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Late gadolinium enhancement and the diagnosis of arrhythmogenic right ventricular cardiomyopathy. 晚期钆增强与 ARVC 诊断。
IF 4.2 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-07-31 DOI: 10.1016/j.jocmr.2024.101075
David A Bluemke
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引用次数: 0
Reduced response to regadenoson with increased weight: An artificial intelligence-based quantitative myocardial perfusion study. 体重增加会降低对雷公藤多苷的反应:基于人工智能的定量心肌灌注研究。
IF 4.2 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-07-25 DOI: 10.1016/j.jocmr.2024.101066
Emmanouil Androulakis, Georgios Georgiopoulos, Alessia Azzu, Elena Surkova, Adam Bakula, Panagiotis Papagkikas, Alexandros Briasoulis, Ranil De Silva, Peter Kellman, Dudley Pennell, Francisco Alpendurada

Background: There is conflicting evidence regarding the response to a fixed dose of regadenoson in patients with high body weight. The aim of this study was to evaluate the effectiveness of regadenoson in patients with varying body weights using novel quantitative cardiovascular magnetic resonance (CMR) perfusion parameters in addition to standard clinical markers.

Methods: Consecutive patients with typical angina and/or risk factors for coronary artery disease (N = 217) underwent regadenoson stress CMR perfusion imaging using a dual-sequence quantitative protocol with perfusion parameters generated from an artificial intelligence (AI)-based algorithm. CMR was performed on 1.5T scanners using a standard 0.4 mg injection of regadenoson. A cohort of consecutive patients undergoing adenosine stress perfusion (N = 218) was used as a control group.

Results: An inverse association of myocardial perfusion reserve and weight (mean decrease -0.05 per 10 kg increase, 95% confidence interval [CI] -0.009/-0.0001, P = 0.045) was noted in the regadenoson group but not in patients stressed with adenosine (P = 0.77). Adjusted logistic regression analysis revealed a 10 kg increase resulted in 36% increased odds for inadequate stress response (odds ratio [OR] = 1.36, 95% CI 1.10-1.69, P = 0.005). Moreover, a significant interaction (OR = 1.09, 95% CI 1.02-1.16, P = 0.012) between stressor type (regadenoson vs adenosine) and weight was noted. This was also confirmed in the propensity-matched subgroup (P = 0.024) and was not attenuated after adjustment (P = 0.041). Body surface area (BSA) (P = 0.006) but not body mass index (P = 0.055) was differentially associated with inadequate response conditional to the stressor used, and this association remained significant after adjustment for confounders (P = 0.025). Patients in the highest quartile of weight (>93 kg) or BSA (>2.06 m2) had substantially increased odds for inadequate response with regadenoson (OR = 8.19, 95% CI 2.04-32.97, P = 0.003 for increased weight and OR = 7.75, 95% CI 1.93-31.13, P = 0.004 for increased BSA). Both weight and BSA had excellent discriminative ability for inadequate regadenoson response (receiver operating characteristic area under curves 0.84 and 0.83, respectively).

Conclusion: Using quantitative perfusion CMR in patients undergoing pharmacological stress with regadenoson, we found an inverse relationship between patient weight and both clinical response and myocardial perfusion parameters. A fixed-dose bolus approach may not be adequate to induce maximal hyperemia in patients with increased weight. Weight-adjusted stressors, such as adenosine, may be considered instead in patients with body weight >93 kg and BSA >2.06 m2.

背景:关于高体重患者对固定剂量瑞格列奈松的反应,存在相互矛盾的证据。本研究旨在评估雷加地诺松对不同体重患者的疗效,除了使用标准临床指标外,还使用了新型定量 CMR 灌注参数:具有典型心绞痛和/或冠状动脉疾病危险因素的连续患者(217 人)接受了雷加地诺松应激 CMR 灌注成像,该成像采用双序列定量方案,灌注参数由基于人工智能(AI)的算法生成。CMR 在 1.5T 扫描仪上进行,使用标准的 0.4 毫克瑞格列酮注射液。一组连续接受腺苷应激灌注的患者(N=218)作为对照组:结果:雷加登罗松组的心肌灌注储备与体重呈反向关系(体重每增加 10 千克平均下降-0.05,95% CI -0.009/-0.0001,P=0.045),但在接受腺苷应激灌注的患者中则没有这种关系(P=0.77)。调整后的逻辑回归分析显示,体重增加 10 千克导致应激反应不足的几率增加 36%(OR= 1.36,95% CI 1.10-1.69,P=0.005)。此外,应激源类型(雷公藤多苷与腺苷)与体重之间存在明显的交互作用(OR=1.09,95% CI 1.02-1.16,P=0.012)。这在倾向匹配亚组中也得到了证实(P=0.024),并且在调整后也没有减弱(P=0.041)。BSA(P=0.006)而非 BMI(P=0.055)与所使用的应激源条件下的反应不足有不同程度的相关性,在对混杂因素进行调整后,这种相关性仍然显著(P=0.025)。体重(>93 千克)或BSA(>2.06 平方米)最高四分位数的患者对雷公藤多苷反应不充分的几率大大增加(体重增加时,OR=8.19,95% CI 2.04-32.97,P=0.003;BSA 增加时,OR=7.75,95% CI 1.93-31.13,P=0.004)。体重和 BSA 对雷公藤多苷反应不足都有很好的判别能力(ROC 曲线下面积分别为 0.84 和 0.83):通过对接受瑞格列酮药物应激的患者进行定量灌注 CMR,我们发现患者体重与临床反应和心肌灌注参数之间存在反比关系。在体重增加的患者中,固定剂量的栓剂方法可能不足以诱导最大充血。对于体重大于 93 千克且 BSA 大于 2.06 平方米的患者,可以考虑使用腺苷等调整体重的压力源。
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引用次数: 0
Free-breathing three-dimensional simultaneous myocardial T1 and T2 mapping based on multi-parametric SAturation-recovery and Variable-flip-Angle. 基于多参数饱和恢复和可变翻转角度(mSAVA)的自由呼吸三维同步心肌 T1 和 T2 图谱。
IF 4.2 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-07-24 DOI: 10.1016/j.jocmr.2024.101065
Dongyue Si, Rui Guo, Lan Cheng, Xiangchuang Kong, Daniel A Herzka, Haiyan Ding

