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Reductions in Muscle Strength and Range of Motion Cause Locomotion Disability via Locomotion-Related Functional Limitation in Japanese Older Adults: A Cross-Sectional Study. 日本老年人肌肉力量和运动范围的减少通过运动相关功能限制导致运动障碍:一项横断面研究。
IF 4.7 Q4 GERIATRICS & GERONTOLOGY Pub Date : 2021-07-07 eCollection Date: 2021-01-01 DOI: 10.1155/2021/6627767
Hungu Jung, Shigeharu Tanaka, Yuji Iwamoto, Takashi Kawano, Masahiro Yamasaki, Ryo Tanaka

Background: Functional issues (impairments, functional limitations, and disabilities) gradually occur with age. Nonetheless, maintaining physical capability may help prevent locomotion disabilities at an older age. The present study aimed to determine whether reductions in muscle strength and range of motion (ROM) cause locomotion disability via locomotion-related functional limitations among healthy older adults.

Methods: Data from a total of 144 participants (61 men, 83 women) were analyzed. To assess locomotion disability, the locomotor domain of the activities of daily living (ADLs) survey from the Ministry of Education, Culture, Sports, Science, and Technology of Japan was used. Muscle strength (grip strength) and two ROMs (hip flexion and knee flexion) were measured. To measure locomotion-related functional limitations, participants underwent a 10 m hurdle walking test and side-step test. Thereafter, path analysis was conducted for testing the hypothetical model. The goodness of fit in the model was assessed using statistical parameters, such as the chi-square value, goodness of fit index (GFI), adjusted goodness of fit index (AGFI), comparative fit index (CFI), and root mean square error of approximation (RMSEA).

Results: The analysis revealed a nonsignificant chi-square value (chi-square = 41.885; p=0.113), as well as high values of GFI (0.944), AGFI (0.904), CFI (0.970), and RMSEA (0.046), indicating that locomotion disability was caused by locomotion-related functional limitations, which were influenced by muscle strength and ROM.

Conclusions: The present study demonstrated that decreased muscle strength and ROM caused locomotion disability via locomotion-related functional limitations. Older adults should participate in physical exercise programs that focus on strengthening muscles and improving ROM to counteract age-related locomotion disability.

背景:功能问题(损伤、功能限制和残疾)随着年龄的增长而逐渐发生。尽管如此,保持身体机能可能有助于预防老年运动障碍。本研究旨在确定肌肉力量和活动范围(ROM)的减少是否会通过运动相关功能限制导致健康老年人的运动障碍。方法:对144名参与者(61名男性,83名女性)的数据进行分析。为了评估运动障碍,使用了日本文部科学省的日常生活活动(ADLs)的运动域调查。测量肌肉力量(握力)和两个ROMs(髋关节屈曲和膝关节屈曲)。为了测量运动相关的功能限制,参与者进行了10米跨栏行走测试和侧步测试。然后,通过通径分析对假设模型进行检验。采用卡方值、拟合优度指数(GFI)、调整拟合优度指数(AGFI)、比较拟合指数(CFI)、近似均方根误差(RMSEA)等统计参数评价模型的拟合优度。结果:分析显示卡方值无统计学意义(卡方= 41.885;p=0.113), GFI(0.944)、AGFI(0.904)、CFI(0.970)、RMSEA(0.046)均较高,说明运动功能受限是由运动相关功能受限引起的,运动相关功能受限受肌力和ROM的影响。结论:本研究表明肌力和ROM的降低是通过运动相关功能受限引起运动障碍的。老年人应该参加体育锻炼计划,重点是加强肌肉和改善ROM,以抵消与年龄相关的运动障碍。
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引用次数: 5
Aged Persons Living with HIV and Nutritional Wellness: Analysis of 2013 South Africa-SAGE Well-Being of Older People Study (WOPS) Wave 2. 感染艾滋病毒的老年人与营养健康:2013年南非-SAGE老年人福祉研究(WOPS)第2波分析》(Analysis of 2013 South Africa-SAGE Well-Being of Older People Study (WOPS) Wave 2.
IF 1.6 Q4 GERIATRICS & GERONTOLOGY Pub Date : 2021-06-23 eCollection Date: 2021-01-01 DOI: 10.1155/2021/6635814
Joseph Kojo Oduro, Kwaku Kissah-Korsah

Introduction: This study sought to examine the nutritional wellness among aged persons living with HIV in Somkhele, South Africa.

