首页 > 最新文献

International Journal of Urology最新文献

英文 中文
Three Decades of Change in Frequency of Sexual Intercourse and Sexual Function Among Japanese Men: A Comparative National Survey 三十年来日本男性性交频率和性功能的变化:一项比较全国调查。
IF 2.2 3区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2026-01-14 DOI: 10.1111/iju.70344
Yoshikazu Sato, Akira Tsujimura, Masato Shirai, Haruaki Sasaki, Ko Kobayashi, Hiroki Horita, Aoki Masaharu, Nobukazu Suzuki, Shinichi Hisasue, Shinichiro Fukuhara, Koji Chiba, Tsuyoshi Yoshizawa, Hikaru Tomoe, Kazunori Kimura, Eiji Kikuchi, Eri Maeda, Atsushi Nagai, Koichi Nagao, Taiji Tsukamoto, Naoya Masumori

Objective

This study aimed to examine trends in frequency of sexual intercourse and sexual function among Japanese men over the past 30 years by comparing the Nationwide Survey conducted by the Japanese Society for Sexual Medicine in 2023 with the Sapporo Survey conducted by the Department of Urology, Sapporo Medical University, in 1991.

Methods

Three domains were analyzed: sexual intercourse, penile rigidity, and morning erections in both studies. To minimize inconsistencies, definitions were standardized. The 2023 survey included 3795 men aged 20–79 years, while the 1991 survey comprised 8893 participants for sexual intercourse, 7517 for morning erections, and 3886 for penile rigidity. Case numbers differed by item in 1991 owing to incomplete responses. The 1991 survey targeted only married individuals; comparable analyses were performed using married participants extracted from the 2023 dataset.

Results

1. Sexual intercourse: Compared with the 1991 Sapporo Survey, the proportion of men reporting sexual intercourse less than once per month was significantly higher across all age groups in the 2023 Nationwide Survey, except among men in their 20s. 2. Penile rigidity: The proportion of men with insufficient penile rigidity for penetration was significantly higher in 2023 than in 1991 across all age groups except those aged ≥ 75 years. 3. Morning erections: Men reporting complete absence of morning erections were significantly more common in 2023 across all age groups.

Conclusion

Over the past three decades, Japanese men have shown substantial declines in the frequency of sexual intercourse, penile rigidity, and the frequency of morning erections, particularly in younger and middle-aged cohorts.

