Pub Date : 2026-03-01Epub Date: 2025-12-16DOI: 10.1177/10870547251397034
Shaquib Al Hasan, Meena Murugappan, Sarah Westberg, Stephen A Contag, Tanya Melnik, Abhijeet Rajpurohit, Joel F Farley
<p><strong>Objective: </strong>Although studies examining utero exposure to prescription stimulants have suggested an association with maternal and fetal adverse events, results have been inconsistent. Therefore, clinicians may not have clear guidance about stimulant use during pregnancy. The objective of this study was to evaluate maternal and fetal risks of prescription stimulant exposure among women of reproductive age throughout the continuum of pregnancy in a large, commercially insured United States population.</p><p><strong>Methods: </strong>We used a large administrative claims database from 2013 to 2021 to compare stimulant exposed pregnancies to a matched cohort of non-exposed pregnancies. Stimulant exposed pregnancies included early stimulant use, defined as one or more stimulant prescription fills at any point during the first trimester and continued exposure, defined as continuation into the second or third trimesters. Relative risk regression models were used to compare the risk of each outcome between exposure and duration of exposure cohorts matched on clinical conditions and medication used by 1:1 greedy neighbor propensity score matching.</p><p><strong>Results: </strong>Among a sample of 10,265 matched patients, early stimulant exposure (first trimester only) was associated with a higher likelihood of live birth (RR = 1.08, 95% CI [1.06, 1.10]) and lower risks of spontaneous abortion (RR = 0.69, 95% CI [0.64, 0.76]) and preterm birth (RR = 0.75, 95% CI [0.62, 0.90]) compared with no stimulant exposure. Stillbirth and ectopic pregnancy did not differ. When exposure continued into the second or third trimesters, risks increased for placental abruption (RR = 1.63, 95% CI [1.03, 2.57]), pre-eclampsia (RR = 1.42, 95% CI [1.19, 1.69]), gestational hypertension (RR = 1.37, 95% CI [1.16, 1.61]), and preterm birth (RR = 1.34, 95% CI [1.12, 1.62]) compared with non-exposed pregnancies. Stillbirth was not significantly different in this comparison (RR = 1.42, 95% CI [0.76, 2.67]). Direct comparison of continued versus early exposure highlighted more pronounced risks with continuation: higher stillbirth (RR = 3.54, 95% CI [1.48, 8.44]), spontaneous abortion (RR = 1.53, 95% CI [1.38, 1.68]), preterm birth (RR = 1.86, 95% CI [1.51, 2.28]), placental abruption (RR = 1.78, 95% CI [1.11, 2.84]), and pre-eclampsia (RR = 1.33, 95% CI [1.12, 1.59]). Small-for-gestational-age infants were also more frequent in the continuation group (RR = 1.47, 95% CI [1.12, 1.92]). Analyses stratified by stimulant class (amphetamine vs methylphenidate containing) were directionally consistent with the overall findings.</p><p><strong>Conclusions: </strong>Although early stimulant exposure was not associated with increases in maternal or fetal risk, our study suggests that continuation of stimulants into trimesters 2 and/or 3 may increase some pregnancy complications including stillbirth, preterm birth, hypertensive disorders of pregnancy, and placental abruption. Cl
{"title":"Prescription Stimulant Continuation in Pregnancy and Birth Outcomes.","authors":"Shaquib Al Hasan, Meena Murugappan, Sarah Westberg, Stephen A Contag, Tanya Melnik, Abhijeet Rajpurohit, Joel F Farley","doi":"10.1177/10870547251397034","DOIUrl":"10.1177/10870547251397034","url":null,"abstract":"<p><strong>Objective: </strong>Although studies examining utero exposure to prescription stimulants have suggested an association with maternal and fetal adverse events, results have been inconsistent. Therefore, clinicians may not have clear guidance about stimulant use during pregnancy. The objective of this study was to evaluate maternal and fetal risks of prescription stimulant exposure among women of reproductive age throughout the continuum of pregnancy in a large, commercially insured United States population.</p><p><strong>Methods: </strong>We used a large administrative claims database from 2013 to 2021 to compare stimulant exposed pregnancies to a matched cohort of non-exposed pregnancies. Stimulant exposed pregnancies included early stimulant use, defined as one or more stimulant prescription fills at any point during the first trimester and continued exposure, defined as continuation into the second or third trimesters. Relative risk regression models were used to compare the risk of each outcome between exposure and duration of exposure cohorts matched on clinical conditions and medication used by 1:1 greedy neighbor propensity score matching.</p><p><strong>Results: </strong>Among a sample of 10,265 matched patients, early stimulant exposure (first trimester only) was associated with a higher likelihood of live birth (RR = 1.08, 95% CI [1.06, 1.10]) and lower risks of spontaneous abortion (RR = 0.69, 95% CI [0.64, 0.76]) and preterm birth (RR = 0.75, 95% CI [0.62, 0.90]) compared with no stimulant exposure. Stillbirth and ectopic pregnancy did not differ. When exposure continued into the second or third trimesters, risks increased for placental abruption (RR = 1.63, 95% CI [1.03, 2.57]), pre-eclampsia (RR = 1.42, 95% CI [1.19, 1.69]), gestational hypertension (RR = 1.37, 95% CI [1.16, 1.61]), and preterm birth (RR = 1.34, 95% CI [1.12, 1.62]) compared with non-exposed pregnancies. Stillbirth was not significantly different in this comparison (RR = 1.42, 95% CI [0.76, 2.67]). Direct comparison of continued versus early exposure highlighted more pronounced risks with continuation: higher stillbirth (RR = 3.54, 95% CI [1.48, 8.44]), spontaneous abortion (RR = 1.53, 95% CI [1.38, 1.68]), preterm birth (RR = 1.86, 95% CI [1.51, 2.28]), placental abruption (RR = 1.78, 95% CI [1.11, 2.84]), and pre-eclampsia (RR = 1.33, 95% CI [1.12, 1.59]). Small-for-gestational-age infants were also more frequent in the continuation group (RR = 1.47, 95% CI [1.12, 1.92]). Analyses stratified by stimulant class (amphetamine vs methylphenidate containing) were directionally consistent with the overall findings.