Pub Date : 2023-01-12DOI: 10.30683/1927-7229.2023.12.01
M. Talaat
Radiotherapy is used to treat patients with head and neck cancers as a primary therapy or as an adjuvant to surgery or chemotherapy. Irradiation results in several complications that can be very overwhelming to the patient. Frequently there is loss of function due to tooth loss, compromised aesthetics, pain and discomfort from xerostomia and mucositis, it also significantly impacts the quality of life. A major advance in dentistry is the successful rehabilitation and replacement of lost teeth by osseointegrated implants. However, the risk of osteoradionecrosis and failure of osseointegration are barriers to implant therapy for those irradiated patients. The aim of this review article is to primarily find out whether the radiotherapy used in the treatment of head and neck cancer patients can affect the success and survival of dental implants according to different studies, and also, to highlight some other pertinent factors that may concurrently influence these implantation. The primary outcome measure shows implants survival in irradiated patients. Most of the studies reported that dental implants can osseointegrate and remain functionally stable in irradiated patients following oral cancer surgery. Accordingly, rehabilitation using dental implants is a viable option for head and neck cancer patients receiving radiotherapy. However, all studies included indicated that survival was significantly higher in non-irradiated patients. Factors such as the mode of radiation therapy delivery, gender, age, implant site and radiation dose at the implant site can affect the survival of dental implant. More research and randomized controlled trails are needed for more accurate judgment.
{"title":"The Influence of Radiation Therapy on Dental Implantation in Head and Neck Cancer Patients","authors":"M. Talaat","doi":"10.30683/1927-7229.2023.12.01","DOIUrl":"https://doi.org/10.30683/1927-7229.2023.12.01","url":null,"abstract":"Radiotherapy is used to treat patients with head and neck cancers as a primary therapy or as an adjuvant to surgery or chemotherapy. Irradiation results in several complications that can be very overwhelming to the patient. Frequently there is loss of function due to tooth loss, compromised aesthetics, pain and discomfort from xerostomia and mucositis, it also significantly impacts the quality of life. \u0000A major advance in dentistry is the successful rehabilitation and replacement of lost teeth by osseointegrated implants. However, the risk of osteoradionecrosis and failure of osseointegration are barriers to implant therapy for those irradiated patients. \u0000The aim of this review article is to primarily find out whether the radiotherapy used in the treatment of head and neck cancer patients can affect the success and survival of dental implants according to different studies, and also, to highlight some other pertinent factors that may concurrently influence these implantation. \u0000The primary outcome measure shows implants survival in irradiated patients. Most of the studies reported that dental implants can osseointegrate and remain functionally stable in irradiated patients following oral cancer surgery. Accordingly, rehabilitation using dental implants is a viable option for head and neck cancer patients receiving radiotherapy. However, all studies included indicated that survival was significantly higher in non-irradiated patients. \u0000Factors such as the mode of radiation therapy delivery, gender, age, implant site and radiation dose at the implant site can affect the survival of dental implant. \u0000More research and randomized controlled trails are needed for more accurate judgment.","PeriodicalId":14957,"journal":{"name":"Journal of Analytical Oncology","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84713728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-28DOI: 10.30683/1927-7229.2022.11.11
D. Tzerkovsky, A. Mazurenko, F.F. Borychevsky, D.V. Shashkouski
Photodynamic Therapy (PDT) is a light-based method that uses photo-reactive molecules, such as different types of photosensitizers (PS), to destroy malignant tumors. As some authors testify, PS was shown to act as a radio-reactive molecule by enhancing generation of reactive oxygen species upon X-ray irradiation. The method of treatment, which is based on the combined use of PS and ionizing radiation, is called «Radiodynamic therapy» (RDT). The advantage of RDT over PDT is the X-ray’s penetrability through tissues, which will find many applications for treatment of deep malignant tumors. The authors of a number of research centers in Japan, Germany, Israel and Lithuania presented the experience of using RDT in experiments on tumor cell lines and animals with transplanted tumors. A clinical approbation of the method has been started in patients with unresectable forms of bladder and cervical cancer, with gliomas and other forms of malignant tumors. The data obtained in experiments on cultures of tumor cells and animals with transplanted tumors indicate a high antitumor efficacy of the RDT with various types of PS. This fact is confirmed by a statistically significant decrease in viable tumor cells with the combined use of RT and PS, as well as a pronounced inhibition of the growth of transplanted tumors compared with the control groups, including the group of radiation therapy in mono mode. The preliminary data obtained show good tolerability of the method in clinical oncology (no serious adverse reactions) and satisfactory antitumor efficacy (an increase in the frequency of objective responses and an increase in the % reduction in tumor volume, which made it possible to transfer them to a resectable state).
