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Gastric cancer and associated pathogens: is there any association in Moroccan region? 胃癌与相关病原体:摩洛哥地区是否存在关联?
IF 1.3 4区 医学 Q4 INFECTIOUS DISEASES Pub Date : 2024-10-31 DOI: 10.7883/yoken.JJID.2024.147
Samia Alaoui Boukhris, Mounia El Khadir, Safae Karim, Tiatou Souho, Dafr-Allah Benajah, Sidi Adil Ibrahimi, Laila Chbani, Mohamed El Abkari, Bahia Bennani

Helicobacter pylori, Epstein-Barr virus and human papillomavirus are three pathogens associated with various human cancers. This study aimed to investigate the role of these pathogens in gastric cancer in Moroccan population. For this, a retrospective study has been conducted on participants attending the gastroenterology department of Hassan II University Hospital of Fez. A total of 279 participants were enrolled. H. pylori, EBV and HPV were detected and genotyped by PCR. In results, a significant association has been established between H. pylori, EBV and gastric cancer. 93.4% and 43.3% of gastric cancer cases are related to H. pylori and EBV respectively (p≤0.01). H. pylori-EBV co-infection is responsible of 31.6% of gastric cancer cases (p<0.01). Correlation between pathogens genotypes and gastric cancer shows 54.6% of GC EBV positives are carrying the 30 bp deletion in LMP1gene, while 16% of gastric cancers cases are carrying high-risk genotypes of HPV (p=0.21). The obtained results highlight the possible role of co-infection in gastric cancer development.

幽门螺杆菌、Epstein-Barr 病毒和人类乳头瘤病毒是与各种人类癌症相关的三种病原体。本研究旨在调查这些病原体在摩洛哥人胃癌中的作用。为此,我们对在非斯哈桑二世大学医院消化科就诊的患者进行了回顾性研究。共有 279 人参加了这项研究。研究人员通过 PCR 对幽门螺杆菌、EBV 和 HPV 进行了检测和基因分型。结果显示,幽门螺杆菌、EBV 和胃癌之间存在明显的关联。93.4%和43.3%的胃癌病例分别与幽门螺杆菌和EBV有关(P≤0.01)。31.6%的胃癌病例与幽门螺杆菌和 EBV 共同感染有关(p
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引用次数: 0
Chemotactic activity of products of Elizabethkingia anophelis derived from Aedes albopictus against RAW264 murine macrophage cell line. 从白纹伊蚊中提取的 Elizabethkingia anophelis 产品对 RAW264 鼠巨噬细胞系的趋化活性。
IF 1.3 4区 医学 Q4 INFECTIOUS DISEASES Pub Date : 2024-10-31 DOI: 10.7883/yoken.JJID.2024.227
Satoru Yui, Norihiko Fujii, Jo Terauchi, Nana Tanabe, Marie Kanno, Kouta Umehara, Ryosuke Iijima, Riyo Kamata, Naoki Ohkura, Seishi Kishimoto, Toshinori Sasaki

Dengue viruses enter dermal macrophages which are derived from other tissues after mosquito bites. We examined chemotactic factors derived from the dengue vector mosquito, Aedes albopictus, toward a RAW264 murine macrophage cell line. We found that Elizabethkingia anophelis that was isolated from mosquitoes exhibited migration-inducing activity toward RAW264 cells. The active substances were extracted using ethyl acetate to induce chemotactic movements. Chemotactic activity was eluted in the several fractions using the reversed-phase chromatography, suggesting that multiple substances were responsible for the activity. We isolated three bacterial colonies from the wild A. albopictus mosquitoes collected in Toyama Park, Tokyo prefecture, Japan. The bacterial 16S rRNA gene sequences were the most similar to those of Lonsdalea quercina. These bacteria also exhibited migration-inducing activity toward RAW264 cells. The migration-inducing activity of mosquito bacteria might be a new aspect of mosquito-mediated viral infections.

