Pub Date : 2023-03-14DOI: 10.31487/j.acr.2023.01.01
E. Samara, S. Siminelakis, A. Karakosta, P. Tzimas
{"title":"Pulmonary Artery Catheter Sutured on the Pulmonary Trunk and Relevant Clinical Consequences","authors":"E. Samara, S. Siminelakis, A. Karakosta, P. Tzimas","doi":"10.31487/j.acr.2023.01.01","DOIUrl":"https://doi.org/10.31487/j.acr.2023.01.01","url":null,"abstract":"<jats:p />","PeriodicalId":15000,"journal":{"name":"Journal of Anesthesia and Clinical Research","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84204524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-13DOI: 10.31487/j.acr.2022.04.01
Sistac Ballarín JM, Lliteras M, Sistac Palacin JM
Introduction: Empowerment of simulations in emergent situations by resident medical interns has positively demonstrated the acquisition of clinical skills [1]. Even so, it remains unclear what psychological factors influence when assuming leadership in carrying out these simulations or in a real situation. This study aims to analyse, by simulating critical situations in the operating room, the influence of training and personality among anaesthesiology residents on the predisposition to assume such leadership. Materials and Methods: A study was carried out on 22 residents both trained (11) and untrained in simulation, assessing their personality and degree of stress using the Typi and Stay Trait. By observation it was determined that he was the leader, when entering a simulated model of ventricular fibrillation in pairs. Resolution capacity was not valued, but rather the characteristics that define the personality of the resident who assumed leadership. Results: Regarding personality, measured with the TIPI test, the leaders turned out to score high in agreeableness but low in extraversion compared to the helpers. This suggests that they are altruistic, compassionate, trusting, frank, empathic and sensitive to others and on the other hand reserved, socially distant except with close friends. In the trained group, the Stai Trait test revealed a slightly lower mean in helpers compared to the total mean, in addition to a significantly higher SD in leaders (4.57) than in helpers (2.87), obtaining a p> 0.02. In Stai Estado, the opposite occurred in terms of the averages, lower in the group of leaders with respect to the global average. And a very similar SD was obtained in both groups (4.91 and 4.21). In the TIPI test, the leading group stands out with a low score in extraversion, compared to the total mean and compared to assistants, justified data with a p>0.02. Conclusion: The residents of the trained group turned out to have lower anxiety in the stressful situation of the simulation compared to the other group. In addition, the women who turned out to be leaders in the trained group demonstrated control of the situation with lower HRs than the leaders in the untrained group, thus demonstrating the influence of training in resolving critical situations.
{"title":"Study in a Simulated Scenario of the Influence of Training and Personality in the Resolution of Critical Situations in Anaesthesiology Residents","authors":"Sistac Ballarín JM, Lliteras M, Sistac Palacin JM","doi":"10.31487/j.acr.2022.04.01","DOIUrl":"https://doi.org/10.31487/j.acr.2022.04.01","url":null,"abstract":"Introduction: Empowerment of simulations in emergent situations by resident medical interns has positively demonstrated the acquisition of clinical skills [1]. Even so, it remains unclear what psychological factors influence when assuming leadership in carrying out these simulations or in a real situation. This study aims to analyse, by simulating critical situations in the operating room, the influence of training and personality among anaesthesiology residents on the predisposition to assume such leadership.\u0000Materials and Methods: A study was carried out on 22 residents both trained (11) and untrained in simulation, assessing their personality and degree of stress using the Typi and Stay Trait. By observation it was determined that he was the leader, when entering a simulated model of ventricular fibrillation in pairs. Resolution capacity was not valued, but rather the characteristics that define the personality of the resident who assumed leadership.\u0000Results: Regarding personality, measured with the TIPI test, the leaders turned out to score high in agreeableness but low in extraversion compared to the helpers. This suggests that they are altruistic, compassionate, trusting, frank, empathic and sensitive to others and on the other hand reserved, socially distant except with close friends. In the trained group, the Stai Trait test revealed a slightly lower mean in helpers compared to the total mean, in addition to a significantly higher SD in leaders (4.57) than in helpers (2.87), obtaining a p> 0.02. In Stai Estado, the opposite occurred in terms of the averages, lower in the group of leaders with respect to the global average. And a very similar SD was obtained in both groups (4.91 and 4.21). In the TIPI test, the leading group stands out with a low score in extraversion, compared to the total mean and compared to assistants, justified data with a p>0.02.\u0000Conclusion: The residents of the trained group turned out to have lower anxiety in the stressful situation of the simulation compared to the other group. In addition, the women who turned out to be leaders in the trained group demonstrated control of the situation with lower HRs than the leaders in the untrained group, thus demonstrating the influence of training in resolving critical situations.","PeriodicalId":15000,"journal":{"name":"Journal of Anesthesia and Clinical Research","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80423740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-17DOI: 10.31487/j.acr.2022.03.04
Nicole Greeff, R. Davids
Thrombosis is often seen in acute respiratory distress syndrome (ARDS) patients, increasing morbidity and mortality. This review highlights the pathophysiology of ARDS and how it links to pulmonary thrombosis. Understanding this link is furthermore critical as pulmonary thrombosis a serious issue in coronavirus diseases, such as COVID-19. There is a clear link between ARDS pathophysiology and pulmonary thrombosis as defined by the “two-path unifying theory” and “two-activation theory of the endothelium”. Interestingly, ARDS in influenza versus COVID-19 patients have a slightly different pathophysiology, the latter having more compact fibrin clots that are more difficult to dissolve; this will impact the treatment of COVID-19 ARDS patients. We therefore also reviewed the current treatment options, underlining that potentially life-saving thrombosis-screening procedures could be lacking in resource-limited settings, therefore needing redress.
