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Epineurectomy of extracranial facial nerve trunk for non-flaccid sequelae following Bell's palsy: A single-arm trial. 针对贝尔麻痹后非弛缓性后遗症的颅外面神经干上神经切除术:单臂试验。
IF 12.5 2区 医学 Q1 SURGERY Pub Date : 2024-09-18 DOI: 10.1097/JS9.0000000000002080
Hua Zhao, Xiaomin Cai, Zhongding Zhang, Tingting Ying, Yinda Tang, Haopeng Wang, Baimiao Wang, Shiting Li

Background: Non-flaccid facial palsy sequelae manifest as sequelae following Bell's palsy. Currently, there are no effective remedies for addressing this issue. In this study, we proposed a new surgical solution, epineurectomy of the extracranial facial nerve trunk, and assessed its safety and efficacy as a potential remedy..

Methods: In this single-arm trial, adult patients with non-flaccid facial palsy sequelae were enrolled and subjected to epineurectomy of the extracranial facial nerve trunk. The primary efficacy endpoint was the Sunnybrook scores at months 12 postoperatively. The secondary endpoints included non-flaccid facial palsy sequelae symptom scores, such as facial tightness or facial stiffness, facial synkinesis, eyefissures narrowing or difficulty in opening the eyes, House-Brackmann grade scale, and Facial Disability Index.

Results: A total of 22 patients were enrolled between July 2020 and January 2021. One patient was lost to follow up. One year after surgery, the Sunnybrook score was 72.0 (63.0 - 75.0) at 12 months versus 68.0 (58.0 - 70.8) at baseline. The mean difference was -5.4 (-7.2 to -3.6). The scores of facial tightness or facial stiffness, synkinesis, eye fissures narrowing or difficulty in opening eyes were 0.0 (0.0 - 1.0), 1.0 (1.0 - 1.0), 1.0 (1.0 - 2.0) at 12 months versus 3.0 (1.3 - 3.0), 2.0 (1.0 - 2.8), 2.0 (2.0 - 3.0) at baseline, respectively. The median (IQR) values of the Facial Disability Index physical function were 92.0 (90.0 - 95.0) at months 12, and the mean difference (95% CI) was -32 (-38 to -26) compared to baseline. The mean difference (95% CI) in the Facial Disability Index social/well-being function between month 12 and baseline was -38 (-46 to -31).

Conclusions: Epineurectomy of the extracranial facial nerve trunk can effectively and safely alleviate the sequelae of non-flaccid facial palsy.

背景:非松弛性面瘫后遗症表现为贝尔麻痹后遗症。目前,还没有解决这一问题的有效方法。在这项研究中,我们提出了一种新的手术方案--颅外面神经干上神经切除术,并评估了其作为潜在补救措施的安全性和有效性:在这项单臂试验中,我们招募了非弛缓性面瘫后遗症的成年患者,并对他们进行了颅外面神经干上皮切除术。主要疗效终点是术后 12 个月的 Sunnybrook 评分。次要终点包括非弛张性面瘫后遗症症状评分,如面部紧绷或面部僵硬、面部同步运动、眼裂缩小或睁眼困难、House-Brackmann评分表和面部残疾指数:2020年7月至2021年1月期间,共有22名患者入组。一名患者失去了随访机会。术后一年,桑尼布鲁克评分在12个月时为72.0(63.0 - 75.0),而基线时为68.0(58.0 - 70.8)。平均差异为-5.4(-7.2 至-3.6)。在面部紧绷或面部僵硬、同步运动、眼裂缩小或睁眼困难方面,12 个月时的得分分别为 0.0(0.0 - 1.0)、1.0(1.0 - 1.0)、1.0(1.0 - 2.0),而基线时的得分分别为 3.0(1.3 - 3.0)、2.0(1.0 - 2.8)、2.0(2.0 - 3.0)。第 12 个月时,面部残疾指数身体功能的中位数(IQR)为 92.0(90.0 - 95.0),与基线相比,平均差异(95% CI)为-32(-38 - -26)。第12个月与基线相比,面部残疾指数社交/幸福功能的平均差异(95% CI)为-38(-46至-31):结论:颅外面神经干切除术可有效、安全地缓解非弛缓性面瘫后遗症。
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引用次数: 0
Quantitative tissue analysis reveals AK2, COL1A1, & PLG protein signatures: Targeted therapeutics for meningioma. 定量组织分析揭示了 AK2、COL1A1 和 PLG 蛋白特征:脑膜瘤的靶向疗法
IF 12.5 2区 医学 Q1 SURGERY Pub Date : 2024-09-17 DOI: 10.1097/JS9.0000000000002054
Swati Sharma, Shamjetsabam Nandibala Devi, Kirti Chauhan, M H Yashavarddhan, Poonam Gautam, Prem Prakash, Priyanka Choudhary, Satnam Singh Chhabra, Rajesh Acharya, Samir Kumar Kalra, Anshul Gupta, Sunila Jain, Nirmal Kumar Ganguly, Rashmi Rana

Background: Meningioma is the most prevalent primary intracranial brain tumor and accounts for one-third of all CNS tumors. Meningioma is known to be the most common yet life-threatening brain tumor with a higher recurrence rate. Globally, there is an increase in the healthcare burden due to meningioma and hence in its research. The present clinical approach includes surgical resection, chemotherapy, and radiation therapies to which the malignancy does not seem to respond efficiently. Targeted therapies and molecular markers provide elite patient treatment and care for individuals suffering from meningiomas as compared to conventional measures. Although there is proteomic data on meningioma the knowledge of potential biomarkers differentiating the grades is scarce. To identify the best set of biomarkers, validation of reported markers in large and independent sample cohorts in the future is necessary.

Methods: A total of 12 samples, 3 each of control (which made pool 1) Meningioma grade I (which made 2 sets: pool 2 and pool 3), and Meningioma grade II (which made pool 4) were taken for LC-MS/MS. After this, the expression of three proteins was checked by immunocytochemistry, flow cytometry, and western blotting.