</p><p><strong>Conclusions: </strong>Although early stimulant exposure was not associated with increases in maternal or fetal risk, our study suggests that continuation of stimulants into trimesters 2 and/or 3 may increase some pregnancy complications including stillbirth, preterm birth, hypertensive disorders of pregnancy, and placental abruption. Cl","PeriodicalId":15237,"journal":{"name":"Journal of Attention Disorders","volume":" ","pages":"315-328"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145762737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2026-01-07DOI: 10.1177/10870547251407731
Armagan Aral, Gizem Gerdan, Yılmaz Orhun Gürlük
ADHD is complex neurodevelopmental disorder that causes considerable individual and social difficulties, creating significant parental stress. This study aimed to examine the indirect associations between parental stress and child irritability through two sequential parenting mechanisms: experiential avoidance and negative parent-child relationship, within a sample of school-aged children with ADHD (ages 6-12). Using a two-wave longitudinal serial path analysis based on parent-reported data collected at two time points 1-month apart (Time 1 and Time 2), the study investigated whether early parental stress predicted subsequent child irritability via its influence on experiential avoidance and the quality of the parent-child relationship. Findings supported the hypothesized model. More precisely, higher parental stress was associated with greater experiential avoidance, which in turn predicted more negative parent-child relationship, ultimately resulting in elevated child irritability. Longitudinal serial mediation effects confirmed that all Time 1 variables significantly predicted corresponding Time 2 outcomes across the proposed sequential pathway. Notably, the model explained 41.1% of the variance in child irritability at Time 2, underscoring how stress-related disruptions in experiential avoidance and parent-child relationship can affect child irritability even over a short period of time. Taken together, these findings provide empirical support for a stress-driven sequence of parental mechanisms through which parental stress may contribute to child irritability in ADHD. In this context, interventions targeting parental experiential avoidance and improving the quality of parent-child relationship may help mitigate the early development of irritability in children with ADHD. Clinical implications are discussed.
{"title":"Parental Stress and Child Irritability in ADHD: A Two-Wave Longitudinal Serial Mediation Model via Experiential Avoidance and Negative Parent-Child Relationship.","authors":"Armagan Aral, Gizem Gerdan, Yılmaz Orhun Gürlük","doi":"10.1177/10870547251407731","DOIUrl":"10.1177/10870547251407731","url":null,"abstract":"<p><p>ADHD is complex neurodevelopmental disorder that causes considerable individual and social difficulties, creating significant parental stress. This study aimed to examine the indirect associations between parental stress and child irritability through two sequential parenting mechanisms: experiential avoidance and negative parent-child relationship, within a sample of school-aged children with ADHD (ages 6-12). Using a two-wave longitudinal serial path analysis based on parent-reported data collected at two time points 1-month apart (Time 1 and Time 2), the study investigated whether early parental stress predicted subsequent child irritability via its influence on experiential avoidance and the quality of the parent-child relationship. Findings supported the hypothesized model. More precisely, higher parental stress was associated with greater experiential avoidance, which in turn predicted more negative parent-child relationship, ultimately resulting in elevated child irritability. Longitudinal serial mediation effects confirmed that all Time 1 variables significantly predicted corresponding Time 2 outcomes across the proposed sequential pathway. Notably, the model explained 41.1% of the variance in child irritability at Time 2, underscoring how stress-related disruptions in experiential avoidance and parent-child relationship can affect child irritability even over a short period of time. Taken together, these findings provide empirical support for a stress-driven sequence of parental mechanisms through which parental stress may contribute to child irritability in ADHD. In this context, interventions targeting parental experiential avoidance and improving the quality of parent-child relationship may help mitigate the early development of irritability in children with ADHD. Clinical implications are discussed.</p>","PeriodicalId":15237,"journal":{"name":"Journal of Attention Disorders","volume":" ","pages":"342-353"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145910658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-25DOI: 10.1177/10870547261421983
Clare O'Toole, John Finlayson, Stuart Johnstone, Kate Croaker
Aim: This study aimed to provide a representative indication of the accessibility of both adult and child ADHD assessments in Australia for psychologists, psychiatrists, and paediatricians. Accessibility was considered in terms of clinician availability, wait times for an initial session, initial session costs, and total assessment costs across Australian states and territories, remoteness areas, and socioeconomic ranges.
