Pub Date : 2024-07-06DOI: 10.18203/2320-1770.ijrcog20241950
Parvathi T. Naik, Dilip K. Maurya, S. Jinkala
Nabothian cysts are benign mucous retention cysts of the cervix, most commonly seen in women of reproductive age. However, large Nabothian cysts may have a variable presentation and can even mimic malignancy, causing diagnostic dilemmas, especially during pregnancy. The case highlights the deep obstructive nature of the Nabothian cyst, which can mimic malignancy and must be differentiated from the invasive cervical lesion.
{"title":"Deep obstructive nabothian cyst in pregnancy mimicking adenocarcinoma on magnetic resonance imaging: an obstetricians dilemma","authors":"Parvathi T. Naik, Dilip K. Maurya, S. Jinkala","doi":"10.18203/2320-1770.ijrcog20241950","DOIUrl":"https://doi.org/10.18203/2320-1770.ijrcog20241950","url":null,"abstract":"Nabothian cysts are benign mucous retention cysts of the cervix, most commonly seen in women of reproductive age. However, large Nabothian cysts may have a variable presentation and can even mimic malignancy, causing diagnostic dilemmas, especially during pregnancy. The case highlights the deep obstructive nature of the Nabothian cyst, which can mimic malignancy and must be differentiated from the invasive cervical lesion.","PeriodicalId":14225,"journal":{"name":"International journal of reproduction, contraception, obstetrics and gynecology","volume":" 51","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141672809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-14DOI: 10.18203/2320-1770.ijrcog20241615
Quang Hien Tran
Background: Determining the rate of pregnant women infected with human immunodeficiency (HIV) is one of the important factors for planning HIV prevention policies. This study aims to determine the rate of HIV infection among pregnant women in An Giang province in 2010. Methods: This is an epidemiological investigation study with analysis. The subjects are all pregnant women who are from An Giang and reside in An Giang province. They came for prenatal check-ups and gave birth at all medical facilities in communes, districts, and the province of An Giang from 01 January 2010 to 31 December 2010. Results: The rate of pregnant women infected with HIV in An Giang province is 0.29%, which is at an average level compared to the whole country. The occupation of pregnant women is related to HIV infection; compared to the occupation of civil servants, the occupation of trading has an 18.7 times higher risk of HIV infection (RR=18.7, p<0.01); the occupation of laborer has a 13 times higher risk (p<0.05); the occupation of farmer has a 6.3 times higher risk (p<0.05); the occupation of Housewife has a 4 times higher risk (p<0.05). Conclusions: The rate of pregnant women infected with HIV in An Giang province in 2010 was 0.29%. The occupational factor of pregnant women shows a correlation with HIV infection.
{"title":"Determining the rate of mother-to-child human immunodeficiency virus transmission among pregnant women in An Giang province","authors":"Quang Hien Tran","doi":"10.18203/2320-1770.ijrcog20241615","DOIUrl":"https://doi.org/10.18203/2320-1770.ijrcog20241615","url":null,"abstract":"Background: Determining the rate of pregnant women infected with human immunodeficiency (HIV) is one of the important factors for planning HIV prevention policies. This study aims to determine the rate of HIV infection among pregnant women in An Giang province in 2010.\u0000Methods: This is an epidemiological investigation study with analysis. The subjects are all pregnant women who are from An Giang and reside in An Giang province. They came for prenatal check-ups and gave birth at all medical facilities in communes, districts, and the province of An Giang from 01 January 2010 to 31 December 2010.\u0000Results: The rate of pregnant women infected with HIV in An Giang province is 0.29%, which is at an average level compared to the whole country. The occupation of pregnant women is related to HIV infection; compared to the occupation of civil servants, the occupation of trading has an 18.7 times higher risk of HIV infection (RR=18.7, p<0.01); the occupation of laborer has a 13 times higher risk (p<0.05); the occupation of farmer has a 6.3 times higher risk (p<0.05); the occupation of Housewife has a 4 times higher risk (p<0.05).\u0000Conclusions: The rate of pregnant women infected with HIV in An Giang province in 2010 was 0.29%. The occupational factor of pregnant women shows a correlation with HIV infection.","PeriodicalId":14225,"journal":{"name":"International journal of reproduction, contraception, obstetrics and gynecology","volume":"61 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141338605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-06DOI: 10.18203/2320-1770.ijrcog20241606
Anand D. Bijwe, Smita A. Bijwe, Sameeullah B. A. Hassan, Minoti S. Pokale, D. Vidhale
