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UCI Sports Nutrition Project: Performance Nutrition for Sprint and Endurance Track Cycling. UCI运动营养项目:短跑和耐力场地自行车运动营养项目。
IF 2.6 3区 医学 Q2 NUTRITION & DIETETICS Pub Date : 2025-10-23 DOI: 10.1123/ijsnem.2025-0043
Jamie Stanley, Peter Leo, Eric Haakonssen, Jill J Leckey

Track cycling is a unique discipline whereby events take place on a velodrome using fixed-gear bicycles. Events cover a spectrum of durations ranging from <11 s through to ∼60 min. Therefore, diverse and specialized physiological attributes are required to meet the specific demands of competition. Nutrition has a fundamental role in optimizing athlete performance through maintaining overall health, fueling training to develop the required physiological characteristics for success and enabling athletes to meet the energy demands of competition. This review will focus on how nutrition can be optimized to best support the training periodization and competition requirements and provide practical recommendations on fueling strategies for track cycling.

场地自行车是一项独特的运动,在场地上使用固定齿轮自行车进行比赛。事件涵盖的持续时间范围从
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引用次数: 0
UCI Sports Nutrition Project: Nutritional Periodization: Strategies to Enhance Training Adaptation and Recovery. UCI运动营养项目:营养分期:提高训练适应和恢复的策略。
IF 2.6 3区 医学 Q2 NUTRITION & DIETETICS Pub Date : 2025-10-22 DOI: 10.1123/ijsnem.2025-0073
James P Morton, Mark Hearris, Marc J Fell, Daniel J Owens, Shona Halson, Jorn Trommelen

The fundamental goal of nutrition for training is to provide the required energy and substrate to sustain the target training volume and intensity that is necessary to induce desired physiological adaptations. However, aside from fueling and recovery, it is now recognized that nutrient availability also modulates the activation of cell signaling pathways that regulate adaptations associated with both endurance and strength training. Such developments are the guiding principles underpinning "nutritional periodization" wherein energy, macronutrient, and micronutrient availability are deliberately manipulated across the microcycle, mesocycle, and macrocycle with the strategic goal to promote training adaptations, support recovery, manipulate body composition, and optimize competition performance. In addition to total "daily" nutrient intake, the elite athlete must, therefore, adjust their energy and carbohydrate intake in a meal-by-meal and day-by-day manner (i.e., carbohydrate periodization) in accordance with the energetic demands and training objectives of each specific training session. In addition to fueling (and refueling) for the work required, daily protein intake should at least be 1.6-2.1 g·kg-1·day-1 not only to account for amino acid oxidation during exercise but also, importantly, to promote tissue remodeling, notably skeletal muscle. Emerging evidence also supports the rationale for nutraceuticals to promote recovery and sleep, though the potential effect of such compounds in blunting training adaptation should also be considered. Taken together, it is increasingly clear that nutrition is a critical enabler to successful training outcomes, and as such, the sport nutritionist should be considered an integral member of an athlete's coaching and performance support team.

训练营养的基本目标是提供所需的能量和基质来维持目标训练量和强度,这是诱导所需的生理适应所必需的。然而,除了燃料和恢复,现在人们认识到营养物质的可用性也调节细胞信号通路的激活,从而调节与耐力和力量训练相关的适应性。这些发展是“营养周期化”的指导原则,其中能量、宏量营养素和微量营养素的可用性在微周期、中周期和大周期中被有意地操纵,以促进训练适应、支持恢复、操纵身体成分和优化比赛表现。因此,除了“每日”总营养摄入外,优秀运动员还必须根据每次特定训练阶段的能量需求和训练目标,以每顿饭和每天的方式(即碳水化合物周期化)调整自己的能量和碳水化合物摄入。除了为所需的工作提供燃料(和补充能量)外,每日蛋白质摄入量应至少为1.6-2.1 g·kg-1·day-1,这不仅是为了考虑运动过程中的氨基酸氧化,而且重要的是,为了促进组织重塑,尤其是骨骼肌。新出现的证据也支持营养保健品促进恢复和睡眠的基本原理,尽管这些化合物在钝化训练适应方面的潜在影响也应该考虑在内。综上所述,越来越清楚的是,营养是成功训练的关键因素,正因为如此,运动营养师应该被视为运动员教练和表现支持团队中不可或缺的一员。
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引用次数: 0
UCI Sports Nutrition Project: Competition and Training Demands, Physical Characteristics, and Nutritional Strategies for Performance in Bicycle Motorcross Race. UCI运动营养项目:自行车和摩托车越野赛的比赛和训练需求、身体特征和营养策略。
IF 2.6 3区 医学 Q2 NUTRITION & DIETETICS Pub Date : 2025-10-22 DOI: 10.1123/ijsnem.2025-0087
Eric Haakonssen, Kellie Hogan, Jamie Stanley, Kerry O'Bryan, Jill J Leckey

