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Mechanochemical ablation (MOCA) for superficial venous insufficiency: a protocol for a systematic review with meta-analysis. 机械化学消融(MOCA)治疗浅静脉功能不全:一项系统回顾和荟萃分析的方案。
IF 1 Q4 PERIPHERAL VASCULAR DISEASE Pub Date : 2026-02-18 eCollection Date: 2025-01-01 DOI: 10.1590/1677-5449.202301432
Simone Pedroso Jardim, Vinicius Farina Sartori, Iana Kátia Araújo Gonçalves, Carolina Dutra Queiroz Flumignan, Jorge Eduardo de Amorim, Ronald Luiz Gomes Flumignan, Luis Carlos Uta Nakano

Varicose veins are a common disease worldwide, mainly affecting adults, and are estimated to be the 7th most common reason for physician referral in the USA. There is no ideal technique for treatment of varicose veins. Several techniques have emerged in recent years: the most widely used are thermal techniques such as laser and radio frequency and non-thermal techniques such as chemical and mechanochemical ablation (MOCA). MOCA employs a combination of physical damage to the vessel with infusion of a sclerosant fluid with the objective of improving the effects and avoiding disadvantages of thermal ablation such as pain and nerve injuries. The aim of this study will be to evaluate the effects of MOCA for treatment of superficial varicose veins in the lower limbs. We will search randomized controlled trials of MOCA for treatment of varicose veins. The search strategy will include free text terms and controlled vocabulary terms (e.g. Emtree, MeSH) for 'varicose veins', 'varices', 'ablation', 'mechanical ablation', 'chemical ablation', and 'mechanochemical ablation'. We will search at least the following databases: Medline (via Pubmed), Embase, Cochrane Central Register of Controlled Trials, Lilacs, Ibecs, WHO Clinical Trials Platform, and Clinicaltrials.com. The risks of bias will be evaluated with the Cochrane tool. We will report structured summaries of the included studies and conduct meta-analyses if possible. Development of new treatments such as MOCA must be encouraged and validation by systematic reviews is required to demonstrate their effects and support better clinical treatment decisions.

静脉曲张是世界范围内的一种常见疾病,主要影响成年人,估计是美国医生转诊的第7大常见原因。治疗静脉曲张没有理想的方法。近年来出现了几种技术:最广泛使用的是热技术,如激光和射频,以及非热技术,如化学和机械化学烧蚀(MOCA)。MOCA采用物理损伤血管与注入硬化液相结合的方法,目的是改善效果并避免热消融的缺点,如疼痛和神经损伤。本研究的目的是评估MOCA治疗下肢浅静脉曲张的效果。我们将检索MOCA治疗静脉曲张的随机对照试验。搜索策略将包括“静脉曲张”、“静脉曲张”、“消融术”、“机械消融术”、“化学消融术”和“机械化学消融术”的自由文本术语和受控词汇术语(例如Emtree、MeSH)。我们将至少检索以下数据库:Medline(通过Pubmed)、Embase、Cochrane Central Register of Controlled Trials、Lilacs、Ibecs、WHO临床试验平台和Clinicaltrials.com。偏倚风险将通过Cochrane工具进行评估。我们将报告纳入研究的结构化摘要,并在可能的情况下进行meta分析。必须鼓励开发像MOCA这样的新疗法,并且需要通过系统评价来验证它们的效果并支持更好的临床治疗决策。
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引用次数: 0
Effects of the COVID-19 pandemic on thoracic sympathectomies performed on Brazil's Public Health System. COVID-19大流行对巴西公共卫生系统进行胸交感神经切除术的影响
IF 1 Q4 PERIPHERAL VASCULAR DISEASE Pub Date : 2026-02-09 eCollection Date: 2025-01-01 DOI: 10.1590/1677-5449.202401192
Carolina Carvalho Jansen Sorbello, Felipe Soares Oliveira Portela, Marcelo Fiorelli Alexandrino da Silva, Marcelo Passos Teivelis, Giulia de Payrebrune St Séve Marins Girardi, José Ribas Milanez de Campos, Nelson Wolosker

Background: The COVID-19 pandemic affected health resources in Brazil, as priority was given to providing care to those infected. As a result, patients with other pathologies suffered delays in treatment, especially those waiting for elective surgical treatments, such as sympathectomy for hyperhidrosis.

