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True- and pseudo-mitral annular disjunction in patients undergoing cardiovascular magnetic resonance. 接受心血管磁共振的患者的真、假二尖瓣环分离。
IF 4.2 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-12-30 DOI: 10.1016/j.jocmr.2024.101413
Kamil Stankowski, Federica Catapano, Dario Donia, Renato Maria Bragato, Pedro Lopes, João Abecasis, António Ferreira, Leandro Slipczuk, Pier-Giorgio Masci, Gianluigi Condorelli, Marco Francone, Stefano Figliozzi

Background: Mitral annular disjunction (MAD) is a controversial entity. Recently, a distinction between pseudo-MAD, present in systole and secondary to juxtaposition of the billowing posterior leaflet on the left atrial wall, and true-MAD, where the insertion of the posterior leaflet is displaced on the atrial wall both in diastole or in systole, has been proposed. We investigated the prevalence of pseudo-MAD and true-MAD.

Methods: This was a retrospective study, including consecutive patients referred to cardiovascular magnetic resonance (CMR). MAD was defined as a ≥1 mm displacement between the left atrial wall-mitral valve leaflet junction hinge and the top of the left ventricular wall, measured from cine-CMR images in the three long-axis views. Pseudo-MAD and true-MAD were defined as the presence of MAD only in systole or both in systole and diastole, respectively.

Results: Two hundred and ninety patients (59 [47-71] years; 181/290 men, 62%) were included. Mitral valve prolapse (MVP) and MAD were found in 24/290 (8%) and 145/290 (50%) patients, of which 100/290 (35%) with true-MAD and 45/290 (16%) with pseudo-MAD. In all measurements, systolic MAD extent (2.3 [1.7-3.0] mm) resulted equal to or greater than diastolic MAD extent (2.0 [1.5-2.9] mm). The most frequent MAD location was the inferior wall (117/290, 40%) and the inferolateral wall was the rarest (50/290, 17%). In patients with MVP, the prevalence of MAD was higher (21/24, 88%), mainly driven by a higher prevalence of pseudo-MAD, as the prevalence of true-MAD did not vary significantly in patients with vs without MVP (p = 0.22), except for the inferolateral wall (9/24, 38% vs 20/266, 8%; p < 0.001). The extent of pseudo-MAD was greater in patients with MVP (4.0 [3.0-5.6] mm) than in those without MVP (2.0 [1.5-3.0]; p < 0.001), whereas the extent of true-MAD did not differ significantly (2.5 [2.0-3.2] mm and 1.9 [1.5-2.9] mm; p = 0.06). At the inferolateral wall, the prevalence of pseudo-MAD was 7/24, 29% vs 14/266, 5% (p < 0.001) in patients with vs without MVP.

Conclusion: True-MAD was a common imaging finding in patients undergoing CMR, irrespective of MVP. Patients with MVP showed higher prevalence and extent of pseudo-MAD in all locations and true-MAD in the inferolateral wall.

背景:二尖瓣环状分离(MAD)是一个有争议的实体。最近,已经提出了伪mad和真mad之间的区别,伪mad存在于收缩期和继发于左房壁上翻动的后小叶并置,真mad是指后小叶的插入在舒张期或收缩期都在房壁上移位。我们调查了伪mad和真mad的患病率。方法:这是一项回顾性研究,包括连续的心血管磁共振(CMR)患者。MAD被定义为左心房壁-二尖瓣小叶连接铰链与左心室壁顶部之间≥1mm的位移,从三个长轴视图的cine-CMR图像测量。伪MAD和真MAD分别定义为仅在收缩期或同时在收缩期和舒张期存在MAD。结果:290例患者(59[47-71]岁;包括181名男性(62%)。二尖瓣脱垂(MVP)和MAD分别为24例(8%)和145例(50%),其中真性MAD 100例(35%),假性MAD 45例(16%)。在所有测量中,收缩期MAD程度(2.3 [1.7-3.0]mm)等于或大于舒张期MAD程度(2.0 [1.5-2.9]mm)。最常见的位置是下壁(40%),最罕见的是外壁(17%)。在MVP患者中,MAD的患病率更高(88%),主要是由于伪MAD的患病率更高,因为除了外壁内壁(38%对8%;结论:True-MAD是CMR患者常见的影像学发现,与MVP无关。MVP患者在所有部位的假性mad和外侧壁的真性mad的患病率和程度均较高。
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引用次数: 0
Cardiovascular magnetic resonance in patients with mitral valve prolapse. 二尖瓣脱垂患者的心血管磁共振。
IF 4.2 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-12-25 DOI: 10.1016/j.jocmr.2024.101137
Stefano Figliozzi, Silvana Di Maio, Georgios Georgiopoulos, Bert Vandenberk, Amedeo Chiribiri, Marco Francone, Nay Aung, Steffen E Petersen, Tim Leiner, Jan Bogaert, Pier-Giorgio Masci

With a prevalence of 2-3% in the general population, mitral valve prolapse (MVP) is the most common valvular heart disease. The clinical course is benign in the majority of patients, although severe mitral regurgitation, heart failure, and sudden cardiac death affect a non-negligible subset of patients. Imaging of MVP was confined to echocardiography until a few years ago when it became apparent that cardiovascular magnetic resonance (CMR) could offer comparative advantages for detecting and quantifying mitral valve abnormalities alongside tissue myocardial characterization. The present review highlights the growing body of evidence supporting the role of CMR in patients with MVP. Based on the recent literature, CMR appears not as a simple alternative to echocardiography in patients with poor acoustic windows, but as a complementary imaging modality instrumental for better quantifying mitral valve abnormalities, mitral regurgitation severity, ventricular remodeling, and myocardial tissue changes. In this respect, pivotal CMR studies highlight that mitral annular disjunction and myocardial fibrosis by late gadolinium enhancement are associated with a heightened risk of life-threatening ventricular arrhythmias (arrhythmic MVP). We also delineate how these and other markers (e.g., the severity of mitral regurgitation) could enable a personalized risk assessment in patients with MVP and implement clinical decision-making. Here, we provide a comprehensive review of the current literature, with an emphasis on the arrhythmic MVP phenotype. The review also provides some practical suggestions on how to carry out a dedicated CMR protocol in MVP and composes a thorough report to inform clinicians on key aspects of this valvular heart disease.

