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2013 International Workshop on Pattern Recognition in Neuroimaging最新文献

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Utility of Partial Correlation for Characterising Brain Dynamics: MVPA-based Assessment of Regularisation and Network Selection 脑动力学特征的部分相关的效用:基于mvpa的正则化和网络选择评估
Pub Date : 2013-06-22 DOI: 10.1109/PRNI.2013.24
E. Duff, T. Makin, Sasidhar S. Madugula, Stephen M. Smith, M. Woolrich
Correlation and partial correlation are often used to provide a characterisation of the network properties of the human brain, based on functional brain imaging data. However, for partial correlation, the choice of network nodes (brain regions) and regularisation parameters is crucial and not yet well explored. Here we assess a number of approaches by calculating how each approach performs when used to discriminate different ongoing states of brain activity. We find evidence that partial correlation matrices, when estimated with appropriate regularisation, can provide a useful characterisation of brain functional connectivity.
基于功能性脑成像数据,相关性和部分相关性通常用于提供人脑网络特性的表征。然而,对于部分相关,网络节点(大脑区域)和正则化参数的选择是至关重要的,但尚未得到很好的探索。在这里,我们通过计算每个方法在区分不同的大脑活动状态时的表现来评估许多方法。我们发现部分相关矩阵的证据,当用适当的正则化估计时,可以提供有用的脑功能连接特征。
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引用次数: 8
Localizing and Comparing Weight Maps Generated from Linear Kernel Machine Learning Models 由线性核机器学习模型生成的权重图的定位和比较
Pub Date : 2013-06-22 DOI: 10.1109/PRNI.2013.40
J. Schrouff, J. Crémers, G. Garraux, Luca Baldassarre, J. Miranda, C. Phillips
Recently, machine learning models have been applied to neuroimaging data, allowing to make predictions about a variable of interest based on the pattern of activation or anatomy over a set of voxels. These pattern recognition based methods present undeniable assets over classical (univariate) techniques, by providing predictions for unseen data, as well as the weights of each voxel in the model. However, the obtained weight map cannot be thresholded to perform regionally specific inference, leading to a difficult localization of the variable of interest. In this work, we provide local averages of the weights according to regions defined by anatomical or functional atlases (e.g. Brodmann atlas). These averages can then be ranked, thereby providing a sorted list of regions that can be (to a certain extent) compared with univariate results. Furthermore, we defined a "ranking distance", allowing for the quantitative comparison between localized patterns. These concepts are illustrated with two datasets.
最近,机器学习模型已被应用于神经成像数据,允许基于一组体素的激活模式或解剖模式对感兴趣的变量进行预测。这些基于模式识别的方法通过提供对未见数据的预测以及模型中每个体素的权重,比经典(单变量)技术具有无可否认的优势。然而,获得的权重图不能被阈值化来执行区域特定的推理,导致感兴趣的变量难以定位。在这项工作中,我们根据解剖或功能地图集(例如Brodmann地图集)定义的区域提供了权重的局部平均值。然后可以对这些平均值进行排序,从而提供一个排序的区域列表,可以(在一定程度上)与单变量结果进行比较。此外,我们定义了一个“排序距离”,允许在局部模式之间进行定量比较。这些概念用两个数据集来说明。
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引用次数: 37
Prediction of Second Neurological Attack in Patients with Clinically Isolated Syndrome Using Support Vector Machines 应用支持向量机预测临床孤立综合征患者神经系统二次发作
Pub Date : 2013-06-22 DOI: 10.1109/PRNI.2013.30
Viktor Wottschel, O. Ciccarelli, D. Chard, David H. Miller, D. Alexander
The aim of this study is to predict the conversion from clinically isolated syndrome to clinically definite multiple sclerosis using support vector machines. The two groups of converters and non-converters are classified using features that were calculated from baseline data of 73 patients. The data consists of standard magnetic resonance images, binary lesion masks, and clinical and demographic information. 15 features were calculated and all combinations of them were iteratively tested for their predictive capacity using polynomial kernels and radial basis functions with leave-one-out cross-validation. The accuracy of this prediction is up to 86.4% with a sensitivity and specificity in the same range indicating that this is a feasible approach for the prediction of a second clinical attack in patients with clinically isolated syndromes, and that the chosen features are appropriate. The two features gender and location of onset lesions have been used in all feature combinations leading to a high accuracy suggesting that they are highly predictive. However, it is necessary to add supporting features to maximise the accuracy.