登革热病毒会进入皮肤巨噬细胞,而巨噬细胞来自蚊子叮咬后的其他组织。我们研究了登革热病媒蚊子白纹伊蚊对 RAW264 小鼠巨噬细胞系的趋化因子。我们发现,从蚊子体内分离出来的伊丽莎白金丝楠对 RAW264 细胞具有迁移诱导活性。使用乙酸乙酯提取活性物质以诱导趋化运动。使用反相色谱法在多个馏分中都能洗脱出趋化活性,这表明该活性是由多种物质引起的。我们从日本东京都富山公园采集的野生白纹伊蚊中分离出三个细菌菌落。细菌的 16S rRNA 基因序列与 Lonsdalea quercina 最为相似。这些细菌对 RAW264 细胞也具有迁移诱导活性。蚊子细菌的迁移诱导活性可能是蚊子介导的病毒感染的一个新方面。
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引用次数: 0
Clinical Characteristics and Risk Factors for Severe Japanese Spotted Fever: A Retrospective Multicenter Study in Nagasaki Prefecture, Western Japan. 严重日本斑疹热的临床特征和风险因素:日本西部长崎县的一项回顾性多中心研究。
IF 1.3 4区 医学 Q4 INFECTIOUS DISEASES Pub Date : 2024-10-31 DOI: 10.7883/yoken.JJID.2024.216
Kohsuke Matsui, Shingo Masuda, Yosuke Koizumi, Monami Yamanaka, Yasumori Izumi, Chris Smith, Reiko Miyahara, Koya Ariyoshi

Japanese spotted fever (JSF) is a tick-borne rickettsial disease prevalent in western Japan, with an increasing incidence and geographical distribution. This retrospective study aimed to describe the clinical features of JSF and identify factors associated with its severe form. We included adult patients with laboratory confirmed JSF in Nagasaki prefecture from 2010 to 2021. Severe JSF was defined by the presence of altered mental status, low blood pressure, or low oxygen saturation. In total, 65 JSF cases were diagnosed. Common symptoms were fever (87%), rash (48%), and fatigue (48%) with eschars detected in 50 (79.4%) of patients. Thirty-eight (60.3%) patients were initially diagnosed with non-JSF conditions. Twenty-one (33.3%) cases were categorized as severe JSF, including one death. Pre-hospital factors associated with severe JSF included age ≥75 (adjusted odds ratio [aOR] 37.53, 95% confidence interval [CI] 3.03-465.38), male sex (aOR 26.5, 95% CI 4.23-166.00), and a treatment delay ≥4 days from onset (aOR 5.96, 95% CI 1.13-31.60). This study highlights diagnostic challenges of JSF due to its non-organ-specific clinical presentation. Delayed initial treatment, advanced age, and male sex significantly increase the risk of severity. It is crucial to further raise awareness of JSF among clinicians and residents in endemic areas.

日本斑疹热(JSF)是一种流行于日本西部的蜱传立克次体疾病,发病率和地理分布都在不断增加。这项回顾性研究旨在描述日本斑疹热的临床特征,并确定与其严重形式相关的因素。我们纳入了 2010 年至 2021 年长崎县实验室确诊的 JSF 成年患者。出现精神状态改变、低血压或低血氧饱和度即为重症 JSF。共诊断出 65 例 JSF。常见症状为发热(87%)、皮疹(48%)和乏力(48%),其中有 50 名患者(79.4%)检测到疱疹。38名患者(60.3%)最初被诊断为非 JSF 病症。21例(33.3%)被归类为严重JSF,其中1例死亡。与重症 JSF 相关的院前因素包括年龄≥75 岁(调整赔率比 [aOR]37.53,95% 置信区间 [CI]3.03-465.38)、性别为男性(aOR 26.5,95% CI 4.23-166.00)和发病后治疗延迟≥4 天(aOR 5.96,95% CI 1.13-31.60)。由于JSF的临床表现无器官特异性,这项研究凸显了JSF在诊断方面的挑战。延迟初始治疗、高龄和男性显著增加了病情严重的风险。进一步提高流行地区临床医生和居民对 JSF 的认识至关重要。
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引用次数: 0
Septic shock and death due to Dolosigranulum pigrum bacteremia: a case report. 猪多糖菌血症导致的脓毒性休克和死亡:病例报告。
IF 1.3 4区 医学 Q4 INFECTIOUS DISEASES Pub Date : 2024-10-31 DOI: 10.7883/yoken.JJID.2024.178
Sachiko Hakoda, Akira Ishiwata, Ryo Shimada, Shuji Hatakeyama, Makoto Kondo

