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Association Between Slowly Conducting Anatomical Isthmuses and Ventricular Tachycardia Inducibility in Tetralogy of Fallot 慢传导解剖峡部与法洛四联症室性心动过速诱导的关系。
IF 7.7 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2026-01-01 DOI: 10.1016/j.jacep.2025.08.008
Victor Waldmann MD, PhD , Jeremy P. Moore MD, MS , Francis Bessière MD, PhD , Nawel Babouri MD , Mitchell I. Cohen MD , Edward T. O’Leary MD , Nimesh S. Patel MD , Babak Nazer MD , Weiyi Tan MD , Frank A. Fish MD , Aarti Dalal MD , Elisabetta Mariucci MD, PhD , Reina B. Tan MD , Michael S. Lloyd MD , Christopher J. McLeod MBChB, PhD , Charles C. Anderson MD , Ronald J. Kanter MD , Bryce V. Johnson MD , Bo Wang MD , Philip M. Chang MD , Paul Khairy MD, PhD

Background

Catheter ablation of sustained monomorphic ventricular tachycardia (SMVT) guided by the identification of slowly conducting anatomical isthmuses (SCAIs) has been proposed to mitigate the risk of ventricular tachycardia in tetralogy of Fallot (TOF). However, the prevalence and clinical significance of SCAI remain uncertain.

Objectives

This study aimed to assess the association between SCAI and SMVT inducibility in patients with TOF.

Methods

A multicenter international cohort with retrospective (2017-2021) and prospective (commencing 2021) components enrolled patients with TOF referred for electrophysiological study before transcatheter pulmonary valve replacement. The proportion with SCAI and its association with SMVT inducibility were analyzed.

Results

A total of 162 patients (mean age 39.5 ± 14.2 years; 57.4% male) were included. SMVT was induced in 42 (25.9%) patients, and ≥1 SCAI was present in 76 (46.9%) patients. The prevalence of SCAI was higher in patients with inducible SMVT (78.6% vs 31.1%; P < 0.001). However, 21.4% of patients with inducible SMVT had normally conducting anatomical isthmus (14.3%) or a non–anatomical isthmus substrate (7.1%). The area under the curve of SCAI in predicting SMVT inducibility was 0.71 (sensitivity 78.6%; specificity 64.2%). Although SCAI was independently associated with SMVT (OR: 6.4; 95% CI: 2.6-18.2), the association with other clinical parameters improved prediction of SMVT inducibility.

Conclusions

SCAI is highly prevalent in patients with TOF and is associated with inducible SMVT. However, the proportion of SCAI in noninducible patients is substantial, and some inducible patients have no SCAI. These findings suggest that SCAI alone is insufficient for arrhythmia management decisions, highlighting the need for an integrative approach combining electrophysiological study with other clinical parameters.
背景:在缓慢传导解剖峡部(SCAIs)识别的指导下,导管消融持续性单形态性室性心动过速(SMVT)已被提出以降低法洛四联症(TOF)室性心动过速的风险。然而,SCAI的患病率和临床意义仍不确定。目的:本研究旨在评估TOF患者SCAI与SMVT诱导性之间的关系。方法:采用回顾性(2017-2021)和前瞻性(2021年开始)的多中心国际队列,纳入经导管肺瓣膜置换术前转介的TOF患者进行电生理研究。分析SCAI的比例及其与SMVT诱导性的关系。结果:共纳入162例患者,平均年龄39.5±14.2岁,男性57.4%。42例(25.9%)患者诱发SMVT, 76例(46.9%)患者存在≥1例SCAI。诱导型SMVT患者SCAI患病率较高(78.6% vs 31.1%; P < 0.001)。然而,21.4%的诱导型SMVT患者有正常传导的解剖峡(14.3%)或非解剖峡底(7.1%)。SCAI预测SMVT诱导的曲线下面积为0.71(敏感性78.6%,特异性64.2%)。虽然SCAI与SMVT独立相关(OR: 6.4; 95% CI: 2.6-18.2),但与其他临床参数的关联提高了SMVT诱导性的预测。结论:SCAI在TOF患者中非常普遍,并与诱导性SMVT相关。然而,SCAI在非诱导患者中所占比例很大,一些诱导患者没有SCAI。这些发现表明,仅SCAI不足以做出心律失常的管理决策,强调需要将电生理研究与其他临床参数相结合的综合方法。
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引用次数: 0
Elimination of Ventricular Tachycardia and Premature Ventricular Contractions by Ablation of Oppositely Directed Re-Entrant Circuits 消融术消除室性心动过速和室性早搏。
IF 7.7 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2026-01-01 DOI: 10.1016/j.jacep.2025.09.001
Ryuichi Usui MD , Yuka Oda MD, PhD , Yuki Komatsu MD, PhD , Kikuya Uno MD, PhD , Akihiko Nogami MD, PhD
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引用次数: 0
Electrode Thermal Profile During Ventricular RF Ablation 心室射频消融期间的电极热谱:电极组织界面的新指示,以通知能量传递。
IF 7.7 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2026-01-01 DOI: 10.1016/j.jacep.2025.09.008
Daisuke Togashi MD, Yumi Katsume MD, Salah H. Alahwany MD, Giovanni E. Davogustto MD, Zachary T. Yoneda MD, Travis D. Richardson MD, Jay A. Montgomery MD, Sharon Shen MD, Juan C. Estrada MD, Arvindh N. Kanagasundram MD, Harikrishna Tandri MD, William G. Stevenson MD

