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Exploring Changes in Barriers and Facilitators for Physical Activity during the Retirement Transition: A Qualitative Interview Study Based on the Behavior Change Wheel. 探索退休过渡期体育活动障碍和促进因素的变化:基于行为改变轮的定性访谈研究。
IF 1.6 Q4 GERIATRICS & GERONTOLOGY Pub Date : 2024-09-16 eCollection Date: 2024-01-01 DOI: 10.1155/2024/3257287
Nina Vansweevelt, Jannique van Uffelen, Filip Boen, Jan Seghers

The retirement transition has been associated with a decrease in total physical activity (PA). However, little is known about effective interventions to counteract this decrease. Prior to designing interventions, more information is needed about the changes in PA and in determinants of PA around this life change. Therefore, the first aim of this study was to investigate perceived changes in PA. The second aim was to explore the changes in PA barriers and facilitators experienced by recent retirees. Semistructured interviews were conducted with 30 retirees six to ten months after their retirement transition. The interview guide consisted of open questions as well as specific questions based on the "behavior change wheel" (BCW). The analysis of the interviews involved an initial inductive reflexive thematic analysis, followed by deductive mapping of the themes onto the COM-B categories, which are an integral part of the BCW. Most retirees experienced an increase in PA. The first inductive theme regarding changes in barriers and facilitators for PA was labelled as "changes in time availability and time structure." For instance, one of the facilitators was that increased time availability led to more PA. However, as a barrier, it was noted that this sometimes resulted in increased procrastination as well. The second theme was labelled "emotional/mental changes" and included facilitators such as a decreased feeling of being useful with consequent uptake of new purposeful (physical) activities. Conversely, a perceived barrier was the idea that reduced PA is allowed after retirement. The third theme, "social changes," highlights for instance the facilitator that many participants expressed an increased desire to expand their social network for shared (physical) activities. The identified themes were mapped onto the COM-B categories and potential intervention functions were discussed.

退休过渡期与总体力活动(PA)的减少有关。然而,人们对抵消这种减少的有效干预措施知之甚少。在设计干预措施之前,我们需要更多的信息来了解围绕这一生活变化的 PA 变化以及 PA 的决定因素。因此,本研究的第一个目的是调查 PA 的感知变化。第二个目的是探究近期退休人员在锻炼障碍和促进因素方面的变化。研究人员在 30 名退休人员退休 6 至 10 个月后对他们进行了半结构式访谈。访谈指南包括开放式问题以及基于 "行为改变轮"(BCW)的具体问题。对访谈的分析包括初步的归纳反思性主题分析,然后将主题与作为 BCW 重要组成部分的 COM-B 类别进行演绎映射。大多数退休人员的 PA 都有所增加。第一个归纳性主题是 "可支配时间和时间结构的变化",涉及活动量的障碍和促进因素的变化。例如,促进因素之一是可利用时间的增加导致了更多的公共活动。然而,作为一种障碍,有人指出,这有时也会导致拖延现象的增加。第二个主题被称为 "情绪/心理变化",包括促进因素,如减少了有用的感觉,从而接受了 新的有目的的(身体)活动。与此相反,退休后允许减少体育活动的想法则是一个明显的障碍。第三个主题 "社会变革 "突出了促进因素,例如许多参与者表示更希望扩大他们的社交网络,以共享(体育)活动。我们将确定的主题映射到 COM-B 类别中,并讨论了潜在的干预功能。
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引用次数: 0
Nurses' Perspectives and Understanding of Sarcopenia in a Tertiary Care Hospital. 一家三甲医院护士对 "肌肉疏松症 "的看法和理解。
IF 1.6 Q4 GERIATRICS & GERONTOLOGY Pub Date : 2024-09-12 eCollection Date: 2024-01-01 DOI: 10.1155/2024/9106500
Kanjana Khuankaew, Panita Limpawattana, Manchumad Manjavong, Nutwara Saengwijit, Khanyanut Ojongpien, Prapassawan Tanlawan

Background: Sarcopenia is prevalent in older adults. It is essential for nurses to sustain updated information regarding the knowledge of sarcopenia, particularly in relation to approaches to diagnosing and addressing sarcopenia. However, there are limited studies examining the attitudes and awareness of nurses in relation to this condition.

Objective: To assess the attitude and knowledge of nurses regarding sarcopenia and correlation between positive attitude and scores on knowledge.

Materials and methods: An electronic survey was carried out among the nurses of the Faculty of Medicine, Khon Kaen University, Thailand, during November 2022 and January 2024. This survey encompassed questionnaires aimed at evaluating the nurses' perspectives and understanding of sarcopenia. The participants were invited to complete the survey, and they were returned to the researchers for analysis.