目的:本研究旨在通过比较日本性医学学会于2023年进行的全国调查和札幌医科大学泌尿科于1991年进行的札幌调查,来研究过去30年日本男性性交频率和性功能的变化趋势。方法:在两项研究中分析了三个领域:性交、阴茎刚性和晨起。为了尽量减少不一致,定义被标准化了。2023年的调查包括3795名年龄在20-79岁之间的男性,而1991年的调查包括8893名性交参与者,7517名早晨勃起参与者,3886名阴茎僵硬参与者。由于答复不完整,1991年的个案数目因项目而异。1991年的调查只针对已婚人士;对从2023年数据集中提取的已婚参与者进行了可比分析。结果:1。性交:与1991年札幌调查相比,2023年全国调查中,除了20多岁的男性外,所有年龄段报告每月性交少于一次的男性比例都显著高于1991年的札幌调查。阴茎硬度:2023年阴茎硬度不足以插入的男性比例显著高于1991年,年龄≥75岁的男性除外。3. 晨勃起:在2023年,所有年龄组中报告完全没有晨勃起的男性明显更常见。结论:在过去的三十年里,日本男性在性交频率、阴茎硬度和晨起频率方面都出现了大幅下降,尤其是在年轻和中年人群中。
{"title":"Three Decades of Change in Frequency of Sexual Intercourse and Sexual Function Among Japanese Men: A Comparative National Survey","authors":"Yoshikazu Sato,&nbsp;Akira Tsujimura,&nbsp;Masato Shirai,&nbsp;Haruaki Sasaki,&nbsp;Ko Kobayashi,&nbsp;Hiroki Horita,&nbsp;Aoki Masaharu,&nbsp;Nobukazu Suzuki,&nbsp;Shinichi Hisasue,&nbsp;Shinichiro Fukuhara,&nbsp;Koji Chiba,&nbsp;Tsuyoshi Yoshizawa,&nbsp;Hikaru Tomoe,&nbsp;Kazunori Kimura,&nbsp;Eiji Kikuchi,&nbsp;Eri Maeda,&nbsp;Atsushi Nagai,&nbsp;Koichi Nagao,&nbsp;Taiji Tsukamoto,&nbsp;Naoya Masumori","doi":"10.1111/iju.70344","DOIUrl":"10.1111/iju.70344","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aimed to examine trends in frequency of sexual intercourse and sexual function among Japanese men over the past 30 years by comparing the Nationwide Survey conducted by the Japanese Society for Sexual Medicine in 2023 with the Sapporo Survey conducted by the Department of Urology, Sapporo Medical University, in 1991.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Three domains were analyzed: sexual intercourse, penile rigidity, and morning erections in both studies. To minimize inconsistencies, definitions were standardized. The 2023 survey included 3795 men aged 20–79 years, while the 1991 survey comprised 8893 participants for sexual intercourse, 7517 for morning erections, and 3886 for penile rigidity. Case numbers differed by item in 1991 owing to incomplete responses. The 1991 survey targeted only married individuals; comparable analyses were performed using married participants extracted from the 2023 dataset.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>1. Sexual intercourse: Compared with the 1991 Sapporo Survey, the proportion of men reporting sexual intercourse less than once per month was significantly higher across all age groups in the 2023 Nationwide Survey, except among men in their 20s. 2. Penile rigidity: The proportion of men with insufficient penile rigidity for penetration was significantly higher in 2023 than in 1991 across all age groups except those aged ≥ 75 years. 3. Morning erections: Men reporting complete absence of morning erections were significantly more common in 2023 across all age groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Over the past three decades, Japanese men have shown substantial declines in the frequency of sexual intercourse, penile rigidity, and the frequency of morning erections, particularly in younger and middle-aged cohorts.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":"33 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145965996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial Comment on Oligometastatic Prostate and Bladder Cancer: An Integrative Narrative Review 少转移性前列腺癌和膀胱癌:一个综合的叙事评论。
IF 2.2 3区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2026-01-14 DOI: 10.1111/iju.70343
Hiroshi Hirata
{"title":"Editorial Comment on Oligometastatic Prostate and Bladder Cancer: An Integrative Narrative Review","authors":"Hiroshi Hirata","doi":"10.1111/iju.70343","DOIUrl":"10.1111/iju.70343","url":null,"abstract":"","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":"33 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145965960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial Comment on “Usefulness of the Toronto Voiding Symptom Score in the Diagnosis of Occult Tethered Cord Syndrome” 关于“多伦多排尿症状评分在隐匿性脊髓栓系综合征诊断中的作用”的评论。
IF 2.2 3区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2026-01-12 DOI: 10.1111/iju.70349
Ismail Selvi
{"title":"Editorial Comment on “Usefulness of the Toronto Voiding Symptom Score in the Diagnosis of Occult Tethered Cord Syndrome”","authors":"Ismail Selvi","doi":"10.1111/iju.70349","DOIUrl":"10.1111/iju.70349","url":null,"abstract":"","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":"33 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145952000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial Comment to “Clinical Features and Risk Factors of Enfortumab Vedotin-Induced Peripheral Neuropathy in Patients With Metastatic Urothelial Carcinoma: A Multicenter Retrospective Study (YUSHIMA Study)” 对“转移性尿路上皮癌患者的维多汀诱导周围神经病变的临床特征和危险因素:一项多中心回顾性研究(YUSHIMA研究)”的评论。
IF 2.2 3区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2026-01-11 DOI: 10.1111/iju.70351
Makito Miyake
{"title":"Editorial Comment to “Clinical Features and Risk Factors of Enfortumab Vedotin-Induced Peripheral Neuropathy in Patients With Metastatic Urothelial Carcinoma: A Multicenter Retrospective Study (YUSHIMA Study)”","authors":"Makito Miyake","doi":"10.1111/iju.70351","DOIUrl":"10.1111/iju.70351","url":null,"abstract":"","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":"33 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145951948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retrospective Analysis of Vesicourethral-Anastomosis Stricture/Urethral Stricture After Robotic-Assisted Laparoscopic Radical Prostatectomy With and Without Radiotherapy 机器人辅助腹腔镜根治性前列腺切除术后膀胱尿道吻合口狭窄/尿道狭窄的回顾性分析。
IF 2.2 3区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2026-01-11 DOI: 10.1111/iju.70339
Kinan Massouh, Katharina Leucht, Lutz Leistritz, Marc-Oliver Grimm

Background and Objective

Vesicourethral anastomotic stenosis and/or urethral stenosis (VUAS/US) is a complication of robotic-assisted radical prostatectomy (RARP) for prostate cancer. We aimed to evaluate the incidence of VUAS/US after RARP and to identify potential risk factors.

Materials and Methods

We performed a retrospective assessment of clinical records of patients with RARP as primary prostate cancer treatment (January 2011–December 2018) and investigated associations between VUAS/US formation and radiotherapy, pT-stage, tumor margins, Gleason score, nerve-sparing, and postoperative duration of bladder catheterization. Statistical analysis was performed via uni- and multivariable cox regression; risk estimation was done with the Kaplan–Meier method and log-rank test.

Results and Limitations

809 patients were included in the study. Median clinical follow-up was 61.0 months (IQR 50.0–75.0) and 175 (22%) patients received radiotherapy. VUAS and US were recorded in 19 (2.3%) and 10 (1.2%) patients, respectively. Whereas in univariable analysis radiotherapy, pT-stage ≥ pT3a, higher Gleason score, positive tumor margins, nerve-sparing, and prolonged duration of bladder catheterization were significant risk factors, in a multivariable analysis only radiotherapy (p = 0.003) and prolonged duration of bladder catheterization (p = 0.0309) proved to be independently predictive. Estimated 5-year risk of VUAS/US formation was lower without than with radiotherapy (2.1% [95% CI: 0.9–3.3] vs. 7.3% [95% CI: 3.4–11]) and with normal compared to prolonged bladder catheterization (2.6% [95% CI: 1.4–3.8] vs. 9.9% [95% CI: 2.3–18]). Retrospectivity and the limited number of events were our major limitations.