We report the case of a 77-year-old Japanese woman with neuromyelitis optica spectrum disorder, treated with 15 mg of prednisolone daily, who presented with acute septic shock and altered consciousness due to Dolosigranulum pigrum bacteremia. Intravenous extracellular fluids and broad-spectrum antibiotics were administered as an initial treatment. However, the patient died shortly after admission. We performed 16S rRNA sequencing and analyzed the murJ gene. A phylogenetic tree constructed using the neighbor-joining method showed that the strain belonged to clade C3, according to the classification proposed by Flores Ramos et al. Although D. pigrum, a commensal bacterium of the upper respiratory tract, is rarely associated with infections, it occasionally causes serious infections. Accumulation of clinical and bacteriological data is crucial for understanding the pathogenicity and infections associated with this organism.

我们报告了一例患有神经脊髓炎视网膜谱系障碍的 77 岁日本妇女的病例,她每天接受 15 毫克泼尼松龙治疗,但因猪多糖菌血症而出现急性脓毒性休克和意识改变。最初的治疗方法是静脉注射细胞外液和广谱抗生素。然而,患者在入院后不久死亡。我们进行了 16S rRNA 测序并分析了 murJ 基因。根据弗洛雷斯-拉莫斯(Flores Ramos)等人提出的分类方法,用邻接法构建的系统发生树显示,该菌株属于 C3 支系。猪丹毒杆菌是上呼吸道的一种共生细菌,虽然很少与感染有关,但偶尔也会引起严重感染。积累临床和细菌学数据对于了解该病菌的致病性和相关感染至关重要。
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引用次数: 0
Investigation of the outbreak of Clostridium perfringens using single nucleotide polymorphism analysis for genotyping in Toyama, Japan, 2023. 利用单核苷酸多态性分析进行基因分型的日本富山梭状芽孢杆菌疫情调查,2023 年。
IF 1.3 4区 医学 Q4 INFECTIOUS DISEASES Pub Date : 2024-09-30 DOI: 10.7883/yoken.JJID.2024.189
Kazuki Saito, Keiko Kimata, Masanori Watahiki, Junko Isobe, Jun-Ichi Kanatani, Kaho Ikeda, Takashi Takeuchi, Chiharu Matsuzaki, Kazunori Oishi

Clostridium perfringens, which produces C. perfringens enterotoxin (CPE), is a major causative agent of food poisoning owing to its gastrointestinal symptoms. Genotyping is important for identifying the etiological agent in outbreaks of C. perfringens. We attempted to genotype strains isolated from an outbreak of food poisoning in Toyama in 2023 using single nucleotide polymorphism (SNP) analysis. The strains of C. perfringens were isolated from a piece of curry food consumed by all patients and from the feces of the patients and employees. The cpe gene was detected in isolates from patients and curry food. The cpe-negative isolates were found in patients who consumed curry foods and in employees. The results of the SNP analysis suggest that the patient- and curry-derived isolates were likely from the same source but were unlikely to be related to the employee-derived isolates. The results of the SNP and pulsed-field gel electrophoresis (PFGE) analyses were consistent, indicating that the patient- and curry-derived isolates came from the same source. SNP analysis, a whole-genome-based genotyping method, is a promising alternative to the traditional PFGE method. Further studies are needed to accumulate more experience with genotyping using SNP analysis for the epidemiological investigation of outbreaks of C. perfringens.

