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Risk factors for biometry prediction error by Barrett Universal II intraocular lens formula in Chinese patients. Barrett通用II型人工晶状体配方在中国患者生物计量预测误差的危险因素。
IF 1.9 4区 医学 Q2 OPHTHALMOLOGY Pub Date : 2025-01-18 eCollection Date: 2025-01-01 DOI: 10.18240/ijo.2025.01.08
Xu-Hao Chen, Ying Hong, Xiang-Han Ke, Si-Jia Song, Yu-Jie Cen, Chun Zhang

Aim: To investigate the influence of postoperative intraocular lens (IOL) positions on the accuracy of cataract surgery and examine the predictive factors of postoperative biometry prediction errors using the Barrett Universal II (BUII) IOL formula for calculation.

Methods: The prospective study included patients who had undergone cataract surgery performed by a single surgeon from June 2020 to April 2022. The collected data included the best-corrected visual acuity (BCVA), corneal curvature, preoperative and postoperative central anterior chamber depths (ACD), axial length (AXL), IOL power, and refractive error. BUII formula was used to calculate the IOL power. The mean absolute error (MAE) was calculated, and all the participants were divided into two groups accordingly. Independent t-tests were applied to compare the variables between groups. Logistic regression analysis was used to analyze the influence of age, AXL, corneal curvature, and preoperative and postoperative ACD on MAE.

Results: A total of 261 patients were enrolled. The 243 (93.1%) and 18 (6.9%) had postoperative MAE<1 and >1 D, respectively. The number of females was higher in patients with MAE>1 D (χ 2 = 3.833, P=0.039). The postoperative BCVA (logMAR) of patients with MAE >1 D was significantly worse (t=-2.448; P=0.025). After adjusting for gender in the logistic model, the risk of postoperative refractive errors was higher in patients with a shallow postoperative anterior chamber [odds ratio=0.346; 95% confidence interval (CI): 0.164, 0.730, P=0.005].

Conclusion: Risk factors for biometry prediction error after cataract surgery include the patient's sex and postoperative ACD. Patients with a shallow postoperative anterior chamber are prone to have refractive errors.

目的:探讨术后人工晶状体(IOL)位置对白内障手术准确性的影响,并探讨应用Barrett Universal II (BUII) IOL公式计算术后生物计量预测误差的预测因素。方法:前瞻性研究纳入了2020年6月至2022年4月期间接受单一外科医生白内障手术的患者。收集的数据包括最佳矫正视力(BCVA)、角膜曲率、术前和术后中央前房深度(ACD)、眼轴长度(AXL)、IOL度数和屈光不正。采用BUII公式计算人工晶状体度数。计算平均绝对误差(MAE),并将所有参与者相应地分为两组。采用独立t检验比较组间变量。采用Logistic回归分析年龄、AXL、角膜曲率、术前术后ACD对MAE的影响。结果:共纳入261例患者。243例(93.1%)和18例(6.9%)术后发生MAE1 D。MAE患者中女性患者较多(χ 2 = 3.833, P=0.039)。MAE患者的术后BCVA (logMAR)显著差(t=-2.448;P = 0.025)。在logistic模型中调整性别后,术后浅前房患者发生术后屈光不正的风险更高[优势比=0.346;95%置信区间(CI): 0.164, 0.730, P=0.005]。结论:白内障术后生物计量预测误差的危险因素包括患者的性别和术后ACD。术后前房浅的患者容易发生屈光不正。
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引用次数: 0
Assessing microcatheter-assisted 360-degree trabeculotomy combined with trabeculectomy for refractory glaucoma: 1-year results. 评估微导管辅助360度小梁切开术联合小梁切除术治疗难治性青光眼:1年的结果。
IF 1.9 4区 医学 Q2 OPHTHALMOLOGY Pub Date : 2025-01-18 eCollection Date: 2025-01-01 DOI: 10.18240/ijo.2025.01.11
Jia-Yin Qin, Yan Liu, Tao Wang

Aim: To evaluate the efficacy and safety of microcatheter-assisted 360-degree trabeculotomy combined with trabeculectomy (MATT-Trab) for treating refractory glaucoma.