Conclusions and Clinical Implications

Low incidence of VUAS/US in RARP. Patients undergoing radiotherapy or requiring prolonged catheterization should be explicitly informed about the risk of VUAS/US and about symptoms. Also, physicians must be aware.

背景与目的:膀胱尿道吻合口狭窄和/或尿道狭窄(VUAS/US)是机器人辅助根治性前列腺切除术(RARP)治疗前列腺癌的并发症。我们的目的是评估RARP后VUAS/US的发生率,并确定潜在的危险因素。材料和方法:我们对2011年1月至2018年12月期间接受RARP治疗的原发性前列腺癌患者的临床记录进行了回顾性评估,并研究了VUAS/US形成与放疗、pt分期、肿瘤边缘、Gleason评分、神经保留和术后膀胱置管时间之间的关系。通过单变量和多变量cox回归进行统计分析;风险估计采用Kaplan-Meier法和log-rank检验。结果与局限性:809例患者纳入研究。中位临床随访为61.0个月(IQR为50.0 ~ 75.0),175例(22%)患者接受放疗。VUAS和US分别为19例(2.3%)和10例(1.2%)。在单变量分析中,放疗的pt分期≥pT3a、较高的Gleason评分、肿瘤边缘阳性、神经保留和膀胱导尿时间延长是显著的危险因素,而在多变量分析中,仅放疗(p = 0.003)和膀胱导尿时间延长(p = 0.0309)被证明是独立的预测因素。估计未接受放疗的5年VUAS/US形成的风险(2.1% [95% CI: 0.9-3.3] vs. 7.3% [95% CI: 3.4-11])和正常膀胱导尿相比(2.6% [95% CI: 1.4-3.8] vs. 9.9% [95% CI: 2.3-18])。回顾性和有限的事件数量是我们的主要限制。结论及临床意义:RARP患者VUAS/US发生率低。接受放疗或需要长时间置管的患者应明确告知VUAS/US的风险和症状。此外,医生必须意识到这一点。
{"title":"Retrospective Analysis of Vesicourethral-Anastomosis Stricture/Urethral Stricture After Robotic-Assisted Laparoscopic Radical Prostatectomy With and Without Radiotherapy","authors":"Kinan Massouh,&nbsp;Katharina Leucht,&nbsp;Lutz Leistritz,&nbsp;Marc-Oliver Grimm","doi":"10.1111/iju.70339","DOIUrl":"10.1111/iju.70339","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Objective</h3>\u0000 \u0000 <p>Vesicourethral anastomotic stenosis and/or urethral stenosis (VUAS/US) is a complication of robotic-assisted radical prostatectomy (RARP) for prostate cancer. We aimed to evaluate the incidence of VUAS/US after RARP and to identify potential risk factors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>We performed a retrospective assessment of clinical records of patients with RARP as primary prostate cancer treatment (January 2011–December 2018) and investigated associations between VUAS/US formation and radiotherapy, pT-stage, tumor margins, Gleason score, nerve-sparing, and postoperative duration of bladder catheterization. Statistical analysis was performed via uni- and multivariable cox regression; risk estimation was done with the Kaplan–Meier method and log-rank test.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results and Limitations</h3>\u0000 \u0000 <p>809 patients were included in the study. Median clinical follow-up was 61.0 months (IQR 50.0–75.0) and 175 (22%) patients received radiotherapy. VUAS and US were recorded in 19 (2.3%) and 10 (1.2%) patients, respectively. Whereas in univariable analysis radiotherapy, pT-stage ≥ pT3a, higher Gleason score, positive tumor margins, nerve-sparing, and prolonged duration of bladder catheterization were significant risk factors, in a multivariable analysis only radiotherapy (<i>p</i> = 0.003) and prolonged duration of bladder catheterization (<i>p</i> = 0.0309) proved to be independently predictive. Estimated 5-year risk of VUAS/US formation was lower without than with radiotherapy (2.1% [95% CI: 0.9–3.3] vs. 7.3% [95% CI: 3.4–11]) and with normal compared to prolonged bladder catheterization (2.6% [95% CI: 1.4–3.8] vs. 9.9% [95% CI: 2.3–18]). Retrospectivity and the limited number of events were our major limitations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions and Clinical Implications</h3>\u0000 \u0000 <p>Low incidence of VUAS/US in RARP. Patients undergoing radiotherapy or requiring prolonged catheterization should be explicitly informed about the risk of VUAS/US and about symptoms. Also, physicians must be aware.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":"33 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/iju.70339","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145951983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial Comment on (Abiraterone Acetate Triggers ER Stress-Mediated Androgen Receptor Suppression via PERK/ATF4/CHOP Signaling in Prostate Cancer) 在前列腺癌中,醋酸阿比特龙通过PERK/ATF4/CHOP信号触发内质网应激介导的雄激素受体抑制。
IF 2.2 3区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2026-01-11 DOI: 10.1111/iju.70352
Fatih Kar
{"title":"Editorial Comment on (Abiraterone Acetate Triggers ER Stress-Mediated Androgen Receptor Suppression via PERK/ATF4/CHOP Signaling in Prostate Cancer)","authors":"Fatih Kar","doi":"10.1111/iju.70352","DOIUrl":"10.1111/iju.70352","url":null,"abstract":"","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":"33 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145951994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Evolution of Prostate Multiparametric MRI and Its Application in Prostate Cancer Clinical Management 前列腺多参数MRI的发展及其在前列腺癌临床管理中的应用。
IF 2.2 3区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2026-01-07 DOI: 10.1111/iju.70338
Tsutomu Tamada, Mitsuru Takeuchi, Kazunori Moriya, Yu Ueda, Akira Yamamoto, Atsushi Higaki