{"title":"Radiodynamic Therapy with Photosensitizers: Mini-Review of Experimental and Clinical Studies","authors":"D. Tzerkovsky, A. Mazurenko, F.F. Borychevsky, D.V. Shashkouski","doi":"10.30683/1927-7229.2022.11.11","DOIUrl":"https://doi.org/10.30683/1927-7229.2022.11.11","url":null,"abstract":"Photodynamic Therapy (PDT) is a light-based method that uses photo-reactive molecules, such as different types of photosensitizers (PS), to destroy malignant tumors. As some authors testify, PS was shown to act as a radio-reactive molecule by enhancing generation of reactive oxygen species upon X-ray irradiation. The method of treatment, which is based on the combined use of PS and ionizing radiation, is called «Radiodynamic therapy» (RDT). The advantage of RDT over PDT is the X-ray’s penetrability through tissues, which will find many applications for treatment of deep malignant tumors. The authors of a number of research centers in Japan, Germany, Israel and Lithuania presented the experience of using RDT in experiments on tumor cell lines and animals with transplanted tumors. A clinical approbation of the method has been started in patients with unresectable forms of bladder and cervical cancer, with gliomas and other forms of malignant tumors. The data obtained in experiments on cultures of tumor cells and animals with transplanted tumors indicate a high antitumor efficacy of the RDT with various types of PS. This fact is confirmed by a statistically significant decrease in viable tumor cells with the combined use of RT and PS, as well as a pronounced inhibition of the growth of transplanted tumors compared with the control groups, including the group of radiation therapy in mono mode. The preliminary data obtained show good tolerability of the method in clinical oncology (no serious adverse reactions) and satisfactory antitumor efficacy (an increase in the frequency of objective responses and an increase in the % reduction in tumor volume, which made it possible to transfer them to a resectable state).","PeriodicalId":14957,"journal":{"name":"Journal of Analytical Oncology","volume":"113 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80598304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-14DOI: 10.30683/1927-7229.2022.11.10
P. Šimko, T. Kisková
Lichens produce a plethora of primary and secondary metabolites. Secondary metabolites have several biological functions that can be used for human health. Recent studies have described their antioxidant, anti-inflammatory, antimycotic, and antibiotic/antiviral activities. However, attention has mainly been focused on their antiproliferative, cytotoxic, and anticancer effects. Because there are many publications describing the molecular mechanisms leading to the anticancer effects of lichen secondary metabolites, the aim of this review is to summarize results from current research with the main emphasis on atranorin, usnic and gyrophoric acid.
