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Helicobacter pylori vacA allelic combination, dupA, cagE and cagA genotypes and their associations with gastric diseases among Moroccan population. 幽门螺杆菌 vacA 等位基因组合、dupA、cagE 和 cagA 基因型及其与摩洛哥人胃病的关系。
IF 1.3 4区 医学 Q4 INFECTIOUS DISEASES Pub Date : 2024-06-28 DOI: 10.7883/yoken.JJID.2024.061
Souad Oirdi Zahir, Mounia El Khadir, Samia Alaoui Boukhris, Dafr-Allah Benajah, Sidi Adil Ibrahimi, Laila Chbani, Mohamed El Abkari, Bahia Bennani

The combination of the four regions of vacA with cagA, cagE, dupA genes and cagA-EPIYA motifs, was studied to find the most likely combination that can be used as a disease determinant marker in Moroccan population. A total of 838 H. pylori positive obtained from consenting patients, that were previously analyzed by PCR to characterize vacA-s -m, -i regions, cagE status and cagA 3' region polymorphism, were used to characterize vacA-d region and to determine dupA gene status. The analysis shows the predominance of the less virulent combination (vacA(s2m2i2d2)dupA(-)cagE(-)cagA(-)), and shows that the risk of gastric cancer is 13.33 fold higher (1.06-166.37)) in patients infected by strains harboring vacA(s1m1i1d1)dupA(-)cagE(+)cagA(2EPIYA-C) compared to patients with gastritis without lesions and infected by H.pylori strains harboring vacA(s2m2i2d2)dupA(-)cagE(-)cagA(-). The infection with strains harboring vacA(s1m1i1d1)dupA(+)cagE(+)cagA(1EPIYAC) genotype combination represents a risk factor for gastric ulcer and duodenal ulcer (the Odds Ratio (95% CI) were 16 (1.09-234.24) and 6.54 (1.60-26.69) respectively) compared to patients with gastritis without lesions. These results suggest that the combination of the active form of vacA genotypes, dupA gene status and the number of EPIYA-C motif may be considered helpful markers to discriminate between several gastric diseases.

研究人员对 vacA 的四个区域与 cagA、cagE、dupA 基因和 cagA-EPIYA motifs 的组合进行了研究,以找到最有可能用作摩洛哥人群疾病决定性标记的组合。从征得同意的患者身上共获得了 838 例幽门螺杆菌阳性病例,这些病例之前已通过 PCR 分析确定了 vacA-s -m、-i 区域、cagE 状态和 cagA 3' 区域多态性的特征,现在又用来确定 vacA-d 区域的特征和 dupA 基因的状态。分析结果表明,毒力较弱的组合(vacA(s2m2i2d2)dupA(-)cagE(-)cagA(-))占主导地位,并显示胃癌风险在感染了vacA-d区的患者中高出13.33倍(1.06-166.37)),而感染了携带 vacA(s1m1i1d1)dupA(-)cagE(+)cagA(2EPIYA-C) 的幽门螺杆菌菌株的无病变胃炎患者要比感染了携带 vacA(s2m2i2d2)dupA(-)cagE(-)cagA(-) 的幽门螺杆菌菌株的患者高出 13.33 倍。与无病变的胃炎患者相比,感染携带 vacA(s1m1i1d1)dupA(+)cagE(+)cagA(1EPIYAC) 基因型组合的菌株是胃溃疡和十二指肠溃疡的危险因素(Odds Ratio (95% CI) 分别为 16 (1.09-234.24) 和 6.54 (1.60-26.69))。这些结果表明,vacA 基因型的活性形式、dupA 基因状态和 EPIYA-C 矩阵的数量可被认为是区分多种胃病的有用标记物。
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引用次数: 0
Genetic characteristics and phylogenetic analysis of coxsackievirus A6 isolated in Linyi, China, 2022-2023. 2022-2023 年在中国临沂分离的柯萨奇病毒 A6 的遗传特征和系统发育分析。
IF 1.3 4区 医学 Q4 INFECTIOUS DISEASES Pub Date : 2024-06-28 DOI: 10.7883/yoken.JJID.2024.072
Jie Chen, Pengfei You, Xiaoyan Chen, Huafeng Li, Na Zhang, Guangyun Zhang, Conghong Xu, Chunling Ma, Yanli Zhang, Tiegang Lv

