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Parents' Experiences of Raising 7- to 11-Year-Old Children With ADHD and Perception of a Proposed Parenting Program: A Qualitative Study. 父母养育7- 11岁ADHD儿童的经验及对建议育儿计划的看法:一项定性研究。
IF 2.7 3区 医学 Q2 PSYCHIATRY Pub Date : 2025-01-06 DOI: 10.1177/10870547241309526
Louise E Brown, Mary Tallon, Garth Kendall, Mark Boyes, Bronwyn Myers

Objective: To examine the experiences of Australian parents raising primary school-aged children with ADHD and gather feedback on a proposed ADHD parenting program.

Methods: Reflexive thematic analysis of semi-structured interviews undertaken with 11 Australian parents of 7- to 11-year-old children with ADHD. Interviews were conducted over Webex, audio recorded, transcribed verbatim, and analyzed in NVivo Ltd. software.

Results: We identified four themes: (1) "I love my child but their ADHD traits are challenging," (2) "Compliance, control, and completion," (3) "It's hard, burdensome, and exhausting and I can feel like I'm alone," and (4) "What a welcome relief."

Conclusion: Parents report that although raising neurotypical children is difficult, the presence of childhood ADHD increases the emotional and support burden placed on them. Parents were also very interested in and supportive of the proposed ADHD parenting program. The program aims to enhance parents' understanding of the neurocognitive implications of ADHD and to foster secure parent-child attachment, attuned parental responsiveness, and age-appropriate development of traits that promote well-being, adaption and recovery in people with ADHD.).

目的:研究澳大利亚父母养育患有ADHD的小学学龄儿童的经验,并收集对ADHD育儿计划的反馈意见。方法:对11名7- 11岁ADHD儿童的澳大利亚父母进行半结构化访谈,并对访谈内容进行反身性主题分析。访谈是通过Webex进行的,录音,逐字转录,并在NVivo有限公司的软件中进行分析。结果:我们确定了四个主题:(1)“我爱我的孩子,但他们的多动症特征很有挑战性。”“遵从性、控制和完成”(3)“这很辛苦,负担很重,很累,我觉得我很孤单。”“真是可喜的解脱。”结论:父母报告说,虽然抚养神经型儿童很困难,但儿童多动症的存在增加了他们的情感和支持负担。家长们也非常感兴趣并支持ADHD育儿计划。该项目旨在提高家长对多动症神经认知影响的理解,培养安全的亲子依恋,协调父母的反应,以及促进多动症患者健康、适应和康复的年龄相适应的特征发展。
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引用次数: 0
Could Maladaptive Daydreaming Delay ADHD Diagnosis Until Adulthood? Clinical Characteristics of Adults With ADHD Based on Diagnosis Age. 不适应白日梦会将ADHD的诊断推迟到成年吗?基于诊断年龄的成人ADHD临床特征分析。
IF 2.7 3区 医学 Q2 PSYCHIATRY Pub Date : 2025-01-06 DOI: 10.1177/10870547241310990
Ali Kandeğer, Hasan Ali Güler, Münise Seda Özaltın, Ömer Bayırlı, Hacer Söylemez, Elif Yıldız, Bengi Semerci

Introduction: Our study aimed to compare the sociodemographic, diagnostic, clinical, and self-report scale data of adults diagnosed with ADHD in childhood/adolescence versus adulthood and to identify risk factors associated with delayed/missed diagnosis for ADHD.

Method: Sociodemographic, clinical, and diagnostic data of 214 adults with ADHD, followed at the Adult Neurodevelopmental Disorders Clinic, Selçuk University, between January 2022 and January 2024, were analyzed. The diagnostic evaluations were made using the Structured Clinical Interview for DSM-5 Clinician Version. Clinical data included age, gender, years of education, alcohol/substance use, diagnosis age, and current medication use for ADHD. Data collected from self-report scales included both ADHD-related measurements and comorbidity-related measurements.

Results: The findings revealed that only 34.4% (n = 74) of sample received a formal ADHD diagnosis during childhood/adolescence. Adults diagnosed with ADHD in adulthood were older and had higher education levels, more severe ADHD symptoms, and increased maladaptive daydreaming (MD) scores, compared to those diagnosed in childhood or adolescence. Logistic regression analysis indicated that the severity of MD was associated with being in the group diagnosed with ADHD in adulthood while controlling for other significant parameters from bivariate analyses, such as age, years of education, and current medication use for ADHD. Finally, analyses conducted separately in both groups showed that: (1) increased MD severity was a predictor of higher ADHD symptoms in those diagnosed in adulthood, but not in those diagnosed in childhood/adolescence, and (2) MD severity had a stronger correlation with ADHD symptoms, the number of comorbid psychiatric disorders, and symptoms of excessive mind wandering, depression, and anxiety in those diagnosed in adulthood compared to those diagnosed in childhood/adolescence.

Conclusion: MD may delay ADHD diagnosis until adulthood by masking and compensating ADHD symptoms and delay in referral to mental health professionals, and it might also be a predictive symptom for recognizing ADHD in adults who have never been diagnosed; however, longitudinal studies are needed to confirm this.

