F. Iori, P. Ciammella, S. Cozzi, V. Trojani, D. Finocchiaro, C. Iotti
{"title":"Lattice Radiation Therapy: a promising option in metastatic cold tumors, with a bulky primary lesion","authors":"F. Iori, P. Ciammella, S. Cozzi, V. Trojani, D. Finocchiaro, C. Iotti","doi":"10.48286/aro.2022.51","DOIUrl":"https://doi.org/10.48286/aro.2022.51","url":null,"abstract":"","PeriodicalId":148778,"journal":{"name":"Annals of Research in Oncology","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114151459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pediatric cancer and the environment: a fifty-year perspective","authors":"P. Landrigan, P. Landrigan","doi":"10.48286/aro.2022.46","DOIUrl":"https://doi.org/10.48286/aro.2022.46","url":null,"abstract":"","PeriodicalId":148778,"journal":{"name":"Annals of Research in Oncology","volume":"82 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122621681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Homologous Recombination Deficiency (HRD) was initially described in cancers with germline muta-tions of BRCA1 and BRCA2 and thereafter in both sporadic and hereditary cancers carrying muta-tions or epigenetic inactivation of other genes in-volved in HR. Since cancers harbouring HRD are particularly susceptible to PARP inhibitors (PARPi), identifying methods to detect HRD that can accu-rately predict clinical sensitivity to PARPi beyond BRCA1/2 mutations has been challenging. In this review, we describe the HRD biomarkers identified up to now, pointing out strengths and weakness-es of each associated assay.
{"title":"Biomarkers of Homologous Recombination Deficiency in the era of PARP inhibitors","authors":"C. Piombino, L. Cortesi","doi":"10.48286/aro.2022.48","DOIUrl":"https://doi.org/10.48286/aro.2022.48","url":null,"abstract":"Homologous Recombination Deficiency (HRD) was initially described in cancers with germline muta-tions of BRCA1 and BRCA2 and thereafter in both sporadic and hereditary cancers carrying muta-tions or epigenetic inactivation of other genes in-volved in HR. Since cancers harbouring HRD are particularly susceptible to PARP inhibitors (PARPi), identifying methods to detect HRD that can accu-rately predict clinical sensitivity to PARPi beyond BRCA1/2 mutations has been challenging. In this review, we describe the HRD biomarkers identified up to now, pointing out strengths and weakness-es of each associated assay.","PeriodicalId":148778,"journal":{"name":"Annals of Research in Oncology","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132173745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Cimmino, P. Cianciullo, V. Maresca, S. Saggiomo, S. Sorbo, P. Bontempo, A. Basile
Feijoa sellowiana O. Berg is a tropical plant with edible fruits and characterised by a high content of flavonoids. Several studies have shown that Feijoa contains many bioactive components such as flavonoids, vitamin C, and essential minerals that contribute to multiple health benefits, such as antimicrobial, anti-inflammatory, antioxidant, and anticancer activities. Regarding anticancer activity, several authors have shown that the Feijoa fruit acetonic extract and the molecules isolated by it have a selective cytotoxic effect, induce apoptosis, modulate cell cycle against solid and hematologic tumours and are effective against sensitive and re-sistant cancer cells. This review summarizes Feijoa fruit biological activities that
Feijoa sellowiana O. Berg是一种热带植物，果实可食用，其特点是类黄酮含量高。几项研究表明，Feijoa含有许多生物活性成分，如类黄酮、维生素C和必需矿物质，对多种健康有益，如抗菌、抗炎、抗氧化和抗癌活性。在抗癌活性方面，有研究表明，菲荷果丙酮提取物及其分离的分子具有选择性的细胞毒作用，诱导细胞凋亡，调节细胞周期，对实体肿瘤和血液肿瘤有效，对敏感和耐药的癌细胞有效。本文综述了飞荷果的生物活性
{"title":"Feijoa Sellowiana fruit, an amazing source of anticancer molecules","authors":"F. Cimmino, P. Cianciullo, V. Maresca, S. Saggiomo, S. Sorbo, P. Bontempo, A. Basile","doi":"10.48286/aro.2022.44","DOIUrl":"https://doi.org/10.48286/aro.2022.44","url":null,"abstract":"Feijoa sellowiana O. Berg is a tropical plant with edible fruits and characterised by a high content of flavonoids. Several studies have shown that Feijoa contains many bioactive components such as flavonoids, vitamin C, and essential minerals that contribute to multiple health benefits, such as antimicrobial, anti-inflammatory, antioxidant, and anticancer activities. Regarding anticancer activity, several authors have shown that the Feijoa fruit acetonic extract and the molecules isolated by it have a selective cytotoxic effect, induce apoptosis, modulate cell cycle against solid and hematologic tumours and are effective against sensitive and re-sistant cancer cells. This review summarizes Feijoa fruit biological activities that","PeriodicalId":148778,"journal":{"name":"Annals of Research in Oncology","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121235028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Breast cancer (BC) is one of the most prevalent cancer types among women, and among the top for cancer deaths. Research to address this worldwide issue has been conducted to identify risk factors associated with development and treatment. It was identified that risk factors not only includ-ed age, other underlying diseases, environmental factors, but also socioeconomic factors, language barriers and ethnic background. Unfortunately, due to low socioeconomic status groups that are affected the most in the United States are African American and Hispanic women while in Western Europe, such as in Italy, discrimination was based on geographical location rather than racial background. Previous studies indicate that discrimination and racial disparities are relevant factors affecting women battling against breast cancer. By analyzing and highlighting the pitfalls of the current medical approaches to treatment among various ethnic groups in North America and Western Europe, researchers and medical professionals will be better able to tailor treatments and improve prognosis among all BC patients, regardless of race and ethnicity.
