Journal de toxicologie clinique et experimentale最新文献

A 43-year-old man, with no history of cardiac disease, deliberately ingested 4 tablets of a rodenticide containing 12 mg of scilliroside. Vomiting appeared a few minutes later and persisted for 48 hours. At the 20th hour, when he was admitted, EKG revealed a complete atrio-ventricular block which disappeared only on the 4th day. The repolarization abnormalities characteristic of digitalization persisted still further until the 12th day.

Glyceryl thioglycolate has been used for a pair of years in acid permanent wave solutions. It appears to be much more sensitizing than ammonium thioglycolate which is usually the main component of this kind of cosmetics. A case of allergic contact dermatitis due to glyceryl thioglycolate is reported. The patient was a 43-year old woman with an eczematous dermatitis of both hands. She was a hairdresser and eczematous eruptions were strictly work-related. She had no direct contact with most cosmetics and only used tools (scissors, clips, pins, rollers, combs...) and hair spray. Patch testing was however done with the standard patch-test screening tray and all the products used in the shop. The only positive reaction was due to a permanent wave solution containing only glyceryl thioglycolate and glycerol. Positive patch-test reactions were also obtained with hair treated with the permanent wave solution and cut immediately or several weeks after the application of the preparation. This observation shows that glyceryl thioglycolate may be responsible for allergic contact dermatitis in hairdressers; it emphasizes the long remanence of the allergen in the hair that makes its eviction specially difficult.

The authors relate a case of atrioventricular block supplied by junctional rhythm and without blood pressure alteration during a clomipramine poisoning. This electrocardiographic change is unusual and systematic electrocardiography during hospitalization is an absolute necessity.

In many cases, epidemiological studies demonstrate carcinogenic risk of occupational exposures and industrial processes, but do not allow to assess carcinogenic potential of the various substances involved in exposures (speciation). Expert judgment combining human and animal data is needed for classifying and labelling of the pure substances. For decision aiding purpose, a method was established for reviewing critically experimental carcinogenesis: 1. Standardized toxicological profiles are established according to pure substances, species, strains and administration routes. 2. Methodological evaluation is made using a scheme based on 3 critical parameters: study duration which should extend to the life expectancy of the species under study; sample size, the statistical significance of negative experiments being ascertained depending on size of samples; survival rates of groups, since sufficient numbers of animals should be at risk during most of their life span. 3. Classification of the results for risk assessment, taking into account the relevance of the administration routes.

Case report of an exogenous lipoid pneumonitis fortuitously discovered during acute barbituric intoxication. Discussion about pathogenicity of paraffin oil.

Analyses on manganese noxiousness have been carried out various working stations of Moanda. The men who are most exposed work in the grinding and packing posts. In the occupational surroundings we have rates of 146.42 mg/m3 of manganese while in the blood the values turn around 2.310 micrograms/l.

A study was performed in 278 people living in a Mexican town with a high lead environmental pollution. Lead blood level was found very high (m:59.7 micrograms/l) and some abnormalities were also found for free erythrocyte Protoporphyrin and ALA dehydratase. A significant dose-response relationship was also found with somatic complaints like loss of appetite, insomnia and headache.

The determination of airborne contaminants concentration levels at the workplace is presented as an answer to industrial hygiene problems. A step by step logical method is presented, based upon a preliminary survey as wide as achievable, then the sampling step occurs in order to complete the first assessment. Contaminant exposure, identification of pollution sources and effectiveness of engineering controls can be evaluated by air sampling and analysis. Two field experiences are given as examples (lead and styrene exposures).