Objectives: To analyze the number of thoracic sympathectomies performed to treat hyperhidrosis on the Brazilian Unified Health System (SUS), their mortality, demographics, length of hospital stay, and associated costs in the periods before, during, and after the peak of the COVID-19 pandemic.

Methods: This is a retrospective cross-sectional study that analyzed the number of video-assisted thoracic sympathectomies performed on the SUS in the 2 years prior to the pandemic (2018 and 2019), the 2 years of peak pandemic (2020 and 2021), and the 2 years after (2022 and 2023). Data on regional distribution, profile of patients, hospitalization, and associated mortality were also analyzed. Figures were extracted from the SUS Department of Informatics (DATASUS) database.

Results: The number of sympathectomies performed in Brazil during 2020 and 2021 was 60% lower than the number recorded in 2018 and 2019, followed by a 30% smaller than expected increase in 2022 and 2023. Half of these procedures were conducted in the Southeast region of the country. The profile of patients was predominantly young women. Hospitalization time, costs, and mortality were stable over the years.

Conclusions: The volume of sympathectomies for treatment of hyperhidrosis in the SUS was severely affected by the COVID-19 pandemic and remains in slow recovery. The regional distribution, demographic profile, hospitalization data, and mortality rate remained stable.

背景:COVID-19大流行影响了巴西的卫生资源,因为为感染者提供护理是优先事项。因此,患有其他病理的患者在治疗上受到延误,特别是那些等待选择性手术治疗的患者,如多汗症的交感神经切除术。目的:分析巴西统一卫生系统(SUS)为治疗多汗症而进行的胸部交感神经切除术的数量、死亡率、人口统计数据、住院时间以及在COVID-19大流行高峰之前、期间和之后的相关费用。方法:这是一项回顾性横断面研究,分析了大流行前2年(2018年和2019年)、大流行高峰期2年(2020年和2021年)和大流行后2年(2022年和2023年)在SUS上进行的视频辅助胸交感神经切除术的数量。还分析了区域分布、患者概况、住院和相关死亡率的数据。数据摘自SUS信息部(DATASUS)数据库。结果:巴西在2020年和2021年进行的交感神经切除术数量比2018年和2019年减少了60%,其次是2022年和2023年的增长比预期减少了30%。这些手术中有一半是在该国东南部地区进行的。患者主要是年轻女性。住院时间、费用和死亡率多年来保持稳定。结论:新冠肺炎疫情对SUS治疗多汗症的交感神经切除量影响较大,恢复缓慢。区域分布、人口概况、住院数据和死亡率保持稳定。
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引用次数: 0
Treatment of penetrating injuries to the retrohepatic inferior vena cava: a systematic review. 肝后下腔静脉穿透伤的治疗:系统回顾。
IF 1 Q4 PERIPHERAL VASCULAR DISEASE Pub Date : 2026-02-06 eCollection Date: 2025-01-01 DOI: 10.1590/1677-5449.202401492
Adenauer Marinho de Oliveira Góes, Simone de Campos Vieira Abib, Gustavo Henrique Dumont Kleinsorge, Daniella Adrea Araujo Rossi Vieira, Luis Carlos Uta Nakano, Mariseth Carvalho de Andrade

Background: Injuries to the retrohepatic vena cava are associated with high mortality rates and vascular control must be obtained prior to exposure. Various treatment techniques have been described, including triple hepatic vascular exclusion, atriocaval shunt, and endovascular and hybrid strategies.

Objectives: To determine which of these is associated with the lowest mortality rate.

Methods: A systematic literature review was conducted, guided by the Cochrane Handbook and PRISMA guidelines. The PUBMED, LILACS, Embase, Web of science, and Scopus databases were searched and Ryyan software was employed to manage the studies identified.

Results: Sixteen studies were selected, reporting 96 cases, in 49 of which the patients were treated with triple hepatic exclusion, in 38 with an atriocaval shunt, and in 9 with endovascular or hybrid techniques, with the third of these groups being statistically less frequent (p < 0.0001). The mortality rate was 53.8%, with no statistically significant differences between any of the techniques studied (p = 0.9085).

