Eosinophilic dermatoses are a heterogeneous group of diseases, characterized by an eosinophil‐rich infiltrate and/or degranulation of eosinophils. Blood eosinophilia may be an associated feature. Typical, albeit not specific histological findings include ‘flame figures’, which are caused by the accumulation of cationic proteins released by eosinophils and subsequent collagen denaturation.
{"title":"Eosinophilic dermatoses","authors":"M. Peckruhn, P. Elsner, J. Tittelbach","doi":"10.1111/ddg.13943","DOIUrl":"https://doi.org/10.1111/ddg.13943","url":null,"abstract":"Eosinophilic dermatoses are a heterogeneous group of diseases, characterized by an eosinophil‐rich infiltrate and/or degranulation of eosinophils. Blood eosinophilia may be an associated feature. Typical, albeit not specific histological findings include ‘flame figures’, which are caused by the accumulation of cationic proteins released by eosinophils and subsequent collagen denaturation.","PeriodicalId":14702,"journal":{"name":"JDDG: Journal der Deutschen Dermatologischen Gesellschaft","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73389373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Kongresskalender 2019","authors":"","doi":"10.1111/ddg.13957","DOIUrl":"https://doi.org/10.1111/ddg.13957","url":null,"abstract":"","PeriodicalId":14702,"journal":{"name":"JDDG: Journal der Deutschen Dermatologischen Gesellschaft","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79477164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Der Einfluss der Primärexzision eines kutanen Plattenepithelkarzinoms auf die Prognose ist abhängig von den Risikofaktoren des Tumors, den chirurgischen Therapiemodalitäten und der histologischen Untersuchung.
雌激素上皮癌的朊病毒毒性对治疗效果的预测的影响取决于肿瘤风险因素、治疗方法和筛查。
{"title":"Lokale chirurgische Therapie des kutanen Plattenepithelkarzinoms: Defizite und Kontroversen in der Literatur","authors":"H. Breuninger, T. Eigentler, H. Häfner, U. Leiter","doi":"10.1111/ddg.13941_g","DOIUrl":"https://doi.org/10.1111/ddg.13941_g","url":null,"abstract":"Der Einfluss der Primärexzision eines kutanen Plattenepithelkarzinoms auf die Prognose ist abhängig von den Risikofaktoren des Tumors, den chirurgischen Therapiemodalitäten und der histologischen Untersuchung.","PeriodicalId":14702,"journal":{"name":"JDDG: Journal der Deutschen Dermatologischen Gesellschaft","volume":"38 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79904911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Nageldystrophie induziert durch systemische Amyloidose","authors":"Gwanghyun Jo, Dong-Yeop Shin, Je‐Ho Mun","doi":"10.1111/ddg.13942_g","DOIUrl":"https://doi.org/10.1111/ddg.13942_g","url":null,"abstract":"","PeriodicalId":14702,"journal":{"name":"JDDG: Journal der Deutschen Dermatologischen Gesellschaft","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89863946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kutane unerwünschte Ereignisse (cutaneous adverse events; CAE) treten bei bis zu 10 % der Patienten mit immunvermittelten entzündlichen Erkrankungen (IMID) auf, die mit Tumornekrosefaktor‐α (TNFα)‐Blockern behandelt werden. Ziel dieser klinischen Studie war es, den Verlauf von CAE bei allen Therapien mit Biologika nachzuverfolgen und zu beobachten.
{"title":"Dermatologische Komplikationen unter Therapie mit Biologika bei entzündlichen Autoimmunerkrankungen","authors":"W. Sondermann, S. Herz, E. Sody, A. Körber","doi":"10.1111/ddg.13964_g","DOIUrl":"https://doi.org/10.1111/ddg.13964_g","url":null,"abstract":"Kutane unerwünschte Ereignisse (cutaneous adverse events; CAE) treten bei bis zu 10 % der Patienten mit immunvermittelten entzündlichen Erkrankungen (IMID) auf, die mit Tumornekrosefaktor‐α (TNFα)‐Blockern behandelt werden. Ziel dieser klinischen Studie war es, den Verlauf von CAE bei allen Therapien mit Biologika nachzuverfolgen und zu beobachten.","PeriodicalId":14702,"journal":{"name":"JDDG: Journal der Deutschen Dermatologischen Gesellschaft","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89063360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Mahler, A. Nast, A. Bauer, D. Becker, J. Brasch, K. Breuer, H. Dickel, H. Drexler, P. Elsner, J. Geier, S. John, B. Kreft, A. Köllner, H. Merk, H. Ott, S. Pleschka, Maria Portisch, P. Spornraft‐Ragaller, E. Weisshaar, T. Werfel, M. Worm, A. Schnuch, W. Uter
Der diagnostische Standard zum Nachweis einer bestehenden allergischen Kontaktdermatitis ist der Epikutantest. Die vorliegende Leitlinie richtet sich an Assistenz‐ und Fachärzte der Dermatologie, Allergologie und Ärzte weiterer Fachgruppen in Klinik und Praxis, die an der Indikationsstellung oder Durchführung von Epikutantests bei Patienten mit Kontaktekzemen und weiteren Spättypallergien beteiligt sind, sowie Kooperationspartner der Ärzteschaft (Fachberufe im Gesundheitswesen, Kostenträger).