Results: Protein expression was analyzed using various techniques like mass spectrometry, immunocytochemistry, flow cytometry, and western blotting. Mass spectrometry is the most commonly used standard and reliable technique for identifying and quantifying protein expression. We got three highly upregulated proteins namely AK2, COL1A1, and PLG using this technique. The biomarker potential of these proteins was further checked by ICC, western blotting, and flow cytometry. Three important proteins were found to be upregulated namely AK2 (Adenylate Kinase 2), COL1A1 (Collagen 1A1), and PLG (Plasminogen). The order of increased protein expression was control < MG grade I < MG grade II according to mass spectrometry and western blotting. In immunocytochemistry, we found that COL1A1 expression increases significantly with grades in comparison to control. Similarly, AK2 and PLG also showed little increase but not as much as COL1A1. In flow cytometry, PLG showed higher upregulation in grades than control. While AK2 and COL1A1 showed little increase in expression in grades than control. All techniques, especially mass spectrometry and western blotting presented higher expression of these proteins in grades as compared to control.

Conclusions: In the quest to find a suitable therapeutic marker, this study incorporates quantitative labeling and detection followed by flow cytometry, Immunocytochemistry, and western blotting for early diagnosis and treatment of meningioma. The article further explores the efficacy of some proteins namely AK2, COL1A1 & PLG to be the targeted molecules.