Methods: Patients with refractory glaucoma who underwent MATT-Trab were retrospectively examined. Efficacy indicators for research statistics included the intraocular pressure (IOP) level, degree of decrease, changes in medication dosage, and success rate. Safety indicators included the best-corrected visual acuity and incidence of complications.

Results: This study comprised 31 patients, including 11 males and 20 females, with ages ranging from 8mo to 67y (mean age: 29.40±22.10y). The average postoperative IOP at 1d, 1wk, 1mo, 3mo, 6mo, 1y, and the last follow-up was significantly lower than the average preoperative IOP (31.33±9.24 mm Hg, P<0.05). The average number of postoperative medications at 1y was 0.48±1.51, which was significantly reduced compared to that used preoperatively (3.77±0.99, P=0.00). The absolute and qualified success rates were 45.16% and 83.87%, respectively. Visual acuity exhibited no statistically significant difference between the postoperative and preoperative follow-up time points, except for the first day after surgery. The most common postoperative complications were anterior chamber hemorrhage (25 cases, 86.21%) and high IOP (10 cases, 34.48%).

Conclusion: Our results indicate that MATT-Trab is effective and safe for treating refractory glaucoma.

目的:评价微导管辅助360度小梁切开术联合小梁切除术(mat - trab)治疗难治性青光眼的疗效和安全性。方法:对顽固性青光眼行mat - trab治疗的患者进行回顾性分析。研究统计的疗效指标包括眼压(IOP)水平、降低程度、用药剂量变化、成功率。安全性指标包括最佳矫正视力和并发症发生率。结果:本研究共纳入31例患者,其中男性11例,女性20例,年龄8 ~ 67岁,平均年龄29.40±22.10岁。术后1d、1w、1mo、3mo、6mo、1y及末次随访平均IOP均显著低于术前平均IOP(31.33±9.24 mm Hg, PP=0.00)。绝对成功率为45.16%,合格成功率为83.87%。除术后第1天外,术后与术前随访时间点视力差异无统计学意义。术后最常见的并发症为前房出血(25例,86.21%)和高IOP(10例,34.48%)。结论:MATT-Trab治疗难治性青光眼安全有效。
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引用次数: 0
Corneal lipid degeneration following herpes zoster ophthalmicus keratitis. 带状疱疹性眼膜炎后角膜脂质变性。
IF 1.9 4区 医学 Q2 OPHTHALMOLOGY Pub Date : 2025-01-18 eCollection Date: 2025-01-01 DOI: 10.18240/ijo.2025.01.23
Asako Kodama, Fumitaka Kobayashi
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引用次数: 0
Outcomes of a non-diffractive extended depth of focus intraocular lens in patients with well-controlled glaucoma and ocular hypertension. 控制良好的青光眼和高眼压患者非衍射扩展焦深度人工晶状体的疗效。
IF 1.9 4区 医学 Q2 OPHTHALMOLOGY Pub Date : 2025-01-18 eCollection Date: 2025-01-01 DOI: 10.18240/ijo.2025.01.09
Jia-Ru Liu, Andrei-Alexandru Szigiato, Paul Harasymowycz

Aim: To assess visual outcomes and satisfaction of a non-diffractive extended depth of focus (EDOF) intraocular lens (IOL) in individuals with ocular hypertension (OHT) and well-controlled mild glaucoma undergoing cataract surgery.

Methods: An investigator-initiated, single-center, prospective, interventional, noncomparative study conducted in Montreal, Canada. The study enrolled 31 patients (55 eyes) with OHT or mild glaucoma who received a non-diffractive EDOF IOL (Acrysof IQ Vivity). Participants underwent sequential cataract surgery with the Vivity IOL. Follow-up evaluations occurred at 1d, 1, and 3mo postoperatively, assessing uncorrected distance, intermediate, and near visual acuity. Questionnaires (QUVID: Questionnaire for visual disturbances and IOLSAT: Intraocular lens satisfaction) were administered pre and post-operatively to measure visual disturbances and spectacle independence in various lighting. Safety parameters included intraocular pressure (IOP), glaucoma medications, spherical equivalence, mean deviation and pattern standard deviation or square root of lost variance on Octopus visual field.