产生产气荚膜梭菌肠毒素(CPE)的产气荚膜梭菌因其胃肠道症状而成为食物中毒的主要致病菌。基因分型对于确定产气荚膜梭菌爆发的病原体非常重要。我们尝试利用单核苷酸多态性(SNP)分析对 2023 年富山爆发的食物中毒事件中分离出的菌株进行基因分型。从所有患者食用的咖喱食品以及患者和员工的粪便中分离出了产气荚膜杆菌菌株。从患者和咖喱食品中分离出的菌株都检测到了 cpe 基因。而在食用咖喱食品的患者和雇员体内则发现了 cpe 阴性的分离物。SNP 分析结果表明,患者和咖喱中的分离物可能来自同一来源,但与员工中的分离物不太可能有关联。SNP 分析和脉冲场凝胶电泳 (PFGE) 分析的结果一致,表明患者和咖喱分离物来自同一来源。SNP 分析是一种基于全基因组的基因分型方法,是传统 PFGE 方法的一种很有前途的替代方法。在利用 SNP 分析对产气荚膜杆菌疫情进行流行病学调查方面,还需要进一步的研究来积累更多的基因分型经验。
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引用次数: 0
SARS-CoV-2 IgG seroprevalence in the Okinawa Main Island and remote islands in Okinawa, Japan, 2020-2021. 2020-2021 年日本冲绳本岛和冲绳偏远岛屿的 SARS-CoV-2 IgG 血清流行率。
IF 1.3 4区 医学 Q4 INFECTIOUS DISEASES Pub Date : 2024-09-30 DOI: 10.7883/yoken.JJID.2023.255
Yoshihiro Takayama, Yusuke Shimakawa, Yoshiaki Aizawa, Christian Butcher, Naomi Chibana, Mary Collins, Kohei Kamegai, Tae Gyun Kim, Satoshi Koyama, Ryota Matsuyama, Melissa M Matthews, Tomoari Mori, Tetsuharu Nagamoto, Masashi Narita, Ryosuke Omori, Noriko Shibata, Satoshi Shibata, Souichi Shiiki, Shunichi Takakura, Naoki Toyozato, Hiroyuki Tsuchiya, Matthias Wolf, Taro Yamamoto, Shuhei Yokoyama, Sho Yonaha, Kenji Mizumoto

We estimated the seroprevalence of anti-SARS-COV-2 IgG in different island groups in Okinawa. A cross-sectional sero-survey was repeated in three periods between July 2020 and February 2021. A total of 2683 serum samples were collected from six referral medical centers, each covering a separate region in Okinawa. In the main island, the seroprevalence was 0.0% (0/392, 95% CI: 0.0-0.9), 0.6% (8/1448, 0.2-1.1), and 1.4% (8/582, 0.6-2.7) at the 1st, 2nd, and 3rd sero-survey, respectively. In the remote islands, the seroprevalence was 0.0% (0/144, 95% CI: 0.0-2.5) and 1.6% (2/123, 0.2-5.8) at the 2nd and 3rd survey, respectively. The case detection ratio was 2.7 (95% CI: 1.3-5.3) in the main island and 2.8 (0.7-11.1) in the remote islands during the 3rd survey. The case detection ratio was the highest in people aged 20-29 years (8.3, 95% CI: 3.3-21.4) in the main island and in those aged 50-59 years (14.1, 2.1-92.7) in the remote islands, suggesting under-reporting of clinical cases by the surveillance system in these subgroups. A sero-survey during an emerging infectious disease epidemic can be useful for validating the reliability of the surveillance system by providing the case detection ratio.

