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Impact of the year of graduation on the positioning of nutrition professionals regarding the vegetarian diet Impacto do ano de formacilo no posicionamento dos profissionais de nutricao face a dieta vegetariana 毕业年份对营养专业人士对素食饮食定位的影响对营养专业人士对素食饮食定位的影响
Pub Date : 2021-03-01 DOI: 10.19277/BBR.18.1.248
Aline Ambrósio, L. Vasconcelos, Marta Raposo, C. Ferreira-Pêgo
The adoption of a vegetarian diet increased over the years. In Portugal, is estimated that 1.2% of the population follows this food pattern. A cross-sectional study was carried out, including a final sample of 74 nutrition professionals to assess their position concerning the vegetarian diet (VD) according to their year of graduation (YG). The results analyses demonstrated that 23 nutrition professionals graduated between 1980 and 2009; and 51 between 2010 and 2019. There were statistically significant differences regarding the possibility of keeping a VD throughout life, since 81.1% of the participants consider it possible, most of them belonging to the group who graduated after 2009. As for supplements, 13% of the nutrition professionals who graduated until 2009 believe it possible to adhere to a VD without resorting to supplements, however, the percentage increases significantly to 39.2% in nutrition professionals trained after 2009. The percentage of nutrition professionals that approved the adherence of athletes to VD increased statistically in recent years, however, most believe this adherence is only possible with the use of supplements. Adherence to VD has increased over the past few years, however, the opinion of nutrition professionals is not unanimous regarding its safety, effectiveness in weight loss, and use of supplementation.
多年来,吃素的人越来越多。在葡萄牙,估计有1.2%的人口遵循这种饮食模式。进行了一项横断面研究,其中包括74名营养专业人员,根据他们的毕业年份评估他们对素食(VD)的立场。结果分析表明,在1980年至2009年期间,有23名营养专业人员毕业;2010年至2019年期间为51人。在一生中保持VD的可能性方面存在统计学上的显著差异,因为81.1%的参与者认为这是可能的,其中大多数属于2009年以后毕业的群体。至于补充剂,在2009年之前毕业的营养专业人员中,有13%的人认为可以在不服用补充剂的情况下坚持VD,然而,在2009年之后接受培训的营养专业人员中,这一比例显著增加到39.2%。近年来,赞同运动员坚持VD的营养专业人员的比例在统计上有所增加,然而,大多数人认为这种坚持只能通过使用补充剂来实现。在过去的几年中,坚持VD的人数有所增加,然而,营养专家对其安全性、减肥效果和补充使用的意见并不一致。
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引用次数: 0
Type 1 medication review based on a pharmacy’s electronic medication records: first steps towards an algorithm to stratify patients for tailored pharmacy services 基于药房电子用药记录的第1类药物审查:为定制药房服务对患者进行分层的算法的第一步
Pub Date : 2021-03-01 DOI: 10.19277/BBR.18.1.251
Lígia Reis, Miguel Monteiro, Luís Lourenço, João Gregório
Algorithms, queries, and knowledge-based systems are among approaches to screen electronic patient records stored in databases and support pharmacist medication reviews. The aim of this study was to perform a type 1 medication review and identify clusters that enable the definition of an algorithm to tailor pharmacy professional interv A retrospective observational study was conducted on a convenience sample of pharmacy records. Records were included if patients had a medication dispensing history between June 2017 - July 2018 and used two or more chronic medications. Statistical analysis used a two-step cluster to identify common characteristics among fifty-five sets of patient records which underwent Type 1 medication review. The median number of drugs used per patient was five [IQR: 3.0 – 7.0]. 18.2% of patients had inappropriate drugs, and 30.9% had moderate or major interaction potential. Four clusters were identified based on the variables of interactions, number of drugs used, contraindications, Beers criteria and measurable biomarkers, allowing to envision possible pharmaceutical interventions, as well as the priority in providing that intervention. The identification of patient clusters via medication review of electronic records of pharmacy patients supports the design of criteria-based algorithms, likely to be automated.
