Pub Date : 2024-08-02DOI: 10.23736/S2784-8671.24.07972-6
Alessia Paganelli, Elena Ficarelli, Alberico Motolese
{"title":"Epstein-Barr virus-related polymorphic eruption in a pediatric patient.","authors":"Alessia Paganelli, Elena Ficarelli, Alberico Motolese","doi":"10.23736/S2784-8671.24.07972-6","DOIUrl":"https://doi.org/10.23736/S2784-8671.24.07972-6","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141874811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-02DOI: 10.23736/S2784-8671.24.07792-2
Didem Kazan, Dilek Bayramgürler, Hatice E Şanli, Nahide Onsun, Serkan Yazici, Esra Adişen, Bahar S Dikicier, Burhan Engin, Ayşe Öktem, Günseli Öztürk, Ayda Acar, Aslı A Çerman, Selda P Kartal, Dilek S Gençosmanoğlu, Mehmet Melikoğlu, Aslı Bilgiç
Background: Mycosis fungoides (MF) is the most common cutaneous lymphoma with a chronic disease course. MF patients may also suffer from systemic comorbidities such as cardiovascular and metabolic diseases.
Methods: In this study, we aimed to evaluate the demographic and clinical features of MF patients registered in the MF-TR registry system and to examine the relationship of these features with systemic comorbidities. We collected the data from the medical files of the patients via the MF-TR registry system.
Results: Our study included 728 patients with MF, of which 396 (54.40%) were male and 332 (45.60%) were female. The most common additional systemic disease observed was hypertension, affecting 124 (17.03%) patients. This was followed by multinodular goiter in 66 (9.06%) patients, and diabetes mellitus type 2 in 61 (8.37%) patients. Twenty-two (3.02%) patients had a history of another secondary malignancy, with lung cancer being the most common type, affecting 5 (0.68%) patients. Female gender and high BMI were statistically higher in MF patients with asthma (P=0.019 and P=0.031, respectively). In patients with hypertension and hypercholesterolemia, the duration of diagnosis was significantly longer (P=0.013 and P=0.047, respectively).
Conclusions: Dermatologists should be aware of these accompanying comorbidities in patients with MF. Multidisciplinary evaluation should be performed in the follow-up, if necessary.
{"title":"Evaluation of demographic and clinical characteristics of 728 patients with mycosis fungoides and their relationship with systemic comorbidities: multicenter, registry-based (MF-TR) study from Türkiye.","authors":"Didem Kazan, Dilek Bayramgürler, Hatice E Şanli, Nahide Onsun, Serkan Yazici, Esra Adişen, Bahar S Dikicier, Burhan Engin, Ayşe Öktem, Günseli Öztürk, Ayda Acar, Aslı A Çerman, Selda P Kartal, Dilek S Gençosmanoğlu, Mehmet Melikoğlu, Aslı Bilgiç","doi":"10.23736/S2784-8671.24.07792-2","DOIUrl":"https://doi.org/10.23736/S2784-8671.24.07792-2","url":null,"abstract":"<p><strong>Background: </strong>Mycosis fungoides (MF) is the most common cutaneous lymphoma with a chronic disease course. MF patients may also suffer from systemic comorbidities such as cardiovascular and metabolic diseases.</p><p><strong>Methods: </strong>In this study, we aimed to evaluate the demographic and clinical features of MF patients registered in the MF-TR registry system and to examine the relationship of these features with systemic comorbidities. We collected the data from the medical files of the patients via the MF-TR registry system.</p><p><strong>Results: </strong>Our study included 728 patients with MF, of which 396 (54.40%) were male and 332 (45.60%) were female. The most common additional systemic disease observed was hypertension, affecting 124 (17.03%) patients. This was followed by multinodular goiter in 66 (9.06%) patients, and diabetes mellitus type 2 in 61 (8.37%) patients. Twenty-two (3.02%) patients had a history of another secondary malignancy, with lung cancer being the most common type, affecting 5 (0.68%) patients. Female gender and high BMI were statistically higher in MF patients with asthma (P=0.019 and P=0.031, respectively). In patients with hypertension and hypercholesterolemia, the duration of diagnosis was significantly longer (P=0.013 and P=0.047, respectively).</p><p><strong>Conclusions: </strong>Dermatologists should be aware of these accompanying comorbidities in patients with MF. Multidisciplinary evaluation should be performed in the follow-up, if necessary.</p>","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141874812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-02DOI: 10.23736/S2784-8671.24.07980-5
Vitali Bagirov, Erhard Bierhoff, Manfred Uerlich, Jörg Wenzel, Robert Fuhrmans, Dieter Metze, Thomas Dirschka, Lutz Schmitz
Background: Excision and histological examination of cutaneous neoplasms are very common diagnostic and therapeutic procedures in dermatological practice. There are often discrepancies between tissue seize in vivo and after histopathological work-up. This may raise questions according to tumor sizes or safety margins.