本研究旨在比较儿童期/青春期与成年期诊断为ADHD的成年人的社会人口学、诊断、临床和自我报告量表数据,并确定与ADHD延迟/漏诊相关的危险因素。方法:分析2022年1月至2024年1月期间在塞尔帕鲁克大学成人神经发育障碍诊所随访的214名ADHD成人的社会人口学、临床和诊断数据。诊断评估采用DSM-5临床医生版结构化临床访谈进行。临床数据包括年龄、性别、受教育年限、酒精/物质使用、诊断年龄和当前ADHD药物使用情况。从自我报告量表收集的数据包括adhd相关测量和合并症相关测量。结果:调查结果显示,只有34.4% (n = 74)的样本在儿童/青少年时期接受过正式的ADHD诊断。与儿童期或青春期诊断出ADHD的人相比,成年期诊断出ADHD的成年人年龄更大,受教育程度更高,ADHD症状更严重,不适应白日梦(MD)得分更高。Logistic回归分析表明,在控制双变量分析的其他重要参数(如年龄、受教育年限和目前治疗ADHD的药物使用情况)的同时,MD的严重程度与成年后诊断为ADHD的组相关。最后,两组分别进行的分析显示:(1)成年期诊断的MD严重程度升高是ADHD症状升高的预测因子,而儿童期/青春期诊断的MD严重程度升高则不是;(2)与儿童期/青春期诊断的患者相比,成年期诊断的MD严重程度与ADHD症状、共病精神疾病的数量、过度神游、抑郁和焦虑症状有更强的相关性。结论:ADHD可能通过掩盖和补偿ADHD症状以及延迟转诊到精神卫生专业人员而延迟ADHD的诊断,并且它也可能是未确诊的成年人识别ADHD的预测症状;然而,需要纵向研究来证实这一点。
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引用次数: 0
Operationalizing In-session Treatment Engagement Strategies and Behaviors for Adolescents With ADHD and Their Parents. ADHD青少年及其父母的治疗参与策略和行为的实施。
IF 2.7 3区 医学 Q2 PSYCHIATRY Pub Date : 2025-01-05 DOI: 10.1177/10870547241308632
Margaret H Sibley, Lourdes M Rodriguez, Melissa Lopez, Erika M Brochu, Fabiana V Bracho, Mercedes Ortiz, Jasmine Hashimoto

Objective: Many treatment engagement challenges are documented for adolescents with ADHD. Across contexts, helping professionals (i.e., therapists, prescribers, educators, coaches) might benefit from an engagement strategy toolbox to facilitate work with adolescents with ADHD and their families.

Method: The current study describes the development and psychometric testing of the ADHD Engagement Process Code (AEPC), a measure that operationalizes engagement strategies in the context of a blended behavioral/motivational interviewing treatment for adolescent ADHD (Supporting Teens' Autonomy Daily; STAND). The AEPC also operationalizes in-session parent and adolescent engagement-related behaviors. Behavior counts and global codes were coded for 840 audio-recorded STAND sessions delivered by 21 therapists to 121 adolescents. Subsets of tapes were double coded using the AEPC's parent, adolescent, and therapist coding systems to assess kappa for line-by-line verbalizations and intraclass correlations for session-level behavior counts and global scores. Construct validity was assessed. We explored low frequency and low variability codes and examined correlations between codes.

Results: AEPC codes possessed good to excellent inter-rater reliability and strong discriminant validity. Three low frequency codes and one low variability global were identified indicating opportunities for AEPC refinement.

Conclusions: The AEPC is publicly available (https://osf.io/kshfy/) and offers a library of adolescent-specific codes for those interested in measuring provider, parent, or adolescent engagement behaviors in relevant populations or contexts.

目的:许多治疗参与挑战记录了青少年多动症。在不同的情况下,帮助专业人士(即治疗师、处方医生、教育工作者、教练)可能会从参与策略工具箱中受益,以促进与患有多动症的青少年及其家庭的合作。方法:本研究描述了ADHD参与过程代码(AEPC)的开发和心理测量测试,AEPC是一种在青少年ADHD混合行为/动机访谈治疗背景下实施参与策略的措施(《支持青少年自主日报》;站)。AEPC还对会话中父母和青少年参与相关行为进行操作。行为计数和全球代码被编码为840个音频记录的STAND会话,由21名治疗师向121名青少年提供。使用AEPC的家长、青少年和治疗师编码系统对磁带子集进行双重编码,以评估逐行语言表达的kappa和会话级行为计数和整体得分的班级内相关性。评估构念效度。我们探索了低频率和低可变性代码,并检查了代码之间的相关性。结果:AEPC码具有良好至优异的量表间信度和较强的判别效度。确定了三个低频编码和一个低变率全局,表明有机会改进AEPC。结论:AEPC是公开的(https://osf.io/kshfy/),并为那些有兴趣在相关人群或环境中测量提供者、父母或青少年参与行为的人提供了一个青少年特定代码库。
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引用次数: 0
Echocardiographic Evaluation of the Effect of Long-Term Methylphenidate Use on Cardiovascular Functions. 超声心动图评价长期使用哌甲酯对心血管功能的影响。
IF 2.7 3区 医学 Q2 PSYCHIATRY Pub Date : 2025-01-04 DOI: 10.1177/10870547241307680
Çağatay Tunca, İbrahim Hakan Güllü, Saadet Demirtaş İnci, Kamuran Kalkan, Ruken Demirkol Tunca, Ayşegül Efe, Ayşe Nur Özkaya Ibiş, Alperen Taş, Mehmet Taha Özkan, Veysel Ozan Tanik, Orçun Ortaköylü, Nail Burak Özbeyaz

Objective: ADHD is one of the most common neurodevelopmental disorders, seen in children and adolescents, and is often treated with various pharmacological agents, especially methylphenidate. There are differing opinions in the literature regarding the cardiovascular safety of long-term methylphenidate use. Studies suggest that the drug may increase the risk of hypertension, myocardial infarction, ventricular arrhythmia, sudden cardiac death, cardiomyopathy, heart failure (HF), pulmonary hypertension, and stroke. This study aimed to compare the clinical and echocardiographic characteristics of patients diagnosed with ADHD who have been using long-acting methylphenidate for an extended period with age-gender matched healthy volunteers.

