Pub Date : 2023-09-01DOI: 10.47583/ijpsrr.2023.v82i01.004
Ram Pal, Mohammad Mujahid, Shamim Ahmad
{"title":"Formulation Development and in-vitro Evaluation of Linagliptin Transdermal Patch Using Permeability Enhancer","authors":"Ram Pal, Mohammad Mujahid, Shamim Ahmad","doi":"10.47583/ijpsrr.2023.v82i01.004","DOIUrl":"https://doi.org/10.47583/ijpsrr.2023.v82i01.004","url":null,"abstract":"","PeriodicalId":14255,"journal":{"name":"International Journal of Pharmaceutical Sciences Review and Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135637722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.47583/ijpsrr.2023.v82i01.007
Vaishnavi R. Paithankar, Pravin R. Dighe, Nirmala V. Shinde
Thiazole, one of the most common five-membered heterocyclic compounds, has a nitrogen atom at position 3 and a sulfur atom at position 1, and many of its natural and synthetic derivatives exhibit different biological behaviour. Thiazole ring substituents are modified for drug discovery and development to create new molecules with potent biological activity. To assist other researchers in developing new molecules of thiazole derivatives with more potent biological activity, this review article describes thiazole chemistry, thiazole synthesis pathways, and their biological activities. This review article aims to define the structural and biological importance of thiazoles in drug development and discovery, with recent publications on various compounds containing thiazole rings and their diverse biological activities. In particular, attention has been paid to heterocyclic scaffolds, which belong to a class of compounds with proven utility in medicinal chemistry.
{"title":"An Overview of Thiazole Derivatives and Its Biological Activities","authors":"Vaishnavi R. Paithankar, Pravin R. Dighe, Nirmala V. Shinde","doi":"10.47583/ijpsrr.2023.v82i01.007","DOIUrl":"https://doi.org/10.47583/ijpsrr.2023.v82i01.007","url":null,"abstract":"Thiazole, one of the most common five-membered heterocyclic compounds, has a nitrogen atom at position 3 and a sulfur atom at position 1, and many of its natural and synthetic derivatives exhibit different biological behaviour. Thiazole ring substituents are modified for drug discovery and development to create new molecules with potent biological activity. To assist other researchers in developing new molecules of thiazole derivatives with more potent biological activity, this review article describes thiazole chemistry, thiazole synthesis pathways, and their biological activities. This review article aims to define the structural and biological importance of thiazoles in drug development and discovery, with recent publications on various compounds containing thiazole rings and their diverse biological activities. In particular, attention has been paid to heterocyclic scaffolds, which belong to a class of compounds with proven utility in medicinal chemistry.","PeriodicalId":14255,"journal":{"name":"International Journal of Pharmaceutical Sciences Review and Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135637723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.47583/ijpsrr.2023.v82i01.002
Parthasarathi Singha, Tushar Baran Mahata, Debarpita Bhattacharya, Mousumi Dutta
Cancer is a complex multi-factorial disease of the cell. Drug discovery against cancer is ventured throughout the world especially from the nature products. Various drugs have been used in the treatment of cancer, but all of them have advantages and also different disadvantages. So, nowadays it is trying to identify different compounds from natural products which have anticancer properties. The objective(s) of this present study was to identify the anti-cancer activity of Bufo melanostictus Schneider, 1799, egg methanolic extract [TEE(M)] on the Ehrlich ascites carcinoma (EAC) cells in mice and also on human leukemic cell line (U937 and K562). Various experimental studies such as mean survival time study, U937 and K562 Cell proliferation study, bright field microscopy study, fluorescent microscopy study and MTT assay of U937 andK562 cells were performed. The results of these studies established that TEE(M) not only decreases EAC cell count but also reduces the EAC cell size and causes the apoptosis of the EAC cells. TEE(M) also decreases human myeloid leukemic cell count (U937 and K562) significantly. So, it can be said that this exact has significant anticancer effects.