Prostate multiparametric MRI (mpMRI) is an indispensable diagnostic tool in the clinical management of patients suspected of prostate cancer (PCa). This mpMRI consists of T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI), and dynamic contrast-enhanced MRI (DCE-MRI). This review first outlines the importance of preparation techniques in mpMRI examinations and the evolution, current status, and latest technologies of these imaging techniques. It then addresses the clinical applications of diffusion tensor imaging, particularly its potential in surgical strategies for radical prostatectomy. Additionally, this review addresses the issues and clinical application potential of biparametric MRI, which omits DCE-MRI, in PCa diagnosis. It also discusses countermeasures for category 3 lesions with insufficient positive rates for clinically significant PCa in the Prostate Imaging-Reporting and Data System (PI-RADS) diagnostic criteria for prostate mpMRI, as well as the current status of MRI-ultrasound fusion guided prostate targeted biopsy in clinical practice using prostate mpMRI as a guide.

前列腺多参数MRI (mpMRI)是临床诊断前列腺癌(PCa)患者不可缺少的诊断工具。该mpMRI包括t2加权成像(T2WI)、扩散加权成像(DWI)和动态对比增强MRI (DCE-MRI)。本文首先概述了制备技术在mpMRI检查中的重要性,以及这些成像技术的发展、现状和最新技术。然后讨论了弥散张量成像的临床应用,特别是它在根治性前列腺切除术的手术策略中的潜力。此外,本文综述了双参数MRI在PCa诊断中的问题和临床应用潜力,该方法忽略了DCE-MRI。讨论了前列腺mpMRI诊断标准中前列腺影像报告与数据系统(PI-RADS)诊断前列腺显著性前列腺癌阳性率不足的3类病变的对策,以及以前列腺mpMRI为指导的mri -超声融合引导前列腺靶向活检在临床实践中的现状。
{"title":"The Evolution of Prostate Multiparametric MRI and Its Application in Prostate Cancer Clinical Management","authors":"Tsutomu Tamada,&nbsp;Mitsuru Takeuchi,&nbsp;Kazunori Moriya,&nbsp;Yu Ueda,&nbsp;Akira Yamamoto,&nbsp;Atsushi Higaki","doi":"10.1111/iju.70338","DOIUrl":"10.1111/iju.70338","url":null,"abstract":"<p>Prostate multiparametric MRI (mpMRI) is an indispensable diagnostic tool in the clinical management of patients suspected of prostate cancer (PCa). This mpMRI consists of T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI), and dynamic contrast-enhanced MRI (DCE-MRI). This review first outlines the importance of preparation techniques in mpMRI examinations and the evolution, current status, and latest technologies of these imaging techniques. It then addresses the clinical applications of diffusion tensor imaging, particularly its potential in surgical strategies for radical prostatectomy. Additionally, this review addresses the issues and clinical application potential of biparametric MRI, which omits DCE-MRI, in PCa diagnosis. It also discusses countermeasures for category 3 lesions with insufficient positive rates for clinically significant PCa in the Prostate Imaging-Reporting and Data System (PI-RADS) diagnostic criteria for prostate mpMRI, as well as the current status of MRI-ultrasound fusion guided prostate targeted biopsy in clinical practice using prostate mpMRI as a guide.</p>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":"33 2","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/iju.70338","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145917445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk Assessment of Cytomegalovirus Reactivation After Kidney Transplantation Under a Universal Preemptive Strategy in the Era of Intravenous Immunoglobulin-Based Desensitization Therapy 静脉注射免疫球蛋白脱敏治疗时代普遍先发制人策略下肾移植后巨细胞病毒再激活的风险评估
IF 2.2 3区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2026-01-07 DOI: 10.1111/iju.70342
Yu Kijima, Toshihito Hirai, Shuhei Nozaki, Takafumi Yagisawa, Ayaka Saito, Kohei Unagami, Kazuya Omoto, Tomokazu Shimizu, Toshio Takagi, Hideki Ishida

Background

Cytomegalovirus (CMV) infection remains a key opportunistic complication after kidney transplantation. We evaluated risk factors for CMV reactivation in a universal preemptive strategy for the recent patient cohort including immunologically crossmatch positive high-risk recipients who underwent Intravenous Immunoglobulin (IVIG)-based desensitization with rituximab (Rit).

Methods

In this retrospective cohort study, 395 adult KTx recipients treated between 2019 and 2021 were enrolled. All 395 recipients were divided into 3 groups as follows: group 1 receiving IVIG (+)/Rit (+), n = 32 (8.1%); group 2 Rit (+) only, n = 270 (68.6%); group 3 receiving none, n = 93 (23.5%). The purpose of this study is to examine the influence of immunosuppressants including IVIG and/or Rit on CMV infection.