Methods: Using a secret shopper design, researchers posed as potential consumers seeking an ADHD assessment for themselves and/or their child. A total of 736 clinicians were contacted via telephone between May and August 2024.
Results: Fifty-nine percent of clinicians responded, and 49.8% of respondents were available to book an ADHD assessment. The average wait times for psychologists, psychiatrists, and paediatricians were 7, 16, and 31 weeks, respectively (Mdn = 3, 15, and 26; IQR = 7, 16, and 31). The average initial session costs and estimated total assessment costs were $266 and $1,622 for psychologists (Mdn = 250 and 1,625; IQR = 57 and 929), $748 and $1,163 for psychiatrists (Mdn = 750 and 1,086; IQR = 340 and 555), and $500 and $598 for paediatricians (Mdn = 495 and 585; IQR = 123 and 739).
Conclusion: This study identified substantial barriers to ADHD assessment accessibility in Australia. Low clinician availability, long wait times, and high costs for assessments are all factors contributing to healthcare access inequality. Policy changes and investment, as well as further research into contributing factors, are needed to improve availability and accessibility.
{"title":"Accessibility of ADHD Assessments in Australia: A Secret Shopper Study.","authors":"Clare O'Toole, John Finlayson, Stuart Johnstone, Kate Croaker","doi":"10.1177/10870547261421983","DOIUrl":"https://doi.org/10.1177/10870547261421983","url":null,"abstract":"<p><strong>Aim: </strong>This study aimed to provide a representative indication of the accessibility of both adult and child ADHD assessments in Australia for psychologists, psychiatrists, and paediatricians. Accessibility was considered in terms of clinician availability, wait times for an initial session, initial session costs, and total assessment costs across Australian states and territories, remoteness areas, and socioeconomic ranges.</p><p><strong>Methods: </strong>Using a secret shopper design, researchers posed as potential consumers seeking an ADHD assessment for themselves and/or their child. A total of 736 clinicians were contacted via telephone between May and August 2024.</p><p><strong>Results: </strong>Fifty-nine percent of clinicians responded, and 49.8% of respondents were available to book an ADHD assessment. The average wait times for psychologists, psychiatrists, and paediatricians were 7, 16, and 31 weeks, respectively (Mdn = 3, 15, and 26; IQR = 7, 16, and 31). The average initial session costs and estimated total assessment costs were $266 and $1,622 for psychologists (Mdn = 250 and 1,625; IQR = 57 and 929), $748 and $1,163 for psychiatrists (Mdn = 750 and 1,086; IQR = 340 and 555), and $500 and $598 for paediatricians (Mdn = 495 and 585; IQR = 123 and 739).</p><p><strong>Conclusion: </strong>This study identified substantial barriers to ADHD assessment accessibility in Australia. Low clinician availability, long wait times, and high costs for assessments are all factors contributing to healthcare access inequality. Policy changes and investment, as well as further research into contributing factors, are needed to improve availability and accessibility.</p>","PeriodicalId":15237,"journal":{"name":"Journal of Attention Disorders","volume":" ","pages":"10870547261421983"},"PeriodicalIF":2.2,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147306363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-12DOI: 10.1177/10870547261419885
Seyma Soyal, Baris Metin
Objective: Attention-deficit/hyperactivity disorder (ADHD) is associated not only with cognitive impairments but also with deficits in social cognitive abilities, including empathy. Although attention and empathy have been individually studied in children with ADHD, the link between performance-based attention measures and empathy remains underexplored. Thus, this study examined the relationship between attention performance and empathy in children diagnosed with ADHD.
Method: The sample included 53 children aged 7 to 12, consisting of 27 children diagnosed with ADHD and 26 typically developing control group. All participants were recruited from educational and clinical settings. Attention was measured using a computer-based Go/No-Go task, and empathy was assessed using the Reading the Mind in the Eyes Test (RMET). ADHD symptom severity was assessed using the Turgay DSM-IV-Based Disruptive Behavior Disorders Rating Scale (T-DSM-IV-S).
Results: Children with ADHD made significantly more omission errors and scored lower on RMET than typically developing group. Significant negative correlations were found between RMET total score and omission errors and inattention scores. Regression analyses further supported these associations by indicating that attention-related variables significantly predicted empathy performance.
Conclusion: Attention performance is closely associated with empathy in children with ADHD. These findings underscore the need for early and integrative interventions targeting both attentional and socio-cognitive dimensions in children with ADHD.