二尖瓣脱垂(MVP)是最常见的瓣膜性心脏病,在普通人群中患病率为2-3%。大多数患者的临床过程是良性的,尽管严重的二尖瓣反流、心力衰竭和心源性猝死影响了不可忽视的一部分患者。MVP的成像仅限于超声心动图,直到几年前,心血管磁共振(CMR)在检测和量化二尖瓣异常以及组织心肌表征方面具有比较优势。本综述强调越来越多的证据支持CMR在MVP患者中的作用。根据最近的文献,CMR并不是作为超声心动图的简单替代,而是作为一种辅助成像方式,可以更好地量化二尖瓣异常、二尖瓣反流严重程度、心室重构和心肌组织改变。在这方面,关键的CMR研究强调,晚期钆增强引起的二尖瓣环分离和心肌纤维化与危及生命的室性心律失常(arrhythmic MVP)的风险增加有关。我们还描述了这些和其他标记(例如,二尖瓣反流的严重程度)如何能够对MVP患者进行个性化风险评估并实施临床决策。在这里,我们提供了一个全面的回顾当前的文献,重点是心律失常MVP表型。该综述还就如何在MVP中实施专门的CMR方案提供了一些实用建议,并撰写了一份全面的报告,告知临床医生关于这种瓣瓣性心脏病的关键方面。
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引用次数: 0
Multiparametric cardiovascular magnetic resonance is associated with outcomes in pediatric heart transplant recipients. 多参数心血管磁共振与儿童心脏移植受者的预后相关。
IF 4.2 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-12-25 DOI: 10.1016/j.jocmr.2024.101138
Andrew A Lawson, Kae Watanabe, Lindsay Griffin, Christina Laternser, Michael Markl, Cynthia K Rigsby, Joshua D Robinson, Nazia Husain

Background: Multiparametric cardiovascular magnetic resonance (CMR) has an emerging role in non-invasive surveillance of pediatric heart transplant recipients (PHTR). Higher myocardial T2, higher extracellular volume fraction (ECV), and late gadolinium enhancement (LGE) have been associated with adverse clinical outcomes in adult heart transplant recipients. The purpose of this study was to investigate the prognostic value of CMR-derived T1 and T2 mapping, ECV, and LGE for clinical outcomes in PHTR.

Methods: We performed a single-center, retrospective chart review of consecutive, gadolinium-enhanced CMR studies in PHTR over a 7.5-year period, excluding follow-up studies. Standard CMR ventricular volume and function analysis, T1 mapping with ECV, T2 mapping, and LGE assessment were performed. The composite outcome included cardiac death, non-cardiac death, re-transplantation, and cardiac hospitalization.

Results: Among 113 PHTR, mean age was 13.0 ± 5.1 years, with 6.0 ± 4.0 years since transplant. The indication for CMR was surveillance in 79%. Mean native T1 was 1050 ± 48 ms, T2 49.2 ± 3.9 ms, and ECV 29.7 ± 4.5%. Left ventricular LGE was present in 37% (42/113) and right ventricular LGE in 3.5% (4/113). The mean follow-up time was 2.3 years and median was 1.4 years. Cardiac death occurred in 2% (2/113), re-transplantation in 4% (4/113), and cardiac hospitalization in 22% (25/113). Non-cardiac death did not occur. Using Kaplan-Meier analysis, high T1 (≥1061 ms), T2 (≥50.0 ms), and ECV (≥31.4%) were each associated with decreased freedom from the composite outcome in follow-up. In univariable Cox regression analyses, high T1 was associated with increased risk of the composite outcome (hazard ratios [HR] 4.0, 95% confidence interval [CI] 1.7-9.2, p = 0.001), as were high T2 (HR 2.8, 95% CI 1.1-7.1, p = 0.026), and high ECV (HR 3.5, 95% CI 1.5-8.1, p = 0.004).

Conclusion: T1 and T2 mapping are associated with early differences in adverse cardiac events in PHTR. These data suggest a role for a multicenter study with a longer follow-up duration.

背景:多参数心血管磁共振(CMR)在儿童心脏移植受者(PHTR)的无创监测中发挥着新的作用。在成人心脏移植受者中,较高的心肌T2、较高的细胞外体积分数(ECV)和晚期钆增强(LGE)与不良临床结果相关。本研究的目的是探讨cmr衍生的T1和t2定位、ECV和LGE对PHTR临床结果的预后价值。方法:我们进行了一项单中心、回顾性的图表回顾,包括7.5年期间连续的、钆增强的PHTR CMR研究,不包括随访研究。进行标准CMR心室容积和功能分析、T1与ECV作图、T2作图和LGE评估。复合结局包括心源性死亡、非心源性死亡、再移植和心脏住院。结果:113例PHTR患者平均年龄为13.0±5.1岁,移植后平均年龄为6.0±4.0岁。79%的CMR适应症为监测。平均原生T1为1050±48ms;T2 49.2±3.9ms, ECV 29.7±4.5%。LV LGE占37% (42/113),RV LGE占3.5%(4/113)。平均随访时间2.3年,中位1.4年。心源性死亡占2%(2/113),再移植占4%(4/113),心脏住院占22%(25/113)。未发生非心源性死亡。Kaplan-Meier分析显示,高T1(≥1061ms)、高T2(≥50.0ms)和高ECV(≥31.4%)均与随访中复合结局的自由度降低相关。在单变量Cox回归分析中,高T1与复合结局的风险增加相关(HR 4.0, 95% CI 1.7-9.2, p=0.001),高T2 (HR 2.8, 95% CI 1.1-7.1, p=0.026)和高ECV (HR 3.5, 95% CI 1.5-8.1, p=0.004)。结论:T1和T2定位与PHTR患者不良心脏事件的早期差异有关。这些数据提示多中心研究和较长的随访时间的作用。
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引用次数: 0
Comprehensive prognosis assessment of cardiovascular magnetic resonance parametric mapping in light chain amyloidosis. 轻链淀粉样变性心血管磁共振参数图的综合预后评估。
IF 4.2 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-12-14 DOI: 10.1016/j.jocmr.2024.101135
Xiao Li, Yubo Guo, Kaini Shen, Sisi Huang, Yajuan Gao, Lu Lin, Jian Wang, Jian Cao, Xinxin Cao, Zhengyu Jin, Zhuoli Zhang, Akos Varga-Szemes, U Joseph Schoepf, Jian Li, Yining Wang

Background: Recent evidence underscores the importance of cardiovascular magnetic resonance (CMR) in light chain amyloidosis (AL amyloidosis). We aimed to comprehensively assess the prognostic significance of CMR parametric mapping in AL amyloidosis.

