Pub Date : 2023-10-01DOI: 10.47583/ijpsrr.2023.v82i02.019
Jalajakshi. M. N, V. Chandrakala, S. Srinivasan
Objective: The objective of the present study was to compare the release effect of Etodolac from different polymeric (hydrophilic and lipophilic) patches prepared by varying concentrations. The best polymeric combination was selected based on the release of the drug from the patches. Methods: Polymers such as HPMC, MC, EC, PVA, Eudragit L-100, and Glycerin was used as a plasticizer. Permeation Enhancers used is Dimethyl Sulfoxide. Transdermal patches were prepared by using the solvent casting technique. FTIR was studied to estimate the incompatibility. Patches were evaluated for physicochemical Characteristics like thickness, weight variation, folding endurance, moisture loss, moisture absorption, water vapor transition, drug content, and In-vitro diffusion studies. Results: The results obtained showed no physical-chemical incompatibility between the drug and the polymers. MC: EC was found to be a suitable polymer compared to other prepared polymeric combinations in the preparation of transdermal patches. From the evaluation of patches F6 containing (1:3) % of MC: EC was considered the best formulation for the transdermal delivery of Etodolac. Conclusion: Transdermal patches were successfully prepared for Etodolac and their evaluation studies of each dosage form revealed that topically applied Etodolac patches possess immense potential to control the release rate of medicament to improve the bioavailability as well as patient compliance.
{"title":"Preparation and Evaluation of Transdermal Patches of an Anti-inflammatory Drug","authors":"Jalajakshi. M. N, V. Chandrakala, S. Srinivasan","doi":"10.47583/ijpsrr.2023.v82i02.019","DOIUrl":"https://doi.org/10.47583/ijpsrr.2023.v82i02.019","url":null,"abstract":"Objective: The objective of the present study was to compare the release effect of Etodolac from different polymeric (hydrophilic and lipophilic) patches prepared by varying concentrations. The best polymeric combination was selected based on the release of the drug from the patches. Methods: Polymers such as HPMC, MC, EC, PVA, Eudragit L-100, and Glycerin was used as a plasticizer. Permeation Enhancers used is Dimethyl Sulfoxide. Transdermal patches were prepared by using the solvent casting technique. FTIR was studied to estimate the incompatibility. Patches were evaluated for physicochemical Characteristics like thickness, weight variation, folding endurance, moisture loss, moisture absorption, water vapor transition, drug content, and In-vitro diffusion studies. Results: The results obtained showed no physical-chemical incompatibility between the drug and the polymers. MC: EC was found to be a suitable polymer compared to other prepared polymeric combinations in the preparation of transdermal patches. From the evaluation of patches F6 containing (1:3) % of MC: EC was considered the best formulation for the transdermal delivery of Etodolac. Conclusion: Transdermal patches were successfully prepared for Etodolac and their evaluation studies of each dosage form revealed that topically applied Etodolac patches possess immense potential to control the release rate of medicament to improve the bioavailability as well as patient compliance.","PeriodicalId":14255,"journal":{"name":"International Journal of Pharmaceutical Sciences Review and Research","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136204774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-01DOI: 10.47583/ijpsrr.2023.v82i02.021
Debarati Roy, Mousumi Dutta, Sourapriya Mukherjee, Goutam Paul
{"title":"Bisphenol S (BPS) Alters Xanthine Oxidoreductase Activity to Elevate Oxidative Stress Mediated Protein Carbonylation in Small Intestine of Rat ex vivo","authors":"Debarati Roy, Mousumi Dutta, Sourapriya Mukherjee, Goutam Paul","doi":"10.47583/ijpsrr.2023.v82i02.021","DOIUrl":"https://doi.org/10.47583/ijpsrr.2023.v82i02.021","url":null,"abstract":"","PeriodicalId":14255,"journal":{"name":"International Journal of Pharmaceutical Sciences Review and Research","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136204859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-01DOI: 10.47583/ijpsrr.2023.v82i02.011
Dr. Rakesh Kumar Sinha, Dr. Niraj Kumar Mishra, Dr. Deepak Kumar