Results: At 1 and 3mo postoperatively, significant improvements were observed in uncorrected distance and intermediate visual acuity. Spectacle independence was enhanced for distance and intermediate vision, especially in bright light settings. Spectacle-free intermediate vision was improved even in dim lighting. Visual disturbances, particularly glare symptoms, were reduced, and there was a notable decrease in IOP and glaucoma medication burden at 3mo. There was more hazy vision postoperatively with no impact on visual acuity and visual satisfaction.

Conclusion: The non-diffractive EDOF lens improves distance and intermediate spectacle-free visual function in patients with OHT and well-controlled glaucoma. The findings highlight significant improvements in visual acuity, reduced glare, enhanced spectacle independence, and improved visual performance in different lighting conditions.

目的:评价高眼压(OHT)和控制良好的轻度青光眼患者行白内障手术后非衍射扩展焦深(EDOF)人工晶状体(IOL)的视力效果和满意度。方法:在加拿大蒙特利尔进行的一项研究者发起的、单中心、前瞻性、干预性、非比比性研究。该研究招募了31名患有OHT或轻度青光眼的患者(55只眼睛),他们接受了无衍射的EDOF IOL (acryysof IQ Vivity)。参与者接受了带活体人工晶状体的连续白内障手术。术后1、1和3个月进行随访评估,评估未矫正的距离、中间和近视力。术前和术后分别进行问卷调查(QUVID:视力障碍问卷和IOLSAT:人工晶状体满意度问卷),以测量不同光照下的视力障碍和眼镜独立性。安全参数包括眼内压(IOP)、青光眼药物、球等效性、章鱼视野的平均偏差和模式标准差或损失方差的平方根。结果:术后1、3mo未矫正距离和中间视力均有明显改善。眼镜独立性增强的距离和中间视力,特别是在明亮的光线设置。即使在昏暗的灯光下,无眼镜的中间视力也得到了改善。视力障碍,特别是眩光症状减少,并且在3个月时IOP和青光眼药物负担显著降低。术后视力模糊加重,但对视力和视觉满意度无影响。结论:无衍射EDOF晶状体可改善OHT和控制良好的青光眼患者的距离和中度无眼镜视力。研究结果强调了在不同照明条件下视觉灵敏度、眩光减少、眼镜独立性增强和视觉性能的显著改善。
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引用次数: 0
Assessing XEN microstent's one-year efficacy: independent of site variability. 评估XEN微支架一年的疗效:独立于部位变异性。
IF 1.9 4区 医学 Q2 OPHTHALMOLOGY Pub Date : 2025-01-18 eCollection Date: 2025-01-01 DOI: 10.18240/ijo.2025.01.10
Caroline Bormann, Catharina Busch, Matus Rehak, Christian Thomas Scharenberg, Focke Ziemssen, Jan Darius Unterlauft

Aim: To evaluate the short-term efficacy of XEN45 Gel Stent (XEN) implantation for primary open angle glaucoma (POAG) and pseudoexfoliation (PEX) glaucoma across two university eye clinics, aiming to assess the impact of varying center-specific protocols during the first postoperative year.

Methods: We retrospectively examined 282 patients (183 in center 1, 99 in center 2), who underwent XEN microstent implantation for uncontrolled POAG or PEX glaucoma. Parameters including intraocular pressure (IOP), IOP-lowering medication count, best corrected visual acuity (BCVA), and postoperative complications were evaluated over 12mo.

Results: Post-implantation, center 1 reported a mean IOP reduction from 25.3±7.4 to 14.1±4.7 mm Hg (P<0.01) and a decrease in IOP-lowering medications from 3.2±1.2 to 1.0±1.3 (P<0.01). Center 2 observed a similar reduction from 24.4±6.5 to 15.1±5.5 mm Hg (P<0.01) and medication decrease from 3.0±1.1 to 1.2±1.0 (P<0.01). BCVA remained stable in both cohorts. The most common complications were hypotony (center 1: 32; center 2: 20) and choroidal detachment (center 1: 22, center 2: 15), with nearly identical needling rates (40% in center 1, 41% in center 2).

Conclusion: XEN implantation yields consistent reductions in IOP and medication use across different centers using comparable surgical and postoperative treatment regime. These findings underscore XEN's short-term effectiveness and suggest standardizable outcomes regardless of exact surgical procedure or treatment differences.

