Pub Date : 2024-08-01Epub Date: 2024-05-02DOI: 10.23736/S2784-8671.24.07801-0
Giulia Calabrese, Vittorio Tancredi, Alina DE Rosa, Caterina M Giorgio, Gaetano Licata
{"title":"A case of cutaneous nodular amyloidosis in an adolescent patient.","authors":"Giulia Calabrese, Vittorio Tancredi, Alina DE Rosa, Caterina M Giorgio, Gaetano Licata","doi":"10.23736/S2784-8671.24.07801-0","DOIUrl":"10.23736/S2784-8671.24.07801-0","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140860812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-01Epub Date: 2024-05-27DOI: 10.23736/S2784-8671.24.07764-8
Giorgio Raposio, Alessandro Gualdi, Ilaria Baldelli, Edoardo Raposio
Introduction: Surgical therapy of basal cell carcinomas (BCC) is based on complete excision of the neoplasm and its immediate suitable reconstruction. The aim of this work was to evaluate the possibility of creating a reconstructive algorithm in cases of scalp BCC, depending on the amplitude of the tumor.
Evidence acquisition: A literature search was carried out using the databases of PubMed, Scopus and Cochrane.
Evidence synthesis: Based on the experiences reported in the literature, it was possible to structure a decision-making algorithm that summarizes the various steps involved in the choice of the most suitable reconstructive surgical therapy.
Conclusions: The algorithm described we hope will be of reference or help to less experienced reconstructive plastic surgeons.
{"title":"Basal cell carcinoma of the scalp: surgical approach and reconstructive options.","authors":"Giorgio Raposio, Alessandro Gualdi, Ilaria Baldelli, Edoardo Raposio","doi":"10.23736/S2784-8671.24.07764-8","DOIUrl":"10.23736/S2784-8671.24.07764-8","url":null,"abstract":"<p><strong>Introduction: </strong>Surgical therapy of basal cell carcinomas (BCC) is based on complete excision of the neoplasm and its immediate suitable reconstruction. The aim of this work was to evaluate the possibility of creating a reconstructive algorithm in cases of scalp BCC, depending on the amplitude of the tumor.</p><p><strong>Evidence acquisition: </strong>A literature search was carried out using the databases of PubMed, Scopus and Cochrane.</p><p><strong>Evidence synthesis: </strong>Based on the experiences reported in the literature, it was possible to structure a decision-making algorithm that summarizes the various steps involved in the choice of the most suitable reconstructive surgical therapy.</p><p><strong>Conclusions: </strong>The algorithm described we hope will be of reference or help to less experienced reconstructive plastic surgeons.</p>","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141157946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-01Epub Date: 2024-05-23DOI: 10.23736/S2784-8671.24.07894-0
Randa Bushwereb, Gautam Srivastava
Introduction: Alopecia areata poses a significant challenge due to its chronic autoimmune nature, leading to psychosocial impacts. Recent strides in understanding the disease have spotlighted Janus kinase (JAK) inhibitors as potential therapies. This comprehensive review aims to assess Baricitinib's efficacy and safety in treating scalp, eyebrow, and eyelash alopecia areata, and compare the effectiveness of Ritlecitinib and Brepocitinib.
Evidence acquisition: Conducting a thorough electronic literature search, we focused on clinical studies of JAK inhibitors for moderate to severe alopecia areata from 2015 onward. Key databases, including MEDLINE, PubMed, Cochrane Library, EMBASE, Google Scholar, and Medscape, were utilized. Primary outcomes included changes in the Severity of Alopecia Tool (SALT) score, with safety data evaluating adverse events and serious adverse events. The risk of bias was assessed using the Cochrane Risk of Bias Tool.
Evidence synthesis: Among the twelve studies identified, Baricitinib demonstrated superior efficacy over placebo at 24 weeks, with both 2mg and 4mg dosages significantly reducing SALT scores. Comparative efficacy at 24 weeks for Baricitinib, Brepocitinib, and Ritlecitinib showed similar effectiveness compared to placebo, with a marginal superiority observed for Baricitinib 4mg. All JAK inhibitors were well-tolerated, with reported adverse events primarily being mild and manageable.
Conclusions: Collectively, the reviewed studies affirm JAK inhibitors, particularly Baricitinib, as promising treatments for moderate to severe alopecia areata. These inhibitors exhibit superior efficacy, as indicated by notable reductions in SALT scores, and are well-tolerated, with predominantly mild and manageable adverse events.