{"title":"Uncovering the Anticancer Potential of Lichen Secondary Metabolites","authors":"P. Šimko, T. Kisková","doi":"10.30683/1927-7229.2022.11.10","DOIUrl":"https://doi.org/10.30683/1927-7229.2022.11.10","url":null,"abstract":"Lichens produce a plethora of primary and secondary metabolites. Secondary metabolites have several biological functions that can be used for human health. Recent studies have described their antioxidant, anti-inflammatory, antimycotic, and antibiotic/antiviral activities. However, attention has mainly been focused on their antiproliferative, cytotoxic, and anticancer effects. Because there are many publications describing the molecular mechanisms leading to the anticancer effects of lichen secondary metabolites, the aim of this review is to summarize results from current research with the main emphasis on atranorin, usnic and gyrophoric acid.","PeriodicalId":14957,"journal":{"name":"Journal of Analytical Oncology","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81149091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-15DOI: 10.30683/1927-7229.2022.11.09
Vivel Nambiar, K. Koushik, R. Alva
A total of 58 patients who underwent concurrent chemo-radiation for carcinoma cervix were analyzed for magnitude of variation in daily treatment position with two immobilization methods, and its impact on the dose delivered to the organs at risk. Assessment was done with the help electronic portal imaging devices (EPID). The main endpoints of the study were to quantify and compare the total isocentric displacement among the knee rest foot rest and thermoplastic cast groups, and to correlate the effect of isocentric displacement with dose volume changes. The EPIDs were compared with the DRR and set-up errors were noted in X (medio-lateral) Y (antero- posterior) and Z (cranio-caudal) axes. Any variations above the prescribed limits were corrected accordingly before treatment and variations were noted. The root mean square variation in thermoplastic cast group ranged from 0.93 mm to 4.61 mm in X axis, 1.28 mm to 8.07 mm in Y axis, 1.19 mm to 9.49 mm in Z axis. In knee rest foot rest arm these variations are 1.27 mm to 6.05 mm in X axis, 0.91 mm to 4.8 mm in Y axis and 1.09 mm to 5.3 mm in Z axis respectively. P value was significant in Y direction. The total vector error in thermoplastic cast group is 6.308 ± 2.17, and for the knee rest foot rest group was 4.67 ± 1.48. The p value obtained was 0.002, which was statistically significant in favor of knee rest foot rest arm. The bladder, rectum, bowel dose mean differences after isocenter displacement were not statistically significant in both arms.
我们分析了58例同时接受宫颈癌化疗放疗的患者在两种固定方法下每日治疗体位的变化幅度及其对危险器官剂量的影响。使用电子门静脉成像设备(EPID)进行评估。本研究的主要终点是量化和比较膝关节支架、足部支架和热塑性铸造组的总等心位移，并将等心位移的影响与剂量体积变化联系起来。将EPIDs与DRR进行比较，并在X(中外侧)Y(前后)和Z(颅尾)轴上发现设置误差。任何超过规定限度的变化都在治疗前进行相应的纠正，并记录变化。热塑性铸造组的均方根变化范围为X轴0.93 ~ 4.61 mm, Y轴1.28 ~ 8.07 mm, Z轴1.19 ~ 9.49 mm。在膝部、脚部、臂部，X轴变化幅度为1.27 ~ 6.05 mm, Y轴变化幅度为0.91 ~ 4.8 mm, Z轴变化幅度为1.09 ~ 5.3 mm。P值在Y方向上显著。热塑性铸造组的总矢量误差为6.308±2.17，膝关节支架组的总矢量误差为4.67±1.48。得到的p值为0.002，有利于膝关节休息，足部休息，手臂休息。两组等中心移位后膀胱、直肠、肠道剂量均值差异无统计学意义。
{"title":"Comparison of Thermoplastic Cast Versus Knee Wedge/Foot Rest Immobilization Technique in the Treatment of Carcinoma Cervix with Conformal Radiation Therapy","authors":"Vivel Nambiar, K. Koushik, R. Alva","doi":"10.30683/1927-7229.2022.11.09","DOIUrl":"https://doi.org/10.30683/1927-7229.2022.11.09","url":null,"abstract":"A total of 58 patients who underwent concurrent chemo-radiation for carcinoma cervix were analyzed for magnitude of variation in daily treatment position with two immobilization methods, and its impact on the dose delivered to the organs at risk. Assessment was done with the help electronic portal imaging devices (EPID). The main endpoints of the study were to quantify and compare the total isocentric displacement among the knee rest foot rest and thermoplastic cast groups, and to correlate the effect of isocentric displacement with dose volume changes. The EPIDs were compared with the DRR and set-up errors were noted in X (medio-lateral) Y (antero- posterior) and Z (cranio-caudal) axes. Any variations above the prescribed limits were corrected accordingly before treatment and variations were noted. The root mean square variation in thermoplastic cast group ranged from 0.93 mm to 4.61 mm in X axis, 1.28 mm to 8.07 mm in Y axis, 1.19 mm to 9.49 mm in Z axis. In knee rest foot rest arm these variations are 1.27 mm to 6.05 mm in X axis, 0.91 mm to 4.8 mm in Y axis and 1.09 mm to 5.3 mm in Z axis respectively. P value was significant in Y direction. The total vector error in thermoplastic cast group is 6.308 ± 2.17, and for the knee rest foot rest group was 4.67 ± 1.48. The p value obtained was 0.002, which was statistically significant in favor of knee rest foot rest arm. The bladder, rectum, bowel dose mean differences after isocenter displacement were not statistically significant in both arms.","PeriodicalId":14957,"journal":{"name":"Journal of Analytical Oncology","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75502781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-14DOI: 10.30683/1927-7229.2022.11.08