{"title":"Comparison of Pre and Post Anaesthetic Urinary Protein in Patients of Chronic Kidney Disease undergoing Abdominal Surgery under General Anaesthesia","authors":"Dr. Rakesh Kumar Sinha, Dr. Niraj Kumar Mishra, Dr. Deepak Kumar","doi":"10.47583/ijpsrr.2023.v82i02.011","DOIUrl":"https://doi.org/10.47583/ijpsrr.2023.v82i02.011","url":null,"abstract":"","PeriodicalId":14255,"journal":{"name":"International Journal of Pharmaceutical Sciences Review and Research","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136204766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acetaminophen or Paracetamol is well known for its antipyretic and analgesic properties. As it has both analgesic and antipyretic properties, it is mostly preferred over other analgesics and antipyretics. It is a commonly used analgesic and antipyretic agent in children. It is being used in children in various dosage forms like syrup dosage forms or tablet dosage forms according to their age. And when any drug is being administered to children, it is the most concerning matter. If Acetaminophen or Paracetamol is administered in proper dose, it does not cause any unintended effect in children. But it can be heavily dangerous if it is being used too much. When the dose is a little high or somehow the child takes too much of the medication, it can cause drug overdose, basically it can be said that Acetaminophen or Paracetamol overdose which in turn can cause drug induced toxicity. This toxicity in children may lead to hospitalization and even death. Over the years, after cosmetic induced health problems, Paracetamol toxicity remains the most common problems which can be seen everywhere around the whole world. Though the symptoms are not obvious, some of the most common symptoms of Acetaminophen or Paracetamol toxicity are: i) Nausea and vomiting, ii) Drowsiness, iii) Loss of consciousness, etc. The treatment of the Paracetamol or Acetaminophen toxicity varies and it’s mainly depending on the seriousness of the condition. N-acetylcysteine is used for the toxicity caused by Acetaminophen or Paracetamol overdose and can be administered orally or intravenously.
{"title":"Exploring the Efficacy of N-Acetylcysteine as a Novel Treatment for Acetaminophen or Paracetamol Toxicity in Pediatrics: A Comprehensive Review","authors":"Disha Das, Mithun Bhowmick, Sanjit Mandal, Somenath Bhattacharya","doi":"10.47583/ijpsrr.2023.v82i02.013","DOIUrl":"https://doi.org/10.47583/ijpsrr.2023.v82i02.013","url":null,"abstract":"Acetaminophen or Paracetamol is well known for its antipyretic and analgesic properties. As it has both analgesic and antipyretic properties, it is mostly preferred over other analgesics and antipyretics. It is a commonly used analgesic and antipyretic agent in children. It is being used in children in various dosage forms like syrup dosage forms or tablet dosage forms according to their age. And when any drug is being administered to children, it is the most concerning matter. If Acetaminophen or Paracetamol is administered in proper dose, it does not cause any unintended effect in children. But it can be heavily dangerous if it is being used too much. When the dose is a little high or somehow the child takes too much of the medication, it can cause drug overdose, basically it can be said that Acetaminophen or Paracetamol overdose which in turn can cause drug induced toxicity. This toxicity in children may lead to hospitalization and even death. Over the years, after cosmetic induced health problems, Paracetamol toxicity remains the most common problems which can be seen everywhere around the whole world. Though the symptoms are not obvious, some of the most common symptoms of Acetaminophen or Paracetamol toxicity are: i) Nausea and vomiting, ii) Drowsiness, iii) Loss of consciousness, etc. The treatment of the Paracetamol or Acetaminophen toxicity varies and it’s mainly depending on the seriousness of the condition. N-acetylcysteine is used for the toxicity caused by Acetaminophen or Paracetamol overdose and can be administered orally or intravenously.","PeriodicalId":14255,"journal":{"name":"International Journal of Pharmaceutical Sciences Review and Research","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136204864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The interest of scientists and medical professionals in herbal medicinal products containing phytochemicals derived from plants is growing daily due to the shift of consumers’ preferences from convenience to environmental sustainability. One plant utilized in many medicines is Morinda citrifolia L., a tree commonly used in folk medicine, health supplements and immune-boosting products. In this study, Bioactive compounds from M . citrifolia were extracted using conventional methods and modern methods (Ultrasound-Assisted, Microwave Assisted, Water bath Assisted, Shaker Assisted, Soxhlet Assisted and Magnetic Stirrer Assisted Extraction). This study screens a variety of extraction methods used to extract active compounds: total phenolic content and antioxidant properties through DPPH, ABTS and FRAP from different parts of M. citrifolia . The results indicate that the total phenolic content and FRAP activity were highest in all parts of the plant in Soxhlet Assisted extraction. In contrast, Microwave Assisted extraction showed high DPPH and ABTS activity. This study offered valuable details on the effective phytochemical extraction processes from various parts of Morinda citrifolia L.