Background

Electrode–tissue contact and orientation influence radiofrequency (RF) ablation heating, lesion size, and steam pops, and is not easily assessed. A catheter with 6 distal electrode temperature sensors provides thermal profiles that may help clarify electrode–tissue interactions.

Objectives

The aim of this study was to evaluate the relationships between thermal profiles, catheter orientation, impedance fall, steam pops, and discordant temperature–impedance changes during ventricular RF ablation.

Methods

We analyzed 2,085 RF applications in 100 patients, titrating power to a maximum temperature <50 °C and impedance fall >10 Ω. Stable thermal profiles were classified as embedded, central, or peripheral. Catheter orientation from the force vector was classified as perpendicular, oblique, or parallel.

Results

The thermal profile aligned with the force vector at 60.9% of stable sites, with 72.1% of peripheral profiles being oblique/parallel and 80.4% of central profiles being perpendicular. Impedance fall was discordant with temperature at 890 (42.7%) sites. Catheter orientation and thermal profiles differed for low temperature-high impedance fall, compared with high temperature-low impedance fall discordant sites (P < 0.001). An embedded thermal profile (all sensors ≥45 °C) most often occurred with perpendicular or oblique orientations, had the greatest impedance falls, and had the highest incidence of steam pops (8.6% vs 1.3%; P < 0.001). No steam pops occurred with impedance falls <14 Ω or maximum temperature <45.8 °C, or when impedance fall and temperature were discordant.

Conclusions

Electrode thermal profiles provide information complementary to force vector and impedance, reflecting electrode–tissue interactions that are also related to discrepancies in impedance fall and temperature during RF ablation. They can potentially help optimize RF ablation lesion size while avoiding steam pops.
背景:电极组织接触和取向影响射频(RF)消融加热、病变大小和蒸汽爆裂,并且不容易评估。带有6个远端电极温度传感器的导管提供热剖面,可能有助于澄清电极与组织的相互作用。目的:本研究的目的是评估心室射频消融过程中热分布、导管定向、阻抗下降、蒸汽爆裂和不一致的温度-阻抗变化之间的关系。方法:我们分析了100例患者的2085个射频应用,滴定功率至最高温度10 Ω。稳定的热剖面被分为嵌入式、中央或外围。根据力向量将导管定向分为垂直、倾斜或平行。结果:60.9%的稳定部位热剖面与力矢量对齐,72.1%的周边剖面为斜/平行,80.4%的中心剖面为垂直。890个(42.7%)位点的阻抗下降与温度不一致。与高温-低阻抗下降不一致的部位相比,低温-高阻抗下降的导管定向和热分布不同(P < 0.001)。嵌入式热剖面(所有传感器≥45°C)最常发生在垂直或倾斜方向,阻抗下降最大,蒸汽爆裂发生率最高(8.6% vs 1.3%; P < 0.001)。结论:电极热分布图提供了力矢量和阻抗的补充信息,反映了电极与组织的相互作用,也与射频消融过程中阻抗下降和温度的差异有关。它们可以潜在地帮助优化射频消融损伤的大小,同时避免蒸汽爆裂。
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引用次数: 0
From Silence to Storm 从沉默到风暴:神经丛蛋白信号作为治疗的十字路口。
IF 7.7 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2026-01-01 DOI: 10.1016/j.jacep.2025.09.031
Xiao Liu MD, PhD, Peng-Sheng Chen MD
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引用次数: 0
Ultra-Low Temperature Cryoablation Combined With Pulsed Field Ablation in a Swine Ventricular Infarct Model 超低温冷冻消融联合脉冲场消融在猪心室梗死模型中的应用。
IF 7.7 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2026-01-01 DOI: 10.1016/j.jacep.2025.09.017
Thomas A. Dewland MD, Ramkumar Venkateswaran MD, Satoshi Higuchi MD, Chanhee Lee MD, Edward P. Gerstenfeld MD