目的:评估两所大学眼科诊所XEN45凝胶支架(XEN)植入术治疗原发性开角型青光眼(POAG)和假性脱落型青光眼(PEX)的短期疗效,旨在评估不同中心特异性方案在术后第一年的影响。方法:我们回顾性研究了282例(中心1 183例,中心2 99例)接受XEN微支架植入术治疗不可控POAG或PEX型青光眼的患者。随访12个月,评估眼压(IOP)、降眼压药物计数、最佳矫正视力(BCVA)及术后并发症。结果:植入术后,中心1报告平均IOP从25.3±7.4降至14.1±4.7 mm Hg (ppppp)。结论:不同中心采用相同的手术和术后治疗方案,XEN植入术的IOP和药物使用降低一致。这些发现强调了XEN的短期有效性,并提出了标准化的结果,而不考虑确切的手术程序或治疗差异。
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引用次数: 0
Femtosecond laser small incision lenticule extraction on binocularity for myopia with glasses-free 3D technique. 飞秒激光小切口晶状体摘取术治疗近视裸眼3D技术。
IF 1.9 4区 医学 Q2 OPHTHALMOLOGY Pub Date : 2025-01-18 eCollection Date: 2025-01-01 DOI: 10.18240/ijo.2025.01.15
Bing-Jie Chen, Yu-Chen Fan, Yong-Chuan Liao

Aim: To evaluate the effect of femtosecond laser small incision lenticule extraction (SMILE) on the binocular visual function in myopic patients with glasses-free three-dimensional (3D) technique.

Methods: Totally 50 myopic patients (39 females and 11 males) with SMILE were enrolled in this prospective study. The glasses-free 3D technique was used to evaluate the binocular visual function in these subjects including static stereopsis, dynamic stereopsis, foveal suppression, and binocular balance point of signal to noise ratio (s/n ratio). All subjects received measurements in 1d before operation, and 1d, 1wk, and 1mo postoperatively.

Results: Both static and dynamic stereopsis showed no significant difference after SMILE. The foveal suppression improved significantly 1wk and 1mo after SMILE (P=0.005 and P=0.007 respectively). The binocular balance point of signal to noise ratio showed a significant improvement 1d, 1wk and 1mo after SMILE for both eyes (P<0.001 for each eye respectively).

Conclusion: Glasses-free 3D technique can be used to evaluate the effect of SMILE on the binocular visual function in myopic patients perceptively, and SMILE can improve both foveal suppression and binocular imbalance in these patients.

目的:探讨飞秒激光小切口晶状体摘除术(SMILE)对裸眼三维(3D)技术近视患者双眼视功能的影响。方法:对50例SMILE近视患者(女39例,男11例)进行前瞻性研究。采用裸眼3D技术评价受试者的双眼视觉功能,包括静态立体视、动态立体视、中央凹抑制、双眼信噪比平衡点(s/n比)。所有受试者术前1d、术后1d、1周、1月均接受测量。结果:SMILE后静态立体视觉与动态立体视觉无显著差异。SMILE术后1周和1月中央凹抑制明显改善(P=0.005和P=0.007)。术后1d、1k、1mo双眼信噪比平衡点均有明显改善(p)。结论:裸眼3D技术可用于评价SMILE对近视患者双眼视觉功能的影响,SMILE可改善近视患者的中央凹抑制和双眼失衡。
{"title":"Femtosecond laser small incision lenticule extraction on binocularity for myopia with glasses-free 3D technique.","authors":"Bing-Jie Chen, Yu-Chen Fan, Yong-Chuan Liao","doi":"10.18240/ijo.2025.01.15","DOIUrl":"https://doi.org/10.18240/ijo.2025.01.15","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the effect of femtosecond laser small incision lenticule extraction (SMILE) on the binocular visual function in myopic patients with glasses-free three-dimensional (3D) technique.</p><p><strong>Methods: </strong>Totally 50 myopic patients (39 females and 11 males) with SMILE were enrolled in this prospective study. The glasses-free 3D technique was used to evaluate the binocular visual function in these subjects including static stereopsis, dynamic stereopsis, foveal suppression, and binocular balance point of signal to noise ratio (s/n ratio). All subjects received measurements in 1d before operation, and 1d, 1wk, and 1mo postoperatively.</p><p><strong>Results: </strong>Both static and dynamic stereopsis showed no significant difference after SMILE. The foveal suppression improved significantly 1wk and 1mo after SMILE (<i>P</i>=0.005 and <i>P</i>=0.007 respectively). The binocular balance point of signal to noise ratio showed a significant improvement 1d, 1wk and 1mo after SMILE for both eyes (<i>P</i><0.001 for each eye respectively).</p><p><strong>Conclusion: </strong>Glasses-free 3D technique can be used to evaluate the effect of SMILE on the binocular visual function in myopic patients perceptively, and SMILE can improve both foveal suppression and binocular imbalance in these patients.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 1","pages":"125-131"},"PeriodicalIF":1.9,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11672085/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Autophagy serves as a protective effect against inflammatory injury of oxidative stress in ARPE-19 cell. 自噬对ARPE-19细胞氧化应激炎症损伤具有保护作用。
IF 1.9 4区 医学 Q2 OPHTHALMOLOGY Pub Date : 2025-01-18 eCollection Date: 2025-01-01 DOI: 10.18240/ijo.2025.01.04
Na-Na Meng, Lei-Zhou Xia, Yi-Qing Gong, Pei-Rong Lu