Background: Traditional Indian medical education limits first-year MBBS students to classroom settings, delaying clinical exposure until the second year. Early clinical exposure (ECE) aims to integrate basic sciences with clinical practice, enhancing student understanding and interest through direct patient interaction. Aim was to assess first-year MBBS students' perceptions of ECE. Objectives were to introduce clinical settings to first-year students, and to explore students' experiences and attitudes towards ECE. Methods: The study was conducted at Dr. Panjabrao Deshmukh Memorial Medical College, Amravati, involving 100 first-year MBBS students. Ethical clearance and permissions were obtained. Students participated in bedside teaching in small groups over four weeks, focusing on clinical conditions and diagnostics. Observations in the radiology department included first-trimester ultrasounds with patient interaction. A qualitative approach using focus group discussions and a post-test questionnaire was employed. Results: Learning and knowledge: 81% found ECE helpful, interest in topic: 75% reported increased interest, motivation: 84% felt motivated to learn more, correlation with clinical features: 60% found it helpful, ward rounds: 89% valued participation, knowledge sharing: 87% appreciated discussion opportunities, and overall utility: 79% recognized ECE's utility. Feedback indicated significant enhancements in learning, interest, and motivation, despite some neutral or negative responses. Conclusions: ECE is a vital teaching tool that improves first-year MBBS students' understanding, motivation, and professional skills. Despite logistical challenges, its overall positive impact on medical education justifies its implementation.
{"title":"Qualitative study of attitude and efficacy of first year students to early clinical exposure in ultrasound and orthopedics","authors":"Anand D. Bijwe, Smita A. Bijwe, Sameeullah B. A. Hassan, Minoti S. Pokale, D. Vidhale","doi":"10.18203/2320-1770.ijrcog20241606","DOIUrl":"https://doi.org/10.18203/2320-1770.ijrcog20241606","url":null,"abstract":"Background: Traditional Indian medical education limits first-year MBBS students to classroom settings, delaying clinical exposure until the second year. Early clinical exposure (ECE) aims to integrate basic sciences with clinical practice, enhancing student understanding and interest through direct patient interaction. Aim was to assess first-year MBBS students' perceptions of ECE. Objectives were to introduce clinical settings to first-year students, and to explore students' experiences and attitudes towards ECE.\u0000Methods: The study was conducted at Dr. Panjabrao Deshmukh Memorial Medical College, Amravati, involving 100 first-year MBBS students. Ethical clearance and permissions were obtained. Students participated in bedside teaching in small groups over four weeks, focusing on clinical conditions and diagnostics. Observations in the radiology department included first-trimester ultrasounds with patient interaction. A qualitative approach using focus group discussions and a post-test questionnaire was employed.\u0000Results: Learning and knowledge: 81% found ECE helpful, interest in topic: 75% reported increased interest, motivation: 84% felt motivated to learn more, correlation with clinical features: 60% found it helpful, ward rounds: 89% valued participation, knowledge sharing: 87% appreciated discussion opportunities, and overall utility: 79% recognized ECE's utility. Feedback indicated significant enhancements in learning, interest, and motivation, despite some neutral or negative responses.\u0000Conclusions: ECE is a vital teaching tool that improves first-year MBBS students' understanding, motivation, and professional skills. Despite logistical challenges, its overall positive impact on medical education justifies its implementation.","PeriodicalId":14225,"journal":{"name":"International journal of reproduction, contraception, obstetrics and gynecology","volume":"3 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141380305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-06DOI: 10.18203/2320-1770.ijrcog20241607
Sara H. Elfaki
The biological factors and physiological functions fundamental to the female anatomy delineate the complexity of reproductive phenomenon in this population. When women experience menopausal transition, genital, sexual, and urinary signs and symptoms materialize often. These longstanding signs and symptoms, presently referred to as the genitourinary syndrome (GUS) of menopause, a relatively new term, impact their quality of life and sexual health with the emergence of vulvovaginal and urogenital atrophy, typical of irritation, soreness, dryness, dyspareunia, and itching. Despite its prevalence, GUS of menopause often goes unreported due to embarrassment, leading to underdiagnoses, diminished intervention, and under-treatment. Moreover, the rising life expectancy is also emerging as a contributing factor to the increasing prevalence of GUS of menopause, directly affecting women's health. While there are notable awareness, education, and healthcare frameworks in place aimed at addressing the unique needs of menopausal women, there is a need to explore further GUS’ prevalence, pathophysiology, risk factors, clinical features, diagnosis, and treatment to understand, diagnose, and effectively manage this condition.
