nutritional disorders worldwide, affecting people of all ages in developed and developing countries. causes dimunition of various antioxidant enzymes like superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase. The objective of the study was to detect impact of iron supplementation in anaemic & non- anaemic pregnant subjects on oxidative stress. Patients are divided into two groups, Control groups (60 non-anemic pregnant women) & Study groups (60 anemic pregnant women). The blood sample (5 ml) was collected from different groups of subjects. In controls groups, a fall in catalase, superoxide dismutase, glutathione peroxidase and glutathione reductase were seen while lipid peroxidase was found to have increased significantly after iron therapy. In study group, and increment in all markers except lipid peroxidase was seen and the level of lipid peroxidase was decreased following iron supplementation which was statistically significant (p<0.001). it may be concluded that iron deficiency anaemia is associated with free radical generation and peroxidation of vital body molecules which implies increased risk for pregnant women.","PeriodicalId":14211,"journal":{"name":"International Journal of Research and Development in Pharmacy & Life Sciences","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76689695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.21276/ijrdpl.2278-0238.2019.8(1).15-20
Bharati Arali, Y AnandKumar, C MallikarjunaSetty
http://dx.doi.org/10.21276/IJRDPL.22780238.2019.8(1).15-20 ABSTRACT: Efavirenz is a widely prescribed anti-retroviral drug that belongs to BCS class II and exhibit low and variable oral bioavailability due to its poor aqueous solubility and it requires enhancement in solubility and dissolution rate for increasing its oral bioavailability. The aim of this study was to increase the solubility of Efavirenz (EFA) by complexing it with Hydroxypropyl-β-cyclodextrin (HPβCD). Solid binary systems were prepared by co-grinding and microwave irradiation methods. The interaction of EFA with HPβCD was evaluated by Phase solubility studies, in vitro dissolution studies and different analytical techniques including Fourier Transform Infrared Spectroscopy (FTIR) and Differential Scanning Calorimetry (DSC). The apparent stability constant revealed EFA with HPβCD produces 1:1 M stoichiometric complex. The host guest interactions studied by FTIR and DSC confirmed true inclusion of EFA with HPβCD at 1:2 M. The Dissolution rates of EFAHPβCD binary systems were faster when compared to physical mixture and pure drug. Overall the rank order of improvement in dissolution properties of Efavirenz with ratios is 1:2M > 1:1M and methods MW > CG > PM > Pure drug. One-way ANOVA suggest the DP60 and DE60 values were significantly higher (P<0.05) in solid binary systems prepared by microwave irradiation method when compared to co-grinding and its corresponding physical mixtures and pure drug.
{"title":"Characterization of Solid Binary Systems of Efavirenz and Hydroxypropyl-β-Cyclodextrin","authors":"Bharati Arali, Y AnandKumar, C MallikarjunaSetty","doi":"10.21276/ijrdpl.2278-0238.2019.8(1).15-20","DOIUrl":"https://doi.org/10.21276/ijrdpl.2278-0238.2019.8(1).15-20","url":null,"abstract":"http://dx.doi.org/10.21276/IJRDPL.22780238.2019.8(1).15-20 ABSTRACT: Efavirenz is a widely prescribed anti-retroviral drug that belongs to BCS class II and exhibit low and variable oral bioavailability due to its poor aqueous solubility and it requires enhancement in solubility and dissolution rate for increasing its oral bioavailability. The aim of this study was to increase the solubility of Efavirenz (EFA) by complexing it with Hydroxypropyl-β-cyclodextrin (HPβCD). Solid binary systems were prepared by co-grinding and microwave irradiation methods. The interaction of EFA with HPβCD was evaluated by Phase solubility studies, in vitro dissolution studies and different analytical techniques including Fourier Transform Infrared Spectroscopy (FTIR) and Differential Scanning Calorimetry (DSC). The apparent stability constant revealed EFA with HPβCD produces 1:1 M stoichiometric complex. The host guest interactions studied by FTIR and DSC confirmed true inclusion of EFA with HPβCD at 1:2 M. The Dissolution rates of EFAHPβCD binary systems were faster when compared to physical mixture and pure drug. Overall the rank order of improvement in dissolution properties of Efavirenz with ratios is 1:2M > 1:1M and methods MW > CG > PM > Pure drug. One-way ANOVA suggest the DP60 and DE60 values were significantly higher (P<0.05) in solid binary systems prepared by microwave irradiation method when compared to co-grinding and its corresponding physical mixtures and pure drug.","PeriodicalId":14211,"journal":{"name":"International Journal of Research and Development in Pharmacy & Life Sciences","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84620487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.21276/ijrdpl.2278-0238.2019.8(1).6-14
C. Ravishankar, Jaydeep Roy, Damodar Nayak Ammunje, J. Anbu, Mohammad Azamthulla
{"title":"A brief review on Pleiotropic effects of Pirfenidone - novel and ongoing outcomes","authors":"C. Ravishankar, Jaydeep Roy, Damodar Nayak Ammunje, J. Anbu, Mohammad Azamthulla","doi":"10.21276/ijrdpl.2278-0238.2019.8(1).6-14","DOIUrl":"https://doi.org/10.21276/ijrdpl.2278-0238.2019.8(1).6-14","url":null,"abstract":"","PeriodicalId":14211,"journal":{"name":"International Journal of Research and Development in Pharmacy & Life Sciences","volume":"72 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90381790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.21276/ijrdpl.2278-0238.2019.8(1).1-5