Conclusions: Injuries to the retrohepatic vena cava had similar mortality rates regardless of the technique employed for treatment.

背景:肝后腔静脉损伤与高死亡率相关,暴露前必须对血管进行控制。各种治疗技术已被描述,包括三重肝血管排除,房腔分流,血管内和混合策略。目的:确定哪种方法与最低死亡率相关。方法:以Cochrane手册和PRISMA指南为指导,进行系统的文献综述。检索PUBMED、LILACS、Embase、Web of science和Scopus数据库,使用Ryyan软件对确定的研究进行管理。结果:入选16项研究,共报告96例,其中49例采用三联肝排除,38例采用房腔分流术,9例采用血管内或混合技术,其中第三组的发生率较低(p < 0.0001)。死亡率为53.8%,两种方法间差异无统计学意义(p = 0.9085)。结论:无论采用何种治疗方法,肝后腔静脉损伤的死亡率相似。
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引用次数: 0
Strategy and cost analysis of vascular access for hemodialysis in North Macedonia. 北马其顿血液透析血管通路的策略和成本分析。
IF 1 Q4 PERIPHERAL VASCULAR DISEASE Pub Date : 2026-01-12 eCollection Date: 2025-01-01 DOI: 10.1590/1677-5449.202500292
Nikola Gjorgjievski, Vlatko Karanfiovski, Petar Dejanov, Igor Nikolov

Background: Vascular access (VA) is a critical component of hemodialysis (HD). Arteriovenous fistulas (AVFs) are associated with lower morbidity and mortality compared to central venous catheters (CVCs). However, VA practice varies across different healthcare systems.

Objectives: The aim of our study was to evaluate the trends, costs, and distribution of VA types used in North Macedonia over two decades.

Methods: This retrospective study reviewed VA procedures performed at the University Clinic of Nephrology in Skopje from 2002 to 2023, highlighting trends and financial implications. Data on AVFs, tunneled central catheters (TCCs), and temporary catheters were collected and analyzed. Preoperative Doppler ultrasound assessments and follow-up evaluations were used to monitor AVF maturation and CVC placement. The cost analysis was based on the Diagnostic-Related Group coding system.

Results: A total of 25 532 VA procedures were performed, including 5798 AVFs (83% of permanent VA), 1199 TCCs (17%), and 18 535 temporary CVCs. The number of AVFs steadily increased during the whole of the analyzed period, except in 2020 due to the COVID-19 pandemic. Temporary femoral vein catheterization accounted for 90% of CVCs. The financial burden of VA increased from 6.6% of the clinic's budget in 2018 to 9.3% in 2022, with a notable rise in CVC-related expenses.

Conclusions: In North Macedonia, use of temporary CVCs at dialysis initiation remains high. Increasing the number of preemptive AVFs and improving long-term VA planning are essential to optimize patient outcomes and reduce healthcare costs.

背景:血管通路(VA)是血液透析(HD)的关键组成部分。与中心静脉导管(CVCs)相比,动静脉瘘(AVFs)的发病率和死亡率较低。然而,在不同的医疗系统中,VA的实践是不同的。目的:我们研究的目的是评估近二十年来北马其顿使用的VA类型的趋势、成本和分布。方法:这项回顾性研究回顾了2002年至2023年在斯科普里肾内科大学诊所进行的VA手术,突出了趋势和财务影响。收集并分析avf,隧道中心导管(tcc)和临时导管的数据。术前多普勒超声评估和随访评价监测AVF成熟和CVC位置。成本分析基于诊断相关组编码系统。结果:共进行了25532例VA手术,其中avf 5798例(占永久性VA的83%),tcc 1199例(占17%),临时cvc 18535例。在整个分析期间,除2020年因COVID-19大流行外,avf数量稳步增加。临时股静脉置管占cvc的90%。VA的财务负担从2018年占诊所预算的6.6%增加到2022年的9.3%,与cvc相关的费用明显增加。结论:在北马其顿,在透析开始时临时cvc的使用率仍然很高。增加先发制人的avf数量和改进长期的VA计划对于优化患者治疗效果和降低医疗成本至关重要。
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引用次数: 0
Fibromuscular dysplasia of the brachial artery diagnosis by Doppler ultrasound: a case report. 多普勒超声诊断肱动脉纤维肌肉发育不良1例。
IF 1 Q4 PERIPHERAL VASCULAR DISEASE Pub Date : 2026-01-12 eCollection Date: 2025-01-01 DOI: 10.1590/1677-5449.202500142
Mariana Jordão França, Luciana Akemi Takahashi, Graciliano José França