{"title":"Exploring Janus kinase inhibitors for alopecia areata: a comprehensive review.","authors":"Randa Bushwereb, Gautam Srivastava","doi":"10.23736/S2784-8671.24.07894-0","DOIUrl":"10.23736/S2784-8671.24.07894-0","url":null,"abstract":"<p><strong>Introduction: </strong>Alopecia areata poses a significant challenge due to its chronic autoimmune nature, leading to psychosocial impacts. Recent strides in understanding the disease have spotlighted Janus kinase (JAK) inhibitors as potential therapies. This comprehensive review aims to assess Baricitinib's efficacy and safety in treating scalp, eyebrow, and eyelash alopecia areata, and compare the effectiveness of Ritlecitinib and Brepocitinib.</p><p><strong>Evidence acquisition: </strong>Conducting a thorough electronic literature search, we focused on clinical studies of JAK inhibitors for moderate to severe alopecia areata from 2015 onward. Key databases, including MEDLINE, PubMed, Cochrane Library, EMBASE, Google Scholar, and Medscape, were utilized. Primary outcomes included changes in the Severity of Alopecia Tool (SALT) score, with safety data evaluating adverse events and serious adverse events. The risk of bias was assessed using the Cochrane Risk of Bias Tool.</p><p><strong>Evidence synthesis: </strong>Among the twelve studies identified, Baricitinib demonstrated superior efficacy over placebo at 24 weeks, with both 2mg and 4mg dosages significantly reducing SALT scores. Comparative efficacy at 24 weeks for Baricitinib, Brepocitinib, and Ritlecitinib showed similar effectiveness compared to placebo, with a marginal superiority observed for Baricitinib 4mg. All JAK inhibitors were well-tolerated, with reported adverse events primarily being mild and manageable.</p><p><strong>Conclusions: </strong>Collectively, the reviewed studies affirm JAK inhibitors, particularly Baricitinib, as promising treatments for moderate to severe alopecia areata. These inhibitors exhibit superior efficacy, as indicated by notable reductions in SALT scores, and are well-tolerated, with predominantly mild and manageable adverse events.</p>","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141081602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-01Epub Date: 2024-05-23DOI: 10.23736/S2784-8671.24.07892-7
Alessandra Gelmetti, Alessandro Pileri, Fabio Caramelli, Marco A Chessa, Cosimo Misciali, Bianca M Piraccini, Iria Neri
{"title":"Pediatric Stevens-Johnson syndrome/toxic epidermal necrolysis overlap: time to draw up treatment guidelines?","authors":"Alessandra Gelmetti, Alessandro Pileri, Fabio Caramelli, Marco A Chessa, Cosimo Misciali, Bianca M Piraccini, Iria Neri","doi":"10.23736/S2784-8671.24.07892-7","DOIUrl":"10.23736/S2784-8671.24.07892-7","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141081603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-01Epub Date: 2024-06-17DOI: 10.23736/S2784-8671.24.07719-3
Federica Li Pomi, Laura Macca, Mario Vaccaro, Maria Lentini, Francesco Borgia
{"title":"Eruptive blue nevi of the scalp mimicking melanoma metastases.","authors":"Federica Li Pomi, Laura Macca, Mario Vaccaro, Maria Lentini, Francesco Borgia","doi":"10.23736/S2784-8671.24.07719-3","DOIUrl":"10.23736/S2784-8671.24.07719-3","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141330956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-01Epub Date: 2024-06-03DOI: 10.23736/S2784-8671.24.07921-0
Annunziata Dattola, Nicoletta Bernardini, Jasmine Anedda, Laura Atzori, Claudio Bonifati, Pier L Bruni, Dario Graceffa, Domenico Giordano, Elisa Molinelli, Gaia Moretta, Cristina Mugheddu, Annamaria Offidani, Gianluca Pagnanelli, Sabatino Pallotta, Manuela Papini, Severino Persechino, Antonio G Richetta, Ersilia Tolino, Giovanni Pellacani, Concetta Potenza
{"title":"The role of guselkumab in psoriatic artrithis and disease progression in patients with confirmed diagnosis of enthesitis.","authors":"Annunziata Dattola, Nicoletta Bernardini, Jasmine Anedda, Laura Atzori, Claudio Bonifati, Pier L Bruni, Dario Graceffa, Domenico Giordano, Elisa Molinelli, Gaia Moretta, Cristina Mugheddu, Annamaria Offidani, Gianluca Pagnanelli, Sabatino Pallotta, Manuela Papini, Severino Persechino, Antonio G Richetta, Ersilia Tolino, Giovanni Pellacani, Concetta Potenza","doi":"10.23736/S2784-8671.24.07921-0","DOIUrl":"10.23736/S2784-8671.24.07921-0","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141199842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-01Epub Date: 2024-05-23DOI: 10.23736/S2784-8671.24.07925-8
