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Guedel's Airway for Awake LMA Extubation: An Innovative Technique Guedel气道清醒LMA拔管:一种创新技术
Pub Date : 2018-01-01 DOI: 10.4172/2155-6148.1000852
Deepti Ahuja, G. Gupta, N. Gupta, S. Bharti
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引用次数: 0
Effect of Selective COX-2 Inhibitor on IL-1β and Glasgow Coma Scale (GCS) Score in Moderate Traumatic Brain Injury Patients 选择性COX-2抑制剂对中度颅脑损伤患者IL-1β和格拉斯哥昏迷评分的影响
Pub Date : 2018-01-01 DOI: 10.4172/2155-6148.1000855
D. Bisri, Z. Arifin, I. S. Redjeki, T. Bisri
Glasglow Coma Scale (GCS) is the most frequently used clinical scoring for traumatic brain injury patients. The lower the GCS score is, the higher the morbidity and mortality. Neuroinflammation is one of the mechanisms of secondary brain injury. Selective cyclooxygenase (sCOX-2) inhibitors are drugs commonly used in postoperative pain which also possesses an anti-inflammatory effect. The aim of this study is to determine the role of sCOX-2 inhibitors as inflammatory process inhibitor in patients with head injury through the measurement of IL-1β and GCS score. This is a double blind randomized controlled study involving patients with moderate head injuries who underwent surgery in Dr. Hasan Sadikin General Hospital Bandung Indonesia from December 2013 to December 2015. After obtaining approval from the Research Ethics Committee of the Faculty of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, samples were divided randomly into 5 groups consisting of 6 patients: control group, COX2-group I (with a single dose of sCOX-2 inhibitor), COX2-group II (with two separate doses of sCOX-2 inhibitor), COX2-group III (with three separate doses of sCOX-2 inhibitor), and COX2-group IV (with four separate doses of sCOX-2 inhibitor four times). All patients received a standard therapy as recommended by the Traumatic Brain Foundation in 2007 as well as having their GCS, blood pressure, pulse rate, respiratory rate, oxygen saturation, temperature and blood sugar monitored preand post-operatively. Data were then analyzed using Paired Sample T-test and One-Way Anova statistical tests with a p-value of <0.05 considered as statistically significant. Results showed that there was a very significant improvement in GCS score in COX2-group II, III, IV with p values of 0.003, 0.002, and 0.001, respectively. No significant difference was found in IL-1β between COX2-1, COX2-II, COX2-III and control group (p<0.05), but IL-1β increased significantly in group COX2-IV (p=0.043). It is concluded that sCOX-2 inhibitor has a brain protective effect by improving the GCS score in patients with moderate head injury.
Glasglow昏迷量表(GCS)是外伤性脑损伤患者最常用的临床评分方法。GCS评分越低,发病率和死亡率越高。神经炎症是继发性脑损伤的机制之一。选择性环氧合酶(sCOX-2)抑制剂是治疗术后疼痛的常用药物,也具有抗炎作用。本研究的目的是通过测量IL-1β和GCS评分来确定sCOX-2抑制剂作为炎症过程抑制剂在颅脑损伤患者中的作用。这是一项双盲随机对照研究,涉及2013年12月至2015年12月在印度尼西亚万隆哈桑·萨迪金医生总医院接受手术的中度头部损伤患者。在获得Padjadjaran大学医学院研究伦理委员会的批准后。将样本随机分为5组,每组6例患者:对照组、cox - 1组(单剂量使用sCOX-2抑制剂)、cox -2组(2次单独使用sCOX-2抑制剂)、cox - 3组(3次单独使用sCOX-2抑制剂)、cox - 4组(4次单独使用sCOX-2抑制剂)。所有患者均接受创伤性脑基金会2007年推荐的标准治疗,并在术前和术后监测GCS、血压、脉搏率、呼吸率、血氧饱和度、体温和血糖。数据分析采用配对样本t检验和单因素方差分析统计检验,p值<0.05认为有统计学意义。结果显示,cox2组II、III、IV组GCS评分有非常显著的改善,p值分别为0.003、0.002、0.001。COX2-1、COX2-II、COX2-III组血清IL-1β水平与对照组比较差异无统计学意义(p<0.05),但COX2-IV组血清IL-1β水平显著升高(p=0.043)。由此可见,sCOX-2抑制剂通过提高中度颅脑损伤患者的GCS评分具有脑保护作用。
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引用次数: 0
Comparision of Intubating Conditions at 60 Seconds with Different Doses of Rocuronium Using the Timing Principle 不同剂量罗库溴铵60秒插管情况的定时比较