Bicycle motorcross racing is a unique sprint cycling discipline that takes place on a 300- to 450-m outdoor track with an 8-m start hill. A single race is 30-40 s in duration, and athletes can compete in up to seven races per day. Athletes require highly specific physiological attributes to meet the training and competition demands, and successful riders can produce high peak power outputs and demonstrate technical and tactical superiority over their opponents. Nutrition has a key role in optimizing athlete health, training adaptations, and overall athlete performance. This review will focus on the training and race demands for bicycle motorcross race and fueling strategies to support training and racing outcomes.

自行车摩托车越野赛是一项独特的冲刺自行车比赛,在300至450米的室外赛道上进行,起跑坡度为8米。单场比赛持续时间为30-40秒,运动员每天最多可以参加7场比赛。运动员需要高度特定的生理属性来满足训练和比赛的要求,成功的骑手可以产生高峰值功率输出,并表现出对对手的技术和战术优势。营养在优化运动员健康、训练适应和运动员整体表现方面起着关键作用。本文将重点讨论自行车和摩托车越野赛的训练和比赛需求,以及支持训练和比赛结果的加油策略。
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引用次数: 0
Summary of the 2025 Professionals in Nutrition for Exercise and Sport "10 Questions/10 Experts" Session-Can Everyday Foods Replace Some Ergogenic Supplements and Commercially Available Sports Foods? 2025年运动和运动营养专业人士“10个问题/10位专家”会议总结-日常食物可以取代一些人体原性补充剂和市售运动食品吗?
IF 2.6 3区 医学 Q2 NUTRITION & DIETETICS Pub Date : 2025-10-16 Print Date: 2026-01-01 DOI: 10.1123/ijsnem.2025-0161
Floris C Wardenaar, Thorben Aussieker, Eimear Dolan, Catalina Fernández-Campos, Stavros A Kavouras, Michael J Ormsbee, Eric S Rawson, Bryan Saunders, Kinta D Schott, Yasuki Sekiguchi, Louise M Burke

This article provides a recap of the 10 Questions/10 Experts session at the 2025 American College of Sports Medicine Annual Meeting. Each of the speakers considered the validity of common "myths" while providing evidence-based opinions to support or bust myths addressing the following questions: (a) Do people get enough dietary creatine from everyday foods? (b) Are nonsugar sweeteners an effective way to reduce energy intake in athletes? (c) Do beef jerky or chocolate milk provide enough leucine, making branched-chain amino acid supplementation unnecessary? (d) Can honey, applesauce, or other foods effectively replace carbohydrate gels for fueling exercise? (e) Is a homemade sports drink made from juice and a bit of salt just as effective as a commercially available sports drink? (f) Do vegetarians need to supplement carnosine and carnitine? (g) Is teff grain a rich source of iron? (h) Is coconut water a sufficient replacement for electrolyte drinks? (i) Can B vitamins influence the accuracy of urine color scoring to determine a low versus high urine concentration as a marker of hydration status? and (j) What is the impact of preexercise food-sourced calcium intake on acute bone metabolism in response to exercise? This article describes the content of each of the presentations including the most important outcomes and conclusions drawn by the presenters.

