JACC. Clinical electrophysiology最新文献

{"title":"From Electrical to Thermal Insight","authors":"Felix Bourier MD","doi":"10.1016/j.jacep.2025.10.022","DOIUrl":"10.1016/j.jacep.2025.10.022","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":"12 1","pages":"Pages 13-15"},"PeriodicalIF":7.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145742560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PVC Location and Heart Failure","authors":"Hassan Adam Alhassan MBChB, MPH","doi":"10.1016/j.jacep.2025.10.035","DOIUrl":"10.1016/j.jacep.2025.10.035","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":"12 1","pages":"Page 181"},"PeriodicalIF":7.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146045276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of Left Atrial Appendage Occlusion in Patients With Prior Gastrointestinal Bleeds","authors":"Douglas Darden MD ,&nbsp;Aashish Katapadi MD ,&nbsp;Chien Yu Huang PhD ,&nbsp;Sarah Zimmerman MS ,&nbsp;Dhanunjaya Lakkireddy MD ,&nbsp;Rajesh Kabra MD ,&nbsp;Naga Venkata K. Pothineni MD ,&nbsp;Rakesh Gopinathannair MD ,&nbsp;Muhammad Bilal Munir MD ,&nbsp;James V. Freeman MD, MPH, MS ,&nbsp;Jonathan C. Hsu MD, MAS","doi":"10.1016/j.jacep.2025.09.009","DOIUrl":"10.1016/j.jacep.2025.09.009","url":null,"abstract":"<div><h3>Background</h3><div>Left atrial appendage occlusion (LAAO) is increasingly used as a stroke prevention strategy in patients with atrial fibrillation who have contraindications to oral anticoagulation, including prior gastrointestinal bleeding (GIB). However, the clinical risks and benefits of LAAO may differ substantially depending on the specific indication for the procedure, and outcomes in patients with prior GIB remain incompletely understood.</div></div><div><h3>Objectives</h3><div>The aim of this study was to evaluate in-hospital and long-term outcomes of LAAO in patients with prior GIB.</div></div><div><h3>Methods</h3><div>Using data from the National Cardiovascular Data Registry LAAO Registry, patients who underwent Watchman LAAO between January 2016 and December 2022 were analyzed. In-hospital and long-term adverse events, mortality, and postimplantation antithrombotic prescriptions were compared between patients with and those without prior GIB.</div></div><div><h3>Results</h3><div>Prior GIB was common (33.7%) in patients undergoing Watchman LAAO. These patients were older, had more comorbidities, and often underwent Watchman 2.5 (31.4% vs 41.3%) vs Watchman FLX (68.6% vs 58.7%) implantation than their non-GIB counterparts. After adjustment, prior GIB was associated with higher rates of in-hospital major complications (OR: 1.18; 95% CI: 1.10-1.26). At 45 days, these patients had increased risks for GIB (HR: 4.36; 95% CI: 4.07-4.66) and major bleeding (HR: 2.94; 95% CI: 2.74-3.16). At 1-year follow-up, they remained at significantly higher risk for GIB (HR: 3.84; 95% CI: 3.65-4.03), major bleeding (HR: 2.82; 95% CI: 2.67-2.98), and death (HR: 1.10; 95% CI: 1.06-1.14). Stroke risk was no different between groups. Overall, those with GIB were more likely to receive conservative postprocedural antithrombotic regimens, including higher rates of no antithrombotic agents, warfarin only, and dual antiplatelet therapy.</div></div><div><h3>Conclusions</h3><div>Patients with prior GIB undergoing LAAO experienced higher in-hospital complications and long-term risks for GIB and major bleeding, with no differences in stroke risk. This underscores the need for improved postprocedural strategies to mitigate bleeding risks.</div></div>","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":"12 1","pages":"Pages 119-130"},"PeriodicalIF":7.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145421778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Undiagnosed OSA in Patients With All Patterns of Atrial Fibrillation","authors":"Eric W. Mills MD, PhD ,&nbsp;Kyungah Im PhD ,&nbsp;Tamar Sofer PhD ,&nbsp;Julie B. Shea NP ,&nbsp;Thomas M. Tadros MD ,&nbsp;Paul C. Zei MD, PhD ,&nbsp;William H. Sauer MD ,&nbsp;David T. Martin MD ,&nbsp;Elliott M. Antman MD ,&nbsp;Sogol Javaheri MD, MPH","doi":"10.1016/j.jacep.2025.09.027","DOIUrl":"10.1016/j.jacep.2025.09.027","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":"12 1","pages":"Pages 171-173"},"PeriodicalIF":7.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145504277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Slow Conducting Anatomical Isthmus and VT Inducibility in Repaired Tetralogy of Fallot","authors":"Maully Shah MBBS ,&nbsp;Nico A. Blom MD, PhD","doi":"10.1016/j.jacep.2025.10.020","DOIUrl":"10.1016/j.jacep.2025.10.020","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":"12 1","pages":"Pages 41-43"},"PeriodicalIF":7.