算法、查询和基于知识的系统是筛选存储在数据库中的电子病历和支持药剂师药物审查的方法之一。本研究的目的是进行1类药物回顾,并确定能够定义一种定制药房专业访谈算法的聚类。对药房记录的方便样本进行回顾性观察研究。如果患者在2017年6月至2018年7月期间有药物配药史,并且使用了两种或两种以上的慢性药物,则包括记录。统计分析采用两步聚类来确定55组接受1型药物审查的患者记录的共同特征。每位患者使用药物的中位数为5种[IQR: 3.0 - 7.0]。18.2%的患者存在不适宜用药,30.9%的患者存在中度或重度相互作用潜力。根据相互作用、使用的药物数量、禁忌症、比尔斯标准和可测量的生物标志物等变量确定了四个集群,从而可以设想可能的药物干预措施,以及提供该干预措施的优先级。通过对药房患者电子记录的药物审查来识别患者群,支持基于标准的算法的设计,可能是自动化的。
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引用次数: 0
Topically applied methyl nicotinate evokes a temporary inflammation on human skin 局部应用烟酸甲酯会引起人体皮肤的暂时炎症
Pub Date : 2021-01-01 DOI: 10.19277/bbr.18.1.257
L. Monteiro Rodrigues, Sérgio Faloni de Andrade, Clemente Rocha
Some challengers such as methylnicotinate (MN) have been used in human models to study the anti-inflammatory effect of topical formulations. However, MN skin responses are still poorly understood and widely varied. In the present study we aim to contribute to better characterise those responses. Eight healthy participants were selected. All procedures were approved by the institutional Ethics Committee. Two aqueous MN dilutions (0.5% and 1.0%) were left in contact for 1 minute in the anterior forearm skin. Following exposure, skin reactions were clinically and biometrically assessed at 30, 60 and 120 minutes and compared with baseline. Measurements involved the ICDRG clinical score scale and select analytical technologies - laser Doppler flowmetry, Polarised Spectroscopy, Transepidermal Water Loss Meter, and High Resolution Sonography. Results have shown that MN application evoked a maximal response at 30 minutes with an increase in the ICDRG score between 1-2. Significant changes in TEWL and microcirculation were observed, as was an increased dermal hypoecogenicity (edema), detected by HRS. These effects are compatible with a localised short-duration inflammation and reinforce the interest of MN to be used as a safe and controllable challenger in human models.
一些挑战者,如甲基烟酸(MN)已在人体模型中用于研究局部配方的抗炎作用。然而,人们对MN皮肤反应的了解仍然很少,而且差异很大。在目前的研究中,我们的目标是更好地描述这些反应。选择了8名健康的参与者。所有程序均经机构伦理委员会批准。两种MN水溶液(0.5%和1.0%)在前臂前皮肤接触1分钟。暴露后,在30,60和120分钟对皮肤反应进行临床和生物计量评估,并与基线进行比较。测量涉及ICDRG临床评分量表和选择的分析技术-激光多普勒血流法,极化光谱学,经皮失水仪和高分辨率超声。结果表明,施用MN在30分钟时引起最大反应,ICDRG评分在1-2之间增加。观察到TEWL和微循环的显著变化,以及HRS检测到的皮肤低生理性(水肿)的增加。这些效应与局部短期炎症相容,并增强了MN在人体模型中作为安全可控挑战者的兴趣。
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引用次数: 2
Antioxidant activities and antidiabetic potential of extract of fruits from the Myrtaceae family: inhibitory effects on α-amylase and α-glucosidase activities 桃金桃科果实提取物的抗氧化活性和抗糖尿病潜力:对α-淀粉酶和α-葡萄糖苷酶活性的抑制作用
Pub Date : 2021-01-01 DOI: 10.19277/bbr.18.1.259
Simone Muniz Pacheco, Rejane Giacomelli Tavares, M. Seifert, L. Nora, Rafael de Almeida Schiavon
There is a great diversity of plants which are grown in the Atlantic Forest region of Brazil that produce small, colorful, edible fruit that are used in empiric mode to treat several diseases, such as diabetes, as fruits are a rich source of dietary phenolic antioxidants. In this study, we investigated the inhibitory activity of methanolic fruit extracts from the Myrtaceae family - Psidium cattleianum (araçá), Syzygium cumini (jambolão), Campomanesia xanthocarpa (guabiroba), Eugenia uniflora (pitanga) and Eugenia pyriformis (uvaia) - against α-amylase and intestinal α-glucosidase (maltose and sucrose). The antioxidant activities were evaluated using two different in vitro assays: the 2,2’-azinobis(3-ethylbenzthiazoline-6-sulphonate) (ABTS) test and the 2,2’-diphenyl-1-picrylhydrazyl (DPPH) test. The extracts of P. cattleianum, S. cumini, E. pyriformis inhibited α-amylase activity between 13% and 60% (p<0.05). The extracts of P. cattleianum also inhibited α-glucosidase activity with either maltose or sucrose as substrate between 15% and 61% (p<0.05). Additionally, these fruits are rich in phenolic compounds with antioxidant activities.