Materials and methods: A total of 70 patients diagnosed with ADHD, who had been using long-acting methylphenidate for 2 years or more, and 51 healthy volunteers, who were referred to our clinic, were included in our study. Patients were evaluated with basic and advanced techniques such as Motion Mode (M-mode), two-dimensional (2D), Doppler, and 2D-Speckle Tracking (STE) using transthoracic echocardiography. All other data were evaluated instantly after the processing with the strain images analysis program.

Results: Statistically significant differences were observed between the case and control groups in terms of body mass index (BMI) and systolic blood pressure (SBP), with BMI negatively correlated and SBP positively correlated with methylphenidate use duration. There was no significant difference between the groups in apical four-chamber, three-chamber, two-chamber, and global longitudinal strain (GLS) values obtained by 2D-STE technique indicating early deterioration. The Left Ventricular (LV) lateral E' value, which indicates diastolic dysfunction, was lower in the drug group, but still within normal limits. The lateral LV E', Right Ventricular (RV) E', and RV A' values showed a significant negative correlation with the duration of drug use and remained within normal limits. Other parameters evaluating systolic/diastolic function such as E/E', left ventricular ejection fraction (LVEF), myocardial performance index (MPI), and tricuspid/mitral annular plane systolic excursion (TAPSE/MAPSE) did not differ significantly between the groups and were within normal limits. Valve structures and regurgitations were also not significantly different between the two groups.

Conclusion: Considering all parameters, we conclude that long-term use of long-acting methylphenidate does not cause cardiovascular dysfunction in late adolescent and early adult individuals. The observed differences in the E' lateral value between the case and control groups, as well as the slight correlation of lateral LV E', RV E', and RV A' values with the duration of use, do not directly indicate cardiac dysfunction.

目的:ADHD是儿童和青少年中最常见的神经发育障碍之一,经常使用各种药物治疗,尤其是哌醋甲酯。关于长期使用哌甲酯的心血管安全性,文献中有不同的观点。研究表明,该药可能增加高血压、心肌梗死、室性心律失常、心源性猝死、心肌病、心力衰竭(HF)、肺动脉高压和中风的风险。本研究旨在比较长期使用长效哌醋甲酯的ADHD患者与年龄性别匹配的健康志愿者的临床和超声心动图特征。材料与方法:本研究共纳入70例经诊断为ADHD且使用长效哌醋甲酯2年以上的患者,以及51例转诊至本诊所的健康志愿者。使用经胸超声心动图对患者进行基本和高级技术评估,如运动模式(M-mode)、二维(2D)、多普勒和二维斑点追踪(STE)。所有其他数据在应变图像分析程序处理后立即进行评估。结果:病例组体重指数(BMI)、收缩压(SBP)与对照组比较差异有统计学意义,BMI与哌甲酯使用时间呈负相关,收缩压与哌甲酯使用时间呈正相关。通过2D-STE技术获得的顶端四室、三室、两室和全局纵向应变(GLS)值显示早期恶化,组间无显著差异。显示舒张功能不全的左室(LV)侧侧E′值在药物组较低,但仍在正常范围内。左室E′、右室E′、右室A′与用药时间呈显著负相关,均在正常范围内。其他评估收缩/舒张功能的参数,如E/E′、左心室射血分数(LVEF)、心肌性能指数(MPI)和三尖瓣/二尖瓣环面收缩漂移(TAPSE/MAPSE)在组间无显著差异,均在正常范围内。两组之间的瓣膜结构和反流也无显著差异。结论:综合考虑所有参数,我们得出结论,长期使用长效哌醋甲酯不会导致青春期晚期和成年早期个体的心血管功能障碍。观察到病例组与对照组E′侧位值的差异,以及左室E′、左室E′、左室A′侧位值与用药时间的轻微相关性,不能直接提示心功能不全。
{"title":"Echocardiographic Evaluation of the Effect of Long-Term Methylphenidate Use on Cardiovascular Functions.","authors":"Çağatay Tunca, İbrahim Hakan Güllü, Saadet Demirtaş İnci, Kamuran Kalkan, Ruken Demirkol Tunca, Ayşegül Efe, Ayşe Nur Özkaya Ibiş, Alperen Taş, Mehmet Taha Özkan, Veysel Ozan Tanik, Orçun Ortaköylü, Nail Burak Özbeyaz","doi":"10.1177/10870547241307680","DOIUrl":"https://doi.org/10.1177/10870547241307680","url":null,"abstract":"<p><strong>Objective: </strong>ADHD is one of the most common neurodevelopmental disorders, seen in children and adolescents, and is often treated with various pharmacological agents, especially methylphenidate. There are differing opinions in the literature regarding the cardiovascular safety of long-term methylphenidate use. Studies suggest that the drug may increase the risk of hypertension, myocardial infarction, ventricular arrhythmia, sudden cardiac death, cardiomyopathy, heart failure (HF), pulmonary hypertension, and stroke. This study aimed to compare the clinical and echocardiographic characteristics of patients diagnosed with ADHD who have been using long-acting methylphenidate for an extended period with age-gender matched healthy volunteers.</p><p><strong>Materials and methods: </strong>A total of 70 patients diagnosed with ADHD, who had been using long-acting methylphenidate for 2 years or more, and 51 healthy volunteers, who were referred to our clinic, were included in our study. Patients were evaluated with basic and advanced techniques such as Motion Mode (M-mode), two-dimensional (2D), Doppler, and 2D-Speckle Tracking (STE) using transthoracic echocardiography. All other data were evaluated instantly after the processing with the strain images analysis program.</p><p><strong>Results: </strong>Statistically significant differences were observed between the case and control groups in terms of body mass index (BMI) and systolic blood pressure (SBP), with BMI negatively correlated and SBP positively correlated with methylphenidate use duration. There was no significant difference between the groups in apical four-chamber, three-chamber, two-chamber, and global longitudinal strain (GLS) values obtained by 2D-STE technique indicating early deterioration. The Left Ventricular (LV) lateral E' value, which indicates diastolic dysfunction, was lower in the drug group, but still within normal limits. The lateral LV E', Right Ventricular (RV) E', and RV A' values showed a significant negative correlation with the duration of drug use and remained within normal limits. Other parameters evaluating systolic/diastolic function such as E/E', left ventricular ejection fraction (LVEF), myocardial performance index (MPI), and tricuspid/mitral annular plane systolic excursion (TAPSE/MAPSE) did not differ significantly between the groups and were within normal limits. Valve structures and regurgitations were also not significantly different between the two groups.</p><p><strong>Conclusion: </strong>Considering all parameters, we conclude that long-term use of long-acting methylphenidate does not cause cardiovascular dysfunction in late adolescent and early adult individuals. The observed differences in the E' lateral value between the case and control groups, as well as the slight correlation of lateral LV E', RV E', and RV A' values with the duration of use, do not directly indicate cardiac dysfunction.</p>","PeriodicalId":15237,"journal":{"name":"Journal of Attention Disorders","volume":" ","pages":"10870547241307680"},"PeriodicalIF":2.7,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Black Mothers of Children With and Without ADHD: Relationships Among Maternal Psychopathology, Parenting Stress, and Parenting Cognitions. 有多动症和无多动症儿童的黑人母亲:母亲心理病理学、养育压力和养育认知之间的关系。
IF 2.7 3区 医学 Q2 PSYCHIATRY Pub Date : 2025-01-01 Epub Date: 2024-10-06 DOI: 10.1177/10870547241288344
Heather A Jones, Stephanie A Wilson, Amanda M Parks, Alfonso L Floyd, Annie E Rabinovitch, Chantelle C Miller