Giuseppe Russo, Shireen Dumont, Emmanuel Laffitte
{"title":"Successful therapy of refractory cutaneous morphea with tofacitinib.","authors":"Giuseppe Russo, Shireen Dumont, Emmanuel Laffitte","doi":"10.23736/S2784-8671.24.07925-8","DOIUrl":"10.23736/S2784-8671.24.07925-8","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141081590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-01Epub Date: 2024-06-03DOI: 10.23736/S2784-8671.24.07812-5
Francesca Falcinelli, Arianna Lamberti, Elisa Cinotti, Pietro Rubegni, Laura Calabrese
{"title":"Diffuse purpuric pityriasis versicolor: a peculiar presentation.","authors":"Francesca Falcinelli, Arianna Lamberti, Elisa Cinotti, Pietro Rubegni, Laura Calabrese","doi":"10.23736/S2784-8671.24.07812-5","DOIUrl":"10.23736/S2784-8671.24.07812-5","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141199839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-01Epub Date: 2024-05-02DOI: 10.23736/S2784-8671.24.07776-4
Vincenzo Greco, Maria C Annunziata, Massimiliano Scalvenzi, Luca Costanzo, Giuseppe Lauletta, Antonio Portarapillo
{"title":"Therapeutic management of infantile digital fibromatosis.","authors":"Vincenzo Greco, Maria C Annunziata, Massimiliano Scalvenzi, Luca Costanzo, Giuseppe Lauletta, Antonio Portarapillo","doi":"10.23736/S2784-8671.24.07776-4","DOIUrl":"10.23736/S2784-8671.24.07776-4","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140852794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-23DOI: 10.23736/S2784-8671.24.07879-4
Elena Zappia, Nicole Macagno, Pietro Quaglino, Gabriele Roccuzzo, Simone Ribero
Introduction: Hand eczema (HE) is a prevalent inflammatory skin condition, impacting 15-20% of individuals, with a notable incidence rate of approximately 7.3 cases per 1000 person/years. This condition exhibits significant gender-based variability, with a higher prevalence in females. The clinical presentation of HE is characterized by pruritic erythematous, edematous, weeping plaques, vesicles, and/or bullae, showcasing considerable heterogeneity.
Evidence acquisition: A literature search was conducted across multiple databases, including Medline, Pubmed, Scopus, and the Cochrane Library. The search was conducted using the following key words and medical subject heading (MeSH) terms: "hand," "eczema," "dermatitis," "dermoscopy," and "histology," employing the Boolean term "AND" to combine the research terms for optimal search precision. PRISMA algorithm has been used for article screening. The search scope included manuscripts published up to October 1, 2023.
Evidence synthesis: Up to 50% of HE cases are associated with atopic dermatitis, emphasizing the complex interplay between various dermatological conditions. Common subtypes of HE include irritant contact dermatitis (ICD), allergic contact dermatitis (ACD), atopic hand eczema (AHE), and protein contact dermatitis/contact urticaria (PCD). The chronic nature of HE presents a substantial management challenge, often underestimated, leading to delayed treatment and potential progression to chronic hand eczema (CHE). Beyond individual health implications, HE exerts a profound impact on occupational, domestic, social, and psychological aspects, establishing itself as the most prevalent occupation-related skin disease. This paper seeks to establish a comprehensive classification system for HE, integrating clinical, dermoscopic, and histological elements. Dermoscopy, specifically, proves instrumental in distinguishing HE from palmar psoriasis, revealing characteristic features such as yellow scales and irregular vessels. Histopathological findings underscore the dynamic changes observed from acute to chronic stages, while challenges in differentiating hyperkeratotic HE from psoriasis underscore the necessity for a holistic diagnostic approach.
Conclusions: Accurate diagnosis and effective management of HE necessitate a holistic perspective that recognizes the inherent complexities of this inflammatory skin disease. By providing a multidimensional classification system, incorporating clinical, dermoscopic, and histological parameters, this paper aimed to contribute to a more nuanced understanding of HE and facilitate improved approaches to its diagnosis and treatment.
