Rhythm control therapy improves the quality of life and prognosis of patients with atrial fibrillation (AF). We assessed the characteristics and clinical outcomes of AF patients with stable coronary artery disease (CAD) undergoing rhythm control therapy.
Methods
We analyzed 2215 participants from the Atrial Fibrillation and Ischemic Events with Rivaroxaban in Patients with Stable Coronary Artery Disease (AFIRE) trial, including 588 patients who received rhythm control therapy and 1627 who did not.
Results
At baseline, patients who received rhythm control therapy were generally younger, exhibited a higher prevalence of paroxysmal AF, experienced less heart failure, and had lower CHADS2 scores (CHF, hypertension, age ≥ 75 years, type 2 diabetes, and previous stroke or transient ischemic attack [doubled]) than those who did not. Among the rivaroxaban monotherapy and combination therapy groups, patients with a history of rhythm control therapy showed a lower incidence of the primary efficacy endpoint (a composite of stroke, systemic embolism, myocardial infarction, unstable angina requiring revascularization, or death). However, following multivariate analysis and propensity score matching, no statistically significant difference in the primary efficacy endpoint was observed between patients with and without prior rhythm control therapy (adjusted HR 0.75, 95% CI 0.37–1.51, p = 0.43 in the rivaroxaban group; adjusted HR 0.75, 95% CI 0.43–1.30, p = 0.30 in the combination therapy group).
Conclusions
The initially observed benefit of rhythm control therapy was not significant after adjusting for baseline characteristics in patients with AF and stable CAD treated with rivaroxaban with or without additional antiplatelet therapy.
背景：心律控制治疗可改善心房颤动（AF）患者的生活质量和预后。我们评估了房颤合并稳定冠状动脉疾病（CAD）患者接受心律控制治疗的特点和临床结果。方法：我们分析了2215名来自利伐沙班治疗稳定型冠状动脉疾病（AFIRE）患者心房颤动和缺血性事件试验的参与者，其中588名患者接受了心律控制治疗，1627名患者未接受心律控制治疗。结果：在基线时，接受心律控制治疗的患者通常更年轻，阵发性房颤患病率更高，心力衰竭发生率更低，CHADS2评分（CHF、高血压、年龄≥75岁、2型糖尿病、既往卒中或短暂性脑缺血发作[翻倍]）低于未接受治疗的患者。在利伐沙班单药和联合治疗组中，有节律控制治疗史的患者的主要疗效终点（卒中、全身栓塞、心肌梗死、需要血运重建的不稳定型心绞痛或死亡）的发生率较低。然而，通过多因素分析和倾向评分匹配，未观察到接受和未接受过心律控制治疗的患者在主要疗效终点上的差异（利伐沙班组调整HR 0.75, 95% CI 0.37-1.51, p = 0.43；联合治疗组调整HR 0.75, 95% CI 0.43-1.30, p = 0.30）。结论：在利伐沙班联合或不联合抗血小板治疗的房颤和稳定型CAD患者的基线特征调整后，最初观察到的心律控制治疗的益处并不显著。
{"title":"Association Between History of Rhythm Control Therapy and Clinical Outcomes in Atrial Fibrillation Patients With Stable Coronary Artery Disease: A Sub-Analysis of the AFIRE Trial","authors":"Daisuke Wakatsuki, Hiroshi Suzuki, Koichi Kaikita, Masaharu Akao, Junya Ako, Tetsuya Matoba, Masato Nakamura, Katsumi Miyauchi, Nobuhisa Hagiwara, Kazuo Kimura, Atsushi Hirayama, Kunihiko Matsui, Hisao Ogawa, Satoshi Yasuda","doi":"10.1002/joa3.70210","DOIUrl":"10.1002/joa3.70210","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Rhythm control therapy improves the quality of life and prognosis of patients with atrial fibrillation (AF). We assessed the characteristics and clinical outcomes of AF patients with stable coronary artery disease (CAD) undergoing rhythm control therapy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We analyzed 2215 participants from the Atrial Fibrillation and Ischemic Events with Rivaroxaban in Patients with Stable Coronary Artery Disease (AFIRE) trial, including 588 patients who received rhythm control therapy and 1627 who did not.