Hand, foot and mouth disease (HFMD) was one of the most common infectious disease in the past few decades. After 2013, coxsackievirus A6 (CVA6) has replaced enterovirus 71 (EV-A71) and coxsackievirus A16 (CVA16), becoming the predominant pathogen responsible for HFMD in many areas in China. The objective of this study is to investigate the genetic characteristics and molecular epidemiology of CVA6 in Linyi from 2022 to 2023. A total of 965 HFMD cases were enrolled in this study and analyses based on VP1 nucleotide sequences were performed to determine the evolutionary trajectory of CVA6. In 2022, 281 (281/386, 72.8%) were positive for enterovirus (EVs), and 217 (217/281, 77.2%) were CVA6 positive. In 2023, 398 (398/579, 68.7%) samples were positive for EVs, and 243 (243/398, 61.1%) were CVA6 positive. Six sequences were selected from each year for the homology analysis. The results showed that 12 strains isolated in Linyi were far from the prototype strain (AY421764) and the first CVA6 strain reported in China (JQ364886). Phylogenetic analysis showed that the CVA6 strains isolated in Linyi all belonged to D3 subgenotype. CVA6 is emerging as a common pathogen causing HFMD in Linyi, and continuous surveillance of HFMD etiological agents is necessary.

手足口病(HFMD)是过去几十年中最常见的传染病之一。2013年后,柯萨奇病毒A6(CVA6)取代了肠道病毒71(EV-A71)和柯萨奇病毒A16(CVA16),成为中国许多地区手足口病的主要病原体。本研究旨在调查 2022 年至 2023 年临沂地区 CVA6 的遗传特征和分子流行病学。本研究共纳入 965 例手足口病病例,并基于 VP1 核苷酸序列进行分析,以确定 CVA6 的进化轨迹。2022 年,281 例(281/386,72.8%)肠道病毒 (EV) 阳性,217 例(217/281,77.2%)CVA6 阳性。2023 年,398 个样本(398/579,68.7%)对肠病毒呈阳性,243 个样本(243/398,61.1%)对 CVA6 呈阳性。每年选取 6 个序列进行同源性分析。结果表明,在临沂分离到的 12 株菌株与原型菌株(AY421764)和中国报道的首个 CVA6 菌株(JQ364886)相差甚远。系统进化分析表明,在临沂分离到的 CVA6 株系均属于 D3 亚基因型。CVA6 正在成为引起手足口病的常见病原体,因此有必要对手足口病的病原体进行持续监测。
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引用次数: 0
Distribution and antimicrobial susceptibility pattern of CTX-M-type extended-spectrum β-lactamase-producing Escherichia coli isolated in Chubu region, Japan. 日本中部地区分离到的产 CTX-M 型广谱 β-内酰胺酶大肠杆菌的分布和抗菌药敏感性模式。
IF 1.3 4区 医学 Q4 INFECTIOUS DISEASES Pub Date : 2024-06-28 DOI: 10.7883/yoken.JJID.2024.079
Kazuya Itadani, Yoshimi Oonishi, Harumi Hisada, Tomoaki Tanaka, Shingo Mizunaga, Yuka Yamagishi, Hiroshige Mikamo

The widespread prevalence of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli limits treatment options and is a worldwide problem. The aim of this study was to investigate the antimicrobial susceptibility and ESBL-type of 204 strains of CTX-M-type ESBLs-producing E. coli isolated from 2011 to 2017 in the Chubu region of Japan. Minimal inhibitory concentrations were determined in accordance with the guidelines of the Clinical and Laboratory Standards Institute. Genes encoding CTX-M group β-lactamases were detected by PCR amplification. The CTX-M subtypes were determined using sequence analysis. The CTX-M-9 group was the most frequently detected ESBL group, and CTX-M-27 was the most frequently detected ESBL gene. CTX-M-15-producing strains showed significantly lower rates of susceptibility to tazobactam/piperacillin (TAZ/PIPC) than those by CTX-M-14 and -27-producing strains. Additional analysis of secondary β-lactamases revealed that most of the OXA-1-positive strains were CTX-M-15-producing strains (94.7%). These strains displayed significantly lower susceptibility rates to TAZ/PIPC (47.4%), sulbactam/ampicillin (SBT/ABPC) (0.0%), and amikacin (AMK) (73.7%) than those by OXA-1-negative strains, suggesting that the high non-susceptibility rate of the CTX-M-15-producing strain was due to the co-carriage of OXA-1. The CTX-M-15-producing strains showed reduced susceptibility to TAZ/PIPC, SBT/ABPC, and AMK, presumably due to the co-carriage of OXA-1.