本文概述了2025年美国运动医学学院年会上的10个问题/10位专家会议。每位演讲者都考虑了常见“神话”的有效性,同时提供了基于证据的观点来支持或打破神话,解决以下问题:(a)人们是否从日常食物中获得足够的膳食肌酸?(b)非糖甜味剂是减少运动员能量摄入的有效方法吗?(c)牛肉干或巧克力牛奶是否提供足够的亮氨酸,不需要补充支链氨基酸?(d)蜂蜜、苹果酱或其他食物能有效地代替碳水化合物凝胶为运动提供能量吗?(e)用果汁加一点盐自制的运动饮料和市售的运动饮料一样有效吗?(f)素食者是否需要补充肌肽及肉毒碱?(g)苔麸是铁的丰富来源吗?(八)椰子汁是否足以取代电解质饮料?(i) B族维生素能否影响尿液颜色评分的准确性,以确定尿液浓度高低作为水合状态的标志?(j)运动前食物来源的钙摄入对运动后急性骨代谢的影响是什么?本文描述了每个演示的内容,包括演示者得出的最重要的结果和结论。
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引用次数: 0
Collagen Supplementation Augments Strength Training-Induced Gains in Tendon Size and Rate of Force Development in Elite Female Master Field Hockey Athletes. 胶原蛋白补充增强了力量训练诱导的肌腱大小和力量发展速度在优秀的女子曲棍球大师运动员。
IF 2.6 3区 医学 Q2 NUTRITION & DIETETICS Pub Date : 2025-09-23 Print Date: 2025-11-01 DOI: 10.1123/ijsnem.2025-0089
Christopher D Nulty, Robert M Erskine

We investigated the effects of 8-weeks of eccentric resistance exercise (RE) with hydrolyzed collagen supplementation on patellar tendon (PT) cross-sectional area (CSA), vastus lateralis (VL) muscle size, maximum voluntary force  (MVF), and peak rate of force development (pRFD) in international female field hockey Master athletes. Twenty-two premenopausal women (37 ± 2 years, 68.9 ± 8.0 kg, and 1.68 ± 0.04 m) were randomly assigned to collagen (COL; n = 10) and placebo (PLA; n = 12) cohorts in a triple-blind design. They completed three eccentric RE sessions per week for 8 weeks in addition to their regular hockey training. Before each RE session, participants ingested 30 g hydrolyzed COL or 32.9 g maltodextrin (PLA), together with 500 mg vitamin C. Pre- and postintervention, we assessed MVF and pRFD during a voluntary multijoint isometric muscle contraction and countermovement jump height, and VL thickness and PT CSA were measured with ultrasonography. MVF increased from 892 ± 366 to 1,011 ± 420 N (p = .020) and VL thickness increased from 21 ± 3 to 22 ± 3 mm (p = .015), with no Group × Time interactions (p > .05), whereas countermovement jump height did not change (p = .238). PT CSA increased in both groups (p < .001) but more in COL (116 ± 12 to 121 ± 13 mm2) than PLA (109 ± 22 to 111 ± 22 mm2, p = .014). Similarly, pRFD increased in both groups (p = .002) but more in COL (7.9 ± 1.3 to 10.1 ± 2.4 kN/s) than PLA (8.2 ± 2.4 to 9.6 ± 2.9 kN/s, p = .039). Therefore, hydrolyzed collagen supplementation enhanced gains in PT CSA and pRFD following 8 weeks of eccentric RE in elite female field hockey Master athletes, thus providing an effective strategy to improve physical performance in this underresearched population.

我们研究了8周偏心阻力运动(RE)和补充水解胶原蛋白对国际女子曲棍球大师运动员髌骨肌腱(PT)横截面积(CSA)、股外侧肌(VL)肌肉大小、最大随意力(MVF)和峰值力发展率(pRFD)的影响。22名绝经前妇女(37±2岁,68.9±8.0 kg, 1.68±0.04 m)在三盲设计中随机分为胶原(COL, n = 10)和安慰剂(PLA, n = 12)组。除了常规的冰球训练外,他们每周完成三次古怪的RE训练,持续8周。在每次RE之前,参与者摄入30 g水解COL或32.9 g麦芽糊精(PLA),以及500 mg维生素c。干预前和干预后,我们在自愿多关节等距肌肉收缩和反运动跳跃高度期间评估MVF和pRFD,并通过超声测量VL厚度和PT CSA。MVF从892±366 N增加到1,011±420 N (p = 0.020), VL厚度从21±3 mm增加到22±3 mm (p = 0.015),没有组×时间相互作用(p >.05),而反运动跳高没有变化(p = 0.238)。两组患者PT CSA均升高(p < 0.001),但COL组(116±12 ~ 121±13 mm2)高于PLA组(109±22 ~ 111±22 mm2, p = 0.014)。同样,两组的pRFD均升高(p = 0.002),但COL组的pRFD(7.9±1.3至10.1±2.4 kN/s)高于PLA组(8.2±2.4至9.6±2.9 kN/s, p = 0.039)。因此,在优秀的女子曲棍球大师运动员进行8周偏心RE后,补充水解胶原蛋白可以提高PT CSA和pRFD的增加,从而为改善这一研究不足的人群的身体表现提供了有效的策略。
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引用次数: 0
Nutritionally Relevant Technological Advancements in Professional Cycling. 职业自行车运动中与营养相关的技术进步。
IF 2.6 3区 医学 Q2 NUTRITION & DIETETICS Pub Date : 2025-09-10 DOI: 10.1123/ijsnem.2025-0048
Javier T Gonzalez, Simon Helleputte, Teun van Erp, Daniel Green, Tim Podlogar, Wim Derave, Asker Jeukendrup, Louise M Burke