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>At baseline, patients who received rhythm control therapy were generally younger, exhibited a higher prevalence of paroxysmal AF, experienced less heart failure, and had lower CHADS2 scores (CHF, hypertension, age ≥ 75 years, type 2 diabetes, and previous stroke or transient ischemic attack [doubled]) than those who did not. Among the rivaroxaban monotherapy and combination therapy groups, patients with a history of rhythm control therapy showed a lower incidence of the primary efficacy endpoint (a composite of stroke, systemic embolism, myocardial infarction, unstable angina requiring revascularization, or death). However, following multivariate analysis and propensity score matching, no statistically significant difference in the primary efficacy endpoint was observed between patients with and without prior rhythm control therapy (adjusted HR 0.75, 95% CI 0.37–1.51, <i>p</i> = 0.43 in the rivaroxaban group; adjusted HR 0.75, 95% CI 0.43–1.30, <i>p</i> = 0.30 in the combination therapy group).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The initially observed benefit of rhythm control therapy was not significant after adjusting for baseline characteristics in patients with AF and stable CAD treated with rivaroxaban with or without additional antiplatelet therapy.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15174,"journal":{"name":"Journal of Arrhythmia","volume":"41 6","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12628280/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145564047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jason Hui, Samual Turnbull, Ashwin Bhaskaran, Saurabh Kumar, Stefan Dieleman
Introduction
Catheter ablation is highly efficacious for the treatment of ventricular tachycardia (VT). In patients with structural heart disease, catheter ablation may be performed under general anesthesia (GA). There are limited data on the effect of anesthetic agents on VT inducibility. We compared VT inducibility using total intravenous anesthesia (TIVA) versus volatile anesthesia.
Methods
In this retrospective observational study, patients who underwent catheter ablation for VT between January 2019 and May 2023 were included. Clinical data, procedural reports, and long-term outcomes were collected from the electronic medical records. Patients were grouped based on the type of anesthetic agent used to maintain GA during the procedure.
Results
There were 207 patients maintained under GA using TIVA and 56 patients using volatile anesthesia. One hundred and seventy-five of the 207 (84.5%) patients in the TIVA group were inducible for VT compared to 38 of 56 (67.9%) in the volatile group (OR [95% CI]: 3.8 [1.4–10.4], p = 0.01). Male sex was identified as a potential factor associated with increased VT inducibility (OR [95% CI]: 4.7 [1.4–16.0], p = 0.01). TIVA patients had a shorter ventricular effective refractory period. However, there was no difference between either the number of extra stimuli needed to induce the VT, the proportion of VTs induced spontaneously, acute ablation success rate, or the incidence of VA recurrence.
Conclusion
Use of volatile GA agents was associated with a higher incidence of VT non-inducibility compared to TIVA. TIVA was associated with a lower risk of VA recurrence in follow-up. The observed effect on VT inducibility could be explained by effects on ventricular effective refractory period.