{"title":"The Association Between Attention Performance and Empathy in Children Diagnosed with ADHD.","authors":"Seyma Soyal, Baris Metin","doi":"10.1177/10870547261419885","DOIUrl":"https://doi.org/10.1177/10870547261419885","url":null,"abstract":"<p><strong>Objective: </strong>Attention-deficit/hyperactivity disorder (ADHD) is associated not only with cognitive impairments but also with deficits in social cognitive abilities, including empathy. Although attention and empathy have been individually studied in children with ADHD, the link between performance-based attention measures and empathy remains underexplored. Thus, this study examined the relationship between attention performance and empathy in children diagnosed with ADHD.</p><p><strong>Method: </strong>The sample included 53 children aged 7 to 12, consisting of 27 children diagnosed with ADHD and 26 typically developing control group. All participants were recruited from educational and clinical settings. Attention was measured using a computer-based Go/No-Go task, and empathy was assessed using the Reading the Mind in the Eyes Test (RMET). ADHD symptom severity was assessed using the Turgay DSM-IV-Based Disruptive Behavior Disorders Rating Scale (T-DSM-IV-S).</p><p><strong>Results: </strong>Children with ADHD made significantly more omission errors and scored lower on RMET than typically developing group. Significant negative correlations were found between RMET total score and omission errors and inattention scores. Regression analyses further supported these associations by indicating that attention-related variables significantly predicted empathy performance.</p><p><strong>Conclusion: </strong>Attention performance is closely associated with empathy in children with ADHD. These findings underscore the need for early and integrative interventions targeting both attentional and socio-cognitive dimensions in children with ADHD.</p>","PeriodicalId":15237,"journal":{"name":"Journal of Attention Disorders","volume":" ","pages":"10870547261419885"},"PeriodicalIF":2.2,"publicationDate":"2026-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146180078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-12DOI: 10.1177/10870547261416467
Mareike Altgassen, Helena Heinrich, Marc-Andreas Edel
This study investigated the effects of the encoding strategy episodic future thinking on prospective memory performance (i.e., remembering to execute intended actions in the future) in individuals with a diagnosis of Attention Deficit Hyperactivity Disorder (ADHD) by community providers. Individuals with ADHD often have difficulties to plan and execute delayed intentions in everyday life; thus, they show reduced prospective memory performance. Several studies indicate that engaging in episodic future thinking (i.e., mentally imagining executing the planned activity) during intention formation can improve prospective memory performance in typically developing populations in lab-based settings. To assess the execution of everyday intentions, we requested participants to perform the diary task. Thirty-two adults with ADHD and 31 controls were allocated to an episodic future thinking encoding condition and 31 adults with ADHD and 33 controls to a standard encoding condition. Analyses of variance revealed significant main effects of group and of encoding condition. Overall, controls remembered to execute more intentions than individuals with ADHD. Across groups, episodic future thinking increased the realization of intentions as compared to the standard encoding condition; however, this effect was no longer significant when verbal ability was statistically controlled. There was no significant interaction effect. This study replicates earlier findings of reduced intention execution in ADHD and provides preliminary support for episodic future thinking as a strategy to enhance PM in daily life, though its effects may depend on verbal ability, warranting further research.
{"title":"Episodic Future Thinking Improves Everyday Prospective Memory Performance in Adults With a Previous Diagnosis of Attention Deficit Hyperactivity Disorder by Community Providers.","authors":"Mareike Altgassen, Helena Heinrich, Marc-Andreas Edel","doi":"10.1177/10870547261416467","DOIUrl":"https://doi.org/10.1177/10870547261416467","url":null,"abstract":"<p><p>This study investigated the effects of the encoding strategy episodic future thinking on prospective memory performance (i.e., remembering to execute intended actions in the future) in individuals with a diagnosis of Attention Deficit Hyperactivity Disorder (ADHD) by community providers. Individuals with ADHD often have difficulties to plan and execute delayed intentions in everyday life; thus, they show reduced prospective memory performance. Several studies indicate that engaging in episodic future thinking (i.e., mentally imagining executing the planned activity) during intention formation can improve prospective memory performance in typically developing populations in lab-based settings. To assess the execution of everyday intentions, we requested participants to perform the diary task. Thirty-two adults with ADHD and 31 controls were allocated to an episodic future thinking encoding condition and 31 adults with ADHD and 33 controls to a standard encoding condition. Analyses of variance revealed significant main effects of group and of encoding condition. Overall, controls remembered to execute more intentions than individuals with ADHD. Across groups, episodic future thinking increased the realization of intentions as compared to the standard encoding condition; however, this effect was no longer significant when verbal ability was statistically controlled. There was no significant interaction effect. This study replicates earlier findings of reduced intention execution in ADHD and provides preliminary support for episodic future thinking as a strategy to enhance PM in daily life, though its effects may depend on verbal ability, warranting further research.</p>","PeriodicalId":15237,"journal":{"name":"Journal of Attention Disorders","volume":" ","pages":"10870547261416467"},"PeriodicalIF":2.2,"publicationDate":"2026-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146180075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-12DOI: 10.1177/10870547261416173
Raman Baweja, Fabiana Lopes, Felix M Padilla, Ritika Baweja, Lisa Amaya-Jackson, Daniel A Waschbusch, James G Waxmonsky
Objectives: Attention-deficit/hyperactivity disorder (ADHD) and post-traumatic stress disorder (PTSD) often co-occur in youth, complicating the clinical presentation. However, little is known about how PTSD influences treatment selection or outcomes in youth with ADHD. This study examined prescribing patterns and clinical outcomes among youth with ADHD, with and without comorbid PTSD.
Methods: This retrospective cohort study used electronic health record data from the TriNetX Research Network, including over 714,000 youth (ages 6-18) diagnosed with ADHD (F90), of whom 30,341 (4.25%) also had comorbid PTSD (F43.1). Outcomes included treatment trends, emergency visits, hospitalizations, and subsequent antipsychotic or mood stabilizer prescriptions. Relative risks (RR), hazard ratios (HR), and 95% confidence intervals were calculated using propensity score matching and Cox proportional hazards models adjusted for sociodemographic and psychiatric variables.