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145677584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Tale of 2 Tachycardias","authors":"Reginald T. Ho MD","doi":"10.1016/j.jacep.2025.09.019","DOIUrl":"10.1016/j.jacep.2025.09.019","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":"12 1","pages":"Pages 236-241"},"PeriodicalIF":7.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145421757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental Disorders Following Implantable Cardioverter-Defibrillator Therapy","authors":"Juwon Kim MD ,&nbsp;Hyewon Kim MD ,&nbsp;Hyunsoo Kim MS ,&nbsp;Ju Youn Kim MD, PhD ,&nbsp;Kyoung-Min Park MD, PhD ,&nbsp;Young Keun On MD, PhD ,&nbsp;Danbee Kang PhD ,&nbsp;Seung-Jung Park MD, PhD","doi":"10.1016/j.jacep.2025.09.006","DOIUrl":"10.1016/j.jacep.2025.09.006","url":null,"abstract":"<div><h3>Background</h3><div>The incidence and prognostic implications of mental disorders after implantable cardioverter-defibrillator (ICD) therapy remain underexplored.</div></div><div><h3>Objectives</h3><div>This study sought to investigate the incidence of newly diagnosed mental disorders after ICD implantation compared with the incidence in matched non-ICD control subjects and to evaluate the impact of these disorders on prognosis.</div></div><div><h3>Methods</h3><div>Using the Korean National Health Insurance Service database, 6,356 patients with an ICD and 17,664 propensity score–matched control subjects were selected between 2010 and 2020. In the ICD group, long-term prognosis was compared between patients with and without mental disorders newly diagnosed postimplantation.</div></div><div><h3>Results</h3><div>The 10-year cumulative incidence of newly diagnosed mental disorders was 37.3% in ICD patients, significantly higher than in the matched control subjects (34.5%; HR: 1.21; 95% CI: 1.14-1.29). The most frequent mental disorders were depressive disorder (18.4%), insomnia (16.8%), and anxiety disorder (5.8%). Among ICD patients, newly diagnosed mental disorders adversely affected long-term prognosis, with significantly higher all-cause mortality (HR: 2.00; 95% CI: 1.76-2.28), cardiac mortality (HR: 1.83; 95% CI: 1.53-2.18), severe heart failure events (HR: 2.12; 95% CI: 1.54-2.93), and any-cause readmissions (HR: 1.65; 95% CI: 1.50-1.82) compared with those without mental disorders. In particular, schizophrenia spectrum disorders and mental disorders diagnosed early (within 2.8 years’ postimplantation) were strongly associated with worse clinical outcomes. The adverse effect of mental disorders on mortality was more pronounced in patients with atrial fibrillation than in those without atrial fibrillation (<em>P</em>_interaction = 0.04).</div></div><div><h3>Conclusions</h3><div>Evidence-based ICD implantation, proactive screening, and timely management of mental disorders may mitigate adverse outcomes associated with ICD therapy and mental disorders.</div></div>","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":"12 1","pages":"Pages 141-155"},"PeriodicalIF":7.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145354759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tirzepatide and Cardiovascular Outcomes in Patients With Ventricular Tachycardia and Systolic Heart Failure","authors":"Aravinthan Vignarajah MD ,&nbsp;Min Choon Tan MD ,&nbsp;Tanusha Winson MBBS ,&nbsp;Nishanthi Vigneswaramoorthy MD ,&nbsp;Hicham El Masry MD ,&nbsp;Jakub Sroubek MD ,&nbsp;Pasquale Santangeli MD ,&nbsp;Justin Z. Lee MD","doi":"10.1016/j.jacep.2025.09.038","DOIUrl":"10.1016/j.jacep.2025.09.038","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":"12 1","pages":"Pages 168-170"},"PeriodicalIF":7.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145504337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulsed-Field Ablation on Mitral Isthmus With the Pentaspline Catheter: Long Term Efficacy and Durability.","authors":"Wael Zaher, Baptiste Davong, Mehdi Abdelali, Jean-Paul Albenque, Nicolas Combes, Domenico G Della Rocca, Gian-Battista Chierchia, Carlo de Asmundis, Stéphane Combes, Serge Boveda","doi":"10.1016/j.jacep.2025.11.026","DOIUrl":"https://doi.org/10.1016/j.jacep.2025.11.026","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":" ","pages":""},"PeriodicalIF":7.7,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145989290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Neovascular Conduit Creation for Cardiac Implantable Electronic Device Implantation in Chronic Venous Occlusions.","authors":"Alan Sugrue, Ammar M Killu, Nicholas Y Tan, Arashk Motiei, Siva Mulpuru, Paul Friedman, Abhishek Deshmukh, Jason Anderson","doi":"10.1016/j.jacep.2025.11.020","DOIUrl":"https://doi.org/10.1016/j.jacep.2025.11.020","url":null,"abstract":"","PeriodicalId":14573,"journal":{"name":"JACC. Clinical electrophysiology","volume":" ","pages":""},"PeriodicalIF":7.7,"publicationDate":"2025-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145911564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}