M. Caffo, A. Curcio, Roberta Laera, V. Barresi, G. Caruso
Dural metastases are rare intracranial tumors. They are not sufficiently studied and there are still no specific methods are not to detect them. Differential diagnosis is difficult and only the histologic examination allows a sure diagnosis. We reviewed data records from 2016 to 2020 of patients treated for dural metastases. We included only patients with complete anamnestic history, with both known and unknown primitive cancer. Collected data were compared with recent literature. We operated on 16 single dural metastases, also from very unusual cancers. The most common primitive type of cancer, in our series, was lung tumor, in contrast to prostate cancer, recently reported in literature as the most frequent. A retrospective multicenter study is mandatory to assess new epidemiologic evidences.
{"title":"Intracranial Dural Metastases and Diagnostic Misunderstandings","authors":"M. Caffo, A. Curcio, Roberta Laera, V. Barresi, G. Caruso","doi":"10.30683/1927-7229.2022.11.08","DOIUrl":"https://doi.org/10.30683/1927-7229.2022.11.08","url":null,"abstract":"Dural metastases are rare intracranial tumors. They are not sufficiently studied and there are still no specific methods are not to detect them. Differential diagnosis is difficult and only the histologic examination allows a sure diagnosis. We reviewed data records from 2016 to 2020 of patients treated for dural metastases. We included only patients with complete anamnestic history, with both known and unknown primitive cancer. Collected data were compared with recent literature. We operated on 16 single dural metastases, also from very unusual cancers. The most common primitive type of cancer, in our series, was lung tumor, in contrast to prostate cancer, recently reported in literature as the most frequent. A retrospective multicenter study is mandatory to assess new epidemiologic evidences.","PeriodicalId":14957,"journal":{"name":"Journal of Analytical Oncology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78643544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-10DOI: 10.30683/1927-7229.2022.11.07
Sajad Ahmad Salati, Lamees AlSulaim, A. Rather
Paget’s disease of breast is a cutaneous malignancy of the breast involving the nipple-areolar complex that is often associated with underlying neoplastic lesions of breast parenchyma. This condition is often mistaken for a wide range of dermatological conditions, leading to delay in diagnosis. This review article revisits the etiology, clinical presentation, differential diagnosis, diagnostic work-up, natural history, management and prognosis of Paget’s disease of breast.
{"title":"Paget’s Disease of the Breast (PDB) – A Review","authors":"Sajad Ahmad Salati, Lamees AlSulaim, A. Rather","doi":"10.30683/1927-7229.2022.11.07","DOIUrl":"https://doi.org/10.30683/1927-7229.2022.11.07","url":null,"abstract":"Paget’s disease of breast is a cutaneous malignancy of the breast involving the nipple-areolar complex that is often associated with underlying neoplastic lesions of breast parenchyma. This condition is often mistaken for a wide range of dermatological conditions, leading to delay in diagnosis. This review article revisits the etiology, clinical presentation, differential diagnosis, diagnostic work-up, natural history, management and prognosis of Paget’s disease of breast.","PeriodicalId":14957,"journal":{"name":"Journal of Analytical Oncology","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77098367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-07DOI: 10.30683/1927-7229.2022.11.06
S. Yuasa, Megumi Kabeya, S. Hibi, Y. Shirokawa, Chiaki Tokoro, R. Furuta, S. Nagao, S. Kayukawa, Yoshiteru Tanaka, K. Ina
Epidermal growth factor receptor (EGFR) has received significant attention for its therapeutic potential for pain relief. The relief of neuropathic pain after treatment with anti-EGFR antibodies or tyrosine kinase inhibitors has been previously described. However, few reports have investigated the association of cancer-related nociceptive pain or chronic chemical induced peripheral neuropathy with the analgesic effects of EGFR inhibition. Therefore, we conducted a retrospective survey of 191 patients with colorectal cancer receiving chemotherapy plus molecular targeting drugs to examine the analgesic effects of anti-EGFR antibodies against either cancer pain or oxaliplatin-induced peripheral neuropathy. We identified a significant difference in the improvement rates of nociceptive pain between panitumumab- and bevacizumab-treated patients (100% vs. 9.1%; p < 0.01), but not oxaliplatin-induced peripheral neuropathy. In conclusion, panitumumab may be effective at reducing cancer-related nociceptive pain.