{"title":"Pulmonary Thrombosis in Acute Respiratory Distress Syndrome: Theory, Evidence, and Clinical Relevance to Resource-Limited Settings","authors":"Nicole Greeff, R. Davids","doi":"10.31487/j.acr.2022.03.04","DOIUrl":"https://doi.org/10.31487/j.acr.2022.03.04","url":null,"abstract":"Thrombosis is often seen in acute respiratory distress syndrome (ARDS) patients, increasing morbidity and mortality. This review highlights the pathophysiology of ARDS and how it links to pulmonary thrombosis. Understanding this link is furthermore critical as pulmonary thrombosis a serious issue in coronavirus diseases, such as COVID-19. There is a clear link between ARDS pathophysiology and pulmonary thrombosis as defined by the “two-path unifying theory” and “two-activation theory of the endothelium”. Interestingly, ARDS in influenza versus COVID-19 patients have a slightly different pathophysiology, the latter having more compact fibrin clots that are more difficult to dissolve; this will impact the treatment of COVID-19 ARDS patients. We therefore also reviewed the current treatment options, underlining that potentially life-saving thrombosis-screening procedures could be lacking in resource-limited settings, therefore needing redress.","PeriodicalId":15000,"journal":{"name":"Journal of Anesthesia and Clinical Research","volume":"112 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85490651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-14DOI: 10.31487/j.acr.2022.03.02
N. Panse, Nikhil Bhoi, Aparajita Pandey, Priyanka Dhananjay Tikait
Background: With the increasing trend of IONM in neurosurgery the role of total intravenous anaesthesia has gained upper hand in the practice of neuro anaesthesia. Propofol based TIVA techniques facilitates rapid recovery of consciousness and psychomotor function with lower incidence of post-operative nausea and vomiting. It also facilitates satisfactory IONM monitoring while maintaining the adequate depth of anaesthesia. Available literature focuses on the surgical aspects with IONM. Few studies are available, which compare TIVA with general anaesthesia that too without IONM. Earlier TIVA for IONM has been studied in patients undergoing kyphoscoliosis correction surgery. This study was conducted to evaluate the efficacy of TIVA in facilitating IONM in resection of intracranial masses and to study its effects on hemodynamics and post op recovery. Methods: In our retrospective study of 23 cases, patients undergoing intracranial tumor mass excision surgeries requiring IONM were given standardized general anaesthesia using intubating dose of short acting muscle relaxant and further maintenance of anaesthesia was done using infusion of propofol and dexmeditomidine with the minimal inhalational agents. IONM was recorded successfully. Results: 18 patients were haemodyanamically stable. 3 patients had intermittent episodes of bradycardia, and 2 patients had hypotension. Three patients elicited dampened response requiring reduction in anaesthetic dose. Six patients exhibited delayed recovery. Conclusion: TIVA with propofol and dexmeditomidine is a good anaesthetic modality to facilitate IONM in resection of intracranial masses.
