International Journal of Radiation Oncology Biology Physics最新文献

{"title":"How to Improve the Implementation of New Radiotherapy Guidelines? Interests and Llimits of a National Training Workshop","authors":"G. LE QUELLENEC,&nbsp;X. Muracciole,&nbsp;A. Ducassou,&nbsp;C. Bartau,&nbsp;E. Jouglar,&nbsp;V. Martin,&nbsp;D. Mitrea,&nbsp;L. Duvergé,&nbsp;M. Jolnerovski,&nbsp;A. Jorand,&nbsp;J. Bouter,&nbsp;M. Cantaloube,&nbsp;G. Beldjoudi,&nbsp;L. Claude","doi":"10.1016/j.ijrobp.2024.11.048","DOIUrl":"10.1016/j.ijrobp.2024.11.048","url":null,"abstract":"<div><h3>Objectives</h3><div>The Inter-Ewing-1 trial is currently implemented in several countries with two randomized questions regarding radiotherapy: (1) dose escalation in definitive radiotherapy and (2) dose optimisation in post-operative radiotherapy. A prospective radiotherapy quality assurance (Quartet RTQA) is an essential part of the trial. Before opening the trial, the French Radiotherapy Group Society organised a delineation workshop to train the participants and evaluate the benefit on the delineation quality.</div></div><div><h3>Methods</h3><div>Before the workshop, all the participants were asked to delineate the target volumes of a benchmark case as recommended in the guidelines. During the workshop, the case and delineations were reviewed. A second delineation round was asked after the workshop.</div><div>Quantitative volume (Dice coefficient (DC)), dimension (Hausdorff distance (HD)), concordance and discordance index comparisons with the reference contours were made for GTVp_Pre, GTVp_Post, CTVp_Pre and CTVp_Post, before and after workshop.</div></div><div><h3>Results</h3><div>Eight centers provided both pre- and post-workshop delineations. Before the workshop, the median [Q25; Q75] DC for CTVp_Pre and CTVp_Post were 0.670 [0.629; 0.723] and 0.552 [0.428. 0.579] respectively versus 0.673 [0.656; 0.752] (Paired T-Test Welch, p=0.06) and 0.686 [0.574. 0.756] (Paired T-Test Welch, p=0.015) after the training.</div><div>Before the workshop, the median [Q25; Q75] HD for CTVp_Pre and CTVp_Post were 24.4 [19.0; 27.5] and 33.5 [27.1; 49.0] respectively versus 24.7 [19.8; 27.5] (Wilcoxon Signed Rank Test, p=0,830) and 22.8 [20.9; 35.6] (Wilcoxon Signed Rank Test, p=0.110) after the training. The results were similar for the GTVp_Pre and GTVp_Post and will be detailed at the congress.</div></div><div><h3>Conclusion</h3><div>The delineation of target volumes in ES remains difficult despite guidelines. These results confirm that training makes it possible to improve practices but this remains insufficient. This result highlights the importance of developing prospective RTQA to improve the quality of treatments.</div></div>","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"121 3","pages":"Page e13"},"PeriodicalIF":6.4,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143099109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BRCAness Identifies Synthetic Cytotoxicity Between Cisplatin and Radiation Therapy","authors":"Kerstin Borgmann PhD,&nbsp;David Krug MD","doi":"10.1016/j.ijrobp.2024.11.097","DOIUrl":"10.1016/j.ijrobp.2024.11.097","url":null,"abstract":"","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"121 3","pages":"Pages 780-782"},"PeriodicalIF":6.4,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143099122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pleuropulmonary Blastoma: Outcomes of Patients Treated with Curative Intent Protocols","authors":"S. David ,&nbsp;N. Khanna ,&nbsp;J. Manjali ,&nbsp;M. Prasad ,&nbsp;G. Chinnaswamy ,&nbsp;B. Parambil ,&nbsp;P. Panjwani ,&nbsp;M. Ramadwar ,&nbsp;S. Shah ,&nbsp;V. Patil ,&nbsp;S. Qureshi ,&nbsp;S. Laskar","doi":"10.1016/j.ijrobp.2024.11.036","DOIUrl":"10.1016/j.ijrobp.2024.11.036","url":null,"abstract":"<div><h3>Objectives</h3><div>Pleuropulmonary blastoma (PPB) is a rare and aggressive type of intrathoracic malignancy arising from pleuropulmonary mesenchyme predominantly seen in childhood. We evaluated the clinico-patho-radiological profile, treatment response, and overall outcomes for patients with PPB treated with curative intent protocols at the Tata Memorial Hospital (TMH).</div></div><div><h3>Methods</h3><div>All patients with histologically confirmed PPB were retrospectively analyzed.</div></div><div><h3>Results</h3><div>Between December 2004 to June 2023, 26 patients (15 males) with histologically proven PPB in the age group of 2 to 22 years (Median 4 years) were evaluated at TMH. Clinico-radiological and treatment details were available for 19 patients. The mean tumor size in this cohort was 11.45cm. The presence of pleural effusion and intrathoracic nodes was observed in 10 (53%) and 5 (26%) patients, respectively. All of them presented with locally extensive and type II/III disease.