巴西大西洋森林地区种植了多种多样的植物,这些植物生产的小而彩色的可食用水果被用于治疗多种疾病,如糖尿病,因为水果是膳食中酚类抗氧化剂的丰富来源。本研究研究了桃金科植物Psidium cattleanum (ara )、Syzygium cumini (jambol)、Campomanesia xanthocarpa (guabiroba)、Eugenia uniflora (pitanga)和Eugenia pyriformis (uvaia)的甲醇果实提取物对α-淀粉酶和肠道α-葡萄糖苷酶(麦芽糖和蔗糖)的抑制活性。采用2种不同的体外抗氧化活性测定法:2,2 ' -氮唑(3-乙基苯并噻唑-6-磺酸盐)(ABTS)试验和2,2 ' -二苯基-1-吡啶肼(DPPH)试验。牛皮草、牛皮草、梨形草提取物对α-淀粉酶活性的抑制作用在13% ~ 60%之间(p<0.05)。麦芽糖和蔗糖对α-葡萄糖苷酶活性的抑制作用在15% ~ 61%之间(p<0.05)。此外,这些水果富含具有抗氧化活性的酚类化合物。
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引用次数: 0
Body composition assessment of vegetarian-vegan and omnivore young women – an exploratory study 素食-素食和杂食年轻女性的身体成分评估-一项探索性研究
Pub Date : 2021-01-01 DOI: 10.19277/bbr.18.1.258
C. Ferreira-Pêgo, Rejane Giacomelli Tavares, Sofia Lopes, Tatiana Fontes, L. Monteiro Rodrigues
Diet is commonly accepted as a determinant of body composition, especially when related to specific lifestyles. Vegetarian-vegan diets, which involve a reduction or elimination of animal product consumption, are believed to be more “healthy,” facilitating weight control and reducing the incidence and clinical course of different diseases, in particular those related to overweight and obesity. Global reviews and metanalysis on these issues, however, are still insufficient. Our preliminary approach addresses the total body composition differences among vegetarians-vegans and omnivorous individuals. This cross-sectional study involved ten healthy women, five vegetarian-vegan, and five omnivores (mean 28.10 years old). Body composition was assessed using a dual-energy x-ray absorptiometry (DXA Lunar Prodigy Advance - General Electric Healthcare®). Other general and sociodemographic variables were also collected by trained dietitians. Our results have shown that the vegetarian-vegan group had a non-significantly lower volume of all types of body mass (total bone, fat, lean, tissue, and fat-free) evaluated. Additionally, the vegetarian-vegan group presented higher values of visceral adipose tissue and subcutaneous adipose tissue (286.20 and 11138.40 cm3, respectively, p > 0.05) compared to the omnivore group. These differences will be further confirmed in subsequent studies.