Pub Date : 2018-01-01 DOI: 10.4172/2155-6148.1000815
Arun Kumar, S. Suchetha
Objective: To evaluate the intubating conditions with rocuronium at 0.6 mg/kg (2*ED 95) and 0.9 mg/kg (3*ED 95) at 60 s using the timing principle. Methods: 60 patients were divided into 2 groups of 30 each. Group A received 0.9 mg/kg and group B received 0.6 mg/kg of rocuronium. Intubation was done at 60 s. The Train of four monitoring was done at the adductor pollicis muscle. The TOF count at intubation and time to loss of TOF were noted and compared. Results: Intubating conditions were excellent 13 (65%) in group A compared to 9 (45%) in group B. The TOF count at intubation was not statistically significant (p=0.677) between the groups whereas time to loss of TOF (p=0.03) were significant between the groups. Conclusion: Clinically acceptable intubating conditions were found in both groups but the conditions were better with group A in comparision with group B.
目的:应用定时原则评价0.6 mg/kg (2*ED 95)和0.9 mg/kg (3*ED 95) 60s罗库溴铵的插管情况。方法:60例患者分为2组,每组30例。A组给予0.9 mg/kg, B组给予0.6 mg/kg罗库溴铵。60秒插管。在政策内收肌处进行四组监测。记录并比较插管时TOF计数和TOF消失的时间。结果:插管条件良好,A组13例(65%),b组9例(45%),插管时TOF计数组间差异无统计学意义(p=0.677), TOF消失时间组间差异有统计学意义(p=0.03)。结论:两组患者均有临床可接受的插管条件,但A组插管条件优于B组。
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引用次数: 2
Effect of Different Doses of Dexmedetomidine Combined With Desflurane on Recovery of Protective Airway Reflexes 不同剂量右美托咪定联合地氟醚对气道保护反射恢复的影响
Pub Date : 2018-01-01 DOI: 10.4172/2155-6148.1000862
Yue Yin
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引用次数: 0
The Predictive Values of Anatomical Parameters for Difficult Mask Ventilation in Patients who Underwent Elective Surgeries in Wolaita Sodo Town Hospitals, 2017 2017年Wolaita Sodo镇医院择期手术患者困难面罩通气解剖参数的预测价值
Pub Date : 2018-01-01 DOI: 10.4172/2155-6148.1000868
K. Hailegebriel, A. Tolera, T. Marama
Background: Mask ventilation is the primary technique of ventilation before insertion of any airway device. Difficulties in mask ventilation have been associated with serious complications, such as death or hypoxic brain damage. If the anesthetist can predict which patients are likely to prove difficult to ventilate, he/she may reduce the risks of anesthesia considerably. The study was aimed to assess the incidence of and predictive values of anatomical parameters for difficult mask ventilation among patients who underwent elective surgeries at Wolaita Sodo University teaching and referral Hospital and Sodo Christian Hospital. Methods: Institutional based cross sectional study was conducted from July 1 to August 30, 2017 in two hospitals of wolaita zone. The study was conducted on 278 patients of which 101 (36.3%) were males and 177 (63.7%) were females. Patient demographics, incidence and predictive values of anatomical parameters for difficult mask ventilation were studied among elective patients who took general anesthesia. Result: The incidence of difficult mask ventilation (grade III) was 2.2%; whereas, impossible mask ventilation (grade IV) was 0.4%. Highest percent of difficult mask ventilation (grade III) was occurred in patients with obstructive sleep apnea, BMI˃26 kg/m2 and Mandibular Protrusion Class C. Conclusion: Modified Mallampatti class III and IV and Mandibular protrusion class B and C are highly accurate parameters with high specificity, negative predictive value and positive predictive value to predict difficult mask ventilation.
