Pub Date : 2019-09-30DOI: 10.31216/bdl.2019.9.3.113
Jisub Moon, Heesun Gwak, Tae-Hee Lee, E. An, Yun-Bae Kim, Dongsun Park
Polyphenols can easily react with reactive oxygen species (ROS) resulting in powerful antioxidant activity. Pyrogallol is a polyphenol found in a variety of fruits and vegetables. Therefore, plants containing pyrogallol can be used for their antioxidant, anti-bacterial, anti-fungal, anti-allergic, and anti-inflammatory properties. However, its effectiveness as an antioxidant is still a matter of debate because pyrogallol is also a superoxide anion generator and induces superoxide anion-mediated death of several types of cells. In this study, we tried to confirm the antioxidant effects and mechanisms of pyrogallol in mouse neuroblastoma (N2A), human neural stem cells (F3), and mouse brain. Treatments with various concentrations of pyrogallol significantly increased the free radical scavenging ability and reduced lipid peroxidation in N2A and F3 cells in a concentration-dependent manner. In the cytotoxicity test, low concentrations of pyrogallol (0–10 µg/mL) did not significantly influence cell viability, while high concentrations (125-1000 µg/mL) induced death in N2a and F3 cells. Furthermore, treatment with pyrogallol(1.0, 3.2, and 10.0 µg/mL) up-regulated the mRNA expression of superoxide dismutases 1, 2, and 3, glutathione peroxidase (GPx)1, and phospholipid hydroperoxide GPx in N2A and F3 cells, in the brains of mice that were orally administered pyrogallol (1.0, 3.2, and 10.0 mg/kg/day) for 7 days. The mice did not exhibit any toxic effects due to this treatment. Taken together, although pyrogallol induced cell death at high concentrations, it might be a good candidate antioxidant for neurodegenerative disease at low concentrations.
{"title":"Antioxidant Effects of Pyrogallol in Neural Cells and Mice Brain","authors":"Jisub Moon, Heesun Gwak, Tae-Hee Lee, E. An, Yun-Bae Kim, Dongsun Park","doi":"10.31216/bdl.2019.9.3.113","DOIUrl":"https://doi.org/10.31216/bdl.2019.9.3.113","url":null,"abstract":"Polyphenols can easily react with reactive oxygen species (ROS) resulting in powerful antioxidant activity. Pyrogallol is a polyphenol found in a variety of fruits and vegetables. Therefore, plants containing pyrogallol can be used for their antioxidant, anti-bacterial, anti-fungal, anti-allergic, and anti-inflammatory properties. However, its effectiveness as an antioxidant is still a matter of debate because pyrogallol is also a superoxide anion generator and induces superoxide anion-mediated death of several types of cells. In this study, we tried to confirm the antioxidant effects and mechanisms of pyrogallol in mouse neuroblastoma (N2A), human neural stem cells (F3), and mouse brain. Treatments with various concentrations of pyrogallol significantly increased the free radical scavenging ability and reduced lipid peroxidation in N2A and F3 cells in a concentration-dependent manner. In the cytotoxicity test, low concentrations of pyrogallol (0–10 µg/mL) did not significantly influence cell viability, while high concentrations (125-1000 µg/mL) induced death in N2a and F3 cells. Furthermore, treatment with pyrogallol(1.0, 3.2, and 10.0 µg/mL) up-regulated the mRNA expression of superoxide dismutases 1, 2, and 3, glutathione peroxidase (GPx)1, and phospholipid hydroperoxide GPx in N2A and F3 cells, in the brains of mice that were orally administered pyrogallol (1.0, 3.2, and 10.0 mg/kg/day) for 7 days. The mice did not exhibit any toxic effects due to this treatment. Taken together, although pyrogallol induced cell death at high concentrations, it might be a good candidate antioxidant for neurodegenerative disease at low concentrations.","PeriodicalId":151346,"journal":{"name":"Institute of Brain-based Education, Korea National University of Education","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116796722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-30DOI: 10.31216/bdl.2019.9.3.241
Kimjongin, Ryu Kwang-Su
{"title":"Development of STEAM Integrated Teaching Materials using Solid Crystal Structure","authors":"Kimjongin, Ryu Kwang-Su","doi":"10.31216/bdl.2019.9.3.241","DOIUrl":"https://doi.org/10.31216/bdl.2019.9.3.241","url":null,"abstract":"","PeriodicalId":151346,"journal":{"name":"Institute of Brain-based Education, Korea National University of Education","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128373407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-30DOI: 10.31216/bdl.2019.9.3.189
Seong-yeob Jeong, Lim， Soo-min, Youngshin Kim