本研究的目的是利用支持向量机预测从临床孤立综合征到临床明确多发性硬化症的转化。根据73例患者的基线数据计算出的特征,将转换者和非转换者分为两组。数据包括标准磁共振图像、二值病变掩模以及临床和人口统计信息。计算了15个特征,并使用多项式核函数和径向基函数迭代测试了所有特征组合的预测能力,并进行了留一交叉验证。该预测的准确率高达86.4%,敏感性和特异性在相同的范围内,表明该方法对于临床孤立综合征患者的第二次临床发作预测是可行的,并且所选择的特征是合适的。这两个特征的性别和发病病变的位置已被用于所有的特征组合,导致高精度,表明他们是高度预测。然而,有必要添加支持功能以最大限度地提高准确性。
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引用次数: 2
Brain Decoding via Graph Kernels 通过图核进行大脑解码
Pub Date : 2013-06-22 DOI: 10.1109/PRNI.2013.43
Sandro Vega-Pons, P. Avesani
An emergent trend in data analysis of functional brain recordings is based on multivariate pattern recognition. Unlike univariate approaches, it is designed as a prediction task by decoding the brain state. fMRI brain decoding is a challenging classification problem due to the noisy, redundant and spatio-temporal correlated data, where there are generally much more features than samples. The use of a classifier requires that raw data is mapped into n-dimensional real vectors where the structural information of the data is not taken into account. Alternative methods propose a different data representation based on a graph encoding. While graphs provide a more powerful representation, machine learning algorithms for this type of encoding become computationally intensive. The contribution of this paper is the introduction of a graph kernel with a lower computational complexity that allows taking advantage from both the representative power of graphs and the discrimination power of kernel-based classifiers such as Support Vector Machines. We provide experimental results for a discrimination task between faces and houses on a fMRI dataset. We also investigate on synthetic data, how the brain decoding task differs according to the different encodings: vectorial and graph-based. A remarkable feature of the graph approach is its capability to handle data from different subjects, without the need of any intersubject alignment. An intersubject decoding experiment is also performed for the faces versus houses problem.
基于多元模式识别的脑功能记录数据分析是一个新兴趋势。与单变量方法不同,它被设计为通过解码大脑状态来预测任务。fMRI脑解码是一个具有挑战性的分类问题,由于数据的噪声、冗余和时空相关,其中通常存在比样本更多的特征。分类器的使用要求将原始数据映射为n维实向量,其中不考虑数据的结构信息。备选方法提出了基于图编码的不同数据表示。虽然图形提供了更强大的表示,但这种编码类型的机器学习算法变得计算密集型。本文的贡献在于引入了一种计算复杂度较低的图核,可以同时利用图的代表性和基于核的分类器(如支持向量机)的识别能力。我们提供了在fMRI数据集上人脸和房屋区分任务的实验结果。在合成数据上,我们还研究了基于向量和基于图的不同编码方式对大脑解码任务的影响。图方法的一个显著特征是它能够处理来自不同主题的数据,而不需要任何主题间的对齐。对面孔与房屋问题进行了被试间解码实验。
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引用次数: 14
Creating Group-Level Functionally-Defined Atlases for Diagnostic Classification 为诊断分类创建组级功能定义地图集
Pub Date : 2013-06-22 DOI: 10.1109/PRNI.2013.17
Francisco Pereira, J. M. Walz, H. E. Çetingül, S. Sudarsky, M. Nadar, R. Prakash
In this paper we introduce a method to produce a subdivision of an anatomical atlas by taking into account the similarity of resting state functional MRI time series within anatomically-defined regions of interest. This method differs from others in that the resulting atlases are comparable across subjects, making group analyses possible. Finally, we show that the functional connectivity matrices obtained with this method can be used in a diagnostic classification task and that they enhance a classifier's ability to extract relevant information from the data, leading to more interpretable prediction models in the process.