背景:脑膜瘤是最常见的原发性颅内脑肿瘤,占所有中枢神经系统肿瘤的三分之一。众所周知,脑膜瘤是最常见但威胁生命的脑肿瘤,复发率较高。在全球范围内,脑膜瘤造成的医疗负担日益加重,因此对脑膜瘤的研究也日益增多。目前的临床方法包括手术切除、化疗和放疗,但恶性肿瘤似乎对这些疗法反应不佳。与传统方法相比,靶向疗法和分子标记为脑膜瘤患者提供了精英治疗和护理。虽然有脑膜瘤的蛋白质组数据,但有关区分等级的潜在生物标志物的知识却很少。为了确定最佳的生物标志物,今后有必要在大型独立样本群中对已报告的标志物进行验证:共采集了 12 份样本,其中对照组(第 1 组)、脑膜瘤 I 级(第 2 组和第 3 组)和脑膜瘤 II 级(第 4 组)各 3 份,进行 LC-MS/MS 分析。之后,通过免疫细胞化学、流式细胞术和 Western 印迹法检测三种蛋白质的表达:结果:使用质谱、免疫细胞化学、流式细胞仪和 Western 印迹等多种技术分析了蛋白质的表达。质谱法是鉴定和量化蛋白质表达的最常用、最可靠的标准技术。我们利用这种技术获得了三个高上调蛋白,即 AK2、COL1A1 和 PLG。我们还通过 ICC、Western 印迹和流式细胞术进一步检测了这些蛋白质的生物标记潜力。结果发现,有三种重要的蛋白质表达上调,即 AK2(腺苷酸激酶 2)、COL1A1(胶原蛋白 1A1)和 PLG(血浆蛋白酶原)。根据质谱和 Western 印迹,蛋白质表达增加的顺序为对照组 < MG I 级 < MG II 级。在免疫细胞化学分析中,我们发现与对照组相比,COL1A1的表达随着等级的升高而显著增加。同样,AK2 和 PLG 也有少量增加,但没有 COL1A1 增加得多。在流式细胞术中,与对照组相比,PLG 在各等级中的上调率更高。而 AK2 和 COL1A1 在各等级中的表达比对照组几乎没有增加。与对照组相比,所有技术,尤其是质谱法和 Western 印迹法,都显示等级中这些蛋白质的表达更高:为了寻找合适的治疗标记物,本研究采用了流式细胞术、免疫细胞化学和 Western 印迹法进行定量标记和检测,用于脑膜瘤的早期诊断和治疗。文章进一步探讨了一些蛋白质(即 AK2、COL1A1 和 PLG)作为靶向分子的功效。
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引用次数: 0
Comparative analysis of characteristics, management and clinical outcome of blood blister-like aneurysms treated with flow diverter devices: a systematic review and meta-analysis of 30 studies. 使用血流分流装置治疗血泡样动脉瘤的特征、管理和临床疗效的比较分析:对 30 项研究的系统回顾和荟萃分析。
IF 12.5 2区 医学 Q1 SURGERY Pub Date : 2024-09-17 DOI: 10.1097/JS9.0000000000002072
Dianshi Jin, Zheming Zhang, Xin Su, Guoliang Li
<p><strong>Background and aim: </strong>Because of relatively little data for blood blister-like aneurysms (BBAs) treated with flow diverter (FD) devices, existing studies failed to provide comprehensive analysis for the characteristics, management, clinical outcome of the disease. Therefore, we collected and analyzed current evidence aiming to provide quantitatively pooled results for the management, complication, clinical and angiographic outcomes as well as the risk factors of prognosis of BBAs treated with FD devices.</p><p><strong>Methods: </strong>A systematic search of PubMed, SCOPUS, Cochrane Library and Web of Science up to May 1, 2024 was conducted for relevant studies. The primary outcomes were to expound the management, characteristics and clinical outcomes of BBAs treated with FD devices. The secondary outcomes were to determine the difference of characteristics and outcomes, as well as risk factors of BBAs treated with FD devices. Two reviewers assessed trial quality and extracted the data independently. All statistical analyses were performed using the standard statistical procedures provided in Review Manager 5.2 and Stata 12.0.</p><p><strong>Results: </strong>A total of 30 reports with 311 of 783 BBA patients were identified. The pooled results indicated that 76.3% BBAs located in internal carotid artery (ICA) and 85% and 84% patients experienced complete occlusion and modified Rankin scale (mRS) score 0-2 respectively at follow-up time. Female BBAs patients (69.9%) were more prevalent and 88.5% patients experienced a favorable outcome at discharge. The overall and periprocedural complications account for 16.8% and 9.1% respectively. The pooled results showed that the incidence of complete occlusion was 50% (95% CI: 31%-69%), 80% (95% CI: 67%-92%) and 84% (95% CI: 77%-91%) at immediate, short and longterm angiographic results respectively. In addition, the favorable, moderate and poor clinical outcomes evaluated with mRS were 89% (95% CI: 85%-94%), 13% (95% CI: 5%-21%), and 8% (95% CI: 3%-13%) respectively. We found that compared to moderate or poor outcomes, patients with good outcomes experienced significantly lower preoperative scores (MD -1.24; 95% CI -1.94--0.53), more complete occlusion (OR 5.17; 95% CI 1.26-21.15) and less complications (OR 0.20; 95% CI 0.08-0.47) respectively. It was observed that patients experienced a complication had higher onset Hunt-Hess scale (MD 0.49; 95% CI 0.03-0.96) and Fisher's score (MD 1.43; 95% CI 0.72-2.13) respectively. Patients with good outcomes experienced younger age (MD -5.76 years; 95% CI -11.31--0.21) and lower onset Hunt-Hess scale (MD -0.96; 95% CI -1.45--0.47) respectively.</p><p><strong>Conclusions: </strong>BBA was middle-aged female predominant and common in ICA. The majority of patients generally experienced favorable outcome with low incidence of periprocedural complications. In addition, good outcomes benefited from lower preoperative scores, more complete occlusion, less c
背景和目的:由于使用血流分流器(FD)治疗血泡样动脉瘤(BBA)的数据相对较少,现有研究未能对该疾病的特征、管理、临床结果进行全面分析。因此,我们收集并分析了现有证据,旨在对使用分流装置治疗水泡样动脉瘤的管理、并发症、临床和血管造影结果以及预后风险因素进行定量汇总:方法:对截至 2024 年 5 月 1 日的 PubMed、SCOPUS、Cochrane Library 和 Web of Science 进行了系统检索,以寻找相关研究。主要研究结果是阐述使用FD装置治疗BBA的管理、特征和临床结果。次要研究结果是确定使用 FD 设备治疗的 BBA 在特征和结果以及风险因素方面的差异。两名审稿人独立评估试验质量并提取数据。所有统计分析均使用 Review Manager 5.2 和 Stata 12.0 中提供的标准统计程序进行:共发现了 30 份报告,涉及 311 名 783 例 BBA 患者。汇总结果显示,76.3%的BBA位于颈内动脉(ICA),85%和84%的患者在随访时分别出现完全闭塞和改良Rankin量表(mRS)0-2分。BBAs患者中女性居多(69.9%),88.5%的患者出院时预后良好。总并发症和围手术期并发症分别占16.8%和9.1%。汇总结果显示,在即时、短期和长期血管造影结果中,完全闭塞的发生率分别为 50%(95% CI:31%-69%)、80%(95% CI:67%-92%)和 84%(95% CI:77%-91%)。此外,用 mRS 评估的良好、中度和不良临床结果分别为 89% (95% CI:85%-94%)、13% (95% CI:5%-21%)和 8% (95% CI:3%-13%)。我们发现,与中度或不良预后相比,预后良好的患者术前评分显著降低(MD-1.24;95% CI-1.94--0.53),闭塞更完全(OR 5.17;95% CI 1.26-21.15),并发症更少(OR 0.20;95% CI 0.08-0.47)。据观察,出现并发症的患者的 Hunt-Hess 评分(MD 0.49;95% CI 0.03-0.96)和 Fisher 评分(MD 1.43;95% CI 0.72-2.13)分别较高。结果良好的患者年龄较小(MD -5.76岁;95% CI -11.31--0.21),Hunt-Hess评分较低(MD -0.96;95% CI -1.45--0.47 ):结论:BBA以中年女性为主,常见于ICA。结论:BBA 以中年女性为主,在 ICA 中很常见,大多数患者的预后良好,围手术期并发症发生率较低。此外,较低的术前评分、较完全的闭塞、较少的并发症和较小的年龄也有利于良好的预后。较高的 Hunt-Hess 评分和 Fisher 评分可能会增加并发症的风险。未来的研究需要足够的样本量和长期的随访,以明确BBA的管理、长期疗效和风险因素。
{"title":"Comparative analysis of characteristics, management and clinical outcome of blood blister-like aneurysms treated with flow diverter devices: a systematic review and meta-analysis of 30 studies.","authors":"Dianshi Jin, Zheming Zhang, Xin Su, Guoliang Li","doi":"10.1097/JS9.0000000000002072","DOIUrl":"https://doi.org/10.1097/JS9.0000000000002072","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background and aim: &lt;/strong&gt;Because of relatively little data for blood blister-like aneurysms (BBAs) treated with flow diverter (FD) devices, existing studies failed to provide comprehensive analysis for the characteristics, management, clinical outcome of the disease. Therefore, we collected and analyzed current evidence aiming to provide quantitatively pooled results for the management, complication, clinical and angiographic outcomes as well as the risk factors of prognosis of BBAs treated with FD devices.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A systematic search of PubMed, SCOPUS, Cochrane Library and Web of Science up to May 1, 2024 was conducted for relevant studies. The primary outcomes were to expound the management, characteristics and clinical outcomes of BBAs treated with FD devices. The secondary outcomes were to determine the difference of characteristics and outcomes, as well as risk factors of BBAs treated with FD devices. Two reviewers assessed trial quality and extracted the data independently. All statistical analyses were performed using the standard statistical procedures provided in Review Manager 5.2 and Stata 12.0.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A total of 30 reports with 311 of 783 BBA patients were identified. The pooled results indicated that 76.3% BBAs located in internal carotid artery (ICA) and 85% and 84% patients experienced complete occlusion and modified Rankin scale (mRS) score 0-2 respectively at follow-up time. Female BBAs patients (69.9%) were more prevalent and 88.5% patients experienced a favorable outcome at discharge. The overall and periprocedural complications account for 16.8% and 9.1% respectively. The pooled results showed that the incidence of complete occlusion was 50% (95% CI: 31%-69%), 80% (95% CI: 67%-92%) and 84% (95% CI: 77%-91%) at immediate, short and longterm angiographic results respectively. In addition, the favorable, moderate and poor clinical outcomes evaluated with mRS were 89% (95% CI: 85%-94%), 13% (95% CI: 5%-21%), and 8% (95% CI: 3%-13%) respectively. We found that compared to moderate or poor outcomes, patients with good outcomes experienced significantly lower preoperative scores (MD -1.24; 95% CI -1.94--0.53), more complete occlusion (OR 5.17; 95% CI 1.26-21.15) and less complications (OR 0.20; 95% CI 0.08-0.47) respectively. It was observed that patients experienced a complication had higher onset Hunt-Hess scale (MD 0.49; 95% CI 0.03-0.96) and Fisher's score (MD 1.43; 95% CI 0.72-2.13) respectively. Patients with good outcomes experienced younger age (MD -5.76 years; 95% CI -11.31--0.21) and lower onset Hunt-Hess scale (MD -0.96; 95% CI -1.45--0.47) respectively.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;BBA was middle-aged female predominant and common in ICA. The majority of patients generally experienced favorable outcome with low incidence of periprocedural complications. In addition, good outcomes benefited from lower preoperative scores, more complete occlusion, less c","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":null,"pages":null},"PeriodicalIF":12.5,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142287313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the feasibility of preoperative tumor-bed boost, oncoplastic surgery, and adjuvant radiotherapy schedule in early-stage breast cancer: A phase II clinical trial. 探索早期乳腺癌术前肿瘤床增压、肿瘤整形手术和辅助放疗计划的可行性:II期临床试验。
IF 12.5 2区 医学 Q1 SURGERY Pub Date : 2024-09-12 DOI: 10.1097/JS9.0000000000002073
Hao Dong, Hao Jing, Xiang-Yu Wang, Xiang-Yi Kong, Yi-Peng Wang, Yi-Rui Zhai, Shu-Nan Che, Yi Fang, Shu-Lian Wang, Jing Wang