Background

Treatment of ventricular arrhythmias with radiofrequency catheter ablation can be challenging due to insufficient ablation efficacy in scar. The performance of ultra-low temperature cryoablation (ULTC) and combined ULTC + pulsed field ablation (PFA) has not been studied in ventricular tissue.

Objectives

This study sought to compare ventricular lesion size between ULTC alone and combined ULTC+PFA.

Methods

A total of 5 swine underwent chronic infarction via 120-minute balloon occlusion of the left anterior descending coronary artery. Three ablation approaches were tested: single 2-minute freeze (ULTC-1), 2 sequential 2-minute freezes delivered in a freeze-thaw-freeze cycle (ULTC-2), and a single 2-minute freeze with 8 PFA trains (ULTC-1+PFA).

Results

A total of 36 lesions (7 ULTC-1, 14 ULTC-2, 15 ULTC-1+PFA lesions) were applied to the left ventricular endocardium in 5 swine. Median (Q1-Q3) width was 9 (7-13) mm in healthy tissue and 11 (9-14) mm in scar (P = 0.18). In both healthy and scar tissue, lesion width was larger with ULTC-2 and with ULTC-1+PFA when compared with ULTC-1 alone. Lesion depth was 11 (9-15) mm in healthy tissue and 11 (8-13) mm in scar (P = 0.57). Lesion depth trended deeper with ULTC-2 and with ULTC-1+PFA. Within scar, zero of the ULTC-1, 13% of the ULTC-2 lesions, and 67% of the ULTC-1+PFA lesions were transmural.

Conclusions

ULTC resulted in clinically substantial lesions in healthy and infarcted ventricular myocardium. The addition of PFA to ULTC allowed for larger and more transmural lesions compared with a single ULTC ablation alone while avoiding the longer ablation times associated with 2 successive freezes.
背景:射频导管消融治疗室性心律失常具有挑战性,因为瘢痕消融效果不足。超低温冷冻消融(ULTC)和超低温冷冻消融+脉冲场消融(PFA)在心室组织中的作用尚未得到研究。目的:本研究旨在比较单独ULTC和联合ULTC+PFA的心室病变大小。方法:采用球囊阻断左冠状动脉前降支120分钟,对5头猪进行慢性梗死治疗。测试了三种消融方法:单次2分钟冻结(ULTC-1),在冻融循环中连续两次2分钟冻结(ULTC-2),单次2分钟冻结与8个PFA序列(ULTC-1+PFA)。结果:5头猪左室心内膜共行36个病变(7个ULTC-1, 14个ULTC-2, 15个ULTC-1+PFA病变)。健康组织的中位宽度(Q1-Q3)为9 (7-13)mm,疤痕组织的中位宽度为11 (9-14)mm (P = 0.18)。在健康组织和疤痕组织中,与单独使用ULTC-1相比,ULTC-2和ULTC-1+PFA的病变宽度更大。健康组织的病变深度为11 (9 ~ 15)mm,瘢痕组织的病变深度为11 (8 ~ 13)mm (P = 0.57)。ULTC-2和ULTC-1+PFA的病变深度更深。在瘢痕内,0个ULTC-1、13%的ULTC-2和67%的ULTC-1+PFA病变是跨壁性的。结论:ULTC可导致健康和梗死心室心肌的临床实质病变。与单独的ULTC消融相比,在ULTC中添加PFA可以治疗更大、更多的跨壁病变,同时避免了两次连续冻结相关的更长的消融时间。
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引用次数: 0
Full Issue PDF 完整版PDF
IF 7.7 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2026-01-01 DOI: 10.1016/S2405-500X(25)01073-4
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引用次数: 0
Evaluating the Impact of Obesity and Epicardial Adiposity on the Presence of HFpEF in Patients With AF 评估肥胖和心外膜肥胖对房颤患者HFpEF存在的影响。
IF 7.7 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2026-01-01 DOI: 10.1016/j.jacep.2025.08.011
Jonathan P. Ariyaratnam MB BChir, PhD , Adrian D. Elliott PhD , Ricardo S. Mishima MD, PhD , Jenelle K. Dziano BClinExPhys (Hons) , Mehrdad Emami MD, PhD , Jackson O. Howie MClinExPhys , Melissa E. Middeldorp MPH, PhD , Prashanthan Sanders MBBS, PhD

Background

Heart failure with preserved ejection fraction (HFpEF) is common in atrial fibrillation (AF). The mechanisms underlying HFpEF in AF remain unclear.