Results: A total of 231 nurses were recruited (response rate 46.2%). Only 58.4% of them were familiar with "sarcopenia," while only 16% had confidence in diagnosing it. For general knowledge, they achieved a total score of 19/30 (63.3%). They demonstrated proficiency in "etiology" (75%), while their performance was fair in "management and prevention" (62.5%) and low in "terminology & importance" (50%) and "diagnosis" (50%). The correlation between positive attitude and knowledge on sarcopenia was 0.22 (p < 0.05).

Conclusion: Nurses exhibited a reduced awareness regarding "sarcopenia." Their comprehension about terminology, diagnosis, prevention, and management of this condition was limited. There was a weak correlation between positive attitude and knowledge. The findings emphasize the essentiality of augmenting the educational programs to enhance the recognition of sarcopenia among nurses.

背景:肌肉疏松症在老年人中很普遍。护士必须不断更新有关肌肉疏松症的知识,特别是有关诊断和治疗肌肉疏松症的方法。然而,有关护士对这种疾病的态度和认识的研究却很有限:评估护士对肌肉疏松症的态度和知识,以及积极态度与知识得分之间的相关性:在 2022 年 11 月至 2024 年 1 月期间,对泰国孔敬大学医学院的护士进行了一项电子调查。该调查包括旨在评估护士对肌肉疏松症的看法和理解的问卷。研究人员邀请参与者填写调查问卷,并将问卷交回研究人员进行分析:共招募了 231 名护士(回复率为 46.2%)。其中只有 58.4% 的人熟悉 "肌少症",只有 16% 的人对诊断肌少症有信心。在常识方面,他们的总得分为 19/30(63.3%)。他们在 "病因学 "方面表现熟练(75%),而在 "管理和预防 "方面表现一般(62.5%),在 "术语和重要性"(50%)和 "诊断"(50%)方面表现较低。积极态度与对肌肉疏松症的了解之间的相关性为 0.22(p 结论:护士对肌肉疏松症的了解较少:护士对 "肌肉疏松症 "的认识不足。她们对肌肉疏松症的术语、诊断、预防和管理的理解有限。积极态度与知识之间的相关性较弱。研究结果强调,必须加强教育计划,提高护士对 "肌肉疏松症 "的认识。
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引用次数: 0
Lack of Intensity Control during an Exercise Program Is Related to a Limited Effect on Variables Responsible for Blood Pressure Regulation in Hypertensive Older Adults. 运动项目中缺乏强度控制对高血压老年人血压调节变量的影响有限
IF 1.6 Q4 GERIATRICS & GERONTOLOGY Pub Date : 2024-06-27 eCollection Date: 2024-01-01 DOI: 10.1155/2024/3128257
Roberta Fernanda da Silva, Thaís Amanda Reia, André Mourão Jacomini, Anderson Bernadino da Silva, Henrique Dos Santos Disessa, Henrique Luiz Monteiro, Anderson Saranz Zago

To compare the effect of an intensity-controlled exercise program (ICEP) and a nonintensity-controlled exercise program (non-ICEP) on the variables responsible for blood pressure regulation in hypertensive older adults. 95 hypertensive older adults (65.40 ± 7.48 years/22 males and 73 females) performed hemodynamic, functional fitness, and biochemical evaluations before and after 12 weeks of the multicomponent exercises which included walking, muscle strength, hydrogymnastics, Pilates, dynamic balance, agility, flexibility, and others. A significant improvement was observed in general functional fitness index (GFFI: p ≤ 0.000, d = 0.35), nitrite (NO2 -: p ≤ 0.000, d = 0.49), systolic blood pressure (SBP: p ≤ 0.000, d = 0.65), diastolic blood pressure (DBP: p ≤ 0.013, d = 0.40), thiobarbituric acid reactive substances (TBARS: p ≤ 0.007, d = 0.78), activity of the endothelial superoxide dismutase enzyme (ecSOD: p ≤ 0.032, d = 0.41), double product (DP: p ≤ 0.015, d = 0.43), and waist-hip ratio (WHR: p ≤ 0.000, d = 0.44) for ICEP. Only GFFI (p ≤ 0.047, d = 0.12), TBARS (p ≤ 0.000, d = 0.77), SOD (p ≤ 0.025, d = 0.25), DP (p ≤ 0.046, d = 0.26), and BMI (p ≤ 0.018, d = 0.02) presented better results in non-ICEP. When the effect of the groups (controlled by age, BMI, and sex) was evaluated, an increase was observed in the NO2 -, TBARS, and SOD and a reduction in the SBP and WHR variables in the ICEP group compared to the non-ICEP group. Twelve weeks of engagement in a controlled-intensity exercise program was enough to improve the level of functional fitness and variables regarding blood pressure regulation in hypertensive older adults. Conversely, physical exercise performed without intensity control was related to the limited effect on such variables.