Shalini K. Sawhney
http://dx.doi.org/10.21276/IJRDPL.22780238.2019.8(1).1-5 ABSTRACT: Oxidative stress is produced by the reactive oxygen/nitrogen species (ROS/RNS) which involves mitochondrial dysfunction. Mitochondria is one of the main sources of oxidative stress, as it utilizes the oxygen for the energy production. Overproduction of ROS, results in oxidative stress, which injures the cell structures, lipids, proteins, and DNA. Various oxidative events implicated in many diseases is due to oxidative stress which include alteration in mitochondrial proteins, mitochondrial lipids and mitochondrial DNA, which in turn leads to damage nerve cells as they are metabolically very active. Reactive oxygen/nitrogen species at moderate concentrations also play roles in normal physiology of many processes like signalling pathways, induction of mitogenic response and in defence against infectious pathogens. Oxidative stress has been considered to be the main cause in the etiology of neurodegenerative diseases, which includes Parkinson’s disease (PD) and Alzheimer’s disease (AD). Recent research on the dysfunction and function of PD associated genes has provided new fundamental insights into biochemical pathways that are linked with the disease process This review includes source of free radical generation, mitochondrial dysfunction and the mechanism involved in neurodegenerative diseases which involves both PD as well as in AD. This makes the mitochondria, the main target of PD and AD research.
{"title":"Oxidative stress, Mitochondrial dysfunction and Neuro-degenerative diseases: A Review","authors":"Shalini K. Sawhney","doi":"10.21276/ijrdpl.2278-0238.2019.8(1).1-5","DOIUrl":"https://doi.org/10.21276/ijrdpl.2278-0238.2019.8(1).1-5","url":null,"abstract":"http://dx.doi.org/10.21276/IJRDPL.22780238.2019.8(1).1-5 ABSTRACT: Oxidative stress is produced by the reactive oxygen/nitrogen species (ROS/RNS) which involves mitochondrial dysfunction. Mitochondria is one of the main sources of oxidative stress, as it utilizes the oxygen for the energy production. Overproduction of ROS, results in oxidative stress, which injures the cell structures, lipids, proteins, and DNA. Various oxidative events implicated in many diseases is due to oxidative stress which include alteration in mitochondrial proteins, mitochondrial lipids and mitochondrial DNA, which in turn leads to damage nerve cells as they are metabolically very active. Reactive oxygen/nitrogen species at moderate concentrations also play roles in normal physiology of many processes like signalling pathways, induction of mitogenic response and in defence against infectious pathogens. Oxidative stress has been considered to be the main cause in the etiology of neurodegenerative diseases, which includes Parkinson’s disease (PD) and Alzheimer’s disease (AD). Recent research on the dysfunction and function of PD associated genes has provided new fundamental insights into biochemical pathways that are linked with the disease process This review includes source of free radical generation, mitochondrial dysfunction and the mechanism involved in neurodegenerative diseases which involves both PD as well as in AD. This makes the mitochondria, the main target of PD and AD research.","PeriodicalId":14211,"journal":{"name":"International Journal of Research and Development in Pharmacy & Life Sciences","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87605568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.21276/ijrdpl.2278-0238.2019.8(1).25-28
Mahalaxmi Iyer, Kaavya Jayaramayya, G. Bupesh, S. Kumaran
http://dx.doi.org/10.21276/IJRDPL.22780238.2019.8(1).25-28 ABSTRACT: Objectives: Ovarian cancer (OC) is a most dangerous gynecological cancer affecting women aged mostly in 50s and above due to its poor prognosis. mtDNA has been emerging as a prime hotspot candidate for the progression of OC. Thus, the objective of the present study was to investigate polymorphisms in COX – 2 gene in mtDNA by using PCR – RFLP. Methods: In the present study, detailed questionnaire and consent forms have been obtained from the OC patients and the age – matched controls. Blood samples from OC patients (n = 72) were collected from oncological clinics, and by population-based survey in South India. Control subjects (n=72) who had no history of tumors were selected and they were matched for age, sex and race. Peripheral blood was collected to detect polymorphism in the COX – 2 gene using PCR – RFLP. Result: In the present study, we found that OC patients with COX – 2 CC homozygous genotype showed higher risk for OC progression, whereas, the GG genotype in controls revealed its protection against the OC risk. Conclusion: In conclusion, our results suggests that, COX – 2 CC genotype may contribute to the development of OC pathogenesis. Though genetic polymorphism investigation was very limited to modulate the OC risks, the outcome of this study may help in future genotypic analysis. Thus, in future more genetic studies are warranted to prove that genotypic variation, mutations in COX – 2 would be a prime factor in Ovarian Carcinogenesis, and it can be used as candidate biomarker in treatment strategies.