{"title":"A review: incidence of breast cancer in ethnic minority groups in north America and populations in western Europe","authors":"S. Burk, A. Giordano","doi":"10.48286/aro.2022.45","DOIUrl":"https://doi.org/10.48286/aro.2022.45","url":null,"abstract":"Breast cancer (BC) is one of the most prevalent cancer types among women, and among the top for cancer deaths. Research to address this worldwide issue has been conducted to identify risk factors associated with development and treatment. It was identified that risk factors not only includ-ed age, other underlying diseases, environmental factors, but also socioeconomic factors, language barriers and ethnic background. Unfortunately, due to low socioeconomic status groups that are affected the most in the United States are African American and Hispanic women while in Western Europe, such as in Italy, discrimination was based on geographical location rather than racial background. Previous studies indicate that discrimination and racial disparities are relevant factors affecting women battling against breast cancer. By analyzing and highlighting the pitfalls of the current medical approaches to treatment among various ethnic groups in North America and Western Europe, researchers and medical professionals will be better able to tailor treatments and improve prognosis among all BC patients, regardless of race and ethnicity.","PeriodicalId":148778,"journal":{"name":"Annals of Research in Oncology","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133758132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Aimola, D. Fanni, C. Gerosa, G. Cerrone, P. Ziranu, A. Pretta, R. Murru, M. Piras, F. Cau, L. Zorcolo, G. La Nasa, M. Castagnola, M. Scartozzi, G. Faa
CDX2 (Caudal-type homeobox transcription factor 2) is a biomarker of differentiated colon enterocytes, whose expression has been associated with a favora-ble prognosis in colon cancer. The absence of CDX2 has been associated with an
{"title":"Balance between the stem cell marker CD44 and CDX2 expression in colorectal cancer","authors":"V. Aimola, D. Fanni, C. Gerosa, G. Cerrone, P. Ziranu, A. Pretta, R. Murru, M. Piras, F. Cau, L. Zorcolo, G. La Nasa, M. Castagnola, M. Scartozzi, G. Faa","doi":"10.48286/aro.2022.43","DOIUrl":"https://doi.org/10.48286/aro.2022.43","url":null,"abstract":"CDX2 (Caudal-type homeobox transcription factor 2) is a biomarker of differentiated colon enterocytes, whose expression has been associated with a favora-ble prognosis in colon cancer. The absence of CDX2 has been associated with an","PeriodicalId":148778,"journal":{"name":"Annals of Research in Oncology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128655659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. De Vita, G. Greco, E. Sperti, C. Zichi, A. Caglio, T. Gamba, J. Paparo, F. Salerno, G. Lacidogna, R. Dionisio, D. Marino, F. Vignani, P. Spanu, A. Bellezza, L. Fusco, L. Polimeno, V. Ariu, S. Terzolo, F. Perrone, L. Di Maio
Received: Apr 26, 2022 Accepted: May 5, 2022 Published: June 8, 2022 F. De Vita1*, G. Greco1*, E. Sperti2, C. Zichi2, A. Caglio1, T. Gamba1, J. Paparo1, F. Salerno1, R. Dionisio2, G. Lacidogna2, D. Marino2, F. Vignani2, P. G. Spanu3, A. Bellezza2, L. Fusco2, L. Polimeno2, V. Ariu2, S. Terzolo2, F. Perrone4, M. Di Maio1 PATIENT-REPORTED FINANCIAL TOXICITY WITHIN THE ITALIAN PUBLIC HEALTHCARE SYSTEM: A SINGLE CENTER CROSS-SECTIONAL ANALYSIS IN PATIENTS WITH CANCER Annals of Research in Oncology Vol. 2(2), 94-104, 2022