Background: Quantitative myocardial tissue characterization with T1 and T2 parametric mapping can provide an accurate and complete assessment of tissue abnormalities across a broad range of cardiomyopathies. However, current clinical T1 and T2 mapping tools rely predominantly on two-dimensional (2D) breath-hold sequences. Clinical adoption of three-dimensional (3D) techniques is limited by long scan duration. The aim of this study is to develop and validate a time-efficient 3D free-breathing simultaneous T1 and T2 mapping sequence using multi-parametric SAturation-recovery and Variable-flip-Angle (mSAVA).

Methods: mSAVA acquires four volumes for simultaneous whole-heart T1 and T2 mapping. We validated mSAVA using simulations, phantoms, and in-vivo experiments at 3T in 11 healthy subjects and 11 patients with diverse cardiomyopathies. T1 and T2 values by mSAVA were compared with modified Look-Locker inversion recovery (MOLLI) and gradient and spin echo (GraSE), respectively. The clinical performance of mSAVA was evaluated against late gadolinium enhancement (LGE) imaging in patients.

Results: Phantom T1 and T2 by mSAVA showed a strong correlation to reference sequences (R2 = 0.98 and 0.99). In-vivo imaging with an imaging resolution of 1.5 × 1.5 × 8 mm3 could be achieved. Myocardial T1 and T2 of healthy subjects by mSAVA were 1310 ± 46 and 44.6 ± 2.0 ms, respectively, with T1 standard deviation higher than MOLLI (105 ± 12 vs 60 ± 16 ms) and T2 standard deviation lower than GraSE (4.5 ± 0.8 vs 5.5 ± 1.0 ms). mSAVA T1 and T2 maps presented consistent findings in patients undergoing LGE. Myocardial T1 and T2 of all patients by mSAVA were 1421 ± 79 and 47.2 ± 3.3 ms, respectively.

Conclusion: mSAVA is a fast 3D technique promising for clinical whole-heart T1 and T2 mapping.

背景:利用 T1 和 T2 参数图谱对心肌组织进行定量表征,可准确、全面地评估各种心肌病的组织异常。然而,目前的临床 T1 和 T2 映像学工具主要依赖于二维屏气序列。由于扫描时间较长,三维技术的临床应用受到限制。本研究的目的是利用多参数饱和恢复和可变翻转角度(mSAVA),开发并验证一种省时的三维自由呼吸同时 T1 和 T2 绘图序列。我们在 11 名健康受试者和 11 名不同心肌病患者中使用模拟、模型和 3T 体外实验对 mSAVA 进行了验证。mSAVA 的 T1 和 T2 值分别与改良 Look-Locker 反转恢复(MOLLI)和梯度自旋回波(GraSE)进行了比较。还评估了 mSAVA 与患者晚期钆增强(LGE)成像的临床表现:通过 mSAVA 进行的幻影 T1 和 T2 与参考序列显示出很强的相关性(R2=0.98 和 0.99)。体内成像的成像分辨率可达 1.5×1.5×8 mm3。健康受试者的心肌T1和T2分别为1310±46和44.6±2.0ms,T1标准偏差高于MOLLI(105±12 vs. 60±16ms),T2标准偏差低于GraSE(4.5±0.8 vs. 5.5±1.0ms)。结论:mSAVA 是一种快速三维技术,有望用于临床全心 T1 和 T2 地图绘制。
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引用次数: 0
Society for Cardiovascular Magnetic Resonance guidelines for reporting cardiovascular magnetic resonance examinations in patients with congenital heart disease. 心血管磁共振学会《先天性心脏病患者心血管磁共振检查报告指南》。
IF 4.2 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-07-23 DOI: 10.1016/j.jocmr.2024.101062
Lars Grosse-Wortmann, Rachel M Wald, Israel Valverde, Emanuela Valsangiacomo-Buechel, Karen Ordovas, Francesca Raimondi, Lorna Browne, Sonya V Babu-Narayan, Rajesh Krishnamurthy, Deane Yim, Rahul H Rathod
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引用次数: 0
Remote myocardial fibrosis predicts adverse outcome in patients with myocardial infarction on clinical cardiovascular magnetic resonance imaging. 临床心脏磁共振成像显示,远端心肌纤维化可预测心肌梗死患者的不良预后。
IF 4.2 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-07-23 DOI: 10.1016/j.jocmr.2024.101064
Nicholas Black, Joshua Bradley, Erik B Schelbert, Laura J Bonnett, Gavin A Lewis, Jakub Lagan, Christopher Orsborne, Pamela F Brown, Fardad Soltani, Fredrika Fröjdh, Martin Ugander, Timothy C Wong, Miho Fukui, Joao L Cavalcante, Josephine H Naish, Simon G Williams, Theresa McDonagh, Matthias Schmitt, Christopher A Miller