导读：导管消融治疗室性心动过速疗效显著。对于结构性心脏病患者，导管消融可在全身麻醉（GA）下进行。关于麻醉药对室速诱导性影响的数据有限。我们比较了全静脉麻醉（TIVA）和挥发性麻醉的VT诱导性。方法：在这项回顾性观察研究中，纳入了2019年1月至2023年5月期间因室性心动过速接受导管消融的患者。从电子病历中收集临床数据、程序报告和长期结果。根据手术过程中用于维持GA的麻醉剂类型对患者进行分组。结果：有207例患者采用TIVA维持GA， 56例采用挥发性麻醉维持GA。TIVA组207例患者中有175例（84.5%）可诱发VT，而挥发性肺栓塞组56例患者中有38例（67.9%）可诱发VT （OR [95% CI]: 3.8 [1.4-10.4], p = 0.01）。男性被认为是与VT诱发性增加相关的潜在因素（OR [95% CI]: 4.7 [1.4-16.0], p = 0.01）。TIVA患者心室有效不应期较短。然而，诱发室性心动过速所需的额外刺激次数、自发诱发室性心动过速的比例、急性消融成功率或室性心动过速复发率之间均无差异。结论：与TIVA相比，使用挥发性GA药物与更高的VT不可诱导性发生率相关。在随访中，TIVA与较低的VA复发风险相关。观察到的对室速诱导的影响可以通过对心室有效不应期的影响来解释。
{"title":"Comparison of Total Intravenous Anesthesia Versus Volatile Anesthesia on Arrhythmia Inducibility and Clinical Outcomes During Catheter Ablation for Ventricular Tachycardia","authors":"Jason Hui, Samual Turnbull, Ashwin Bhaskaran, Saurabh Kumar, Stefan Dieleman","doi":"10.1002/joa3.70218","DOIUrl":"10.1002/joa3.70218","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Catheter ablation is highly efficacious for the treatment of ventricular tachycardia (VT). In patients with structural heart disease, catheter ablation may be performed under general anesthesia (GA). There are limited data on the effect of anesthetic agents on VT inducibility. We compared VT inducibility using total intravenous anesthesia (TIVA) versus volatile anesthesia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this retrospective observational study, patients who underwent catheter ablation for VT between January 2019 and May 2023 were included. Clinical data, procedural reports, and long-term outcomes were collected from the electronic medical records. Patients were grouped based on the type of anesthetic agent used to maintain GA during the procedure.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>There were 207 patients maintained under GA using TIVA and 56 patients using volatile anesthesia. One hundred and seventy-five of the 207 (84.5%) patients in the TIVA group were inducible for VT compared to 38 of 56 (67.9%) in the volatile group (OR [95% CI]: 3.8 [1.4–10.4], <i>p</i> = 0.01). Male sex was identified as a potential factor associated with increased VT inducibility (OR [95% CI]: 4.7 [1.4–16.0], <i>p</i> = 0.01). TIVA patients had a shorter ventricular effective refractory period. However, there was no difference between either the number of extra stimuli needed to induce the VT, the proportion of VTs induced spontaneously, acute ablation success rate, or the incidence of VA recurrence.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Use of volatile GA agents was associated with a higher incidence of VT non-inducibility compared to TIVA. TIVA was associated with a lower risk of VA recurrence in follow-up. The observed effect on VT inducibility could be explained by effects on ventricular effective refractory period.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15174,"journal":{"name":"Journal of Arrhythmia","volume":"41 6","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12624363/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145556922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Radiation-free catheter ablation is feasible with modern electroanatomic mapping systems. We aimed to evaluate the feasibility, safety, and outcomes of non-fluoroscopic ablation (NFA) in patients with congenital heart disease (CHD).
Methods
We retrospectively reviewed CHD patients who underwent NFA between November 2016 and January 2025. All procedures were performed using the CARTO 3D electroanatomic mapping system. Atrial, ventricular, and aortic geometries were reconstructed as needed. Catheter navigation and sheath placement were guided without fluoroscopy; intracardiac echocardiography was used selectively.
Results
Forty-two patients (23 females) with CHD underwent NFA. The median age was 14 years (range 4–56), and median weight was 55 kg (range 19–145). Twenty-one patients had mild, 16 moderate complexity and 5 great complexity CHD. Arrhythmia mechanisms included AVNRT (14%), manifest WPW (21%), high-risk WPW without SVT (5%), concealed pathway AVRT (26%), AFL (12%), AT (14%), and VT (7%). Two patients had both AVNRT and AVRT. Acute success was achieved in all cases without fluoroscopy or acute complications. Over a median 48-month follow-up, three patients had recurrences: one with WPW and Ebstein anomaly, one with ASD/PLSVC and concealed pathway, and one with dual arrhythmia substrates.