{"title":"Management of Cerebropontine Angle Tumors on Total Intravenous Anaesthesia Facilitating Neuromuscular Monitoring: A Retrospective Observational Study","authors":"N. Panse, Nikhil Bhoi, Aparajita Pandey, Priyanka Dhananjay Tikait","doi":"10.31487/j.acr.2022.03.02","DOIUrl":"https://doi.org/10.31487/j.acr.2022.03.02","url":null,"abstract":"Background: With the increasing trend of IONM in neurosurgery the role of total intravenous anaesthesia has gained upper hand in the practice of neuro anaesthesia. Propofol based TIVA techniques facilitates rapid recovery of consciousness and psychomotor function with lower incidence of post-operative nausea and vomiting. It also facilitates satisfactory IONM monitoring while maintaining the adequate depth of anaesthesia. Available literature focuses on the surgical aspects with IONM. Few studies are available, which compare TIVA with general anaesthesia that too without IONM. Earlier TIVA for IONM has been studied in patients undergoing kyphoscoliosis correction surgery. This study was conducted to evaluate the efficacy of TIVA in facilitating IONM in resection of intracranial masses and to study its effects on hemodynamics and post op recovery.\u0000Methods: In our retrospective study of 23 cases, patients undergoing intracranial tumor mass excision surgeries requiring IONM were given standardized general anaesthesia using intubating dose of short acting muscle relaxant and further maintenance of anaesthesia was done using infusion of propofol and dexmeditomidine with the minimal inhalational agents. IONM was recorded successfully.\u0000Results: 18 patients were haemodyanamically stable. 3 patients had intermittent episodes of bradycardia, and 2 patients had hypotension. Three patients elicited dampened response requiring reduction in anaesthetic dose. Six patients exhibited delayed recovery.\u0000Conclusion: TIVA with propofol and dexmeditomidine is a good anaesthetic modality to facilitate IONM in resection of intracranial masses.","PeriodicalId":15000,"journal":{"name":"Journal of Anesthesia and Clinical Research","volume":"106 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79291826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-30DOI: 10.31487/j.acr.2022.03.01
N. Panse, J. Deshpande
Clavicle fractures are commonly encountered in orthopedic outpatient department but are often managed conservatively. Yet some clavicle fractures need surgical intervention which in turn demand adequate anaesthesia and analgesia. Due to complex sensory innervation there is no sole regional anaesthesia technique which could provide adequate analgesia for clavicle fractures. With the advent of ultra-sonography (USG) and the description of clavipectoral fascia plane block (CPB) by Dr. Valde a lot was simplified. Administration of CPB provides intra as well as postoperative analgesia, maintains hemodynamics, reduces opioid consumption and improvises postoperative recovery of the patients undergoing clavicle surgeries.
{"title":"Efficacy of Clavipectoral Fascia Plane Block as Analgesic Modality in Clavicle Fractures: Exploring New Horizons","authors":"N. Panse, J. Deshpande","doi":"10.31487/j.acr.2022.03.01","DOIUrl":"https://doi.org/10.31487/j.acr.2022.03.01","url":null,"abstract":"Clavicle fractures are commonly encountered in orthopedic outpatient department but are often managed conservatively. Yet some clavicle fractures need surgical intervention which in turn demand adequate anaesthesia and analgesia. Due to complex sensory innervation there is no sole regional anaesthesia technique which could provide adequate analgesia for clavicle fractures. With the advent of ultra-sonography (USG) and the description of clavipectoral fascia plane block (CPB) by Dr. Valde a lot was simplified. Administration of CPB provides intra as well as postoperative analgesia, maintains hemodynamics, reduces opioid consumption and improvises postoperative recovery of the patients undergoing clavicle surgeries.","PeriodicalId":15000,"journal":{"name":"Journal of Anesthesia and Clinical Research","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80886692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-29DOI: 10.31487/j.acr.2022.02.04
Ray-Ling Hsiao, Yu-Wei Lin, Chiang-Yun Chen
Infrared laser as a heat source could induce gene expression by activating heat promoter genes in Caenorhabditis elegans, as previously reported. In this study, we innovatively used a 266-nm laser to irradiate C. elegans for only one second and observed a significant inhibition of the overall number of eggs laid (P < 0.0001) and the first day egg laying (P=0.005). This is the first study to establish how light with a wavelength of 266-nm can influence a life activity such as laying eggs in C. elegans.