目的:比较强度控制运动计划(ICEP)和非强度控制运动计划(非 ICEP)对高血压老年人血压调节变量的影响。95 名高血压老年人(65.40 ± 7.48 岁/22 名男性和 73 名女性)在进行为期 12 周的多成分运动(包括步行、肌肉力量、水上体操、普拉提、动态平衡、敏捷性、柔韧性等)前后,接受了血液动力学、功能性体能和生化评估。40)、硫代巴比妥酸活性物质(TBARS:p ≤ 0.007,d = 0.78)、内皮超氧化物歧化酶活性(ecSOD:p ≤ 0.032,d = 0.41)、双乘积(DP:p ≤ 0.015,d = 0.43)和腰臀比(WHR:p ≤ 0.000,d = 0.44)对 ICEP 的影响。只有 GFFI(p ≤ 0.047,d = 0.12)、TBARS(p ≤ 0.000,d = 0.77)、SOD(p ≤ 0.025,d = 0.25)、DP(p ≤ 0.046,d = 0.26)和 BMI(p ≤ 0.018,d = 0.02)在非 ICEP 中显示出更好的结果。在对各组(按年龄、体重指数和性别控制)的效果进行评估时,观察到与非 ICEP 组相比,ICEP 组的 NO2-、TBARS 和 SOD 增加,SBP 和 WHR 变量减少。参与强度可控的运动计划 12 周足以改善高血压老年人的功能性体能水平和血压调节变量。相反,没有强度控制的体育锻炼对这些变量的影响有限。
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引用次数: 0
Sleep Quality and Subjective Cognitive Decline among Older Adults: The Mediating Role of Anxiety/Depression and Worries. 老年人的睡眠质量与主观认知能力下降:焦虑/抑郁和担忧的中介作用
IF 4.7 Q4 GERIATRICS & GERONTOLOGY Pub Date : 2024-05-07 eCollection Date: 2024-01-01 DOI: 10.1155/2024/4946303
McKenna Sun, Qianqian Zhang, Yifei Han, Jianghong Liu

Background: Subjective cognitive decline (SCD) in older individuals has been implicated as a possible precursor to Alzheimer's disease. Poor sleep quality and anxiety/depressive symptoms have been linked to the progression of SCD, but these associations and older adults' worries have yet to be fully established in the Chinese older adult population, which is one of the largest in the world. The aim of this study was to explore the relationship between sleep quality, anxiety/depression symptoms, and worries, and SCD prevalence among Chinese community-dwelling older individuals.

Methods: A total of 707 adults aged between 60 and 99 from Shanghai, China, completed self-report questionnaires that covered their cognitive and mental well-being, as well as demographic information. Subjective cognitive decline (SCD) was evaluated using the memory/cognition syndromes of the old adult self-report (OASR). Sleep quality, anxiety/depression, and worries were measured from their respective sections of the OASR.

Results: The general linear regression models showed that poorer sleep quality was associated with an increased prevalence of anxiety/depression symptoms, worries, and SCD among older adults. As suggested by the mediation analysis, anxiety/depression and worries were significant mediators in the relationship between sleep quality and SCD prevalence, and these two factors also have a serial mediation effect between sleep quality and SCD prevalence.

Conclusions: Poorer sleep quality is associated with a higher rate of SCD among older adults, and a higher prevalence of anxiety/depression and worries mediate this relationship, suggesting possible mechanism pathways that lead to SCD. These factors may provide the basis for early, targeted interventions for older adults' mental health preservation and improved quality of life.