Technological innovations can provide cyclists and their support team additional data. These data have potential to improve understanding of performance determinants and could be used to identify and tailor nutritional strategies to improve cycling performance. This potential, however, is dependent on the quality, interpretation, and practical use of the data generated. In this review, several technologies that are used or have some potential for use, in professional cycling are discussed. These include power meters, continuous glucose monitors, portable sweat and lactate analyzers, noninvasive estimation of muscle fiber typology, ultrasound for muscle glycogen concentrations and subcutaneous fat quantification, noninvasive core body temperature sensors, and portable substrate metabolism analyzers. The evidence regarding the validity of these technologies is critically evaluated, alongside a discussion of the potential rationale (or lack thereof) for their use in guiding nutritional strategies. Some of these technologies have sufficient validity and reliability to provide data of sufficient quality and, combined with appropriate rationale, can inform some nutritional strategies (e.g., energy expenditure from power meters). In contrast, other technologies either have insufficient rationale to inform a nutritional strategy or currently lack the validity and/or reliability to provide data of sufficient quality to inform nutritional strategies. Practitioners working with athletes are recommended to consider whether there is any practical value in each metric and, if so, then consider the validity and reliability of a method to measure such a metric before implementation.

技术创新可以为骑自行车者及其支持团队提供额外的数据。这些数据有可能提高对性能决定因素的理解,并可用于确定和定制营养策略,以提高循环性能。然而,这种潜力取决于所生成数据的质量、解释和实际使用。在这篇综述中,几种技术已经使用或有一些潜在的使用,在专业自行车讨论。其中包括功率计、连续血糖监测仪、便携式汗液和乳酸分析仪、无创肌肉纤维类型评估、肌糖原浓度超声和皮下脂肪定量、无创核心体温传感器和便携式底物代谢分析仪。对这些技术有效性的证据进行了严格评估,并讨论了它们在指导营养策略方面的潜在原理(或缺乏原理)。其中一些技术具有足够的有效性和可靠性,可以提供足够质量的数据,并与适当的原理相结合,可以为某些营养策略提供信息(例如,电能表的能量消耗)。相比之下,其他技术要么没有足够的理由来指导营养战略,要么目前缺乏有效性和/或可靠性,无法提供足够质量的数据来指导营养战略。建议与运动员一起工作的从业人员考虑每个指标是否有任何实用价值,如果有,则在实施之前考虑测量该指标的方法的有效性和可靠性。
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引用次数: 0
Nutrition for Mountain Biking and Cyclocross. 山地自行车和自行车越野的营养。
IF 2.6 3区 医学 Q2 NUTRITION & DIETETICS Pub Date : 2025-09-09 DOI: 10.1123/ijsnem.2025-0036
Tanja Oosthuyse, José J Muros, Mikel Zabala