Background: Heart failure (HF) most commonly occurs in patients who have had a myocardial infarction (MI), but factors other than MI size may be deterministic. Fibrosis of myocardium remote from the MI is associated with adverse remodeling. We aimed to 1) investigate the association between remote myocardial fibrosis, measured using cardiovascular magnetic resonance (CMR) extracellular volume fraction (ECV), and HF and death following MI, 2) identify predictors of remote myocardial fibrosis in patients with evidence of MI and determine the relationship with infarct size.

Methods: Multicenter prospective cohort study of 1199 consecutive patients undergoing CMR with evidence of MI on late gadolinium enhancement. Median follow-up was 1133 (895-1442) days. Cox proportional hazards modeling was used to identify factors predictive of the primary outcome, a composite of first hospitalization for HF (HHF) or all-cause mortality, post-CMR. Linear regression modeling was used to identify determinants of remote ECV.

Results: Remote myocardial fibrosis was a strong predictor of primary outcome (χ2: 15.6, hazard ratio [HR]: 1.07 per 1% increase in ECV, 95% confidence interval [CI]: 1.04-1.11, p < 0.001) and was separately predictive of both HHF and death. The strongest predictors of remote ECV were diabetes, sex, natriuretic peptides, and body mass index, but, despite extensive phenotyping, the adjusted model R2 was only 0.283. The relationship between infarct size and remote fibrosis was very weak.

Conclusion: Myocardial fibrosis, measured using CMR ECV, is a strong predictor of HHF and death in patients with evidence of MI. The mechanisms underlying remote myocardial fibrosis formation post-MI remain poorly understood, but factors other than infarct size appear to be important.

背景:心力衰竭(HF)最常见于心肌梗死(MI)患者,但除心肌梗死大小外,其他因素也可能起决定作用。远离心肌梗死的心肌纤维化与不良重塑有关。我们的目的是:i)调查使用心血管磁共振(CMR)测量的远端心肌纤维化细胞外体积(ECV)与心肌梗死后的高房颤和死亡之间的关系;ii)确定有证据表明发生心肌梗死的患者中远端心肌纤维化的预测因素,并确定其与心肌梗死大小的关系:多中心前瞻性队列研究:对 1,199 名连续接受 CMR 检查并有晚期钆增强心肌梗死证据的患者进行研究。中位随访 1,133 (895-1,442) 天。采用 Cox 比例危险模型确定主要结果的预测因素,即 CMR 后首次因 HF(HHF)住院或全因死亡的复合结果。线性回归模型用于确定远端ECV的决定因素:结果:远端心肌纤维化是主要结果的有力预测因素(χ2:15.6,ECV 每增加 1%,HR:1.07,95% CI:1.04-1.11,P2 仅为 0.283)。梗死面积与远端纤维化之间的关系非常微弱:结论:使用 CMR ECV 测量的心肌纤维化是有证据表明发生过心肌梗死的患者出现 HHF 和死亡的有力预测因素。心肌梗死后远端心肌纤维化形成的机制仍不甚明了,但梗死面积以外的其他因素似乎也很重要。
{"title":"Remote myocardial fibrosis predicts adverse outcome in patients with myocardial infarction on clinical cardiovascular magnetic resonance imaging.","authors":"Nicholas Black, Joshua Bradley, Erik B Schelbert, Laura J Bonnett, Gavin A Lewis, Jakub Lagan, Christopher Orsborne, Pamela F Brown, Fardad Soltani, Fredrika Fröjdh, Martin Ugander, Timothy C Wong, Miho Fukui, Joao L Cavalcante, Josephine H Naish, Simon G Williams, Theresa McDonagh, Matthias Schmitt, Christopher A Miller","doi":"10.1016/j.jocmr.2024.101064","DOIUrl":"10.1016/j.jocmr.2024.101064","url":null,"abstract":"<p><strong>Background: </strong>Heart failure (HF) most commonly occurs in patients who have had a myocardial infarction (MI), but factors other than MI size may be deterministic. Fibrosis of myocardium remote from the MI is associated with adverse remodeling. We aimed to 1) investigate the association between remote myocardial fibrosis, measured using cardiovascular magnetic resonance (CMR) extracellular volume fraction (ECV), and HF and death following MI, 2) identify predictors of remote myocardial fibrosis in patients with evidence of MI and determine the relationship with infarct size.</p><p><strong>Methods: </strong>Multicenter prospective cohort study of 1199 consecutive patients undergoing CMR with evidence of MI on late gadolinium enhancement. Median follow-up was 1133 (895-1442) days. Cox proportional hazards modeling was used to identify factors predictive of the primary outcome, a composite of first hospitalization for HF (HHF) or all-cause mortality, post-CMR. Linear regression modeling was used to identify determinants of remote ECV.</p><p><strong>Results: </strong>Remote myocardial fibrosis was a strong predictor of primary outcome (χ<sup>2</sup>: 15.6, hazard ratio [HR]: 1.07 per 1% increase in ECV, 95% confidence interval [CI]: 1.04-1.11, p < 0.001) and was separately predictive of both HHF and death. The strongest predictors of remote ECV were diabetes, sex, natriuretic peptides, and body mass index, but, despite extensive phenotyping, the adjusted model R<sup>2</sup> was only 0.283. The relationship between infarct size and remote fibrosis was very weak.</p><p><strong>Conclusion: </strong>Myocardial fibrosis, measured using CMR ECV, is a strong predictor of HHF and death in patients with evidence of MI. The mechanisms underlying remote myocardial fibrosis formation post-MI remain poorly understood, but factors other than infarct size appear to be important.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11347049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141758954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Can cardiovascular magnetic resonance enhance our understanding of coronary involvement in immunoglobulin subclass 4-related disease? CMR 能否加深我们对 IgG4 相关疾病冠状动脉受累情况的了解?
IF 4.2 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-07-21 DOI: 10.1016/j.jocmr.2024.101063
Tevfik F Ismail
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引用次数: 0
Identifying high-risk Fontan phenotypes using K-means clustering of cardiac magnetic resonance-based dyssynchrony metrics. 利用基于 CMR 的不同步度量的 K-means 聚类识别高风险 Fontan 表型。
IF 4.2 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-07-14 DOI: 10.1016/j.jocmr.2024.101060
Addison Gearhart, Sunakshi Bassi, Rahul H Rathod, Rebecca S Beroukhim, Stuart Lipsitz, Maxwell P Gold, David M Harrild, Audrey Dionne, Sunil J Ghelani