{"title":"Identification of mitochondrial DNA profiling (COX 2) in ovarian cancer patients � A population-based study in South India","authors":"Mahalaxmi Iyer, Kaavya Jayaramayya, G. Bupesh, S. Kumaran","doi":"10.21276/ijrdpl.2278-0238.2019.8(1).25-28","DOIUrl":"https://doi.org/10.21276/ijrdpl.2278-0238.2019.8(1).25-28","url":null,"abstract":"http://dx.doi.org/10.21276/IJRDPL.22780238.2019.8(1).25-28 ABSTRACT: Objectives: Ovarian cancer (OC) is a most dangerous gynecological cancer affecting women aged mostly in 50s and above due to its poor prognosis. mtDNA has been emerging as a prime hotspot candidate for the progression of OC. Thus, the objective of the present study was to investigate polymorphisms in COX – 2 gene in mtDNA by using PCR – RFLP. Methods: In the present study, detailed questionnaire and consent forms have been obtained from the OC patients and the age – matched controls. Blood samples from OC patients (n = 72) were collected from oncological clinics, and by population-based survey in South India. Control subjects (n=72) who had no history of tumors were selected and they were matched for age, sex and race. Peripheral blood was collected to detect polymorphism in the COX – 2 gene using PCR – RFLP. Result: In the present study, we found that OC patients with COX – 2 CC homozygous genotype showed higher risk for OC progression, whereas, the GG genotype in controls revealed its protection against the OC risk. Conclusion: In conclusion, our results suggests that, COX – 2 CC genotype may contribute to the development of OC pathogenesis. Though genetic polymorphism investigation was very limited to modulate the OC risks, the outcome of this study may help in future genotypic analysis. Thus, in future more genetic studies are warranted to prove that genotypic variation, mutations in COX – 2 would be a prime factor in Ovarian Carcinogenesis, and it can be used as candidate biomarker in treatment strategies.","PeriodicalId":14211,"journal":{"name":"International Journal of Research and Development in Pharmacy & Life Sciences","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75532560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-11-01DOI: 10.21276/ijrdpl.2278-0238.2018.7(6).3164-3171
K. A. Khan, K. R. Reddy, C. Haranath, C. S. Reddy
http://dx.doi.org/10.21276/IJRDPL.22780238.2018.7(6).3164-3171 ABSTRACT: Urinary tract infections (UTI) are the most frequent bacterial infections affecting about 150 million people each year. The most common cause of infections is E. Coli. UTI’s are treated with short course antibiotics. Ofloxacin is a synthetic fluorinated carboxy quinolone that has a broad spectrum of activity against both gram positive & gram-negative bacteria. Multiple doses of ofloxacin are required to attain steady state concentration. The main objective of this study was to prepare and characterize ofloxacin microspheres to prolong the release rate so as to decrease the necessity of multiple dosing especially in patients with UTI. Nine formulations of ofloxacin microspheres were prepared using sodium alginate, sodium CMC and HPMC K 15M in various concentrations. Microspheres were prepared by ionic cross-linking method using calcium chloride as cross-linking agent. The prepared microspheres were evaluated for percentage yield, drug loading, entrapment efficiency, particle size analysis, swelling index, SEM studies, in-vitro dissolution, kinetics of drug release and ex-vivo studies. All the formulations exhibited satisfactory results in evaluations. DSC studies revealed no evidence of interaction between ofloxacin and polymers. Formulation F6 was selected as best formulation as it has good drug loading, percentage yield, entrapment efficiency and sustained the drug release for 8h. Results of ex-vivo studies indicate significant antimicrobial activity of microspheres. All the result demonstrated that ofloxacin microspheres can be effectively used in the treatment of urinary tract infections.