人们普遍认为饮食是身体组成的决定因素,尤其是与特定的生活方式有关时。素食-纯素饮食涉及减少或消除动物产品的消费,被认为更“健康”,有助于控制体重,减少各种疾病的发病率和临床病程,特别是那些与超重和肥胖有关的疾病。然而,关于这些问题的全球综述和元分析仍然不足。我们的初步方法解决了素食者-素食者和杂食性个体之间的总体组成差异。这项横断面研究涉及10名健康女性,5名素食者和5名杂食者(平均年龄28.10岁)。使用双能x线吸收仪(DXA Lunar Prodigy Advance - General Electric Healthcare®)评估体成分。其他一般和社会人口变量也由训练有素的营养师收集。我们的结果显示,素食-纯素食组在所有类型的体重(总骨骼、脂肪、瘦肉、组织和无脂肪)评估中都没有显著降低。此外,素食-素食组内脏脂肪组织和皮下脂肪组织的数值分别为286.20和11138.40 cm3, p > 0.05)高于杂食组。这些差异将在后续的研究中得到进一步证实。
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引用次数: 2
Hereditary Hemochromatosis (Clinical case) 遗传性血色素沉着症(临床一例)
Pub Date : 2021-01-01 DOI: 10.19277/bbr.18.2.263
Bruno Sousa, Nelson Tavares
A sixty-eight-year-old retired man was sent for Nutrition Consultation by his family doctor due to hereditary hemochromatosis (homozygosity H63D) and other pathologies that require nutritional therapy. He was also sent to a Transfusion Medicine and Rheumatology Consultation. Keywords: hereditary hemochromatosis, excess iron absorption, organ and tissue damage
一位68岁的退休男子因遗传性血色素沉着症(H63D纯合子)和其他病理需要营养治疗,被家庭医生送去营养咨询。他还被送到输血医学和风湿病学会诊。关键词:遗传性血色素沉着症,过量铁吸收,器官和组织损伤
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引用次数: 0
Preliminary safety evaluation of n-butanol from the collagen extraction process and of collagen extract from Oreochromis niloticus (tilapia) skin oriented for dermocosmetics 胶原提取工艺中正丁醇及罗非鱼皮肤胶原提取物的安全性初步评价
Pub Date : 2021-01-01 DOI: 10.19277/bbr.18.1.256
Linda Sánchez-Tuest, Nataly Reátegui-Pinedo, David Salirrosas, Ana Lucía Morocho-Jácome, Fernanda Daud Sarruf, Renata Miliani Martinez, R. Quevedo‐León, Ramiro Fiestas, Carmen Ayala-Jara, André Rolim Baby, Zulita Adriana Prieto
Obtaining new cosmetic ingredients, mainly from sustainable sources, as novel excipients or even active compounds is noteworthy for the cosmetic industry to enhance new innovative dermocosmetics. Thus, it is essential to establish the safety of these new ingredients to avoid adverse events, mainly those associated with clastogenic effects from the chemical compounds used for collagen extraction. In this study, we evaluated solutions of chemical compounds used in the collagen extraction process from tilapia skin (Oreochromis niloticus). The cytotoxic and genotoxic effects of the solutions used in the collagen extraction process were 10.0, 1.0, 0.5, and 0.1% n-butanol. Solutions were evaluated by the Allium test and the comet assay in peripheral white blood cells. The residual water from the final skin wash in the pre-treatment phase and the 0.5% lyophilized collagen extract were also investigated. The absence of cytotoxic and genotoxic activity was demonstrated in the collagen extract, despite the fact that n-butanol showed DNA damage, both in the root cells of Allium cepa and in the white blood cells of human peripheral blood. Therefore, we note the necessity to carry out genotoxicity tests to guarantee the absence of contaminants in the collagen extract for cosmetic purposes
获得新的化妆品成分,主要来自可持续来源,作为新的赋形剂甚至活性化合物是化妆品行业值得注意的,以增强新的创新皮肤化妆品。因此,必须确定这些新成分的安全性,以避免不良事件,主要是与用于胶原蛋白提取的化合物的致裂作用有关的不良事件。在这项研究中,我们评估了罗非鱼皮肤胶原蛋白提取过程中使用的化合物溶液。胶原提取过程中使用的溶液的细胞毒性和基因毒性分别为10.0、1.0、0.5和0.1%正丁醇。通过周围白细胞的Allium试验和comet试验对溶液进行评价。还研究了预处理阶段最后一次洗皮肤的残余水和0.5%冻干胶原蛋白提取物。尽管正丁醇在大蒜根细胞和人外周血白细胞中显示DNA损伤,但胶原提取物中没有细胞毒性和基因毒性活性。因此,我们注意到有必要进行遗传毒性测试,以保证美容用途的胶原蛋白提取物中没有污染物
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引用次数: 1
Studying the impact of different body positioning, squatting, and unipodal flexion on perfusion in the lower limb – an exploratory approach complemented with optical spectroscopy (TiVi) 研究不同体位、下蹲和单足屈曲对下肢灌注的影响——一种探索性方法与光学光谱(TiVi)相结合
Pub Date : 2020-12-01 DOI: 10.19277/BBR.17.2.235
Sergio Nuno, M. Florindo, H. Silva, L. Monteiro Rodrigues
