Pub Date : 2022-01-01DOI: 10.31838/ijpr/2022.14.01.016
{"title":"Action of Ultra-low Dose Medicine on Oxidative Stress and Cell Stiffness of Microglial Cells In Vitro with Actin Filaments Reorganization","authors":"","doi":"10.31838/ijpr/2022.14.01.016","DOIUrl":"https://doi.org/10.31838/ijpr/2022.14.01.016","url":null,"abstract":"","PeriodicalId":14220,"journal":{"name":"International Journal of Pharmaceutical Research","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90732075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.31838/ijpr/2022.14.01.007
{"title":"Recent Progress And Biomedical Applications Of Metal Oxide Based Biodegradable Polymer Nanocomposites –An Overview","authors":"","doi":"10.31838/ijpr/2022.14.01.007","DOIUrl":"https://doi.org/10.31838/ijpr/2022.14.01.007","url":null,"abstract":"","PeriodicalId":14220,"journal":{"name":"International Journal of Pharmaceutical Research","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82105888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.31838/ijpr/2022.14.01.006
{"title":"Enhancing and improvement of plant growth by using Bacillus isolate GK15 from rhizosphere soil","authors":"","doi":"10.31838/ijpr/2022.14.01.006","DOIUrl":"https://doi.org/10.31838/ijpr/2022.14.01.006","url":null,"abstract":"","PeriodicalId":14220,"journal":{"name":"International Journal of Pharmaceutical Research","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78922535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-30DOI: 10.31838/ijpr/2021.13.03.020
M. Avijit, Singh Ashini
Metformin is a biguanide that has been used extensively worldwide for the treatment of type II diabetes mellitus. It improves glycaemic control by enhancing insulin sensitivity in liver and muscle. An advantage of metformin treatment is the tendency of weight reduction and the absence of significant hypoglycaemia; blood glucose levels are reduced only to normal as it does not stimulate insulin secretion. Metformin also has a beneficial effect on several cardiovascular risk factors including dyslipidemia, elevated plasminogen activator inhibitor 1 levels, other fibrinolytic abnormalities, hyperinsulinemia, and insulin resistance. Metformin enhances muscle and adipocyte insulin receptor number and/or affinity, increases insulin receptor tyrosine kinase activity, stimulates glucose transport and glycogen synthesis, and reduces both hepatic gluconeogenesis and glycogenolysis. The disadvantages are confined to the gastro-intestinal side effects and the potential risk of vitamin B 12 and folic acid deficiency during long-term use. These side effects can be minimized by slow titration and consumption with meals. The under lying mechanism for gastrointestinal intolerance are proposed to be stimulation of intestinal secretion of serotonin, alteration in incretin and metabolism of glucose, and malabsorption of bile salts. Lactic acidosis is rare contraindication associated with metformin. Most reported cases of lactic acidosis occur in patients with contraindications, particularly impaired renal function. Metformin has a good safety profile, efficacy and comparatively reduced cost. Its ability to improve insulin sensitivity and the cardiovascular risk profile of type II diabetic patients has enhanced its clinical use as first-line therapy.
{"title":"A Review on Metformin: Clinical Significance and Side Effects","authors":"M. Avijit, Singh Ashini","doi":"10.31838/ijpr/2021.13.03.020","DOIUrl":"https://doi.org/10.31838/ijpr/2021.13.03.020","url":null,"abstract":"Metformin is a biguanide that has been used extensively worldwide for the treatment of type II diabetes mellitus. It improves glycaemic control by enhancing insulin sensitivity in liver and muscle. An advantage of metformin treatment is the tendency of weight reduction and the absence of significant hypoglycaemia; blood glucose levels are reduced only to normal as it does not stimulate insulin secretion. Metformin also has a beneficial effect on several cardiovascular risk factors including dyslipidemia, elevated plasminogen activator inhibitor 1 levels, other fibrinolytic abnormalities, hyperinsulinemia, and insulin resistance. Metformin enhances muscle and adipocyte insulin receptor number and/or affinity, increases insulin receptor tyrosine kinase activity, stimulates glucose transport and glycogen synthesis, and reduces both hepatic gluconeogenesis and glycogenolysis. The disadvantages are confined to the gastro-intestinal side effects and the potential risk of vitamin B 12 and folic acid deficiency during long-term use. These side effects can be minimized by slow titration and consumption with meals. The under lying mechanism for gastrointestinal intolerance are proposed to be stimulation of intestinal secretion of serotonin, alteration in incretin and metabolism of glucose, and malabsorption of bile salts. Lactic acidosis is rare contraindication associated with metformin. Most reported cases of lactic acidosis occur in patients with contraindications, particularly impaired renal function. Metformin has a good safety profile, efficacy and comparatively reduced cost. Its ability to improve insulin sensitivity and the cardiovascular risk profile of type II diabetic patients has enhanced its clinical use as first-line therapy.","PeriodicalId":14220,"journal":{"name":"International Journal of Pharmaceutical Research","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75198821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-02DOI: 10.31838/ijpr/2021.13.03.192