简介:手部湿疹(HE)是一种常见的炎症性皮肤病,影响 15-20% 的人,发病率约为 7.3 例/1000 人/年。这种疾病具有明显的性别差异,女性发病率更高。HE 的临床表现以瘙痒性红斑、水肿、哭泣性斑块、水泡和/或水疱为特征,具有相当大的异质性:在 Medline、Pubmed、Scopus 和 Cochrane 图书馆等多个数据库中进行了文献检索。检索时使用了以下关键词和医学主题词(MeSH):"手"、"湿疹"、"皮炎"、"皮肤镜 "和 "组织学",并使用布尔术语 "AND "来组合研究术语,以获得最佳搜索精度。文章筛选采用了 PRISMA 算法。检索范围包括截至 2023 年 10 月 1 日发表的手稿:多达 50% 的 HE 病例与特应性皮炎有关,强调了各种皮肤病之间复杂的相互作用。特应性湿疹的常见亚型包括刺激性接触性皮炎(ICD)、过敏性接触性皮炎(ACD)、特应性手部湿疹(AHE)和蛋白接触性皮炎/接触性荨麻疹(PCD)。手部湿疹的慢性特性给治疗带来了巨大挑战,而且往往被低估,导致治疗延误,并有可能发展为慢性手部湿疹(CHE)。除了对个人健康的影响外,手部湿疹还对职业、家庭、社会和心理产生深远影响,是最普遍的职业相关皮肤病。本文试图为手部湿疹建立一个全面的分类系统,将临床、皮肤镜和组织学要素整合在一起。皮肤镜检查尤其有助于区分 HE 和掌跖银屑病,可发现黄色鳞屑和不规则血管等特征。组织病理学发现强调了从急性到慢性阶段观察到的动态变化,而将角化过度性 HE 与银屑病区分开来的挑战则强调了采用整体诊断方法的必要性:结论:要对 HE 进行准确诊断和有效管理,就必须从整体角度认识这种炎症性皮肤病的内在复杂性。本文提供了一个结合临床、皮肤镜和组织学参数的多维分类系统,旨在帮助人们更深入地了解 HE,并改进其诊断和治疗方法。
{"title":"Hand eczema: a review of clinical, dermoscopic and histological features.","authors":"Elena Zappia, Nicole Macagno, Pietro Quaglino, Gabriele Roccuzzo, Simone Ribero","doi":"10.23736/S2784-8671.24.07879-4","DOIUrl":"https://doi.org/10.23736/S2784-8671.24.07879-4","url":null,"abstract":"<p><strong>Introduction: </strong>Hand eczema (HE) is a prevalent inflammatory skin condition, impacting 15-20% of individuals, with a notable incidence rate of approximately 7.3 cases per 1000 person/years. This condition exhibits significant gender-based variability, with a higher prevalence in females. The clinical presentation of HE is characterized by pruritic erythematous, edematous, weeping plaques, vesicles, and/or bullae, showcasing considerable heterogeneity.</p><p><strong>Evidence acquisition: </strong>A literature search was conducted across multiple databases, including Medline, Pubmed, Scopus, and the Cochrane Library. The search was conducted using the following key words and medical subject heading (MeSH) terms: \"hand,\" \"eczema,\" \"dermatitis,\" \"dermoscopy,\" and \"histology,\" employing the Boolean term \"AND\" to combine the research terms for optimal search precision. PRISMA algorithm has been used for article screening. The search scope included manuscripts published up to October 1, 2023.</p><p><strong>Evidence synthesis: </strong>Up to 50% of HE cases are associated with atopic dermatitis, emphasizing the complex interplay between various dermatological conditions. Common subtypes of HE include irritant contact dermatitis (ICD), allergic contact dermatitis (ACD), atopic hand eczema (AHE), and protein contact dermatitis/contact urticaria (PCD). The chronic nature of HE presents a substantial management challenge, often underestimated, leading to delayed treatment and potential progression to chronic hand eczema (CHE). Beyond individual health implications, HE exerts a profound impact on occupational, domestic, social, and psychological aspects, establishing itself as the most prevalent occupation-related skin disease. This paper seeks to establish a comprehensive classification system for HE, integrating clinical, dermoscopic, and histological elements. Dermoscopy, specifically, proves instrumental in distinguishing HE from palmar psoriasis, revealing characteristic features such as yellow scales and irregular vessels. Histopathological findings underscore the dynamic changes observed from acute to chronic stages, while challenges in differentiating hyperkeratotic HE from psoriasis underscore the necessity for a holistic diagnostic approach.</p><p><strong>Conclusions: </strong>Accurate diagnosis and effective management of HE necessitate a holistic perspective that recognizes the inherent complexities of this inflammatory skin disease. By providing a multidimensional classification system, incorporating clinical, dermoscopic, and histological parameters, this paper aimed to contribute to a more nuanced understanding of HE and facilitate improved approaches to its diagnosis and treatment.</p>","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141748123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}