Introduction: Parents of children with attention-deficit/hyperactivity disorder (ADHD) endorse increased parenting stress and lower levels of parenting efficacy and satisfaction as compared to parents of children without ADHD. Additionally, maternal ADHD and depression differentiate children with and without ADHD, with children with ADHD being more likely to have a mother with psychopathology.

Method: With a focus on an understudied population, we investigated the extent to which maternal self-reported ADHD and depression were associated with self-reported parenting stress and parenting cognitions in 70 Black mothers of children with (maternal Mage = 35.52, SD = 6.49) and without ADHD (maternal Mage = 35.39, SD = 6.53) recruited from a metropolitan area in the southeastern United States.

Results: Analyses indicated that Black mothers of children with ADHD reported higher levels of parenting stress, lower levels of parenting efficacy, and lower levels of parenting satisfaction. However, there were no significant differences between groups on measures of maternal ADHD or depression. Maternal depression significantly accounted for variability in both parenting satisfaction and parenting stress beyond child ADHD and maternal education. With maternal depression in the models, the association between maternal ADHD and parenting stress and parenting satisfaction lost significance.

Discussion: Given the racial disparities in the treatment of ADHD, future research should focus on investigating the linkages between maternal depression, parenting stress, parenting satisfaction, and parenting behaviors in Black mothers in order to delineate whether there are cultural adaptations that may improve treatment utilization rates for child ADHD within this population.

导言:与没有注意力缺陷/多动症(ADHD)的儿童的父母相比,有注意力缺陷/多动症(ADHD)的儿童的父母在养育子女方面所承受的压力更大,养育子女的效率和满意度也更低。此外,母亲患有多动症和抑郁症也会对多动症儿童和非多动症儿童产生影响,多动症儿童的母亲更有可能患有精神疾病:方法:我们以研究不足的人群为重点,调查了从美国东南部大都会地区招募的 70 位有多动症儿童(母亲 Mage = 35.52,SD = 6.49)和无多动症儿童(母亲 Mage = 35.39,SD = 6.53)的黑人母亲中,母亲自我报告的多动症和抑郁症与自我报告的养育压力和养育认知的关联程度:分析表明,多动症儿童的黑人母亲在养育子女方面的压力较大,养育子女的效率较低,养育子女的满意度较低。然而,在母亲多动症或抑郁症的测量方面,各组之间没有明显差异。除了儿童多动症和母亲教育程度之外,母亲抑郁在很大程度上影响了养育满意度和养育压力的变化。在母亲抑郁的模型中,母亲多动症与养育压力和养育满意度之间的关系失去了显著性:讨论:鉴于多动症治疗中的种族差异,未来的研究应侧重于调查黑人母亲的母亲抑郁、养育压力、养育满意度和养育行为之间的联系,以确定是否存在文化适应性,从而提高这一人群中儿童多动症的治疗利用率。
{"title":"Black Mothers of Children With and Without ADHD: Relationships Among Maternal Psychopathology, Parenting Stress, and Parenting Cognitions.","authors":"Heather A Jones, Stephanie A Wilson, Amanda M Parks, Alfonso L Floyd, Annie E Rabinovitch, Chantelle C Miller","doi":"10.1177/10870547241288344","DOIUrl":"10.1177/10870547241288344","url":null,"abstract":"<p><strong>Introduction: </strong>Parents of children with attention-deficit/hyperactivity disorder (ADHD) endorse increased parenting stress and lower levels of parenting efficacy and satisfaction as compared to parents of children without ADHD. Additionally, maternal ADHD and depression differentiate children with and without ADHD, with children with ADHD being more likely to have a mother with psychopathology.</p><p><strong>Method: </strong>With a focus on an understudied population, we investigated the extent to which maternal self-reported ADHD and depression were associated with self-reported parenting stress and parenting cognitions in 70 Black mothers of children with (maternal <i>M</i>age = 35.52, <i>SD</i> = 6.49) and without ADHD (maternal <i>M</i>age = 35.39, <i>SD</i> = 6.53) recruited from a metropolitan area in the southeastern United States.</p><p><strong>Results: </strong>Analyses indicated that Black mothers of children with ADHD reported higher levels of parenting stress, lower levels of parenting efficacy, and lower levels of parenting satisfaction. However, there were no significant differences between groups on measures of maternal ADHD or depression. Maternal depression significantly accounted for variability in both parenting satisfaction and parenting stress beyond child ADHD and maternal education. With maternal depression in the models, the association between maternal ADHD and parenting stress and parenting satisfaction lost significance.</p><p><strong>Discussion: </strong>Given the racial disparities in the treatment of ADHD, future research should focus on investigating the linkages between maternal depression, parenting stress, parenting satisfaction, and parenting behaviors in Black mothers in order to delineate whether there are cultural adaptations that may improve treatment utilization rates for child ADHD within this population.</p>","PeriodicalId":15237,"journal":{"name":"Journal of Attention Disorders","volume":" ","pages":"29-41"},"PeriodicalIF":2.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142377851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Causality Between ADHD, ASD, and CVDs: A Two-Step, Two-Sample Mendelian Randomization Investigation. 多动症、自闭症和心血管疾病之间的因果关系:两步双样本孟德尔随机调查。
IF 2.7 3区 医学 Q2 PSYCHIATRY Pub Date : 2025-01-01 Epub Date: 2024-10-14 DOI: 10.1177/10870547241288741
Zequn Zheng, Dihui Cai