表皮生长因子受体(EGFR)因其缓解疼痛的治疗潜力而受到广泛关注。用抗egfr抗体或酪氨酸激酶抑制剂治疗后神经性疼痛的缓解已有报道。然而，很少有报道调查癌症相关的痛觉性疼痛或慢性化学诱导的周围神经病变与EGFR抑制的镇痛作用的关系。因此，我们对191例接受化疗加分子靶向药物的结直肠癌患者进行了回顾性调查，以研究抗egfr抗体对癌性疼痛或奥沙利铂诱导的周围神经病变的镇痛作用。我们发现帕尼单抗和贝伐单抗治疗的患者在痛觉性疼痛的改善率上存在显著差异(100% vs 9.1%;P < 0.01)，但奥沙利铂诱导的周围神经病变不存在。总之，帕尼珠单抗可能有效减少癌症相关的痛觉性疼痛。
{"title":"Retrospective Evaluation of the Analgesic Effects of Molecular Target Agents Against Cancer Pain and Oxaliplatin-Induced Chronic Peripheral Neuropathy","authors":"S. Yuasa, Megumi Kabeya, S. Hibi, Y. Shirokawa, Chiaki Tokoro, R. Furuta, S. Nagao, S. Kayukawa, Yoshiteru Tanaka, K. Ina","doi":"10.30683/1927-7229.2022.11.06","DOIUrl":"https://doi.org/10.30683/1927-7229.2022.11.06","url":null,"abstract":"Epidermal growth factor receptor (EGFR) has received significant attention for its therapeutic potential for pain relief. The relief of neuropathic pain after treatment with anti-EGFR antibodies or tyrosine kinase inhibitors has been previously described. However, few reports have investigated the association of cancer-related nociceptive pain or chronic chemical induced peripheral neuropathy with the analgesic effects of EGFR inhibition. \u0000Therefore, we conducted a retrospective survey of 191 patients with colorectal cancer receiving chemotherapy plus molecular targeting drugs to examine the analgesic effects of anti-EGFR antibodies against either cancer pain or oxaliplatin-induced peripheral neuropathy. We identified a significant difference in the improvement rates of nociceptive pain between panitumumab- and bevacizumab-treated patients (100% vs. 9.1%; p < 0.01), but not oxaliplatin-induced peripheral neuropathy. \u0000In conclusion, panitumumab may be effective at reducing cancer-related nociceptive pain.","PeriodicalId":14957,"journal":{"name":"Journal of Analytical Oncology","volume":"84 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91459885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-28DOI: 10.30683/1927-7229.2022.11.05
D. Tzerkovsky, A. Mazurenko, D. I. Kozlovsky, F.F. Borychevsky
The aim of this study was to investigate the antitumor efficacy of radiodynamic therapy (RDT) with a chlorin-based photosensitizer (PS) in an in vivo experiment. Material and Methods: The study was performed in 35 white outbred rats weighing 180±30 g. Subcutaneously transplanted Pliss lymphosarcoma (PLS) was used as tumor model. Chlorin-based PS «Photolon» (RUE «Belmedpreparaty», Republic Belarus) was injected intravenously at a dose of 2.5 mg/kg. The radiation therapy sessions (RT) were carried out once 2.5–3 hours after the administration of the PS by the contact method on the device «microSelectron-HDR V3 Digital» (Elekta, Sweden) using γ-radiation (192Ir) in single focal doses (SFD) 2, 4 and 6 Gy. All laboratory animals were subdivided into 7 groups of 5 animals each: intact control, RT 2 Gy, RT 4 Gy, RT 6 Gy, PS + RT 2 Gy, PS + RT 4 Gy and PS + RT 6 Gy. The antitumor effectiveness of exposure was evaluated according to the indicators characterizing the dynamics of volume changes: Vav. (cm3), the coefficient of absolute tumor growth (K, units) and the coefficient of tumor growth inhibition (TGI, %). The frequency of complete regressions (СR) was estimated 60 days after the performed exposures. In each group, the share of animals (%) with no visual and palpatory signs of tumor growth was evaluated. The differences were considered statistically significant at the significance level of p<0.05. Results: On the 16th day from the beginning of the experiment Vav. in groups were 39.07±4.19; 23.06±3.25 (р=0.012); 35.04±2.35 (р=0.419); 25.83±3.06 (р=0.027); 28.36±3.45 (0.074); 25.47±1.88 (р=0.013) and 16.56±3.64 cm3 (р=0,002), respectively. The K coefficients in the experimental groups were 1219.94; 657.86; 1296.78; 716.50; 833.12; 669.26 and 590.43 units, respectively. The TGI coefficients in the experimental