Background: Individuals with a Fontan circulation encompass a heterogeneous group with adverse outcomes linked to ventricular dilation, dysfunction, and dyssynchrony. The purpose of this study was to assess if unsupervised machine learning cluster analysis of cardiovascular magnetic resonance (CMR)-derived dyssynchrony metrics can separate ventricles in the Fontan circulation from normal control left ventricles and identify prognostically distinct subgroups within the Fontan cohort.

Methods: This single-center, retrospective study used 503 CMR studies from Fontan patients (median age 15 y) and 42 from age-matched controls from January 2005 to May 2011. Feature tracking on short-axis cine stacks assessed radial and circumferential strain, strain rate, and displacement. Unsupervised K-means clustering was applied to 24 mechanical dyssynchrony metrics derived from these deformation measurements. Clusters were compared for demographic, anatomical, and composite outcomes of death, or heart transplantation.

Results: Four distinct phenotypic clusters were identified. Over a median follow-up of 4.2 y (interquartile ranges 1.7-8.8 y), 58 (11.5%) patients met the composite outcome. The highest-risk cluster (largely comprised of right or mixed ventricular morphology and dilated, dyssynchronous ventricles) exhibited a higher hazard for the composite outcome compared to the lowest-risk cluster while controlling for ventricular morphology (hazard ratio [HR] 6.4; 95% confidence interval [CI] 2.1-19.3; P value 0.001) and higher indexed end-diastolic volume (HR 3.2; 95% CI 1.04-10.0; P value 0.043) per 10 mL/m2.

Conclusion: Unsupervised machine learning using CMR-derived dyssynchrony metrics identified four distinct clusters of patients with Fontan circulation and healthy controls with varying clinical characteristics and risk profiles. This technique can be used to guide future studies and identify more homogeneous subsets of patients from an overall heterogeneous population.

背景:丰坦循环患者是一个异质性群体,其不良后果与心室扩张、功能障碍和不同步有关。本研究的目的是评估对心脏磁共振(CMR)得出的不同步指标进行无监督机器学习聚类分析是否能将丰坦循环中的心室与正常对照左心室区分开来,并识别丰坦队列中预后不同的亚组:这项单中心回顾性研究使用了2005年1月至2011年5月期间503例Fontan患者(中位年龄15岁)和42例年龄匹配对照组的CMR研究结果。对短轴Cine堆叠图像的特征跟踪评估了径向和环向应变、应变率和位移。根据这些变形测量结果得出的 24 个机械不同步指标进行了无监督 K 均值聚类。对各聚类的人口统计学、解剖学和死亡或心脏移植的综合结果进行了比较:结果:确定了四个不同的表型集群。在4.2年(IQR 1.7-8.8年)的中位随访期间,58名(11.5%)患者达到了综合结果。在控制心室形态(HR 6.4;95% CI 2.1-19.3;P 值 0.001)和每 10 毫升/平方米较高的指数舒张末期容积(HR 3.2;95% CI 1.04-10.0;P 值 0.043)的情况下,与风险最低的群组相比,风险最高的群组(主要由右心室或混合心室形态和扩张、不同步心室组成)显示出更高的综合结果风险:利用CMR衍生的不同步指标进行无监督机器学习,可识别出四个不同的方坦循环患者群和具有不同临床特征和风险特征的健康对照组。这项技术可用于指导未来的研究,并从整体异质性人群中识别出更多同质性患者子集。
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引用次数: 0
Regional variability of cardiovascular magnetic resonance access and utilization in the United States. 美国心血管磁共振成像的获取和利用的地区差异。
IF 4.2 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-07-11 DOI: 10.1016/j.jocmr.2024.101061
Jennifer M Li, David R Ho, Nazia Husain, Robert W Biederman, J Paul Finn, Anthon R Fuisz, Ibrahim M Saeed, Kim-Lien Nguyen

Background: Clinical guidelines and scientific data increasingly support the appropriate use of cardiovascular magnetic resonance (CMR) . The extent of CMR adoption across the United States (US) remains unclear. This observational analysis aims to capture CMR practice patterns in the US.