Methods: Data were extracted from the 2013 South Africa-SAGE Well-Being of Older People Study (WOPS) Wave 2. The study sampled 440 aged persons (50 years and above). The proportion of the aged persons with high nutritional wellness by key covariates was reported with chi-square and p-values (p < 0.05). Two-level binary logistic regression models were fitted.

Results: Results show that there were more aged women (79.8%) than men (20.2%) and the younger old (50-64) dominated (65.7%) in the ages, among the respondents. A higher percent of the aged persons were widows (39.5%) and had no formal education (46.1%). Six in 10 aged persons were HIV infected (59.5%). Percentage distribution of men with high nutrition was higher (78.7%). Regression results show that having nutritional wellness was low for aged persons who were infected by HIV (OR = 0.74, 95% CI = 0.69, 1.26) when compared to those who were not infected. Regarding ages of respondents, having high nutritional wellness was higher for young old (65-74 years) (OR = 1.21, 95% CI = 0.65, 2.25) compared to younger old (50-64 years).

Conclusion: This study suggests that age, education, source of drinking water, household source of income, and financial situation are important for nutritional wellness of aged persons who are HIV infected in South Africa. Moreover, having HIV infection is associated with low nutritional wellness. Being a young old (65-74 years) and receiving government grants and with better financial situation is associated with high nutritional wellness. Stakeholders and agencies who have interest in aged persons affected by HIV must understand the socioeconomic status in relation to their nutritional wellness. The results are of great importance to ageing policies, specifically in health and nutrition.

简介本研究旨在调查南非索姆凯莱(Somkhele)感染艾滋病毒的老年人的营养健康状况:数据摘自 2013 年南非-SAGE 老年人健康研究 (WOPS) 第 2 波。该研究抽样调查了 440 名老年人(50 岁及以上)。根据主要协变量对营养健康状况良好的老年人比例进行了秩和检验,并得出了 P 值(P < 0.05)。对两级二元逻辑回归模型进行了拟合:结果表明,受访者中老年女性(79.8%)多于男性(20.2%),年龄以 50-64 岁为主(65.7%)。丧偶(39.5%)和未受过正规教育(46.1%)的老年人比例较高。每 10 位老年人中就有 6 位感染了艾滋病毒(59.5%)。高营养男性的百分比分布较高(78.7%)。回归结果显示,与未感染者相比,感染艾滋病毒的老年人营养状况较差(OR = 0.74,95% CI = 0.69,1.26)。就受访者的年龄而言,与较年轻的受访者(50-64 岁)相比,年轻受访者(65-74 岁)的营养健康水平较高(OR = 1.21,95% CI = 0.65,2.25):本研究表明,年龄、教育程度、饮用水源、家庭收入来源和经济状况对南非感染艾滋病毒的老年人的营养健康非常重要。此外,感染艾滋病毒与营养不良也有关联。年轻的老年人(65-74 岁)、接受政府补助且经济状况较好的老年人营养健康状况较好。关注受艾滋病毒影响的老年人的利益相关者和机构必须了解他们的社会经济状况与营养健康的关系。研究结果对老龄化政策,特别是健康和营养政策具有重要意义。
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引用次数: 0
Physical Performance in Older Cohorts: A Comparison of 81-Year-Old Swedish Men and Women Born Twelve Years Apart-Results from the Swedish Study "Good Aging in Skåne". 老年人群的身体表现:81岁瑞典男性和出生相隔12年的女性的比较——来自瑞典研究“sk<s:1>良好衰老”的结果。
IF 4.7 Q4 GERIATRICS & GERONTOLOGY Pub Date : 2021-06-05 eCollection Date: 2021-01-01 DOI: 10.1155/2021/8813992
Henrik Ekström, Sölve Elmståhl, Lena Sandin Wranker

Materials and methods: Birth cohorts of both sexes drawn from the Swedish study "Good Aging in Skåne" for the years 1920-22 and 1932-34 were compared. Walking, the step test, the chair stand test, and the handgrip strength test were used as proxies for the physical performance. The results were adjusted for lifestyle habits and common chronic geriatric diseases.