groups were 40.98%; 10.31%; 33.89%; 27.41%; 34.81% and 57.61%, respectively. The frequency of complete tumor regressions 60 days after the start of the experiment was 0%, 20%, 0%, 0%, 0%, 0% and 40%, respectively. Conclusion: RDT is a recent extension of conventional photodynamic therapy, in which visible/near infrared light irradiation is replaced by a well-tolerated dose of X-rays. Systemic administration of chlorin-based PS before the RT session increases the antitumor efficacy of RT in animals with PLS transplantable tumors. The data obtained indicate that further studies of the radiosensitizing properties of PS are promising.
{"title":"Radiodynamic Therapy with Chlorine-Based Photosensitizer on Pliss Lymphosarcoma Solid Tumor: In Vivo Experiment","authors":"D. Tzerkovsky, A. Mazurenko, D. I. Kozlovsky, F.F. Borychevsky","doi":"10.30683/1927-7229.2022.11.05","DOIUrl":"https://doi.org/10.30683/1927-7229.2022.11.05","url":null,"abstract":"The aim of this study was to investigate the antitumor efficacy of radiodynamic therapy (RDT) with a chlorin-based photosensitizer (PS) in an in vivo experiment. \u0000Material and Methods: The study was performed in 35 white outbred rats weighing 180±30 g. Subcutaneously transplanted Pliss lymphosarcoma (PLS) was used as tumor model. Chlorin-based PS «Photolon» (RUE «Belmedpreparaty», Republic Belarus) was injected intravenously at a dose of 2.5 mg/kg. The radiation therapy sessions (RT) were carried out once 2.5–3 hours after the administration of the PS by the contact method on the device «microSelectron-HDR V3 Digital» (Elekta, Sweden) using γ-radiation (192Ir) in single focal doses (SFD) 2, 4 and 6 Gy. All laboratory animals were subdivided into 7 groups of 5 animals each: intact control, RT 2 Gy, RT 4 Gy, RT 6 Gy, PS + RT 2 Gy, PS + RT 4 Gy and PS + RT 6 Gy. The antitumor effectiveness of exposure was evaluated according to the indicators characterizing the dynamics of volume changes: Vav. (cm3), the coefficient of absolute tumor growth (K, units) and the coefficient of tumor growth inhibition (TGI, %). The frequency of complete regressions (СR) was estimated 60 days after the performed exposures. In each group, the share of animals (%) with no visual and palpatory signs of tumor growth was evaluated. The differences were considered statistically significant at the significance level of p<0.05. \u0000Results: On the 16th day from the beginning of the experiment Vav. in groups were 39.07±4.19; 23.06±3.25 (р=0.012); 35.04±2.35 (р=0.419); 25.83±3.06 (р=0.027); 28.36±3.45 (0.074); 25.47±1.88 (р=0.013) and 16.56±3.64 cm3 (р=0,002), respectively. The K coefficients in the experimental groups were 1219.94; 657.86; 1296.78; 716.50; 833.12; 669.26 and 590.43 units, respectively. The TGI coefficients in the experimental groups were 40.98%; 10.31%; 33.89%; 27.41%; 34.81% and 57.61%, respectively. The frequency of complete tumor regressions 60 days after the start of the experiment was 0%, 20%, 0%, 0%, 0%, 0% and 40%, respectively. \u0000Conclusion: RDT is a recent extension of conventional photodynamic therapy, in which visible/near infrared light irradiation is replaced by a well-tolerated dose of X-rays. Systemic administration of chlorin-based PS before the RT session increases the antitumor efficacy of RT in animals with PLS transplantable tumors. The data obtained indicate that further studies of the radiosensitizing properties of PS are promising.","PeriodicalId":14957,"journal":{"name":"Journal of Analytical Oncology","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76201384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To analyze the clinical features of de novo lung neuroendocrine tumor (NET) after liver transplantation (LT) for hepatocellular carcinoma (HCC). Method: Retrospectively reviewed the clinical data of the 1253 patients who underwent LT from 