Pub Date : 2022-01-01DOI: 10.31838/ijpr/2022.14.02.001
C. Suriyan, J. Martina, T. Sathishkumar, R. Ramesh, G. Prasannaraj
To evaluate the efficacy and safety of synthesized drug OUTBREAK, an Ayurvedic formulation for fever of viral origin in mild and moderate COVID19 positive patients. This is the prospective, randomized, multicentre, open label, parallel group interventional clinical endpoint study. Patients coming for the general outpatient department, were screened for viral fever by using the hematological, Biochemical and microbiological antibody assays. One Hundred patients who satisfied the selection criteria were enrolled in the study. Participants were randomized into 2 groups with 50 patients in each group. Patients were given standard treatment. In addition, Tab. OUTBREAK of Bageo Pharmaceuticals Pvt. Ltd., was administered to test groups. There is a highly significant improvement (P<0.001) in the subjects temperature, fever score, headache and SpO2 suggesting a good Analgesic and antipyretic activity of OUTBREAK. There is asignificant improvement in platelet count in the OUTBREAK treated group (P<0.01) when compared to the control group, proving its efficacy intreating thrombocytopenia. The improvement (P<0.01) in the random Sugar level in the OUTBREAK treated group depicts the anti-diabetic property of OUTBREAK.The improvement (P<0.01) in the WBC count in the OUTBREAK treated group depicts the antiviral property of OUTBREAK. The overall quality of life was better in OUTBREAK treated group compared to the control group. There were no serious adverse events reported. OUTBREAK is safe and efficacious in reversing thrombocytopenia and thus normalizing the platelet counts and relieving the clinical signs and symptoms (fever, headache and SpO2) of viral fever associated with thrombocytopenia and other cases of viral fever without thrombocytopenia. OUTBREAK is having good anti-viral, anti-pyretic and immuno-modulatory property.
{"title":"A randomized clinical study to evaluate the efficacy and safety of OUTBREAK in mild and moderate COVID19 positive patients","authors":"C. Suriyan, J. Martina, T. Sathishkumar, R. Ramesh, G. Prasannaraj","doi":"10.31838/ijpr/2022.14.02.001","DOIUrl":"https://doi.org/10.31838/ijpr/2022.14.02.001","url":null,"abstract":"To evaluate the efficacy and safety of synthesized drug OUTBREAK, an Ayurvedic formulation for fever of viral origin in mild and moderate COVID19 positive patients. This is the prospective, randomized, multicentre, open label, parallel group interventional clinical endpoint study. Patients coming for the general outpatient department, were screened for viral fever by using the hematological, Biochemical and microbiological antibody assays. One Hundred patients who satisfied the selection criteria were enrolled in the study. Participants were randomized into 2 groups with 50 patients in each group. Patients were given standard treatment. In addition, Tab. OUTBREAK of Bageo Pharmaceuticals Pvt. Ltd., was administered to test groups. There is a highly significant improvement (P<0.001) in the subjects temperature, fever score, headache and SpO2 suggesting a good Analgesic and antipyretic activity of OUTBREAK. There is asignificant improvement in platelet count in the OUTBREAK treated group (P<0.01) when compared to the control group, proving its efficacy intreating thrombocytopenia. The improvement (P<0.01) in the random Sugar level in the OUTBREAK treated group depicts the anti-diabetic property of OUTBREAK.The improvement (P<0.01) in the WBC count in the OUTBREAK treated group depicts the antiviral property of OUTBREAK. The overall quality of life was better in OUTBREAK treated group compared to the control group. There were no serious adverse events reported. OUTBREAK is safe and efficacious in reversing thrombocytopenia and thus normalizing the platelet counts and relieving the clinical signs and symptoms (fever, headache and SpO2) of viral fever associated with thrombocytopenia and other cases of viral fever without thrombocytopenia. OUTBREAK is having good anti-viral, anti-pyretic and immuno-modulatory property.","PeriodicalId":14220,"journal":{"name":"International Journal of Pharmaceutical Research","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76257715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.31838/ijpr/2022.14.01.005
{"title":"Antidiabetic Activity Of Selenicereus Undatus (Haw). Fruit Extract Against Alloxan Induced Diabetic Mice","authors":"","doi":"10.31838/ijpr/2022.14.01.005","DOIUrl":"https://doi.org/10.31838/ijpr/2022.14.01.005","url":null,"abstract":"","PeriodicalId":14220,"journal":{"name":"International Journal of Pharmaceutical Research","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72933285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.31838/ijpr/2022.14.02.002
{"title":"Evaluation of the lethality of fractional extracts of Artemisia vulgaris on the Artemia salina larvae.","authors":"","doi":"10.31838/ijpr/2022.14.02.002","DOIUrl":"https://doi.org/10.31838/ijpr/2022.14.02.002","url":null,"abstract":"","PeriodicalId":14220,"journal":{"name":"International Journal of Pharmaceutical Research","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85220460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.31838/ijpr/2022.14.01.014
{"title":"Antidiabetic activity of alcoholic extract of Momordica charantia and Murraya koenigii in alloxan induced albino rat","authors":"","doi":"10.31838/ijpr/2022.14.01.014","DOIUrl":"https://doi.org/10.31838/ijpr/2022.14.01.014","url":null,"abstract":"","PeriodicalId":14220,"journal":{"name":"International Journal of Pharmaceutical Research","volume":"72 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84152191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.31838/ijpr/2022.14.02.003
{"title":"Mechanistic Approach Of Topoisomerase Ii ? Inhibitors For Anticancer Activity: A Review","authors":"","doi":"10.31838/ijpr/2022.14.02.003","DOIUrl":"https://doi.org/10.31838/ijpr/2022.14.02.003","url":null,"abstract":"","PeriodicalId":14220,"journal":{"name":"International Journal of Pharmaceutical Research","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81031666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.31838/ijpr/2022.14.01.009