Fibromuscular dysplasia (FMD) is a disease of non-inflammatory vascular origin that occurs in medium-sized arteries. Its cause is still unknown. The disease mostly affects middle-aged Caucasian women and, in most cases, involves the renal artery. Disease involvement in the arteries of the upper and lower limbs is rare. We report a case of fibromuscular dysplasia of the medial layer of the brachial artery in an asymptomatic patient using Doppler Ultrasound.

纤维肌肉发育不良(FMD)是一种发生在中等动脉的非炎性血管起源疾病。其原因尚不清楚。这种疾病主要影响中年高加索妇女,在大多数情况下,累及肾动脉。疾病累及上肢和下肢动脉是罕见的。我们报告一例无症状的肱动脉内侧层纤维肌肉发育不良的患者,使用多普勒超声检查。
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引用次数: 0
Incidence and risk factors for contrast-induced nephropathy after angioplasty: an observational retrospective study. 血管成形术后造影剂肾病的发生率和危险因素:一项观察性回顾性研究。
IF 1 Q4 PERIPHERAL VASCULAR DISEASE Pub Date : 2026-01-09 eCollection Date: 2025-01-01 DOI: 10.1590/1677-5449.202500282
Juliana Peres, Jeferson Freitas Toregeani, Amanda Cristina Pohl, Ana Julia Vendrametto, Luciano de Andrade, André Brusamolin Moro

Background: Contrast-induced nephropathy (CIN) is a complication of iodinated contrast media use that can lead to worsening of renal function, increased morbidity and mortality, and the need for renal replacement therapy.

Objectives: To evaluate the incidence of CIN after angioplasty and identify associated factors, including variations in creatinine, glomerular filtration rate (GFR), contrast volume, procedure time, and comorbidities.

Methods: Retrospective study of 305 patients undergoing angioplasty. Clinical and laboratory variables, including serum creatinine and GFR before and after the procedure, were analyzed. CIN was defined as an absolute increase in creatinine ≥ 0.3 mg/dL or a relative increase ≥ 50% within 48 hours. Logistic regression was applied to identify independent predictors.

Results: The incidence of CIN was 10.5% (n = 32/305). Patients with CIN showed a significant reduction in GFR (pre: 73.79 ± 22.5 vs. post: 34.32 ± 11.8 mL/min; p < 0.0001) and increased creatinine (pre: 1.12 ± 0.3 vs. post: 1.78 ± 0.6 mg/dL; p < 0.001). CIN was associated with stroke (p = 0.014), peripheral arterial occlusive disease (p = 0.007), diabetes mellitus (p = 0.002), chronic kidney disease (p = 0.005), and heart failure (p = 0.004). Multivariate analysis confirmed DM (OR = 2.45; 95% CI: 1.12-4.38; p = 0.022) as the main risk factor.

Conclusions: CIN occurred in 10.5% of patients, with DM, CKD, and HF being the main risk factors. These findings reinforce the importance of monitoring to reduce the impact of CIN and optimize clinical outcomes.