Methods: This prospective study consecutively included AL amyloidosis patients who underwent CMR imaging before therapy. The statistical analyses included T2, extracellular volume, and native T1 as variates under investigation, adjusted for well-established prognostic markers. The outcome was death from any cause.

Results: In total, 195 patients (age, 57.2 ± 9.1 years; male/female, 123/72) were recruited. At the median follow-up time (19 months), the survival probability was approximately 67.2% (131/195). T >44 ms, extracellular volume fraction (ECV) >47%, and native T1 >1468 ms were significantly prognostic (all, P < 0.05) but non-significant after adjustment for N-terminal pro-B-type natriuretic peptide (all, P > 0.05) in AL amyloidosis. T2 >44 ms was independently prognostic after correcting for left ventricle (LV) late gadolinium enhancement, LV ejection fraction, LV longitudinal strain, and therapeutic response (all, P < 0.05). In patients achieving deep hematologic response, T2 >44 ms (hazard ratios [HR] 6.611, 95% confidence interval [CI] 1.723-25.361, P = 0.006) was significantly prognostic for mortality after adjustment for cardiac response. Accordingly, T2 >44 ms was significantly associated with mortality (HR 5.734, 95% CI 1.189-27.656, P = 0.030) and remained independently prognostic after correcting for LV late gadolinium enhancement and LV longitudinal strain (both, P < 0.05) in patients who achieved both deep hematologic response and cardiac response.

Conclusion: This study highlights that T2 is a valuable independent predictor of mortality in an AL amyloidosis population, additive to common CMR risk factors. Moreover, myocardial edema assessment identified patients in need of adjunctive therapies, which is of particular prognostic significance in patients with deep therapeutic response.

背景:最近的证据强调心血管磁共振(CMR)在轻链淀粉样变性(AL淀粉样变性)中的重要性。我们的目的是全面评估CMR参数定位在AL淀粉样变性中的预后意义。方法:本前瞻性研究连续纳入治疗前行CMR成像的AL淀粉样变性患者。统计分析包括T2、细胞外体积和原生T1作为调查变量,并根据已建立的预后标志物进行调整。结果是死于任何原因。结果:共195例患者(年龄57.2±9.1岁;男性/女性,123/72)被招募。中位随访时间(19个月),生存率约为67.2%。T2 bbb444 ms、ECV bbb47 %、原生T1 >468 ms对AL淀粉样变性的预后有显著影响(均P < 0.05),但调整NT-proBNP后无显著影响(均P >.05)。校正左心室LGE、左室射血分数、左室纵向应变和治疗反应后,T2 bbb44 ms是独立预后因素(全部,p44 ms (HR 6.611, 95% CI 1.723-25.361, P=0.006)是校正心脏反应后死亡率的显著预后因素。因此,T2 bbbb44 ms与死亡率显著相关(HR 5.734, 95% CI 1.189-27.656, P=0.030),并且在校正左室晚期钆增强和左室纵向应变后仍然是独立的预后因素(两者均为P)。结论:本研究强调T2是AL淀粉样变性人群中有价值的独立预测因子,加上常见的CMR危险因素。此外,心肌水肿评估确定了需要辅助治疗的患者,这对治疗反应较深的患者具有特别的预后意义。
{"title":"Comprehensive prognosis assessment of cardiovascular magnetic resonance parametric mapping in light chain amyloidosis.","authors":"Xiao Li, Yubo Guo, Kaini Shen, Sisi Huang, Yajuan Gao, Lu Lin, Jian Wang, Jian Cao, Xinxin Cao, Zhengyu Jin, Zhuoli Zhang, Akos Varga-Szemes, U Joseph Schoepf, Jian Li, Yining Wang","doi":"10.1016/j.jocmr.2024.101135","DOIUrl":"10.1016/j.jocmr.2024.101135","url":null,"abstract":"<p><strong>Background: </strong>Recent evidence underscores the importance of cardiovascular magnetic resonance (CMR) in light chain amyloidosis (AL amyloidosis). We aimed to comprehensively assess the prognostic significance of CMR parametric mapping in AL amyloidosis.</p><p><strong>Methods: </strong>This prospective study consecutively included AL amyloidosis patients who underwent CMR imaging before therapy. The statistical analyses included T2, extracellular volume, and native T1 as variates under investigation, adjusted for well-established prognostic markers. The outcome was death from any cause.</p><p><strong>Results: </strong>In total, 195 patients (age, 57.2 ± 9.1 years; male/female, 123/72) were recruited. At the median follow-up time (19 months), the survival probability was approximately 67.2% (131/195). T >44 ms, extracellular volume fraction (ECV) >47%, and native T1 >1468 ms were significantly prognostic (all, P < 0.05) but non-significant after adjustment for N-terminal pro-B-type natriuretic peptide (all, P > 0.05) in AL amyloidosis. T2 >44 ms was independently prognostic after correcting for left ventricle (LV) late gadolinium enhancement, LV ejection fraction, LV longitudinal strain, and therapeutic response (all, P < 0.05). In patients achieving deep hematologic response, T2 >44 ms (hazard ratios [HR] 6.611, 95% confidence interval [CI] 1.723-25.361, P = 0.006) was significantly prognostic for mortality after adjustment for cardiac response. Accordingly, T2 >44 ms was significantly associated with mortality (HR 5.734, 95% CI 1.189-27.656, P = 0.030) and remained independently prognostic after correcting for LV late gadolinium enhancement and LV longitudinal strain (both, P < 0.05) in patients who achieved both deep hematologic response and cardiac response.</p><p><strong>Conclusion: </strong>This study highlights that T2 is a valuable independent predictor of mortality in an AL amyloidosis population, additive to common CMR risk factors. Moreover, myocardial edema assessment identified patients in need of adjunctive therapies, which is of particular prognostic significance in patients with deep therapeutic response.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101135"},"PeriodicalIF":4.2,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11773017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing microvascular dysfunction and predicting long-term prognosis in patients with cardiac amyloidosis by cardiovascular magnetic resonance quantitative stress perfusion. 通过CMR定量应力灌注评估心脏淀粉样变性患者的微血管功能障碍并预测长期预后
IF 4.2 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-12-14 DOI: 10.1016/j.jocmr.2024.101134
Leting Tang, Wenjin Zhao, Kang Li, Lin Tian, Xiaoyue Zhou, Hu Guo, Mu Zeng