背景:面罩通气是任何气道设备插入前的主要通气技术。口罩通气困难与严重并发症有关,如死亡或缺氧性脑损伤。如果麻醉师能够预测哪些患者可能难以通气,他/她就可以大大降低麻醉的风险。本研究旨在评估在Wolaita Sodo大学教学和转诊医院和Sodo基督教医院接受择期手术的患者中困难面罩通气的解剖学参数的发生率和预测价值。方法:于2017年7月1日至8月30日在沃莱塔地区两家医院进行基于机构的横断面研究。研究对象278例,其中男性101例(36.3%),女性177例(63.7%)。研究择期全麻患者的患者人口统计学特征、困难面罩通气的发生率及解剖学参数的预测值。结果:口罩通气困难(III级)发生率为2.2%;而不可能的口罩通气(IV级)为0.4%。阻塞性睡眠呼吸暂停患者面罩困难通气(III级)的比例最高,BMI指数为26 kg/m2,下颌突出为C级。结论:改良Mallampatti III级和IV级以及下颌突出为B级和C级,是预测面罩困难通气的高特异性、阴性预测值和阳性预测值的高精度参数。
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引用次数: 1
A Case of Airway Management for Endotracheal Tumor Resection 气管内肿瘤切除术的气道管理1例
Pub Date : 2018-01-01 DOI: 10.4172/2155-6148.1000839
Ye Wang, Zhenggang Guo
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引用次数: 1
The Effectiveness of Standard Single Dose Omeprazole vs. High Dose Continuous Infusion in High-risk Critically Ill Patients 标准单剂量奥美拉唑与大剂量持续输注在高危危重患者中的疗效比较
Pub Date : 2018-01-01 DOI: 10.4172/2155-6148.1000819
E. Ibrahim, Hala M Koptan
Objectives: The present study was carried out to investigate the beneficial effects of high dose omeprazole versus standard low dose as a prophylaxis against upper GIT bleeding in high risk critically ill patients. Methods: A hundred and ten high risk critically ill patients were divided into two groups, fifty-five patients each. Group A received intravenous (IV) omeprazole 40 mg bolus dose once daily followed by normal saline infusion. Group B received IV bolus of 80 mg omeprazole followed by 8 mg/h infusion. The treatment was for the whole period of ICU stay. Early morning gastric pH, residual gastric volume, signs of significant upper GIT bleeding, ICU stay Hb, number of ICU days without ventilator, ICU stay hemoglobin (Hb), number of red cell units transfused in ICU, ICU stay, and numbers of ICU survivors were recorded. Results: Gastric pH was higher in group B compared to group A (p<0.05). The number of patients developed significant upper GIT bleeding were significantly higher in group A. Group A had lower ICU Hb levels and used significant higher number of RBC units. ICU stay was significantly higher in group A compared to group B (p=0.02). There were no statistical differences regarding the number of ICU days without ventilator and ICU survivors between both groups (P<0.05). Conclusions: High dose PPI continuous infusion can reduce the incidence of upper GIT bleeding in high risk critically ill patients. High dose PPI can reduce ICU stay with no effect on ICU survivor rate.