背景:造影剂肾病(CIN)是使用碘造影剂的并发症,可导致肾功能恶化,发病率和死亡率增加,需要肾脏替代治疗。目的:评估血管成形术后CIN的发生率,并确定相关因素,包括肌酐、肾小球滤过率(GFR)、造影剂体积、手术时间和合并症的变化。方法:对305例血管成形术患者进行回顾性研究。分析手术前后血清肌酐和GFR等临床和实验室变量。CIN定义为48小时内肌酐绝对升高≥0.3 mg/dL或相对升高≥50%。采用Logistic回归识别独立预测因子。结果:CIN发生率为10.5% (n = 32/305)。CIN患者GFR显著降低(术前:73.79±22.5 vs后:34.32±11.8 mL/min, p < 0.0001),肌酐升高(术前:1.12±0.3 vs后:1.78±0.6 mg/dL, p < 0.001)。CIN与卒中(p = 0.014)、外周动脉闭塞性疾病(p = 0.007)、糖尿病(p = 0.002)、慢性肾病(p = 0.005)和心力衰竭(p = 0.004)相关。多因素分析证实DM (OR = 2.45; 95% CI: 1.12-4.38; p = 0.022)为主要危险因素。结论:CIN发生率为10.5%,其中DM、CKD和HF为主要危险因素。这些发现加强了监测的重要性,以减少CIN的影响和优化临床结果。
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引用次数: 0
Spontaneous massive hemothorax due to inferior phrenic artery pseudoaneurysm: endovascular treatment approach. 膈下动脉假性动脉瘤所致自发性大量血胸:血管内治疗方法。
IF 1 Q4 PERIPHERAL VASCULAR DISEASE Pub Date : 2026-01-09 eCollection Date: 2025-01-01 DOI: 10.1590/1677-5449.202501272
Resham Singh, Annoushka Daniel, Naveen Kumar

Inferior phrenic artery (IPA) pseudoaneurysms are highly uncommon and result from trauma, pancreatitis, or iatrogenic injury. However, rupture can lead to catastrophic hemothorax. The vessel's deep location and non-specific symptoms make early identification a difficult task. We report a case of a 22-year-old woman who was undergoing antitubercular therapy and presented with the onset of acute dyspnea after a five-month history of wheezing and hemoptysis. Computed tomography angiography revealed a pseudoaneurysm originating from the left IPA and a massive left hemothorax. This pseudoaneurysm sac and the descending branch of the IPA were successfully embolized with a glue: lipiodol mixture, followed by hemothorax evacuation. The patient is asymptomatic at 2-month follow-up. Endovascular embolization minimizes morbidity and enables rapid recovery when anatomy is favorable. This report emphasizes the importance of cross-sectional imaging in the early diagnosis and treatment planning of atypical hemothorax presentations.

膈下动脉假性动脉瘤是非常罕见的,通常由外伤、胰腺炎或医源性损伤引起。然而,破裂会导致灾难性的血胸。血管的深层位置和非特异性症状使得早期识别成为一项困难的任务。我们报告一例22岁的妇女谁正在接受抗结核治疗,并提出了急性呼吸困难的发作后五个月的喘息和咯血的历史。计算机断层血管造影显示一个假性动脉瘤起源于左内膈和大量的左血胸。假性动脉瘤囊和IPA的降支被成功地用胶:脂醇混合物栓塞,然后进行胸血排出。随访2个月,患者无症状。当解剖条件良好时,血管内栓塞可将发病率降至最低,并可快速恢复。本报告强调了横断成像在早期诊断和治疗非典型血胸的重要性。
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引用次数: 0
Expression of plasma levels of matrix metalloproteinases and their inhibitors in patients with abdominal aortic aneurysm. 腹主动脉瘤患者血浆基质金属蛋白酶及其抑制剂的表达。
IF 1 Q4 PERIPHERAL VASCULAR DISEASE Pub Date : 2026-01-09 eCollection Date: 2025-01-01 DOI: 10.1590/1677-5449.202501352
Vanessa Souza Silva Medrado, Domingos Sávio de Oliveira E Silva, Leonardo Alves Santos, Luana Macedo da Silva Nascimento, Rodrigo Mendes, Pedro Pereira Tenório
{"title":"Expression of plasma levels of matrix metalloproteinases and their inhibitors in patients with abdominal aortic aneurysm.","authors":"Vanessa Souza Silva Medrado, Domingos Sávio de Oliveira E Silva, Leonardo Alves Santos, Luana Macedo da Silva Nascimento, Rodrigo Mendes, Pedro Pereira Tenório","doi":"10.1590/1677-5449.202501352","DOIUrl":"https://doi.org/10.1590/1677-5449.202501352","url":null,"abstract":"","PeriodicalId":14814,"journal":{"name":"Jornal Vascular Brasileiro","volume":"24 ","pages":"e20250135"},"PeriodicalIF":1.0,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12974594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147432520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hybrid treatment of penetrating trauma of the thoraco-abdominal aorta with bullet embolism to the popliteal artery - case report. 胸腹主动脉穿透伤合并腘动脉子弹栓塞的综合治疗1例。
IF 1 Q4 PERIPHERAL VASCULAR DISEASE Pub Date : 2026-01-09 eCollection Date: 2025-01-01 DOI: 10.1590/1677-5449.202500962
Thiago Filomena Lombard, Luisa Silveira Birck