Background: Oncoplastic breast-conserving surgery (OBCS) improves satisfaction in patients who would fare otherwise sub-optimal cosmetic outcome, while brings challenge in tumor-bed identification during adjuvant radiotherapy. The ultra-hypofractionated breast radiotherapy further shortens treatment sessions from moderately hypofractionated regimens. To circumscribe the difficulty in tumor-bed contouring and the additional toxicity from larger boost volumes, we propose to move forward the boost session preoperatively from the adjuvant radiation part. Thus, the present study aims to evaluate the feasibility of a new treatment paradigm of preoperative primary-tumor boost before breast-conserving surgery (BCS) or OBCS followed by adjuvant ultra-hypofractionated whole-breast irradiation (u-WBRT) for patients with early-stage breast cancer.

Methods: There was a phase II study. Patients younger than 55 years old, with a biopsy confirmed mono-centric breast cancer, without lymph node involvement were enrolled. Preoperative primary-tumor boost was given by a single 10 Gy in 1 fraction, and BCS or OBCS was conducted within two weeks afterwards. Adjuvant u-WBRT (26 Gy/5.2 Gy/5 f) was given in 6 weeks postoperatively without any boost, after the full recovery from surgery. Surgical complications and patient-reported outcomes, as assessed via Breast-Q questionnaires, were documented. A propensity score matching approach was employed to identify a control group at a 1:1 ratio for BREAST-Q outcomes comparison.

Results: From May 2022 to September 2023, 36 patients were prospectively enrolled. Surgical complications were observed in 7 cases (19.4%), including 3 cases with Clavien-Dindo (CD) grade 1-2 and 4 cases with CD grade 3 complications. All but four patients (11.1%) started the planned u-WBRT within one week after the pre-defined due dates postoperatively (≤49 d). Four patients (11.1%) developed grade 2 radiodermatitis after chemotherapy initiation. Compared to the study group, the control patients reported higher scores in chest physical well-being ( P =0.045) and in their attitudes towards arm swelling ( P =0.01). No significant difference was detected in the other of domains (Satisfaction with Breasts, Sexual and Psychosocial Well-Being, and Adverse Effects of Radiation). With a median follow-up period of 9.8 months (2.4-18.9 mo), none had any sign of relapse.

Conclusion: This Phase II clinical trial confirmed the technical and safety feasibility of novel radiation schedule in patients undergoing BCS or OBCS. According to the BREAST-Q questionnaire, patients who underwent novel radiation schedules reported lower satisfaction in chest physical well-being. A randomized controlled trial is necessary to further investigate these findings. Additionally, long-term follow-up is required to assess oncological outcomes.