Aim: To test the effect of autophagy on inflammatory damage resulting from oxidative stress in adult retinal pigment epithelial cell line (ARPE-19).

Methods: ARPE-19 cells were pretreated with 200 and 600 µmol/L hydrogen peroxide (H2O2) at various time intervals. The changes of cell morphology, cell viability, reactive oxygen species (ROS) level, autophagic activity, and the inflammatory cytokines (TNFα, IL-6, and TGFβ) were measured at baseline and after treatment with autophagy inducer rapamycin (Rapa) and suppressor wortmannin (Wort) or shATG5.

Results: The levels of ROS, cytokines (TNFα, IL-6, and TGFβ), and autophagic activity were significantly increased in ARPE-19 cells after pretreated with H2O2 (all P<0.05) and IL-10 was significantly decreased (P<0.05). By upregulating autophagy, Rapa significantly reduced oxidative stress-induced secretion of pro-inflammatory factors (TNFα and IL-6) and ROS (all P<0.05), yet elevated the production of TGFβ (P<0.05). In contrast, suppression of autophagy through Wort or ATG5 knockdown reduced cell viability, increased cell apoptotic rate, and exacerbated the generation of ROS and inflammatory cytokines (TNFα, IL-6, and TGFβ; all P<0.05).

Conclusion: Autophagy demonstrates a protective effect on ARPE-19 cell through mitigating oxidative damage and oxidative stress-induced inflammatory response. Regulation of autophagy may be a potential way for age-related macular degeneration.