Methods: Commissioned reports from the Society for Cardiovascular Magnetic Resonance (SCMR), pre-existing survey data from CMR centers, and socioeconomic and coronary heart disease data from the Centers for Disease Control and Prevention were used. The location of imaging centers performing CMR was based on 2018 Medicare claims. Secondary analysis was performed on center-specific survey data from 2017-2019, which were collected by members of the SCMR US Advocacy Subcommittee for quality improvement purposes. The correlation between the number of imaging centers billing for CMR services per million persons, socioeconomic determinants, and coronary heart disease epidemiology was determined.

Results: A total of 591 imaging centers billed the Center for Medicare & Medicaid Services for CMR services in 2018 and 112 (of 155) unique CMR centers responded to the survey. In 2018, CMR services were available in almost all 50 states. Minnesota was the state with the highest number of CMR centers per million Medicare beneficiaries (52.6 centers per million), and Maine had the lowest (4.4 per million). The total density of CMR centers was 16 per million for US Medicare beneficiaries. Sixty-eight percent (83 of 112) of survey responders were cardiologists, and 28% (31/112) were radiologists. In 72% (71/112) of centers, academic health care systems performed 81%-100% of CMR exams. The number of high-volume centers (>500 scans per year) increased by seven between 2017 and 2019. In 2019, 53% (59/112) of centers were considered high-volume centers and had an average of 19 years of experience. Centers performing <50 scans had on average 3.5 years of experience. Approximate patient wait time for a CMR exam was 2 weeks to 1 month.

Conclusion: Despite increasing volume and availability in almost all 50 states, CMR access remains geographically variable. Advocacy efforts to improve access and innovations that reduce imaging time and exam complexity have the potential to increase the adoption of CMR technology.

背景:临床指南和科学数据越来越多地支持适当使用心血管磁共振 (CMR) 成像。美国采用 CMR 的程度仍不清楚。本观察分析旨在了解美国的 CMR 实践模式:方法:使用了心血管磁共振学会(SCMR)的委托报告、CMR 中心已有的调查数据以及美国疾病控制和预防中心的社会经济和冠心病数据。执行CMR的成像中心的位置基于2018年医疗保险报销单。对 2017-2019 年特定中心的调查数据进行了二次分析,这些数据是由 SCMR 美国宣传小组委员会成员为提高质量而收集的。确定了每百万人中开具CMR服务账单的成像中心数量、社会经济决定因素和冠心病流行病学之间的相关性:2018 年,共有 591 家成像中心向医疗保险和医疗补助服务中心(Center for Medicare & Medicaid Services)开具了 CMR 服务账单,112 家(共 155 家)独特的 CMR 中心对调查做出了回应。2018 年,几乎所有 50 个州都提供 CMR 服务。每百万医疗保险受益人中,明尼苏达州的 CMR 中心数量最多(每百万人中有 52.6 个中心),缅因州最少(每百万人中有 4.4 个)。在美国医疗保险受益人中,CMR 中心的总密度为每百万人 16 个。68%(112 位调查对象中的 83 位)的调查对象是心脏病专家,28% 是放射科专家。在 72% 的中心中,学术医疗保健系统进行了 81-100% 的 CMR 检查。2017-2019年间,高容量中心(每年>500次扫描)的数量增加了7个。2019年,53%的中心被认为是高容量中心,平均拥有19年的经验。中心执行结论:尽管几乎所有 50 个州的CMR数量和可用性都在增加,但CMR的可及性仍存在地域差异。通过宣传来提高可及性,并通过创新来缩短成像时间和降低检查复杂性,这些都有可能提高 CMR 技术的采用率。
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引用次数: 0
Diagnostic value of late gadolinium enhancement at cardiovascular magnetic resonance to distinguish arrhythmogenic right ventricular cardiomyopathy from differentials. 心脏磁共振的晚期钆增强对区分心律失常性右室心肌病的诊断价值
IF 4.2 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-07-08 DOI: 10.1016/j.jocmr.2024.101059
Lian Y Rekker, Steven A Muller, Alessio Gasperetti, Mimount Bourfiss, Marish I F J Oerlemans, Maarten J Cramer, Stefan L Zimmerman, Dennis Dooijes, Hanke Schalkx, Pim van der Harst, Cynthia A James, J Peter van Tintelen, Marco Guglielmo, Birgitta K Velthuis, Anneline S J M Te Riele

Background: While late gadolinium enhancement (LGE) is proposed as a diagnostic criterion for arrhythmogenic right ventricular cardiomyopathy (ARVC), the potential of LGE to distinguish ARVC from differentials remains unknown. We aimed to assess the diagnostic value of LGE for ARVC diagnosis.