The Union Cycliste Internationale recognizes several mountain biking (MTB) disciplines, including downhill, enduro, cross-country short track, cross-country Olympic, cross-country marathon, and multiday stage racing. Cyclocross is recognized as a separate cycling discipline. Both MTB and cyclocross include cycling on off-road surfaces of varying technicality on specialized bicycles purposed for the respective disciplines. The various discipline-specific racing formats and intensities dictate nutritional recommendations. High-paced race starts and high average race intensities support standard recommendations for caffeine and carbohydrate ingestion before and during racing and the adoption of recovery nutrient guidelines, tailored for each discipline. Notably, current quantification methods underestimate exercise intensity and exercise energy expenditure (EEE) in MTB and cyclocross because of the inability to quantify the additional energy cost of isometric contractions associated with bicycle handling while negotiating obstacles and dampening vibrations. Therefore, deriving EEE and target energy intake based on power measurements provide only minimum estimates, requiring a correction factor. Accordingly, minimum target energy intake should equate to the sum of power-derived EEE, +0.24 kcal·kg-1·km-1 off-road, resting metabolic rate, and an additional 0.45-fold resting metabolic rate (for nonexercise activity). Daily training nutrition based on standard guidelines is tailored by discipline, expected intensity, duration, and training EEE. Guidelines apply equally to both sexes. In addition, certain nutritional practices are suggested to support long-term bone health for MTB and cyclocross athletes.

国际自行车联盟承认几个山地自行车(MTB)项目,包括下坡、耐力、越野短道、越野奥林匹克、越野马拉松和多日阶段比赛。自行车越野赛被认为是一项独立的自行车运动。MTB和自行车越野赛都包括在不同技术的越野路面上骑专门为各自学科设计的自行车。不同学科的特定比赛形式和强度决定了营养建议。高节奏的比赛开始和高平均比赛强度支持比赛前和比赛期间咖啡因和碳水化合物摄入的标准建议,并采用针对每个项目量身定制的恢复营养指南。值得注意的是,目前的量化方法低估了MTB和自行车越野赛的运动强度和运动能量消耗(EEE),因为无法量化与自行车处理相关的等距收缩的额外能量成本,同时通过障碍物和抑制振动。因此,基于功率测量的EEE和目标能量摄入只能提供最小的估计,需要校正因子。因此,最低目标能量摄入应等于功率衍生EEE, +0.24 kcal·kg-1·km-1越野,静息代谢率和额外的0.45倍静息代谢率(非运动活动)的总和。基于标准指南的日常训练营养根据学科、预期强度、持续时间和训练EEE量身定制。指导方针对男女平等适用。此外,建议一定的营养做法,以支持长期骨骼健康的结核和自行车运动员。
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引用次数: 0
The Effects of Caffeine Mouth Rinsing During the Battery of Soccer-Specific Tests in the Trained Male Soccer Players: Fasted Versus Fed State. 在训练有素的男性足球运动员的一系列足球专项测试中,咖啡因漱口的影响:禁食与进食状态。
IF 2.6 3区 医学 Q2 NUTRITION & DIETETICS Pub Date : 2025-09-09 Print Date: 2025-11-01 DOI: 10.1123/ijsnem.2025-0040
Hossein Miraftabi, Hossein Ghorbani, Pedram Souzandeh, Erfan Berjisian, Alireza Naderi, Shima Mojtahedi, Chad Kerksick

Caffeine (CAF) mouth rinsing has been considered a practical nutritional strategy among athletes. Recent studies indicate that this nutritional strategy's efficacy may depend on the athlete's prandial state. Therefore, the main aim of the current study is to determine the effect of CAF mouth rinsing on a battery of soccer-specific tests of soccer players in fasted (FST) or fed states (FED). Thirteen male soccer players (age: 18.1 ± 0.9 years, body mass: 60.1 ± 8.4 kg, height: 174.2 ± 7.3 cm, and body mass index: 20.14 ± 2.7 kg/m2) randomly participated in a randomized, double-blind, Latin square study design. Participants completed four experimental trials while performing eight serial mouth rinses of 750-mg CAF or a taste-matched placebo (PLA) for 15 s and then immediately expectorated. Two trials commenced 2 hr after a high-carbohydrate breakfast (FED), and two trials were performed after an overnight fast (FST). Following the final mouth rinse, sprint test, countermovement jump, Yo-Yo Intermittent Recovery Test Level 1, and rating of perceived exertion were measured, respectively. There was a main effect of condition for Yo-Yo Intermittent Recovery Test Level 1 performance (p = .021), while interaction between Condition × Prandial (p = .671) and the main effect of prandial state (p = .437) was not significant for Yo-Yo Intermittent Recovery Test Level 1 (CAF-FST = 2,155 ± 484 m, PLA-FST = 1,933 ± 549 m, CAF-FED = 2,098 ± 679 m, and PLA-FED = 1,864 ± 535 m). In addition, there was no significant main effect of condition, prandial, and interaction between Condition × Prandial for the sprint test and countermovement jump and the rating of perceived exertion (all p > .5). These data suggest that CAF mouth rinsing increases intermittent running performance in soccer players. This improvement is likely to be similar in the FST and FED states.