{"title":"Coherence on Concepts Used in Science Inquiry Activities","authors":"Seong-yeob Jeong, Lim， Soo-min, Youngshin Kim","doi":"10.31216/bdl.2019.9.3.189","DOIUrl":"https://doi.org/10.31216/bdl.2019.9.3.189","url":null,"abstract":"","PeriodicalId":151346,"journal":{"name":"Institute of Brain-based Education, Korea National University of Education","volume":"13 6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130157397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-30DOI: 10.31216/bdl.2019.9.3.271
Yunhee Seung
{"title":"A Comparative Study on Brain Preference and Music Teaching Style of Elementary and Middle School Teachers According to Alert Scale of Cognitive Style","authors":"Yunhee Seung","doi":"10.31216/bdl.2019.9.3.271","DOIUrl":"https://doi.org/10.31216/bdl.2019.9.3.271","url":null,"abstract":"","PeriodicalId":151346,"journal":{"name":"Institute of Brain-based Education, Korea National University of Education","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132620847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-30DOI: 10.31216/bdl.2019.9.3.105
Hyeongseok Jeon, Junhee Lee, June Lee, Youjin Hwang, Siyoung Lee, Hee Yang, J. Yoon, J. Kwon, J. Won, J. Cho, K. Lee
{"title":"Predicting Attention and Memory Ability based on the Combination of EEG and HRV data in Children","authors":"Hyeongseok Jeon, Junhee Lee, June Lee, Youjin Hwang, Siyoung Lee, Hee Yang, J. Yoon, J. Kwon, J. Won, J. Cho, K. Lee","doi":"10.31216/bdl.2019.9.3.105","DOIUrl":"https://doi.org/10.31216/bdl.2019.9.3.105","url":null,"abstract":"","PeriodicalId":151346,"journal":{"name":"Institute of Brain-based Education, Korea National University of Education","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129884583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-06-30DOI: 10.31216/BDL.2019.9.2.029
Dongkwang Shin
{"title":"Feasibility and Constraints in Applying an AI Chatbot to English Education","authors":"Dongkwang Shin","doi":"10.31216/BDL.2019.9.2.029","DOIUrl":"https://doi.org/10.31216/BDL.2019.9.2.029","url":null,"abstract":"","PeriodicalId":151346,"journal":{"name":"Institute of Brain-based Education, Korea National University of Education","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129932827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-06-30DOI: 10.31216/BDL.2019.9.2.041
Byeoung-Uk Kim, Hyunil Jung
{"title":"A Study on the Possibility of Practice of Art Education in Schools and Village Education Community","authors":"Byeoung-Uk Kim, Hyunil Jung","doi":"10.31216/BDL.2019.9.2.041","DOIUrl":"https://doi.org/10.31216/BDL.2019.9.2.041","url":null,"abstract":"","PeriodicalId":151346,"journal":{"name":"Institute of Brain-based Education, Korea National University of Education","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121412833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-06-30DOI: 10.31216/BDL.2019.9.2.059
Kim Kukhyeon
{"title":"Reflective narrative approach to changes of Korean textbook system","authors":"Kim Kukhyeon","doi":"10.31216/BDL.2019.9.2.059","DOIUrl":"https://doi.org/10.31216/BDL.2019.9.2.059","url":null,"abstract":"","PeriodicalId":151346,"journal":{"name":"Institute of Brain-based Education, Korea National University of Education","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133553105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-06-30DOI: 10.31216/BDL.2019.9.2.019
Lee Kyunghwa, Choi Sookki, Lee Gyeong-Nam, Kang Seo-Hee, Kim Tae-Ho
{"title":"Development of Reading Ability Diagnosis Indicators using Eye tracker","authors":"Lee Kyunghwa, Choi Sookki, Lee Gyeong-Nam, Kang Seo-Hee, Kim Tae-Ho","doi":"10.31216/BDL.2019.9.2.019","DOIUrl":"https://doi.org/10.31216/BDL.2019.9.2.019","url":null,"abstract":"","PeriodicalId":151346,"journal":{"name":"Institute of Brain-based Education, Korea National University of Education","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129709976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-06-30DOI: 10.31216/BDL.2019.9.2.009
Tae-hoon Kim, Yong-Ju Kwon
{"title":"Development of A Digital Textbook on Metabolism and Digestion System Applying the 5E Learning Cycle Model in High School Life Science","authors":"Tae-hoon Kim, Yong-Ju Kwon","doi":"10.31216/BDL.2019.9.2.009","DOIUrl":"https://doi.org/10.31216/BDL.2019.9.2.009","url":null,"abstract":"","PeriodicalId":151346,"journal":{"name":"Institute of Brain-based Education, Korea National University of Education","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121164292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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