2013 to 2022 in our institute. Result: Out of 1253 recipients of LT 7 patients suffered de novo lung carcinoma, of these 2 patients suffered lung NET accounting for 28.6% (2/7) of de novo lung carcinoma both at extensive stage. New on-set lung lesions and hilar and mediastinal lymphadenopathy were found by imaging tests; and were diagnosed as lung NETs in both patients through pathological examination. The interval between LT and diagnosis of lung NET ranged from 5.9 to 44.7 months. Both patients received cisplatin and etoposide as first-line chemotherapy and achieved partial remission. The progression-free survival period ranged from 1.9 to 2.2 months. Survival after diagnosis of lung NET ranged from 7.0 to 10.9 months. One of the patients tried to cease immunosuppressants during chemotherapy and incurred graft rejection. Conclusion: Lung NET may have a higher proportional incidence of de novo lung carcinoma in LT recipients. Early diagnosis is vital for the treatment of lung NET, while predictive and timely biopsy based on imaging findings is crucial for making an early diagnosis.
{"title":"Clinical Features of de Novo Lung Neuroendocrine Tumor after Liver Transplantation for Hepatocellular Carcinoma","authors":"Jianwen Lin, Jiali Yang, Jianjun Lu, Xiaoyi Hao, Jiawei Liu, Huali Yan, Huayi Li, Yu Guo, Yong Gu, Quanyong Cheng","doi":"10.30683/1927-7229.2022.11.04","DOIUrl":"https://doi.org/10.30683/1927-7229.2022.11.04","url":null,"abstract":"Objective: To analyze the clinical features of de novo lung neuroendocrine tumor (NET) after liver transplantation (LT) for hepatocellular carcinoma (HCC). \u0000Method: Retrospectively reviewed the clinical data of the 1253 patients who underwent LT from 2013 to 2022 in our institute. \u0000Result: Out of 1253 recipients of LT 7 patients suffered de novo lung carcinoma, of these 2 patients suffered lung NET accounting for 28.6% (2/7) of de novo lung carcinoma both at extensive stage. New on-set lung lesions and hilar and mediastinal lymphadenopathy were found by imaging tests; and were diagnosed as lung NETs in both patients through pathological examination. The interval between LT and diagnosis of lung NET ranged from 5.9 to 44.7 months. Both patients received cisplatin and etoposide as first-line chemotherapy and achieved partial remission. The progression-free survival period ranged from 1.9 to 2.2 months. Survival after diagnosis of lung NET ranged from 7.0 to 10.9 months. One of the patients tried to cease immunosuppressants during chemotherapy and incurred graft rejection. \u0000Conclusion: Lung NET may have a higher proportional incidence of de novo lung carcinoma in LT recipients. Early diagnosis is vital for the treatment of lung NET, while predictive and timely biopsy based on imaging findings is crucial for making an early diagnosis.","PeriodicalId":14957,"journal":{"name":"Journal of Analytical Oncology","volume":"63 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80184289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-22DOI: 10.30683/1927-7229.2022.11.02
B. Depboylu, N. Ozturk, B. Niğdelioğlu, G. Discigil
Background: It is well known that oncologic management of elderly patients is complicated, and physicians should well define the ultimate goals when choosing treatment modalities. Cancer treatment should not necessarily focus on survival but aim for a good quality of life for the patient in light of their frailty. Patients and Methods: This is a retrospective cross-sectional survey study. One hundred fifty-eight women with breast cancer participated in this study. The PRISMA-7 Frailty Index and WHOQOL-OLD Module assessed participants’ frailty and quality of life. SPSS 26.0 and Medcalc 14 [Acacialaan 22, B-8400 Ostend, Belgium] programs were used for statistical analyses. Statistically significant associations between the PRISMA-7 scale and