目的:探讨自噬对成人视网膜色素上皮细胞系(ARPE-19)氧化应激引起的炎症损伤的影响。方法:分别用200µmol/L和600µmol/L过氧化氢(H2O2)预处理不同时间间隔的ARPE-19细胞。观察自噬诱导剂雷帕霉素(Rapa)和抑制剂wortmannin (Wort)或shATG5治疗前后细胞形态、细胞活力、活性氧(ROS)水平、自噬活性和炎症因子(TNFα、IL-6、TGFβ)的变化。结果:H2O2预处理后,ARPE-19细胞的ROS、细胞因子(TNFα、IL-6、TGFβ)水平和自噬活性均显著升高(均为ppppp)。结论:自噬通过减轻氧化损伤和氧化应激诱导的炎症反应,对ARPE-19细胞具有保护作用。自噬调节可能是老年性黄斑变性的一种潜在途径。
{"title":"Autophagy serves as a protective effect against inflammatory injury of oxidative stress in ARPE-19 cell.","authors":"Na-Na Meng, Lei-Zhou Xia, Yi-Qing Gong, Pei-Rong Lu","doi":"10.18240/ijo.2025.01.04","DOIUrl":"https://doi.org/10.18240/ijo.2025.01.04","url":null,"abstract":"<p><strong>Aim: </strong>To test the effect of autophagy on inflammatory damage resulting from oxidative stress in adult retinal pigment epithelial cell line (ARPE-19).</p><p><strong>Methods: </strong>ARPE-19 cells were pretreated with 200 and 600 µmol/L hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) at various time intervals. The changes of cell morphology, cell viability, reactive oxygen species (ROS) level, autophagic activity, and the inflammatory cytokines (TNFα, IL-6, and TGFβ) were measured at baseline and after treatment with autophagy inducer rapamycin (Rapa) and suppressor wortmannin (Wort) or shATG5.</p><p><strong>Results: </strong>The levels of ROS, cytokines (TNFα, IL-6, and TGFβ), and autophagic activity were significantly increased in ARPE-19 cells after pretreated with H<sub>2</sub>O<sub>2</sub> (all <i>P</i><0.05) and IL-10 was significantly decreased (<i>P</i><0.05). By upregulating autophagy, Rapa significantly reduced oxidative stress-induced secretion of pro-inflammatory factors (TNFα and IL-6) and ROS (all <i>P</i><0.05), yet elevated the production of TGFβ (<i>P</i><0.05). In contrast, suppression of autophagy through Wort or ATG5 knockdown reduced cell viability, increased cell apoptotic rate, and exacerbated the generation of ROS and inflammatory cytokines (TNFα, IL-6, and TGFβ; all <i>P</i><0.05).</p><p><strong>Conclusion: </strong>Autophagy demonstrates a protective effect on ARPE-19 cell through mitigating oxidative damage and oxidative stress-induced inflammatory response. Regulation of autophagy may be a potential way for age-related macular degeneration.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 1","pages":"28-38"},"PeriodicalIF":1.9,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11672099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metamorphopsia after surgery for rhegmatogenous retinal detachment. 孔源性视网膜脱离术后变形。
IF 1.9 4区 医学 Q2 OPHTHALMOLOGY Pub Date : 2025-01-18 eCollection Date: 2025-01-01 DOI: 10.18240/ijo.2025.01.21
Han-Tao Zhou, Zhong Lin

Improvements in surgical techniques have led to 90% success in the surgical repair of rhegmatogenous retinal detachment (RRD). However, anatomical reattachment of the retina does not ensure complete recovery of visual function. The incidence of metamorphopsia remains the most common postoperative complaint, from 24% to 88.6%. Currently, the risk factors of metamorphopsia are categorized into macular involvement, retinal shift, outer retinal folds, subretinal fluid, secondary epiretinal membrane, outer retinal layer damage, and surgical approach. The associations of metamorphopsia with postoperative best-corrected visual acuity and postoperative vision-related quality of life were still controversial. The most popular methods for assessment of metamorphopsia remain the Amsler grid and M-Charts. Most treatments cannot progress beyond the management of negative visual sensations, through methods such as occlusion therapy and aniseikonia-correcting spectacles. The main treatment approach involves RRD prevention and the management of risk factors that can lead to postoperative metamorphopsia after RRD repair. Additional research concerning metamorphopsia treatment, further upgrades of auxiliary inspection methods, and more accurate microstructural assessments are needed to address this common complication.