Background: Cardiac involvement in light chain amyloidosis (AL) is the main determinant of prognosis. Amyloid can be deposited in the extracellular space and cause an increase in extracellular volume fraction (ECV). At the same time, amyloid can also be deposited in the wall of small vessels and cause microvascular dysfunction. This study sought to investigate the extent of microvascular dysfunction and its incremental prognostic value in cardiac light-chain amyloidosis (AL-CA) by quantitative stress perfusion.

Methods: A total of 126 AL amyloidosis patients (61.13 ± 8.46 years, 81 male) confirmed by pathology were prospectively recruited. All subjects underwent cardiovascular magnetic resonance (CMR) with late gadolinium enhancement (LGE), T1 mapping, and stress perfusion on a 3T scanner. ECV and myocardial perfusion reserve (MPR) were measured semi-automatically using a dedicated CMR software. Clinical, laboratory, and CMR parameters were analyzed for their prognostic value in the assessment of AL-CA patients. Mortality-associated markers were analyzed by univariate and multivariable Cox regression.

Results: The median follow-up time was 37 (33.6-40.4) months, and 62 patients died. The ECV of survivors was significantly reduced, but the stress myocardial blood flow and MPR were higher (P < 0.001). The MPR of the transmural LGE group was significantly lower than that of the no LGE and subendocardial LGE groups (P < 0.001). In multivariable analysis, ECV, MPR, and LGE were independently predictive. MPR of >1.5 and ECV of ≤53.6% were associated with improved overall survival, both of which provided predictive incremental value in patients with advanced disease. With equal Mayo staging and degree of ECV, MPR improves assessment of patient survival.

Conclusion: ECV and MPR showed additive incremental values and further discriminated prognosis of patients in advanced stages. CMR phenotypes with higher ECV and lower MPR had a worse prognosis.

背景:轻链(AL)淀粉样变累及心脏是影响预后的主要因素。淀粉样蛋白可沉积在细胞外空间并引起细胞外体积(ECV)的增加。同时,淀粉样蛋白还可沉积在小血管壁上,引起微血管功能障碍。本研究旨在通过定量应激灌注探讨心脏轻链淀粉样变性(AL-CA)微血管功能障碍的程度及其增量预后价值。方法:前瞻性招募经病理证实的AL淀粉样变性患者126例(61.13±8.46岁,男性81例)。所有受试者均在3T扫描仪上进行心血管磁共振(CMR)、晚期钆增强(LGE)、T1定位和应激灌注。采用专用CMR软件半自动测量ECV和心肌灌注储备(MPR)。分析临床、实验室和CMR参数在评估AL-CA患者预后中的价值。采用单因素和多因素Cox回归分析死亡率相关指标。结果:中位随访时间为37(33.6 ~ 40.4)个月,死亡62例。幸存者的ECV明显降低,但应激心肌血流量和MPR升高(P < 0.001)。经壁LGE组的MPR显著低于无LGE和心内膜下LGE组(P < 0.001)。在多变量分析中,ECV、MPR和LGE具有独立预测作用。MPR为bbb1.5, ECV≤53.6%与总生存期改善相关,这两项指标对晚期患者具有预测增量价值。在Mayo分期和ECV程度相同的情况下,MPR还可以进一步评估患者的生存。结论:ECV和MPR具有累加性增量值,可进一步区分晚期患者的预后。高ECV和低MPR的CMR表型预后较差。
{"title":"Assessing microvascular dysfunction and predicting long-term prognosis in patients with cardiac amyloidosis by cardiovascular magnetic resonance quantitative stress perfusion.","authors":"Leting Tang, Wenjin Zhao, Kang Li, Lin Tian, Xiaoyue Zhou, Hu Guo, Mu Zeng","doi":"10.1016/j.jocmr.2024.101134","DOIUrl":"10.1016/j.jocmr.2024.101134","url":null,"abstract":"<p><strong>Background: </strong>Cardiac involvement in light chain amyloidosis (AL) is the main determinant of prognosis. Amyloid can be deposited in the extracellular space and cause an increase in extracellular volume fraction (ECV). At the same time, amyloid can also be deposited in the wall of small vessels and cause microvascular dysfunction. This study sought to investigate the extent of microvascular dysfunction and its incremental prognostic value in cardiac light-chain amyloidosis (AL-CA) by quantitative stress perfusion.</p><p><strong>Methods: </strong>A total of 126 AL amyloidosis patients (61.13 ± 8.46 years, 81 male) confirmed by pathology were prospectively recruited. All subjects underwent cardiovascular magnetic resonance (CMR) with late gadolinium enhancement (LGE), T1 mapping, and stress perfusion on a 3T scanner. ECV and myocardial perfusion reserve (MPR) were measured semi-automatically using a dedicated CMR software. Clinical, laboratory, and CMR parameters were analyzed for their prognostic value in the assessment of AL-CA patients. Mortality-associated markers were analyzed by univariate and multivariable Cox regression.</p><p><strong>Results: </strong>The median follow-up time was 37 (33.6-40.4) months, and 62 patients died. The ECV of survivors was significantly reduced, but the stress myocardial blood flow and MPR were higher (P < 0.001). The MPR of the transmural LGE group was significantly lower than that of the no LGE and subendocardial LGE groups (P < 0.001). In multivariable analysis, ECV, MPR, and LGE were independently predictive. MPR of >1.5 and ECV of ≤53.6% were associated with improved overall survival, both of which provided predictive incremental value in patients with advanced disease. With equal Mayo staging and degree of ECV, MPR improves assessment of patient survival.</p><p><strong>Conclusion: </strong>ECV and MPR showed additive incremental values and further discriminated prognosis of patients in advanced stages. CMR phenotypes with higher ECV and lower MPR had a worse prognosis.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101134"},"PeriodicalIF":4.2,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11761856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Wide variation in shape of hypoplastic left ventricles undergoing recruitment and biventricular repair: A statistical shape modeling study. 发育不全左心室在再植和双心室修复过程中形态的广泛变化:一项统计形态模型研究。
IF 4.2 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-12-06 DOI: 10.1016/j.jocmr.2024.101131
Isabel R Barnet, Noah E Schulz, Sunil J Ghelani, David M Hoganson, Eric N Feins, Peter E Hammer, Sitaram M Emani, Lynn A Sleeper, Rebecca S Beroukhim