Objectives

This study sought to assess the influence of obesity and epicardial adipose tissue (EAT) on the presence of HFpEF in AF.

Methods

Consecutive patients with symptomatic AF and preserved ejection fraction undergoing an AF ablation procedure were recruited. Participants were classified as obese if body mass index (BMI) was ≥30 kg/m2. Diagnosis of HFpEF was made according to invasive measurement of mean left atrial pressure (mLAP). Mean right atrial pressures (mRAP) were measured to assess extrinsic pericardial restraint. Left atrial function was assessed by means of electroanatomic mapping and transthoracic echocardiography. Total cardiac volumes (TCV) and EAT volumes (EATV) were assessed with the use of cardiac computed tomography scans.

Results

Of 120 participants, 44 (36.7%) were obese and 76 (63.3%) were nonobese. Obese patients were younger than nonobese patients (P = 0.003). Obese patients demonstrated higher mLAP (P < 0.001) and were more likely to have HFpEF (P = 0.043). Obese patients also demonstrated higher mRAP (P < 0.001). However, there were no differences in global LA voltages (P = 0.186) or LA reservoir strain (P = 0.63). TCV (P = 0.001) and EATV (P < 0.001) were significantly greater in obese patients, and both correlated positively with mRAP (TCV: P = 0.013; EATV: P = 0.007).

Conclusions

Obesity in AF is associated with worse hemodynamics and higher prevalence of HFpEF, underpinned by greater pericardial restraint due to cardiomegaly and increased EATV. Patients with obesity and increased EATV are therefore at increased risk of HF and may benefit from additional HFpEF and weight loss therapies to reduce this risk (Characterizing Left Atrial Function and Compliance in Atrial Fibrillation; ACTRN12620000639921)
背景:心力衰竭伴保留射血分数(HFpEF)在房颤(AF)中很常见。房颤中HFpEF的机制尚不清楚。目的:本研究旨在评估肥胖和心外膜脂肪组织(EAT)对房颤中HFpEF存在的影响。方法:连续招募有症状的房颤患者和保留射血分数的房颤消融手术患者。如果体重指数(BMI)≥30 kg/m2,则被归类为肥胖。根据有创测量平均左心房压(mLAP)诊断HFpEF。测量平均右心房压(mRAP)以评估外源性心包约束。通过电解剖图和经胸超声心动图评估左房功能。使用心脏计算机断层扫描评估总心脏容积(TCV)和EAT容积(EATV)。结果:在120名参与者中,44人(36.7%)肥胖,76人(63.3%)非肥胖。肥胖患者年龄小于非肥胖患者(P = 0.003)。肥胖患者mLAP较高(P < 0.001), HFpEF发生率较高(P = 0.043)。肥胖患者也表现出较高的mRAP (P < 0.001)。然而,总体LA电压(P = 0.186)和LA库菌株(P = 0.63)没有差异。肥胖患者TCV (P = 0.001)和EATV (P < 0.001)显著高于肥胖患者,且两者与mRAP呈正相关(TCV: P = 0.013; EATV: P = 0.007)。结论:房颤患者的肥胖与更差的血流动力学和更高的HFpEF患病率相关,这是由心脏肥大和增加的EATV引起的更大的心包约束所支持的。因此,肥胖和EATV升高的患者HF的风险增加,可能受益于额外的HFpEF和减肥治疗来降低这种风险(心房颤动左心房功能和依从性特征;ACTRN12620000639921)。
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引用次数: 0
Prevalence of Peridevice Leak in Patients With Left Atrial Appendage-Occlusion vs Without Electrically Isolated Left Atrial Appendage 左心耳闭塞与无电隔离左心耳患者围装置泄漏的发生率。
IF 7.7 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2026-01-01 DOI: 10.1016/j.jacep.2025.08.027
Sanghamitra Mohanty MD, MS , Prem Geeta Torlapati MD, MPH , Vincenzo Mirco La Fazia MD , Rashi Sharma MD , Carola Gianni MD, PhD , Amin Al-Ahmad MD , John D. Burkhardt MD , G.J. Gallinghouse MD , Rodney Horton MD , John Allison MD , Weeranun Bode MD , Luigi Di Biase MD, PhD , Andrea Natale MD

Background

Peridevice leak (PDL) is commonly observed after Watchman implantation for left atrial appendage occlusion (LAAO) in atrial fibrillation (AF). Because the LAA is actively contractile, it is fair to assume that some degree of device shifting could occur because of LAA contraction during the initial period of device implantation.