Body posture and movement seem to be responsible for multiple variations of microcirculation in the foot, although difficulties associated with measurement during movement have limited their characterization. This pilot study sought to explore a new non-invasive instrument based on polarized light spectroscopy – the TiVi system, under orthostatic and dynamic conditions. Five healthy participants (duly informed, 26.0 ± 6.5 years of age) of both genders were selected. The protocol involved sequential posture changes (orthostatic variation) and dynamic movements (squatting and unipodal flexion). Perfusion variations were evaluated in both feet by laser-Doppler flowmetry (LDF) and polarized spectroscopy (TiVi). Both systems revealed the same type of modification of these flow-related variables. The most pronounced changes were obtained with exercise, especially with squatting, which caused a marked increase in foot perfusion. Less dramatic but in the same direction, the increased perfusion with unipodal flexion was also observed in the contralateral limb. This study confirmed the interest in using the TiVi system in these domains, as well as the appropriateness of this experimental design to look deeper into the impact of lower limb movement on the functional dynamics of the foot.
身体姿势和运动似乎对足部微循环的多种变化负责,尽管运动过程中测量的困难限制了它们的表征。本初步研究旨在探索一种新的基于偏振光光谱的非侵入性仪器- TiVi系统,在直立和动态条件下。选取健康受试者5名,年龄为26.0±6.5岁,男女均可。该方案包括顺序姿势变化(直立变化)和动态运动(下蹲和单足屈曲)。采用激光多普勒血流法(LDF)和偏振光谱法(TiVi)评估双脚灌注变化。两种系统都揭示了这些与流体相关的变量的相同类型的修改。最明显的变化发生在运动中,尤其是深蹲运动,它会导致足部灌注显著增加。在对侧肢体中也观察到单足屈曲灌注增加,但幅度较小,但方向相同。该研究证实了在这些领域使用TiVi系统的兴趣,以及该实验设计的适当性,以深入研究下肢运动对足部功能动力学的影响。
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引用次数: 2
Editorial - Vol 17: Number 2 社论-第17卷:第2号
Pub Date : 2020-12-01 DOI: 10.19277/bbr.17.2.e
L. Monteiro Rodrigues
A year for balance This was our first year of a new (risky) experience, assuming a totally online edition, new editorial procedures, organization, and layout. Happening in a year definitively marked by the extraordinary global crisis caused by this SARS COVID19 changing the definition of “normality” in all aspects of our life. Biomedical and Biopharmaceutical Research journal is no exception. The year of our full open access was simultaneously, the year of many other changes and impacts. Crisis always give space to opportunities, and we did got ours. BBR journal achieved to be more professional and available. Closer to the authors, to the reviewers and editors interacting in a regular way. Stronger in its processes and therefore more rigorous and transparent, in the right track for consolidation. This is no doubt, the most productive editorial year ever in the history of BBR. Our options were clearly accepted by our authors. We read these outcomes as a trust token that we deeply appreciate. Our success is their success. Therefore, we will continue to do more and better for this instrument of scientific culture specially conceived and reasoned in the common language of our Portuguese speaking communities. We stress our independent character, non-profit defined, exclusively based in the science and education, wholeheartedly dedicated to the growth of scientific culture. This is part of our foundation and our compromise for the future. This 2020 closure number includes two articles in the Nutrition and Food Sciences section, six articles in the Biomedical Sciences section and six others in the Biopharmaceutical Sciences section. Three other documents complete this number – the Proceedings Book of the 55th Annual Congress of the Brazilian Society of Physiology which included the 1st Portuguese-Brazilian Physiology Meeting organized by both countries’ (sister) Physiology Societies, the Proceedings Book from the 2020 CBIOS Science Sessions, and the Proceedings Book from the IV CBIOS Seminar 2020.