Conclusion
Zero-fluoroscopy ablation of arrhythmias in select patients with mild moderate or great complexity CHD is feasible, safe, and effective, offering high acute success and low recurrence while eliminating radiation exposure.
{"title":"Zero Fluoroscopy Ablation of Arrhythmias in Patients With Congenital Heart Disease","authors":"Shailendra Upadhyay, Jenna Schermerhorn, Whitney Fairchild, Jamie Bopp, Irfan Warsy","doi":"10.1002/joa3.70225","DOIUrl":"https://doi.org/10.1002/joa3.70225","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>Radiation-free catheter ablation is feasible with modern electroanatomic mapping systems. We aimed to evaluate the feasibility, safety, and outcomes of non-fluoroscopic ablation (NFA) in patients with congenital heart disease (CHD).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We retrospectively reviewed CHD patients who underwent NFA between November 2016 and January 2025. All procedures were performed using the CARTO 3D electroanatomic mapping system. Atrial, ventricular, and aortic geometries were reconstructed as needed. Catheter navigation and sheath placement were guided without fluoroscopy; intracardiac echocardiography was used selectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Forty-two patients (23 females) with CHD underwent NFA. The median age was 14 years (range 4–56), and median weight was 55 kg (range 19–145). Twenty-one patients had mild, 16 moderate complexity and 5 great complexity CHD. Arrhythmia mechanisms included AVNRT (14%), manifest WPW (21%), high-risk WPW without SVT (5%), concealed pathway AVRT (26%), AFL (12%), AT (14%), and VT (7%). Two patients had both AVNRT and AVRT. Acute success was achieved in all cases without fluoroscopy or acute complications. Over a median 48-month follow-up, three patients had recurrences: one with WPW and Ebstein anomaly, one with ASD/PLSVC and concealed pathway, and one with dual arrhythmia substrates.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Zero-fluoroscopy ablation of arrhythmias in select patients with mild moderate or great complexity CHD is feasible, safe, and effective, offering high acute success and low recurrence while eliminating radiation exposure.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15174,"journal":{"name":"Journal of Arrhythmia","volume":"41 6","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/joa3.70225","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145572375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ibrahim Antoun, Ahmed Abdelrazik, Xin Li, Mahmoud Eldesouky, Kaung Myat Thu, Riyaz Somani, G. André Ng
Background
Pulmonary vein isolation (PVI) is central to controlling paroxysmal atrial fibrillation (AF). Pulsed-field ablation (PFA) offers a non-thermal alternative to conventional thermal techniques. The study compares changes in P-wave parameters following PFA, radiofrequency ablation (RF), and cryoballoon ablation (Cryo).
Methods
We retrospectively analysed 283 patients undergoing first-time PVI (RF 101, Cryo 125, PFA 57). Digital electrocardiograms (ECGs) were evaluated for P-wave duration (PWD), voltage (PWV), dispersion (PWDisp), and terminal force in lead V1 (PTFV1) before and immediately after ablation. AF recurrence was assessed at 12 months. Analyses were adjusted for left atrial volume index (LAVI) and post-procedural anti-arrhythmic drug (AAD) use.
Results
At 12 months, 215 patients (76%) remained free of AF (RF 76%, Cryo 74%, PFA 79%; p = 0.78). Baseline PWD was 128.5 ± 14 ms (RF), 123.7 ± 15 ms (Cryo), and 124.2 ± 16 ms (PFA). Post-ablation, mean ΔPWD was +12.2 ms (RF), +8.5 ms (Cryo), and + 4.7 ms (PFA). PTFV1 decreased after all modalities: RF −3.3 to −4.6 mm·ms (p < 0.001), Cryo −3.4 to −5.3 mm·ms (p = 0.002), PFA −3.6 to −5.2 mm·ms (p = 0.005). No significant intergroup differences were observed (p = 0.39). Patients with AF recurrence (n = 68) had longer baseline PWD (128 ± 16 vs. 125 ± 14 ms, p = 0.12), longer post-procedural PWD (138 ± 17 vs. 129 ± 15 ms, p = 0.004), and larger LAVI (29.1 ± 7.9 vs. 25.3 ± 8.5 mL/m2,p = 0.03). In multivariable Cox models, increased post-procedural PWD independently predicted recurrence (HR: RF 1.17, Cryo 1.14, PFA 1.13; all p < 0.05).