</div><div>Curative intent treatment was offered to 17 patients and 14 of them received upfront intensive multi-agent chemotherapy. Three patients underwent upfront surgery. Four out of fourteen (29%) patients progressed on induction chemotherapy and hence, did not undergo local treatment. Post neoadjuvant chemotherapy, out of the 9 patients, local treatment in the form of surgery was offered to 7 (64%) patients followed by adjuvant radiotherapy to 6 patients (38%), whereas 2 patients received definitive radiotherapy.</div><div>At the time of last follow up only 5 out of 17 (29%) patients were alive and disease free. All patients who had progressive disease on chemotherapy and did not receive local treatment died of the disease. Of the 12 patients receiving local treatment, 4 died of local relapse. The 2-year and 3-year overall survival of the entire cohort were 47% and 35% respectively.</div></div><div><h3>Conclusion</h3><div>PPB is associated with dismal outcomes. Patients responding to induction chemotherapy and receiving local treatment have better survival.</div></div>","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"121 3","pages":"Page e9"},"PeriodicalIF":6.4,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143102883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing Pediatric Radiation Therapy in sub-Saharan Africa: Report from a Pediatric Radiation Oncology Program in Nigeria","authors":"A. Joseph ,&nbsp;C. Agbakwuru ,&nbsp;A. Akinsete ,&nbsp;A. Oladipo ,&nbsp;N. Adedewe ,&nbsp;K. Badejoko ,&nbsp;M. Mangongolo ,&nbsp;A. Kotkat ,&nbsp;O. Fagbemide ,&nbsp;B. Saba","doi":"10.1016/j.ijrobp.2024.11.040","DOIUrl":"10.1016/j.ijrobp.2024.11.040","url":null,"abstract":"<div><h3>Objectives</h3><div>Pediatric radiation oncology is a rapidly emerging field in sub-Saharan Africa (SSA). There remain multiple opportunities for improvement despite ongoing advancements. This report documents the development, and implementation of a pediatric radiation oncology program in Nigeria.</div></div><div><h3>Methods</h3><div>A framework for the development and implementation relevant and feasible in light of local resources was designed. Preparation began in September 2022 and focused on three goals: Patients (improve outcomes and minimize side effects), Professionals (build capacity and multidisciplinary practice), and Protocols (local data and research). Key enabling factors were technology, training, and cohesion. Training, tumor board meetings, and weekly chart rounds, were initiated in collaboration with international experts. Equipment such as pediatric size immobilization devices were procured, and the unit was launched officially in September 2023.</div></div><div><h3>Results</h3><div>The pediatric radiation unit consists of two radiation oncologists, two medical physicists, three radiation therapy technologists, two oncology nurses, and trainees. The facility has three Linear Accelerators enabling the team to deliver conformal radiotherapy (IMRT/VMAT and SBRT). A retrospective review of pediatric cancer treatment at the facility revealed a total of 210 pediatric patients treated between 2020 and 2023 with an average age of 10.9 years. CNS tumors represented 28.1% of cases and 55.7% of patients received radiotherapy (RT). Among those who received RT, 54.7% had treatment breaks, 24.8% abandoned treatment and 75.2% completed their treatment. Recruitment of allied professionals such as physical or rehabilitation therapists specialized in pediatric oncology is a persisting challenge. Future efforts will focus on reducing treatment interruptions and abandonment.</div></div><div><h3>Conclusion</h3><div>Dedicated pediatric radiation oncology programs are an important step to improve pediatric cancer outcomes in SSA. Articulating goals, opportunities, challenges, solutions, and enabling factors as well as investment in capacity building, infrastructure, research, and collaboration are necessary for successful implementation.</div></div>","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"121 3","pages":"Pages e10-e11"},"PeriodicalIF":6.4,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143102886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Localized Hepatoblastoma in a Patient with Trisomy 18 Achieved Complete Remission with Radiation Therapy Alone","authors":"S. Chafe ,&nbsp;M. Rojas ,&nbsp;J. Zebak","doi":"10.1016/j.ijrobp.2024.11.060","DOIUrl":"10.1016/j.ijrobp.2024.11.060","url":null,"abstract":"<div><h3>Objectives</h3><div>Case report observing the response to palliative radiation therapy in a 19 month old with hepatoblastoma, Trisomy 18 and multiple comorbidities.