Methods: To investigate the effect of excision and histological processing on the properties of cutaneous neoplasms in real-life 401 specimens in 324 patients were prospectively investigated. Delineated excision margins of cutaneous neoplasms were documented prior to (T0) and post excision (T1). Length, width and thickness were measured after ≥48 h of formalin fixation (T2) and after sectioning (T3) on final histological slices. Accompanying parameters such as patient age, gender, anatomical site, and tumor entity were evaluated.
Results: All post-processed tissue exhibited a significant (P<0.001) median (interquartile range) reduction in length, width and thickness of 21.0% (9.5-30.0), 30.7% (20.0-40.0), and 28.0% (4.8-46.7), respectively, irrespective of site, patient age or tumor entity. Maximum median (IQR) reduction for the length and the width was observed right after excision (17.0% [4.3-25.0] and 14.0% [11.1-28.6] reduction). No significant median (IQR) tissue changes between T1 and T2 were observed (length: 4.8% (-4.3-13.3); width: 0% (-17.6-11.1); thickness 0% (-32.0-20.0). Subgroup analyses showed significantly greater tissue shrinkage in younger patients and for tissue sample sites (trunk or lower extremities).
Conclusions: Most relevant shrinkage of cutaneous samples occurs right after excision. Age- and site-depended tissue contractility can influence these effects. Formalin fixation does not affect tissue shrinkage. Smaller tissue sizes on histopathological reports are to be expected.
{"title":"Cutaneous tissue samples show significant shrinkage during histopathological work-up: a real-world study.","authors":"Vitali Bagirov, Erhard Bierhoff, Manfred Uerlich, Jörg Wenzel, Robert Fuhrmans, Dieter Metze, Thomas Dirschka, Lutz Schmitz","doi":"10.23736/S2784-8671.24.07980-5","DOIUrl":"https://doi.org/10.23736/S2784-8671.24.07980-5","url":null,"abstract":"<p><strong>Background: </strong>Excision and histological examination of cutaneous neoplasms are very common diagnostic and therapeutic procedures in dermatological practice. There are often discrepancies between tissue seize in vivo and after histopathological work-up. This may raise questions according to tumor sizes or safety margins.</p><p><strong>Methods: </strong>To investigate the effect of excision and histological processing on the properties of cutaneous neoplasms in real-life 401 specimens in 324 patients were prospectively investigated. Delineated excision margins of cutaneous neoplasms were documented prior to (T0) and post excision (T1). Length, width and thickness were measured after ≥48 h of formalin fixation (T2) and after sectioning (T3) on final histological slices. Accompanying parameters such as patient age, gender, anatomical site, and tumor entity were evaluated.</p><p><strong>Results: </strong>All post-processed tissue exhibited a significant (P<0.001) median (interquartile range) reduction in length, width and thickness of 21.0% (9.5-30.0), 30.7% (20.0-40.0), and 28.0% (4.8-46.7), respectively, irrespective of site, patient age or tumor entity. Maximum median (IQR) reduction for the length and the width was observed right after excision (17.0% [4.3-25.0] and 14.0% [11.1-28.6] reduction). No significant median (IQR) tissue changes between T1 and T2 were observed (length: 4.8% (-4.3-13.3); width: 0% (-17.6-11.1); thickness 0% (-32.0-20.0). Subgroup analyses showed significantly greater tissue shrinkage in younger patients and for tissue sample sites (trunk or lower extremities).</p><p><strong>Conclusions: </strong>Most relevant shrinkage of cutaneous samples occurs right after excision. Age- and site-depended tissue contractility can influence these effects. Formalin fixation does not affect tissue shrinkage. Smaller tissue sizes on histopathological reports are to be expected.</p>","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141874809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-01Epub Date: 2024-05-23DOI: 10.23736/S2784-8671.24.07726-0