Background: Patients with hypoplastic left ventricles (LV) who undergo volume-loading procedures (recruitment, biventricular [BIV] repair) are at risk for adverse outcomes, including heart failure and death. We investigated pre-BIV LV shape as a predictor of outcome after BIV repair in patients with hypoplastic LVs.

Methods: Baseline and post-recruitment cardiac magnetic resonance imaging and computed tomography data were analyzed in patients with hypoplastic LV (<50 mL/m2). Statistical shape modeling (SSM) was utilized to generate a model of the shape and variability of LVs. Traditional measures of LV sphericity and eccentricity were also measured. Major adverse cardiovascular events (MACE) included heart failure, transplant, and death.

Results: Of 95 patients with baseline mean LV volume 29 ± 13 mL/m2, 45/95 (47%) had a right dominant atrioventricular canal defect, 31/95 (33%) had a variant of hypoplastic left heart syndrome, and 18/95 (19%) had endocardial fibroelastosis (EFE). A wide variation in LV shape was found by SSM, and shape modes were associated with right ventricle (RV) and LV size, and diagnosis. BIV repair was achieved in 74/95 (78%) patients; 13/74 (18%) of BIV patients had MACE. Predictors of MACE following BIV repair included EFE, higher RV mass index, and higher RV end-diastolic volume index. No baseline or post-recruitment LV shape parameter was associated with the outcome after BIV repair.

Conclusion: The shape model of hypoplastic LVs demonstrated a wide array of LV shapes. LVs gained sphericity and size and lost eccentricity with recruitment. Though the ventricles changed shape with recruitment, no specific LV shape characteristic at the baseline or post-recruitment stage was predictive of decision to proceed with BIV repair or outcome. Higher RV mass and volume may represent new biomarkers that predict outcomes following BIV repair in patients with hypoplastic LV. Further investigation could determine the reproducibility of these findings.

背景:左心室发育不全(LV)患者在接受容量负荷手术(招募、双心室(BIV)修复)时,有发生包括心力衰竭和死亡在内的不良后果的风险。我们研究了在发育不全的LV患者中,BIV前LV形状作为BIV修复后预后的预测因子。方法:分析左室发育不全(< 50 ml/m2)患者的基线和招募后心脏MRI和CT数据。利用统计形状模型(SSM)建立了lv的形状和变异性模型。还测量了LV球度和偏心率的传统测量方法。主要心脏不良事件(MACE)包括心力衰竭、移植和死亡。结果:95例基线平均左室容积为29±13ml/m2的患者中,45例(47%)有右侧优势房室管缺损,31例(34%)有左心发育不全综合征变型,18例(19%)有心内膜纤维弹性增生(EFE)。SSM发现左室形状变化很大,形状模式与左室和左室大小以及诊断相关。74例(78%)患者实现了BIV修复;13例(18%)BIV患者有MACE。BIV修复后MACE的预测因子包括EFE、较高的右心室质量指数和较高的右心室舒张末期容积指数。没有基线或招募后的左室形状参数与BIV修复后的结果相关。结论:发育不全的左室形态模型显示出广泛的左室形态。LVs增加了球形度和大小,并失去了偏心率。尽管心室形状随着再灌注而改变,但在基线或再灌注后阶段没有特定的左室形状特征可预测是否进行BIV修复或预后。较高的左室质量和体积可能是预测左室发育不全患者BIV修复后预后的新生物标志物。进一步的调查可以确定这些发现的可重复性。
{"title":"Wide variation in shape of hypoplastic left ventricles undergoing recruitment and biventricular repair: A statistical shape modeling study.","authors":"Isabel R Barnet, Noah E Schulz, Sunil J Ghelani, David M Hoganson, Eric N Feins, Peter E Hammer, Sitaram M Emani, Lynn A Sleeper, Rebecca S Beroukhim","doi":"10.1016/j.jocmr.2024.101131","DOIUrl":"10.1016/j.jocmr.2024.101131","url":null,"abstract":"<p><strong>Background: </strong>Patients with hypoplastic left ventricles (LV) who undergo volume-loading procedures (recruitment, biventricular [BIV] repair) are at risk for adverse outcomes, including heart failure and death. We investigated pre-BIV LV shape as a predictor of outcome after BIV repair in patients with hypoplastic LVs.</p><p><strong>Methods: </strong>Baseline and post-recruitment cardiac magnetic resonance imaging and computed tomography data were analyzed in patients with hypoplastic LV (<50 mL/m<sup>2</sup>). Statistical shape modeling (SSM) was utilized to generate a model of the shape and variability of LVs. Traditional measures of LV sphericity and eccentricity were also measured. Major adverse cardiovascular events (MACE) included heart failure, transplant, and death.</p><p><strong>Results: </strong>Of 95 patients with baseline mean LV volume 29 ± 13 mL/m<sup>2</sup>, 45/95 (47%) had a right dominant atrioventricular canal defect, 31/95 (33%) had a variant of hypoplastic left heart syndrome, and 18/95 (19%) had endocardial fibroelastosis (EFE). A wide variation in LV shape was found by SSM, and shape modes were associated with right ventricle (RV) and LV size, and diagnosis. BIV repair was achieved in 74/95 (78%) patients; 13/74 (18%) of BIV patients had MACE. Predictors of MACE following BIV repair included EFE, higher RV mass index, and higher RV end-diastolic volume index. No baseline or post-recruitment LV shape parameter was associated with the outcome after BIV repair.</p><p><strong>Conclusion: </strong>The shape model of hypoplastic LVs demonstrated a wide array of LV shapes. LVs gained sphericity and size and lost eccentricity with recruitment. Though the ventricles changed shape with recruitment, no specific LV shape characteristic at the baseline or post-recruitment stage was predictive of decision to proceed with BIV repair or outcome. Higher RV mass and volume may represent new biomarkers that predict outcomes following BIV repair in patients with hypoplastic LV. Further investigation could determine the reproducibility of these findings.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101131"},"PeriodicalIF":4.2,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11780089/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex differences and determinants of coronary microvascular function in asymptomatic adults with type 2 diabetes. 无症状2型糖尿病成人冠状动脉微血管功能的性别差异和决定因素
IF 4.2 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-12-06 DOI: 10.1016/j.jocmr.2024.101132
Jian L Yeo, Abhishek Dattani, Joanna M Bilak, Alice L Wood, Lavanya Athithan, Aparna Deshpande, Anvesha Singh, J Ranjit Arnold, Emer M Brady, David Adlam, John D Biglands, Peter Kellman, Hui Xue, Thomas Yates, Melanie J Davies, Gaurav S Gulsin, Gerry P McCann