Results: Both men and women in the later-born cohort walked more quickly and completed the chair stand test faster, and women were also quicker in the step test. No significant differences were found in the grip test, in either the male or female cohorts. Discussion. Normative reference values for physical tests of subjects of different ages can be misleading unless cohort effects are considered. Furthermore, age-related trajectories can also be misinterpreted if cohort effects are neglected which, in the longer perspective, could affect health care planning.

Conclusion: Birth cohort effects should be considered when comparing walking speed, number of steps, chair stands, and the step test, in men and women of older age.

材料和方法:对1920-22年和1932-34年瑞典研究“sk的良好衰老”中男女出生队列进行比较。以步行测试、踏步测试、椅站测试和握力测试作为身体表现的指标。研究结果根据生活习惯和常见的慢性老年病进行了调整。结果:出生晚的那组男性和女性走路都更快,完成椅子站立测试的速度也更快,女性在踏步测试中也更快。在握力测试中,无论是男性还是女性,都没有发现显著的差异。讨论。除非考虑队列效应,否则不同年龄受试者的体格测试的规范参考值可能具有误导性。此外,如果忽视队列效应,与年龄相关的轨迹也可能被误解,从长远来看,这可能会影响医疗保健规划。结论:在比较老年男性和女性的步行速度、步数、椅架和步数测试时,应考虑出生队列效应。
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引用次数: 0
Effects of a Multicomponent Exercise Program on Groups of Community-Dwelling Older Adults with Low Schooling: A Pilot Study. 多组分运动计划对社区居住低教育老年人群体的影响:一项试点研究。
IF 4.7 Q4 GERIATRICS & GERONTOLOGY Pub Date : 2021-06-03 eCollection Date: 2021-01-01 DOI: 10.1155/2021/8829332
Neildja Maria da Silva, Monalisa Silva de França, Dellis Kariny Freitas Holanda de Almeida, Evelin Suyany Guedes de Lima, Vinícius Hugley Brito Dos Santos, João Victor de Araújo Souza, Ana Rodriguez Larrad, Débora de Almeida Aloise, Núbia Maria Freire Vieira Lima

The aim of this study was to analyze the effects of a multicomponent exercise program on the physical and hemodynamic functions of community-dwelling older adults with low schooling levels in relation to simple multicomponent group exercises. Twenty-one older people were randomly assigned to two groups: G1 (n = 11) and G2 (n = 10); sixteen of whom completed the sixteen sessions over a six-week period, three times a week. During eight sessions, G1 performed adapted dual-task multicomponent exercises (strengthening, balance, and cognition) and G2 simple multicomponent exercises (strengthening and balance), and both groups engaged in eight additional sessions of simple multicomponent exercises. The dual-task multicomponent exercises exhibited similar effects to those of their simple multicomponent counterparts. The older adults from both groups improved mobility, frailty, static postural control, balance, and hemodynamic stability. The adapted program was beneficial to the community-dwelling older people with low schooling in the group intervention.