我们估算了冲绳岛不同岛群抗 SARS-COV-2 IgG 的血清流行率。我们在 2020 年 7 月至 2021 年 2 月期间分三次重复进行了横断面血清调查。共收集了 2683 份血清样本,这些样本分别来自冲绳的六个转诊医疗中心。在本岛,第一次、第二次和第三次血清调查的血清流行率分别为 0.0%(0/392,95% CI:0.0-0.9)、0.6%(8/1448,0.2-1.1)和 1.4%(8/582,0.6-2.7)。在偏远岛屿,第二次和第三次血清调查的血清流行率分别为 0.0%(0/144,95% CI:0.0-2.5)和 1.6%(2/123,0.2-5.8)。在第三次调查中,主岛的病例检出率为 2.7(95% CI:1.3-5.3),偏远岛屿为 2.8(0.7-11.1)。病例检出率在本岛 20-29 岁人群中最高(8.3,95% CI:3.3-21.4),在偏远岛屿 50-59 岁人群中最高(14.1,2.1-92.7),这表明监测系统对这些亚群的临床病例报告不足。在新出现的传染病流行期间进行血清调查可提供病例检出率,有助于验证监测系统的可靠性。
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引用次数: 0
Risk of death in old Japanese COVID-19 cases infected with the Omicron variant: a population-based study. 日本 COVID-19 老年病例感染 Omicron 变体的死亡风险:一项基于人群的研究。
IF 1.3 4区 医学 Q4 INFECTIOUS DISEASES Pub Date : 2024-09-30 DOI: 10.7883/yoken.JJID.2024.071
Hideo Tanaka, Yuki Takahashi, Yoshitaka Koga, Shunichi Takiguchi, Shigeru Ogimoto, Shizuyo Inaba, Hiroyuki Matsuoka, Yuka Miyajima, Takeshi Takagi, Fujiko Irie, Yoshihito Bamba, Fuyo Yoshimi, Tomoyuki Suzuki, Isao Araki, Chika Shirai, Sayuri Matsumoto, Toshiyuki Shibata, Hitomi Nagai, Masaru Kinoshita, Rie Fujita, Tsuyoshi Ogata

We assessed case fatality rates (CFRs) in cases aged ≥70 years in 10 Japanese prefectures (14.8 million residents) diagnosed between January 2022 and March 2023, when the Omicron variant was dominant in Japan. We selected incident reports on 283,052 study subjects from participating Public Health Centers adhering to the Infectious Diseases Control Law. Cases were passively followed up until the end of their isolation, date of death or 28 days after the COVID-19 diagnosis, whichever occurred first. We calculated age-standardized CFRs with 95% confidence intervals (CI) using the Japanese population aged 70-79, 80-89 and ≥90 in 2022 divided into 16 subgroups according to the period of COVID-19 diagnosis. The total overall CFR was 1.59% (95% CI 1.55-1.64); it ranged between 0.67% (95% CI 0.38-0.96, May 23-June 19) and 2.58% (95% CI 2.36-2.80, January 31-February 27). We observed three peaks of age-standardized CFRs paralleling the 6th, 7th and 8th endemic COVID-19 waves driven by Omicron in Japan (2.2% January 31-February 27, 1.0% July 18-August 14 and 1.6% December 26-January 22, 2023, respectively). Population-based CFRs for Omicron variant COVID-19 in Japanese aged ≥70 years remained <3% throughout the period January 2022-March 2023, including during three large endemic waves in this country.

我们评估了 2022 年 1 月至 2023 年 3 月期间在日本 10 个都道府县(1480 万居民)确诊的年龄≥70 岁病例的病死率(CFR),当时奥米克龙变异体在日本占主导地位。我们从遵守《传染病防治法》的公共卫生中心选取了 283,052 名研究对象的病例报告。我们对病例进行了被动随访,直至其隔离期结束、死亡日期或确诊 COVID-19 后 28 天(以先发生者为准)。我们以 2022 年年龄在 70-79 岁、80-89 岁和≥90 岁的日本人口为研究对象,根据 COVID-19 诊断时间分为 16 个亚组,计算了年龄标准化 CFR 及 95% 置信区间 (CI)。总CFR为1.59%(95% CI 1.55-1.64);介于0.67%(95% CI 0.38-0.96,5月23日至6月19日)和2.58%(95% CI 2.36-2.80,1月31日至2月27日)之间。我们观察到年龄标准化 CFR 的三个峰值与日本由 Omicron 驱动的第 6、7 和 8 次 COVID-19 流行波(分别为 2.2%,1 月 31 日-2 月 27 日;1.0%,7 月 18 日-8 月 14 日;1.6%,12 月 26 日-2023 年 1 月 22 日)相平行。年龄≥70 岁的日本人中 Omicron 变体 COVID-19 的基于人口的 CFR 仍为
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引用次数: 0
Genetic diversity and potential transmission of Escherichia albertii in a poultry breeding rural village. 一个家禽养殖农村的白细胞埃希氏菌遗传多样性和潜在传播途径。
IF 1.3 4区 医学 Q4 INFECTIOUS DISEASES Pub Date : 2024-09-30 DOI: 10.7883/yoken.JJID.2024.209
Peihua Zhang, Guodong Yan, Qian Liu, Xi Yang, Jie Zhang, Xi Chen, Hong Wang, Ling Zhang, Xinxia Sui, Xiangning Bai, Yanwen Xiong, Zhengdong Zhang