</div></div><div><h3>Methods</h3><div>Radiation was delivered to the Liver mass. 3000 cGy was delivered in 10 daily fractions over 2 weeks.</div></div><div><h3>Results</h3><div>Complete resolution of the mass and AFP normalized by 4 months. The patient remains in remission 5 years post end of treatment.</div></div><div><h3>Conclusion</h3><div>Radiation should be a considered for patients with Hepatoblastoma who are not candidates for surgical resection and/or chemotherapy</div></div>","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"121 3","pages":"Page e17"},"PeriodicalIF":6.4,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143103238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-Reported Outcome Measures (PROMs) for Data Collection for Pediatric Radiotherapy","authors":"C. Dunlea ,&nbsp;C. Holborn ,&nbsp;C. Kambakara Gedara ,&nbsp;J. Gains ,&nbsp;M. Gaze ,&nbsp;P. Lim ,&nbsp;C. Soto ,&nbsp;Y. Chang","doi":"10.1016/j.ijrobp.2024.11.053","DOIUrl":"10.1016/j.ijrobp.2024.11.053","url":null,"abstract":"<div><h3>Objectives</h3><div>Critical review of the literature on the use of PROMs in data collection for radiotherapy (RT) treatment effects and the use of PROMs in a paediatric cohort of patients. To determine what PROM assessments are deemed effective in a radiation oncology setting and to investigate whether the assessments are in use for a younger cohort of patients.</div></div><div><h3>Methods</h3><div>A systematic search of literature from 1st of January 2008 to present day was conducted. Papers qualifying for critical evaluation were tabulated and thematic analysis was undertaken to identify emergent themes relating to:</div><div>What effects are being measured using PROMs</div><div>Which validated PROMs are being used?</div><div>Usability in a younger cohort of patients i.e. &lt;16 years old</div></div><div><h3>Results</h3><div>86 articles were identified for full text review and based on a pre-defined inclusion/exclusion criteria 30 articles were included for thematic analysis. Acute treatment side effects, depression, quality of life (QoL), and anxiety were the most prevalent RT treatment effects measured by PROMs. The most utilised PROMs in a radiation oncology setting include the Patient Reported Outcomes version of the CTCAE question library (PRO-CTCAE), the EORTC QoL Questionnaire Core (QLQ-C30) and the Hospital Anxiety and Depression Scale (HADs) respectively. Patients &lt;18 years were not included in any study population.</div></div><div><h3>Conclusion</h3><div>PROMs are deemed a useful method of data collection for health-related quality of life metrics, disease specific side effects and psychosocial wellbeing. The evidence of PROMs in clinical use for RT effects remains limited, and evidence is particularly scarce in study population age ranges &lt; 16 years. Further clinical evaluation is required on the use and standardisation of validated PROMs in RT data collection and to address the gap in evidence for the use of validated PROMs in younger patients undergoing treatment in a radiation oncology setting.</div></div>","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"121 3","pages":"Page e15"},"PeriodicalIF":6.4,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143103352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Outcomes Following Radiotherapy for Pediatric Salivary Gland Tumors","authors":"E. Augustin ,&nbsp;D. Indelicato ,&nbsp;J. Bradley ,&nbsp;I.V. E. Fortune ,&nbsp;S. Bradfield ,&nbsp;C. Morris ,&nbsp;R. Mailhot Vega","doi":"10.1016/j.ijrobp.2024.11.031","DOIUrl":"10.1016/j.ijrobp.2024.11.031","url":null,"abstract":"<div><h3>Objective</h3><div>In contrast to adult salivary gland tumors, our institutional guidelines in children utilize lower radiation doses, smaller target margins, and proton therapy (PT) to minimize radiation to the developing skull base anatomy. We also do not routinely recommend prophylactic nodal irradiation or elective neck dissection. Herein we report the outcomes of our age-based management approach.