{"title":"Uv-Spectrophotomeric Method Development And Validation Of Synthesized Benzimidazole Derivative.","authors":"","doi":"10.31838/ijpr/2022.14.01.009","DOIUrl":"https://doi.org/10.31838/ijpr/2022.14.01.009","url":null,"abstract":"","PeriodicalId":14220,"journal":{"name":"International Journal of Pharmaceutical Research","volume":"69 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84456795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.31838/ijpr/2022.14.01.024
{"title":"The Effect of Bergenia ligulata WALL in prediabetes: A randomized single-blind placebo-controlled study.","authors":"","doi":"10.31838/ijpr/2022.14.01.024","DOIUrl":"https://doi.org/10.31838/ijpr/2022.14.01.024","url":null,"abstract":"","PeriodicalId":14220,"journal":{"name":"International Journal of Pharmaceutical Research","volume":"114 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80781773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.31838/ijpr/2022.14.01.004
{"title":"Urtica dioica L.: A Review of its Nutritional and Pharmacological Activities","authors":"","doi":"10.31838/ijpr/2022.14.01.004","DOIUrl":"https://doi.org/10.31838/ijpr/2022.14.01.004","url":null,"abstract":"","PeriodicalId":14220,"journal":{"name":"International Journal of Pharmaceutical Research","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74505729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.31838/ijpr/2022.14.01.001
{"title":"The Effect of Green Tea Leaves (Camellia Sinensis) Ethanol Extract Administration on The Ephitelium Thickness of Seminiferous Tubules and Number of Sertoli Cell in Mice (Mus Musculus) Exposed to 2,3,7,8-Tetrachlorodibenzo-P-Dioxin (TCDD)","authors":"","doi":"10.31838/ijpr/2022.14.01.001","DOIUrl":"https://doi.org/10.31838/ijpr/2022.14.01.001","url":null,"abstract":"","PeriodicalId":14220,"journal":{"name":"International Journal of Pharmaceutical Research","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90489251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.31838/ijpr/2022.14.01.003
R. Jadhav, S. Patil, P. Deolekar, Pamelle Yadav, K. Dongerkery
Introduction: The infection caused by COVID-19 ranges from mild to moderate infection, but it can also cause severe infection and death in some people mostly in people who are old, or immunocompromisedSARS-CoV-2 has shown evidence of having higher capacity of binding to human cells and can settle in upper and lower portion of the respiratory tract it being the two important hotspots. Symptoms localized to the upper respiratory tract are mild which usually includes anosmia/hyposmia, ageusia/ dysgeusia, rhinitis along with sore throat. Material and methods: This study included individuals who were diagnosed with COVID-19 having mild symptoms of the disease which could be managed at their homes.Random assignment (50/50 chance) of subjects was done into two groups (A and B) for this study. Participants in group A were asked to perform the nasal washing and gargling with salt water up to 10 times a day for 14 days or until they felt better.Results:The leading cause for hospitalization for 15 (53.57%) people was that the oxygen saturation fell to below 93. Some scores compared between the two groups showed significant results in parameters of headache, postnasal drip, anosmia, sinusitis, sore throat, body ache, dry cough by unpaired two tailed P test. The age groups of 26 to 35, and 56 to 65 had comparatively higher values of adherence as compared to different age groups.Conclusion:The study demonstrates the hypothesis that nasal irrigation and saline gargling can have promising results to reduce the severity of COVID-19 infection when initiated within 24 hours of a positive test.
{"title":"A comparative study to evaluate the use of saline nasal lavage and gargling in patients with Covid-19 infection.","authors":"R. Jadhav, S. Patil, P. Deolekar, Pamelle Yadav, K. Dongerkery","doi":"10.31838/ijpr/2022.14.01.003","DOIUrl":"https://doi.org/10.31838/ijpr/2022.14.01.003","url":null,"abstract":"Introduction: The infection caused by COVID-19 ranges from mild to moderate infection, but it can also cause severe infection and death in some people mostly in people who are old, or immunocompromisedSARS-CoV-2 has shown evidence of having higher capacity of binding to human cells and can settle in upper and lower portion of the respiratory tract it being the two important hotspots. Symptoms localized to the upper respiratory tract are mild which usually includes anosmia/hyposmia, ageusia/ dysgeusia, rhinitis along with sore throat. Material and methods: This study included individuals who were diagnosed with COVID-19 having mild symptoms of the disease which could be managed at their homes.Random assignment (50/50 chance) of subjects was done into two groups (A and B) for this study. Participants in group A were asked to perform the nasal washing and gargling with salt water up to 10 times a day for 14 days or until they felt better.Results:The leading cause for hospitalization for 15 (53.57%) people was that the oxygen saturation fell to below 93. Some scores compared between the two groups showed significant results in parameters of headache, postnasal drip, anosmia, sinusitis, sore throat, body ache, dry cough by unpaired two tailed P test. The age groups of 26 to 35, and 56 to 65 had comparatively higher values of adherence as compared to different age groups.Conclusion:The study demonstrates the hypothesis that nasal irrigation and saline gargling can have promising results to reduce the severity of COVID-19 infection when initiated within 24 hours of a positive test.","PeriodicalId":14220,"journal":{"name":"International Journal of Pharmaceutical Research","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87546305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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