手术技术的改进使得孔源性视网膜脱离(RRD)的手术修复成功率达到90%。然而,视网膜的解剖复位并不能保证视觉功能的完全恢复。变形视的发生率仍然是最常见的术后主诉,从24%到88.6%。目前,变性视的危险因素分为黄斑受累、视网膜移位、视网膜外褶皱、视网膜下液、继发性视网膜前膜、视网膜外层损伤和手术入路。变形与术后最佳矫正视力和术后视力相关生活质量的关系仍然存在争议。最流行的评估变形的方法仍然是Amsler网格和m图。大多数治疗只能通过诸如遮挡治疗和斜视矫正眼镜等方法来控制负面视觉感觉。主要的治疗方法包括RRD的预防和RRD修复后可能导致术后变形的危险因素的管理。为了解决这一常见并发症,需要进一步研究变形视的治疗,进一步升级辅助检查方法,以及更准确的显微结构评估。
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引用次数: 0
Vitreous amyloidosis caused by Lys55Asn mutation in TTR with peripheral neuropathy onset: a case report of FAP-related complications. 由TTR中Lys55Asn突变引起的玻璃体淀粉样变性伴周围神经病变发病:1例fap相关并发症报告
IF 1.9 4区 医学 Q2 OPHTHALMOLOGY Pub Date : 2025-01-18 eCollection Date: 2025-01-01 DOI: 10.18240/ijo.2025.01.24
Yi-Wen Xue, Yi-Qin Xiao
{"title":"Vitreous amyloidosis caused by Lys55Asn mutation in TTR with peripheral neuropathy onset: a case report of FAP-related complications.","authors":"Yi-Wen Xue, Yi-Qin Xiao","doi":"10.18240/ijo.2025.01.24","DOIUrl":"https://doi.org/10.18240/ijo.2025.01.24","url":null,"abstract":"","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 1","pages":"184-186"},"PeriodicalIF":1.9,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11672084/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143004932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HMGB2 knockdown ameliorates retinal ganglion cell injury by inhibiting NLRP3 inflammasome activation after retinal ischemia. HMGB2敲低可通过抑制NLRP3炎性体激活改善视网膜缺血后视网膜神经节细胞损伤。
IF 1.9 4区 医学 Q2 OPHTHALMOLOGY Pub Date : 2025-01-18 eCollection Date: 2025-01-01 DOI: 10.18240/ijo.2025.01.05
Lin-Ping Xue, Hai-Song Feng

Aim: To explore the neuroprotective effects of high mobility group box 2 (HMGB2) knockdown on retinal ganglion cells (RGCs) in the retinal ischemia-reperfusion injury (RIRI).

Methods: Oxygen-glucose deprivation (OGD)-injured RGCs from postnatal three-day C57BL/6 mice pups and high intraocular pressure (IOP)-induced RIRI mice were used as cellular and animal models of RIRI. The expression of HMGB2 in the retina of RIRI mice and OGD-injured RGCs was detected through reverse transcription-polymerase chain reaction (RT-qPCR) and Western blotting. The effects of HMGB2 silencing on the morphological changes, RGCs survival, and cell apoptosis in mouse retinal tissues were observed through H&E staining, immunofluorescence staining with RNA-binding protein with multiple splicing (RBPMS) antibody, and TUNEL staining, respectively. RGC viability and apoptosis were examined by CCK-8 and flow cytometry assays. The levels of proteins associated with NOD-like receptor thermal protein domain associated protein 3 (NLRP3)-mediated pyroptosis [NLRP3, Caspase-1, GSDMD-N, interleukin (IL)-1β, IL-18] in vivo and in vitro were measured by Western blotting.

Results: HMGB2 protein and NLRP3 were upregulated in the retina of RIRI mice and OGD-injured RGCs (P<0.001). The retina was edematous, accompanied by disorganized cell arrangement and decreased thickness of all layers, and obvious vacuoles in ganglion cell layer. HMGB2 silencing alleviated the reduction in total retinal thickness and the severity of retinal tissue damage as well as suppressed RGC loss and retinal cell apoptosis in RIRI mice. OGD-induced RGC apoptosis was ameliorated after downregulation of HMGB2 in vitro. Intravitreal injection of the AAV-sh-HMGB2 and si-HMGB2 resulted in significantly decrease of NLRP3, Caspase-1, GSDMD-N, IL-1β, and IL-18 protein levels in the retinal tissues of RIRI mice and OGD-injured RGCs, respectively (all P<0.001).

Conclusion: HMGB2 knockdown protects against RGC apoptosis and pyroptosis after RIRI through suppressing NLRP3 inflammasome activation.