Objectives

This study examined PDL prevalence in Watchman patients with vs without electrical isolation of LAA that consequentially leads to loss of contractility of the appendage.

Methods

Consecutive patients with AF undergoing the Watchman procedure were included in the study and prospectively followed up. Based on prior LAA isolation (LAAI), patients were divided into Group 1 (prior LAAI) and Group 2 (no LAAI). In all patients in Group 1, electroanatomical mapping and transesophageal echocardiogram (TEE) were used to confirm LAAI and absence of contractility of the appendage before the Watchman implantation. Repeat TEE was scheduled at 45 to 60 days’ post-Watchman implantation to assess for PDL on color Doppler. The leaks were reassessed by computed tomography imaging at 6 months. If leaks were detected during the first follow-up TEE, another TEE/computed tomography imaging was performed at 12 months to exclude persistent leak.

Results

A total of 495 patients were included in Group 1 and 810 in Group 2. Baseline characteristics were comparable between groups. At the first follow-up TEE at 45 to 60 days, leaks of any size were noted in 90 (18.2%) patients in Group 1 and 199 (24.6%) patients in Group 2 (P = 0.007). The majority of the leaks in Group 2 were ≥3 mm in size (Group 1: 26 [28.9%] vs Group 2: 109 [54.8%]; P < 0.001). Prior LAAI was found to be an independent predictor (OR: 0.662; 95% CI: 0.488-0.900; P = 0.008) of lower risk of leaks.

Conclusions

In this large prospective series of real-world patients, prior LAAI was seen to be associated with a lower risk of PDL in patients with AF and a Watchman device in situ.
背景:心房颤动(AF)左房耳闭塞(LAAO)患者Watchman植入术后常观察到围装置泄漏(PDL)。由于LAA处于主动收缩状态,我们可以假设在装置植入初期,LAA的收缩会导致一定程度的装置移位。目的:本研究检查了Watchman患者中没有电隔离LAA的vs,导致附属物收缩性丧失的PDL发病率。方法:连续接受Watchman手术的房颤患者纳入研究并进行前瞻性随访。根据LAA分离史(LAAI)将患者分为1组(有LAAI)和2组(无LAAI)。第一组所有患者在Watchman植入前均采用电解剖制图和经食管超声心动图(TEE)确认LAAI和附件无收缩性。watchman植入后45 ~ 60天再次TEE,彩色多普勒评价PDL。6个月时通过计算机断层成像重新评估渗漏。如果在第一次随访TEE期间检测到泄漏,则在12个月时进行另一次TEE/计算机断层成像以排除持续泄漏。结果:1组共495例,2组共810例。各组间基线特征具有可比性。在45 ~ 60天的第一次TEE随访中,1组90例(18.2%)患者和2组199例(24.6%)患者出现任何大小的渗漏(P = 0.007)。第2组大多数渗漏≥3mm(第1组:26 [28.9%]vs第2组:109 [54.8%];P < 0.001)。先前LAAI被发现是降低泄漏风险的独立预测因子(OR: 0.662; 95% CI: 0.488-0.900; P = 0.008)。结论:在这个现实世界患者的大型前瞻性系列中,先前的LAAI被认为与房颤患者原位Watchman装置发生PDL的风险较低相关。
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引用次数: 0
Ultrasound-Based Renal Sympathetic Denervation as Adjunctive Upstream Therapy During Atrial Fibrillation Ablation 基于超声的肾交感神经去断作为房颤消融过程中的辅助上游治疗:超hfib试点。
IF 7.7 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2026-01-01 DOI: 10.1016/j.jacep.2025.08.028
William Whang MD , Devi Nair MD , Rahul Bhardwaj MD , Marc Lahiri MD , Dinesh Sharma MD , Taisei Kobayashi MD , Shephal K. Doshi MD , Andrea Natale MD , Craig Moskowitz MD , Moussa Mansour MD , Vijay Swarup MD , Mohit K. Turagam MD , Srinivas Dukkipati MD , Matthew C. Hyman MD, PhD , Sanghamitra Mohanty MD, MS , Jeff Lam MS , Ugur Gurol BS , Carla Perdomo Silva BA , Vivek Y. Reddy MD

Background

During atrial fibrillation (AF) ablation, adjunctive renal denervation (RDN), by virtue of its effect on the sympathetic/renin-angiotensin-aldosterone axis, has improved AF control. However, patients in these studies mostly had uncontrolled hypertension.