产广谱β-内酰胺酶(ESBL)大肠埃希菌的广泛流行限制了治疗方案,是一个世界性问题。本研究旨在调查2011年至2017年在日本中部地区分离的204株CTX-M型产ESBLs大肠埃希菌的抗菌药敏感性和ESBL类型。最小抑菌浓度是根据临床和实验室标准研究所的指南确定的。通过 PCR 扩增检测了编码 CTX-M 组 β-内酰胺酶的基因。通过序列分析确定了 CTX-M 亚型。CTX-M-9 是最常检测到的 ESBL 组,CTX-M-27 是最常检测到的 ESBL 基因。产生 CTX-M-15 的菌株对他唑巴坦/哌拉西林(TAZ/PIPC)的敏感率明显低于产生 CTX-M-14 和 -27 的菌株。对次级β-内酰胺酶的其他分析表明,大多数 OXA-1 阳性菌株都是 CTX-M-15 产株(94.7%)。这些菌株对 TAZ/PIPC(47.4%)、舒巴坦/氨苄西林(SBT/ABPC)(0.0%)和阿米卡星(AMK)(73.7%)的敏感率明显低于 OXA-1 阴性菌株,表明产 CTX-M-15 菌株的高非敏感率是由于同时携带 OXA-1 所致。产生 CTX-M-15 的菌株对 TAZ/PIPC、SBT/ABPC 和 AMK 的敏感性降低,这可能是由于共携带 OXA-1 的缘故。
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引用次数: 0
A Case of Food Poisoning Caused by Campylobacter jejuni due to Ingestion of Undercooked Chicken Meal with Subsequent Development of Guillain-Barré Syndrome. 一例因摄入未煮熟鸡肉而导致空肠弯曲菌食物中毒并继发格林-巴利综合征的病例
IF 1.3 4区 医学 Q4 INFECTIOUS DISEASES Pub Date : 2024-06-28 DOI: 10.7883/yoken.JJID.2024.108
Satoru Akase, Hiromi Obata, Wakaba Okada, Dai Saiki, Noriko Konishi, Keiko Yokoyama, Kenji Sadamasu

Campylobacter jejuni is one of the major bacteria that causes diarrhea in humans. It has been associated with many cases of food poisoning in Japan caused by eating raw or undercooked chicken meat, chicken liver, and grilled chicken (Yakitori). Campylobacter jejuni is also known as the preceding infection pathogen of Guillain-Barré syndrome (GBS), which causes considerable health impact on humans. In January 2022, in a case of C. jejuni food poisoning that occurred at a restaurant in Tokyo, one of four patients with diarrhea developed GBS. The poisoning is presumed to have been caused by undercooked chicken dishes. Recently, it was one of the common cases in Japan. Moreover, C. jejuni isolates from three patients, including the patient with GBS, had the same genotype (ST22, HS19, and LOS A). This genotype was frequently detected from patients with GBS in our past surveys. Our findings confirmed that the patient developed GBS via food poisoning after consuming undercooked chicken dish.

空肠弯曲菌是导致人类腹泻的主要细菌之一。在日本,许多食物中毒病例都与食用生的或未煮熟的鸡肉、鸡肝和烤鸡肉(烤鸡肉串)有关。空肠弯曲菌也被称为吉兰-巴雷综合征(GBS)的先驱感染病原体,对人类健康造成严重影响。2022 年 1 月,在东京一家餐馆发生的空肠弯曲菌食物中毒事件中,四名腹泻患者中有一人患上了吉-巴氏综合征。据推测,中毒是由未煮熟的鸡肉菜肴引起的。这是日本最近发生的常见病例之一。此外,包括这名 GBS 患者在内的三名患者分离出的空肠大肠杆菌具有相同的基因型(ST22、HS19 和 LOS A)。在我们过去的调查中,GBS 患者中经常检测到这种基因型。我们的研究结果证实,该患者是在食用了未煮熟的鸡肉菜肴后,因食物中毒而患上了 GBS。
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引用次数: 0
Biofilm Eradication and Inhibition of Methicillin-resistant Staphylococcus Clinical Isolates by Curcumin-Chitosan Magnetic Nanoparticles 姜黄素-壳聚糖磁性纳米粒子消除生物膜并抑制耐甲氧西林葡萄球菌临床分离株
IF 2.2 4区 医学 Q2 Medicine Pub Date : 2024-05-31 DOI: 10.7883/yoken.jjid.2024.034
Humberto Antonio Salazar-Sesatty, Edeer Iván Montoya-Hinojosa, Verónica Villarreal-Salazar, Cynthia Aracely Alvizo-Baez, Adrián Camacho-Ortiz, Luis Daniel Terrazas-Armendariz, Itza Eloisa Luna-Cruz, Juan Manuel Alcocer-González, Licet Villarreal-Treviño, Samantha Flores-Treviño