{"title":"Genitourinary syndrome of menopause exploring the history, updates and treatment","authors":"Sara H. Elfaki","doi":"10.18203/2320-1770.ijrcog20241607","DOIUrl":"https://doi.org/10.18203/2320-1770.ijrcog20241607","url":null,"abstract":"The biological factors and physiological functions fundamental to the female anatomy delineate the complexity of reproductive phenomenon in this population. When women experience menopausal transition, genital, sexual, and urinary signs and symptoms materialize often. These longstanding signs and symptoms, presently referred to as the genitourinary syndrome (GUS) of menopause, a relatively new term, impact their quality of life and sexual health with the emergence of vulvovaginal and urogenital atrophy, typical of irritation, soreness, dryness, dyspareunia, and itching. Despite its prevalence, GUS of menopause often goes unreported due to embarrassment, leading to underdiagnoses, diminished intervention, and under-treatment. Moreover, the rising life expectancy is also emerging as a contributing factor to the increasing prevalence of GUS of menopause, directly affecting women's health. While there are notable awareness, education, and healthcare frameworks in place aimed at addressing the unique needs of menopausal women, there is a need to explore further GUS’ prevalence, pathophysiology, risk factors, clinical features, diagnosis, and treatment to understand, diagnose, and effectively manage this condition.","PeriodicalId":14225,"journal":{"name":"International journal of reproduction, contraception, obstetrics and gynecology","volume":"102 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141377995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-16DOI: 10.18203/2320-1770.ijrcog20241305
Suvidha Saurabh
Background: Contraception is the need of the hour in India. The family planning program in India offers a basket of choices. These choices are governed by the decisions of their partners, socio economic status of patients and even wishes of other family members. Methods: This observational study was carried out in obstetrics and gynaecology department of ESIC medical college and hospital for a period of 1 year from March 2023 to February 2024. All the patients who were in immediate post-partum period after normal vaginal delivery, caesarean section and medical termination of pregnancy were included in the study. Results: With the introduction of PPIUCD in national family programs more women are inclining towards long term spacing methods and not resorting to permanent sterilisation alone. Conclusions: It is undeniable that most women do not desire a pregnancy immediately after delivery but are not informed enough about the methods of contraception they can use.
