International Journal of Radiation Oncology Biology Physics最新文献

{"title":"Heat or Healing? Dealing With “Something That Looks Like Progression” of Brain Metastases","authors":"Frank A. Giordano M.D.","doi":"10.1016/j.ijrobp.2025.12.002","DOIUrl":"10.1016/j.ijrobp.2025.12.002","url":null,"abstract":"","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"124 3","pages":"Page 572"},"PeriodicalIF":6.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146102654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ahead of the Curve: Early Recognition and Effective Management of Radiation Necrosis","authors":"Christina Tsien MD, FRCP, FASTRO, Kevin Petrecca MD, PhD, FRSC","doi":"10.1016/j.ijrobp.2025.12.004","DOIUrl":"10.1016/j.ijrobp.2025.12.004","url":null,"abstract":"","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"124 3","pages":"Page 573"},"PeriodicalIF":6.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146102631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Reply to Oertel et al","authors":"Christina C. Huang MD, Chris R. Kelsey MD","doi":"10.1016/j.ijrobp.2025.11.055","DOIUrl":"10.1016/j.ijrobp.2025.11.055","url":null,"abstract":"","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"124 3","pages":"Pages 880-881"},"PeriodicalIF":6.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146102687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Too Hot to Handle? Navigating the Dilemma of Radiation Necrosis After Stereotactic Radiosurgery for Brain Metastases","authors":"Cas Stefaan Dejonckheere MD , Julian Philipp Layer MD","doi":"10.1016/j.ijrobp.2025.10.032","DOIUrl":"10.1016/j.ijrobp.2025.10.032","url":null,"abstract":"","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"124 3","pages":"Pages 570-571"},"PeriodicalIF":6.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146102854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous Integrated Dose Reduction Radiation Therapy Versus Conventional Fractionated Radiation Therapy With Chemotherapy for Limited-Stage Small Cell Lung Cancer in the Modern Treatment Era: A Phase 3, Randomized Clinical Trial (SDR-RT trial)","authors":"Tian-You Zhan MD ,&nbsp;Tao Zhang MD ,&nbsp;Wen-Qing Wang MD ,&nbsp;Lei Deng MD ,&nbsp;Yi-Rui Zhai MD ,&nbsp;Wen-Bin Yan MD ,&nbsp;Xin Wang MD ,&nbsp;Jian-Yang Wang MD ,&nbsp;Wen-Yang Liu MD ,&nbsp;Ming-Hui Li PhD ,&nbsp;Qin-Fu Feng MD ,&nbsp;Ji-Ma Lv MD ,&nbsp;Ze-Fen Xiao MD ,&nbsp;Dong-Fu Chen MD ,&nbsp;Jun-Ling Li MD ,&nbsp;Lv-Hua Wang MD ,&nbsp;Jun Liang MD ,&nbsp;Hong Ge MD ,&nbsp;Jian-Rong Dai PhD ,&nbsp;Kuo Men PhD ,&nbsp;Zong-Mei Zhou MD","doi":"10.1016/j.ijrobp.2025.09.058","DOIUrl":"10.1016/j.ijrobp.2025.09.058","url":null,"abstract":"<div><h3>Purpose</h3><div>Simultaneous integrated dose reduction (SDR) radiation therapy (SDR-RT) with a definitive dose to the gross tumor volume (GTV) and a relatively lower dose to the clinical target volume (CTV) might be beneficial in improving normal tissue sparing with low toxicity. We aimed to compare the efficacies of SDR-RT and conventional fractionated radiation therapy (CF-RT) for limited-stage small cell lung cancer (LS-SCLC).</div></div><div><h3>Methods and Materials</h3><div>Eligible patients with LS-SCLC were 1:1 randomized to receive CF-RT (60 Gy in 30 once-daily fractions over 6 weeks for both CTV and GTV) or SDR-RT (50 Gy for CTV and 60 Gy for GTV in 28 once-daily fractions over 5.5 weeks) along with 4 to 6 cycles of chemotherapy. The primary endpoint was progression-free survival (PFS) rate in the intention-to-treat population, whereas the secondary endpoints were overall survival rate and adverse event incidence.</div></div><div><h3>Results</h3><div>Between February 2017 and March 2023, 336 patients randomly received either SDR-RT (n = 165) or CF-RT (n = 171). Over a median follow-up of 56 months, the 2- and 5-year PFS rates in the intention-to-treat analysis were, respectively, 42.0% and 31.9% with SDR-RT, and 40.7% and 30.5% with CF-RT (<em>P</em> = .015 for noninferiority). The between-group differences in overall survival, locoregional PFS, and locoregional recurrence rates were nonsignificant. Compared with CF-RT, SDR-RT was associated with lower median values of V20 (21.0% vs 22.8%) and Dmean (12.1 vs 13.4 Gy) of the bilateral lungs (both <em>P</em> &lt; .001). Acute grade ≥3 toxicities and radiation pneumonitis incidence were lower with SDR-RT than that with CF-RT (54.5% vs 66.9%, <em>P</em> = .020; 2.4% vs 7.7%, <em>P</em> = .027).</div></div><div><h3>Conclusions</h3><div>Compared with CF-RT, SDR-RT led to similar survival and less acute adverse events. SDR-RT may be considered as a more protective approach for LS-SCLC treatment.</div></div>","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"124 3","pages":"Pages 692-701"},"PeriodicalIF":6.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145307933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Reply to Liu et al","authors":"Pierre Loap MD,&nbsp;Youlia Kirova MD","doi":"10.1016/j.ijrobp.2025.11.015","DOIUrl":"10.1016/j.ijrobp.2025.11.015","url":null,"abstract":"","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"124 3","pages":"Pages 877-878"},"PeriodicalIF":6.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146102526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating Tumor DNA in Human Papilloma Virus-Positive Oropharyngeal Squamous Cell Carcinoma—Are We Ready to Individualize Treatment?","authors":"Maria Gebre-Medhin MD, PhD ,&nbsp;Gabriel Adrian MD, PhD","doi":"10.1016/j.ijrobp.2025.10.013","DOIUrl":"10.1016/j.ijrobp.2025.10.013","url":null,"abstract":"","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"124 3","pages":"Pages 686-691"},"PeriodicalIF":6.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146102652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Regard to Duan et al","authors":"Masamune Noguchi MD,&nbsp;Kenta Nimura MD,&nbsp;Yutaro Koide MD, PhD","doi":"10.1016/j.ijrobp.2025.11.027","DOIUrl":"10.1016/j.ijrobp.2025.11.027","url":null,"abstract":"","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"124 3","pages":"Pages 881-882"},"PeriodicalIF":6.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146102688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Regard to Ka et al.","authors":"Matthias May MD, PhD,&nbsp;Oscar R. Brouwer MD, PhD,&nbsp;Laura Elst MD,&nbsp;Maarten Albersen MD, PhD","doi":"10.1016/j.ijrobp.2025.11.014","DOIUrl":"10.1016/j.ijrobp.2025.11.014","url":null,"abstract":"","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"124 3","pages":"Pages 868-869"},"PeriodicalIF":6.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146102404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Regard to Choi et al","authors":"Jean-Michel Hannoun-Levi MD, PhD,&nbsp;Cristina Gutierrez MD, PhD,&nbsp;Vratislav Strnad MD, PhD,&nbsp;Csaba Polgar MD, PhD","doi":"10.1016/j.ijrobp.2025.11.019","DOIUrl":"10.1016/j.ijrobp.2025.11.019","url":null,"abstract":"","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"124 3","pages":"Pages 874-875"},"PeriodicalIF":6.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146102406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}