Results

Totally, CMV antigenemia was observed in 51 of 395 recipients (12.9%). Among them, 8 out of 32 recipients in group 1 (25.0%) showed CMV antigenemia, 29 out of 270 recipients in group 2 (10.7%), and 14 out of 93 recipients in group 3 (15.1%). There was a higher tendency of CMV antigenemia incidence in group 1, compared to groups 2 and 3, although not statistical significance. Univariate and multivariate logistic regression identified pre-transplant CMV-IgG seronegativity (OR 2.58; 95% CI 1.36–4.88; p = 0.004) and Immunological high-risk (OR 2.56; 95% CI 1.10–5.95; p = 0.038) as independent risk factors for CMV reactivation.

Conclusions

Seronegative status and immunosuppression against high immunological risk increased reactivation risk. Prophylactic treatment could be useful to prevent postoperative early complication in highly sensitized recipients using IVIG.

背景:巨细胞病毒(CMV)感染仍然是肾移植术后主要的机会性并发症。我们评估了CMV再激活的危险因素,在一个普遍的预防性策略中,最近的患者队列包括免疫交叉匹配阳性的高危受体,他们接受了基于免疫球蛋白(IVIG)的静脉注射利妥昔单抗(Rit)脱敏。方法:在这项回顾性队列研究中,纳入了2019年至2021年期间接受KTx治疗的395名成人患者。395例患者分为3组:1组接受IVIG (+)/Rit(+)治疗,n = 32例(8.1%);2组仅Rit (+), n = 270例(68.6%);第三组无治疗,n = 93(23.5%)。本研究的目的是研究免疫抑制剂包括IVIG和/或Rit对巨细胞病毒感染的影响。结果:395例受体中51例(12.9%)出现CMV抗原血症。其中,1组32例受者中有8例(25.0%)出现CMV抗原血症,2组270例受者中有29例(10.7%),3组93例受者中有14例(15.1%)。1组CMV抗原血症发生率高于2组和3组,但无统计学意义。单因素和多因素logistic回归发现移植前CMV- igg血清阴性(OR 2.58; 95% CI 1.36-4.88; p = 0.004)和免疫高危(OR 2.56; 95% CI 1.10-5.95; p = 0.038)是CMV再激活的独立危险因素。结论:血清阴性状态和免疫抑制对高免疫风险增加了再激活风险。预防性治疗可能有助于预防使用IVIG的高度敏感受者术后早期并发症。
{"title":"Risk Assessment of Cytomegalovirus Reactivation After Kidney Transplantation Under a Universal Preemptive Strategy in the Era of Intravenous Immunoglobulin-Based Desensitization Therapy","authors":"Yu Kijima,&nbsp;Toshihito Hirai,&nbsp;Shuhei Nozaki,&nbsp;Takafumi Yagisawa,&nbsp;Ayaka Saito,&nbsp;Kohei Unagami,&nbsp;Kazuya Omoto,&nbsp;Tomokazu Shimizu,&nbsp;Toshio Takagi,&nbsp;Hideki Ishida","doi":"10.1111/iju.70342","DOIUrl":"10.1111/iju.70342","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Cytomegalovirus (CMV) infection remains a key opportunistic complication after kidney transplantation. We evaluated risk factors for CMV reactivation in a universal preemptive strategy for the recent patient cohort including immunologically crossmatch positive high-risk recipients who underwent Intravenous Immunoglobulin (IVIG)-based desensitization with rituximab (Rit).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this retrospective cohort study, 395 adult KTx recipients treated between 2019 and 2021 were enrolled. All 395 recipients were divided into 3 groups as follows: group 1 receiving IVIG (+)/Rit (+), <i>n</i> = 32 (8.1%); group 2 Rit (+) only, <i>n</i> = 270 (68.6%); group 3 receiving none, <i>n</i> = 93 (23.5%). The purpose of this study is to examine the influence of immunosuppressants including IVIG and/or Rit on CMV infection.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Totally, CMV antigenemia was observed in 51 of 395 recipients (12.9%). Among them, 8 out of 32 recipients in group 1 (25.0%) showed CMV antigenemia, 29 out of 270 recipients in group 2 (10.7%), and 14 out of 93 recipients in group 3 (15.1%). There was a higher tendency of CMV antigenemia incidence in group 1, compared to groups 2 and 3, although not statistical significance. Univariate and multivariate logistic regression identified pre-transplant CMV-IgG seronegativity (OR 2.58; 95% CI 1.36–4.88; <i>p</i> = 0.004) and Immunological high-risk (OR 2.56; 95% CI 1.10–5.95; <i>p</i> = 0.038) as independent risk factors for CMV reactivation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Seronegative status and immunosuppression against high immunological risk increased reactivation risk. Prophylactic treatment could be useful to prevent postoperative early complication in highly sensitized recipients using IVIG.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":"33 2","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145917542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial Comment to “Daytime Bladder Control Status in Toddlerhood Is Associated With Subsequent Bedwetting in Preschool Years: A Nationwide Cohort Study of Over 30 000 Japanese Children” 对“幼儿期白天膀胱控制状况与学龄前后续尿床有关:一项针对3万多名日本儿童的全国性队列研究”的社论评论。
IF 2.2 3区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2025-12-29 DOI: 10.1111/iju.70333
Kenichi Kobayashi

The possibility that early-life urinary habits and developmental patterns may influence later urinary function, including the persistence of bedwetting and voiding dysfunction, has been discussed for many years [1, 2]. However, according to the International Children's Continence Society (ICCS), nocturnal enuresis (NE) is defined as urinary incontinence during sleep in children aged 5 years or older [3]. Therefore, there has been little solid data or evidence regarding urinary symptoms or nighttime wetting before this age.