Results: Among youth with ADHD, those with comorbid PTSD were older, had more psychiatric comorbidities, and were more likely to receive non-stimulants (RR 1.54, 95% CI [1.51, 1.57]), antidepressants, antipsychotics, mood stabilizers (RRs 1.29-1.70), and psychotherapy (RR 1.55, 95% CI [1.51, 1.60]). Methylphenidate prescriptions were slightly lower (RR 0.97, 95% CI [0.95, 0.99]), while amphetamine use remained stable. Among youth with ADHD and PTSD, CNS stimulants were associated with the most favorable outcomes across all clinical measures, including hospitalizations, emergency visits, and subsequent antipsychotic and mood stabilizer use (aHRs 0.52-0.74), compared with non-stimulants and antidepressants.
Conclusions: Youth with ADHD and PTSD are clinically complex and receive broader treatment interventions. Clinicians appear to de-prioritize stimulants after PTSD diagnosis, despite evidence of superior clinical outcomes. Findings underscore the need for prospective studies and evidence-based treatment guidelines for this high-risk population.
{"title":"Treatment Patterns and Clinical Outcomes in Youth with Comorbid ADHD and PTSD: Insights from Real-World Data.","authors":"Raman Baweja, Fabiana Lopes, Felix M Padilla, Ritika Baweja, Lisa Amaya-Jackson, Daniel A Waschbusch, James G Waxmonsky","doi":"10.1177/10870547261416173","DOIUrl":"https://doi.org/10.1177/10870547261416173","url":null,"abstract":"<p><strong>Objectives: </strong>Attention-deficit/hyperactivity disorder (ADHD) and post-traumatic stress disorder (PTSD) often co-occur in youth, complicating the clinical presentation. However, little is known about how PTSD influences treatment selection or outcomes in youth with ADHD. This study examined prescribing patterns and clinical outcomes among youth with ADHD, with and without comorbid PTSD.</p><p><strong>Methods: </strong>This retrospective cohort study used electronic health record data from the TriNetX Research Network, including over 714,000 youth (ages 6-18) diagnosed with ADHD (F90), of whom 30,341 (4.25%) also had comorbid PTSD (F43.1). Outcomes included treatment trends, emergency visits, hospitalizations, and subsequent antipsychotic or mood stabilizer prescriptions. Relative risks (RR), hazard ratios (HR), and 95% confidence intervals were calculated using propensity score matching and Cox proportional hazards models adjusted for sociodemographic and psychiatric variables.</p><p><strong>Results: </strong>Among youth with ADHD, those with comorbid PTSD were older, had more psychiatric comorbidities, and were more likely to receive non-stimulants (<i>RR</i> 1.54, 95% CI [1.51, 1.57]), antidepressants, antipsychotics, mood stabilizers (RRs 1.29-1.70), and psychotherapy (<i>RR</i> 1.55, 95% CI [1.51, 1.60]). Methylphenidate prescriptions were slightly lower (<i>RR</i> 0.97, 95% CI [0.95, 0.99]), while amphetamine use remained stable. Among youth with ADHD and PTSD, CNS stimulants were associated with the most favorable outcomes across all clinical measures, including hospitalizations, emergency visits, and subsequent antipsychotic and mood stabilizer use (aHRs 0.52-0.74), compared with non-stimulants and antidepressants.</p><p><strong>Conclusions: </strong>Youth with ADHD and PTSD are clinically complex and receive broader treatment interventions. Clinicians appear to de-prioritize stimulants after PTSD diagnosis, despite evidence of superior clinical outcomes. Findings underscore the need for prospective studies and evidence-based treatment guidelines for this high-risk population.</p>","PeriodicalId":15237,"journal":{"name":"Journal of Attention Disorders","volume":" ","pages":"10870547261416173"},"PeriodicalIF":2.2,"publicationDate":"2026-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146180045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-10DOI: 10.1177/10870547251415574
Eric Hengyu Hu, Stephen V Faraone, Paul L Morgan
Background: Prior work reports a relative age effect (RAE), in which children are more likely to be diagnosed with Attention-Deficit/Hyperactivity Disorder (ADHD) if they are relatively younger than their classmates. Yet work reporting a RAE in ADHD diagnosis has analyzed relatively dated samples, has not examined moderation across sociodemographic characteristics, and has largely not examined the RAE in longitudinal analyses. We examined whether entering kindergarten as a relatively younger student increased the likelihood being diagnosed with ADHD across elementary school. We also examined moderation by race and ethnicity, biological sex, socioeconomic status, and home language.
Methods: We analyzed data from the Early Childhood Longitudinal Study-Kindergarten Cohort (ECLS-K: 2011; N = 11,410), a nationally representative cohort. Logistic regression models estimated relations between children's relative age and both grade-specific and cumulative ADHD diagnoses during elementary school. Discrete-time event history logit regression models examined the timing of ADHD diagnosis from kindergarten through fifth grade. Interaction terms assessed moderation by sociodemographic characteristics.
Results: We generally failed to observe evidence of a RAE, either cumulatively or within specific grades. Discrete-time event models indicated no significant relations between relative age and timing of ADHD diagnosis. Moderation analyses identified isolated interactions, indicating the possibility of a specific RAE for Black children and those from non-English-speaking homes in select grades. However, these predicted effects were not consistently observed and did not survive correction for multiple comparisons.