Background: While observational studies have established a connection between attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and heightened risk for cardiovascular diseases (CVD), the causal relationships are not well-defined. This study is designed to examine the causality between ASD, ADHD, and CVD risk as well as investigate the mediating factors through which ADHD and ASD influence CVD.

Methods and results: Leveraging two-sample Mendelian randomization (MR) approaches and large scale GWAS summary stats, we examined underlying causal links between ASD and ADHD and the risk of CVDs. The analysis indicated that ADHD was related to an increased likelihood of developing coronary heart disease (OR [95% CI] 1.12 [1.03, 1.21], p = .008), heart failure (OR [95% CI] 1.14 [1.07, 1.22], p = 1.45 × 10-4), and large-artery stroke (OR [95% CI] 1.35 [1.09, 1.66], p = .005). In parallel, ASD showed a correlation with a greater atrial fibrillation risk (OR [95% CI] 1.09 [1.03, 1.16], p = .005] and heart failure (OR [95% CI] 1.11 [1.04, 1.19], p = .004). Additionally, we explored the mediating role of CVD risk factors through two-step MR and multivariable MR, highlighting the possible role of smoking, prescription opioid use, triglycerides, education, income, Townsend deprivation index, and obesity in the causal association of ADHD, ASD, on CVDs.

Conclusion: This MR study highlights the necessity for rigorous cardiovascular surveillance and interventions to decrease adverse cardiovascular events in people with ADHD or ASD by preventing identified mediating risk factors.

背景:尽管观察性研究已证实注意缺陷多动障碍(ADHD)、自闭症谱系障碍(ASD)与心血管疾病(CVD)风险增加之间存在联系,但其因果关系尚未明确。本研究旨在探讨自闭症谱系障碍(ASD)、多动症(ADHD)与心血管疾病风险之间的因果关系,并研究多动症(ADHD)和自闭症谱系障碍(ASD)影响心血管疾病的中介因素:利用双样本孟德尔随机化(MR)方法和大规模 GWAS 总结统计,我们研究了 ASD 和 ADHD 与心血管疾病风险之间的潜在因果关系。分析表明,ADHD 与冠心病(OR [95% CI] 1.12 [1.03, 1.21],p = .008)、心力衰竭(OR [95% CI] 1.14 [1.07, 1.22],p = 1.45 × 10-4)和大动脉中风(OR [95% CI] 1.35 [1.09, 1.66],p = .005)的发病可能性增加有关。同时,ASD 与更高的心房颤动风险(OR [95% CI] 1.09 [1.03, 1.16],p = .005)和心力衰竭(OR [95% CI] 1.11 [1.04, 1.19],p = .004)相关。此外,我们还通过两步MR和多变量MR探讨了心血管疾病风险因素的中介作用,强调了吸烟、处方阿片类药物使用、甘油三酯、教育、收入、汤森剥夺指数和肥胖在ADHD、ASD与心血管疾病的因果关系中可能发挥的作用:这项磁共振研究强调了对心血管进行严格监测和干预的必要性,以通过预防已确定的中介风险因素来减少多动症或 ASD 患者的不良心血管事件。
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引用次数: 0
A Randomized Controlled Trial of the Effects of Organizational Skills Training on Children With Attention Deficit Hyperactivity Disorder in China. 组织能力培训对中国注意力缺陷多动障碍儿童影响的随机对照试验》。
IF 2.7 3区 医学 Q2 PSYCHIATRY Pub Date : 2025-01-01 Epub Date: 2024-10-21 DOI: 10.1177/10870547241289848
Xin-Xin Huang, Li-Zhen Zheng, Qin-Fang Qian, Yan Huang, Yan-Xia Wang, Ping Ou

Background: In addition to attention and hyperactivity problems, children with attention deficit hyperactivity disorder (ADHD) have poorer organizational skills needed to manage time and materials. This study examines the improvement of organizational skills in children with ADHD by studying organizational skills training (OST).