背景:肿瘤整形保乳手术(OBCS)提高了患者的满意度,否则他们的美容效果可能会不理想,但同时也给辅助放疗期间的肿瘤床识别带来了挑战。超低分量乳腺放疗进一步缩短了中度低分量方案的治疗疗程。为了避免肿瘤床轮廓确定的困难和更大增量带来的额外毒性,我们建议将术前增量治疗从辅助放疗部分前移。因此,本研究旨在评估早期乳腺癌患者在保乳手术(BCS)或OBCS前进行术前原发肿瘤增大,然后进行辅助超高分次全乳腺照射(u-WBRT)这一新治疗模式的可行性:这是一项 II 期研究。研究对象为年龄小于 55 岁、活检证实为单发中心型乳腺癌且无淋巴结受累的患者。术前对原发肿瘤进行单次10 Gy分次增强,术后两周内进行BCS或OBCS。术后6周,在手术完全恢复后进行辅助u-WBRT(26 Gy/5.2 Gy/5 f),不做任何增强。手术并发症和患者报告结果(通过乳房-Q问卷进行评估)均记录在案。采用倾向得分匹配法以1:1的比例确定对照组,进行BREAST-Q结果比较:结果:从 2022 年 5 月到 2023 年 9 月,共有 36 名患者进行了前瞻性注册。7例(19.4%)患者出现手术并发症,其中3例为克拉维恩-丁多(CD)1-2级并发症,4例为CD 3级并发症。除4例患者(11.1%)外,其余患者均在术后预定的到期日(≤49 d)后一周内开始了计划中的u-WBRT治疗。四名患者(11.1%)在化疗开始后出现了二级放射性皮炎。与研究组相比,对照组患者的胸部健康评分(P=0.045)和对手臂肿胀的态度评分(P=0.01)更高。在其他方面(对乳房的满意度、性和社会心理健康以及放射不良反应)没有发现明显差异。中位随访期为 9.8 个月(2.4-18.9 个月),无任何复发迹象:这项 II 期临床试验证实了在接受 BCS 或 OBCS 的患者中采用新型放射时间表在技术和安全性方面的可行性。根据 BREAST-Q 问卷调查,接受新型放射治疗的患者对胸部健康的满意度较低。有必要进行随机对照试验来进一步研究这些发现。此外,还需要进行长期随访以评估肿瘤结果。
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引用次数: 0
Observational cohort study on safety and efficacy of robotic thyroidectomy with super-meticulous capsular dissection versus open surgery for thyroid cancer: Postoperative dynamic risk assessment of radioactive iodine therapy. 甲状腺癌机器人甲状腺切除术与开刀手术安全性和有效性的观察性队列研究:放射性碘治疗的术后动态风险评估。
IF 12.5 2区 医学 Q1 SURGERY Pub Date : 2024-09-12 DOI: 10.1097/JS9.0000000000002071
Xiangquan Qin, Yufan Zhang, Jia Luo, Lingjuan Zeng, Xia Liu, Ting Zhang, Lin Ren, Linjun Fan, Dingde Huang

Objective: To assess the efficacy and safety of robotic thyroidectomy (RT) with super-meticulous capsular dissection (SMCD) versus open thyroidectomy (OT) we used a dynamic risk assessment system incorporating 131I-WBS along with radioactive iodine (RAI) efficacy evaluation.

Background: Currently, the therapeutic efficacy of robotic surgery remains controversial. The 131I whole-body scan (131I-WBS) dynamic risk assessment system can detect small residual thyroid tissues and lesions, which may be used as indicators for the surgical efficacy of RT or OT thyroidectomy in differentiated thyroid cancer (DTC).

Methods: This retrospective cohort study included 2,349 patients who underwent total thyroidectomy followed by RAI therapy in our department between August 2017 and June 2023. Propensity score matching was performed at a ratio of 1:3 based on surgical type and mean follow-up duration to minimize selection bias after excluding those lost to follow-up. The primary outcome was surgical completeness, assessed using a dynamic risk system incorporating 131I-WBS along with RAI efficacy evaluation.

Results: There was no significant difference in the number of metastatic lymph nodes removed between the two groups (P=0.45). The incidence rate of parathyroid gland transplantation was 395 (68.7%) in the OT group and 8 (3.8%) in the RT group (P<0.001). There were no differences in the thyroidectomy completeness based on the 3-hour iodine uptake rate and 99mTcO4- thyroid imaging between the two groups. The dynamic risk assessment with and without 131I-WBS showed significant differences (P<0.001). The postoperative and post-RAI dynamic risk scores, evaluated at the time of RAI and 6 months after RAI, did not differ significantly between the two groups (P>0.05). The rates of transient and permanent hypoparathyroidism were higher in the OT group than in the RT group (P<0.05). The local recurrence rates showed no significant difference between the groups.

Conclusions: This study demonstrates that RT with SMCD can achieve outcomes equivalent to those of traditional open surgery when integrating the 131I-WBS dynamic evaluation system and the therapeutic effects of RAI. Additionally, robot surgery demonstrated a notable advantage in protecting parathyroid function.

目的为了评估机器人甲状腺切除术(RT)与超微创囊膜剥离术(SMCD)和开放式甲状腺切除术(OT)的疗效和安全性,我们使用了一个动态风险评估系统,该系统结合了131I-WBS和放射性碘(RAI)疗效评估:背景:目前,机器人手术的疗效仍存在争议。131I全身扫描(131I-WBS)动态风险评估系统能检测出甲状腺小残留组织和病灶,可作为分化型甲状腺癌(DTC)RT或OT甲状腺切除术的手术疗效指标:这项回顾性队列研究纳入了2017年8月至2023年6月期间在我科接受甲状腺全切除术后接受RAI治疗的2349例患者。根据手术类型和平均随访时间,以1:3的比例进行倾向评分匹配,以在排除失去随访的患者后尽量减少选择偏倚。主要结果是手术的完整性,使用动态风险系统结合 131I-WBS 和 RAI 疗效评估进行评估:结果:两组患者切除的转移淋巴结数量无明显差异(P=0.45)。OT组甲状旁腺移植发生率为395例(68.7%),RT组为8例(3.8%)(P0.05)。OT组一过性和永久性甲状旁腺功能减退症的发生率高于RT组(PC结论:本研究表明,在结合131I-WBS动态评估系统和RAI治疗效果的情况下,使用SMCD的RT可获得与传统开放手术相当的疗效。此外,机器人手术在保护甲状旁腺功能方面具有显著优势。
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引用次数: 0
Effect of extracorporeal shock wave therapy on the microbial community in burn scars: retrospective case-control study. 体外冲击波疗法对烧伤疤痕微生物群落的影响:回顾性病例对照研究。
IF 12.5 2区 医学 Q1 SURGERY Pub Date : 2024-09-11 DOI: 10.1097/JS9.0000000000002083
Yeongyun Jung, Ryeong-Hui Kim, Eun Kyung Lee, Cheong Hoon Seo, So Young Joo, Jae-Ho Shin, Yoon Soo Cho

Background: The effectiveness of extracorporeal shock wave therapy (ESWT) has been demonstrated in various medical fields, including burn medicine. It promotes wound healing, improves blood flow, and modulates the inflammatory responses. The recovery speed and outcomes of skin diseases are influenced by the skin microbiome; however, studies examining the effects of specific treatments on the skin microbiome are lacking. This study investigated the impact of ESWT on the skin microbiome of burn patients, focusing on the microbial diversity and community structure within burn scars.