咖啡因(CAF)漱口一直被认为是运动员的实用营养策略。最近的研究表明,这种营养策略的功效可能取决于运动员的膳食状态。因此,当前研究的主要目的是确定CAF漱口对禁食状态(FST)或进食状态(fed)的足球运动员进行的一系列足球特定测试的影响。采用随机、双盲、拉丁方研究设计,随机选取13名男性足球运动员(年龄18.1±0.9岁,体重60.1±8.4 kg,身高174.2±7.3 cm,体重指数20.14±2.7 kg/m2)。参与者完成了四项实验,同时进行了八次750毫克CAF或口味匹配安慰剂(PLA)的连续漱口,持续15秒,然后立即咳痰。两项试验在高碳水化合物早餐(FED)后2小时开始,两项试验在一夜禁食(FST)后进行。在最后一次漱口后,分别进行冲刺测试、反动作跳跃测试、溜溜球间歇恢复测试1级和感知用力评分。溜溜球间歇恢复测试1级表现中,状态存在主效应(p = 0.021),而溜溜球间歇恢复测试1级(caf1 - fst = 2,155±484 m, pla1 - fst = 1,933±549 m, caf1 - fed = 2,098±679 m, pla1 - fed = 1,864±535 m)中,状态×膳食状态与膳食状态主效应(p = 0.671)的交互作用(p = 0.437)不显著。此外,条件、膳食和条件×膳食对短跑和反动作跳跃测试的交互作用对运动知觉评分没有显著的主影响(均p < 0.05)。这些数据表明,CAF漱口水可以提高足球运动员的间歇性跑步表现。这种改善在FST和美联储的州可能是类似的。
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引用次数: 0
Acute Exercise Effects on Appetite and Energy Intake in People Living With Overweight and Obesity: A Systematic Review and Meta-Analysis. 急性运动对超重和肥胖人群食欲和能量摄入的影响:一项系统综述和荟萃分析
IF 2.6 3区 医学 Q2 NUTRITION & DIETETICS Pub Date : 2025-09-04 Print Date: 2025-11-01 DOI: 10.1123/ijsnem.2025-0078
Nan Li, Min Wu, Yanchun Li

Overweight and obesity are associated with dysregulation of appetite-related hormones and altered energy intake. Exercise has been proposed as a strategy to modulate appetite and support weight management. A comprehensive search of databases, including Web of Science, PubMed, Scopus, Google Scholar, ScienceDirect, Academic Search Premier, and EBSCOHost, identified 19 studies (34 trials) for inclusion. Using a random-effects model, we calculated effect sizes (ES) for hormone concentration, appetite perception, and energy intake. Acute exercise exerted a moderate suppressive effect on acylated ghrelin (ES = -0.73) and a moderate, nonsignificant effect on insulin (ES = -0.55). A large but nonsignificant increase was observed for glucagon-like peptide-1 (ES = 3.96), while peptide YY showed a small, nonsignificant increase (ES = 0.24). Exercise significantly reduced hunger (ES = -0.35) and prospective food consumption (ES = -0.26), with minimal effects on fullness (ES = 0.16) and satiety (ES = 0.15). Significant reductions were found in both relative (ES = -0.54) and absolute energy intake (ES = -0.19). Exercise may be an effective short-term intervention for reducing appetite and energy intake among people living with overweight and obesity. Registration: PROSPERO CRD42024623903.