Conclusions: In contrast to prior work analyzing older datasets, we failed to observe a RAE in U.S. elementary schools. Our finding suggest that relatively younger children attending U.S. elementary schools are not at increased likelihood for ADHD diagnosis.
背景:先前的研究报告了相对年龄效应(RAE),如果儿童比他们的同学相对年轻,他们更有可能被诊断为注意力缺陷/多动障碍(ADHD)。然而,报告ADHD诊断中RAE的工作分析了相对较旧的样本,没有检查社会人口统计学特征的中庸性,而且在很大程度上没有在纵向分析中检查RAE。我们研究了作为一个相对年轻的学生进入幼儿园是否会增加在小学阶段被诊断为多动症的可能性。我们还研究了种族和民族、生理性别、社会经济地位和母语的适度性。方法:我们分析了来自幼儿纵向研究-幼儿园队列(ECLS-K: 2011; N = 11,410)的数据,这是一个具有全国代表性的队列。Logistic回归模型估计了儿童相对年龄与小学阶段特定年级和累积ADHD诊断之间的关系。离散时间事件史logit回归模型检验了从幼儿园到五年级ADHD诊断的时间。通过社会人口学特征评估适度性的相互作用项。结果:我们一般没有观察到RAE的证据,无论是累积的还是特定等级的。离散时间事件模型显示相对年龄和ADHD诊断时间之间没有显著关系。适度分析确定了孤立的相互作用,表明了特定年级黑人儿童和非英语家庭儿童的特定RAE的可能性。然而,这些预测的效果并没有被一致地观察到,也没有在多次比较的校正中幸存下来。结论:与之前分析旧数据集的工作相反,我们未能观察到美国小学的RAE。我们的发现表明,在美国上小学的年纪相对较小的孩子被诊断为多动症的可能性并没有增加。
{"title":"Younger-for-Grade Children are Not at Greater Likelihood for ADHD Diagnosis During Elementary School: Repeated Evidence of a Null Relative Age Effect.","authors":"Eric Hengyu Hu, Stephen V Faraone, Paul L Morgan","doi":"10.1177/10870547251415574","DOIUrl":"https://doi.org/10.1177/10870547251415574","url":null,"abstract":"<p><strong>Background: </strong>Prior work reports a relative age effect (RAE), in which children are more likely to be diagnosed with Attention-Deficit/Hyperactivity Disorder (ADHD) if they are relatively younger than their classmates. Yet work reporting a RAE in ADHD diagnosis has analyzed relatively dated samples, has not examined moderation across sociodemographic characteristics, and has largely not examined the RAE in longitudinal analyses. We examined whether entering kindergarten as a relatively younger student increased the likelihood being diagnosed with ADHD across elementary school. We also examined moderation by race and ethnicity, biological sex, socioeconomic status, and home language.</p><p><strong>Methods: </strong>We analyzed data from the Early Childhood Longitudinal Study-Kindergarten Cohort (ECLS-K: 2011; <i>N</i> = 11,410), a nationally representative cohort. Logistic regression models estimated relations between children's relative age and both grade-specific and cumulative ADHD diagnoses during elementary school. Discrete-time event history logit regression models examined the timing of ADHD diagnosis from kindergarten through fifth grade. Interaction terms assessed moderation by sociodemographic characteristics.</p><p><strong>Results: </strong>We generally failed to observe evidence of a RAE, either cumulatively or within specific grades. Discrete-time event models indicated no significant relations between relative age and timing of ADHD diagnosis. Moderation analyses identified isolated interactions, indicating the possibility of a specific RAE for Black children and those from non-English-speaking homes in select grades. However, these predicted effects were not consistently observed and did not survive correction for multiple comparisons.</p><p><strong>Conclusions: </strong>In contrast to prior work analyzing older datasets, we failed to observe a RAE in U.S. elementary schools. Our finding suggest that relatively younger children attending U.S. elementary schools are not at increased likelihood for ADHD diagnosis.</p>","PeriodicalId":15237,"journal":{"name":"Journal of Attention Disorders","volume":" ","pages":"10870547251415574"},"PeriodicalIF":2.2,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146157323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-06DOI: 10.1177/10870547251415434
James T Craig, Michael T Sanders, Christina C Moore, Erin Barnett, Kady F Sternberg, Nicole L Breslend, Lauren C Vazquez, Nina Sand-Loud, Mary K Jankowski
Objective: Attention Deficit/Hyperactivity Disorder (ADHD) is a chronic and impairing neurodevelopmental disorder diagnosed in approximately 2% to 4% of preschool-age children and 9% of all children. Behavioral parent training (BPT) and high-quality education are effective treatments for young children with ADHD; however, poor rates of treatment access and participation limit the reach of BPTs to rural and underserved communities. In this study, we tested the newly developed Rural Outreach and ADHD Research-Early Childhood (ROAR-EC) program, a clinician-led, 7-session education and parent training program designed for delivery over telemedicine.