the WHOQOL-OLD Module were assessed. Results: Of the158 participants, the median age [min-max] was 71 [65-96] years, and 61.2% had stage I and II breast cancer. Lumpectomy was 61.1%, and 75% received chemotherapy-radiotherapy and hormone therapy. For the WHOQOL-OLD domains; financial status [p=0.001] with the sensory ability domain, work status [p<0.001] and education status[p=0.004] with the autonomy domain, education status [p=0.002] with PPF activity domain, education status [p=0.001] and work status [p=0.007] with the social participation domain, treatment modality [p=0.003] with death &dying domain, number of comorbidities [p=0.004] with intimacy domain statistically significant. The total score was associated with education status [p=0.005] and the number of comorbidities [p=0.010]. Frailty correlated positively with age [cut-off age 68 years; p<0.001]. Education status was inversely associated with increased frailty [p=0.003]. The relationship between the PRISMA-7 scale and the WHOQOL-OLD Module correlated negatively in five out of six dimensions except for the Intimacy domain. Conclusions: It is necessary to design customized cancer management programs to improve specific components of elderly women with breast cancer with increased frailty by revealing the associations in domains of QoL.
{"title":"The Relationships between Frailty and Quality of Life in Elderly Women with Breast Cancer","authors":"B. Depboylu, N. Ozturk, B. Niğdelioğlu, G. Discigil","doi":"10.30683/1927-7229.2022.11.02","DOIUrl":"https://doi.org/10.30683/1927-7229.2022.11.02","url":null,"abstract":"Background: It is well known that oncologic management of elderly patients is complicated, and physicians should well define the ultimate goals when choosing treatment modalities. Cancer treatment should not necessarily focus on survival but aim for a good quality of life for the patient in light of their frailty. \u0000Patients and Methods: This is a retrospective cross-sectional survey study. One hundred fifty-eight women with breast cancer participated in this study. The PRISMA-7 Frailty Index and WHOQOL-OLD Module assessed participants’ frailty and quality of life. SPSS 26.0 and Medcalc 14 [Acacialaan 22, B-8400 Ostend, Belgium] programs were used for statistical analyses. Statistically significant associations between the PRISMA-7 scale and the WHOQOL-OLD Module were assessed. \u0000Results: Of the158 participants, the median age [min-max] was 71 [65-96] years, and 61.2% had stage I and II breast cancer. Lumpectomy was 61.1%, and 75% received chemotherapy-radiotherapy and hormone therapy. For the WHOQOL-OLD domains; financial status [p=0.001] with the sensory ability domain, work status [p<0.001] and education status[p=0.004] with the autonomy domain, education status [p=0.002] with PPF activity domain, education status [p=0.001] and work status [p=0.007] with the social participation domain, treatment modality [p=0.003] with death &dying domain, number of comorbidities [p=0.004] with intimacy domain statistically significant. The total score was associated with education status [p=0.005] and the number of comorbidities [p=0.010]. Frailty correlated positively with age [cut-off age 68 years; p<0.001]. Education status was inversely associated with increased frailty [p=0.003]. The relationship between the PRISMA-7 scale and the WHOQOL-OLD Module correlated negatively in five out of six dimensions except for the Intimacy domain. \u0000Conclusions: It is necessary to design customized cancer management programs to improve specific components of elderly women with breast cancer with increased frailty by revealing the associations in domains of QoL.","PeriodicalId":14957,"journal":{"name":"Journal of Analytical Oncology","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81858845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：