Conclusions
PFA, RF, and Cryo produce similar acute ECG changes. Post-procedural PWD was the strongest predictor of AF recurrence, independent of atrial size and AAD use.
背景：肺静脉隔离（PVI）是控制阵发性心房颤动（AF）的核心。脉冲场烧蚀（PFA）是传统热技术的一种非热替代技术。该研究比较了PFA、射频消融（RF）和低温球囊消融（Cryo）后p波参数的变化。方法：回顾性分析283例首次行PVI的患者（RF 101, Cryo 125, PFA 57）。在消融前和消融后立即评估数字心电图（ecg）的p波持续时间（PWD）、电压（PWV）、弥散（PWDisp）和导联V1末端力（PTFV1）。12个月时评估房颤复发。分析调整左心房容积指数（LAVI）和术后抗心律失常药物（AAD）的使用。结果：12个月时，215例（76%）患者仍无房颤（RF 76%, Cryo 74%, PFA 79%; p = 0.78）。基线PWD为128.5±14 ms (RF), 123.7±15 ms （Cryo）和124.2±16 ms （PFA）。消融后，平均ΔPWD为+12.2 ms (RF), +8.5 ms （Cryo）和+ 4.7 ms （PFA）。所有模式后PTFV1均下降：RF -3.3至-4.6 mm·ms (p = 0.002), PFA -3.6至-5.2 mm·ms （p = 0.005）。组间差异无统计学意义（p = 0.39）。AF复发患者（n = 68）基线PWD较长（128±16 vs 125±14 ms, p = 0.12），术后PWD较长（138±17 vs 129±15 ms, p = 0.004）， LAVI较大（29.1±7.9 vs 25.3±8.5 mL/m2,p = 0.03）。在多变量Cox模型中，术后PWD升高独立预测复发(HR: RF 1.17, Cryo 1.14, PFA 1.13；所有p结论：PFA、RF和Cryo产生相似的急性心电图变化。术后PWD是房颤复发的最强预测因子，与心房大小和AAD使用无关。
{"title":"P-Wave Parameter Changes After Pulsed-Field Ablation, Cryoballoon Ablation and Radiofrequency Ablation for Paroxysmal Atrial Fibrillation: An Observational Cohort Study","authors":"Ibrahim Antoun, Ahmed Abdelrazik, Xin Li, Mahmoud Eldesouky, Kaung Myat Thu, Riyaz Somani, G. André Ng","doi":"10.1002/joa3.70224","DOIUrl":"10.1002/joa3.70224","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Pulmonary vein isolation (PVI) is central to controlling paroxysmal atrial fibrillation (AF). Pulsed-field ablation (PFA) offers a non-thermal alternative to conventional thermal techniques. The study compares changes in P-wave parameters following PFA, radiofrequency ablation (RF), and cryoballoon ablation (Cryo).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We retrospectively analysed 283 patients undergoing first-time PVI (RF 101, Cryo 125, PFA 57). Digital electrocardiograms (ECGs) were evaluated for P-wave duration (PWD), voltage (PWV), dispersion (PWDisp), and terminal force in lead V1 (PTFV1) before and immediately after ablation. AF recurrence was assessed at 12 months. Analyses were adjusted for left atrial volume index (LAVI) and post-procedural anti-arrhythmic drug (AAD) use.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>At 12 months, 215 patients (76%) remained free of AF (RF 76%, Cryo 74%, PFA 79%; <i>p</i> = 0.78). Baseline PWD was 128.5 ± 14 ms (RF), 123.7 ± 15 ms (Cryo), and 124.2 ± 16 ms (PFA). Post-ablation, mean ΔPWD was +12.2 ms (RF), +8.5 ms (Cryo), and + 4.7 ms (PFA). PTFV1 decreased after all modalities: RF −3.3 to −4.6 mm·ms (<i>p</i> < 0.001), Cryo −3.4 to −5.3 mm·ms (<i>p</i> = 0.002), PFA −3.6 to −5.2 mm·ms (<i>p</i> = 0.005). No significant intergroup differences were observed (<i>p</i> = 0.39). Patients with AF recurrence (<i>n</i> = 68) had longer baseline PWD (128 ± 16 vs. 125 ± 14 ms, <i>p</i> = 0.12), longer post-procedural PWD (138 ± 17 vs. 129 ± 15 ms, <i>p</i> = 0.004), and larger LAVI (29.1 ± 7.9 vs. 25.3 ± 8.5 mL/m<sup>2</sup>,<i>p</i> = 0.03). In multivariable Cox models, increased post-procedural PWD independently predicted recurrence (HR: RF 1.17, Cryo 1.14, PFA 1.13; all <i>p</i> < 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>PFA, RF, and Cryo produce similar acute ECG changes. Post-procedural PWD was the strongest predictor of AF recurrence, independent of atrial size and AAD use.