这是我们全新(冒险)体验的第一年,假设是一个完全在线的版本,新的编辑程序,组织和布局。这一年的发生无疑标志着这场由SARS - covid - 19引起的非同寻常的全球危机,改变了我们生活各方面“正常”的定义。《生物医学与生物制药研究》杂志也不例外。我们完全开放获取的那一年,同时也是许多其他变化和影响的一年。危机总会给机会让路,我们也抓住了机会。BBR期刊实现了更专业、更普及。更接近作者,更接近审稿人和编辑以一种常规的方式互动。在其程序上更强大,因此更严格和透明,在正确的整合轨道上。毫无疑问,这是BBR历史上最富有成效的编辑年。我们的选择显然被我们的作者所接受。我们将这些结果视为信任的象征,对此我们深表赞赏。我们的成功就是他们的成功。因此,我们将继续为这个科学文化的工具做得更多更好,特别是用我们葡萄牙语社区的共同语言来构思和推理。我们强调我们的独立性,非营利性的定义,专门以科学和教育为基础,竭诚致力于科学文化的成长。这是我们基础的一部分,也是我们对未来的妥协。2020年的关闭号包括营养与食品科学部分的两篇文章,生物医学科学部分的六篇文章和生物制药科学部分的另外六篇文章。其他三份文件完成了这个数字-巴西生理学会第55届年会论文集,其中包括由两国(姐妹)生理学会组织的第一次葡萄牙-巴西生理学会议,2020年CBIOS科学会议的论文集,以及2020年第四届CBIOS研讨会的论文集。
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引用次数: 0
Anthropometric assessment of children aged between 6 and 14 years from a school in Lisbon 里斯本一所学校6至14岁儿童的人体测量学评估
Pub Date : 2020-12-01 DOI: 10.19277/bbr.17.2.237
A. Costa, C. Ferreira-Pêgo, Bruno Sousa
As a global epidemic, obesity is currently a significant public health challenge, especially in children. Childhood obesity is related to short term consequences, but also with an increased risk to develop many comorbidities in adult life, such as cardiovascular diseases, type 2 diabetes, strokes, and others. A cross-sectional study to assess the prevalence of normal weight, pre-obesity and obesity in school-aged children was designed. The final sample size analyzed included 81 participants (47 boys and 34 girls) aged between 6 and 14 years old. Pre-obesity and obesity were determined according to the BMI cut-off points adopted by the IOTF. Although no significant differences were found, the prevalence of pre-obesity and obesity for the total population studied was 16.00% and 6.20%, respectively, with 14.60%, and 4.30% for boys and 17.60% and 8.80% for girls. More girls were pre-obese and obese than boys except at ages 9 and 12. The same age that boys presented cardiometabolic risk associated with a WHtR>0.50. These results emphasize the importance of nutritional status assessment to develop appropriate actions to prevent childhood obesity.
作为一种全球流行病,肥胖目前是一项重大的公共卫生挑战,特别是在儿童中。儿童期肥胖与短期后果有关,但也与成人生活中发生许多合并症的风险增加有关,如心血管疾病、2型糖尿病、中风等。设计了一项横断面研究,以评估学龄儿童正常体重、肥胖前期和肥胖的患病率。最终分析的样本量包括81名参与者(47名男孩和34名女孩),年龄在6至14岁之间。根据IOTF采用的BMI分界点确定肥胖前期和肥胖。虽然没有发现显著差异,但总体研究人群的肥胖前期患病率和肥胖患病率分别为16.00%和6.20%,其中男孩为14.60%和4.30%,女孩为17.60%和8.80%。除9岁和12岁外,女孩的肥胖前期和肥胖程度都高于男孩。同样的年龄,男孩出现心脏代谢风险的WHtR>0.50。这些结果强调了营养状况评估对于制定预防儿童肥胖的适当行动的重要性。
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引用次数: 0
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