{"title":"S3‐Leitlinie: Durchführung des Epikutantests mit Kontaktallergenen und Arzneimitteln – Kurzfassung Teil 1","authors":"V. Mahler, A. Nast, A. Bauer, D. Becker, J. Brasch, K. Breuer, H. Dickel, H. Drexler, P. Elsner, J. Geier, S. John, B. Kreft, A. Köllner, H. Merk, H. Ott, S. Pleschka, Maria Portisch, P. Spornraft‐Ragaller, E. Weisshaar, T. Werfel, M. Worm, A. Schnuch, W. Uter","doi":"10.1111/ddg.13956_g","DOIUrl":"https://doi.org/10.1111/ddg.13956_g","url":null,"abstract":"Der diagnostische Standard zum Nachweis einer bestehenden allergischen Kontaktdermatitis ist der Epikutantest. Die vorliegende Leitlinie richtet sich an Assistenz‐ und Fachärzte der Dermatologie, Allergologie und Ärzte weiterer Fachgruppen in Klinik und Praxis, die an der Indikationsstellung oder Durchführung von Epikutantests bei Patienten mit Kontaktekzemen und weiteren Spättypallergien beteiligt sind, sowie Kooperationspartner der Ärzteschaft (Fachberufe im Gesundheitswesen, Kostenträger).","PeriodicalId":14702,"journal":{"name":"JDDG: Journal der Deutschen Dermatologischen Gesellschaft","volume":"65 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89154545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Monica Corazza, A. Borghi, Roberta Gafà, C. Ghirardi, Stefano Ferretti
{"title":"Vulvakarzinomrisiko bei Frauen mit Lichen sclerosus: Ergebnisse einer Kohortenstudie","authors":"Monica Corazza, A. Borghi, Roberta Gafà, C. Ghirardi, Stefano Ferretti","doi":"10.1111/ddg.13961_g","DOIUrl":"https://doi.org/10.1111/ddg.13961_g","url":null,"abstract":"","PeriodicalId":14702,"journal":{"name":"JDDG: Journal der Deutschen Dermatologischen Gesellschaft","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80255720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aditi Dhanta, Naveen Kumar Kansal, Prashant Durgapal, C. Divyalakshmi
A 16-year-old male presented with multiple lesions involving the lips, shoulder region, extremities and glans penis for the last 1 year. The individual lesions began as small papules that gradually increased to form small, annular, barely palpable plaques. There was no history of oral symptoms or immunosuppression. Cutaneous examination revealed multiple hyperpigmented, annular papules and plaques ranging from 0.5 to 4.0 cm in size with a thready margin over the lips, shoulder region, upper and lower extremities, soles of the feet (Figure 1a, b) and the glans penis. There was no central atrophy. Oromucosal examination revealed an irregular, brownish plaque on the right mucosa with a thready, white, elevated margin. Clinical differential diagnoses of porokeratosis (Mibelli) and annular lichen planus were considered. Dermatoscopy of the lesion on the foot demonstrated a white hyperkeratotic border with dotted vessels and a central area of patchy brownish pigmentation characteristic of porokeratosis (Figure 1c). Biopsies were taken from a lesion on the lower extremity and from oral mucosa for pathologic examination. The cutaneous biopsy showed a hyperkeratotic epidermis with mild lymphocytic exocytosis and spongiosis. A band-like lymphocytic infiltrate was noted in the interphase region and in the papillary dermis along with pigmentary incontinence (Figure 2a, b). The mucosal biopsy showed a dense chronic inflammatory infiltrate along with pigmentary incontinence in the subepithelial zone. Basal cell vacuolation was also noted (Figure 2c). A cornoid lamina was not seen in any of the pathologic sections examined, including further deeper sections and a repeat biopsy. The clinical morphology, dermatoscopic features, and pathology were therefore considered compatible with a diagnosis of porokeratotic lichen planus. Lichen planus is a common papulosquamous inflammatory dermatosis of unknown etiology that presents in a number of morphologic patterns and clinical variants [1–3] and can involve the skin, mucosa and hair as well as the nails [4]. Porokeratosis is a clonal disorder of keratinization that manifests clinically as centrifugally expanding, annular plaque(s) with a ridge-like margin – the cornoid lamella. Cornoid lamella is the diagnostic hallmark, and histology shows a column of tightly packed parakeratotic cells within DOI: 10.1111/ddg.13953 Porokeratotic lichen planus Clinical Letter