在本文中,我们介绍了一种方法来产生解剖图谱的细分,考虑到静息状态功能MRI时间序列在解剖学定义的感兴趣区域内的相似性。这种方法与其他方法的不同之处在于,所得到的地图集在不同科目之间具有可比性,从而使群体分析成为可能。最后,我们证明了用这种方法获得的功能连接矩阵可以用于诊断分类任务,并且它们增强了分类器从数据中提取相关信息的能力,从而在此过程中产生更多可解释的预测模型。
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引用次数: 2
Descending Variance Graphs for Segmenting Neurological Structures 神经结构分割的下降方差图
Pub Date : 2013-06-22 DOI: 10.1109/PRNI.2013.52
G. Stetten, Cindy Wong, Vikas Shivaprabhu, Ada Zhang, S. Horvath, Jihang Wang, J. Galeotti, V. Gorantla, H. Aizenstein
We present a novel and relatively simple method for clustering pixels into homogeneous patches using a directed graph of edges between neighboring pixels. For a 2D image, the mean and variance of image intensity is computed within a circular region centered at each pixel. Each pixel stores its circle's mean and variance, and forms the node in a graph, with possible edges to its 4 immediate neighbors. If at least one of those neighbors has a lower variance than itself, a directed edge is formed, pointing to the neighbor with the lowest variance. Local minima in variance thus form the roots of disjoint trees, representing patches of relative homogeneity. The method works in n-dimensions and requires only a single parameter: the radius of the circular (spherical, or hyper spherical) regions used to compute variance around each pixel. Setting the intensity of all pixels within a given patch to the mean at its root pixel significantly reduces image noise while preserving anatomical structure, including location of boundaries. The patches may themselves be clustered using techniques that would be computationally too expensive if applied to the raw pixels. We demonstrate such clustering to identify fascicles in the median nerve in high-resolution 2D ultrasound images, as well as white matter hyper intensities in 3D magnetic resonance images.
我们提出了一种新颖且相对简单的方法,利用相邻像素之间的有向图边缘将像素聚类成均匀的斑块。对于二维图像,在以每个像素为中心的圆形区域内计算图像强度的均值和方差。每个像素存储其圆的均值和方差,并形成图中的节点,其4个相邻节点可能有边。如果这些邻居中至少有一个比自己的方差小,则形成一条有向边,指向方差最小的邻居。因此,局部最小方差形成了不相交树的根,代表了相对均匀性的斑块。该方法适用于n维,只需要一个参数:用于计算每个像素周围方差的圆形(球面或超球面)区域的半径。将给定斑块内所有像素的强度设置为其根像素的平均值,可以显著降低图像噪声,同时保留解剖结构,包括边界的位置。如果应用于原始像素,这些补丁本身可能会使用计算成本过高的技术进行聚类。我们展示了这种聚类来识别高分辨率2D超声图像中的正中神经束,以及3D磁共振图像中的白质超强度。
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引用次数: 3
Two Test Statistics for Cross-Modal Graph Community Significance 跨模态图群体显著性的两个检验统计量
Pub Date : 2013-06-22 DOI: 10.1109/PRNI.2013.27
J. Richiardi, A. Altmann, M. Greicius
Comparing and combining data from different brain imaging and non-imaging modalities is challenging, in particular due to the different dimensionalities and resolutions of the modalities. Using an abstract and expressive enough representation for the data, such as graphs, enables gainful inference of relationship between biological scales and mechanisms. Here, we propose a test for the significance of groups of graph vertices in a modality when the grouping is defined in another modality. We define test statistics that can be used to explore sub graphs of interest, and a permutation-based test. We evaluate sensitivity and specificity on synthetic graphs and a co-authorship graph. We then report neuroimaging results on functional, structural, and morphological connectivity graphs, by testing whether a gross anatomical partition yields significant communities. We also exemplify a hypothesis-driven use of the method by showing that elements of the visual system likely covary in cortical thickness and are well connected structurally.
比较和结合来自不同脑成像和非成像模式的数据是具有挑战性的,特别是由于模式的不同维度和分辨率。对数据使用足够抽象和表达的表示,例如图形,可以有效地推断生物尺度和机制之间的关系。在这里,我们提出了一个测试,当组在另一个模态中定义时,图顶点组在一个模态中的显著性。我们定义了可用于探索感兴趣的子图和基于排列的测试的测试统计。我们评估了合成图和合著图的敏感性和特异性。然后,我们报告功能,结构和形态连接图的神经成像结果,通过测试是否总解剖分区产生显著的群落。我们还举例说明了该方法的假设驱动使用,表明视觉系统的元素可能在皮质厚度上共同变化,并且在结构上连接良好。
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引用次数: 1
Antagonistic Activation Patterns Underlie Multi-functionality of the Right Temporo-Parietal Junction 拮抗激活模式是右侧颞顶交界处多功能的基础
Pub Date : 2013-06-22 DOI: 10.1109/PRNI.2013.25
D. Bzdok, R. Langner, S. Eickhoff, A. Laird, P. Fox
The right temporo-parietal junction (RTPJ) is consistently implicated in two cognitive domains - attention and social cognitions. We conducted multi-modal connectivity-based parcellation to investigate potentially separate functional modules within RTPJ implementing this cognitive dualism. Both task-constrained meta-analytic co activation mapping and task-free resting-state connectivity analysis independently identified two distinct clusters within RTPJ, subsequently characterized by network mapping and functional forward/reverse inference. The anterior cluster increased activity concomitantly with a midcingulate-motor-insular network, functionally associated with attention, and decreased activity with a parietal network, functionally associated with social cognition and introspection. The posterior cluster showed the exactly opposite association pattern. Our data thus suggest that RTPJ links two antagonistic brain networks processing external versus internal information.