</div></div><div><h3>Methods</h3><div>We conducted a retrospective review of thirty-one consecutive pediatric patients (ages 6-21) with salivary gland tumors treated with PT at our institution between 2006-2023. The most common histologies were mucoepidermoid carcinoma (n=14), acinic cell carcinoma (n=5), and adenoid cystic carcinoma (n=5). Eight patients with radiographic lymphadenopathy underwent neck dissection prior to presentation, with selective dissections involving &lt; 4 nodal levels in 7/8 cases. The gross tumor volume (GTV) encompassed the residual tumor and tumor bed. Clinical target volume (CTV1), defined as GTV plus a 1 cm, received a dose of 50.4Gy. Prophylactic nodal irradiation was administered to only three patients as part of CTV1. CTV2 equaled the GTV and was treated to a median total dose of 64.8Gy (range, 61.2-70.8Gy). Toxicity data were graded using Common Terminology Criteria for Adverse Events Version 4.0.</div></div><div><h3>Results</h3><div>The median follow-up was 7.5 years (range, 1.2-15 years). Overall survival was 96% and local control was 94%. There were no nodal recurrences. Acute toxicities were limited to mucositis requiring opioids and transient grade 3 dermatitis. The most serious late toxicity involved the auditory system including 4 patients requiring hearing aids, 1 with chronic otitis media, 1 with osteonecrosis of the mastoid, and 1 with external canal stenosis. There was no grade 4 toxicity nor second malignancy.</div></div><div><h3>Conclusion</h3><div>Conservative neck management and moderate-dose PT delivered to small volumes resulted in excellent long-term disease control and limited toxicity in children with common salivary gland tumors.</div></div>","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"121 3","pages":"Page e8"},"PeriodicalIF":6.4,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143103478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Clinical Value of Psychological Intervention in Preparing Young Children with Neurological Tumors for Radiotherapy","authors":"X. Zhang ,&nbsp;F. Zhang ,&nbsp;M. Lai ,&nbsp;R. Luo ,&nbsp;R. Al","doi":"10.1016/j.ijrobp.2024.11.030","DOIUrl":"10.1016/j.ijrobp.2024.11.030","url":null,"abstract":"<div><h3>Objective</h3><div>To explore the clinical utility of psychological intervention during the radiotherapy of young children aged 3-5 years old with neuro-oncological tumors.</div></div><div><h3>Methods</h3><div>A total of 105 children aged 3-5 years with neuro-oncological diseases who underwent radiotherapy at Sanjiu Brain Hospital in Guangdong from January 2016 to December 2018 were selected. Fifty-two children who were admitted in 2016 served as the control group and received standard nursing care. Fifty-three children who were hospitalized from 2017 to 2018 were assigned to the experimental group and received psychological interventions in addition to regular care. The psychological interventions included evaluating medical fear ratings and providing pre-radiotherapy psychological interventions such as radiotherapy education, game simulation, systematic desensitization, and other techniques.</div></div><div><h3>Results</h3><div>The proportions of children who actively completed radiotherapy in the control and experimental groups were 30.77% and 86.79%, respectively. The percentage of children who cried was 28.85% in the control group and 3.77% in the experimental group. The experimental group had a considerably lower rate of sedative drug usage compared to the control group. Children in the experimental group had significantly higher compliance than those in the control group.</div></div><div><h3>Conclusion</h3><div>The implementation of psychological intervention could significantly reduce the need for sedative drugs during radiotherapy for children aged 3-5 years, thus preventing unnecessary expenditure of medical resources.</div></div>","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"121 3","pages":"Pages e7-e8"},"PeriodicalIF":6.4,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143103620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maximum Surgical Resection Followed by Radiation Therapy for the Management of Mucinous Adenocarcinoma of the Prostate","authors":"Krishnan R. Patel MD, MHS,&nbsp;William A. Hall MD","doi":"10.1016/j.ijrobp.2024.11.007","DOIUrl":"10.1016/j.ijrobp.2024.11.007","url":null,"abstract":"","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"121 3","pages":"Page 582"},"PeriodicalIF":6.4,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143171066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Sticky Situation: Mucinous Adenocarcinoma of the Prostate","authors":"Ariana Samsam ,&nbsp;Christopher W. Fleming MD","doi":"10.1016/j.ijrobp.2024.10.036","DOIUrl":"10.1016/j.ijrobp.2024.10.036","url":null,"abstract":"","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"121 3","pages":"Pages 580-581"},"PeriodicalIF":6.4,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143171068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}