Methods: This was a prospective, randomized controlled trial. Between September 2023 and January 2024, 70 children with a diagnosis of ADHD and at least one domain of executive dysfunction (EF) were divided into two groups. The conventional group was treated with medication, biofeedback, and behavioral interventions based on the children's actual condition. The OST group received OST in addition to the conventional group.

Results: The mean age of the children was 8.33 ± 1.62 years. A total of 66 children completed the intervention and follow-up, 32 in the conventional group and 34 in the OST group. There were no differences between the two groups of children in terms of their preintervention scores on the BRIEF, SNAP-IV, or IVA-CPT. Postintervention scores on the behavioral scales decreased (p < .05), and IVA-CPT scores increased (p < .05) in both groups compared with those in the preintervention period. The OST group had a lower BRIEF (p = .019) and SNAP-IV Attention deficit subscale (p = .046) and a higher IVA-CPT Attention deficit Index (p = .032) than the conventional group after the intervention. The percentage of children with a normal BRIEF total score in the OST group was 79.41% (27/34) after the intervention, which was greater than the 37.50% (12/32) in the conventional group (p = .001). Compared with the OST group, children in the conventional group were at greater risk of having BRIEF scores that remained abnormal after the intervention. Analysis of covariance revealed a statistically significant effect of group (p = .008), preintervention BRIEF (p < .001), and participation score (p = .036) on postintervention BRIEF.

Conclusion: OST can further improve organizational skills in daily life in children with ADHD while improving core symptoms of attention deficit in addition to conventional treatment. The effect of OST on BRIEF is also influenced by the child's BRIEF status at the baseline level and the level of cooperation during the intervention.

Trial registration: The randomized controlled trial registration number was ChiCTR2300075744.

背景:患有注意力缺陷多动障碍(ADHD)的儿童除了注意力和多动问题外,管理时间和材料所需的组织能力也较差。本研究通过组织能力训练(OST)来探讨如何提高多动症儿童的组织能力:这是一项前瞻性随机对照试验。2023 年 9 月至 2024 年 1 月期间,70 名被诊断为多动症且至少有一个执行功能障碍(EF)的儿童被分为两组。常规组根据儿童的实际情况接受药物、生物反馈和行为干预治疗。OST组在常规组的基础上接受OST治疗:儿童的平均年龄为(8.33 ± 1.62)岁。共有 66 名儿童完成了干预和随访,其中常规组 32 名,OST 组 34 名。两组儿童在干预前的 BRIEF、SNAP-IV 或 IVA-CPT 评分上没有差异。干预后,行为量表得分下降(p p = .019),SNAP-IV 注意力缺陷分量表得分下降(p = .046),IVA-CPT 注意力缺陷指数(p = .032)高于常规组。干预后,OST 组 BRIEF 总分正常的儿童比例为 79.41%(27/34),高于常规组的 37.50%(12/32)(p = .001)。与 OST 组相比,常规组儿童在干预后出现 BRIEF 评分异常的风险更大。协方差分析显示,组别(p = .008)、干预前 BRIEF(p p = .036)对干预后 BRIEF 的影响具有统计学意义:结论:在常规治疗的基础上,OST 可以进一步提高多动症儿童在日常生活中的组织能力,同时改善注意力缺陷的核心症状。OST对BRIEF的影响还受到儿童基线水平的BRIEF状况和干预期间合作程度的影响:随机对照试验注册号为ChiCTR2300075744。
{"title":"A Randomized Controlled Trial of the Effects of Organizational Skills Training on Children With Attention Deficit Hyperactivity Disorder in China.","authors":"Xin-Xin Huang, Li-Zhen Zheng, Qin-Fang Qian, Yan Huang, Yan-Xia Wang, Ping Ou","doi":"10.1177/10870547241289848","DOIUrl":"10.1177/10870547241289848","url":null,"abstract":"<p><strong>Background: </strong>In addition to attention and hyperactivity problems, children with attention deficit hyperactivity disorder (ADHD) have poorer organizational skills needed to manage time and materials. This study examines the improvement of organizational skills in children with ADHD by studying organizational skills training (OST).</p><p><strong>Methods: </strong>This was a prospective, randomized controlled trial. Between September 2023 and January 2024, 70 children with a diagnosis of ADHD and at least one domain of executive dysfunction (EF) were divided into two groups. The conventional group was treated with medication, biofeedback, and behavioral interventions based on the children's actual condition. The OST group received OST in addition to the conventional group.</p><p><strong>Results: </strong>The mean age of the children was 8.33 ± 1.62 years. A total of 66 children completed the intervention and follow-up, 32 in the conventional group and 34 in the OST group. There were no differences between the two groups of children in terms of their preintervention scores on the BRIEF, SNAP-IV, or IVA-CPT. Postintervention scores on the behavioral scales decreased (<i>p</i> < .05), and IVA-CPT scores increased (<i>p</i> < .05) in both groups compared with those in the preintervention period. The OST group had a lower BRIEF (<i>p</i> = .019) and SNAP-IV Attention deficit subscale (<i>p</i> = .046) and a higher IVA-CPT Attention deficit Index (<i>p</i> = .032) than the conventional group after the intervention. The percentage of children with a normal BRIEF total score in the OST group was 79.41% (27/34) after the intervention, which was greater than the 37.50% (12/32) in the conventional group (<i>p</i> = .001). Compared with the OST group, children in the conventional group were at greater risk of having BRIEF scores that remained abnormal after the intervention. Analysis of covariance revealed a statistically significant effect of group (<i>p</i> = .008), preintervention BRIEF (<i>p</i> < .001), and participation score (<i>p</i> = .036) on postintervention BRIEF.</p><p><strong>Conclusion: </strong>OST can further improve organizational skills in daily life in children with ADHD while improving core symptoms of attention deficit in addition to conventional treatment. The effect of OST on BRIEF is also influenced by the child's BRIEF status at the baseline level and the level of cooperation during the intervention.</p><p><strong>Trial registration: </strong>The randomized controlled trial registration number was ChiCTR2300075744.</p>","PeriodicalId":15237,"journal":{"name":"Journal of Attention Disorders","volume":" ","pages":"128-139"},"PeriodicalIF":2.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142466393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the Relationship of Dietary Intake With Inattention, Hyperactivity, and Impulsivity, Beyond ADHD. 探索膳食摄入与注意力不集中、多动和冲动的关系,超越多动症。
IF 2.7 3区 医学 Q2 PSYCHIATRY Pub Date : 2025-01-01 Epub Date: 2024-11-05 DOI: 10.1177/10870547241293946
Laura Dalnoki, Petra P M Hurks, Jessica S Gubbels, Simone J P M Eussen, Monique Mommers, Carel Thijs

