Italian Journal of Dermatology and Venereology最新文献

Background: Nail alterations are rarely given significant importance in general consultation, but they are frequent especially in patients with chronic leg ulcers (CLU).

Methods: We performed a cross-sectional observational study enrolling all outpatients referring to our Dermatologic Open Injury Outpatient Service between January 2024 and September 2024 with a diagnosis of chronic leg ulcer comparing the prevalence of nail disorders with a healthy population.

Results: We identified nail alterations, including onychomycosis, pachyonychia, onychogryphosis, cuticle hyperkeratosis, associated with different systemic conditions.

Conclusions: We underlined the importance of nail examination in patients with CLU for the correct diagnosis and a best management of several vascular and/or systemic diseases.

Background: The role of socioeconomic status (SES) in the individual risk of contracting scabies in industrialized countries has not been specifically examined. This study aimed to assess potential associations between SES and scabies diagnosis.

Methods: The SES of a retrospective cohort of subjects residing in the province of Ferrara, north-east Italy, who were diagnosed with scabies between 2016 and 2024, was evaluated. SES was represented through an ecological-based deprivation index that identified five subgroups, ranging from I (highest SES) to V (lowest SES).

Results: A total of 307 subjects (188 males, ages ranging from 0 to 93 years) received a diagnosis of scabies at the local Dermatology Unit during the study period. The number of scabies diagnoses gradually increased. The distribution of patients across SES quintiles closely mirrored that of the general population in the same geographical area. However, scabies patients were more likely to belong to the two most deprived classes (IV and V) than to the highest SES classes (I and II) (P<0.001).

Conclusions: Scabies is a widespread infestation that can affect anyone, regardless of their SES. Nevertheless, belonging to lower SES classes appears to increase the risk of contracting scabies: to a greater extent, scabies tends to affect individuals from more deprived backgrounds.

Pediatric psoriasis is a chronic inflammatory skin disorder which impacts lifetime health and is associated with potentially long-lasting morbidities. While the association between psoriasis and metabolic syndrome has been extensively studied, including in children, a comprehensive understanding of other comorbidities in the pediatric population remains limited. This paper aims to provide an updated review of pediatric psoriasis-associated comorbidities, extending beyond the scope of metabolic syndrome. The primary objective of this review is to elucidate the diverse spectrum of comorbidities linked to pediatric psoriasis, highlighting emerging research and identifying gaps in current knowledge. The multifaceted nature of pediatric psoriasis-associated comorbidities rationalizes a holistic approach for clinical management. The identified gaps in current knowledge warrant further investigation to enhance our understanding of the relationships between pediatric psoriasis and associated health outcomes.

Background: Hereditary hemorrhagic telangiectasia (HHT) is a genetic vascular disorder characterized by epistaxis, mucocutaneous telangiectasias, and visceral arteriovenous malformations (AVMs). Despite the central role of dermatologic manifestations in diagnosis, there is a lack of comprehensive studies examining these features in large HHT populations. The aim of this paper is to describe the clinical and dermatologic features of a cohort of HHT patients, focusing on the prevalence, distribution, and morphology of mucocutaneous telangiectasias using videodermatoscopy, and to analyze their correlations with systemic manifestations such as epistaxis and visceral AVMs. In addition, the study examines genetic profiles and introduces the HHT Skin Score, a tool to quantify cutaneous involvement.

Methods: From March 2018 to March 2022, we enrolled a cohort of 62 HHT patients who met the Curaçao diagnostic criteria for definite HHT. Dermatologic assessments included comprehensive examinations, including videodermatoscopic evaluation of cutaneous telangiectasia morphology. Statistical analyses examined associations between telangiectasia distribution, epistaxis severity, presence of pulmonary and hepatic AVMs, and genetic mutations.

Results: Sixty-two patients were evaluated. The areas affected by cutaneous telangiectasias in at least 60% of the patients were the lips (79%), tongue (75.8%), ears (61.3%), and fingertips (71%). Videodermatoscopic image analysis revealed three distinct morphologic variants of telangiectasias: macular/papular, papular, and arborizing. Papular telangiectasias on the lips and tongue were strongly associated with pulmonary AVMs, whereas oral telangiectasias correlated with hepatic AVMs. The HHT Skin Score, developed to quantify the severity of the dermatologic manifestations, showed a significant correlation with the severity of epistaxis.

Conclusions: This study highlights the importance of dermatologic evaluation in HHT and provides a detailed characterization of the patient population. Mucocutaneous telangiectasias and genetics have a predictive value and may help to tailor clinical surveillance. The HHT Skin Score emerged as a collateral outcome, offering a quantitative framework for evaluating cutaneous involvement and its clinical significance.