本研究的目的是分析多组分锻炼计划对低教育水平社区居住老年人的身体和血液动力学功能的影响,并与简单的多组分团体锻炼相关联。21名老年人随机分为两组:G1 (n = 11)和G2 (n = 10);其中16人在6周的时间内完成了16次疗程,每周三次。在8个疗程中,G1进行适应性双任务多组分练习(强化、平衡和认知),G2进行简单多组分练习(强化和平衡),两组都进行了8个额外的简单多组分练习。双任务多成分练习与简单多成分练习表现出相似的效果。两组老年人的活动能力、虚弱、静态姿势控制、平衡和血流动力学稳定性均得到改善。在团体干预中,调整后的方案对社区居住的低教育程度老年人是有益的。
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引用次数: 5
Definitions of Frailty in Qualitative Research: A Qualitative Systematic Review. 质性研究中脆弱性的定义:质性系统回顾。
IF 4.7 Q4 GERIATRICS & GERONTOLOGY Pub Date : 2021-06-02 eCollection Date: 2021-01-01 DOI: 10.1155/2021/6285058
Deborah A Lekan, Susan K Collins, Audai A Hayajneh

The purpose of this qualitative systematic review was to examine how frailty was conceptually and operationally defined for participant inclusion in qualitative research focused on the lived experience of frailty in community-living frail older adults. Search of six electronic databases, 1994-2019, yielded 25 studies. Data collection involved extracting the definition of frailty from the study aim, background, literature review, methods, and sampling strategy in each research study. Quality appraisal indicated that 13 studies (52%) demonstrated potential researcher bias based on insufficient information about participant recruitment, sampling, and relationship between the researcher and participant. Content analysis and concept mapping were applied for data synthesis. Although frailty was generally defined as a multidimensional, biopsychosocial construct with loss of resilience and vulnerability to adverse outcomes, most studies defined the study population based on older age and physical impairments derived from subjective assessment by the researcher, a healthcare professional, or a family member. However, 13 studies (52%) used objective or performance-based quantitative measures to classify participant frailty. There was no consistency across studies in standardized measures or objective assessment of frailty. Synthesis of the findings yielded four themes: Time, Vulnerability, Loss, and Relationships. The predominance of older age and physical limitations as defining characteristics of frailty raises questions about whether participants were frail, since many older adults at advanced age and with physical limitations are not frail. Lack of clear criteria to classify frailty and reliance on subjective assessment introduces the risk for bias, threatens the validity and interpretation of findings, and hinders transferability of findings to other contexts. Clear frailty inclusion and exclusion criteria and a standardized approach in the reporting of how frailty is conceptually and operationally defined in study abstracts and the methodology used is necessary to facilitate dissemination and development of metasynthesis studies that aggregate qualitative research findings that can be used to inform future research and applications in clinical practice to improve healthcare.

本定性系统回顾的目的是研究如何在概念上和操作上定义脆弱,以便在定性研究中纳入参与者,重点关注社区生活体弱老年人的脆弱生活经验。在1994-2019年的6个电子数据库中检索,获得了25项研究。数据收集包括从每项研究的研究目的、背景、文献综述、方法和抽样策略中提取脆弱性的定义。质量评估表明,13项研究(52%)显示出潜在的研究者偏见,这是基于参与者招募、抽样和研究者与参与者之间关系的信息不足。应用内容分析和概念映射进行数据综合。虽然虚弱通常被定义为一种多维的、生物心理社会结构,具有恢复力的丧失和对不良结果的脆弱性,但大多数研究是基于年龄和研究者、医疗保健专业人员或家庭成员主观评估得出的身体损伤来定义研究人群的。然而,13项研究(52%)使用客观或基于表现的定量措施对参与者的虚弱进行分类。在虚弱的标准化测量或客观评估方面,研究之间没有一致性。综合研究结果得出了四个主题:时间、脆弱、失去和关系。年龄较大和身体限制作为虚弱的定义特征的优势引发了关于参与者是否虚弱的问题,因为许多年龄较大和身体限制的老年人并不虚弱。缺乏对脆弱进行分类的明确标准和对主观评估的依赖会带来偏见的风险,威胁到研究结果的有效性和解释,并阻碍研究结果在其他情况下的可转移性。明确的脆弱性纳入和排除标准,以及在报告研究摘要中如何在概念和操作上定义脆弱性的标准化方法,以及所使用的方法,对于促进meta合成研究的传播和发展是必要的,meta合成研究汇总了定性研究结果,可用于为未来的研究和临床实践中的应用提供信息,以改善医疗保健。
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引用次数: 10
Strategies to Locate Lost Persons with Dementia: A Case Study of Ontario First Responders. 定位失智者的策略:安大略省急救人员的案例研究。
IF 4.7 Q4 GERIATRICS & GERONTOLOGY Pub Date : 2021-05-15 eCollection Date: 2021-01-01 DOI: 10.1155/2021/5572764
N A Neubauer, A Miguel-Cruz, L Liu