{"title":"Ayurvedic Management Of Knee Joint Pain Associated With Sthaulya- Single Case Study.","authors":"","doi":"10.31838/ijpr/2021.13.03.192","DOIUrl":"https://doi.org/10.31838/ijpr/2021.13.03.192","url":null,"abstract":"","PeriodicalId":14220,"journal":{"name":"International Journal of Pharmaceutical Research","volume":"142 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86240580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-02DOI: 10.31838/ijpr/2021.13.03.196
K. Choudhary, P. Garapati, S. Prasad, K. Murti, S. Singh, N. Kumar
The COVID-19 (SARS-Cov-2) pandemic has emerged in Wuhan city, China and spread globally. Despite Government lockdown process in India the number of infected people increases day by day. The only way to curb this pandemic is vaccination but still people are reluctant to receive COVID-19 vaccine. Hence online survey-based study was conducted to know Indians perception towards vaccination and reason behind their hesitancy. The online questionnaire in Google form has been circulated among people through Email and WhatsApp. 272 responses were included for analysis. The collected data were analysed by SPSS version 26 using t test and ANOVA by considering p value of less than 0.05 as significant. The study reveals that among participants 60% have good knowledge about COVID-19 and major source of information received from News (n=140), Social media (n=131) and Government website (n=101). The 58.8% among participants are willing to take vaccine and major reason behind hesitancy towards vaccine is side effect and safety concern. Focused intervention programmes and awareness campaign development will be essential by utilising social media and news channels. Govt. official needed to release newsletter through their website about safety and efficacy of vaccine to remove hesitancy among people.
{"title":"COVID-19 vaccine hesitancy assessment among the educated Indian population: An online survey","authors":"K. Choudhary, P. Garapati, S. Prasad, K. Murti, S. Singh, N. Kumar","doi":"10.31838/ijpr/2021.13.03.196","DOIUrl":"https://doi.org/10.31838/ijpr/2021.13.03.196","url":null,"abstract":"The COVID-19 (SARS-Cov-2) pandemic has emerged in Wuhan city, China and spread globally. Despite Government lockdown process in India the number of infected people increases day by day. The only way to curb this pandemic is vaccination but still people are reluctant to receive COVID-19 vaccine. Hence online survey-based study was conducted to know Indians perception towards vaccination and reason behind their hesitancy. The online questionnaire in Google form has been circulated among people through Email and WhatsApp. 272 responses were included for analysis. The collected data were analysed by SPSS version 26 using t test and ANOVA by considering p value of less than 0.05 as significant. The study reveals that among participants 60% have good knowledge about COVID-19 and major source of information received from News (n=140), Social media (n=131) and Government website (n=101). The 58.8% among participants are willing to take vaccine and major reason behind hesitancy towards vaccine is side effect and safety concern. Focused intervention programmes and awareness campaign development will be essential by utilising social media and news channels. Govt. official needed to release newsletter through their website about safety and efficacy of vaccine to remove hesitancy among people.","PeriodicalId":14220,"journal":{"name":"International Journal of Pharmaceutical Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79236929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-02DOI: 10.31838/ijpr/2021.13.03.198
{"title":"Anti-Helicobacter pylori activity of aqueous extracts from Achyrocline species and Pseudognaphalium gaudichaudianum","authors":"","doi":"10.31838/ijpr/2021.13.03.198","DOIUrl":"https://doi.org/10.31838/ijpr/2021.13.03.198","url":null,"abstract":"","PeriodicalId":14220,"journal":{"name":"International Journal of Pharmaceutical Research","volume":"66 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88470656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-02DOI: 10.31838/ijpr/2021.13.03.200
{"title":"Formulation and Evaluation of Lercanidipine Loaded Solid Lipid Nanoparticles By Design Of Experiment","authors":"","doi":"10.31838/ijpr/2021.13.03.200","DOIUrl":"https://doi.org/10.31838/ijpr/2021.13.03.200","url":null,"abstract":"","PeriodicalId":14220,"journal":{"name":"International Journal of Pharmaceutical Research","volume":"67 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91370215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-02DOI: 10.31838/ijpr/2021.13.03.199
{"title":"Preparationand In Vivo Evaluation Of A Self-Nanoemulsifying Drug Delivery System Loaded With Ceritinib","authors":"","doi":"10.31838/ijpr/2021.13.03.199","DOIUrl":"https://doi.org/10.31838/ijpr/2021.13.03.199","url":null,"abstract":"","PeriodicalId":14220,"journal":{"name":"International Journal of Pharmaceutical Research","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74810635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：