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15174,"journal":{"name":"Journal of Arrhythmia","volume":"41 6","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12620618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145549455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This case demonstrates an unintentional bidirectional mitral isthmus block created during pulmonary vein isolation using a pentaspline pulsed-field ablation catheter. The finding underscores the importance of careful sheath–catheter alignment at the left inferior pulmonary vein to prevent unintended lesion extension toward the mitral annulus.
{"title":"Unintentional Mitral Lateral Isthmus Block During Pulmonary Vein Isolation With a Pentaspline Pulsed-Field Ablation Catheter","authors":"Yuhei Kasai, Takayuki Kitai, Junji Morita, Kei Murakami, Kazuhiro Satomi","doi":"10.1002/joa3.70226","DOIUrl":"10.1002/joa3.70226","url":null,"abstract":"<p>This case demonstrates an unintentional bidirectional mitral isthmus block created during pulmonary vein isolation using a pentaspline pulsed-field ablation catheter. The finding underscores the importance of careful sheath–catheter alignment at the left inferior pulmonary vein to prevent unintended lesion extension toward the mitral annulus.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":15174,"journal":{"name":"Journal of Arrhythmia","volume":"41 6","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12620617/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145549436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A case of torsades de pointes triggered by transient bradycardia during Micra AV2 setup highlights a proarrhythmic risk of automated initialization. Individualized programming may be necessary in high-risk patients with QT prolongation.
{"title":"Torsades de Pointes Triggered by Transient Low-Rate Pacing Following Leadless Pacemaker Implantation","authors":"Yumetsugu Munakata, Junji Morita, Yuhei Kasai, Takayuki Kitai, Yusuke Kondo","doi":"10.1002/joa3.70220","DOIUrl":"https://doi.org/10.1002/joa3.70220","url":null,"abstract":"<p>A case of torsades de pointes triggered by transient bradycardia during Micra AV2 setup highlights a proarrhythmic risk of automated initialization. Individualized programming may be necessary in high-risk patients with QT prolongation.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":15174,"journal":{"name":"Journal of Arrhythmia","volume":"41 6","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/joa3.70220","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145521821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Arrhythmias are diagnosed using electrocardiograms (ECGs). Particularly for paroxysmal arrhythmias, an ECG recorded during an episode is essential for definitive diagnosis. Meanwhile, biomarkers assessable through blood tests do not directly diagnose arrhythmias, but are considered useful for evaluating the prevalence of paroxysmal arrhythmias, predicting their onset, assessing severity, and evaluating the risk of complications. While most biomarker research in the arrhythmia field focuses on atrial fibrillation, several studies have also reported on the prediction of ventricular arrhythmias and sudden death. This paper defines biomarkers as substances measurable and evaluable through blood tests and primarily discusses their relationship with atrial fibrillation and its complications.