In this context, the present study provides valuable and timely insights using a large-scale national cohort that offers robust and reliable data [4].

The authors examined daytime bladder control at 2.5 years of age, bedwetting at 4.5 years, and the relationship between these two factors. They found that 82.8% of children were still using diapers at 2.5 years, and that the prevalence of bedwetting at 4.5 years was 42.2%. These findings, based on high-quality longitudinal data, shed light on an important but underexplored developmental stage that precedes the conventional definition of enuresis. Moreover, the authors demonstrated that incomplete daytime bladder control at 2.5 years was associated with an increased risk of the persistence of bedwetting.

The data were drawn from the “Longitudinal Survey of Newborns in the 21st Century,” a nationwide birth cohort conducted by the Ministry of Health, Labour and Welfare in Japan, including more than 30 000 children. The use of such a large, well-constructed dataset is one of the major strengths of this study and strongly supports the reliability of its findings. As mentioned earlier, studies focusing on urinary control at this early age are extremely limited. Therefore, this study makes a highly valuable contribution simply by providing reliable data in this field.

Readers should remember that this is an observational study. The assessment of bladder control was based on diaper use, which reflects the actual use of diapers rather than a direct measurement of bladder function. The study does not address how diaper use itself might influence urinary control development. This is an important point to keep in mind when interpreting the findings.

Overall, this study provides a unique and informative perspective on early childhood urinary development. It highlights the importance of understanding how early-life bladder control may relate to later urinary symptoms, and it offers a strong foundation for future longitudinal or interventional research in this area.

The author takes full responsibility for this article.

The author declares no conflicts of interest.

This article is linked to Moriwake et al. papers. To view this article, visit https://doi.org/10.1111/iju.70288.