Information on strategies and practices in the search of missing persons with dementia is inconsistent which creates challenges for first responders, such as police, when they choose appropriate search and rescue approaches. The purpose of this study was to describe current strategies among police services in Ontario. Telephone interviews with police were conducted. Questions included what strategies were used for locating missing persons living with dementia, and what gaps exist in search practices. Participants described they used high- and low-tech solutions in search and rescue. They identified gaps in education and awareness, proactive strategies, resources, and funding. Information collected from the interviews was used to develop a practice guideline for police in partnership with the Alzheimer Society of Ontario.

关于寻找失智症失踪人员的战略和做法的信息不一致,这给警察等第一反应者在选择适当的搜索和救援方法时带来了挑战。本研究的目的是描述安大略省警察部门的当前战略。警方进行了电话采访。问题包括使用什么策略来寻找患有痴呆症的失踪人员,以及搜索实践中存在哪些差距。与会者描述了他们在搜索和救援中使用的高科技和低技术解决方案。他们确定了教育和意识、主动战略、资源和资金方面的差距。从访谈中收集的信息被用于与安大略省阿尔茨海默病协会合作,为警察制定一项实践指南。
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引用次数: 5
Reliability of Lower Extremity Muscle Power and Functional Performance in Healthy, Older Women. 健康老年妇女下肢肌力和功能表现的可靠性
IF 4.7 Q4 GERIATRICS & GERONTOLOGY Pub Date : 2021-02-17 eCollection Date: 2021-01-01 DOI: 10.1155/2021/8817231
Konstantina Katsoulis, Sunita Mathur, Catherine E Amara

Evaluation of the long-term reliability of muscle power and functional performance tests in older, healthy adults is warranted since determining whether performance is consistent over longer durations is more relevant for intervention studies. Objective. To assess the long-term test-retest reliability of measures of muscle power and lower body functional performance in healthy, nonexercising, older women. Methods. Data were derived from a nonexercising control group (n = 18; age = 73.3 (3.4) years; height = 159.6 (7.7) cm; body mass = 69.5 (12.7) kg; BMI = 27.3 (4.8)) of a randomized controlled trial of muscle power training in older women. Participants underwent lower extremity muscle power (Biodex) and functional testing (Short Physical Performance Battery, gait speed, 30-second chair stands, stair climbing, and 400-meter walk) at week 0 (baseline), 9, and 15. Results. For the upper leg, intraclass correlation coefficients (ICCs) were very high for knee extension power (0.90-0.97) and high to very high for knee flexion power (0.83-0.96). For lower-leg power, ICCs were high to very high for plantar flexion and dorsiflexion (0.83-0.96). ICCs for functional performance were moderate to very high (0.64-0.93). Coefficient of variation of the typical error (CVTE) was <10.5% for knee extension/flexion power, 9.9-20.0% for plantar flexion/dorsiflexion power, and 1.9-14.9% for functional performance. Knee extension power and stair climb power demonstrated the highest reliability for muscle power and function, respectively. Mean values did not change over time, with the exception of the chair stands (p < 0.05); however, these changes were not considered clinically meaningful. Conclusions. The current study provides evidence supporting the long-term reliability of performance assessments of muscle power and lower body functional capacity over a period of up to 15 weeks in healthy, older women.