Escherichia albertii is an emerging foodborne pathogen causing diarrhea. Though various animals, especially poultry, serve as reservoirs, the transmission of E. albertii among reservoirs and the risk to humans remain unclear. This study investigated an E. albertii infected infant with poultry exposure and collected samples from contact persons, poultries, and environment to better understand the transmission dynamics of E. albertii. One E. albertii isolate from contact person, seven isolates from poultries, and six isolates from environment were recovered, respectively. Whole genome sequencing analysis showed that eight strains derived from poultry or environment and classified as ST4633, shared great similarity (cgSNP ≤ 20). However, the patient-derived strain ESA311 had a cgSNP difference of 1165 with human strain ESA339, and differed from poultry and environmental strains (cgSNP range 2417 to 14997), suggesting a distant relatedness. Whole genome phylogeny showed several human-derived E. albertii strains were clustered with those from animal origins. Our results suggested that family-breeding poultry constituted a possible reservoir of E. albertii, with the environment acting as a crucial vector for the spread of these bacteria, posing a risk to humans. Further poultry surveillance is needed to elucidate public health risks associated with E. albertii infection.

白喉杆菌是一种新出现的食源性病原体,可引起腹泻。虽然各种动物(尤其是家禽)都是白喉杆菌的宿主,但白喉杆菌在宿主之间的传播以及对人类的风险仍不清楚。本研究调查了一名因接触家禽而感染白喉杆菌的婴儿,并从接触者、家禽饲养场和环境中采集样本,以更好地了解白喉杆菌的传播动态。研究分别从接触者、家禽饲养场和环境中分离出了 1 株白喉杆菌、7 株和 6 株。全基因组测序分析表明,8 株来自家禽或环境的菌株被归类为 ST4633,它们具有很大的相似性(cgSNP ≤ 20)。然而,患者来源的菌株ESA311与人类菌株ESA339的cgSNP相差1165,与家禽和环境菌株的cgSNP范围(2417至14997)不同,这表明两者之间存在远缘关系。全基因组系统发育显示,一些来自人类的白喉杆菌菌株与来自动物的菌株聚集在一起。我们的研究结果表明,家庭饲养的家禽可能是白喉杆菌的贮藏库,环境是这些细菌传播的重要媒介,对人类构成风险。需要对家禽进行进一步监测,以阐明与白喉杆菌感染相关的公共卫生风险。
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引用次数: 0
Respiratory syncytial virus infection notification trends and interpretation of the reported case data, 2018-2021, Japan. 2018-2021 年日本呼吸道合胞病毒感染通报趋势及病例报告数据解读。
IF 1.3 4区 医学 Q4 INFECTIOUS DISEASES Pub Date : 2024-09-30 DOI: 10.7883/yoken.JJID.2024.187
Miyako Otsuka, Ayu Kasamatsu, Yuzo Arima, Takuri Takahashi, Takeshi Arashiro, Katsuhiro Komase, Reiko Shimbashi, Yuuki Tsuchihashi, Yusuke Kobayashi, Osamu Takahara, Kazuhiko Kanou, Motoi Suzuki

In Japan, as elsewhere, the COVID-19 pandemic affected the notification trends of respiratory syncytial virus (RSV) infection. Here, we describe the epidemiological trends of RSV cases among children reported during 2018-2021 in Japan, based on the national surveillance system. Compared to 2018 and 2019, 2020 saw an unprecedented decrease in RSV notifications per sentinel site. However, 2021 experienced an unseasonably early and high peak in week 28 (peak week in 2018 and 2019: week 37) with a large resurgence in notifications, nationwide and across regions. Regarding age, compared to 2018 and 2019, the number and proportion of cases aged 2, 3, and ≥4-years increased substantially in 2021 but the number of cases aged <1 year decreased slightly. Furthermore, in 2021, the ratio of notifications per site from outpatient clinics to hospitals increased, suggesting a proportionate increase in clinically milder case diagnoses. Notably, RSV-attributed deaths from vital statistics also dropped substantially in 2020 and rebounded in 2021, but were fewer than in 2018 or 2019. While RSV incidence likely declined in 2020 (possibly from COVID-19 countermeasures) and increased in 2021, notifications in 2021 appeared to be associated with milder presentations. Given unpredictable RSV epidemiology, continuous monitoring and pluralistic assessments are imperative.