目的:探讨高迁移率组盒2 (HMGB2)敲低对视网膜缺血再灌注损伤(RIRI)视网膜神经节细胞(RGCs)的神经保护作用。方法:以出生3 d后C57BL/6小鼠幼崽氧糖剥夺(OGD)损伤的RGCs和高眼压(IOP)诱导的RIRI小鼠作为RIRI的细胞和动物模型。通过逆转录-聚合酶链反应(RT-qPCR)和Western blotting检测HMGB2在RIRI小鼠和ogd损伤rgc视网膜中的表达。分别通过H&E染色、RBPMS抗体免疫荧光染色和TUNEL染色观察HMGB2沉默对小鼠视网膜组织形态学变化、RGCs存活和细胞凋亡的影响。CCK-8和流式细胞术检测RGC细胞活力和细胞凋亡。采用Western blotting检测nod样受体热蛋白结构域相关蛋白3 (NLRP3)介导的焦亡[NLRP3, Caspase-1, GSDMD-N,白细胞介素(IL)-1β, IL-18]在体内和体外的相关蛋白水平。结果:HMGB2蛋白和NLRP3在RIRI小鼠视网膜和ogd损伤的RGC中表达上调(PHMGB2沉默减轻了RIRI小鼠视网膜总厚度的减少和视网膜组织损伤的严重程度,抑制了RGC丢失和视网膜细胞凋亡。体外下调HMGB2后,ogd诱导的RGC细胞凋亡得到改善。玻璃体内注射AAV-sh-HMGB2和si-HMGB2可显著降低RIRI小鼠和ogd损伤的RGC视网膜组织中NLRP3、Caspase-1、GSDMD-N、IL-1β和IL-18蛋白水平(均为p)。结论:HMGB2敲低可通过抑制NLRP3炎性体的激活来抑制RIRI后RGC的凋亡和焦亡。
{"title":"<i>HMGB2</i> knockdown ameliorates retinal ganglion cell injury by inhibiting NLRP3 inflammasome activation after retinal ischemia.","authors":"Lin-Ping Xue, Hai-Song Feng","doi":"10.18240/ijo.2025.01.05","DOIUrl":"https://doi.org/10.18240/ijo.2025.01.05","url":null,"abstract":"<p><strong>Aim: </strong>To explore the neuroprotective effects of high mobility group box 2 (<i>HMGB2</i>) knockdown on retinal ganglion cells (RGCs) in the retinal ischemia-reperfusion injury (RIRI).</p><p><strong>Methods: </strong>Oxygen-glucose deprivation (OGD)-injured RGCs from postnatal three-day C57BL/6 mice pups and high intraocular pressure (IOP)-induced RIRI mice were used as cellular and animal models of RIRI. The expression of HMGB2 in the retina of RIRI mice and OGD-injured RGCs was detected through reverse transcription-polymerase chain reaction (RT-qPCR) and Western blotting. The effects of <i>HMGB2</i> silencing on the morphological changes, RGCs survival, and cell apoptosis in mouse retinal tissues were observed through H&E staining, immunofluorescence staining with RNA-binding protein with multiple splicing (RBPMS) antibody, and TUNEL staining, respectively. RGC viability and apoptosis were examined by CCK-8 and flow cytometry assays. The levels of proteins associated with NOD-like receptor thermal protein domain associated protein 3 (NLRP3)-mediated pyroptosis [NLRP3, Caspase-1, GSDMD-N, interleukin (IL)-1β, IL-18] <i>in vivo</i> and <i>in vitro</i> were measured by Western blotting.</p><p><strong>Results: </strong>HMGB2 protein and NLRP3 were upregulated in the retina of RIRI mice and OGD-injured RGCs (<i>P</i><0.001). The retina was edematous, accompanied by disorganized cell arrangement and decreased thickness of all layers, and obvious vacuoles in ganglion cell layer. <i>HMGB2</i> silencing alleviated the reduction in total retinal thickness and the severity of retinal tissue damage as well as suppressed RGC loss and retinal cell apoptosis in RIRI mice. OGD-induced RGC apoptosis was ameliorated after downregulation of HMGB2 <i>in vitro</i>. Intravitreal injection of the AAV-sh-HMGB2 and si-HMGB2 resulted in significantly decrease of NLRP3, Caspase-1, GSDMD-N, IL-1β, and IL-18 protein levels in the retinal tissues of RIRI mice and OGD-injured RGCs, respectively (all <i>P</i><0.001).</p><p><strong>Conclusion: </strong><i>HMGB2</i> knockdown protects against RGC apoptosis and pyroptosis after RIRI through suppressing NLRP3 inflammasome activation.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 1","pages":"39-50"},"PeriodicalIF":1.9,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11672077/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
International journal of ophthalmology
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