Materials and methods: In the retrospective case-control study, nineteen patients with burn scars were treated with ESWT, and changes in their skin microbiome were evaluated. ESWT was administered weekly for three months, and samples were collected from the ESWT-treated burn scars and untreated normal skin. Blood chemistry, and pain and itching scores were evaluated during sample collection. The collected samples were then subjected to 16S rRNA sequencing. Microbial community analysis was conducted using the QIIME2 and R packages.

Results: After ESWT, changes in alpha diversity indices were observed in burn scars. Faith phylogenetic diversity (P<0.05) and observed features (P<0.01) increased, whereas the evenness index decreased (P<0.01); no marked changes were noted in untreated skin. Beta diversity analysis showed stable microbial community structures in both the treated and untreated areas. A considerable increase in Micrococcus and Staphylococcus abundance was observed. Network analysis revealed a more open microbial network structure after ESWT, indicating adaptive changes in the microbial community.

Conclusion: ESWT enhances microbial diversity and modifies microbial community structure in burn scars, promoting a more balanced and functionally supportive microbiome. ESWT aids in scar remodeling and positively influences skin microbiome dynamics, contributing to improved skin health and recovery.

背景:体外冲击波疗法(ESWT)的有效性已在包括烧伤医学在内的多个医学领域得到证实。它能促进伤口愈合、改善血流并调节炎症反应。皮肤疾病的恢复速度和治疗效果受皮肤微生物群的影响;然而,目前还缺乏有关特定疗法对皮肤微生物群影响的研究。本研究调查了 ESWT 对烧伤患者皮肤微生物组的影响,重点是烧伤疤痕内的微生物多样性和群落结构:在这项回顾性病例对照研究中,19 名烧伤疤痕患者接受了 ESWT 治疗,并对其皮肤微生物群的变化进行了评估。每周进行一次 ESWT,持续三个月,并从 ESWT 治疗过的烧伤疤痕和未治疗过的正常皮肤中采集样本。在样本采集过程中,对血液化学成分、疼痛和瘙痒评分进行了评估。然后对采集的样本进行 16S rRNA 测序。微生物群落分析使用 QIIME2 和 R 软件包进行:结果:ESWT 后,烧伤疤痕中的α多样性指数发生了变化。结果:ESWT 后,烧伤疤痕的阿尔法多样性指数发生了变化:ESWT 提高了烧伤疤痕中微生物的多样性并改变了微生物群落结构,促进了微生物群落的平衡和功能支持。ESWT 有助于疤痕重塑,并对皮肤微生物群动态产生积极影响,有助于改善皮肤健康和恢复。
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引用次数: 0
Using computed tomography to evaluate anatomic landmarks in taiwanese trauma patients for insertion of resuscitative endovascular balloon occlusion of the aorta: A retrospective cohort study. 使用计算机断层扫描评估台湾创伤患者的解剖标志,以便插入抢救性主动脉血管内球囊闭塞术:一项回顾性队列研究。
IF 12.5 2区 医学 Q1 SURGERY Pub Date : 2024-09-09 DOI: 10.1097/JS9.0000000000002079
Chih-Ying Chien, Yueh-Lin Lee, Mei-Jy Jeng, Chia-Jen Liu

Background: Hemorrhage, particularly from non-compressible torso hemorrhage (NCTH) in the abdominopelvic region, is a leading cause of preventable trauma deaths. Resuscitative endovascular balloon occlusion of the aorta (REBOA), designed for aortic occlusion, has emerged as a tool for temporary hemorrhage control in recent years. However, attaining optimal REBOA placement in diverse demographic groups, such as Asian populations, may pose challenges owing to unique anatomical and physiological differences.

Materials and methods: This retrospective study analyzed trauma patients who underwent torso computed tomography (CT) at tertiary hospitals in Taiwan from January 2014 to January 2017. The OsiriX software was used to measure the endovascular lengths in the CT images.

Results: Among the 223 patients, the median vascular lengths and body measurements were higher in males. The optimal fixed insertion length was identified as 47.5 cm for zone 1 with 99.43% accuracy and 25.5 cm with 82.1% accuracy for zone 3. The landmark-guided method showed 100% accuracy for zone 1 when using the mid-sternum and 94.6% for zone 3 with the umbilicus as the guide with the distance between the umbilicus, xiphoid process, and pubic ramus. External validation confirmed the accuracy of the landmark-guided method.

Conclusions: For zone 1 occlusions, a range of 44-48 cm insertion length cross-referenced with the mid-sternal landmark is recommended. For zone 3 occlusions, using the umbilicus as a guide with the distance between the umbilicus, xiphoid process, and pubic ramus provided the highest accuracy.

背景:大出血,尤其是腹盆腔非压缩性躯干出血(NCTH),是可预防的创伤死亡的主要原因。近年来,专为主动脉闭塞而设计的主动脉血管内球囊闭塞复苏术(REBOA)已成为一种临时控制出血的工具。然而,由于独特的解剖和生理差异,在亚洲等不同人口群体中实现最佳REBOA置入可能会带来挑战:这项回顾性研究分析了 2014 年 1 月至 2017 年 1 月期间在台湾三级医院接受躯干计算机断层扫描(CT)的创伤患者。使用 OsiriX 软件测量 CT 图像中的血管内长度:结果:在223名患者中,男性的血管长度和身体测量中位数更高。最佳固定插入长度在 1 区为 47.5 厘米,准确率为 99.43%,在 3 区为 25.5 厘米,准确率为 82.1%。地标引导法使用胸骨中段时,1 区的准确率为 100%,使用脐部作为引导,以脐部、剑突和耻骨横突之间的距离为 3 区的准确率为 94.6%。外部验证证实了地标引导法的准确性:结论:对于 1 区闭塞,建议以胸骨中线地标为参照,插入长度范围为 44-48 厘米。对于 3 区闭塞,以脐部为导向,脐部、剑突和耻骨横突之间的距离提供了最高的准确性。
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引用次数: 0
Clinical, sonographic and molecular changes in calcific tendinitis of the shoulder following extracorporeal shockwave therapy: a prospective case-control study. 体外冲击波疗法后肩部钙化性肌腱炎的临床、声像图和分子变化:一项前瞻性病例对照研究。
IF 12.5 2区 医学 Q1 SURGERY Pub Date : 2024-09-06 DOI: 10.1097/JS9.0000000000002078
Wen-Yi Chou, Kuan-Ting Wu, Po-Cheng Chen, Shun-Wun Jhan, Chia-Feng Wu, Jai-Hong Cheng