与其他地方一样,日本的 COVID-19 大流行也影响了呼吸道合胞病毒(RSV)感染的通报趋势。在此,我们根据国家监测系统描述了 2018-2021 年期间日本报告的儿童 RSV 病例的流行病学趋势。与 2018 年和 2019 年相比,2020 年每个哨点的 RSV 报告数量出现了前所未有的下降。然而,2021 年在第 28 周出现了一个反常的早期高峰(2018 年和 2019 年的高峰周:第 37 周),全国和各地区的通报数大幅回升。在年龄方面,与 2018 年和 2019 年相比,2021 年 2 岁、3 岁和≥4 岁病例的数量和比例大幅增加,但年龄在≥4 岁的病例数量和比例则有所下降。
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引用次数: 0
Prediction of prognosis in patients with severe fever with thrombocytopenia syndrome. 预测严重发热伴血小板减少综合征患者的预后。
IF 1.3 4区 医学 Q4 INFECTIOUS DISEASES Pub Date : 2024-09-30 DOI: 10.7883/yoken.JJID.2024.015
Yi Zhang, Lingtong Huang, Zheyue Shu, Wei Wu, Hongliu Cai, Yu Shi

This study aims to understand the clinical characteristics of severe fever with thrombocytopenia syndrome (SFTS) and screen risk factors for the prognosis. This retrospective study collected the epidemiological, demographic, and clinical and laboratory data of 101 patients with SFTS. Patients were divided into survival and deceased groups, and then logistic regression model was used to evaluate the association between predictors and prognostic variables. A joint detection factor model was constructed, and a receiver operating characteristic (ROC) curve was drawn. A nomogram was established using the R language, and its efficiency in the diagnosis of SFTS was evaluated using the Calibrate curve. Patients in the deceased group were more likely to show an elder age, a shorter hospitalization stay, renal failure and multiple organ failure compared with that of the survival group. There were statistical differences in the neutrophil percentage, lymphocyte percentage, neutrophil-to-lymphocyte ratio, platelet (PLT), AST, AST/ALT, blood urea nitrogen, lactate dehydrogenase, hydroxybutyrate dehydrogenase, thromboplastin time and activated partial thromboplastin time between the two groups. Lymphocyte percentage, PLT, and AST/ALT were independent risk factors for mortality in SFTS patients. We established a prediction model for SFTS mortality with good efficiency.

本研究旨在了解严重发热伴血小板减少综合征(SFTS)的临床特征,并筛查预后的危险因素。这项回顾性研究收集了101名严重发热伴血小板减少综合征患者的流行病学、人口统计学、临床和实验室数据。将患者分为存活组和死亡组,然后使用逻辑回归模型评估预测因素与预后变量之间的关联。建立了联合检测因子模型,并绘制了接收者操作特征曲线(ROC)。使用 R 语言建立了一个提名图,并使用校准曲线评估了其在诊断 SFTS 中的效率。与存活组相比,死亡组患者的年龄更大、住院时间更短、肾功能衰竭和多器官功能衰竭的可能性更大。两组患者的中性粒细胞百分比、淋巴细胞百分比、中性粒细胞与淋巴细胞比率、血小板(PLT)、谷草转氨酶、谷草转氨酶/谷丙转氨酶、血尿素氮、乳酸脱氢酶、羟丁酸脱氢酶、凝血活酶时间和活化部分凝血活酶时间存在统计学差异。淋巴细胞百分比、PLT 和 AST/ALT 是 SFTS 患者死亡的独立风险因素。我们建立了一个有效的 SFTS 死亡率预测模型。
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Japanese journal of infectious diseases
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