Biofilm-producing methicillin-resistant Staphylococcus aureus (MRSA) and coagulase-negative Staphylococci (MR-CoNS) are a clinical challenge for the treatment of healthcare-associated infections. As alternative antimicrobial options are needed, we aimed to determine the effect of curcumin-chitosan magnetic nanoparticles on the biofilm of staphylococcal clinical isolates. MRSA and CoNS clinical isolates were identified by MALDI-TOF mass spectrometry. Antimicrobial susceptibility testing was performed by broth microdilution. Nanoparticles were synthesized by co-precipitation of magnetic nanoparticles (MNP) and encapsulation by ionotropic gelation of curcumin (Cur) and chitosan (Chi). Biofilm inhibition and eradication by nanoparticles with and without the addition of oxacillin was assessed on staphylococcal strains. Cur-Chi-MNP showed antimicrobial activity on planktonic cells of MRSA and MR-CoNS strains and inhibited biofilm of MRSA. The addition of OXA to Cur-Chi-MNP increased biofilm inhibition and eradication activity against all Staphylococci strains (p=0.0007); higher biofilm activity was observed in early biofilm stages. Cur-Chi-MNP showed antimicrobial and biofilm inhibition activity against S. aureus. The addition of OXA increased biofilm inhibition and eradication activity against all Staphylococci strains. A combination treatment of Cur-Chi-MNP and OXA could be potentially used to treat staphylococcal biofilm-associated infections in its early stages before the establishment of biofilm bacterial cells.

产生生物膜的耐甲氧西林金黄色葡萄球菌(MRSA)和凝固酶阴性葡萄球菌(MR-CoNS)是治疗医疗相关感染的临床难题。由于需要替代抗菌剂,我们旨在确定姜黄素-壳聚糖磁性纳米粒子对葡萄球菌临床分离株生物膜的影响。通过 MALDI-TOF 质谱鉴定了 MRSA 和 CoNS 临床分离物。抗菌药物敏感性测试采用肉汤微量稀释法进行。通过共沉淀磁性纳米粒子(MNP)和姜黄素(Cur)与壳聚糖(Chi)的离子凝胶化来合成纳米粒子。评估了纳米颗粒在添加或不添加氧青霉素的情况下对葡萄球菌菌株生物膜的抑制和消除作用。Cur-Chi-MNP 对 MRSA 和 MR-CoNS 菌株的浮游细胞具有抗菌活性,并能抑制 MRSA 的生物膜。在 Cur-Chi-MNP 中添加 OXA 可提高对所有葡萄球菌菌株的生物膜抑制和根除活性(p=0.0007);在生物膜早期阶段可观察到更高的生物膜活性。Cur-Chi-MNP 对金黄色葡萄球菌具有抗菌和抑制生物膜的活性。添加 OXA 增加了对所有葡萄球菌菌株的生物膜抑制和根除活性。Cur-Chi-MNP 和 OXA 的组合疗法有可能在葡萄球菌生物膜相关感染的早期阶段,即细菌细胞形成生物膜之前,用于治疗这种感染。
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引用次数: 0
Prevalence of human adenovirus type 3 associated with pharyngoconjunctival fever in children in Osaka, Japan during and after the COVID-19 pandemic 在 COVID-19 大流行期间和之后,日本大阪儿童中与咽结膜炎相关的人类腺病毒 3 型的流行率
IF 2.2 4区 医学 Q2 Medicine Pub Date : 2024-05-31 DOI: 10.7883/yoken.jjid.2024.035
Mei Koyama, Satoshi Hiroi, Yuki Hirai, Atsushi Kaida