Methods: We included 132 subjects (60% male, 47 ± 11 years) who had undergone cardiac magnetic resonance imaging with LGE assessment for ARVC or ARVC differentials. ARVC was diagnosed as per 2010 Task Force Criteria (n = 55). ARVC differentials consisted of familial/genetic dilated cardiomyopathy (n = 25), myocarditis (n = 13), sarcoidosis (n = 20), and amyloidosis (n = 19). The diagnosis of all differentials was based on the most current standard of reference. The presence of LGE was evaluated using a 7-segment right ventricle (RV) and 17-segment left ventricle (LV) model. Subsequently, we assessed LGE patterns for every patient individually for fulfilling LV- and/or RV-LGE per Padua criteria, independent of their clinical diagnosis (i.e. phenotype). Diagnostic values were analyzed using sensitivity and specificity for any RV-LGE, any LV-LGE, RV-LGE per Padua criteria, and prevalence graphs for LV-LGE per Padua criteria. The optimal integration of LGE for ARVC diagnosis was determined using classification and regression tree analysis.

Results: One-third (38%) of ARVC patients had RV-LGE, while half (51%) had LV-LGE. RV-LGE was less frequently observed in ARVC vs non-ARVC patients (38% vs 58%, p = 0.034) leading to a poor discriminatory potential (any RV-LGE: sensitivity 38%, specificity 42%; RV-LGE per Padua criteria: sensitivity 36%, specificity 44%). Compared to ARVC patients, non-ARVC patients more often had LV-LGE (91% vs 51%, p < 0.001) which was also more globally distributed (median 9 [interquartile range (IQR): 3-13] vs 0 [IQR: 0-3] segments, p < 0.001). The absence of anteroseptal and absence of extensive (≥5 segments) mid-myocardial LV-LGE, and absence of moderate (≥2 segments) mid-myocardial LV-LGE predicted ARVC with good diagnostic performance (sensitivity 93%, specificity 78%).

Conclusion: LGE is often present in ARVC differentials and may lead to false positive diagnoses when used without knowledge of LGE patterns. Moderate RV-LGE without anteroseptal and mid-myocardial LV-LGE is typically observed in ARVC.

背景:虽然晚期钆增强(LGE)被建议作为心律失常性右室心肌病(ARVC)的诊断标准,但 LGE 区分 ARVC 和鉴别诊断的潜力仍然未知。我们旨在评估 LGE 对 ARVC 诊断的诊断价值:我们纳入了 132 名接受过心脏磁共振成像和 LGE 评估的 ARVC 或 ARVC 差异型受试者(男性占 60%,47±11 岁)。ARVC根据2010年工作组标准诊断(55人)。ARVC 差异包括家族性/遗传性扩张型心肌病(25 人)、心肌炎(13 人)、肉样瘤病(20 人)和淀粉样变性(19 人)。所有鉴别诊断均基于最新的黄金标准。使用 7 段左心室模型和 17 段左心室模型评估是否存在 LGE。随后,我们根据帕多瓦标准评估了每位患者的 LGE 模式,以确定其是否符合 LV 和/或 RV-LGE,而与临床诊断(即表型)无关。我们使用敏感性和特异性分析了任何 RV-LGE、任何 LV-LGE、符合帕多瓦标准的 RV-LGE 的诊断价值,以及符合帕多瓦标准的 LV-LGE 的患病率图。结果:三分之一(38%)的 ARVC 患者患有 RV-LGE,而一半(51%)的患者患有 LV-LGE。与非 ARVC 患者相比,RV-LGE 在 ARVC 患者中的观察频率较低(38% 对 58%,P=0.034),因此鉴别潜力较差(任何 RV-LGE:灵敏度为 38%,特异性为 42%;根据帕多瓦标准观察的 RV-LGE:灵敏度为 36%,特异性为 44%)。与 ARVC 患者相比,非 ARVC 患者更常出现 LV-LGE (91% 对 51%,P 结论:LGE 常出现在 ARVC 鉴别中,在不了解 LGE 模式的情况下使用可能会导致假阳性诊断。在 ARVC 中通常可观察到中度 RV-LGE 而无前室壁和心肌中段 LV-LGE。
{"title":"Diagnostic value of late gadolinium enhancement at cardiovascular magnetic resonance to distinguish arrhythmogenic right ventricular cardiomyopathy from differentials.","authors":"Lian Y Rekker, Steven A Muller, Alessio Gasperetti, Mimount Bourfiss, Marish I F J Oerlemans, Maarten J Cramer, Stefan L Zimmerman, Dennis Dooijes, Hanke Schalkx, Pim van der Harst, Cynthia A James, J Peter van Tintelen, Marco Guglielmo, Birgitta K Velthuis, Anneline S J M Te Riele","doi":"10.1016/j.jocmr.2024.101059","DOIUrl":"10.1016/j.jocmr.2024.101059","url":null,"abstract":"<p><strong>Background: </strong>While late gadolinium enhancement (LGE) is proposed as a diagnostic criterion for arrhythmogenic right ventricular cardiomyopathy (ARVC), the potential of LGE to distinguish ARVC from differentials remains unknown. We aimed to assess the diagnostic value of LGE for ARVC diagnosis.</p><p><strong>Methods: </strong>We included 132 subjects (60% male, 47 ± 11 years) who had undergone cardiac magnetic resonance imaging with LGE assessment for ARVC or ARVC differentials. ARVC was diagnosed as per 2010 Task Force Criteria (n = 55). ARVC differentials consisted of familial/genetic dilated cardiomyopathy (n = 25), myocarditis (n = 13), sarcoidosis (n = 20), and amyloidosis (n = 19). The diagnosis of all differentials was based on the most current standard of reference. The presence of LGE was evaluated using a 7-segment right ventricle (RV) and 17-segment left ventricle (LV) model. Subsequently, we assessed LGE patterns for every patient individually for fulfilling LV- and/or RV-LGE per Padua criteria, independent of their clinical diagnosis (i.e. phenotype). Diagnostic values were analyzed using sensitivity and specificity for any RV-LGE, any LV-LGE, RV-LGE per Padua criteria, and prevalence graphs for LV-LGE per Padua criteria. The optimal integration of LGE for ARVC diagnosis was determined using classification and regression tree analysis.</p><p><strong>Results: </strong>One-third (38%) of ARVC patients had RV-LGE, while half (51%) had LV-LGE. RV-LGE was less frequently observed in ARVC vs non-ARVC patients (38% vs 58%, p = 0.034) leading to a poor discriminatory potential (any RV-LGE: sensitivity 38%, specificity 42%; RV-LGE per Padua criteria: sensitivity 36%, specificity 44%). Compared to ARVC patients, non-ARVC patients more often had LV-LGE (91% vs 51%, p < 0.001) which was also more globally distributed (median 9 [interquartile range (IQR): 3-13] vs 0 [IQR: 0-3] segments, p < 0.001). The absence of anteroseptal and absence of extensive (≥5 segments) mid-myocardial LV-LGE, and absence of moderate (≥2 segments) mid-myocardial LV-LGE predicted ARVC with good diagnostic performance (sensitivity 93%, specificity 78%).</p><p><strong>Conclusion: </strong>LGE is often present in ARVC differentials and may lead to false positive diagnoses when used without knowledge of LGE patterns. Moderate RV-LGE without anteroseptal and mid-myocardial LV-LGE is typically observed in ARVC.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11327940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141579782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Society for Cardiovascular Magnetic Resonance Registry at 150,000. 心血管磁共振学会注册人数为 15 万。
IF 4.2 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-07-04 DOI: 10.1016/j.jocmr.2024.101055
Matthew S Tong, Jeremy A Slivnick, Behzad Sharif, Han W Kim, Alistair A Young, Lilia M Sierra-Galan, Kanae Mukai, Afshin Farzaneh-Far, Sadeer Al-Kindi, Angel T Chan, George Dibu, Michael D Elliott, Vanessa M Ferreira, John Grizzard, Sebastian Kelle, Simon Lee, Maan Malahfji, Steffen E Petersen, Venkateshwar Polsani, Olga H Toro-Salazar, Kamran A Shaikh, Chetan Shenoy, Monvadi B Srichai, Jadranka Stojanovska, Qian Tao, Janet Wei, Jonathan W Weinsaft, W Benjamin Wince, Priya D Chudgar, Matthew Judd, Robert M Judd, Dipan J Shah, Orlando P Simonetti