Background: Coronary microvascular dysfunction (CMD) is a significant complication in type 2 diabetes (T2D) and may be more common in women. We aimed to evaluate the sex differences and sex-specific clinical determinants of CMD in adults with T2D without prevalent cardiovascular disease.

Methods: Single center pooled analysis of four prospective studies comparing asymptomatic people with T2D and controls. All subjects underwent comprehensive cardiovascular phenotyping with myocardial perfusion reserve (MPR) quantified with perfusion cardiovascular magnetic resonance (CMR). Participants with silent coronary disease were excluded. Multivariable linear regression was performed to identify determinants of MPR with an interaction term for sex.

Results: Four hundred and seventy-nine T2D (age 57 ± 11 years, 42% [202/479] women) were compared with 116 controls (age 53 ± 11 years, 41% [48/116] women). Men with T2D, but not women, demonstrated worse systolic function and higher extracellular volume fraction than controls. MPR was significantly lower in T2D than controls (women, 2.6 ± 0.9 vs 3.3 ± 1.0, p < 0.001; men, 3.1 ± 0.9 vs 3.5 ± 1.0, p = 0.004), and lower in women than men with T2D (p < 0.001). More women than men with T2D had MPR <2.5 (46% [79/202] vs 26% [64/277], p < 0.001). There was a significant interaction between sex and body mass index (BMI) for MPR (p interaction <0.001). Following adjustment for clinical risk factors, inverse association with MPR were BMI in women (β = -0.17, p = 0.045) and systolic blood pressure in men (β = -0.14, p = 0.049).

Conclusion: Among asymptomatic adults with T2D, women had a greater prevalence of CMD than men. Risk factors modestly but significantly associated with CMD in asymptomatic people with T2D were BMI among women and systolic blood pressure among men.

背景:冠状动脉微血管功能障碍(CMD)是2型糖尿病(T2D)的重要并发症,可能在女性中更为常见。我们的目的是评估没有流行心血管疾病的成年T2D患者CMD的性别差异和性别特异性临床决定因素。方法:对四项前瞻性研究进行单中心汇总分析,比较无症状T2D患者和对照组。所有受试者都进行了全面的心血管表型分析,心肌灌注储备(MPR)用灌注MRI量化。排除无症状冠状动脉疾病的参与者。进行多变量线性回归以确定MPR的决定因素与性别的相互作用项。结果:479例T2D患者(年龄57±11y,女性42%)与116例对照(年龄53±11y,女性41%)。与对照组相比,男性T2D患者表现出更差的收缩功能和更高的细胞外体积分数,而女性没有。T2D患者的MPR明显低于对照组(女性,2.6±0.9 vs 3.3±1.0,p)。结论:在无症状T2D成人中,女性的CMD患病率高于男性。与无症状T2D患者冠状动脉微血管功能障碍相关的危险因素是女性的BMI和男性的收缩压。
{"title":"Sex differences and determinants of coronary microvascular function in asymptomatic adults with type 2 diabetes.","authors":"Jian L Yeo, Abhishek Dattani, Joanna M Bilak, Alice L Wood, Lavanya Athithan, Aparna Deshpande, Anvesha Singh, J Ranjit Arnold, Emer M Brady, David Adlam, John D Biglands, Peter Kellman, Hui Xue, Thomas Yates, Melanie J Davies, Gaurav S Gulsin, Gerry P McCann","doi":"10.1016/j.jocmr.2024.101132","DOIUrl":"10.1016/j.jocmr.2024.101132","url":null,"abstract":"<p><strong>Background: </strong>Coronary microvascular dysfunction (CMD) is a significant complication in type 2 diabetes (T2D) and may be more common in women. We aimed to evaluate the sex differences and sex-specific clinical determinants of CMD in adults with T2D without prevalent cardiovascular disease.</p><p><strong>Methods: </strong>Single center pooled analysis of four prospective studies comparing asymptomatic people with T2D and controls. All subjects underwent comprehensive cardiovascular phenotyping with myocardial perfusion reserve (MPR) quantified with perfusion cardiovascular magnetic resonance (CMR). Participants with silent coronary disease were excluded. Multivariable linear regression was performed to identify determinants of MPR with an interaction term for sex.</p><p><strong>Results: </strong>Four hundred and seventy-nine T2D (age 57 ± 11 years, 42% [202/479] women) were compared with 116 controls (age 53 ± 11 years, 41% [48/116] women). Men with T2D, but not women, demonstrated worse systolic function and higher extracellular volume fraction than controls. MPR was significantly lower in T2D than controls (women, 2.6 ± 0.9 vs 3.3 ± 1.0, p < 0.001; men, 3.1 ± 0.9 vs 3.5 ± 1.0, p = 0.004), and lower in women than men with T2D (p < 0.001). More women than men with T2D had MPR <2.5 (46% [79/202] vs 26% [64/277], p < 0.001). There was a significant interaction between sex and body mass index (BMI) for MPR (p interaction <0.001). Following adjustment for clinical risk factors, inverse association with MPR were BMI in women (β = -0.17, p = 0.045) and systolic blood pressure in men (β = -0.14, p = 0.049).</p><p><strong>Conclusion: </strong>Among asymptomatic adults with T2D, women had a greater prevalence of CMD than men. Risk factors modestly but significantly associated with CMD in asymptomatic people with T2D were BMI among women and systolic blood pressure among men.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101132"},"PeriodicalIF":4.2,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11761338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mean pulmonary artery pressure prediction with explainable multi-view cardiovascular magnetic resonance cine series deep learning model. 用可解释的多视点心脏MR系列深度学习模型预测平均肺动脉压。
IF 4.2 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-12-05 DOI: 10.1016/j.jocmr.2024.101133
Li-Hsin Cheng, Xiaowu Sun, Charlie Elliot, Robin Condliffe, David G Kiely, Samer Alabed, Andrew J Swift, Rob J van der Geest