背景:老年人的主观认知能力下降(SCD)被认为可能是阿尔茨海默病的前兆。睡眠质量差和焦虑/抑郁症状与 SCD 的进展有关,但这些关联和老年人的担忧尚未在中国老年人口中得到充分证实,而中国是世界上老年人口最多的国家之一。本研究旨在探讨中国社区老年人的睡眠质量、焦虑/抑郁症状、忧虑与 SCD 患病率之间的关系:方法:来自中国上海的 707 名年龄在 60 岁至 99 岁之间的成年人填写了自我报告问卷,内容包括他们的认知和精神状况以及人口统计学信息。主观认知衰退(SCD)是通过老年人自我报告的记忆/认知综合征(OASR)进行评估的。睡眠质量、焦虑/抑郁和担忧则根据 OASR 的相应部分进行测量:一般线性回归模型显示,睡眠质量较差与老年人焦虑/抑郁症状、担忧和 SCD 的患病率增加有关。正如中介分析表明的那样,焦虑/抑郁和担忧是睡眠质量与 SCD 患病率之间关系的重要中介因素,而且这两个因素在睡眠质量与 SCD 患病率之间也具有串联中介效应:结论:较差的睡眠质量与老年人较高的 SCD 患病率相关,而较高的焦虑/抑郁和担忧则是这种关系的中介,这表明导致 SCD 的可能机制途径。这些因素可为及早采取有针对性的干预措施以保护老年人的心理健康和提高其生活质量提供依据。
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引用次数: 0
Effects of Mind-Body Qigong Exercise on Overall Health, Fatigue/Sleep, and Cognition in Older Chinese Immigrants in the US: An Intervention Study with Control. 心身气功锻炼对美国老年华人移民整体健康、疲劳/睡眠和认知的影响:带对照的干预研究
IF 1.6 Q4 GERIATRICS & GERONTOLOGY Pub Date : 2024-01-31 eCollection Date: 2024-01-01 DOI: 10.1155/2024/2481518
Jianghong Liu, Yi Yang, Clara Li, Adriana Perez, Adrian Raine, Haoer Shi, Liye Zou

Background: Culturally relevant exercises may help improve health and address disparities faced by older immigrants due to language and cultural barriers. Few studies have focused on such exercise interventions among older Chinese immigrants at US daycare centers.

Methods: We conducted a 10-week nonrandomized controlled trial in older Chinese immigrants in Philadelphia, US. The intervention group practiced Chinese Qigong (Baduanjin) 5 days a week guided by trained research assistants and video instructions. The control group maintained their usual daily activities. We collected self-report assessments on overall health, sleep, and fatigue and implemented two computerized cognitive tests measuring psychomotor vigilance task (PVT) and memory twice, preintervention and postintervention. Repeated measures general linear model (GLM) and paired samples t-tests were used for data analyses.

Results: Eighty-eight older adults (Qigong, n = 53; control, n = 35) with an average age of 78.13 (SD = 5.05) were included. Groups showed no significant differences at baseline evaluation. After the 10-week exercise, the intervention group showed significant improvements in overall health (p=0.032), fatigue (p < 0.001), and cognitive functions including memory (p=0.01), response speed (p=0.002), and response time (p=0.012) on the PVT, as well as marginally significant benefits in sleep (p=0.058). Between-group comparisons identified significant group-by-time interactions in health (p=0.024), sleep (p=0.004), fatigue (p=0.004), and memory (p=0.004).

Conclusion: We revealed significant positive effects of Qigong in older Chinese immigrants across multiple health domains. Findings highlight the potential of a culturally relevant exercise in addressing health disparities.