{"title":"Screening of Different Extraction Methods for Quantitative and Qualitative Analysis of Antioxidants and Assessment of Free Radical Scavenging Activity in Morinda citrifolia L.","authors":"Anjali Anjali, Pushpendra Pushpendra, Vimala Yerramilli, Ishwar Singh, Rup Narayan","doi":"10.47583/ijpsrr.2023.v82i02.001","DOIUrl":"https://doi.org/10.47583/ijpsrr.2023.v82i02.001","url":null,"abstract":"The interest of scientists and medical professionals in herbal medicinal products containing phytochemicals derived from plants is growing daily due to the shift of consumers’ preferences from convenience to environmental sustainability. One plant utilized in many medicines is Morinda citrifolia L., a tree commonly used in folk medicine, health supplements and immune-boosting products. In this study, Bioactive compounds from M . citrifolia were extracted using conventional methods and modern methods (Ultrasound-Assisted, Microwave Assisted, Water bath Assisted, Shaker Assisted, Soxhlet Assisted and Magnetic Stirrer Assisted Extraction). This study screens a variety of extraction methods used to extract active compounds: total phenolic content and antioxidant properties through DPPH, ABTS and FRAP from different parts of M. citrifolia . The results indicate that the total phenolic content and FRAP activity were highest in all parts of the plant in Soxhlet Assisted extraction. In contrast, Microwave Assisted extraction showed high DPPH and ABTS activity. This study offered valuable details on the effective phytochemical extraction processes from various parts of Morinda citrifolia L.","PeriodicalId":14255,"journal":{"name":"International Journal of Pharmaceutical Sciences Review and Research","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136204861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: The instant pattern recognition seen in neoplastic, and few infectious disorders is not seen in inflammatory dermatoses. An overall assessment of the clinical features and microscopic features aids in the diagnosis of inflammatory lesions which have several overlapping features in common. Inflammatory dermatoses include psoriasiform diseases, lichenoid diseases, vasculopathic diseases, spongiotic diseases and vesiculobullous diseases. Aim: The current study is aimed to evaluate the pathological findings in inflammatory skin lesions and to compare with the pathological with clinical findings. Material and methods: This is a study conducted at GITAM institute of medical sciences and research for a period of 18 months i.e., from January 2022 to June 2023. All the skin biopsies received at the department of pathology, GIMSR. Using 10% formalin they were subjected to fixation and processed in automatic tissue processor and after taking 3-4 microns sections, staining was done with eosin and hematoxylin and a final histopathological diagnosis was made. Results: The patterns of various tissue reactions were observed in our study were Lichenoid reaction pattern (23%), Psoriasiform reaction pattern (39%), Spongiotic reaction pattern (22.7%), Vesiculobullous reaction pattern (4.5%), Vasculopathic reaction pattern (7.9%).In our study the most common inflammatory dermatoses observed was psoriasis 26% (23 cases), variants of lichen planus 12.5% (11 cases), pityriasis Rosea 6.8% (6 cases) followed by 5.6% (5 cases) spongiotic dermatitis and leucocytoclastic vasculitis each. In 72 cases (82%) there was agreement between the clinical and histological diagnoses, whereas in 16 cases (18%) there was a discrepancy. Conclusion: To narrow the differential diagnosis and arrive at the most accurate diagnosis, a systematic approach during histopathological assessment and sorting inflammatory dermatoses based on the reaction pattern are crucial.