关于早期尿习惯和发育模式可能影响后期尿功能的可能性,包括尿床和排尿功能障碍的持续存在,已经讨论了很多年[1,2]。然而,根据国际儿童失禁协会(ICCS)的定义,夜间遗尿症(NE)是指5岁及以上儿童在睡眠期间尿失禁。因此,在这个年龄之前,很少有关于泌尿系统症状或夜间尿床的可靠数据或证据。在这种情况下,本研究通过大规模的国家队列提供了有价值和及时的见解,提供了稳健和可靠的数据bbb。研究人员在儿童2.5岁时检查了白天的膀胱控制情况,在儿童4.5岁时检查了尿床情况,以及这两个因素之间的关系。他们发现,82.8%的儿童在2.5岁时仍在使用尿布,而4.5岁时尿床的发生率为42.2%。这些发现基于高质量的纵向数据,揭示了遗尿传统定义之前一个重要但未被充分探索的发育阶段。此外,作者证明,在2.5岁时,不完全的白天膀胱控制与持续尿床的风险增加有关。这些数据来自“21世纪新生儿纵向调查”,这是日本厚生劳动省在全国范围内开展的一项出生队列调查,其中包括3万多名儿童。使用如此庞大、构造良好的数据集是本研究的主要优势之一,并有力地支持了其研究结果的可靠性。如前所述,关注这一早期尿路控制的研究非常有限。因此,本研究仅通过提供该领域的可靠数据就做出了非常有价值的贡献。读者应该记住,这是一项观察性研究。膀胱控制的评估是基于尿布的使用情况,这反映了尿布的实际使用情况,而不是直接测量膀胱功能。这项研究并没有说明使用尿布本身是如何影响尿控制的发展的。在解释研究结果时,这一点很重要,要牢记在心。总的来说,这项研究为儿童早期泌尿系统发育提供了一个独特的信息视角。它强调了了解早期膀胱控制如何与后期泌尿系统症状相关的重要性,并为该领域未来的纵向或介入性研究提供了坚实的基础。作者对这篇文章负全部责任。作者声明无利益冲突。这篇文章链接到Moriwake等人的论文。要查看本文,请访问https://doi.org/10.1111/iju.70288。
{"title":"Editorial Comment to “Daytime Bladder Control Status in Toddlerhood Is Associated With Subsequent Bedwetting in Preschool Years: A Nationwide Cohort Study of Over 30 000 Japanese Children”","authors":"Kenichi Kobayashi","doi":"10.1111/iju.70333","DOIUrl":"10.1111/iju.70333","url":null,"abstract":"<p>The possibility that early-life urinary habits and developmental patterns may influence later urinary function, including the persistence of bedwetting and voiding dysfunction, has been discussed for many years [<span>1, 2</span>]. However, according to the International Children's Continence Society (ICCS), nocturnal enuresis (NE) is defined as urinary incontinence during sleep in children aged 5 years or older [<span>3</span>]. Therefore, there has been little solid data or evidence regarding urinary symptoms or nighttime wetting before this age.</p><p>In this context, the present study provides valuable and timely insights using a large-scale national cohort that offers robust and reliable data [<span>4</span>].</p><p>The authors examined daytime bladder control at 2.5 years of age, bedwetting at 4.5 years, and the relationship between these two factors. They found that 82.8% of children were still using diapers at 2.5 years, and that the prevalence of bedwetting at 4.5 years was 42.2%. These findings, based on high-quality longitudinal data, shed light on an important but underexplored developmental stage that precedes the conventional definition of enuresis. Moreover, the authors demonstrated that incomplete daytime bladder control at 2.5 years was associated with an increased risk of the persistence of bedwetting.</p><p>The data were drawn from the “Longitudinal Survey of Newborns in the 21st Century,” a nationwide birth cohort conducted by the Ministry of Health, Labour and Welfare in Japan, including more than 30 000 children. The use of such a large, well-constructed dataset is one of the major strengths of this study and strongly supports the reliability of its findings. As mentioned earlier, studies focusing on urinary control at this early age are extremely limited. Therefore, this study makes a highly valuable contribution simply by providing reliable data in this field.</p><p>Readers should remember that this is an observational study. The assessment of bladder control was based on diaper use, which reflects the actual use of diapers rather than a direct measurement of bladder function. The study does not address how diaper use itself might influence urinary control development. This is an important point to keep in mind when interpreting the findings.</p><p>Overall, this study provides a unique and informative perspective on early childhood urinary development. It highlights the importance of understanding how early-life bladder control may relate to later urinary symptoms, and it offers a strong foundation for future longitudinal or interventional research in this area.</p><p>The author takes full responsibility for this article.</p><p>The author declares no conflicts of interest.</p><p>This article is linked to Moriwake et al. papers. To view this article, visit https://doi.org/10.1111/iju.70288.</p>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":"33 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12828297/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145856317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial Comment on: Use and Persistence of Beta-3 Adrenoceptor Agonists for the Treatment of Overactive Bladder 编辑评论:β -3肾上腺素能受体激动剂的使用和持续治疗膀胱过动症。
IF 2.2 3区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2025-12-27 DOI: 10.1111/iju.70337
Takanori Mochizuki
<p>The β3-adrenoceptor agonists mirabegron and vibegron represent important therapeutic options for patients with overactive bladder (OAB), yet clinicians often face challenges in distinguishing how best to use each agent in daily practice. The present study provides timely real-world data directly comparing these two agents at equivalent daily doses of 50 mg, offering one of the few opportunities to evaluate their effectiveness and persistence under routine clinical conditions [<span>1</span>].</p><p>A particularly notable finding is the relatively high discontinuation or switching rate observed among mirabegron users, with approximately 47.9% discontinuing the medication. The availability of vibegron as an alternative therapeutic agent likely contributed to this pattern, highlighting a prescribing dynamic that has not been previously captured in detail. The study thereby provides valuable insights into how the introduction of a second β3 agonist may influence clinical decision-making, adherence, and treatment persistence. The inclusion of sex-stratified analyses also enriches the study, offering more granular clinical information that may support individualized treatment selection.</p><p>Several randomized trials have compared mirabegron and vibegron in female OAB populations, generally demonstrating comparable overall efficacy, although vibegron may provide greater improvements in urinary frequency and urgency urinary incontinence in some cases [<span>2-4</span>]. However, although several comparative studies have focused on female patients, direct comparative evidence in male populations remains extremely limited, making the real-world male-predominant data presented in this study particularly informative.