背景:与文化相关的运动可能有助于改善健康状况,并解决老年移民因语言和文化障碍而面临的不平等问题。很少有研究关注在美国日托中心对中国老年移民进行此类运动干预:我们对美国费城的中国老年移民进行了为期 10 周的非随机对照试验。干预组每周 5 天在训练有素的研究助理和视频指导下练习中国气功(八段锦)。对照组则保持日常活动。我们收集了关于整体健康、睡眠和疲劳的自我报告评估,并在干预前和干预后两次进行了测量精神运动警觉性任务(PVT)和记忆力的计算机化认知测试。数据分析采用重复测量一般线性模型(GLM)和配对样本 t 检验:研究对象包括 88 名老年人(气功组,n = 53;对照组,n = 35),平均年龄为 78.13 岁(SD = 5.05)。各组在基线评估时无明显差异。经过 10 周的锻炼后,干预组在整体健康(p=0.032)、疲劳(p < 0.001)和认知功能(包括记忆力(p=0.01)、反应速度(p=0.002)和反应时间(p=0.012))方面均有明显改善,在睡眠方面也略有改善(p=0.058)。组间比较在健康(p=0.024)、睡眠(p=0.004)、疲劳(p=0.004)和记忆(p=0.004)方面发现了显著的组间时间交互作用:结论:我们发现气功对中国老年移民的多个健康领域都有明显的积极影响。结论:我们发现气功对中国老年移民的多个健康领域都有明显的积极影响。研究结果凸显了与文化相关的运动在解决健康差异方面的潜力。
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引用次数: 0
Do-Not-ResuscitateDecision-Making during the COVID-19 Pandemic in a Teaching Hospital: Lessons Learned for the Future 一家教学医院在 COVID-19 大流行期间的 "不急救 "决策:未来的经验教训
IF 4.7 Q4 GERIATRICS & GERONTOLOGY Pub Date : 2023-12-20 DOI: 10.1155/2023/2771149
Mick van de Wiel, Sabrina van Ierssel, Walter Verbrugghe, Veerle Mertens, A. Janssens
Rationale. Contribute to the understanding of DNR decision-making and conducting end-of-life conversations, about which there is a paucity of data available in the current literature. Aims and Objectives. Assess how the decision-making process to determine a DNR code is implemented in the day-to-day clinical practice in a tertiary teaching hospital. Familiarity with the use of different scores as a possible objective support for DNR decisions and the influence of various elements on a DNR decision was explored. Method. A cross-sectional survey study was conducted between February 2021 and April 2021 for all doctors and doctors in training, working in the Antwerp University Hospital during the COVID-19 pandemic. Results. 127 doctors participated in this study. The familiarity with the different scores used in the triage during the COVID-10 pandemic was 51% for the Clinical Frailty Scale (CFS) and 20% for the Charlson Comorbidity Index (CCI). Participants indicated that their DNR decision is based on various aspects such as clinical assessment, comorbidities, patient’s wishes, age, prognosis, and functional state. Conclusion. The familiarity with the different scores used during triage assessments is low. The total clinical picture of the patient is needed to make a considered decision, and this total picture of the patient seems to be well encompassed by frailty measurement (CFS). Although many participants indicated that the different scores do not offer much added value compared to their clinical assessment, it can help guide DNR decisions, especially for doctors in training.
理由有助于了解 DNR 决策和进行临终对话的情况,目前文献中有关这方面的数据很少。目的和目标。评估一家三级教学医院在日常临床实践中如何实施决定 DNR 代码的决策过程。探讨使用不同评分作为 DNR 决定的可能客观支持的熟悉程度,以及各种因素对 DNR 决定的影响。方法。在 2021 年 2 月至 2021 年 4 月期间,对 COVID-19 大流行期间在安特卫普大学医院工作的所有医生和受训医生进行了横断面调查研究。研究结果127 名医生参与了此次研究。在 COVID-10 大流行期间,临床虚弱量表 (CFS) 和夏尔森合并症指数 (CCI) 的熟悉程度分别为 51% 和 20%。参与者表示,他们会根据临床评估、并发症、患者意愿、年龄、预后和功能状态等多方面因素做出 DNR 决定。结论是对分诊评估中使用的不同评分的熟悉程度较低。要做出深思熟虑的决定,就必须全面了解病人的临床情况,而虚弱程度测量(CFS)似乎就能很好地反映病人的整体情况。尽管许多与会者表示,与他们的临床评估相比,不同的评分并不能提供多少附加值,但它可以帮助指导 DNR 决定,尤其是对正在接受培训的医生而言。
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引用次数: 0
Health Service Utilization and Its Determinants among Senior Citizens in the Semiurban Area of Western Nepal: A Cross-Sectional Study 尼泊尔西部半城市地区老年人对医疗服务的利用及其决定因素:横断面研究
IF 4.7 Q4 GERIATRICS & GERONTOLOGY Pub Date : 2023-12-19 DOI: 10.1155/2023/3655259
Yamuna Chhetri, Dhurba Khatri, N. Gahatraj
Background. Senior citizens are usually infected by multiple chronic conditions and other health problems. Health needs and demand for healthcare services increase with age. However, healthcare services and facilities and their utilization are limited, particularly in developing countries. Aims. To identify the utilization of health services among senior citizens and their contributing factors. Methods. A cross-sectional analytic study was conducted among 293 senior citizens of the Kushma municipality, Nepal, from June to December 2019. A structured questionnaire was used as a data collection tool using a multistage sampling technique. Face-to-face interviews were conducted to collect data on the interview schedule. Reliability and validity were maintained by applying different strategies and carefully developing tools, pretesting, double entry, and validation. Data entry, management, and analysis were performed using Epi Data and SPSS software. Research ethics were maintained. Descriptive and inferential statistical tests were performed to infer the findings. Results. Study participants had a mean age (±SD) of 70.08 (±7.6) years and had various preexisting chronic diseases such as hypertension (46%), gastritis (41.9%), arthritis (34.3%), and asthma (28.7%). Only eight out of ten senior citizens had used health services in the past year. Factors such as age, ethnicity, residency, household income, family support, the presence of chronic diseases, and being under medication were found to have statistically significant associations with the utilization of health services among senior citizens with a p value less than 0.05 and 95% confidence interval. Conclusions. A remarkable proportion of older people reported using health services in the last year. However, a substantial proportion did not utilize health services that require further interventions to enable them. Efforts are required to promote the health and well-being of Nepal’s growing elderly population, including potential enhancements to rural healthcare infrastructure by policymakers.
背景。老年人通常患有多种慢性疾病和其他健康问题。随着年龄的增长,健康需求和对医疗保健服务的需求也随之增加。然而,医疗保健服务和设施及其利用率有限,尤其是在发展中国家。目的确定老年人对医疗服务的利用情况及其诱因。方法。于 2019 年 6 月至 12 月对尼泊尔库什马市的 293 名老年人进行了横断面分析研究。采用多阶段抽样技术,将结构化问卷作为数据收集工具。根据访谈表进行了面对面访谈以收集数据。通过采用不同的策略和精心开发工具、预先测试、重复输入和验证,保持了数据的可靠性和有效性。使用 Epi Data 和 SPSS 软件进行数据录入、管理和分析。遵守研究伦理。对研究结果进行了描述性和推论性统计检验。研究结果研究参与者的平均年龄(±SD)为 70.08(±7.6)岁,患有多种慢性疾病,如高血压(46%)、胃炎(41.9%)、关节炎(34.3%)和哮喘(28.7%)。每 10 位老年人中只有 8 位在过去一年中使用过医疗服务。研究发现,年龄、种族、居住地、家庭收入、家庭支持、是否患有慢性疾病以及是否正在接受药物治疗等因素与老年人使用医疗服务的情况有显著的统计学关联,P 值小于 0.05,置信区间为 95%。结论很大一部分老年人表示在过去一年中使用过医疗服务。然而,有相当一部分老年人并没有利用医疗服务,这就需要采取进一步的干预措施来帮助他们。为促进尼泊尔日益增长的老年人口的健康和福祉,需要做出努力,包括决策者对农村医疗保健基础设施的潜在改进。
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引用次数: 0
Melamine Exacerbates Neurotoxicity in D-Galactose-Induced Neuronal SH-SY5Y Cells. 三聚氰胺加剧了d -半乳糖诱导的神经元SH-SY5Y细胞的神经毒性。
IF 4.7 Q4 GERIATRICS & GERONTOLOGY Pub Date : 2023-11-23 eCollection Date: 2023-01-01 DOI: 10.1155/2023/6635370
Juhi Goyal, Preet Jain, Vivek Jain, Dibyajyoti Banerjee, Rajasri Bhattacharyya, Sharmistha Dey, Rambabu Sharma, Nitish Rai