{"title":"Contraceptive methods adopted by women in immediate post-partum period in a tertiary care centre in Northern India: an observational study","authors":"Suvidha Saurabh","doi":"10.18203/2320-1770.ijrcog20241305","DOIUrl":"https://doi.org/10.18203/2320-1770.ijrcog20241305","url":null,"abstract":"Background: Contraception is the need of the hour in India. The family planning program in India offers a basket of choices. These choices are governed by the decisions of their partners, socio economic status of patients and even wishes of other family members.\u0000Methods: This observational study was carried out in obstetrics and gynaecology department of ESIC medical college and hospital for a period of 1 year from March 2023 to February 2024. All the patients who were in immediate post-partum period after normal vaginal delivery, caesarean section and medical termination of pregnancy were included in the study.\u0000Results: With the introduction of PPIUCD in national family programs more women are inclining towards long term spacing methods and not resorting to permanent sterilisation alone.\u0000Conclusions: It is undeniable that most women do not desire a pregnancy immediately after delivery but are not informed enough about the methods of contraception they can use.","PeriodicalId":14225,"journal":{"name":"International journal of reproduction, contraception, obstetrics and gynecology","volume":"35 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140971066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-16DOI: 10.18203/2320-1770.ijrcog20241304
Wiwin Suhandri, Feldi Widianto
The health of both the mother and the fetus is at risk when symptomatic maternal arrhythmias occur during pregnancy. Sustained symptomatic arrhythmias should be managed, much like in the non-pregnant population. The specific arrhythmia that has been identified or is suspected must be treated. Electrical cardioversion is used to treat supraventricular arrhythmias when medication therapy and physical therapy, such as sinus carotid massage or valsalva movements, fail or in life-threatening conditions where the patient is hemodynamically unstable. A 27-year-old primipara came to Bengkalis hospital at 37 weeks of gestation due to complaints of palpitations. palpitations felt for 4 hours before admission to the hospital. The patient had experienced the same complaint and was examined by a cardiologist who said that the patient had a tendency to arrhythmia and was given bisoprolol. An ECG examination was carried out in the emergency room, the impression was supraventricular tachycardia with HR 185 bpm, an abdominal termination of pregnancy was carried out, and the cardiologist performed cardioversion in the operating room 3 times, and the mother's HR returned to sinus rhythm. The outcome was a baby girl born with a birth weight of 3200 grams, an Apgar score of 8/9. Mother was treated and went home on the 3rd postoperative day in good condition. Provided that a multidisciplinary approach, continuous fetal heart rate monitoring and the possibility to perform a caesarean section are applied, it can be concluded that cardioversion is a safe and effective treatment for maternal tachycardia in pregnancy.