{"title":"Perspectives on Clinical Biomarkers Based on the Pathophysiology of Arrhythmias","authors":"Tomoya Hara, Masataka Sata","doi":"10.1002/joa3.70221","DOIUrl":"10.1002/joa3.70221","url":null,"abstract":"<p>Arrhythmias are diagnosed using electrocardiograms (ECGs). Particularly for paroxysmal arrhythmias, an ECG recorded during an episode is essential for definitive diagnosis. Meanwhile, biomarkers assessable through blood tests do not directly diagnose arrhythmias, but are considered useful for evaluating the prevalence of paroxysmal arrhythmias, predicting their onset, assessing severity, and evaluating the risk of complications. While most biomarker research in the arrhythmia field focuses on atrial fibrillation, several studies have also reported on the prediction of ventricular arrhythmias and sudden death. This paper defines biomarkers as substances measurable and evaluable through blood tests and primarily discusses their relationship with atrial fibrillation and its complications.</p>","PeriodicalId":15174,"journal":{"name":"Journal of Arrhythmia","volume":"41 6","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12606446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145512944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yasuharu Matsunaga-Lee, Yasuyuki Egami, Koji Yasumoto, Masamichi Yano, Masami Nishino
Both AVNRT and NF-ORT can be sustained with HV block. His–tachycardia dissociation during ventricular overdrive pacing is a key finding for differentiating AVNRT from NF-ORT.
{"title":"Highlighting the Importance of His Bundle Potential During Tachycardia and Ventricular Overdrive Pacing","authors":"Yasuharu Matsunaga-Lee, Yasuyuki Egami, Koji Yasumoto, Masamichi Yano, Masami Nishino","doi":"10.1002/joa3.70217","DOIUrl":"10.1002/joa3.70217","url":null,"abstract":"<p>Both AVNRT and NF-ORT can be sustained with HV block. His–tachycardia dissociation during ventricular overdrive pacing is a key finding for differentiating AVNRT from NF-ORT.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":15174,"journal":{"name":"Journal of Arrhythmia","volume":"41 6","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12598571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145495479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Preprocedural 3D-CT identified a suitable posterolateral coronary vein in a patient with dextrocardia and situs inversus. Right-sided CRT-D implantation guided by 3D imaging achieved optimal lead positioning and biventricular pacing, underscoring the importance of preprocedural anatomical planning in complex congenital settings.
{"title":"Successful Cardiac Resynchronization Therapy With Defibrillator Implantation in a Patient With Isolated Dextrocardia and Situs Inversus Totalis: Role of High-Resolution Three-Dimensional Computed Tomography in Procedural Planning","authors":"Masako Asami, Yoshinari Enomoto, Naohiko Sahara, Keijiro Nakamura, Hidehiko Hara","doi":"10.1002/joa3.70219","DOIUrl":"10.1002/joa3.70219","url":null,"abstract":"<p>Preprocedural 3D-CT identified a suitable posterolateral coronary vein in a patient with dextrocardia and situs inversus. Right-sided CRT-D implantation guided by 3D imaging achieved optimal lead positioning and biventricular pacing, underscoring the importance of preprocedural anatomical planning in complex congenital settings.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":15174,"journal":{"name":"Journal of Arrhythmia","volume":"41 6","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12602261/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145504497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
George Bazoukis, Athanasios Saplaouras, Nikhil Pillai, Polyxeni Efthymiou, Sharen Lee, Dimitrios Sfairopoulos, Panagiotis Korantzopoulos, Gary Tse, Tong Liu, Konstantinos P. Letsas
Background
The identification of arrhythmogenic right ventricular cardiomyopathy (ARVC) patients at risk for fatal arrhythmic events is of great importance in clinical practice. Conflicting data exist regarding the role of electrophysiological study (EPS) in this setting. We aimed to examine the association of EPS inducibility with future fatal arrhythmic events in ARVC patients and its role as a risk stratification tool in the setting of primary prevention of sudden cardiac death (SCD).