右颞顶叶交界处(RTPJ)一直涉及两个认知领域-注意和社会认知。我们进行了基于多模态连接的分组,以研究RTPJ中实现这种认知二元论的潜在独立功能模块。任务约束的元分析共激活映射和无任务的静息状态连通性分析分别确定了RTPJ中两个不同的集群,随后通过网络映射和功能正向/反向推理表征。前簇活动增加与扣带中部-运动-岛叶网络同时发生,该网络在功能上与注意力相关;活动减少与顶叶网络同时发生,该网络在功能上与社会认知和内省相关。后簇显示完全相反的关联模式。因此,我们的数据表明,RTPJ连接了处理外部和内部信息的两个对立的大脑网络。
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引用次数: 0
Second Order Scattering Descriptors Predict fMRI Activity Due to Visual Textures 二阶散射描述子预测由于视觉纹理的fMRI活动
Pub Date : 2013-06-01 DOI: 10.1109/PRNI.2013.11
Michael Eickenberg, Fabian Pedregosa, M. Senoussi, Alexandre Gramfort, B. Thirion
Second layer scattering descriptors are known to provide good classification performance on natural quasi-stationary processes such as visual textures due to their sensitivity to higher order moments and continuity with respect to small deformations. In a functional Magnetic Resonance Imaging (fMRI) experiment we present visual textures to subjects and evaluate the predictive power of these descriptors with respect to the predictive power of simple contour energy - the first scattering layer. We are able to conclude not only that invariant second layer scattering coefficients better encode voxel activity, but also that well predicted voxels need not necessarily lie in known retinotopic regions.
由于对高阶矩的敏感性和相对于小变形的连续性,第二层散射描述符在视觉纹理等自然准平稳过程中提供了良好的分类性能。在功能磁共振成像(fMRI)实验中,我们向受试者展示视觉纹理,并评估这些描述符相对于简单轮廓能量-第一散射层的预测能力的预测能力。我们不仅可以得出不变的第二层散射系数更好地编码体素活动的结论,而且可以得出预测良好的体素不一定位于已知的视网膜异位区域。
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引用次数: 4
HRF Estimation Improves Sensitivity of fMRI Encoding and Decoding Models HRF估计提高了fMRI编码和解码模型的灵敏度
Pub Date : 2013-05-13 DOI: 10.1109/PRNI.2013.50
Fabian Pedregosa, Michael Eickenberg, B. Thirion, Alexandre Gramfort
Extracting activation patterns from functional Magnetic Resonance Images (fMRI) datasets remains challenging in rapid-event designs due to the inherent delay of blood oxygen level-dependent (BOLD) signal. The general linear model (GLM) allows to estimate the activation from a design matrix and a fixed hemodynamic response function (HRF). However, the HRF is known to vary substantially between subjects and brain regions. In this paper, we propose a model for jointly estimating the hemodynamic response function (HRF) and the activation patterns via a low-rank representation of task effects. This model is based on the linearity assumption behind the GLM and can be computed using standard gradient-based solvers. We use the activation patterns computed by our model as input data for encoding and decoding studies and report performance improvement in both settings.
由于血氧水平依赖性(BOLD)信号的固有延迟,从功能磁共振图像(fMRI)数据集中提取激活模式在快速事件设计中仍然具有挑战性。一般线性模型(GLM)允许从设计矩阵和固定的血流动力学响应函数(HRF)估计激活。然而,已知HRF在受试者和大脑区域之间有很大差异。在本文中,我们提出了一个通过任务效应的低秩表示来联合估计血流动力学反应函数(HRF)和激活模式的模型。该模型基于GLM背后的线性假设,可以使用标准的基于梯度的求解器进行计算。我们使用我们的模型计算的激活模式作为编码和解码研究的输入数据,并报告在这两种设置下的性能改进。
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引用次数: 9
期刊
2013 International Workshop on Pattern Recognition in Neuroimaging
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