Alessandro Pileri, Giorgio Gentile, Fulvio Colombo, Silvia Robuffo, Corrado Zengarini, Bianca M Piraccini, Lorenzo Maltoni
{"title":"Penile ulceration due to local kanamycin ointment self-injection for aesthetic purposes.","authors":"Alessandro Pileri, Giorgio Gentile, Fulvio Colombo, Silvia Robuffo, Corrado Zengarini, Bianca M Piraccini, Lorenzo Maltoni","doi":"10.23736/S2784-8671.24.07726-0","DOIUrl":"10.23736/S2784-8671.24.07726-0","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141081587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-01Epub Date: 2024-05-27DOI: 10.23736/S2784-8671.24.07749-1
Gilberto Pires DA Rosa, Maria J Cruz, Filomena Azevedo, Alberto Mota
{"title":"Concurrent therapy with dupilumab and infliximab for atopic dermatitis and Crohn's disease.","authors":"Gilberto Pires DA Rosa, Maria J Cruz, Filomena Azevedo, Alberto Mota","doi":"10.23736/S2784-8671.24.07749-1","DOIUrl":"10.23736/S2784-8671.24.07749-1","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141157986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-01Epub Date: 2024-06-03DOI: 10.23736/S2784-8671.24.07867-8
Stefano Astorino, Donato DI Nunno, Azzurra Monfrecola, Angela Ferrari, Angelo Saponaro, Carlo Catalano, Giorgio Troiani, Alessandro Laghi
{"title":"Primary cutaneous cribriform apocrine carcinoma: a dermatoscopic pitfall.","authors":"Stefano Astorino, Donato DI Nunno, Azzurra Monfrecola, Angela Ferrari, Angelo Saponaro, Carlo Catalano, Giorgio Troiani, Alessandro Laghi","doi":"10.23736/S2784-8671.24.07867-8","DOIUrl":"10.23736/S2784-8671.24.07867-8","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141199841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-01Epub Date: 2024-06-05DOI: 10.23736/S2784-8671.24.07953-2
Isotta Giunipero DI Corteranzo, Gabriele Roccuzzo, Orsola Crespi, Giovanni Cavaliere, Paolo Fava, Simone Ribero, Pietro Quaglino
{"title":"Mogamulizumab associated crusted scabies: a rare diagnostic confounder.","authors":"Isotta Giunipero DI Corteranzo, Gabriele Roccuzzo, Orsola Crespi, Giovanni Cavaliere, Paolo Fava, Simone Ribero, Pietro Quaglino","doi":"10.23736/S2784-8671.24.07953-2","DOIUrl":"10.23736/S2784-8671.24.07953-2","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141261925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-01Epub Date: 2024-06-05DOI: 10.23736/S2784-8671.24.07795-8
Alessandro Fraghì, Martina Perantoni, Iacopo Ghini, Davide Geat, Simone Soglia, Giulio E Mandelli, Francesco Tonon, Cesare Ariasi, Silvia Zanghì, Piergiacomo Calzavara-Pinton
{"title":"Pleomorphic dermal sarcoma and regression: a description of two cases with clinico-histological regression.","authors":"Alessandro Fraghì, Martina Perantoni, Iacopo Ghini, Davide Geat, Simone Soglia, Giulio E Mandelli, Francesco Tonon, Cesare Ariasi, Silvia Zanghì, Piergiacomo Calzavara-Pinton","doi":"10.23736/S2784-8671.24.07795-8","DOIUrl":"10.23736/S2784-8671.24.07795-8","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141261927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-01Epub Date: 2024-05-02DOI: 10.23736/S2784-8671.24.07738-7