{"title":"A Clinicopathological Study of Inflammatory Dermatoses","authors":"Prasanthi Cherukuri, Vasundara Gardas, Sanjana Nutakki","doi":"10.47583/ijpsrr.2023.v82i02.017","DOIUrl":"https://doi.org/10.47583/ijpsrr.2023.v82i02.017","url":null,"abstract":"Introduction: The instant pattern recognition seen in neoplastic, and few infectious disorders is not seen in inflammatory dermatoses. An overall assessment of the clinical features and microscopic features aids in the diagnosis of inflammatory lesions which have several overlapping features in common. Inflammatory dermatoses include psoriasiform diseases, lichenoid diseases, vasculopathic diseases, spongiotic diseases and vesiculobullous diseases. Aim: The current study is aimed to evaluate the pathological findings in inflammatory skin lesions and to compare with the pathological with clinical findings. Material and methods: This is a study conducted at GITAM institute of medical sciences and research for a period of 18 months i.e., from January 2022 to June 2023. All the skin biopsies received at the department of pathology, GIMSR. Using 10% formalin they were subjected to fixation and processed in automatic tissue processor and after taking 3-4 microns sections, staining was done with eosin and hematoxylin and a final histopathological diagnosis was made. Results: The patterns of various tissue reactions were observed in our study were Lichenoid reaction pattern (23%), Psoriasiform reaction pattern (39%), Spongiotic reaction pattern (22.7%), Vesiculobullous reaction pattern (4.5%), Vasculopathic reaction pattern (7.9%).In our study the most common inflammatory dermatoses observed was psoriasis 26% (23 cases), variants of lichen planus 12.5% (11 cases), pityriasis Rosea 6.8% (6 cases) followed by 5.6% (5 cases) spongiotic dermatitis and leucocytoclastic vasculitis each. In 72 cases (82%) there was agreement between the clinical and histological diagnoses, whereas in 16 cases (18%) there was a discrepancy. Conclusion: To narrow the differential diagnosis and arrive at the most accurate diagnosis, a systematic approach during histopathological assessment and sorting inflammatory dermatoses based on the reaction pattern are crucial.","PeriodicalId":14255,"journal":{"name":"International Journal of Pharmaceutical Sciences Review and Research","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136204768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-01DOI: 10.47583/ijpsrr.2023.v82i02.025
A Meena, M. Sasikumar, G. Selvamurugan, P. Senthamizhan, K. Senthamizhselvan, S.Shafeena Begum
{"title":"Review About Pharmacovigilance of Vaccine","authors":"A Meena, M. Sasikumar, G. Selvamurugan, P. Senthamizhan, K. Senthamizhselvan, S.Shafeena Begum","doi":"10.47583/ijpsrr.2023.v82i02.025","DOIUrl":"https://doi.org/10.47583/ijpsrr.2023.v82i02.025","url":null,"abstract":"","PeriodicalId":14255,"journal":{"name":"International Journal of Pharmaceutical Sciences Review and Research","volume":"67 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136204776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-01DOI: 10.47583/ijpsrr.2023.v82i02.020
Dr. Gita Bipin Chandra, Dr. Bindey Kumar, Dr. Swarnika Singh
{"title":"Efficacy and Safety of Apixaban Versus Warfarin in Patients with Atrial Fibrillation and Chronic Kidney Disease: A Randomised Controlled Trial","authors":"Dr. Gita Bipin Chandra, Dr. Bindey Kumar, Dr. Swarnika Singh","doi":"10.47583/ijpsrr.2023.v82i02.020","DOIUrl":"https://doi.org/10.47583/ijpsrr.2023.v82i02.020","url":null,"abstract":"","PeriodicalId":14255,"journal":{"name":"International Journal of Pharmaceutical Sciences Review and Research","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136204869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.47583/ijpsrr.2023.v82i01.011
Ayoob Mansoor Akkaparambil, Shehin V Shanavas, Rismi Shirin