{"title":"Patient-reported financial toxicity within the Italian public healthcare system: a single center cross-sectional analysis in patients with cancer","authors":"F. De Vita, G. Greco, E. Sperti, C. Zichi, A. Caglio, T. Gamba, J. Paparo, F. Salerno, G. Lacidogna, R. Dionisio, D. Marino, F. Vignani, P. Spanu, A. Bellezza, L. Fusco, L. Polimeno, V. Ariu, S. Terzolo, F. Perrone, L. Di Maio","doi":"10.48286/aro.2022.42","DOIUrl":"https://doi.org/10.48286/aro.2022.42","url":null,"abstract":"Received: Apr 26, 2022 Accepted: May 5, 2022 Published: June 8, 2022 F. De Vita1*, G. Greco1*, E. Sperti2, C. Zichi2, A. Caglio1, T. Gamba1, J. Paparo1, F. Salerno1, R. Dionisio2, G. Lacidogna2, D. Marino2, F. Vignani2, P. G. Spanu3, A. Bellezza2, L. Fusco2, L. Polimeno2, V. Ariu2, S. Terzolo2, F. Perrone4, M. Di Maio1 PATIENT-REPORTED FINANCIAL TOXICITY WITHIN THE ITALIAN PUBLIC HEALTHCARE SYSTEM: A SINGLE CENTER CROSS-SECTIONAL ANALYSIS IN PATIENTS WITH CANCER Annals of Research in Oncology Vol. 2(2), 94-104, 2022","PeriodicalId":148778,"journal":{"name":"Annals of Research in Oncology","volume":"73 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117295972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Dulcamare, S. Giallongo, N. Vicario, G. Scandura, A. Barbato, E. La Spina, L. Longhitano, D. Cambria, D. Tibullo, T. Zuppelli, D. Lo Furno, R. Parenti, G. Li Volti, G. Palumbo, F. Di Raimondo, A. Romano, C. Giallongo
Multiple myeloma (MM) is a hematological disease characterized by the uncontrolled proliferation of bone marrow malignant plasma cells. Localization and survival of malignant cells relies on bone marrow niche, in turn determined by the interaction between MM cells and mesenchymal stromal cells (MSCs)
{"title":"Hedgehog signaling pathways in multiple myeloma","authors":"I. Dulcamare, S. Giallongo, N. Vicario, G. Scandura, A. Barbato, E. La Spina, L. Longhitano, D. Cambria, D. Tibullo, T. Zuppelli, D. Lo Furno, R. Parenti, G. Li Volti, G. Palumbo, F. Di Raimondo, A. Romano, C. Giallongo","doi":"10.48286/aro.2022.47","DOIUrl":"https://doi.org/10.48286/aro.2022.47","url":null,"abstract":"Multiple myeloma (MM) is a hematological disease characterized by the uncontrolled proliferation of bone marrow malignant plasma cells. Localization and survival of malignant cells relies on bone marrow niche, in turn determined by the interaction between MM cells and mesenchymal stromal cells (MSCs)","PeriodicalId":148778,"journal":{"name":"Annals of Research in Oncology","volume":"131 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116036064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The incidence of cancer at the time of Covid in northern Italy","authors":"L. Mangone, F. Marinelli, I. Bisceglia, C. Pinto","doi":"10.48286/aro.2022.41","DOIUrl":"https://doi.org/10.48286/aro.2022.41","url":null,"abstract":"","PeriodicalId":148778,"journal":{"name":"Annals of Research in Oncology","volume":"113 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122554283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Namagerdi, F. Ciani, D. d’Angelo , F. Napolitano ,, L. Avallone, F. Napolitano, L. Avallone
{"title":"COVID19, ENVIRONMENT, CLINICOPATHOLOGIC FEATURES, LABORATORY FINDINGS AND DIAGNOSIS, TREATMENT, VACCINES, ANIMALS, AND CANCER","authors":"A. Namagerdi, F. Ciani, D. d’Angelo , F. Napolitano ,, L. Avallone, F. Napolitano, L. Avallone","doi":"10.48286/aro.2022.40","DOIUrl":"https://doi.org/10.48286/aro.2022.40","url":null,"abstract":"","PeriodicalId":148778,"journal":{"name":"Annals of Research in Oncology","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127697695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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