</p><p>As expected in retrospective real-world research, several limitations should be acknowledged, including potential selection bias arising from clinicians' prescribing preferences and the absence of standardized criteria for determining treatment discontinuation. Confounding factors—such as comorbidities or prior treatment exposure—may also have influenced persistence outcomes. Nevertheless, the authors provide important observational evidence supporting real-world treatment behaviors, including frequent switching from mirabegron to vibegron (40.7%) and the contribution of having multiple β3 agonist options to extended overall β3 agonist persistence.</p><p>The authors' earlier work reported favorable long-term persistence with mirabegron before vibegron became available, and the current findings likely reflect the evolving therapeutic landscape. These results illustrate how the presence of multiple β3 agonist options may improve long-term management by enabling treatment switching rather than treatment discontinuation. Such insights could help optimize OAB care, particularly given the known challenges with adherence and persistence across pharmacologic treatments for OAB.</p><p>Ultimately, while the present study does not establish supe
β3-肾上腺素能受体激动剂mirabegron和vibegron是膀胱过动症(OAB)患者的重要治疗选择,但临床医生经常面临在日常实践中区分如何最好地使用每种药物的挑战。目前的研究提供了及时的真实数据,直接比较了这两种药物在同等日剂量50mg下的疗效,为评估其在常规临床条件下的有效性和持久性提供了为数不多的机会。一个特别值得注意的发现是在mirabegron使用者中观察到相对较高的停药或转换率,大约有47.9%的人停药。vibegron作为替代治疗药物的可用性可能促成了这种模式,突出了以前未被详细捕获的处方动态。因此,该研究为引入第二种β3激动剂如何影响临床决策、依从性和治疗持久性提供了有价值的见解。纳入性别分层分析也丰富了研究内容,提供了更细粒度的临床信息,可能支持个体化治疗选择。一些随机试验比较了mirabegron和vibegron在女性OAB人群中的疗效,总体上显示出相当的总体疗效,尽管vibegron可能在某些情况下对尿频和紧急尿失禁有更大的改善[2-4]。然而,尽管有几项比较研究集中在女性患者身上,但在男性人群中的直接比较证据仍然非常有限,这使得本研究中提供的以男性为主的真实世界数据特别有用。正如在回顾性现实世界研究中所期望的那样,应该承认一些局限性,包括由临床医生的处方偏好引起的潜在选择偏差以及确定治疗停止的标准化标准的缺乏。混杂因素——如合并症或既往治疗暴露——也可能影响持久性结果。然而,作者提供了重要的观察性证据,支持现实世界的治疗行为,包括频繁地从米拉比格龙切换到维比格龙(40.7%),以及多种β3激动剂选择对延长β3激动剂整体持久性的贡献。作者早期的研究报告表明,在威比格龙出现之前,米拉比格龙的长期疗效良好,目前的研究结果可能反映了不断发展的治疗前景。这些结果说明了多种β3激动剂选择如何通过使治疗转换而不是停止治疗来改善长期管理。这些见解可以帮助优化OAB护理,特别是考虑到OAB药物治疗的依从性和持久性的已知挑战。最后,虽然目前的研究没有确定一种药物比另一种药物更优越,但它为现实世界的利用模式提供了重要的启示,并强调了mirabegron和vibegron的潜在互补作用。前瞻性随机研究——包括那些专门招募男性患者的研究——对于确认观察到的持久性差异是否反映了内在的药理学特性或处方行为至关重要。总的来说,本研究为正在进行的β3激动剂选择的讨论提供了有意义和临床相关的证据,强调了个体化治疗策略的重要性,以及对OAB患者提供多种治疗选择的价值。望月孝典:概念、写作、评论和编辑。作者声明无利益冲突。本文链接到Wada等人的论文。要查看本文,请访问https://doi.org/10.1111/iju.70309。
{"title":"Editorial Comment on: Use and Persistence of Beta-3 Adrenoceptor Agonists for the Treatment of Overactive Bladder","authors":"Takanori Mochizuki","doi":"10.1111/iju.70337","DOIUrl":"10.1111/iju.70337","url":null,"abstract":"&lt;p&gt;The β3-adrenoceptor agonists mirabegron and vibegron represent important therapeutic options for patients with overactive bladder (OAB), yet clinicians often face challenges in distinguishing how best to use each agent in daily practice. The present study provides timely real-world data directly comparing these two agents at equivalent daily doses of 50 mg, offering one of the few opportunities to evaluate their effectiveness and persistence under routine clinical conditions [&lt;span&gt;1&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;A particularly notable finding is the relatively high discontinuation or switching rate observed among mirabegron users, with approximately 47.9% discontinuing the medication. The availability of vibegron as an alternative therapeutic agent likely contributed to this pattern, highlighting a prescribing dynamic that has not been previously captured in detail. The study thereby provides valuable insights into how the introduction of a second β3 agonist may influence clinical decision-making, adherence, and treatment persistence. The inclusion of sex-stratified analyses also enriches the study, offering more granular clinical information that may support individualized treatment selection.&lt;/p&gt;&lt;p&gt;Several randomized trials have compared mirabegron and vibegron in female OAB populations, generally demonstrating comparable overall efficacy, although vibegron may provide greater improvements in urinary frequency and urgency urinary incontinence in some cases [&lt;span&gt;2-4&lt;/span&gt;]. However, although several comparative studies have focused on female patients, direct comparative evidence in male populations remains extremely limited, making the real-world male-predominant data presented in this study particularly informative.&lt;/p&gt;&lt;p&gt;As expected in retrospective real-world research, several limitations should be acknowledged, including potential selection bias arising from clinicians' prescribing preferences and the absence of standardized criteria for determining treatment discontinuation. Confounding factors—such as comorbidities or prior treatment exposure—may also have influenced persistence outcomes. Nevertheless, the authors provide important observational evidence supporting real-world treatment behaviors, including frequent switching from mirabegron to vibegron (40.7%) and the contribution of having multiple β3 agonist options to extended overall β3 agonist persistence.&lt;/p&gt;&lt;p&gt;The authors' earlier work reported favorable long-term persistence with mirabegron before vibegron became available, and the current findings likely reflect the evolving therapeutic landscape. These results illustrate how the presence of multiple β3 agonist options may improve long-term management by enabling treatment switching rather than treatment discontinuation. Such insights could help optimize OAB care, particularly given the known challenges with adherence and persistence across pharmacologic treatments for OAB.&lt;/p&gt;&lt;p&gt;Ultimately, while the present study does not establish supe","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":"33 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12828298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145846662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
International Journal of Urology
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1