Objectives: This study investigates the association between dietary intake and ADHD diagnosis and its dimensions in adolescents.

Methods: In the KOALA Birth Cohort Study, 810 adolescents aged 16 to 20 years provided information on ADHD diagnosis and completed a food frequency questionnaire. Dietary patterns were extracted using Principal Component Analysis. Parents reported on ADHD symptoms using the Conners' Parent Rating Scale-Revised Short form, and the Impulsivity subscale from the Temperament in Middle Childhood Questionnaire.

Results: The 80 adolescents with ADHD scored higher on the Snacking dietary pattern compared to those without ADHD, while they did not differ on Healthy, Animal-based, Sweet, or Beverage dietary patterns. All ADHD symptom scores (Hyperactivity, Inattention and Impulsivity, and ADHD-index) correlated with increased Snacking. Impulsivity was inversely related to Sweet dietary patterns and positively to Beverage dietary patterns.

Conclusion: The results highlight the importance of considering ADHD dimensions beyond diagnosis in understanding adolescents' dietary intake.

研究目的本研究调查了青少年饮食摄入量与多动症诊断及其各维度之间的关系:在KOALA出生队列研究中,810名16至20岁的青少年提供了有关多动症诊断的信息,并填写了一份食物频率问卷。采用主成分分析法提取饮食模式。家长使用康纳斯家长评定量表-修订版简表和中学生气质问卷中的冲动性分量表报告多动症症状:与非多动症青少年相比,80 名患有多动症的青少年在零食饮食模式上得分更高,而在健康、动物性、甜食或饮料饮食模式上没有差异。所有多动症症状得分(多动、注意力不集中和冲动以及多动症指数)都与零食摄入量的增加相关。冲动与甜食饮食模式成反比,与饮料饮食模式成正比:结论:研究结果表明,在了解青少年的饮食摄入情况时,除了考虑诊断结果外,还必须考虑多动症的其他方面。
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引用次数: 0
Diabetes Glycemic Control in Adults With Type 2 Diabetes Mellitus and ADHD. 2 型糖尿病合并多动症成人的血糖控制。
IF 2.7 3区 医学 Q2 PSYCHIATRY Pub Date : 2025-01-01 Epub Date: 2024-10-10 DOI: 10.1177/10870547241288720
Dahlia Leshno, Liat Lev Shalem, Revital Perlov Gavze, Moshe Leshno

Introduction: Persistence in treatment is important in balancing diabetes and preventing complications. ADHD impairs quality of life and functioning in many areas of life. The aim of this study is to evaluate the possible association of ADHD and diabetes glycemic control among adults with type 2 diabetes mellitus (T2DM).

Methods: All data were obtained from Maccabi Healthcare Services (MHS) automated databases. This retrospective cross-sectional study uses electronic medical records from the Maccabi Healthcare Services database during the years 2010 to 2020. Using a propensity score with the variables of age, gender, and duration of diabetes, we compared a group of 1,582 patients with T2DM and ADHD to 1,582 patients with T2DM and without ADHD. We used a t-test to compare continuous variables and a Mann-Whitney U test for non-parametric testing. In addition, we used multivariate logistic regression with a cutoff of several HbA1c values in T2DM patients with and without ADHD during 2019 to 2020. The proportion of patients with HbA1c values above 10%, 9%, and 8% in the group of patients with ADHD was 4.7 to 5.9 times higher than in patients without ADHD. In addition, the OR in the multivariate logistic regression was 4.2 (95% CI [2.5, 6.8]), 4.3 (95% CI [3.1, 6.1]), and 2.7 (95% CI [2.2, 3.4]) for cutoff of HbA1c of 10%, 9%, and 8%, respectively.

Conclusion: Patients with co-morbid ADHD and T2DM have a higher incidence of poor glycemic control. The findings extend the knowledge on the relationship between ADHD and diabetes and highlight the need for further research to improve treatment.