Background: Cardiovascular magnetic resonance (CMR) is increasingly utilized to evaluate expanding cardiovascular conditions. The Society for Cardiovascular Magnetic Resonance (SCMR) Registry is a central repository for real-world clinical data to support cardiovascular research, including those relating to outcomes, quality improvement, and machine learning. The SCMR Registry is built on a regulatory-compliant, cloud-based infrastructure that houses searchable content and Digital Imaging and Communications in Medicine images. The goal of this study is to summarize the status of the SCMR Registry at 150,000 exams.

Methods: The processes for data security, data submission, and research access are outlined. We interrogated the Registry and presented a summary of its contents.

Results: Data were compiled from 154,458 CMR scans across 20 United States sites, containing 299,622,066 total images (∼100 terabytes of storage). Across reported values, the human subjects had an average age of 58 years (range 1 month to >90 years old), were 44% (63,070/145,275) female, 72% (69,766/98,008) Caucasian, and had a mortality rate of 8% (9,962/132,979). The most common indication was cardiomyopathy (35,369/131,581, 27%), and most frequently used current procedural terminology code was 75561 (57,195/162,901, 35%). Macrocyclic gadolinium-based contrast agents represented 89% (83,089/93,884) of contrast utilization after 2015. Short-axis cines were performed in 99% (76,859/77,871) of tagged scans, short-axis late gadolinium enhancement (LGE) in 66% (51,591/77,871), and stress perfusion sequences in 30% (23,241/77,871). Mortality data demonstrated increased mortality in patients with left ventricular ejection fraction <35%, the presence of wall motion abnormalities, stress perfusion defects, and infarct LGE, compared to those without these markers. There were 456,678 patient-years of all-cause mortality follow-up, with a median follow-up time of 3.6 years.

Conclusion: The vision of the SCMR Registry is to promote evidence-based utilization of CMR through a collaborative effort by providing a web mechanism for centers to securely upload de-identified data and images for research, education, and quality control. The Registry quantifies changing practice over time and supports large-scale real-world multicenter observational studies of prognostic utility.