Numerous studies have depicted the role of diet and environmental toxins in aging. Melamine (Mel) is a globally known notorious food adulterant, and its toxicity has been shown in several organs including the brain. However, till now, there are no reports regarding Mel neurotoxicity in aging neurons. So, this study examined the in vitro neurotoxicity caused by Mel in the D-galactose (DG)-induced aging model of neuronal SH-SY5Y cells. In the present study, the neuronal SH-SY5Y cells were treated with DG and Mel separately and in combination to assess the neurotoxicity potential using MTT assay and neurite length measurement. Further, the superoxide dismutase (SOD), catalase (CAT), and total antioxidant activities were evaluated followed by the determination of the intracellular reactive oxygen species (ROS), mitochondrial membrane potential (MMP), and caspase3 (Casp3) activity. The cotreatment of Mel and DG in neuronal SH-SY5Y cells showed maximum cell death than the cells treated with DG or Mel individually and untreated control cells. The neurite length shrinkage and ROS production were maximum in the DG and Mel cotreated cells showing exacerbated toxicity of Mel. The activity of SOD, CAT, and total antioxidants was also found to be lowered in the cotreatment group (Mel + DG) than in Mel- or DG-treated and untreated cells. Further, the combined toxicity of Mel and DG also elevated the Casp3 activity more than any other group. This is the first study showing the increased neurotoxic potential of Mel in an aging model of neuronal SH-SY5Y cells which implicates that Mel consumption by the elderly may lead to increased incidences of neurodegeneration like Alzheimer's disease and Parkinson's disease.