超重和肥胖与食欲相关激素的失调和能量摄入的改变有关。运动被认为是调节食欲和支持体重管理的一种策略。对Web of Science、PubMed、Scopus、b谷歌Scholar、ScienceDirect、Academic search Premier和EBSCOHost等数据库进行全面检索,确定了19项研究(34项试验)纳入。使用随机效应模型,我们计算了激素浓度、食欲感知和能量摄入的效应量(ES)。急性运动对乙酰化胃饥饿素有中等抑制作用(ES = -0.73),对胰岛素有中等、不显著的影响(ES = -0.55)。胰高血糖素样肽-1显著升高(ES = 3.96),肽YY显著升高(ES = 0.24)。运动显著降低饥饿感(ES = -0.35)和预期食物消耗(ES = -0.26),对饱腹感(ES = 0.16)和饱腹感(ES = 0.15)的影响最小。相对能量摄入(ES = -0.54)和绝对能量摄入(ES = -0.19)均有显著降低。运动可能是一种有效的短期干预措施,可以减少超重和肥胖人群的食欲和能量摄入。注册号:PROSPERO CRD42024623903。
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引用次数: 0
Understanding Treatment Response Heterogeneity Using Crossover Randomized Controlled Trials: A Primer for Exercise and Nutrition Scientists. 通过交叉随机对照试验了解治疗反应异质性:运动和营养科学家的入门读物。
IF 2.6 3区 医学 Q2 NUTRITION & DIETETICS Pub Date : 2025-08-28 Print Date: 2025-11-01 DOI: 10.1123/ijsnem.2025-0041
Lorenzo Lolli, Javi Gonzalez, Oliver Shannon, Bruno Spellanzon, David J Stensel, Alice E Thackray, Greg Atkinson

Crossover randomized controlled trials (RCTs) are common in exercise and nutrition sciences. Since researchers randomize participants to different sequences of the treatment and comparator/control conditions, crossover RCTs are powerful for detecting mean treatment effects under certain circumstances. We aim to review the information that can be derived from crossover RCTs about treatment response heterogeneity-a fundamental issue in precision medicine for tailoring treatments to individuals. After covering the fundamental design issues, we describe the variance components that underlie observed data. The crucial person-by-treatment variance component can be quantified from a repeated or "replicate" crossover RCT by exposing participants to multiple cycles of trial conditions. As a type of n-of-1 trial, replicate crossover RCTs have important design and statistical power considerations, which we describe. By synthesizing findings from our six published replicate crossover RCTs, we also compare various data analysis approaches. We find general agreement between these approaches, and a link between within-person consistency of response and the detection of person-by-treatment interactions. We postulate that a paired "variance comparison," for example, the Pitman-Morgan test, provides some preliminary information regarding response heterogeneity from a typical single-cycle crossover RCT. Nevertheless, underlying assumptions are critical, rendering these comparisons as merely exploratory until an n-of-1 or replicate crossover RCT is undertaken. Multiple-cycle n-of-1 trials and replicate crossover RCTs are underused but are informative for treatment response heterogeneity. However, these trials are still only one component of the process for predicting individual magnitude of response from any personal traits, which is the "holy grail" of personalized treatment.

交叉随机对照试验(rct)在运动和营养科学中很常见。由于研究人员将参与者随机分配到不同的治疗序列和比较/对照条件中,交叉随机对照试验对于检测特定情况下的平均治疗效果非常有效。我们的目的是回顾从交叉随机对照试验中获得的关于治疗反应异质性的信息,这是精准医学中针对个体定制治疗的一个基本问题。在讨论了基本的设计问题之后,我们将描述观测数据背后的方差成分。通过将参与者暴露于多个试验条件周期,可以从重复或“复制”交叉RCT中量化关键的治疗差异成分。作为一种n-of-1试验,重复交叉随机对照试验具有重要的设计和统计功效考虑,我们将对此进行描述。通过综合我们发表的六个重复交叉随机对照试验的结果,我们还比较了各种数据分析方法。我们发现这些方法之间普遍一致,并且在人的反应一致性和检测人与治疗的相互作用之间存在联系。我们假设配对的“方差比较”,例如Pitman-Morgan检验,提供了一些关于典型单周期交叉RCT反应异质性的初步信息。然而,潜在的假设是至关重要的,使得这些比较仅仅是探索性的,直到进行n-of-1或重复交叉RCT。多周期n-of-1试验和重复交叉随机对照试验未得到充分利用,但对治疗反应异质性提供了信息。然而,这些试验仍然只是预测个体对任何个人特征的反应程度的过程的一个组成部分,这是个性化治疗的“圣杯”。
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International journal of sport nutrition and exercise metabolism
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