Paolo Romita, Domenico Bonamonte, Aurora DE Marco, Serena C Mercurio, Gianluca Calianno, Andrea Chiricozzi, Caterina Foti
{"title":"A new light on secukinumab in pediatric psoriasis.","authors":"Paolo Romita, Domenico Bonamonte, Aurora DE Marco, Serena C Mercurio, Gianluca Calianno, Andrea Chiricozzi, Caterina Foti","doi":"10.23736/S2784-8671.24.07738-7","DOIUrl":"10.23736/S2784-8671.24.07738-7","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140856283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-01Epub Date: 2024-05-23DOI: 10.23736/S2784-8671.24.07895-2
Giulia Ciccarese, Francesco Drago, Astrid Herzum, Laura Atzori, Annunziata Dattola, Marco Galluzzo, Carlo Maronese, Annalisa Patrizi, Bianca M Piraccini, Sebastiano Recalcati, Maria C Fargnoli, Angelo V Marzano, Manuela Papini
Herpes zoster (HZ) is a condition caused by the reactivation of varicella-zoster virus (VZV), the virus responsible for chickepox, which is the clinical manifestation of the primary infection. Congenital or acquired immune system deficiencies, as well as the physiological decline in immune response occurring in the elderly, known as immune senescence, can allow VZV reactivation and, consequently, HZ. One out of 3 people develops HZ during their lifetime. Moreover, thirty percent of the affected subjects develop post-herpetic neuralgia, the most frequent complication after HZ skin rash. Patients with dermatological conditions characterized by alteration of the immune system, such as systemic lupus erythematosus, psoriasis, atopic dermatitis, bullous diseases, and cutaneous lymphomas, are at higher risk of developing HZ and post-herpetic neuralgia, even when their disease is in remission. In the present work, we described the currently available vaccinations against HZ and provided recommendations for the vaccination against HZ in patients with dermatological diseases.
{"title":"Anti-Herpes zoster vaccination in patients with dermatologic diseases: a position statement from the Italian SIDeMaST group of sexually transmitted, infectious and tropical diseases.","authors":"Giulia Ciccarese, Francesco Drago, Astrid Herzum, Laura Atzori, Annunziata Dattola, Marco Galluzzo, Carlo Maronese, Annalisa Patrizi, Bianca M Piraccini, Sebastiano Recalcati, Maria C Fargnoli, Angelo V Marzano, Manuela Papini","doi":"10.23736/S2784-8671.24.07895-2","DOIUrl":"10.23736/S2784-8671.24.07895-2","url":null,"abstract":"<p><p>Herpes zoster (HZ) is a condition caused by the reactivation of varicella-zoster virus (VZV), the virus responsible for chickepox, which is the clinical manifestation of the primary infection. Congenital or acquired immune system deficiencies, as well as the physiological decline in immune response occurring in the elderly, known as immune senescence, can allow VZV reactivation and, consequently, HZ. One out of 3 people develops HZ during their lifetime. Moreover, thirty percent of the affected subjects develop post-herpetic neuralgia, the most frequent complication after HZ skin rash. Patients with dermatological conditions characterized by alteration of the immune system, such as systemic lupus erythematosus, psoriasis, atopic dermatitis, bullous diseases, and cutaneous lymphomas, are at higher risk of developing HZ and post-herpetic neuralgia, even when their disease is in remission. In the present work, we described the currently available vaccinations against HZ and provided recommendations for the vaccination against HZ in patients with dermatological diseases.</p>","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141081601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}