{"title":"Innovative Observation of a 266-nm Laser Inhibiting Egg Laying in Caenorhabditis elegans","authors":"Ray-Ling Hsiao, Yu-Wei Lin, Chiang-Yun Chen","doi":"10.31487/j.acr.2022.02.04","DOIUrl":"https://doi.org/10.31487/j.acr.2022.02.04","url":null,"abstract":"Infrared laser as a heat source could induce gene expression by activating heat promoter genes in Caenorhabditis elegans, as previously reported. In this study, we innovatively used a 266-nm laser to irradiate C. elegans for only one second and observed a significant inhibition of the overall number of eggs laid (P < 0.0001) and the first day egg laying (P=0.005). This is the first study to establish how light with a wavelength of 266-nm can influence a life activity such as laying eggs in C. elegans.","PeriodicalId":15000,"journal":{"name":"Journal of Anesthesia and Clinical Research","volume":"149 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75726004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-26DOI: 10.31487/j.acr.2022.02.03
N. Elshalakany
Background: Caudal block has the potential advantage that, by adding other drugs to the local anaesthetic agent, the duration and effectiveness of the block may be extended. Peripheral nerve blocks and caudal anaesthesia are very benign, nonetheless inordinate attention is compulsory to evade side effects. Aim and objectives: We aimed at this study to compare total postoperative analgesic requirement, anaesthetic, analgesic and sedation qualities. Hemodynamic changes, motor block, adverse effect, and parents’ satisfaction in children who received caudal bupivacaine only versus caudal bupivacaine with ketamine in paediatric patients undergoing surgery below the level of the umbilicus. Methods: Prospective randomized double blind controlled clinical trial conduced at operation room in University Hospital in Faculty of Medicine, October 6 University. Sixty children scheduled for elective surgery below umbilicus were randomly allocated to either: Group A (30 patients) includes the children who take saline caudal bupivacaine with dose of 1 ml/kg, afterward initiation of overall anaesthesia or Group B (30 patients) who following the administration of general anaesthesia, receives caudal bupivacaine 0.25 % in a dose of 1 ml/kg and caudal ketamine preservative free in a dose of 0.5 mg/kg. Hemodynamic alterations, parent satisfaction, postoperative analgesia and sedation characteristics, and side effects were noted. Results: The studied groups showed no statically significant difference regarding demographic data. Motor block statistically was significantly lower in ketamine group. Anaesthesia quality statistically was significantly higher in ketamine group. Regarding hemodynamic state, mean arterial blood pressure (MPA) and heart rate showed a statistically significant difference during and up to 30 minute postoperative (P<0.001), and oxygen saturation showed no statistically significant difference during and after surgery (P>0.05). Sedation score was higher in ketamine group, were lower in ketamine group all were statistically significant. Side effects statistically were non-significantly but less frequent in ketamine group. Total 24-hours analgesia dose statistically was significantly lesser in ketamine group. Parent’s satisfaction statistically was suggestively better in ketamine group. Conclusion: Amalgamation therapy of ketamine with bupivacaine is enhanced decision for post-operative pain controller in children enduring surgery below the umbilical. It increased the duration of analgesia and abridged the necessity for post-operative analgesic supplementation as well.
{"title":"Pediatric Patients Undergoing Elective Surgeries Below the Umbilicus: Comparative Study of Caudal Bupivacaine (0.25%) and Caudal Bupivacaine (0.25%) with Ketamine","authors":"N. Elshalakany","doi":"10.31487/j.acr.2022.02.03","DOIUrl":"https://doi.org/10.31487/j.acr.2022.02.03","url":null,"abstract":"Background: Caudal block has the potential advantage that, by adding other drugs to the local anaesthetic agent, the duration and effectiveness of the block may be extended. Peripheral nerve blocks and caudal anaesthesia are very benign, nonetheless inordinate attention is compulsory to evade side effects.