{"title":"Cancer associated thrombosis: crosstalk between cancer and blood coagulation-fibrinolysis system","authors":"Seiji MADOIWA","doi":"10.2491/jjsth.34.556","DOIUrl":"https://doi.org/10.2491/jjsth.34.556","url":null,"abstract":"がんに伴う血栓の形成には，腫瘍による圧排や患者の臥床などによる血流の停滞，がん薬物療法やカテーテル留置などによる内皮傷害とともに，がんが増殖し進展する過程で生じる血小板-血液凝固系の活性化や線維素溶解（線溶）系の抑制，免疫機構などが関わる．組織因子はがん化の過程で発現が亢進し，選択的スプライシングによる可溶型組織因子はがんの増殖や血管新生を促進する．がん由来のマイクロパーティクルは，血小板などと膜の融合を介してRNA情報を付与しがんの進展に関与する．がん－フィブリン－血小板凝集塊は，上皮間葉様転換により可塑性と運動性を獲得した循環がん細胞が脆弱性を克服し免疫監視機構から逃れる術であるが，宿主の止血機構に大きな負荷を与える．MET oncogeneはがんの進展と組織因子を関連付けるとともに，がんに合併する播種性血管内凝固の発症に関わる．","PeriodicalId":14803,"journal":{"name":"Japanese Journal of Thrombosis and Hemostasis","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135104995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"4.5-billion-year history of the earth, and disseminated intravascular coagulation","authors":"Satoshi Gando","doi":"10.2491/jjsth.34.590","DOIUrl":"https://doi.org/10.2491/jjsth.34.590","url":null,"abstract":"","PeriodicalId":14803,"journal":{"name":"Japanese Journal of Thrombosis and Hemostasis","volume":"101 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135105010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical internship at UC San Diego Hemophilia and Thrombosis Treatment Center","authors":"Azusa Nagao","doi":"10.2491/jjsth.34.593","DOIUrl":"https://doi.org/10.2491/jjsth.34.593","url":null,"abstract":"","PeriodicalId":14803,"journal":{"name":"Japanese Journal of Thrombosis and Hemostasis","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135104996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Management of cancer-associated thrombosis—current status of treatment of cancer-associated venous thromboembolism—","authors":"Mikio MUKAI","doi":"10.2491/jjsth.34.538","DOIUrl":"https://doi.org/10.2491/jjsth.34.538","url":null,"abstract":"がんと血栓症の関係は古くはトルソー症候群として，そして現在はがん関連血栓症と定義され，両者は密接な関係にあることが知られている．さらに，がん治療において出現する心血管合併症の中で最も発症頻度が高いがん関連静脈血栓症に対する治療は直接経口抗凝固薬の登場により大きく進化しており，各学会において予防と治療を中心とした診療ガイドラインが作成され，最新のアップデートがなされている．その一方で，Onco-Cardiologyのような新しい領域ではがん治療の進歩のスピードに実臨床でのエビデンスの創出が追いついていないため，臨床の現場で鍛えられたエキスパートオピニオンによる臨床実践判断が重要である．そして，抗凝固療法に制限が存在する本邦では「がんと血栓症」対する独自のエビデンスの蓄積とエキスパートオピニオンを生かしたフレキシブルなガイドラインが策定されることが期待される．","PeriodicalId":14803,"journal":{"name":"Japanese Journal of Thrombosis and Hemostasis","volume":"93 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135104994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Journal Club","authors":"","doi":"10.2491/jjsth.34.596","DOIUrl":"https://doi.org/10.2491/jjsth.34.596","url":null,"abstract":"","PeriodicalId":14803,"journal":{"name":"Japanese Journal of Thrombosis and Hemostasis","volume":"100 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135105001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Journal Club","authors":"","doi":"10.2491/jjsth.34.524","DOIUrl":"https://doi.org/10.2491/jjsth.34.524","url":null,"abstract":"","PeriodicalId":14803,"journal":{"name":"Japanese Journal of Thrombosis and Hemostasis","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136258746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Venous thromboembolism (VTE) in gastrointestinal cancer treatment","authors":"Taishi HATA","doi":"10.2491/jjsth.34.584","DOIUrl":"https://doi.org/10.2491/jjsth.34.584","url":null,"abstract":"消化器がん治療におけるvenous thromboembolism（VTE）は大きく，1次予防と治療及び2次予防に分けて考える必要がある．1次予防としては主たる治療である手術時の予防があげられる．欧米においてVTEは循環器疾患の中でも3大致死的血管疾患と認識されており，多くのデータが蓄積されて周術期の予防ガイドラインにも反映されてきた．一方本邦では2004年に初のガイドラインが発刊されたが，内容は海外のデータを参考に日本の現状に合わせたものとして作成され，現在でも内容にはあまり変更はない．しかし血栓形成や出血傾向には人種差もあることから今後は日本人でのデータの蓄積とそれを踏まえたガイドラインの改訂が望まれる．治療及び2次予防において，海外ではがん患者のVTE治療や2次予防薬としてdirect oral anticoagulants（DOAC）がすでに推奨されている．このDOACの登場によってより安全で効果的にがん治療と並行したVTE治療や2次予防ができるようになってきた．","PeriodicalId":14803,"journal":{"name":"Japanese Journal of Thrombosis and Hemostasis","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135105005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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