Pemphigus vulgaris (PV) is a rare autoimmune disease that is characterized by painful blistering and erosion of the skin and mucous membrane. In the case in hand, a female patient of 44 years was presented with complaints of painful vesicles all over the body with erosions, with no history of fever, headache, or cough. The patient had previously been treated for the lesions over the body, considering them to be chicken pox. The patient was admitted to our hospital without any relief. A skin biopsy was done, a specimen was sent for direct immunofluorescence, and the reports were consistent with pemphigus vulgaris. Blood investigation reports revealed the presence of neutrophilic leucocytosis, elevated CRP, hyponatremia, and hypoalbuminemia. The treatment started with IV Dexamethasone (8mg q 8 hours) along with analgesics, IV fluids, and saline soakings. Secondary infections were managed with antibiotics, antibacterial creams, and other supportive medicines. The patient was provided with sodium supplementation and was advised to eat a protein-rich diet. During the hospital stay, the patient developed foul-smelling discharge from vesicles, and antibiotic treatment was escalated, suspecting pseudomonal infections. Antibiotic ear drops were added to the regimen for painful lesions in the ear and mouth. Artificial tears were added for painful eye lesions. The patient was discharged symptomatically better with sterile blood and pus cultures, healthy skin, and a tapered steroid dose. It is important to consider the nutritional requirements of the patient. Due to the painful nature of oral lesions, PV can result in an impaired nutritional status.
{"title":"A Case on Pemphigus Vulgaris with Superadded Infection, Hypoalbuminemia and Hyponatremia","authors":"Ayoob Mansoor Akkaparambil, Shehin V Shanavas, Rismi Shirin","doi":"10.47583/ijpsrr.2023.v82i01.011","DOIUrl":"https://doi.org/10.47583/ijpsrr.2023.v82i01.011","url":null,"abstract":"Pemphigus vulgaris (PV) is a rare autoimmune disease that is characterized by painful blistering and erosion of the skin and mucous membrane. In the case in hand, a female patient of 44 years was presented with complaints of painful vesicles all over the body with erosions, with no history of fever, headache, or cough. The patient had previously been treated for the lesions over the body, considering them to be chicken pox. The patient was admitted to our hospital without any relief. A skin biopsy was done, a specimen was sent for direct immunofluorescence, and the reports were consistent with pemphigus vulgaris. Blood investigation reports revealed the presence of neutrophilic leucocytosis, elevated CRP, hyponatremia, and hypoalbuminemia. The treatment started with IV Dexamethasone (8mg q 8 hours) along with analgesics, IV fluids, and saline soakings. Secondary infections were managed with antibiotics, antibacterial creams, and other supportive medicines. The patient was provided with sodium supplementation and was advised to eat a protein-rich diet. During the hospital stay, the patient developed foul-smelling discharge from vesicles, and antibiotic treatment was escalated, suspecting pseudomonal infections. Antibiotic ear drops were added to the regimen for painful lesions in the ear and mouth. Artificial tears were added for painful eye lesions. The patient was discharged symptomatically better with sterile blood and pus cultures, healthy skin, and a tapered steroid dose. It is important to consider the nutritional requirements of the patient. Due to the painful nature of oral lesions, PV can result in an impaired nutritional status.","PeriodicalId":14255,"journal":{"name":"International Journal of Pharmaceutical Sciences Review and Research","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135637729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：