Since the COVID-19 pandemic has affected the epidemiological pattern of pharyngoconjunctival fever (PCF) caused by human adenovirus (HAdV), the prevalence and type distribution of HAdVs associated with PCF among children in Osaka, Japan, between 2019 and 2023 have been analyzed. The number of reported PCF cases in Osaka decreased from 2020 to 2022, followed by an unprecedented increase in 2023. HAdV-C strains, including types C1, C2, and C5, were annually detected in pathogen surveillance in Osaka. HAdV-B3 was not detected for 2 years and 9 months from March 2020, and the number of detections increased from July 2023. In total, HAdV-B3 was the most frequently detected (27 of 52 strains), and genetic analysis of its hexon hypervariable regions showed that, except for one strain, the HAdV-B3 strains identified after 2022 had different amino acid substitutions compared to those identified in 2019 and 2020. These results suggest that the PCF epidemic in 2023 was predominantly caused by variant strains of HAdV-B3, and children who have not acquired immunity against HAdV-B3 between 2020 and 2022 were thought to be infected. The impact of COVID-19 on the prevalence of HAdV infections needs to be continuously evaluated through surveillance.

由于 COVID-19 大流行影响了由人类腺病毒(HAdV)引起的咽结膜热(PCF)的流行病学模式,因此我们对 2019 年至 2023 年期间日本大阪儿童中与 PCF 相关的 HAdV 的流行率和类型分布进行了分析。大阪报告的 PCF 病例数在 2020 年至 2022 年期间有所减少,但在 2023 年出现了前所未有的增长。在大阪的病原体监测中,每年都能检测到 HAdV-C 株,包括 C1、C2 和 C5 型。自 2020 年 3 月起,HAdV-B3 已有 2 年零 9 个月未被检测到,而自 2023 年 7 月起,检测次数有所增加。总的来说,HAdV-B3 是最常检测到的病毒(52 株中有 27 株),对其 hexon 超变异区的基因分析表明,除一株外,2022 年之后检测到的 HAdV-B3 株与 2019 年和 2020 年检测到的株相比,氨基酸替换不同。这些结果表明,2023年的PCF疫情主要是由HAdV-B3变异株引起的,2020年至2022年期间未获得HAdV-B3免疫力的儿童被认为受到了感染。COVID-19对HAdV感染率的影响需要通过监测进行持续评估。
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引用次数: 0
A descriptive epidemiology in syphilis in Tokyo, 2019-2022 2019-2022 年东京梅毒描述性流行病学
IF 2.2 4区 医学 Q2 Medicine Pub Date : 2024-05-31 DOI: 10.7883/yoken.jjid.2024.012
Yukari Murata, Atsushi Yoshida, Eriko Suzuki, Asamoe Ogawa, Konomi Murauchi, Miyoko Hoshi, Yoshiko Somura, Yoshiyuki Sugishita, Itaru Nishizuka, Kazuhisa Yoshimura

The number of syphilis cases in Tokyo has been found to increase in recent years. We conducted a descriptive epidemiology to elucidate the actual status of syphilis. Data on age, sex, disease stage, and presumed sexual partner of syphilis cases reported in Tokyo were tabulated and analyzed. A total of 9,419 syphilis cases have been reported between 2019 and 2022. There was a particularly sharp rise in the number of reported cases from 2021 to 2022. Comparing 2020 to 2022, the number of syphilis cases among women in their 20s, rapidly increased, more than triple. Furthermore, the number of pregnant women among syphilis cases increased in 2022. Despite the rapid increase in the number of young women with syphilis, there has been no increase in cases of congenital syphilis. One of the reasons may be that syphilis was detected early in pregnancy due to the high antenatal checkup rate in Tokyo. However, the continued incidence of syphilis among young women may increase congenital syphilis in the future. Public health strategy should include educational activities targeting high-risk populations or adolescents, early and appropriate testing, and treatment for preventing progression of syphilis.