{"title":"Anti-Cancer Effects of Methanolic Extract of Toad Egg on Experimental Model","authors":"Parthasarathi Singha, Tushar Baran Mahata, Debarpita Bhattacharya, Mousumi Dutta","doi":"10.47583/ijpsrr.2023.v82i01.002","DOIUrl":"https://doi.org/10.47583/ijpsrr.2023.v82i01.002","url":null,"abstract":"Cancer is a complex multi-factorial disease of the cell. Drug discovery against cancer is ventured throughout the world especially from the nature products. Various drugs have been used in the treatment of cancer, but all of them have advantages and also different disadvantages. So, nowadays it is trying to identify different compounds from natural products which have anticancer properties. The objective(s) of this present study was to identify the anti-cancer activity of Bufo melanostictus Schneider, 1799, egg methanolic extract [TEE(M)] on the Ehrlich ascites carcinoma (EAC) cells in mice and also on human leukemic cell line (U937 and K562). Various experimental studies such as mean survival time study, U937 and K562 Cell proliferation study, bright field microscopy study, fluorescent microscopy study and MTT assay of U937 andK562 cells were performed. The results of these studies established that TEE(M) not only decreases EAC cell count but also reduces the EAC cell size and causes the apoptosis of the EAC cells. TEE(M) also decreases human myeloid leukemic cell count (U937 and K562) significantly. So, it can be said that this exact has significant anticancer effects.","PeriodicalId":14255,"journal":{"name":"International Journal of Pharmaceutical Sciences Review and Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135637730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Development and Validation of A Novel HPLC Method for the Determination of Docetaxel in Pharmaceutical Dosage Forms","authors":"Shreeshail Tumbagi, Bharath Srinivasan, Pushpendu Gaurav","doi":"10.47583/ijpsrr.2023.v82i01.006","DOIUrl":"https://doi.org/10.47583/ijpsrr.2023.v82i01.006","url":null,"abstract":"","PeriodicalId":14255,"journal":{"name":"International Journal of Pharmaceutical Sciences Review and Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135637725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.47583/ijpsrr.2023.v82i01.015
Ayesha Afreen, Fariah Fathima, T. Mounika, Dr. Pittu Vishnu Priya, AVSSS Gupta
{"title":"Myelodysplastic Syndrome Can Lead to Acute Myeloid Leukemia","authors":"Ayesha Afreen, Fariah Fathima, T. Mounika, Dr. Pittu Vishnu Priya, AVSSS Gupta","doi":"10.47583/ijpsrr.2023.v82i01.015","DOIUrl":"https://doi.org/10.47583/ijpsrr.2023.v82i01.015","url":null,"abstract":"","PeriodicalId":14255,"journal":{"name":"International Journal of Pharmaceutical Sciences Review and Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135637726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.47583/ijpsrr.2023.v82i01.009
Geeta Pandey, Mahima Mahima, Trapti Gupta
Diabetes mellitus is considered as one of the top causes of morbidity among the top major causes of mortality. Numerous drugs and treatment options are available which can lower blood glucose levels but complications related to diabetes and side effects of drugs is the major challenging issue which needs to be handled. During the past few years, plant based nanoparticles have become popularized as antidiabetic agents with effective approach and minimum side effects. In the present review, various in vitro and in vivo studies based on antidiabetic potential of phyto-nanoparticles have been incorporated along with the mode of actions involved which will assist to understand the current status of phyto-nanoparticles as antidiabetic agents
{"title":"Mechanistic Approach Involved in Antidiabetic Efficiency of Plant Based Nanoparticles: A Review","authors":"Geeta Pandey, Mahima Mahima, Trapti Gupta","doi":"10.47583/ijpsrr.2023.v82i01.009","DOIUrl":"https://doi.org/10.47583/ijpsrr.2023.v82i01.009","url":null,"abstract":"Diabetes mellitus is considered as one of the top causes of morbidity among the top major causes of mortality. Numerous drugs and treatment options are available which can lower blood glucose levels but complications related to diabetes and side effects of drugs is the major challenging issue which needs to be handled. During the past few years, plant based nanoparticles have become popularized as antidiabetic agents with effective approach and minimum side effects. In the present review, various in vitro and in vivo studies based on antidiabetic potential of phyto-nanoparticles have been incorporated along with the mode of actions involved which will assist to understand the current status of phyto-nanoparticles as antidiabetic agents","PeriodicalId":14255,"journal":{"name":"International Journal of Pharmaceutical Sciences Review and Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135637727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-01DOI: 10.47583/ijpsrr.2023.v81i01.017
Niraj Kumar Mishra, Ravi Roushan, Deepak Kumar
{"title":"A Comparative Study of Efficacy and Safety of Intravenous Ondansetron and Granisetron in Management of Intra-Operative Hypotension Induced Nausea and Vomiting in Patients Undergoing Caesarean Section under Spinal Anaesthesia","authors":"Niraj Kumar Mishra, Ravi Roushan, Deepak Kumar","doi":"10.47583/ijpsrr.2023.v81i01.017","DOIUrl":"https://doi.org/10.47583/ijpsrr.2023.v81i01.017","url":null,"abstract":"","PeriodicalId":14255,"journal":{"name":"International Journal of Pharmaceutical Sciences Review and Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134997527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-01DOI: 10.47583/ijpsrr.2023.v81i01.006
Dr. Srinivasa Rao Meesala, Sanjeev Kumar, Rahul Kumar Gupta, Nikhil Kumar, Dr. Priya Bhargava, Supriya Kumari, Rupam Bharti, Sanjeev Kumar
{"title":"In-vitro Antioxidant and Anti-microbial Properties of Anthraquinones from Rhizomes of Rheum emodi against Pseudomonas aeruginosa and Staphylococcus aureus","authors":"Dr. Srinivasa Rao Meesala, Sanjeev Kumar, Rahul Kumar Gupta, Nikhil Kumar, Dr. Priya Bhargava, Supriya Kumari, Rupam Bharti, Sanjeev Kumar","doi":"10.47583/ijpsrr.2023.v81i01.006","DOIUrl":"https://doi.org/10.47583/ijpsrr.2023.v81i01.006","url":null,"abstract":"","PeriodicalId":14255,"journal":{"name":"International Journal of Pharmaceutical Sciences Review and Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134997529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-01DOI: 10.47583/ijpsrr.2023.v81i02.008
Nuruddeen Usman, Aminu A. Biambo, Aliyu Samaila, Abdilmumin Abdilmumin, Isah Maxwell O. Adibe, Igboeli NU
{"title":"Pharmaceutical Care Needs and Its Potential Impacts on Patients with Renal Impairment: A Retrospective Evaluation","authors":"Nuruddeen Usman, Aminu A. Biambo, Aliyu Samaila, Abdilmumin Abdilmumin, Isah Maxwell O. Adibe, Igboeli NU","doi":"10.47583/ijpsrr.2023.v81i02.008","DOIUrl":"https://doi.org/10.47583/ijpsrr.2023.v81i02.008","url":null,"abstract":"","PeriodicalId":14255,"journal":{"name":"International Journal of Pharmaceutical Sciences Review and Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134997837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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