Method: We conducted a pilot RCT to assess the feasibility, acceptability, engagement of mechanism, and exploratory group × time effects of the ROAR-EC program compared to a control group in a sample of 44 children diagnosed with ADHD from a predominantly rural area (ages 3-7; Mage = 4.8; 62% male; 96% White; 89% non-Hispanic/Latinx). Families were randomized into either ROAR-EC or treatment as usual through developmental pediatrics and followed for 24 weeks. Assessed were metrics of feasibility, acceptability, parenting practices, caregiver empowerment, disruptive behaviors, and ADHD symptoms.
Results: Results indicated that ROAR-EC was feasible to implement and acceptable to caregivers. Repeated measures ANOVAs found significant group × time interaction effects in favor of the treatment group compared to control for family empowerment, parenting practices, total behavior problems, impairment, and inattentive symptoms.
Conclusions: This study demonstrated the promise of brief telemedicine programs as feasible, acceptable, and likely beneficial alternatives to traditional BPTs for young children with ADHD in rural and low-resource areas.
{"title":"ROAR-Early Childhood: Pilot Testing a Brief Telemedicine Parent Training Program for Rural Children Diagnosed with ADHD.","authors":"James T Craig, Michael T Sanders, Christina C Moore, Erin Barnett, Kady F Sternberg, Nicole L Breslend, Lauren C Vazquez, Nina Sand-Loud, Mary K Jankowski","doi":"10.1177/10870547251415434","DOIUrl":"https://doi.org/10.1177/10870547251415434","url":null,"abstract":"<p><strong>Objective: </strong>Attention Deficit/Hyperactivity Disorder (ADHD) is a chronic and impairing neurodevelopmental disorder diagnosed in approximately 2% to 4% of preschool-age children and 9% of all children. Behavioral parent training (BPT) and high-quality education are effective treatments for young children with ADHD; however, poor rates of treatment access and participation limit the reach of BPTs to rural and underserved communities. In this study, we tested the newly developed Rural Outreach and ADHD Research-Early Childhood (ROAR-EC) program, a clinician-led, 7-session education and parent training program designed for delivery over telemedicine.</p><p><strong>Method: </strong>We conducted a pilot RCT to assess the feasibility, acceptability, engagement of mechanism, and exploratory group × time effects of the ROAR-EC program compared to a control group in a sample of 44 children diagnosed with ADHD from a predominantly rural area (ages 3-7; <i>M</i><sub>age</sub> = 4.8; 62% male; 96% White; 89% non-Hispanic/Latinx). Families were randomized into either ROAR-EC or treatment as usual through developmental pediatrics and followed for 24 weeks. Assessed were metrics of feasibility, acceptability, parenting practices, caregiver empowerment, disruptive behaviors, and ADHD symptoms.</p><p><strong>Results: </strong>Results indicated that ROAR-EC was feasible to implement and acceptable to caregivers. Repeated measures ANOVAs found significant group × time interaction effects in favor of the treatment group compared to control for family empowerment, parenting practices, total behavior problems, impairment, and inattentive symptoms.</p><p><strong>Conclusions: </strong>This study demonstrated the promise of brief telemedicine programs as feasible, acceptable, and likely beneficial alternatives to traditional BPTs for young children with ADHD in rural and low-resource areas.</p>","PeriodicalId":15237,"journal":{"name":"Journal of Attention Disorders","volume":" ","pages":"10870547251415434"},"PeriodicalIF":2.2,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146131695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01Epub Date: 2025-12-16DOI: 10.1177/10870547251394173
Yudhajit Ain, Simrit Rai, Ann Galbraith, Jonas Buerkner, Jessica R Andrews-Hanna, Brandy L Callahan, Julia W Y Kam
Background: ADHD has been characterised by excessive mind wandering (MW), or thoughts unrelated to the task at hand, with recent findings indicating that ADHD is specifically associated with more unintentional, but not intentional, MW. These two types of MW are also differentially associated with affective well-being. Most existing studies in ADHD, however, mainly rely on retrospective reports of MW tendencies, which are susceptible to memory-related errors and biases. Further, most studies categorise participants based on overall levels of ADHD, instead of accounting for the spectrum and dimensional heterogeneity of ADHD, including inattention and hyperactivity symptom dimensions. Our study aimed to address the knowledge gap regarding the relationship between different types of MW and affective well-being, across different symptom dimensions of ADHD.
Methods: We used ecological momentary assessment to capture participants' momentary attention state (on-task, intentional MW, or unintentional MW) and affective valence, six times daily for 7 days. Using linear mixed-effects modelling to account for inter-individual variance, we tested whether inattention and hyperactivity symptom dimensions of ADHD differentially moderate the relationship between attention states and affective valence.
Results: We found that higher levels of inattention symptoms predicted more negative affect during intentional MW compared to on-task attention; in contrast, higher levels of hyperactivity symptoms predicted more positive affect during intentional MW compared to on-task attention.
Discussion: Together, our results indicate that intentional MW moderates opposing effects of inattention and hyperactivity ADHD symptoms on affective valence. Our findings suggest that intentional MW - and not just unintentional MW - may also play a role in affective or behavioural outcomes associated with ADHD symptomatology, and highlight the importance of considering the heterogeneity of ADHD symptomatology, as well as the distinction between intentional and unintentional MW, in future ADHD research.