Background: Pulmonary hypertension (PH) is a heterogeneous condition and regardless of etiology impacts negatively on survival. Diagnosis of PH is based on hemodynamic parameters measured invasively at right heart catheterization (RHC); however, a non-invasive alternative would be clinically valuable. Our aim was to estimate RHC parameters non-invasively from cardiac magnetic resonance (MR) data using deep learning models and to identify key contributing imaging features.

Methods: We constructed an explainable convolutional neural network (CNN) taking cardiac MR cine series from four different views as input to predict mean pulmonary artery pressure (mPAP). The model was trained and evaluated on 1646 examinations. The model's attention weight and predictive performance associated with each frame, view, or phase were used to judge its importance. Additionally, the importance of each cardiac chamber was inferred by perturbing part of the input pixels.

Results: The model achieved a Pearson correlation coefficient of 0.80 and R2 of 0.64 in predicting mPAP and identified the right ventricle region on short-axis view to be especially informative.

Conclusion: Hemodynamic parameters can be estimated non-invasively with a CNN, using MR cine series from four views, revealing key contributing features at the same time.

背景:肺动脉高压(PH)是一种异质性疾病,与病因无关,对生存有负面影响。PH的诊断是基于右心导管(RHC)有创性测量的血液动力学参数,然而,一种无创的替代方法将具有临床价值。我们的目的是使用深度学习模型从心脏MR数据中无创地估计RHC参数,并确定关键的成像特征。方法:以4种不同视角的心脏MR影像序列为输入,构建可解释卷积神经网络(CNN)预测平均肺动脉压(mPAP)。该模型在1646次考试中进行了训练和评估。模型的关注权重和与每个帧、视图或阶段相关的预测性能被用来判断其重要性。此外,通过干扰输入像素的一部分来推断每个心腔的重要性。结果:该模型预测mPAP的Pearson相关系数(PCC)为0.80,R2为0.64,并在短轴(SAX)视图上识别出右心室(RV)区域的信息特别丰富。结论:利用4个视点的MR影像序列,CNN可以无创地估计血流动力学参数,同时揭示关键的贡献特征。
{"title":"Mean pulmonary artery pressure prediction with explainable multi-view cardiovascular magnetic resonance cine series deep learning model.","authors":"Li-Hsin Cheng, Xiaowu Sun, Charlie Elliot, Robin Condliffe, David G Kiely, Samer Alabed, Andrew J Swift, Rob J van der Geest","doi":"10.1016/j.jocmr.2024.101133","DOIUrl":"10.1016/j.jocmr.2024.101133","url":null,"abstract":"<p><strong>Background: </strong>Pulmonary hypertension (PH) is a heterogeneous condition and regardless of etiology impacts negatively on survival. Diagnosis of PH is based on hemodynamic parameters measured invasively at right heart catheterization (RHC); however, a non-invasive alternative would be clinically valuable. Our aim was to estimate RHC parameters non-invasively from cardiac magnetic resonance (MR) data using deep learning models and to identify key contributing imaging features.</p><p><strong>Methods: </strong>We constructed an explainable convolutional neural network (CNN) taking cardiac MR cine series from four different views as input to predict mean pulmonary artery pressure (mPAP). The model was trained and evaluated on 1646 examinations. The model's attention weight and predictive performance associated with each frame, view, or phase were used to judge its importance. Additionally, the importance of each cardiac chamber was inferred by perturbing part of the input pixels.</p><p><strong>Results: </strong>The model achieved a Pearson correlation coefficient of 0.80 and R<sup>2</sup> of 0.64 in predicting mPAP and identified the right ventricle region on short-axis view to be especially informative.</p><p><strong>Conclusion: </strong>Hemodynamic parameters can be estimated non-invasively with a CNN, using MR cine series from four views, revealing key contributing features at the same time.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101133"},"PeriodicalIF":4.2,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11782807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Feasibility of fetal cardiac function and anatomy assessment by real-time spiral balanced steady-state free precession magnetic resonance imaging at 0.55T. 0.55T实时螺旋bSSFP MRI对胎儿心功能及解剖评估的可行性。
IF 4.2 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-12-03 DOI: 10.1016/j.jocmr.2024.101130
Ye Tian, Jon Detterich, Jay D Pruetz, Ecrin Yagiz, John C Wood, Krishna S Nayak

Background: Contemporary 0.55T magnetic resonance imaging (MRI) is promising for fetal MRI, due to the larger bore, reduced safety concerns, lower acoustic noise, and improved fast imaging capability. In this work, we explore improved fetal cardiovascular magnetic resonance (CMR) without relying on any synchronizing devices, prospective, or retrospective gating, to determine the feasibility of real-time MRI evaluation of fetal cardiac function as well as cardiac and great vessel anatomies by using spiral balanced steady-state free precession (bSSFP) at 0.55T.

Methods: A real-time spiral bSSFP pulse sequence for fetal CMR was implemented and optimized on a 0.55T whole-body MRI. Fetal CMR was prospectively performed between May 2022 and August 2023. The protocol included (1) real-time images at standard cardiac views, for 10-20 s/view and 40-43.6 ms/frame and (2) 4-9 stacks of slices at standard cardiac views that each cover the whole heart, with 15-30 slices/stack, and 2-5 s/slice, at 320-349 ms/frame. Images were evaluated by a fetal cardiologist. Quantitative measurements of cardiothoracic area ratio and cardiac axis were compared with previous reports. Diagnostic accuracy was compared against postnatal echocardiographic findings.