许多研究都描述了饮食和环境毒素在衰老中的作用。三聚氰胺(Mel)是一种全球闻名的臭名昭著的食品掺假,其毒性已在包括大脑在内的几个器官中显示出来。然而,到目前为止,还没有关于Mel对衰老神经元神经毒性的报道。因此,本研究在d -半乳糖(DG)诱导的神经元SH-SY5Y细胞衰老模型中检测Mel的体外神经毒性。本研究分别用DG和Mel处理神经元SH-SY5Y细胞,并用MTT法和神经突长度测定法评估其神经毒性潜能。进一步,测定细胞内活性氧(ROS)、线粒体膜电位(MMP)和caspase3 (Casp3)活性,评估超氧化物歧化酶(SOD)、过氧化氢酶(CAT)和总抗氧化活性。在SH-SY5Y神经元细胞中,Mel和DG共处理的细胞死亡率高于单独使用DG或Mel处理的细胞和未处理的对照细胞。在DG和Mel共处理的细胞中,神经突长度收缩和ROS产生最大,表明Mel的毒性加剧。与Mel或DG处理和未处理的细胞相比,Mel + DG共处理组的SOD、CAT和总抗氧化剂活性也降低。此外,Mel和DG的联合毒性也比其他任何组更能提高Casp3的活性。这是第一个在神经元SH-SY5Y细胞衰老模型中显示梅尔神经毒性潜力增加的研究,这意味着老年人摄入梅尔可能导致阿尔茨海默病和帕金森病等神经退行性疾病的发病率增加。
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引用次数: 0
Examining Outcomes and Challenges of Telepsychiatry in Australian Elderly: A Scoping Review. 澳大利亚老年人远程精神病学的研究结果和挑战:范围界定综述。
IF 4.7 Q4 GERIATRICS & GERONTOLOGY Pub Date : 2023-10-17 eCollection Date: 2023-01-01 DOI: 10.1155/2023/8864591
Sodabeh Abazari, Khadijeh Moulaei, Manoj George

Methods: To find relevant articles, we searched PubMed, Scopus, and Web of Science databases. We used a data extraction form to gather information from primary studies. Two researchers followed inclusion and exclusion criteria to select studies and extract data. Disagreements were resolved through discussion with all researchers. Studies needed to be in English, about telepsychiatry for Australian seniors, and use any technology type (synchronous, asynchronous, or both). We excluded nontelepsychiatry articles, books, book chapters, conference abstracts, and editor letters.

Results: Telepsychiatry was effectively employed to manage depression, anxiety, delirium, and cognitive impairments. Among these four disorders, telepsychiatry was mostly used for depression. Videoconference and telephone were mostly used to provide telepsychiatry services. Most telepsychiatry services for Australian seniors included "patient education on disorder control and management," "creating continuous interaction between the patient and the therapist," and "remote patients' assessment." "Reductions in symptoms of disorders," "improving patients' satisfaction with telepsychiatry," and "cost-effectiveness of telepsychiatry" were the most important positive outcomes of using telepsychiatry. We also identified four challenges in using telepsychiatry for elderly individuals in Australia.

Conclusions: This study is the first scoping review in Australia and provides valuable insight into telepsychiatry for elderly individuals.

方法:检索PubMed、Scopus和Web of Science数据库中的相关文章。我们使用数据提取表从初步研究中收集信息。两名研究人员遵循纳入和排除标准选择研究并提取数据。分歧通过与所有研究人员的讨论得以解决。研究需要用英语,关于澳大利亚老年人的远程心理,并使用任何技术类型(同步、异步或两者兼有)。我们排除了非电话文章、书籍、书籍章节、会议摘要和编辑信函。结果:远程精神病学被有效地用于治疗抑郁症、焦虑症、谵妄和认知障碍。在这四种疾病中,心灵障碍主要用于治疗抑郁症。视频会议和电话主要用于提供远程心理服务。大多数为澳大利亚老年人提供的远程心理服务包括“关于疾病控制和管理的患者教育”、“在患者和治疗师之间创造持续的互动”以及“远程患者评估”。“减少疾病症状”,“提高患者对远程精神病学的满意度,”和“远程精神病学的成本效益”是使用远程精神病学最重要的积极结果。我们还确定了澳大利亚老年人使用远程精神病学的四个挑战。结论:这项研究是澳大利亚首次范围界定综述,为老年人的远程精神病学提供了有价值的见解。
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引用次数: 0
The Cost-Benefit of Aging: Financial Capability and Well-Being across Age Groups in Brazil. 老龄化的成本效益:巴西不同年龄组的经济能力和幸福感。
IF 4.7 Q4 GERIATRICS & GERONTOLOGY Pub Date : 2023-10-10 eCollection Date: 2023-01-01 DOI: 10.1155/2023/2020189
Eduarda A S R G da Silva, César A T Silva