Bullet embolism is a rare complication of gunshot wounds, but its incidence has increased due to the increasing number of wounds caused by low-velocity firearms in civilian settings. The increase in urban violence and widespread use of firearms with low-velocity projectiles have made diagnosis of ballistic embolism more common, so it is essential to recognize the risk factors for such events. Both treatment of the entry wound and removal of the ballistic embolism can be successfully performed by open, endovascular, or hybrid surgery, and the particularities of each case should be considered. We report the case of a 16-year-old male patient who presented with penetrating aortic trauma in addition to an intra-arterial firearm projectile in the right popliteal artery and underwent hybrid surgery to treat his injuries.

子弹栓塞是枪伤的一种罕见并发症,但由于在民用环境中低速火器造成的伤口越来越多,其发病率也在增加。城市暴力事件的增加和低速弹丸火器的广泛使用使得弹道栓塞的诊断更加普遍,因此认识到此类事件的危险因素至关重要。无论是对射入伤口的治疗还是弹道栓塞的清除,都可以通过开放手术、血管内手术或混合手术来成功完成,并且应该考虑每个病例的特殊性。我们报告一例16岁的男性患者,他表现为穿透性主动脉创伤以及右腘动脉动脉内火器弹丸,并接受混合手术治疗他的损伤。
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引用次数: 0
Digital marketing in attracting new patients: cross-sectional study in a vascular surgery office. 数字营销在吸引新患者中的作用:血管外科办公室的横断面研究。
IF 1 Q4 PERIPHERAL VASCULAR DISEASE Pub Date : 2025-12-15 eCollection Date: 2025-01-01 DOI: 10.1590/1677-5449.202500422
Alex Lazzari Dornelles, Fabricio Rodrigues Santiago, Graciela Aparecida Pelegrini, Camila Biedler Giordani, Thais Muraro Simionato, Silvana Klaki Ternopilski, Mariana Mello

Background: Over the years and the evolution of technology, social networks have become widely accessible and play an important role in interpersonal relationships. Currently, the use of these platforms to disseminate health information ranging from diagnosis to treatments and medical procedures is increasing. In this sense, this study aimed to verify the importance of using social networks in attracting new patients to the office.

Objectives: This study aimed to verify the impact of using social networks on attracting new patients in a medical office of angiology and vascular surgery.

Methods: The study was carried out in a private vascular surgery office, with a sample of 604 patients. Data was collected from January 2022 to December 2023 through an electronic registration, filled out by the secretary at the office.

Results: From the total of 604 patients, 77% were female and 23% male. Of the total number of patients, 41% found out about the office through advertisements made on social media. This generated a positive impact of 38% on the practice's revenue in the period analyzed.

Conclusions: Analysis of the results indicated that the office's presence on social media contributed positively to attracting new patients, as well as increasing revenue. Digital marketing is a trend that will only grow with the spread of the internet and including social networks in the dissemination of health information generates benefits for both parties: doctor and patient.

背景:多年来,随着技术的发展,社交网络已经变得广泛可用,并在人际关系中发挥着重要作用。目前,越来越多地利用这些平台传播从诊断到治疗和医疗程序的卫生信息。从这个意义上说,本研究旨在验证使用社交网络在吸引新患者到办公室的重要性。目的:本研究旨在验证社交网络对血管内科及血管外科吸引新患者的影响。方法:本研究在某民营血管外科办公室进行,样本604例。数据从2022年1月到2023年12月通过电子登记收集,由秘书在办公室填写。结果:604例患者中女性占77%,男性占23%。在所有患者中,41%是通过社交媒体上的广告了解到这家诊所的。在分析期间,这对该业务的收入产生了38%的积极影响。结论:对结果的分析表明,该办公室在社交媒体上的存在对吸引新患者和增加收入有积极的贡献。数字营销是一种趋势,只会随着互联网的普及而发展,包括社交网络在内的健康信息传播对双方都有好处:医生和病人。
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引用次数: 0
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Jornal Vascular Brasileiro
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