对健康老年人肌肉力量和功能表现测试的长期可靠性进行评估是有必要的,因为确定在更长时间内的表现是否一致与干预研究更相关。目标。评估健康、不运动的老年妇女肌肉力量和下肢功能表现测量的长期重测可靠性。方法。数据来自非运动对照组(n = 18;年龄= 73.3(3.4)岁;身高= 159.6 (7.7)cm;体重= 69.5 (12.7)kg;在老年妇女肌肉力量训练的随机对照试验中,BMI = 27.3(4.8)。参与者在第0周(基线)、第9周和第15周接受了下肢肌肉力量(Biodex)和功能测试(短物理性能电池、步态速度、30秒站立椅子、爬楼梯和400米步行)。结果。对于上肢,膝关节伸展力的类内相关系数(ICCs)非常高(0.90-0.97),膝关节屈曲力的类内相关系数(ICCs)非常高(0.83-0.96)。对于下肢力量,足底屈曲和背屈时ICCs高至非常高(0.83-0.96)。功能表现的ICCs为中等至非常高(0.64-0.93)。典型误差变异系数(CVTE) p < 0.05;然而,这些变化被认为没有临床意义。结论。目前的研究提供了证据,支持对健康老年妇女长达15周的肌肉力量和下肢功能能力性能评估的长期可靠性。
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引用次数: 1
Gaps in Hospice and Palliative Care Research: A Scoping Review of the North American Literature. 安宁疗护与缓和疗护研究的空白:北美文献综述。
IF 4.7 Q4 GERIATRICS & GERONTOLOGY Pub Date : 2020-11-05 eCollection Date: 2020-01-01 DOI: 10.1155/2020/3921245
Rebecca Antonacci, Carol Barrie, Sharon Baxter, Sarah Chaffey, Srini Chary, Pamela Grassau, Chad Hammond, Mehrnoush Mirhosseini, Raza M Mirza, Kate Murzin, Christopher A Klinger

Background: The demand for hospice and palliative care is growing as a result of the increase of an aging population, which is most prominent in North America. Despite the importance of the topic and an increase in hospice and palliative care utilization, there still are gaps in research and evidence within the field.

Aim: To determine what gaps currently exist in hospice and palliative/end-of-life care research within the context of a North American setting to ensure that future directions are grounded in appropriate evidence.

Methods: Using Arksey and O'Malley's scoping review framework, six peer-reviewed, and four grey electronic literature databases in healthcare and the social sciences were searched in mid-2019. 111 full-text articles were retrieved, with 25 articles and reports meeting the inclusion criteria. Major themes were identified through thematic context analysis: (1) clinical, (2) system access to care, (3) research methodology, and (4) caregiving-related research gaps.

Results: Findings include strategies for engaging stakeholder organizations and funding agencies, implications for other stakeholder groups such as clinicians and researchers, and highlight implications for policy (e.g., national framework discussion) and practice (e.g., healthcare provider education and training and public awareness).

Conclusion: Reviewing and addressing targeted research gaps is essential to inform future directions in Canada and beyond.