\u0000Aim and objectives: We aimed at this study to compare total postoperative analgesic requirement, anaesthetic, analgesic and sedation qualities. Hemodynamic changes, motor block, adverse effect, and parents’ satisfaction in children who received caudal bupivacaine only versus caudal bupivacaine with ketamine in paediatric patients undergoing surgery below the level of the umbilicus. \u0000Methods: Prospective randomized double blind controlled clinical trial conduced at operation room in University Hospital in Faculty of Medicine, October 6 University. Sixty children scheduled for elective surgery below umbilicus were randomly allocated to either: Group A (30 patients) includes the children who take saline caudal bupivacaine with dose of 1 ml/kg, afterward initiation of overall anaesthesia or Group B (30 patients) who following the administration of general anaesthesia, receives caudal bupivacaine 0.25 % in a dose of 1 ml/kg and caudal ketamine preservative free in a dose of 0.5 mg/kg. Hemodynamic alterations, parent satisfaction, postoperative analgesia and sedation characteristics, and side effects were noted. \u0000Results: The studied groups showed no statically significant difference regarding demographic data. Motor block statistically was significantly lower in ketamine group. Anaesthesia quality statistically was significantly higher in ketamine group. Regarding hemodynamic state, mean arterial blood pressure (MPA) and heart rate showed a statistically significant difference during and up to 30 minute postoperative (P<0.001), and oxygen saturation showed no statistically significant difference during and after surgery (P>0.05). Sedation score was higher in ketamine group, were lower in ketamine group all were statistically significant. Side effects statistically were non-significantly but less frequent in ketamine group. Total 24-hours analgesia dose statistically was significantly lesser in ketamine group. Parent’s satisfaction statistically was suggestively better in ketamine group.\u0000Conclusion: Amalgamation therapy of ketamine with bupivacaine is enhanced decision for post-operative pain controller in children enduring surgery below the umbilical. It increased the duration of analgesia and abridged the necessity for post-operative analgesic supplementation as well.","PeriodicalId":15000,"journal":{"name":"Journal of Anesthesia and Clinical Research","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75890190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-14DOI: 10.31487/j.acr.2022.02.02
Ryan Erskine, K. Collins, L. Mcdonald
{"title":"Tailored Routine Sugammadex Reversal is More Cost-Effective Than Neostigmine: A Narrative Review","authors":"Ryan Erskine, K. Collins, L. Mcdonald","doi":"10.31487/j.acr.2022.02.02","DOIUrl":"https://doi.org/10.31487/j.acr.2022.02.02","url":null,"abstract":"<jats:p />","PeriodicalId":15000,"journal":{"name":"Journal of Anesthesia and Clinical Research","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81508846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-28DOI: 10.31487/j.acr.2022.01.03
C. Oguntoye, Abayomi Kayode Olaifa, Faith Ifeoluwa Adewale
Haematobiochemical responses following epidural administration of ropivacaine to West African Dwarf (WAD) goats were studied. Complete analgesia of the flank, abdomen and hindlimbs was achieved in all the goats. Transient non- significant (p > 0.05) increase in haematocrit and neutrophil values and a transient lymphocytopaenia were observed at 1 hour post epidural drug administration. There was also a transient non- significant increase (p > 0.05) in RBC, haemoglobin, WBC but decrease platelets at 1 hour post epidural drug administration. There was no significant difference in the values of the haematological parameters from baseline values except neutrophil and lymphocyte values which had significant (p<0.05) decrease and increase respectively at 3 hours post anaesthesia compared with the values at 1 hour post drug administration. There was a transient non-significant (p˃ 0.05) decrease in AST and ALT values, and a marked non-significant (p˃ 0.05) decrease in ALP value at 1 hour post drug administration in comparison with base line values. Creatinine and BUN had fluctuating values with no significant change. It was concluded that epidural ropivacaine anaesthesia produced good epidural analgesia with no systemic toxicity and without adverse effects on the haematology, renal and hepatic biomarkers in West African Dwarf goats and may be recommended as an alternative to other local anaesthetic amides especially in West African Dwarf goats with debilitating diseases, prolonged dystocia and chronic ruminal tympany, where drug toxicity and safety are major concerns.