{"title":"Porokeratotic lichen planus","authors":"Aditi Dhanta, Naveen Kumar Kansal, Prashant Durgapal, C. Divyalakshmi","doi":"10.1111/ddg.13953","DOIUrl":"https://doi.org/10.1111/ddg.13953","url":null,"abstract":"A 16-year-old male presented with multiple lesions involving the lips, shoulder region, extremities and glans penis for the last 1 year. The individual lesions began as small papules that gradually increased to form small, annular, barely palpable plaques. There was no history of oral symptoms or immunosuppression. Cutaneous examination revealed multiple hyperpigmented, annular papules and plaques ranging from 0.5 to 4.0 cm in size with a thready margin over the lips, shoulder region, upper and lower extremities, soles of the feet (Figure 1a, b) and the glans penis. There was no central atrophy. Oromucosal examination revealed an irregular, brownish plaque on the right mucosa with a thready, white, elevated margin. Clinical differential diagnoses of porokeratosis (Mibelli) and annular lichen planus were considered. Dermatoscopy of the lesion on the foot demonstrated a white hyperkeratotic border with dotted vessels and a central area of patchy brownish pigmentation characteristic of porokeratosis (Figure 1c). Biopsies were taken from a lesion on the lower extremity and from oral mucosa for pathologic examination. The cutaneous biopsy showed a hyperkeratotic epidermis with mild lymphocytic exocytosis and spongiosis. A band-like lymphocytic infiltrate was noted in the interphase region and in the papillary dermis along with pigmentary incontinence (Figure 2a, b). The mucosal biopsy showed a dense chronic inflammatory infiltrate along with pigmentary incontinence in the subepithelial zone. Basal cell vacuolation was also noted (Figure 2c). A cornoid lamina was not seen in any of the pathologic sections examined, including further deeper sections and a repeat biopsy. The clinical morphology, dermatoscopic features, and pathology were therefore considered compatible with a diagnosis of porokeratotic lichen planus. Lichen planus is a common papulosquamous inflammatory dermatosis of unknown etiology that presents in a number of morphologic patterns and clinical variants [1–3] and can involve the skin, mucosa and hair as well as the nails [4]. Porokeratosis is a clonal disorder of keratinization that manifests clinically as centrifugally expanding, annular plaque(s) with a ridge-like margin – the cornoid lamella. Cornoid lamella is the diagnostic hallmark, and histology shows a column of tightly packed parakeratotic cells within DOI: 10.1111/ddg.13953 Porokeratotic lichen planus Clinical Letter","PeriodicalId":14702,"journal":{"name":"JDDG: Journal der Deutschen Dermatologischen Gesellschaft","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73189580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Neues aus der Union of European Medical Specialists (UEMS)","authors":"R. Strohal, U. Längle","doi":"10.1111/ddg.13923_g","DOIUrl":"https://doi.org/10.1111/ddg.13923_g","url":null,"abstract":"","PeriodicalId":14702,"journal":{"name":"JDDG: Journal der Deutschen Dermatologischen Gesellschaft","volume":"209 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73732175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Kutane Plattenepithelkarzinome als Komplikation bei diskoidem Lupus erythematodes","authors":"A. Paschos, P. Lehmann, S. Hofmann","doi":"10.1111/ddg.13944_g","DOIUrl":"https://doi.org/10.1111/ddg.13944_g","url":null,"abstract":"","PeriodicalId":14702,"journal":{"name":"JDDG: Journal der Deutschen Dermatologischen Gesellschaft","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82145866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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