{"title":"Inattention and Hyperactivity Symptom Dimensions of ADHD Differentially Moderate the Relationship Between Concurrent Attention States and Affective Valence.","authors":"Yudhajit Ain, Simrit Rai, Ann Galbraith, Jonas Buerkner, Jessica R Andrews-Hanna, Brandy L Callahan, Julia W Y Kam","doi":"10.1177/10870547251394173","DOIUrl":"10.1177/10870547251394173","url":null,"abstract":"<p><strong>Background: </strong>ADHD has been characterised by excessive mind wandering (MW), or thoughts unrelated to the task at hand, with recent findings indicating that ADHD is specifically associated with more unintentional, but not intentional, MW. These two types of MW are also differentially associated with affective well-being. Most existing studies in ADHD, however, mainly rely on retrospective reports of MW tendencies, which are susceptible to memory-related errors and biases. Further, most studies categorise participants based on overall levels of ADHD, instead of accounting for the spectrum and dimensional heterogeneity of ADHD, including inattention and hyperactivity symptom dimensions. Our study aimed to address the knowledge gap regarding the relationship between different types of MW and affective well-being, across different symptom dimensions of ADHD.</p><p><strong>Methods: </strong>We used ecological momentary assessment to capture participants' momentary attention state (on-task, intentional MW, or unintentional MW) and affective valence, six times daily for 7 days. Using linear mixed-effects modelling to account for inter-individual variance, we tested whether inattention and hyperactivity symptom dimensions of ADHD differentially moderate the relationship between attention states and affective valence.</p><p><strong>Results: </strong>We found that higher levels of inattention symptoms predicted more negative affect during intentional MW compared to on-task attention; in contrast, higher levels of hyperactivity symptoms predicted more positive affect during intentional MW compared to on-task attention.</p><p><strong>Discussion: </strong>Together, our results indicate that intentional MW moderates opposing effects of inattention and hyperactivity ADHD symptoms on affective valence. Our findings suggest that intentional MW - and not just unintentional MW - may also play a role in affective or behavioural outcomes associated with ADHD symptomatology, and highlight the importance of considering the heterogeneity of ADHD symptomatology, as well as the distinction between intentional and unintentional MW, in future ADHD research.</p>","PeriodicalId":15237,"journal":{"name":"Journal of Attention Disorders","volume":" ","pages":"249-264"},"PeriodicalIF":2.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12779771/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145762729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01Epub Date: 2025-10-16DOI: 10.1177/10870547251382679
Brian T Wymbs, Christie T Pickel, Steven W Evans, Peggy M Zoccola, Ryan C Shorey, Levi M Toback
Objective: Attention-deficit/hyperactivity disorder (ADHD) has been shown to increase the risk of young adults perpetrating and being victims of intimate partner violence (IPV). However, research has yet to examine the IPV experiences of both dyad members where one or both partners has ADHD, and how those experiences differ from couples including partners without ADHD.
Methods: 41 "ADHD couples" (m age = 22.7 years), where one (n = 33) or both (n = 8) dyad members had ADHD, and 28 "Non-ADHD couples" (m age = 23.4 years), where both dyad members did not have ADHD, participated. Both partners reported on the frequency they perpetrated and were victims of psychological and physical IPV.
Results: Both partners in ADHD couples reported perpetrating more psychological and physical IPV than dyad members in Non-ADHD couples. Partners in ADHD couples also reported being victims of IPV more than partners in Non-ADHD couples.
Conclusions: The risk of IPV perpetration in young adult couples with ADHD appears to be a two-way street. Research is needed to examine possible explanations for this pattern of reciprocal IPV, including mutual ADHD symptoms and related behavior (e.g., alcohol intoxication).
{"title":"It Takes Two: Intimate Partner Violence According to Both Partners in Young Adult ADHD Couples.","authors":"Brian T Wymbs, Christie T Pickel, Steven W Evans, Peggy M Zoccola, Ryan C Shorey, Levi M Toback","doi":"10.1177/10870547251382679","DOIUrl":"10.1177/10870547251382679","url":null,"abstract":"<p><strong>Objective: </strong>Attention-deficit/hyperactivity disorder (ADHD) has been shown to increase the risk of young adults perpetrating and being victims of intimate partner violence (IPV). However, research has yet to examine the IPV experiences of both dyad members where one or both partners has ADHD, and how those experiences differ from couples including partners without ADHD.</p><p><strong>Methods: </strong>41 \"ADHD couples\" (<i>m</i> age = 22.7 years), where one (<i>n</i> = 33) or both (<i>n</i> = 8) dyad members had ADHD, and 28 \"Non-ADHD couples\" (<i>m</i> age = 23.4 years), where both dyad members did not have ADHD, participated. Both partners reported on the frequency they perpetrated and were victims of psychological and physical IPV.</p><p><strong>Results: </strong>Both partners in ADHD couples reported perpetrating more psychological and physical IPV than dyad members in Non-ADHD couples. Partners in ADHD couples also reported being victims of IPV more than partners in Non-ADHD couples.</p><p><strong>Conclusions: </strong>The risk of IPV perpetration in young adult couples with ADHD appears to be a two-way street. Research is needed to examine possible explanations for this pattern of reciprocal IPV, including mutual ADHD symptoms and related behavior (e.g., alcohol intoxication).</p>","PeriodicalId":15237,"journal":{"name":"Journal of Attention Disorders","volume":" ","pages":"222-233"},"PeriodicalIF":2.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145300728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}