{"title":"Cornual pregnancy with a history of recurrent ectopic pregnancy","authors":"Wiwin Suhandri, Feldi Widianto","doi":"10.18203/2320-1770.ijrcog20241304","DOIUrl":"https://doi.org/10.18203/2320-1770.ijrcog20241304","url":null,"abstract":"The health of both the mother and the fetus is at risk when symptomatic maternal arrhythmias occur during pregnancy. Sustained symptomatic arrhythmias should be managed, much like in the non-pregnant population. The specific arrhythmia that has been identified or is suspected must be treated. Electrical cardioversion is used to treat supraventricular arrhythmias when medication therapy and physical therapy, such as sinus carotid massage or valsalva movements, fail or in life-threatening conditions where the patient is hemodynamically unstable. A 27-year-old primipara came to Bengkalis hospital at 37 weeks of gestation due to complaints of palpitations. palpitations felt for 4 hours before admission to the hospital. The patient had experienced the same complaint and was examined by a cardiologist who said that the patient had a tendency to arrhythmia and was given bisoprolol. An ECG examination was carried out in the emergency room, the impression was supraventricular tachycardia with HR 185 bpm, an abdominal termination of pregnancy was carried out, and the cardiologist performed cardioversion in the operating room 3 times, and the mother's HR returned to sinus rhythm. The outcome was a baby girl born with a birth weight of 3200 grams, an Apgar score of 8/9. Mother was treated and went home on the 3rd postoperative day in good condition. Provided that a multidisciplinary approach, continuous fetal heart rate monitoring and the possibility to perform a caesarean section are applied, it can be concluded that cardioversion is a safe and effective treatment for maternal tachycardia in pregnancy.","PeriodicalId":14225,"journal":{"name":"International journal of reproduction, contraception, obstetrics and gynecology","volume":"46 24","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140970745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-14DOI: 10.18203/2320-1770.ijrcog20241300
Quang Hien Tran
Background: Pelvic organ prolapse is a common condition in Vietnam. At An Giang obstetrics and pediatrics hospital, vaginal mesh surgery for the treatment of female pelvic organ prolapse has recently been introduced, which is a new technique for the hospital and requires evaluation and research. This study aims to evaluate the treatment results of female pelvic organ prolapse by surgical placement of a synthetic vaginal mesh at An Giang obstetrics and pediatrics hospital in 2020-2021. Methods: Cross-sectional descriptive and prospective study. All women diagnosed with pelvic organ prolapse stage II or higher according to POP-Q criteria who underwent vaginal mesh placement surgery. Results: The study results of 47 cases of pelvic fractures showed that the average age of patients was 67 years old. The main anesthesia method was spinal anesthesia, accounting for 91.5%. The average surgery time was 97.1±21.2 minutes. The average blood loss during surgery was 70.2±55.5 ml. The average length of hospital stay was 6.1±1.9 days. Conclusions: The effectiveness of the surgical method of placing a synthetic vaginal graft for the treatment of female pelvic organ prolapse achieves a success rate of 95.7%. 98% of patients express satisfaction with this surgical method and are enthusiastic about recommending this surgical method to other women.