A large proportion of older persons in developing countries do not have access to pension, which also constrains their ability to afford healthcare services and entails extensive challenges to the well-being of older people. This study aimed to analyze the financial preparedness of different age groups for retirement in Brazil. Data were derived from a survey to empirically validate the proposed relationships between preparedness for retirement and resilience for the future (financial well-being (FWB) outcomes) on the one hand and among demographic and socioeconomic aspects, behaviors and attitudes, knowledge and experience, and "key" psychological factors on the other hand. The sample consisted of 412 individuals aged between 22 and 79 years. FWB was measured using the financial capability and well-being model and regressed on a number of sociodemographic and psychological variables using linear regression analyses. The results demonstrated that preparedness for retirement was strongly related to older age. Additionally, age was correlated with resilience for the future close to zero, which indicates no relationship. Knowledge and the psychological factors of self-control and confidence were positively and strongly related to better financial behavior for all age groups. In addition, grit and resilience for the future were positively related to better financial behavior in the older age group. Furthermore, the variables of retirement contribution were seemingly not viewed as important to the older group compared with their young and mature counterparts. Multidimensional interventions, especially targeting behaviors and psychological patterns, could, therefore, be recommended in advance to young and mature groups to prepare them to secure their old age and achieve FWB.

发展中国家很大一部分老年人无法获得养老金,这也限制了他们负担医疗服务的能力,并给老年人的福祉带来了广泛的挑战。本研究旨在分析巴西不同年龄组的退休财务准备情况。数据来源于一项调查,一方面实证验证了退休准备和对未来的恢复力(财务幸福感(FWB)结果)之间的拟议关系,另一方面又实证验证了人口和社会经济方面、行为和态度、知识和经验以及“关键”心理因素之间的关系。样本由412名年龄在22岁至79岁之间的人组成 年。FWB使用经济能力和幸福感模型进行测量,并使用线性回归分析对一些社会人口和心理变量进行回归。研究结果表明,退休准备与年龄的增长密切相关。此外,年龄与未来的韧性接近零相关,这表明没有关系。在所有年龄组中,知识和自我控制和信心的心理因素与更好的财务行为呈正相关。此外,对未来的毅力和韧性与老年人更好的财务行为呈正相关。此外,与年轻和成熟的同龄人相比,退休供款的变量对老年人来说似乎并不重要。因此,可以提前向年轻和成熟群体推荐多维干预措施,特别是针对行为和心理模式的干预措施,让他们为确保晚年生活和实现FWB做好准备。
{"title":"The Cost-Benefit of Aging: Financial Capability and Well-Being across Age Groups in Brazil.","authors":"Eduarda A S R G da Silva,&nbsp;César A T Silva","doi":"10.1155/2023/2020189","DOIUrl":"https://doi.org/10.1155/2023/2020189","url":null,"abstract":"<p><p>A large proportion of older persons in developing countries do not have access to pension, which also constrains their ability to afford healthcare services and entails extensive challenges to the well-being of older people. This study aimed to analyze the financial preparedness of different age groups for retirement in Brazil. Data were derived from a survey to empirically validate the proposed relationships between <i>preparedness for retirement</i> and <i>resilience for the future</i> (financial well-being (FWB) outcomes) on the one hand and among <i>demographic and socioeconomic</i> aspects, <i>behaviors and attitudes</i>, <i>knowledge and experience</i>, and \"key\" <i>psychological factors</i> on the other hand. The sample consisted of 412 individuals aged between 22 and 79 years. FWB was measured using the financial capability and well-being model and regressed on a number of sociodemographic and psychological variables using linear regression analyses. The results demonstrated that <i>preparedness for retirement</i> was strongly related to older age. Additionally, age was correlated with <i>resilience for the future</i> close to zero, which indicates no relationship. <i>Knowledge</i> and the <i>psychological factors</i> of self-control and confidence were positively and strongly related to better <i>financial behavior</i> for all age groups. In addition, g<i>rit</i> and <i>resilience for the future</i> were positively related to better <i>financial behavior</i> in the older age group. Furthermore, the variables of retirement contribution were seemingly not viewed as important to the older group compared with their young and mature counterparts. Multidimensional interventions, especially targeting <i>behaviors</i> and <i>psychological</i> patterns, could, therefore, be recommended in advance to young and mature groups to prepare them to secure their old age and achieve FWB.</p>","PeriodicalId":14933,"journal":{"name":"Journal of Aging Research","volume":"2023 ","pages":"2020189"},"PeriodicalIF":4.7,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49677683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Journal of Aging Research
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