摘要背景:心血管磁共振(CMR)越来越多地被用于评估不断扩大的心血管疾病:背景:心血管磁共振(CMR)越来越多地被用于评估不断扩大的心血管疾病。SCMR 注册中心是真实世界临床数据的中央存储库,用于支持心血管研究,包括与结果、质量改进和机器学习相关的研究。SCMR 注册中心建立在一个符合法规要求、基于云的基础架构上,其中包含可搜索内容和医学数字成像和通信(DICOM)图像:方法:概述了数据安全、数据提交和研究访问的流程。方法:概述了数据安全、数据提交和研究访问的流程。我们对注册中心进行了询问,并对其内容进行了总结:数据来自美国 20 个站点的 154,458 次 CMR 扫描,共包含 299,622,066 张图像(约 100 TB 的存储空间)。受试者的平均年龄为 58 岁(从 1 个月到超过 90 岁不等),44% 为女性,72% 为白种人,死亡率为 8%。最常见的适应症是心肌病(27%),最常用的现行程序术语(CPT)代码是 75561(35%)。2015年后,大环钆类造影剂占造影剂使用量的89%。99%的扫描使用了短轴Cines,66%的扫描使用了短轴LGE,30%的扫描使用了应激灌注序列。死亡率数据显示,左室射血分数(LVEF)小于35%、存在室壁运动异常、应激灌注缺陷和梗死晚期钆增强(LGE)的患者死亡率高于无这些标记物的患者。对456,678名患者进行了全因死亡率随访,中位随访时间为3.6年:SCMR 注册中心的愿景是通过合作努力,为各中心提供一个网络机制,安全上传用于研究、教育和质量控制的去标识化数据和图像,从而促进以证据为基础的 CMR 利用。该注册中心可量化随时间推移而不断变化的实践,并支持对预后效用进行大规模真实世界多中心观察研究。精简摘要:SCMR 注册中心是一个符合法规要求的中央云端存储库,用于多中心心血管研究的真实世界临床数据和 DICOM 图像,包括基于结果的数据。注册中心包含 299,622,066 张 DICOM 图像和 456,678 个患者随访年。来自美国 20 个站点的 154,458 次 CMR 扫描的数据显示,心肌病是最常见的适应症,2015 年后大环内酯钆对比剂的使用率达到 89%。总死亡率为 8%,其中 LVEF 较高的患者死亡率较高。
{"title":"The Society for Cardiovascular Magnetic Resonance Registry at 150,000.","authors":"Matthew S Tong, Jeremy A Slivnick, Behzad Sharif, Han W Kim, Alistair A Young, Lilia M Sierra-Galan, Kanae Mukai, Afshin Farzaneh-Far, Sadeer Al-Kindi, Angel T Chan, George Dibu, Michael D Elliott, Vanessa M Ferreira, John Grizzard, Sebastian Kelle, Simon Lee, Maan Malahfji, Steffen E Petersen, Venkateshwar Polsani, Olga H Toro-Salazar, Kamran A Shaikh, Chetan Shenoy, Monvadi B Srichai, Jadranka Stojanovska, Qian Tao, Janet Wei, Jonathan W Weinsaft, W Benjamin Wince, Priya D Chudgar, Matthew Judd, Robert M Judd, Dipan J Shah, Orlando P Simonetti","doi":"10.1016/j.jocmr.2024.101055","DOIUrl":"10.1016/j.jocmr.2024.101055","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular magnetic resonance (CMR) is increasingly utilized to evaluate expanding cardiovascular conditions. The Society for Cardiovascular Magnetic Resonance (SCMR) Registry is a central repository for real-world clinical data to support cardiovascular research, including those relating to outcomes, quality improvement, and machine learning. The SCMR Registry is built on a regulatory-compliant, cloud-based infrastructure that houses searchable content and Digital Imaging and Communications in Medicine images. The goal of this study is to summarize the status of the SCMR Registry at 150,000 exams.</p><p><strong>Methods: </strong>The processes for data security, data submission, and research access are outlined. We interrogated the Registry and presented a summary of its contents.</p><p><strong>Results: </strong>Data were compiled from 154,458 CMR scans across 20 United States sites, containing 299,622,066 total images (∼100 terabytes of storage). Across reported values, the human subjects had an average age of 58 years (range 1 month to >90 years old), were 44% (63,070/145,275) female, 72% (69,766/98,008) Caucasian, and had a mortality rate of 8% (9,962/132,979). The most common indication was cardiomyopathy (35,369/131,581, 27%), and most frequently used current procedural terminology code was 75561 (57,195/162,901, 35%). Macrocyclic gadolinium-based contrast agents represented 89% (83,089/93,884) of contrast utilization after 2015. Short-axis cines were performed in 99% (76,859/77,871) of tagged scans, short-axis late gadolinium enhancement (LGE) in 66% (51,591/77,871), and stress perfusion sequences in 30% (23,241/77,871). Mortality data demonstrated increased mortality in patients with left ventricular ejection fraction <35%, the presence of wall motion abnormalities, stress perfusion defects, and infarct LGE, compared to those without these markers. There were 456,678 patient-years of all-cause mortality follow-up, with a median follow-up time of 3.6 years.</p><p><strong>Conclusion: </strong>The vision of the SCMR Registry is to promote evidence-based utilization of CMR through a collaborative effort by providing a web mechanism for centers to securely upload de-identified data and images for research, education, and quality control. The Registry quantifies changing practice over time and supports large-scale real-world multicenter observational studies of prognostic utility.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11314894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141544875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Journal of Cardiovascular Magnetic Resonance
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