背景：盆腔器官脱垂是越南的一种常见病。安江产科和儿科医院最近引进了阴道网片手术治疗女性盆腔器官脱垂，这对医院来说是一项新技术，需要进行评估和研究。本研究旨在评估 2020-2021 年安江产科和儿科医院通过手术置入合成阴道网片治疗女性盆腔器官脱垂的效果：方法：横断面描述性前瞻性研究。所有根据 POP-Q 标准诊断为盆腔器官脱垂 II 期或 II 期以上并接受阴道网片置入手术的女性：47例骨盆骨折患者的研究结果显示，患者的平均年龄为67岁。主要麻醉方法为脊髓麻醉，占 91.5%。平均手术时间为（97.1±21.2）分钟。手术中平均失血量为 70.2±55.5 毫升。平均住院时间为 6.1±1.9 天：结论：人工阴道移植手术治疗女性盆腔器官脱垂的成功率高达 95.7%。98%的患者对这种手术方法表示满意，并热衷于向其他女性推荐这种手术方法。
{"title":"Treatment results of female pelvic organ prolapse by surgical placement of synthetic vaginal mesh: a prospective study at An Giang Obstetrics and Pediatrics Hospital","authors":"Quang Hien Tran","doi":"10.18203/2320-1770.ijrcog20241300","DOIUrl":"https://doi.org/10.18203/2320-1770.ijrcog20241300","url":null,"abstract":"Background: Pelvic organ prolapse is a common condition in Vietnam. At An Giang obstetrics and pediatrics hospital, vaginal mesh surgery for the treatment of female pelvic organ prolapse has recently been introduced, which is a new technique for the hospital and requires evaluation and research. This study aims to evaluate the treatment results of female pelvic organ prolapse by surgical placement of a synthetic vaginal mesh at An Giang obstetrics and pediatrics hospital in 2020-2021.\u0000Methods: Cross-sectional descriptive and prospective study. All women diagnosed with pelvic organ prolapse stage II or higher according to POP-Q criteria who underwent vaginal mesh placement surgery.\u0000Results: The study results of 47 cases of pelvic fractures showed that the average age of patients was 67 years old. The main anesthesia method was spinal anesthesia, accounting for 91.5%. The average surgery time was 97.1±21.2 minutes. The average blood loss during surgery was 70.2±55.5 ml. The average length of hospital stay was 6.1±1.9 days.\u0000Conclusions: The effectiveness of the surgical method of placing a synthetic vaginal graft for the treatment of female pelvic organ prolapse achieves a success rate of 95.7%. 98% of patients express satisfaction with this surgical method and are enthusiastic about recommending this surgical method to other women.","PeriodicalId":14225,"journal":{"name":"International journal of reproduction, contraception, obstetrics and gynecology","volume":"33 29","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140980236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: The aim of the study was to compare the efficacy and safety of novel once-daily extended-release (ER) dydrogesterone 20 mg versus conventional twice-daily dydrogesterone 10 mg in Indian patients with endometriosis. Methods: A phase III prospective, randomized, double-blind, single-dummy, two-arm, active-controlled, parallel, multicenter study was performed in six gynecology centers across India. The patients of 18 to 45 years of age with a confirmed diagnosis of endometriosis on ultrasonography (USG) and having endometriosis-associated pelvic pain score (EAPP) of at least 30 mm on a 100 mm visual analog scale (VAS) were randomly assigned to a 1:1 ratio to either once-daily dydrogesterone ER 20 mg or twice-daily dydrogesterone 10 mg arms for a treatment period of 90 days. The primary outcome was a change from baseline in EAPP score at the end of the treatment. Results: A total of 228 patients with a mean age of 31.8±6.9 years were enrolled in the study. At day 90, both the treatment arms showed a significant reduction (p<0.05) in EAPP score from baseline (i.e. -34.2±15.3 mm and -33.1±14.8 mm in once daily dydrogesterone ER and twice daily dydrogesterone 10 mg, respectively), with no significant difference between the two arms (p=0.53). With both formulations, patients experienced a significant reduction in the size of endometrioma, serum vascular endothelial growth factors (VEGF) levels, use of rescue analgesics, and significant improvement in the health-related quality-of-life parameters. A favorable safety profile of dydrogesterone was confirmed, and no significant safety concerns were reported during the study. Conclusions: Once daily dydrogesterone ER 20 mg and twice daily dydrogesterone 10 mg demonstrated a significant and similar reduction in EAPP and all other secondary parameters along with marked improvements in parameters related to quality of life.