近年来,东京的梅毒病例数量呈上升趋势。我们开展了一项描述性流行病学研究,以阐明梅毒的实际状况。我们对东京梅毒病例的年龄、性别、病期和推测性伴侣等数据进行了统计和分析。在2019年至2022年期间,共报告了9419例梅毒病例。2021年至2022年报告的病例数急剧上升。与 2020 年和 2022 年相比,20 多岁女性的梅毒病例数迅速增加了两倍多。此外,2022 年梅毒病例中的孕妇人数也有所增加。尽管年轻女性梅毒患者人数迅速增加,但先天性梅毒病例却没有增加。原因之一可能是由于东京的产前检查率较高,梅毒在怀孕早期就被发现。不过,年轻女性梅毒发病率的持续上升可能会增加先天性梅毒的发病率。公共卫生战略应包括针对高危人群或青少年的教育活动、早期和适当的检测以及预防梅毒恶化的治疗。
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引用次数: 0
Re-emerging, under-recognized zoonotic, and neglected tropical diseases in Hawaiʻi 夏威夷再次出现、认识不足的人畜共患疾病和被忽视的热带疾病
IF 2.2 4区 医学 Q2 Medicine Pub Date : 2024-05-31 DOI: 10.7883/yoken.jjid.2023.476
Rodson Zorilla, Lauren Ching, Tiana Elisara, Kenton Kramer, Vivek Ramchandra Nerurkar

Hawaiʻi, the United States’ most western geographic state in the Pacific, is intermediate between the North and South American continents and Indo-Pacific regions, including Japan. The Hawaiian Islands’ tropical environmental conditions provide favorable ecosystems for various infectious pathogens, their vectors, and reservoirs. This creates a conducive environment for-transmission of various zoonotic diseases that affect both humans and animals. Hawaiʻi has experienced an increase in outbreaks of dengue, leptospirosis, and murine typhus. Further, toxoplasmosis and neuroangiostrongyliasis cases remain prevalent throughout the state, and the putative presence of autochthonous Zika cases in a retrospective study may be of national public health concern. Understanding the factors that affect the transmission and distribution of zoonoses is necessary to identify at-risk places and populations. The One Health approach seeks to understand, report, and interpret these factors and requires collaborations between private and government institutions. One Health should focus its efforts on neglected tropical diseases (NTD) and prioritize intervention development to control and prevent the transmission of diseases that spread between animals and humans. This review will focus on the epidemiological and clinical characteristics of under-recognized zoonotic and NTD affecting Hawaiʻi: leptospirosis, murine typhus, neuroangiostrongyliasis, toxoplasmosis, dengue, and Zika infections.

夏威夷是美国太平洋最西端的地理州,位于南北美洲大陆和印度洋-太平洋地区(包括日本)之间。夏威夷群岛的热带环境条件为各种传染病病原体、病原体载体和病原体库提供了有利的生态系统。这为影响人类和动物的各种人畜共患病的传播创造了有利的环境。夏威夷已经经历了登革热、钩端螺旋体病和鼠型斑疹伤寒爆发的增加。此外,弓形虫病和神经源性弓形虫病病例在全州仍然很普遍,而一项回顾性研究中推测存在的自生寨卡病例可能会引起全国性的公共卫生关注。了解影响人畜共患病传播和分布的因素对于确定高危地区和人群十分必要。一体健康 "方法旨在了解、报告和解释这些因素,需要私人机构和政府机构之间的合作。一体健康 "应将工作重点放在被忽视的热带疾病(NTD)上,并优先制定干预措施,以控制和预防在动物和人类之间传播的疾病。本综述将重点关注夏威夷未得到充分认识的人畜共患疾病和被忽视的热带疾病的流行病学和临床特征:钩端螺旋体病、鼠斑疹伤寒、神经angiostrongyliasis、弓形虫病、登革热和寨卡病毒感染。
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引用次数: 0
Microelimination of Hepatitis C in patients with substance use and dual disorders – a Portuguese study 药物使用和双重失调患者中丙型肝炎的微量消除--葡萄牙的一项研究
IF 2.2 4区 医学 Q2 Medicine Pub Date : 2024-05-31 DOI: 10.7883/yoken.jjid.2024.056
Isabela Faria, Rita Facão, Filipa Murta, Rúben Carvalho, Carla Silva, Ilda Murta, Cristina Valente