背景:由于人口老龄化的增加,对临终关怀和姑息治疗的需求正在增长,这在北美最为突出。尽管这个话题很重要,临终关怀和姑息治疗的使用也在增加,但在该领域的研究和证据方面仍然存在差距。目的:确定目前在北美环境下临终关怀和缓和/临终关怀研究中存在的差距,以确保未来的方向以适当的证据为基础。方法:利用Arksey和O'Malley的范围审查框架,检索2019年年中医疗保健和社会科学领域的6个同行评议电子文献数据库和4个灰色电子文献数据库。检索到111篇全文文章,其中25篇文章和报告符合纳入标准。通过主题背景分析确定了主要主题:(1)临床,(2)系统获得护理,(3)研究方法,(4)护理相关研究差距。结果:调查结果包括使利益攸关方组织和供资机构参与的战略,对临床医生和研究人员等其他利益攸关方群体的影响,并强调对政策(例如,国家框架讨论)和实践(例如,医疗保健提供者教育和培训以及公众意识)的影响。结论:审查和解决有针对性的研究差距是至关重要的,以告知未来的方向在加拿大和超越。
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引用次数: 6
Circulating Interleukin-6 (but Not Other Immune Mediators) Associates with Criteria for Fried's Frailty among Very Old Adults. 循环白细胞介素-6(而不是其他免疫介质)与高龄成年人弗里德氏病的标准相关
IF 4.7 Q4 GERIATRICS & GERONTOLOGY Pub Date : 2020-11-04 eCollection Date: 2020-01-01 DOI: 10.1155/2020/6831791
Gilberto Santos Morais Junior, Diego Ignacio Valenzuela Perez, Audrey Cecília Tonet-Furioso, Lucy Gomes, Karla Helena Coelho Vilaça, Vicente Paulo Alves, Clayton Franco Moraes, Otávio Toledo Nóbrega
Methods One hundred and sixty-one very old patients (aged ≥80 years) devoid of cognitive decline were eligible for analyses. Clinical and biochemical data along with physical and cognitive assessments encompassing dual-energy X-ray scans and hand dynamometry were adopted to investigate frailty criteria, while circulating immune mediators (IFNγ, IL-2, IL-4, IL-6, IL-10, and TNFα) were assessed using high-throughput flow cytometry. Results Preliminarily, IL-6 correlated positively with waist-to-hip ratio and C-reactive protein and negatively with glycemia. In analyses controlled for these factors, serum levels of IL-6 were comparatively augmented among the very old participants with reduced grip strength (OR = 3.299; 95% CI 1.08–6.09; p=0.032) and among those with slow walk speed (OR = 2.460; 95% CI 1.16–7.05; p=0.022). Conclusions Our study shows a strong negative correlation of IL-6 levels with Fried's frailty components of grip strength and walk speed in very old adults, regardless of confounding factors.
方法:161例无认知能力下降的高龄患者(年龄≥80岁)符合分析条件。采用临床和生化数据以及包括双能x线扫描和手部动力测量在内的身体和认知评估来研究虚弱标准,同时使用高通量流式细胞术评估循环免疫介质(IFNγ, IL-2, IL-4, IL-6, IL-10和TNFα)。结果:初步表明,IL-6与腰臀比、c反应蛋白呈正相关,与血糖呈负相关。在控制这些因素的分析中,握力降低的高龄参与者血清IL-6水平相对增加(OR = 3.299;95% ci 1.08-6.09;p=0.032),步行速度慢者(OR = 2.460;95% ci 1.16-7.05;p = 0.022)。结论:我们的研究表明,无论混杂因素如何,IL-6水平与非常老的成年人的握力和步行速度的Fried's脆弱成分有很强的负相关。
{"title":"Circulating Interleukin-6 (but Not Other Immune Mediators) Associates with Criteria for Fried's Frailty among Very Old Adults.","authors":"Gilberto Santos Morais Junior,&nbsp;Diego Ignacio Valenzuela Perez,&nbsp;Audrey Cecília Tonet-Furioso,&nbsp;Lucy Gomes,&nbsp;Karla Helena Coelho Vilaça,&nbsp;Vicente Paulo Alves,&nbsp;Clayton Franco Moraes,&nbsp;Otávio Toledo Nóbrega","doi":"10.1155/2020/6831791","DOIUrl":"https://doi.org/10.1155/2020/6831791","url":null,"abstract":"Methods One hundred and sixty-one very old patients (aged ≥80 years) devoid of cognitive decline were eligible for analyses. Clinical and biochemical data along with physical and cognitive assessments encompassing dual-energy X-ray scans and hand dynamometry were adopted to investigate frailty criteria, while circulating immune mediators (IFNγ, IL-2, IL-4, IL-6, IL-10, and TNFα) were assessed using high-throughput flow cytometry. Results Preliminarily, IL-6 correlated positively with waist-to-hip ratio and C-reactive protein and negatively with glycemia. In analyses controlled for these factors, serum levels of IL-6 were comparatively augmented among the very old participants with reduced grip strength (OR = 3.299; 95% CI 1.08–6.09; p=0.032) and among those with slow walk speed (OR = 2.460; 95% CI 1.16–7.05; p=0.022). Conclusions Our study shows a strong negative correlation of IL-6 levels with Fried's frailty components of grip strength and walk speed in very old adults, regardless of confounding factors.","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2020 ","pages":"6831791"},"PeriodicalIF":4.7,"publicationDate":"2020-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/6831791","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38854575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Loneliness Relates to Functional Mobility in Older Adults with Type 2 Diabetes: The Look AHEAD Study. 孤独感与老年2型糖尿病患者的功能活动能力有关:前瞻性研究
IF 4.7 Q4 GERIATRICS & GERONTOLOGY Pub Date : 2020-10-30 eCollection Date: 2020-01-01 DOI: 10.1155/2020/7543702
Jeanne M McCaffery, Andrea Anderson, Mace Coday, Mark A Espeland, Amy A Gorin, Karen C Johnson, William C Knowler, Candice A Myers, W Jack Rejeski, Helmut O Steinberg, Andrew Steptoe, Rena R Wing