介绍:坚持治疗对于平衡糖尿病和预防并发症非常重要。多动症会损害生活质量和许多生活领域的功能。本研究旨在评估多动症与 2 型糖尿病(T2DM)成人患者的血糖控制之间可能存在的关联:所有数据均来自马卡比医疗保健服务(Maccabi Healthcare Services,MHS)的自动数据库。这项回顾性横断面研究使用了马卡比医疗保健服务数据库中 2010 年至 2020 年的电子病历。通过使用年龄、性别和糖尿病病程等变量进行倾向评分,我们将 1582 名患有 T2DM 和多动症的患者与 1582 名患有 T2DM 但不患有多动症的患者进行了比较。我们使用 t 检验比较连续变量,使用 Mann-Whitney U 检验进行非参数检验。此外,我们还使用了多变量逻辑回归,以2019年至2020年期间有多动症和无多动症的T2DM患者的几个HbA1c值为临界值。多动症患者组中HbA1c值高于10%、9%和8%的患者比例是无多动症患者的4.7至5.9倍。此外,在多变量逻辑回归中,HbA1c 临界值为 10%、9% 和 8% 的 OR 分别为 4.2(95% CI [2.5,6.8])、4.3(95% CI [3.1,6.1])和 2.7(95% CI [2.2,3.4]):结论:合并多动症和 T2DM 的患者血糖控制不佳的发生率较高。研究结果拓展了人们对多动症与糖尿病之间关系的认识,并强调了进一步研究以改善治疗的必要性。
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引用次数: 0
Examining the Association Between Adverse Childhood Experiences and ADHD in School-Aged Children Following the COVID-19 Pandemic. 研究 COVID-19 大流行后学龄儿童的不良童年经历与多动症之间的关系。
IF 2.7 3区 医学 Q2 PSYCHIATRY Pub Date : 2025-01-01 Epub Date: 2024-10-18 DOI: 10.1177/10870547241290673
Emma Boswell, Elizabeth Crouch, Cassie Odahowski, Peiyin Hung

Background: Adverse childhood experiences (ACEs) have long been associated with attention-deficit/hyperactive disorder (ADHD) diagnoses in children; but the data used is now over 6 years old (from 2017 to 2018). Understanding the current landscape of their prevalence and association is needed to capture evolving social, environmental, and economic conditions, and ensure interventions remain relevant to addressing current childhood trauma.

Objective: This study provides an updated analysis of the association between ACEs and ADHD using post-acute-COVID-19 pandemic data.

Participants and setting: This cross-sectional study of 10,518 children aged 5 to 17 years old derived data from the 2021 to 2022 National Health Interview Survey (NHIS).

Methods: Differences in the prevalence of number (0, 1-3, or 4+) and type of ACEs by ADHD diagnosis were evaluated using Rao-Scott chi-square tests and multivariable logistic regression. All analyses incorporate complex survey weights.

Results: In 2021 to 2022, 2,457 (23.3%) of children experienced ACEs and 1,115 (9.9%) had an ADHD diagnosis. Children with ADHD were more likely to experience every type of ACE and were more likely to have 1 to 3 or 4+ ACEs than children without ADHD. Children with 4+ ACEs had higher odds of having an ADHD diagnosis (aOR: 3.44, 95% CI [2.64, 4.49]) than children without ACEs. Male children, children with fair or poor health, and children living in rural counties were more likely to have an ADHD diagnosis, while children of color and uninsured children were less likely. We found the odds ratio of ADHD diagnosis for children with four or more ACEs, compared to those without ACEs, slightly lower than found in Brown et al., 2017's estimate of 3.97 (CI [3.29, 4.80]). These results suggest a consistent association between ACEs and ADHD when comparing pre-COVID data to our post-acute-COVID results.

Conclusions: These findings highlight the need for clinicians to consider traumatic stress in ADHD screening. Policymakers and early childhood organizations should encourage early screening and intervention for ACEs to reduce the impacts of ADHD diagnoses.

背景:长期以来,儿童不良童年经历(ACEs)一直与儿童注意力缺陷/多动障碍(ADHD)的诊断有关;但现在所使用的数据已超过 6 年(从 2017 年到 2018 年)。需要了解其流行率和相关性的现状,以掌握不断变化的社会、环境和经济条件,并确保干预措施始终与解决当前的儿童创伤问题相关:本研究利用 COVID-19 大流行后的数据,对 ACE 与多动症之间的关联进行了最新分析:这项横断面研究的 10,518 名 5 至 17 岁儿童的数据来自 2021 年至 2022 年的全国健康访谈调查(NHIS):方法:使用拉奥-斯科特卡方检验和多变量逻辑回归评估了ADHD诊断中ACE数量(0、1-3或4+)和类型的流行率差异。所有分析都采用了复杂的调查权重:在 2021 年至 2022 年期间,2,457 名儿童(23.3%)经历过 ACE,1,115 名儿童(9.9%)被诊断患有多动症。与没有多动症的儿童相比,患有多动症的儿童更有可能经历各种类型的 ACE,并且更有可能经历 1 到 3 次或 4 次以上的 ACE。与没有经历过 ACE 的儿童相比,经历过 4+ ACE 的儿童被诊断为多动症的几率更高(aOR:3.44,95% CI [2.64,4.49])。男性儿童、健康状况一般或较差的儿童以及居住在农村地区的儿童更有可能被诊断出患有多动症,而有色人种儿童和没有保险的儿童则更有可能被诊断出患有多动症。我们发现,与无 ACE 的儿童相比,有四次或四次以上 ACE 的儿童被诊断为多动症的几率比略低于 Brown 等人 2017 年估计的 3.97(CI [3.29, 4.80])。这些结果表明,将COVID前的数据与COVID后的结果进行比较,ACE与ADHD之间存在一致的关联:这些发现强调了临床医生在筛查多动症时考虑创伤性压力的必要性。政策制定者和儿童早期组织应鼓励对 ACE 进行早期筛查和干预,以减少 ADHD 诊断的影响。
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引用次数: 0
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Journal of Attention Disorders
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