Objectives

The aim of this study was to assess the effect of RDN using an ultrasound catheter to improve rhythm outcomes in patients with hypertension (including controlled hypertension) undergoing AF ablation.

Methods

This investigator-initiated, sham-controlled, single-blind randomized controlled U.S. Food and Drug Administration trial included first-ever paroxysmal or persistent AF ablation patients with histories of hypertension receiving ≥1 antihypertensive medication. Post–AF ablation randomization was 1:1 to RDN using a circumferential ultrasound system or sham control; patients with ineligible renal arterial anatomy were screen failures. The primary endpoint was 12-month freedom from AF or atrial flutter (AFL) (≥30 seconds) off antiarrhythmic medications after 90-day blanking.

Results

At 9 centers, 107 patients were randomized; excluding 7 screen failures, the 100-patient cohort (mean age 66 ± 9 years, 35% women, paroxysmal and persistent AF in 86% and 14%) underwent radiofrequency ablation (55%) or cryoablation (45%) for AF. The 1-year Kaplan-Meier estimates for freedom from AF or AFL were 49% for sham vs 67% for RDN (log-rank P = 0.17). In a Cox analysis adjusted for age, sex, and persistent AF, the HR for recurrent AF or AFL with RDN was 0.65 (95% CI: 0.32-1.31; P = 0.23). There were no RDN-related adverse events.

Conclusions

In this AF ablation cohort, adjunctive RDN was safe and reduced AF and AFL recurrence by 35%, an effect not reaching statistical significance in this pilot trial. A fully powered randomized trial is warranted to define the impact of RDN among patients planned for AF ablation.
背景:在房颤(AF)消融过程中,辅助性肾去神经支配(RDN)通过其对交感神经/肾素-血管紧张素-醛固酮轴的作用,改善了房颤的控制。然而,这些研究中的患者大多有未控制的高血压。目的:本研究的目的是评估使用超声导管RDN改善心房颤动消融高血压(包括控制高血压)患者心律结局的效果。方法:这项由研究者发起、假对照、单盲、随机对照的美国食品和药物管理局试验纳入了首次发作性或持续性房颤消融的高血压病史患者,接受≥1种降压药物治疗。房颤消融后随机分组为1:1 - RDN,采用周向超声系统或假对照;肾动脉解剖不合格的患者为筛查失败。主要终点是停用90天抗心律失常药物后12个月无房颤或心房扑动(AFL)(≥30秒)。结果:在9个中心,107例患者被随机分组;排除7例筛查失败,100例患者队列(平均年龄66±9岁,35%为女性,阵发性和持续性房颤分别为86%和14%)接受射频消融(55%)或冷冻消融(45%)治疗房颤。假手术1年房颤或房颤自由Kaplan-Meier估计为49%,RDN为67%(对数秩P = 0.17)。在校正了年龄、性别和持续性房颤的Cox分析中,复发性房颤或AFL合并RDN的HR为0.65 (95% CI: 0.32-1.31; P = 0.23)。没有rdn相关的不良事件。结论:在房颤消融队列中,辅助RDN是安全的,可使房颤和AFL的复发率降低35%,但在本试验中未达到统计学意义。有必要进行一项全功率随机试验,以确定RDN对计划进行房颤消融的患者的影响。
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引用次数: 0
Irregular A-H-V-H-V Pattern Arrhythmia 不规则A-H-V-H-V型心律失常
IF 7.7 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2026-01-01 DOI: 10.1016/j.jacep.2025.09.002
Atsushi Doi MD , Kazuki Moriwaki MD , Takuya Oshita MD , Takuya Tsukamoto MD , Naoko Takaoka MD , Toshiharu Iwamura MD , Takahiko Kawarabayashi MD , Daiju Fukuda MD
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引用次数: 0
期刊
JACC. Clinical electrophysiology
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