Objective: Little is known about the impact of loneliness on physical health among elderly individuals with diabetes. Here, we examined the relationship of loneliness with disability, objective physical function, and other health outcomes in older individuals with type 2 diabetes and overweight or obesity.

Method: Data are drawn from the Look AHEAD study, a diverse cohort of individuals (ages 61-92) with overweight or obesity and type 2 diabetes measured 5-6 years after a 10-year weight loss randomized, controlled trial.

Results: Loneliness scores were significantly associated with greater disability symptoms and slower 4-meter gait speed (ps < 0.01). Loneliness did not differ across treatment arms. Discussion. Overall, these results extend prior findings relating loneliness to disability and decreased mobility to older individuals with type 2 diabetes and overweight or obesity.

目的:孤独感对老年糖尿病患者身体健康的影响尚不清楚。在这里,我们研究了孤独与残疾、客观身体功能和其他健康结果在患有2型糖尿病和超重或肥胖的老年人中的关系。方法:数据来自Look AHEAD研究,这是一项不同的队列研究(61-92岁),超重或肥胖和2型糖尿病患者在10年体重减轻后的5-6年随机对照试验。结果:孤独感得分与残疾症状加重、4米步速减慢相关(ps < 0.01)。孤独感在治疗组之间没有差异。讨论。总的来说,这些结果扩展了先前关于孤独与残疾和行动能力下降有关的发现,适用于患有2型糖尿病和超重或肥胖的老年人。
{"title":"Loneliness Relates to Functional Mobility in Older Adults with Type 2 Diabetes: The Look AHEAD Study.","authors":"Jeanne M McCaffery,&nbsp;Andrea Anderson,&nbsp;Mace Coday,&nbsp;Mark A Espeland,&nbsp;Amy A Gorin,&nbsp;Karen C Johnson,&nbsp;William C Knowler,&nbsp;Candice A Myers,&nbsp;W Jack Rejeski,&nbsp;Helmut O Steinberg,&nbsp;Andrew Steptoe,&nbsp;Rena R Wing","doi":"10.1155/2020/7543702","DOIUrl":"https://doi.org/10.1155/2020/7543702","url":null,"abstract":"<p><strong>Objective: </strong>Little is known about the impact of loneliness on physical health among elderly individuals with diabetes. Here, we examined the relationship of loneliness with disability, objective physical function, and other health outcomes in older individuals with type 2 diabetes and overweight or obesity.</p><p><strong>Method: </strong>Data are drawn from the Look AHEAD study, a diverse cohort of individuals (ages 61-92) with overweight or obesity and type 2 diabetes measured 5-6 years after a 10-year weight loss randomized, controlled trial.</p><p><strong>Results: </strong>Loneliness scores were significantly associated with greater disability symptoms and slower 4-meter gait speed (<i>ps</i> < 0.01). Loneliness did not differ across treatment arms. <i>Discussion</i>. Overall, these results extend prior findings relating loneliness to disability and decreased mobility to older individuals with type 2 diabetes and overweight or obesity.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2020 ","pages":"7543702"},"PeriodicalIF":4.7,"publicationDate":"2020-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/7543702","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38591221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
期刊
Journal of Aging Research
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