目的:本研究旨在探讨高剂量奥美拉唑与标准低剂量奥美拉唑预防高危危重患者上消化道出血的有益效果。方法:110例危重高危患者随机分为两组,每组55例。A组患者静脉滴注奥美拉唑40 mg,每日1次,同时滴注生理盐水。B组患者静脉滴注奥美拉唑80 mg,随后静脉滴注8 mg/h。治疗为ICU全期治疗。记录清晨胃pH值、胃残量、上消化道明显出血迹象、ICU住院日Hb、不使用呼吸机天数、ICU住院日血红蛋白(Hb)、ICU输注红细胞数、ICU住院日、ICU存活人数。结果:B组胃pH值高于A组(p<0.05)。A组发生显著上消化道出血的患者数量显著高于A组,A组ICU Hb水平较低,RBC单位数显著高于A组。A组ICU住院时间明显高于B组(p=0.02)。两组患者无呼吸机ICU天数及ICU存活时间比较,差异均无统计学意义(P<0.05)。结论:大剂量PPI持续输注可降低高危危重患者胃肠道上段出血的发生率。大剂量PPI可缩短ICU住院时间,但对ICU生存率无影响。
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引用次数: 1
Comparison of Invasive vs. Noninvasive CVP Monitoring in Patients Undergoing Major Intra-Abdominal Surgery: A Prospective Comparative Pilot Study 大腹内手术患者有创与无创CVP监测的比较:一项前瞻性比较先导研究
Pub Date : 2018-01-01 DOI: 10.4172/2155-6148.1000866
I. Gratz, Vinay Kudur, Francis Spitz, S. Jean, I. Allen, Julia E. Seaman, E. Deal
Background: The primary objective of the study was to compare central venous pressure (CVP) measured invasively to one measured non-invasively (NICVP) by monitoring upper arm blood flow changes in response to externally applied circumferential pressure to the upper arm veins. Methods: The NICVP monitor (NeuMeDx®) employs impedance plethysmography using 4 electrodes and a blood pressure cuff to determine a person's CVP. Three invasively measured CVP pressure measurements were compared to the NICVP taken during the same time period after induction of anesthesia in 29 patients. Results: Data from both methods were normally distributed and, in paired tests, were not significantly different (p=0.255). Over 95% of the values were within 3.0 mmHg of each other, the threshold estimate for clinical equivalence. The two measurements were highly correlated (r=0.657) and a Bland-Altman analysis showed good agreement. Conclusions: The non-invasive device was accurate and able to mirror the invasive CVP in our study population. Trial registration: #03705299, Clinical trials.gov
背景:本研究的主要目的是通过监测上臂血流变化对上臂静脉外周压的响应,比较有创测量的中心静脉压(CVP)和无创测量(NICVP)。方法:NICVP监护仪(NeuMeDx®)采用阻抗容积描记术,使用4个电极和一个血压袖带来测定患者的CVP。将29例患者在麻醉诱导后同一时间段内的三次有创测量CVP压力与NICVP进行比较。结果:两种方法的数据均呈正态分布,在配对检验中,差异无统计学意义(p=0.255)。超过95%的数值相差在3.0 mmHg以内,这是临床等效的阈值估计。这两个测量值高度相关(r=0.657), Bland-Altman分析显示出良好的一致性。结论:在我们的研究人群中,无创装置是准确的,能够反映有创CVP。试验注册:03705299,Clinical trials.gov
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引用次数: 0
Flexible Fiberoptic Intubation in Difficult Airway: A Retrospective Evaluation in a Portuguese University Hospital 柔性纤维插管在困难气道:回顾性评价在葡萄牙大学医院
Pub Date : 2018-01-01 DOI: 10.4172/2155-6148.1000844
C. Miranda, C. Mexêdo, C. Cavaleiro, H. Machado
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引用次数: 0
Epidural Catheter Fixation and Care-A Novel Technique 硬膜外导管固定与护理——一种新技术
Pub Date : 2018-01-01 DOI: 10.4172/2155-6148.1000832
Wasimul Hoda, Priodarshi Roychoudhury, Abhishek Kumar, S. Bharti
A lot of emphasis is put on the technique of epidural insertion but however technique of catheter fixation is often neglected [2]. Ideally, the fixation method should be safe, non-invasive and cost-effective and maintain the sterility of the catheter. Correct catheter fixation goes a long way in preventing catheter migration and infection which ensures a safe epidural analgesia without complications [2].
硬膜外置管技术被大量重视,而导管固定技术却经常被忽视[2]。理想情况下,固定方法应安全、无创、经济有效,并保持导管的无菌性。正确的导管固定在防止导管移位和感染方面有很大的作用,可以确保安全无并发症的硬膜外镇痛[2]。
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引用次数: 0
期刊
Journal of Anesthesia and Clinical Research
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