{"title":"Preparation and ex vivo evaluation of Microspheres for treatment of Urinary tract infections","authors":"K. A. Khan, K. R. Reddy, C. Haranath, C. S. Reddy","doi":"10.21276/ijrdpl.2278-0238.2018.7(6).3164-3171","DOIUrl":"https://doi.org/10.21276/ijrdpl.2278-0238.2018.7(6).3164-3171","url":null,"abstract":"http://dx.doi.org/10.21276/IJRDPL.22780238.2018.7(6).3164-3171 ABSTRACT: Urinary tract infections (UTI) are the most frequent bacterial infections affecting about 150 million people each year. The most common cause of infections is E. Coli. UTI’s are treated with short course antibiotics. Ofloxacin is a synthetic fluorinated carboxy quinolone that has a broad spectrum of activity against both gram positive & gram-negative bacteria. Multiple doses of ofloxacin are required to attain steady state concentration. The main objective of this study was to prepare and characterize ofloxacin microspheres to prolong the release rate so as to decrease the necessity of multiple dosing especially in patients with UTI. Nine formulations of ofloxacin microspheres were prepared using sodium alginate, sodium CMC and HPMC K 15M in various concentrations. Microspheres were prepared by ionic cross-linking method using calcium chloride as cross-linking agent. The prepared microspheres were evaluated for percentage yield, drug loading, entrapment efficiency, particle size analysis, swelling index, SEM studies, in-vitro dissolution, kinetics of drug release and ex-vivo studies. All the formulations exhibited satisfactory results in evaluations. DSC studies revealed no evidence of interaction between ofloxacin and polymers. Formulation F6 was selected as best formulation as it has good drug loading, percentage yield, entrapment efficiency and sustained the drug release for 8h. Results of ex-vivo studies indicate significant antimicrobial activity of microspheres. All the result demonstrated that ofloxacin microspheres can be effectively used in the treatment of urinary tract infections.","PeriodicalId":14211,"journal":{"name":"International Journal of Research and Development in Pharmacy & Life Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88624847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-11-01DOI: 10.21276/ijrdpl.2278-0238.2018.7(6).3155-3163
L. D, G. G, Purushothom A, P. A
Green Chemistry is considered as a significant tool to mitigate the use of hazardous chemicals. It encourages innovation and promotes the creation of products that are environmentally and economically sustainable. Synthetic chemicals which are used as internal indicators in acid- base titrations being hazardous can be substituted by using the natural indicators which gives results with the same accuracy. The accuracy of the observed results has been examined by performing titration between different acids and bases. Results supported this by less variation in the mean value and titre value from that of synthetic indicators. Thus, the use of natural indicators in the acid base titrations is statistically proved. The natural indicator prepared from flower petals is neither harmful to the environment nor it causes any health hazard. Therefore, in this work the use of natural indicator like petal extract is concluded more economical, simple, harmless, pollution free and inert.