Background: Extracorporeal shockwave therapy (ESWT) is the primary treatment for calcific tendinitis of the shoulders, but what are the effects of clinical, sonographic, and molecular markers following ESWT in treating calcific tendinitis of the shoulder?

Methods: Twenty-eight patients were categorized into radiodense and radiolucent subgroups. In addition, clinical assessments included the visual analogue scale (VAS), Constant-Murley (CM) score, American Shoulder and Elbow Surgeon (ASES) score, sonographic evaluation, and serum enzyme-linked immunosorbent assay (ELISA). The participants completed a one-year follow-up. All data were collected before and after treatment.

Results: After one year of follow-up, all patients showed notable improvement in VAS, CM, and ASES scores, with no significant clinical variations among the subgroups. However, the radiolucent group showed significant complete resorption and size reduction at the final follow-up. Sonographic evaluation revealed improved tissue perfusion and reduced calcification from 3 to 12 months in all patients, including those in the radiolucent group, but complete resorption of calcific deposits did not occur. The percentage of tissue perfusion was improved at 1 and 3 months after ESWT. There were no significant differences in the levels of the molecular markers interleukin-1 beta (IL-1 β) or IL-33, but the level of insulin-like growth factor 1 (IGF-1) was notably increased at 1 and 3 months post-ESWT. The BMP7 level was increased at 3 months and was then decreased significantly at 6 and 12 months.

Conclusion: ESWT improved symptoms, reduced calcification, enhanced tissue perfusion, and promoted angiogenesis and BMP7 activity. In particular, it benefited radiolucent type patients with better calcification resorption. Partial resorption led to improvements in transparency, and a second ESWT session at 3 months was recommended for optimal results.

背景:体外冲击波疗法(ESWT)是治疗肩部钙化性肌腱炎的主要方法,但体外冲击波疗法治疗肩部钙化性肌腱炎后,临床、声像图和分子标记物的效果如何?将 28 名患者分为放射密度亚组和放射透明亚组。此外,临床评估还包括视觉模拟量表(VAS)、Constant-Murley(CM)评分、美国肩肘外科医生(ASES)评分、声学评估和血清酶联免疫吸附试验(ELISA)。参与者完成了为期一年的随访。所有数据均在治疗前后收集:随访一年后,所有患者的 VAS、CM 和 ASES 评分均有明显改善,各亚组之间无明显临床差异。然而,放射线透视组在最后随访时显示出明显的完全吸收和体积缩小。声学评估显示,从3个月到12个月,所有患者的组织灌注都有所改善,钙化也有所减少,包括放射线透视组患者,但钙化沉积物并未完全吸收。ESWT 治疗后 1 个月和 3 个月,组织灌注的百分比有所改善。分子标记物白细胞介素-1β(IL-1 β)或IL-33的水平无明显差异,但胰岛素样生长因子1(IGF-1)的水平在ESWT后1个月和3个月明显增加。BMP7水平在3个月时有所上升,但在6个月和12个月时又显著下降:ESWT可改善症状,减少钙化,增强组织灌注,促进血管生成和BMP7活性。结论:ESWT 可改善症状,减少钙化,增强组织灌注,促进血管生成和 BMP7 活性。部分钙化吸收可改善透明度,建议在 3 个月后进行第二次 ESWT 治疗,以达到最佳效果。
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引用次数: 0
Cardiovascular and all-cause mortality outcomes of adrenalectomy versus medical treatment in primary aldosteronism: an umbrella review. 肾上腺切除术与药物治疗对原发性醛固酮增多症的心血管和全因死亡率的影响:综述。
IF 12.5 2区 医学 Q1 SURGERY Pub Date : 2024-09-06 DOI: 10.1097/JS9.0000000000002048
Sandeep Samethadka Nayak, Ehsan Amini-Salehi, Farahnaz Joukar, Pubali Biswas, Sara Nobakht, Negin Letafatkar, Parham Porteghali, Erfan Mohammadi-Vajari, Fariborz Mansour-Ghanaei, Mona Javid, Arian Mirdamadi, Daniyal Ameen, Behrang Motamed, Soheil Hassanipour, Mohammad-Hossein Keivanlou

Background: Primary aldosteronism (PA) is now recognized as the most prevalent form of secondary hypertension globally, contributing significantly to cardiovascular morbidity and mortality. This umbrella review aims to systematically compare cardiovascular outcomes and all-cause mortality in PA patients undergoing adrenalectomy versus mineralocorticoid receptor antagonist (MRA) treatment, aiming to inform optimal management strategies.

Method: Following PRISMA guidelines, Supplemental Digital Content 1, http://links.lww.com/JS9/D386, Supplemental Digital Content 2, http://links.lww.com/JS9/D387, a comprehensive search strategy was employed across multiple databases. Meta-analyses focusing on cardiovascular outcomes or all-cause mortality, comparing adrenalectomy and MRAs treatment in PA patients, were included. Studies were independently screened and assessed for quality using AMSTAR 2, Supplemental Digital Content 3, http://links.lww.com/JS9/D388 and GRADE checklists.