Results: Twenty-nine participants were enrolled for 32 CMR exams, with mean maternal age 33.6 ± 5.8 years (range 22-44 years) and mean gestational age 32.8 ± 3.9 weeks (range 23-38 weeks). The proposed sequence enabled evaluation of the fetal heart in <30 min in all cases (average 22 min). Real-time MRI allowed easy adjustment of scan plan, automatic whole-heart volumetric sweeping, and flexible choice of reconstruction temporal resolution. For key cardiac anatomic features, 60% (315/527) were delineated well. Mean cardiothoracic area ratio and cardiac axis were 0.27 ± 0.04 and 45.8 ± 7.8 degrees. Diagnostic agreement with postnatal echocardiographic findings was 84% (26/31).

Conclusion: A spiral real-time bSSFP pulse sequence at 0.55T can provide both low-framerate and high-framerate fetal heart images without relying on maternal breath-hold, specialized gating devices, or cardiac gating. The low-framerate images offer high diagnostic quality structural evaluations of the fetal heart, while the high-framerate images capture fetal heart motion and may enable functional assessments.

背景:当代0.55T MRI在胎儿MRI中很有前景,因为它具有更大的孔径、更少的安全隐患、更低的噪声和更高的快速成像能力。在这项工作中,我们探索改进的胎儿心脏MRI (CMR)不依赖于任何同步装置,前瞻性,或回顾性门控。目的:探讨螺旋平衡稳态自由进动(bSSFP)在0.55T下实时MRI评价胎儿心功能及心脏和大血管解剖的可行性。方法:在0.55T全身MRI上实现并优化胎儿CMR实时螺旋bSSFP脉冲序列。胎儿CMR在2022年5月至2023年8月期间前瞻性进行。该方案包括:1)标准心脏视图的实时图像,10-20秒/视图,40 - 43.6毫秒/帧;2)标准心脏视图的4-9层切片,每个覆盖整个心脏,15-30层/层,2-5秒/层,320 - 349毫秒/帧。图像由胎儿心脏病专家评估。将胸廓面积比和心轴的定量测量与以往的报道进行比较。将诊断准确性与产后超声心动图结果进行比较。结果:29名参与者参加了32次CMR检查,平均母亲年龄33.6±5.8岁(范围22-44岁),平均胎龄32.8±3.9周(范围23-38周)。结论:0.55T的螺旋实时bSSFP脉冲序列可以提供低帧率和高帧率的胎儿心脏图像,而不依赖于母体屏气、专门的门控装置或心脏门控。低帧率图像提供高诊断质量的胎心结构评估,而高帧率图像捕捉胎心运动,并可能进行功能评估。
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引用次数: 0
Improving the efficiency and accuracy of cardiovascular magnetic resonance with artificial intelligence-review of evidence and proposition of a roadmap to clinical translation. 利用人工智能提高 CMR 的效率和准确性--证据回顾与临床转化路线图建议。
IF 4.2 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-12-01 Epub Date: 2024-06-22 DOI: 10.1016/j.jocmr.2024.101051
Qiang Zhang, Anastasia Fotaki, Sona Ghadimi, Yu Wang, Mariya Doneva, Jens Wetzl, Jana G Delfino, Declan P O'Regan, Claudia Prieto, Frederick H Epstein

Background: Cardiovascular magnetic resonance (CMR) is an important imaging modality for the assessment of heart disease; however, limitations of CMR include long exam times and high complexity compared to other cardiac imaging modalities. Recently advancements in artificial intelligence (AI) technology have shown great potential to address many CMR limitations. While the developments are remarkable, translation of AI-based methods into real-world CMR clinical practice remains at a nascent stage and much work lies ahead to realize the full potential of AI for CMR.

Methods: Herein we review recent cutting-edge and representative examples demonstrating how AI can advance CMR in areas such as exam planning, accelerated image reconstruction, post-processing, quality control, classification and diagnosis.

Results: These advances can be applied to speed up and simplify essentially every application including cine, strain, late gadolinium enhancement, parametric mapping, 3D whole heart, flow, perfusion and others. AI is a unique technology based on training models using data. Beyond reviewing the literature, this paper discusses important AI-specific issues in the context of CMR, including (1) properties and characteristics of datasets for training and validation, (2) previously published guidelines for reporting CMR AI research, (3) considerations around clinical deployment, (4) responsibilities of clinicians and the need for multi-disciplinary teams in the development and deployment of AI in CMR, (5) industry considerations, and (6) regulatory perspectives.

Conclusions: Understanding and consideration of all these factors will contribute to the effective and ethical deployment of AI to improve clinical CMR.

心血管磁共振(CMR)是评估心脏病的一种重要成像模式;然而,与其他心脏成像模式相比,CMR 存在检查时间长、复杂性高等局限性。最近,人工智能(AI)技术的进步显示出解决 CMR 许多局限性的巨大潜力。虽然这些发展令人瞩目,但将基于人工智能的方法转化为现实世界中的 CMR 临床实践仍处于起步阶段,要充分发挥人工智能在 CMR 方面的潜力还有很多工作要做。在此,我们将回顾最近的前沿和代表性案例,展示人工智能如何在检查计划、加速图像重建、后处理、质量控制、分类和诊断等领域推动 CMR 的发展。这些进步可用于加快和简化各种应用,包括电影、应变、后期钆增强、参数图、三维全心、血流、灌注等。人工智能是一种基于数据训练模型的独特技术。除了回顾文献外,本文还讨论了 CMR 中重要的人工智能特定问题,包括:(1) 用于训练和验证的数据集的属性和特征;(2) 以前发布的 CMR 人工智能研究报告指南;(3) 临床部署方面的考虑因素;(4) 临床医生的责任以及在 CMR 中开发和部署人工智能时多学科团队的必要性;(5) 行业考虑因素;(6) 监管角度。了解和考虑所有这些因素将有助于有效和合乎道德地部署人工智能,以改善临床 CMR。
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引用次数: 0
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Journal of Cardiovascular Magnetic Resonance
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