Chronic hepatitis C is a serious condition with relevant public health implications. In Portugal, the prevalence of detectable HCV antibodies is about 0,54%, with higher values in risk groups. Compared to the general population, the prevalence of HCV infection is higher in individuals with psychiatric disorders. There are no studies reporting the prevalence of HCV antibodies in Portuguese psychiatric patients, or in patients with substance use disorders.We carried an observational, prospective study during a period of one year, for patients followed at the Dual Pathology Outpatient and Inpatient Unity of the Coimbra Hospital and University Center, and patients were tested for HCV antibodies. Of 149 patients, 17.4% had positive HCV antibodies and 7.38% had detectable HCV RNA. Patients with confirmed CHC were mostly male inpatients, aged 50 to 59 years, and reported unprotected sex with more than one concurrent partner in the previous six months; their main psychiatric diagnosis was “Disorders due to use of multiple specified psychoactive substances, including medications”.This study reports a very high prevalence of positive HCV antibodies and confirmed CHC in patients followed in the Dual Pathology Outpatient and Inpatient Unity. This prevalence is higher than in general Portuguese population.

慢性丙型肝炎是一种严重的疾病,对公众健康具有重要影响。在葡萄牙,可检测到的丙型肝炎病毒(HCV)抗体的流行率约为 0.54%,高危人群的流行率更高。与普通人群相比,精神障碍患者的丙型肝炎病毒感染率更高。我们开展了一项为期一年的前瞻性观察研究,研究对象是科英布拉医院和大学中心双重病理门诊和住院部的患者,并对患者进行了丙型肝炎病毒抗体检测。在149名患者中,17.4%的患者HCV抗体呈阳性,7.38%的患者可检测到HCV RNA。确诊为慢性阻塞性肺病的患者多为男性住院病人,年龄在 50 至 59 岁之间,在过去六个月中曾与一个以上的伴侣发生过无保护措施的性行为;他们的主要精神诊断为 "因使用多种特定精神活性物质(包括药物)而导致的精神障碍"。这一患病率高于葡萄牙一般人群。
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引用次数: 0
Nosocomial outbreak of SARS-CoV-2 in a hospital ward during the Omicron variant-dominant wave with a review of the relevant literature 奥米克龙变异主导潮期间某医院病房爆发的非典型肺炎-CoV-2疫情及相关文献综述
IF 2.2 4区 医学 Q2 Medicine Pub Date : 2024-05-31 DOI: 10.7883/yoken.jjid.2023.464
Hilary Osaka, Yasuaki Tagashira, Hiroaki Takeuchi, Yukie Tanaka, Kousuke Tanimoto, Yoshiaki Gu

Clusters of nosocomial coronavirus disease 2019 (COVID-19) were reported globally during the recent pandemic. Unfortunately, these clusters negatively impacted inpatient morbidity, mortality, and hospital functions. Using epidemiological data and whole genome sequencing (WGS) of SARS-CoV-2, the present study investigated an outbreak of COVID-19 at a university hospital. Eight inpatients and 13 healthcare workers tested positive for SARS-CoV-2 during a one-month period. Whole genome sequencing (WGS) of the virus in 11 patients revealed that two variants of concern belonging to the Omicron sublineages, BA.2.3 and BA1.1.2, had caused the outbreak during a time when the proportion of the Omicron lineage in the community was changing. When variants of concern are undergoing mutation, a response to the outbreak should be made with multiple variants in mind, even in the absence of epidemiological data showing close contact or other potential vectors of infection, and awareness about infection prevention and control should be raised to safeguard patient safety.

在最近的大流行病期间,全球各地都报告了冠状病毒病 2019(COVID-19)集群。不幸的是,这些集群对住院病人的发病率、死亡率和医院功能造成了负面影响。本研究利用流行病学数据和 SARS-CoV-2 的全基因组测序(WGS),对一家大学医院爆发的 COVID-19 进行了调查。在一个月的时间里,8 名住院病人和 13 名医护人员的 SARS-CoV-2 检测结果呈阳性。对 11 名患者的病毒进行的全基因组测序(WGS)显示,属于 Omicron 亚系的两个变种 BA.2.3 和 BA1.1.2 引起了疫情的爆发,而此时 Omicron 亚系在社区中的比例正在发生变化。当令人担忧的变种正在发生变异时,即使没有流行病学数据表明存在密切接触或其他潜在的感染媒介,也应考虑到多种变种,对疫情做出反应,并提高对感染预防和控制的认识,以保障病人的安全。
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Japanese journal of infectious diseases
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