Methods
This meta-analysis was prepared in adherence to the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines.
Results
Eleven studies provided data on the association between EPS inducibility and fatal arrhythmic events and were therefore included in the quantitative analysis. EPS inducibility was significantly associated with arrhythmic events (RR: 2.15, 95% CI [1.63–2.85], p < 0.001) in the analysis that included patients with or without prior arrhythmic events. By including only patients without prior arrhythmic events, EPS inducibility was also significantly associated with arrhythmic events (RR: 1.93, 95% CI [1.20–3.10], p = 0.007).
Conclusions
EPS inducibility can be a valuable tool for arrhythmic risk stratification purposes in ARVC patients, especially as a component of multiparametric risk scores. More studies are needed to examine the role of multiparametric risk scores, including EPS inducibility, in identifying ARVC patients at risk for fatal arrhythmic events.
背景：识别有致死性心律失常危险的心律失常性右室心肌病（ARVC）患者在临床实践中具有重要意义。关于电生理研究（EPS）在这种情况下的作用存在矛盾的数据。我们的目的是研究EPS诱导与ARVC患者未来致命性心律失常事件的关系，以及它在心脏性猝死（SCD）一级预防中作为风险分层工具的作用。方法：本荟萃分析是按照系统评价和荟萃分析的首选报告项目（PRISMA）指南准备的。结果：11项研究提供了EPS诱导与致死性心律失常事件之间关系的数据，因此被纳入定量分析。EPS诱导性与心律失常事件显著相关（RR: 2.15, 95% CI [1.63-2.85], p = 0.007）。结论：EPS诱导可作为ARVC患者心律失常风险分层的重要工具，尤其是作为多参数风险评分的一个组成部分。需要更多的研究来检验多参数风险评分，包括EPS诱导性，在识别ARVC患者有致命性心律失常事件风险方面的作用。
{"title":"The Role of Ventricular Arrhythmias Inducibility in Arrhythmic Risk Stratification in Arrhythmogenic Right Ventricular Cardiomyopathy: A Meta-Analysis of Observational Studies","authors":"George Bazoukis, Athanasios Saplaouras, Nikhil Pillai, Polyxeni Efthymiou, Sharen Lee, Dimitrios Sfairopoulos, Panagiotis Korantzopoulos, Gary Tse, Tong Liu, Konstantinos P. Letsas","doi":"10.1002/joa3.70204","DOIUrl":"10.1002/joa3.70204","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The identification of arrhythmogenic right ventricular cardiomyopathy (ARVC) patients at risk for fatal arrhythmic events is of great importance in clinical practice. Conflicting data exist regarding the role of electrophysiological study (EPS) in this setting. We aimed to examine the association of EPS inducibility with future fatal arrhythmic events in ARVC patients and its role as a risk stratification tool in the setting of primary prevention of sudden cardiac death (SCD).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This meta-analysis was prepared in adherence to the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Eleven studies provided data on the association between EPS inducibility and fatal arrhythmic events and were therefore included in the quantitative analysis. EPS inducibility was significantly associated with arrhythmic events (RR: 2.15, 95% CI [1.63–2.85], <i>p</i> < 0.001) in the analysis that included patients with or without prior arrhythmic events. By including only patients without prior arrhythmic events, EPS inducibility was also significantly associated with arrhythmic events (RR: 1.93, 95% CI [1.20–3.10], <i>p</i> = 0.007).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>EPS inducibility can be a valuable tool for arrhythmic risk stratification purposes in ARVC patients, especially as a component of multiparametric risk scores. More studies are needed to examine the role of multiparametric risk scores, including EPS inducibility, in identifying ARVC patients at risk for fatal arrhythmic events.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15174,"journal":{"name":"Journal of Arrhythmia","volume":"41 6","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12579493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145431414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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