Results: A total of 8 studies met the inclusion criteria. Adrenalectomy showed potential benefits over MRAs in reducing the risk of arrhythmias (OR=2.17; 95% CI: 1.25-3.76) and major adverse cardiovascular events (OR=1.81; 95% CI: 1.33-2.46). Patients treated with MRAs exhibited a higher risk of cardiovascular events (OR=1.23; 95% CI: 1.05-1.44), hypertension (OR=3.22; 95% CI: 1.15-8.97), and all-cause mortality (OR=3.03; 95% CI: 1.36-6.70) compared to adrenalectomy.

Conclusion: Adrenalectomy appears to offer favorable outcomes compared to MRAs treatment in PA patients, particularly in reducing the risk of major adverse cardiovascular events and all-cause mortality. These findings suggest the importance of considering surgical intervention as a primary treatment modality for PA.

背景:原发性醛固酮增多症(PA)目前被认为是全球最普遍的继发性高血压,对心血管疾病的发病率和死亡率有重大影响。本综述旨在系统比较接受肾上腺切除术与矿皮质激素受体拮抗剂(MRA)治疗的 PA 患者的心血管预后和全因死亡率,旨在为最佳管理策略提供参考:按照 PRISMA 指南(补充数字内容 1,http://links.lww.com/JS9/D386)和补充数字内容 2(http://links.lww.com/JS9/D387),在多个数据库中采用了全面的检索策略。纳入了以心血管预后或全因死亡率为重点、比较 PA 患者肾上腺切除术和 MRAs 治疗的 Meta 分析。采用 AMSTAR 2、Supplemental Digital Content 3、http://links.lww.com/JS9/D388 和 GRADE 检查表对研究进行独立筛选和质量评估:结果:共有 8 项研究符合纳入标准。肾上腺切除术在降低心律失常风险(OR=2.17;95% CI:1.25-3.76)和主要不良心血管事件(OR=1.81;95% CI:1.33-2.46)方面比 MRAs 有潜在优势。与肾上腺切除术相比,接受MRA治疗的患者发生心血管事件(OR=1.23;95% CI:1.05-1.44)、高血压(OR=3.22;95% CI:1.15-8.97)和全因死亡率(OR=3.03;95% CI:1.36-6.70)的风险更高:结论:与 MRAs 治疗相比,肾上腺切除术似乎能为 PA 患者带来更好的治疗效果,尤其是在降低主要不良心血管事件和全因死亡率风险方面。这些研究结果表明,将外科干预作为 PA 的主要治疗方式具有重要意义。
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引用次数: 0
Utilization of recurrent laryngeal nerve monitoring during thyroid surgery in china: a point prevalence survey (2015-2023). 中国甲状腺手术中喉返神经监测的使用情况:点流行率调查(2015-2023年)。
IF 12.5 2区 医学 Q1 SURGERY Pub Date : 2024-09-06 DOI: 10.1097/JS9.0000000000002084
Yishen Zhao, Peiyao Wang, Gianlorenzo Dionigi, Jiedong Kou, Changlin Li, Fang Li, Tie Wang, Wen Tian, Kewei Jiang, Ping Wang, Hao Zhang, Hui Sun

Background: The survey aimed to elucidate the complete range of national practices, including all technical and non-technical aspects, as well as surgical stratification and maturation, of the use of intraoperative neuromonitoring (IONM) during thyroid surgery in China.

Materials and methods: Six national questionnaires, developed by the Chinese Neural Monitoring Study Group (CNMSG) between 2015 and 2023, were used to collect and analyze data regarding the clinical application, education, and scientific research related to IONM in Chinese medical institutions.

Results: Among the surveyed hospitals, 45% reported an average annual surgical volume exceeding 3,000 cases, with 82.5% performing more than 80% of the surgeries for malignant thyroid tumors. Additionally, 97.5% of the hospitals reported a<3% incidence of postoperative hoarseness with IONM. Statistical analysis from 2011 to 2015 found that the incidence of postoperative hoarseness decreased by 30% in 2013 compared with 2011, when the technology was introduced. Preoperative and postoperative laryngoscopies were routinely performed by 82.5% and 15% of the hospitals, respectively. For 65% of the hospitals, the publication of the Chinese edition of neuromonitoring guidelines in 2013 prompted the utilization of IONM technology. An average annual number of IONM applications exceeding 500 cases (18.5% the average volume) was reported by 80% of the hospitals, while 62.5% reported a cumulative number of applications greater than 5,000 cases (47.1% the average cumulative volume). Regarding technical parameters, 75% of the hospitals reported an intraoperative V1 amplitude of >500 µV, and 70% reported an intraoperative loss of signal (LOS) rate of<3%. 92.5% of the surveyed hospitals believed that IONM could help identify dissociated nerves, and 95% of the surveyed hospitals believed that IONM could reduce nerve damage. However, 72.5% of the respondents thought that cost was the main limitation. Furthermore, 67.5% of the hospitals reported that half of their thyroid surgical team members were trained in IONM, with 17.5% reporting that all team members were trained. Areas for reinforced training included IONM research methods and directions (72.5%), and analysis and treatment of abnormal EMG signals (72.5%). Research projects related to IONM were conducted by 42.5% of the hospitals, while 52.5% had published papers on neuromonitoring.

Conclusions: IONM was independently and incrementally associated with the annual surgical volume. This survey emphasized the importance of national collaboration and/or a registry for the uptake, consolidation, and development of CNMSG consensus.

背景:该调查旨在阐明中国甲状腺手术中使用术中神经监测(IONM)的全部国家实践,包括所有技术和非技术方面,以及手术分层和成熟度:中国神经监测研究组(CNMSG)在2015年至2023年期间编制了6份全国性调查问卷,用于收集和分析中国医疗机构与术中神经监测相关的临床应用、教育和科研等方面的数据:在接受调查的医院中,45%的医院年均手术量超过3000例,82.5%的医院80%以上的手术都是针对甲状腺恶性肿瘤。此外,97.5%的医院报告的术中信号丢失率(LOS)为500 µV,70%的医院报告的术中信号丢失率(LOS)为结论:IONM与年手术量呈独立递增关系。这项调查强调了全国性合作和/或登记对于接受、巩固和发展 CNMSG 共识的重要性。
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International journal of surgery
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