研究背景该研究旨在比较新型每日一次缓释（ER）地屈孕酮 20 毫克与传统每日两次地屈孕酮 10 毫克在印度子宫内膜异位症患者中的疗效和安全性：在印度的六个妇科中心开展了一项 III 期前瞻性、随机、双盲、单剂量、双臂、主动对照、平行、多中心研究。经超声波检查（USG）确诊为子宫内膜异位症且子宫内膜异位症相关盆腔疼痛评分（EAPP）在100毫米视觉模拟量表（VAS）上至少达到30毫米的18至45岁患者，按1:1的比例随机分配到每天一次的地屈孕酮ER 20毫克或每天两次的地屈孕酮10毫克治疗组，治疗期为90天。主要结果是治疗结束时EAPP评分与基线相比的变化：共有 228 名患者参加了研究，平均年龄（31.8±6.9）岁。在第 90 天，两种治疗方案的 EAPP 评分均比基线显著降低（p<0.05）（即每日一次地屈孕酮 ER 为 -34.2±15.3 mm，每日两次地屈孕酮 10 mg 为 -33.1±14.8 mm），两种治疗方案之间无显著差异（p=0.53）。使用这两种制剂后，患者的子宫内膜异位瘤大小、血清血管内皮生长因子（VEGF）水平、止痛药使用量均显著减少，与健康相关的生活质量参数也明显改善。研究证实，地屈孕酮具有良好的安全性，在研究过程中未出现重大安全问题：结论：每日一次的地屈孕酮 ER 20 毫克和每日两次的地屈孕酮 10 毫克可显著降低 EAPP 和所有其他次要参数，并明显改善与生活质量相关的参数。
{"title":"A multicentre phase III study comparing efficacy and safety of novel extended-release versus conventional formulation of dydrogesterone in Indian patients with endometriosis","authors":"T. Sasikala, Shikha Kushwaha, Mukta Agarwal, Vandana Jain, Deepti Bawa, Suchitra Narayan, Pavankumar Daultani, Ashok Jaiswal, Monika Chinda, Anit Singh","doi":"10.18203/2320-1770.ijrcog20241298","DOIUrl":"https://doi.org/10.18203/2320-1770.ijrcog20241298","url":null,"abstract":"Background: The aim of the study was to compare the efficacy and safety of novel once-daily extended-release (ER) dydrogesterone 20 mg versus conventional twice-daily dydrogesterone 10 mg in Indian patients with endometriosis.\u0000Methods: A phase III prospective, randomized, double-blind, single-dummy, two-arm, active-controlled, parallel, multicenter study was performed in six gynecology centers across India. The patients of 18 to 45 years of age with a confirmed diagnosis of endometriosis on ultrasonography (USG) and having endometriosis-associated pelvic pain score (EAPP) of at least 30 mm on a 100 mm visual analog scale (VAS) were randomly assigned to a 1:1 ratio to either once-daily dydrogesterone ER 20 mg or twice-daily dydrogesterone 10 mg arms for a treatment period of 90 days. The primary outcome was a change from baseline in EAPP score at the end of the treatment.\u0000Results: A total of 228 patients with a mean age of 31.8±6.9 years were enrolled in the study. At day 90, both the treatment arms showed a significant reduction (p<0.05) in EAPP score from baseline (i.e. -34.2±15.3 mm and -33.1±14.8 mm in once daily dydrogesterone ER and twice daily dydrogesterone 10 mg, respectively), with no significant difference between the two arms (p=0.53). With both formulations, patients experienced a significant reduction in the size of endometrioma, serum vascular endothelial growth factors (VEGF) levels, use of rescue analgesics, and significant improvement in the health-related quality-of-life parameters. A favorable safety profile of dydrogesterone was confirmed, and no significant safety concerns were reported during the study.\u0000Conclusions: Once daily dydrogesterone ER 20 mg and twice daily dydrogesterone 10 mg demonstrated a significant and similar reduction in EAPP and all other secondary parameters along with marked improvements in parameters related to quality of life.","PeriodicalId":14225,"journal":{"name":"International journal of reproduction, contraception, obstetrics and gynecology","volume":"63 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140983380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Although knowledge, attitude and need of pelvic floor muscle training are well established but there is lack of practice of PFMT even in fitness oriented educated women. Objective was to evaluate the knowledge, Attitude, Practice (KAP) of PFMT in fitness-oriented women. Methods: A Cross-sectional study was performed on 100 women of 18-45 years who are not pregnant and fitness oriented by providing a self-administrated KAP questionnaire then all answers were analysed. Results: A total of 100 women were included in the study and baseline characteristics were determined. Out of 100 participants 97% had the knowledge about the pelvic floor muscle while 95% knew about its exercise with 100% of them believed it to be a good practice. The results showed significant association with the knowledge of PFMT to the educational status. Despite In spite of high quality of knowledge, attitude and awareness regarding pelvic floor muscle and its training, unfortunately only 8% of educated females practiced pelvic floor muscle exercises in their daily routine. Conclusions: So, we conclude that pelvic floor muscle training should be inculcated in our society at the very root levels or even in school education like other exercises or meditation. Essential motivation, education and awareness should be spread through various possible means.