{"title":"Haematobiochemical Responses of West African Dwarf Goats to Epidural Ropivacaine Anaesthesia","authors":"C. Oguntoye, Abayomi Kayode Olaifa, Faith Ifeoluwa Adewale","doi":"10.31487/j.acr.2022.01.03","DOIUrl":"https://doi.org/10.31487/j.acr.2022.01.03","url":null,"abstract":"Haematobiochemical responses following epidural administration of ropivacaine to West African Dwarf (WAD) goats were studied. Complete analgesia of the flank, abdomen and hindlimbs was achieved in all the goats. Transient non- significant (p > 0.05) increase in haematocrit and neutrophil values and a transient lymphocytopaenia were observed at 1 hour post epidural drug administration. There was also a transient non- significant increase (p > 0.05) in RBC, haemoglobin, WBC but decrease platelets at 1 hour post epidural drug administration. There was no significant difference in the values of the haematological parameters from baseline values except neutrophil and lymphocyte values which had significant (p<0.05) decrease and increase respectively at 3 hours post anaesthesia compared with the values at 1 hour post drug administration. There was a transient non-significant (p˃ 0.05) decrease in AST and ALT values, and a marked non-significant (p˃ 0.05) decrease in ALP value at 1 hour post drug administration in comparison with base line values. Creatinine and BUN had fluctuating values with no significant change. It was concluded that epidural ropivacaine anaesthesia produced good epidural analgesia with no systemic toxicity and without adverse effects on the haematology, renal and hepatic biomarkers in West African Dwarf goats and may be recommended as an alternative to other local anaesthetic amides especially in West African Dwarf goats with debilitating diseases, prolonged dystocia and chronic ruminal tympany, where drug toxicity and safety are major concerns.","PeriodicalId":15000,"journal":{"name":"Journal of Anesthesia and Clinical Research","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86206973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-16DOI: 10.31487/j.acr.2022.01.01
Cornelius Husemann, H. Hautmann
Background: The increasing use of flexible bronchoscopy for diagnostic and interventional purposes requires further knowledge on feasible sedation regimens. We investigated the potential benefit of Target- Controlled Infusion (TCI) of propofol on sedation depth. Methods: Fifty-four patients scheduled for elective flexible bronchoscopy were allocated to receive propofol sedation using either intermittent boluses or Target Controlled Infusion (TCI). Endpoints included Entropy monitoring to evaluate sedation depth, sedation quality and the total amount of propofol. Results: There were no significant differences between both cohorts regarding the number of adverse sedation-related events. The mean applied dose of propofol was significantly higher in the Target-Controlled Infusion group (405±249 mg vs. 324±94 mg, p=0.015). Until patients reached loss of consciousness (LOC), State Entropy (SE) and Response Entropy (RE) levels were comparable among both sedation regimens. During the procedure, both parameters decreased to significantly lower levels in the TCI-cohort (SE: 77.7±13.2 vs. 88.8±8.6 (p=0.002) and RE: 69±12.6 vs. 79±8.7 (p=0.005)). Examination conditions, as rated by proceduralists and assisting nurses, were superior in the TCI-cohort. In addition, restraining measurements, due to uncontrolled movement during the examination needed to be applied more often to patients in the bolus cohort (body restraint: 26 (96%) vs. 18 (67%), p=0.005). Conclusion: Target-Controlled Infusion of propofol complies with the requirements of flexible bronchoscopy by providing a deep and steady level of sedation without impairing patient’s safety. In addition, there is evidence that overall sedation quality is superior, both for bronchoscopist and assisting staff.
{"title":"Impact of Target-Controlled Infusion (TCI) of Propofol on State- and Response-Entropy and Sedation Depth During Flexible Bronchoscopy","authors":"Cornelius Husemann, H. Hautmann","doi":"10.31487/j.acr.2022.01.01","DOIUrl":"https://doi.org/10.31487/j.acr.2022.01.01","url":null,"abstract":"Background: The increasing use of flexible bronchoscopy for diagnostic and interventional purposes requires further knowledge on feasible sedation regimens. We investigated the potential benefit of Target- Controlled Infusion (TCI) of propofol on sedation depth. \u0000Methods: Fifty-four patients scheduled for elective flexible bronchoscopy were allocated to receive propofol sedation using either intermittent boluses or Target Controlled Infusion (TCI). Endpoints included Entropy monitoring to evaluate sedation depth, sedation quality and the total amount of propofol. \u0000Results: There were no significant differences between both cohorts regarding the number of adverse sedation-related events. The mean applied dose of propofol was significantly higher in the Target-Controlled Infusion group (405±249 mg vs. 324±94 mg, p=0.015). Until patients reached loss of consciousness (LOC), State Entropy (SE) and Response Entropy (RE) levels were comparable among both sedation regimens. During the procedure, both parameters decreased to significantly lower levels in the TCI-cohort (SE: 77.7±13.2 vs. 88.8±8.6 (p=0.002) and RE: 69±12.6 vs. 79±8.7 (p=0.005)). Examination conditions, as rated by proceduralists and assisting nurses, were superior in the TCI-cohort. In addition, restraining measurements, due to uncontrolled movement during the examination needed to be applied more often to patients in the bolus cohort (body restraint: 26 (96%) vs. 18 (67%), p=0.005).\u0000Conclusion: Target-Controlled Infusion of propofol complies with the requirements of flexible bronchoscopy by providing a deep and steady level of sedation without impairing patient’s safety. In addition, there is evidence that overall sedation quality is superior, both for bronchoscopist and assisting staff.","PeriodicalId":15000,"journal":{"name":"Journal of Anesthesia and Clinical Research","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78799320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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