{"title":"Green Chemistry: A study on acid-base indicator property of various flower pigments","authors":"L. D, G. G, Purushothom A, P. A","doi":"10.21276/ijrdpl.2278-0238.2018.7(6).3155-3163","DOIUrl":"https://doi.org/10.21276/ijrdpl.2278-0238.2018.7(6).3155-3163","url":null,"abstract":"Green Chemistry is considered as a significant tool to mitigate the use of hazardous chemicals. It encourages innovation and promotes the creation of products that are environmentally and economically sustainable. Synthetic chemicals which are used as internal indicators in acid- base titrations being hazardous can be substituted by using the natural indicators which gives results with the same accuracy. The accuracy of the observed results has been examined by performing titration between different acids and bases. Results supported this by less variation in the mean value and titre value from that of synthetic indicators. Thus, the use of natural indicators in the acid base titrations is statistically proved. The natural indicator prepared from flower petals is neither harmful to the environment nor it causes any health hazard. Therefore, in this work the use of natural indicator like petal extract is concluded more economical, simple, harmless, pollution free and inert.","PeriodicalId":14211,"journal":{"name":"International Journal of Research and Development in Pharmacy & Life Sciences","volume":"4 10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72750500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-11-01DOI: 10.21276/IJRDPL.2278-0238.2018.7(6).3172-3184
Venkateshwarlu Goli, O. Lanka, J. Tulasi
{"title":"An overview on Gastric Carcinoma with its recent statistical ranges throughout the world","authors":"Venkateshwarlu Goli, O. Lanka, J. Tulasi","doi":"10.21276/IJRDPL.2278-0238.2018.7(6).3172-3184","DOIUrl":"https://doi.org/10.21276/IJRDPL.2278-0238.2018.7(6).3172-3184","url":null,"abstract":"","PeriodicalId":14211,"journal":{"name":"International Journal of Research and Development in Pharmacy & Life Sciences","volume":"162 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86364148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-10-01DOI: 10.21276/IJRDPL.2278-0238.2018.7(5).3100-3103
K. Danao, P. Gangane, N. Mahajan, U. Mahajan
http://dx.doi.org/10.21276/IJRDPL.22780238.2018.7(5).3100-3103 ABSTRACT: Objective: In view of the present study, the object of the study was to formulate and evaluate nasal in situ gel contains Ondansetron hydrochloride. Methodology: Ondansetron hydrochloride loaded colloidal dispersion were prepared for nasal drug delivery using various polymers like carbopol (0.4%) and HPMC (1%) concentrations. The optimized formulation contains benzalkonium chloride as a preservative, sodium chloride as a tonicity adjuster, 0.5 M NaOH to maintain pH. The finished formulation was characterized for its clarity, pH, viscosity, drug content, net content, weight loss on storage, in vitro diffusion and in vitro bioadhesive strength. Result: Ondansetron hydrochloride was successfully formulated as a pH induced in situ gel for nasal administration and have potential to avoid first pass effect than oral route. Conclusion: The results of the study conclusively proved the suitability a nasal in situ gel of Ondansetron hydrochloride which was developed and formulated in this study is ideal for nasal administration for the treatment of antiemetic.
http://dx.doi.org/10.21276/IJRDPL.22780238.2018.7(5).3100-3103摘要:目的:针对本研究，制备含盐酸昂丹司琼鼻腔原位凝胶，并对其进行评价。方法:采用卡波波尔(0.4%)和HPMC(1%)等不同浓度的聚合物，制备盐酸昂丹司琼负载的胶状分散体，用于鼻腔给药。优化后的配方以苯扎氯铵为防腐剂，氯化钠为补强剂，0.5 M NaOH维持pH值。对优化后的配方进行了清晰度、pH值、粘度、药物含量、净含量、储存失重、体外扩散和体外生物粘附强度等指标的表征。结果:成功制备了盐酸昂丹司琼鼻腔用pH诱导原位凝胶，与口服给药相比，可避免首过效应。结论:本研究所研制的盐酸昂丹司琼鼻腔原位凝胶剂是鼻部给药治疗止吐的理想剂型。
{"title":"Formation and Development of Ondansetron Hydrochloride Nasal in situ gel","authors":"K. Danao, P. Gangane, N. Mahajan, U. Mahajan","doi":"10.21276/IJRDPL.2278-0238.2018.7(5).3100-3103","DOIUrl":"https://doi.org/10.21276/IJRDPL.2278-0238.2018.7(5).3100-3103","url":null,"abstract":"http://dx.doi.org/10.21276/IJRDPL.22780238.2018.7(5).3100-3103 ABSTRACT: Objective: In view of the present study, the object of the study was to formulate and evaluate nasal in situ gel contains Ondansetron hydrochloride. Methodology: Ondansetron hydrochloride loaded colloidal dispersion were prepared for nasal drug delivery using various polymers like carbopol (0.4%) and HPMC (1%) concentrations. The optimized formulation contains benzalkonium chloride as a preservative, sodium chloride as a tonicity adjuster, 0.5 M NaOH to maintain pH. The finished formulation was characterized for its clarity, pH, viscosity, drug content, net content, weight loss on storage, in vitro diffusion and in vitro bioadhesive strength. Result: Ondansetron hydrochloride was successfully formulated as a pH induced in situ gel for nasal administration and have potential to avoid first pass effect than oral route. Conclusion: The results of the study conclusively proved the suitability a nasal in situ gel of Ondansetron hydrochloride which was developed and formulated in this study is ideal for nasal administration for the treatment of antiemetic.","PeriodicalId":14211,"journal":{"name":"International Journal of Research and Development in Pharmacy & Life Sciences","volume":"58 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84190159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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