{"title":"A prospective knowledge, attitude and practice-based study of pelvic floor muscle training in fitness-oriented women","authors":"Fayaz Khan H., Shweta Gupta, Mukul Chandra, Fariza Siddiqui, Bhuvneshwari Upadhyay","doi":"10.18203/2320-1770.ijrcog20241295","DOIUrl":"https://doi.org/10.18203/2320-1770.ijrcog20241295","url":null,"abstract":"Background: Although knowledge, attitude and need of pelvic floor muscle training are well established but there is lack of practice of PFMT even in fitness oriented educated women. Objective was to evaluate the knowledge, Attitude, Practice (KAP) of PFMT in fitness-oriented women.\u0000Methods: A Cross-sectional study was performed on 100 women of 18-45 years who are not pregnant and fitness oriented by providing a self-administrated KAP questionnaire then all answers were analysed.\u0000Results: A total of 100 women were included in the study and baseline characteristics were determined. Out of 100 participants 97% had the knowledge about the pelvic floor muscle while 95% knew about its exercise with 100% of them believed it to be a good practice. The results showed significant association with the knowledge of PFMT to the educational status. Despite In spite of high quality of knowledge, attitude and awareness regarding pelvic floor muscle and its training, unfortunately only 8% of educated females practiced pelvic floor muscle exercises in their daily routine.\u0000Conclusions: So, we conclude that pelvic floor muscle training should be inculcated in our society at the very root levels or even in school education like other exercises or meditation. Essential motivation, education and awareness should be spread through various possible means.","PeriodicalId":14225,"journal":{"name":"International journal of reproduction, contraception, obstetrics and gynecology","volume":" 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140994819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-04DOI: 10.18203/2320-1770.ijrcog20241281
T. R. Laila, Khairun Nahar, Sheikh Salahuddin Ahmed, B. Chakma, Walida Afrin, Samira Moyeen, Hasina Khatun, Shakeela Ishrat
Background: In abnormal uterine bleeding due to ovulation dysfunction, unopposed estrogen causes persistent proliferative or hyperplastic endometrium and periods of amenorrhea followed by excessive bleeding. This is managed medically by cyclical use of some hormonal agents. The aim of the study was to compare the effectiveness and acceptability of cyclical progestin alone and low dose estrogen progestin pill as medical management of AUB-O in premenopausal women. Methods: The study composed of 57 premenopausal women with anovular type of bleeding. The study participants were randomly allocated to take either norethisterone 10 mg daily from 16th to 25th day of menstrual cycle or low dose estrogen progesterone pill, one pill daily from 1st day of menstrual cycle up to 24th day. These patients were followed up after three and six months to assess subjectively the persistence of abnormal uterine bleeding, patient’s satisfaction, need for hysterectomy and any side effects. Results: The symptomatic improvement was more apparent with estrogen progestin pill than cyclical norethisterone. More patients chose hysterectomy in the norethisterone group because they were not satisfied with medical management. Conclusions: Symptomatic improvement is more with low dose estrogen progestin pill than cyclical norethisterone in women with AUB-O. More women decline hysterectomy as they accept estrogen progestin pill.
{"title":"Low dose estrogen progestin pill is better than cyclical progestin as medical management of abnormal uterine bleeding due to ovulatory dysfunction in premenopausal women","authors":"T. R. Laila, Khairun Nahar, Sheikh Salahuddin Ahmed, B. Chakma, Walida Afrin, Samira Moyeen, Hasina Khatun, Shakeela Ishrat","doi":"10.18203/2320-1770.ijrcog20241281","DOIUrl":"https://doi.org/10.18203/2320-1770.ijrcog20241281","url":null,"abstract":"Background: In abnormal uterine bleeding due to ovulation dysfunction, unopposed estrogen causes persistent proliferative or hyperplastic endometrium and periods of amenorrhea followed by excessive bleeding. This is managed medically by cyclical use of some hormonal agents. The aim of the study was to compare the effectiveness and acceptability of cyclical progestin alone and low dose estrogen progestin pill as medical management of AUB-O in premenopausal women.\u0000Methods: The study composed of 57 premenopausal women with anovular type of bleeding. The study participants were randomly allocated to take either norethisterone 10 mg daily from 16th to 25th day of menstrual cycle or low dose estrogen progesterone pill, one pill daily from 1st day of menstrual cycle up to 24th day. These patients were followed up after three and six months to assess subjectively the persistence of abnormal uterine bleeding, patient’s satisfaction, need for hysterectomy and any side effects.\u0000Results: The symptomatic improvement was more apparent with estrogen progestin pill than cyclical norethisterone. More patients chose hysterectomy in the norethisterone group because they were not satisfied with medical management.\u0000Conclusions: Symptomatic improvement is more with low dose estrogen progestin pill than cyclical norethisterone in women with AUB-O. More women decline hysterectomy as they accept estrogen progestin pill.","PeriodicalId":14225,"journal":{"name":"International journal of reproduction, contraception, obstetrics and gynecology","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141013139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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