首页 > 最新文献

Research in Pediatrics & Neonatology最新文献

英文 中文
Food Intolerance and Malabsorption Syndrome in Children: Signs and Symptoms 儿童食物不耐受和吸收不良综合征:体征和症状
Pub Date : 2018-09-07 DOI: 10.31031/RPN.2018.02.000551
T. Yaroshevska
Issues of food intolerance formation in children are currently relevant due to high prevalence and difficulties with diagnostics [1-3]. Environmental pollution can negatively affect quality of food. There are a significant number of food components, which human body is not adapted to during the evolution (e.g. stabilizers, preservatives, transgenic fats, refined products, etc.). Children have anatomical and physiological features that are predisposing to formation of malabsorption syndrome, such as delayed start of digestive enzyme systems, violation of gastrointestinal motility regulation, immaturity of the intestinal microbiocenosis, high intestinal penetration and others.
由于儿童食物不耐受的高患病率和诊断困难,目前与儿童食物不耐受形成问题相关[1-3]。环境污染会对食品质量产生负面影响。有相当数量的食品成分是人体在进化过程中不适应的(如稳定剂、防腐剂、转基因脂肪、精制产品等)。儿童具有易形成吸收不良综合征的解剖和生理特征,如消化酶系统启动延迟、胃肠运动调节紊乱、肠道微生物病发育不成熟、肠道渗透率高等。
{"title":"Food Intolerance and Malabsorption Syndrome in Children: Signs and Symptoms","authors":"T. Yaroshevska","doi":"10.31031/RPN.2018.02.000551","DOIUrl":"https://doi.org/10.31031/RPN.2018.02.000551","url":null,"abstract":"Issues of food intolerance formation in children are currently relevant due to high prevalence and difficulties with diagnostics [1-3]. Environmental pollution can negatively affect quality of food. There are a significant number of food components, which human body is not adapted to during the evolution (e.g. stabilizers, preservatives, transgenic fats, refined products, etc.). Children have anatomical and physiological features that are predisposing to formation of malabsorption syndrome, such as delayed start of digestive enzyme systems, violation of gastrointestinal motility regulation, immaturity of the intestinal microbiocenosis, high intestinal penetration and others.","PeriodicalId":153075,"journal":{"name":"Research in Pediatrics & Neonatology","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132533176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of a Long Term Ventricular Assist Device with a Modified Circuit and Modified Care Model for Short Term Extracorporeal Support: An Institutional Experience 在短期体外支持中使用改良电路和改良护理模式的长期心室辅助装置:一项机构经验
Pub Date : 2018-08-17 DOI: 10.31031/RPN.2018.02.000550
Tanya Chadha, Shamsur Chowdhury, E. Ceithaml, M. Shillingford
The industry of supportive mechanical devices has the pressure of needing to produce products that are reliable, durable, cost effective, and require low maintenance and oversight. In the pediatric population, mechanical support for patients with congenital heart disease is an ongoing challenge. Here we briefly describe our institution’s experience in providing short term extracorporeal support for pediatric congenital heart disease patients through innovative modifications to traditional extracorporeal circuitry and strategies.
辅助机械设备行业面临着需要生产可靠、耐用、成本效益高、维护和监督要求低的产品的压力。在儿科人群中,先天性心脏病患者的机械支持是一个持续的挑战。在此,我们简要介绍我院通过对传统体外电路和策略的创新修改,为儿科先天性心脏病患者提供短期体外支持的经验。
{"title":"Use of a Long Term Ventricular Assist Device with a Modified Circuit and Modified Care Model for Short Term Extracorporeal Support: An Institutional Experience","authors":"Tanya Chadha, Shamsur Chowdhury, E. Ceithaml, M. Shillingford","doi":"10.31031/RPN.2018.02.000550","DOIUrl":"https://doi.org/10.31031/RPN.2018.02.000550","url":null,"abstract":"The industry of supportive mechanical devices has the pressure of needing to produce products that are reliable, durable, cost effective, and require low maintenance and oversight. In the pediatric population, mechanical support for patients with congenital heart disease is an ongoing challenge. Here we briefly describe our institution’s experience in providing short term extracorporeal support for pediatric congenital heart disease patients through innovative modifications to traditional extracorporeal circuitry and strategies.","PeriodicalId":153075,"journal":{"name":"Research in Pediatrics & Neonatology","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133435816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Holoprosencephaly: A Case Study for Communicative and Swallowing Management 无前脑畸形:交流与吞咽治疗的个案研究
Pub Date : 2018-08-13 DOI: 10.31031/RPN.2018.02.000547
M. Ciyiltepe, Z. U. Coskun
Holoprosencephaly (HP) is a developmental central nervous system defect characterized by advanced facial anomalies resulting from the complete separation of two lobes of the cerebral hemispheres [1]. Prevalence is 1.31 in 10,000 births [2,3]. There is a parallel relationship between the combination of different etiological factors in different contributions and the changing clinical picture of the disease. Autosomal dominant and autosomal recessive inherited forms are reported in the literature [4,5]. Considering the studies on holoprosencephaly, developmental, neurological and medical problems were found in children with holoprosencephaly Cohen, 1982; Ersin & Ertugrul, 2005 [6,7]. Table 1 lists the physical findings that can be seen in individuals with HP. Postnatal care of HP is multidisciplinary, symptomatic and long-lasting cognitive and physical supportive therapy. Prognosis depends on the size of the associated medical and neurological disorders (Table 2). Table 1: Physical characteristics that can be seen in
全前脑畸形(holoproencephaly, HP)是一种发育性中枢神经系统缺陷,其特征是大脑半球两个叶完全分离导致晚期面部异常[1]。患病率为万分之1.31[2,3]。不同病因因素的组合在不同的贡献和疾病的临床图像变化之间存在平行关系。常染色体显性和常染色体隐性遗传形式在文献中有报道[4,5]。考虑到对无前脑畸形的研究,在无前脑畸形儿童中发现了发育、神经和医学问题(Cohen, 1982);Ersin & Ertugrul, 2005[6,7]。表1列出了HP患者的身体检查结果。HP的产后护理是多学科、对症和持久的认知和物理支持治疗。预后取决于相关医学和神经系统疾病的大小(表2)
{"title":"Holoprosencephaly: A Case Study for Communicative and Swallowing Management","authors":"M. Ciyiltepe, Z. U. Coskun","doi":"10.31031/RPN.2018.02.000547","DOIUrl":"https://doi.org/10.31031/RPN.2018.02.000547","url":null,"abstract":"Holoprosencephaly (HP) is a developmental central nervous system defect characterized by advanced facial anomalies resulting from the complete separation of two lobes of the cerebral hemispheres [1]. Prevalence is 1.31 in 10,000 births [2,3]. There is a parallel relationship between the combination of different etiological factors in different contributions and the changing clinical picture of the disease. Autosomal dominant and autosomal recessive inherited forms are reported in the literature [4,5]. Considering the studies on holoprosencephaly, developmental, neurological and medical problems were found in children with holoprosencephaly Cohen, 1982; Ersin & Ertugrul, 2005 [6,7]. Table 1 lists the physical findings that can be seen in individuals with HP. Postnatal care of HP is multidisciplinary, symptomatic and long-lasting cognitive and physical supportive therapy. Prognosis depends on the size of the associated medical and neurological disorders (Table 2). Table 1: Physical characteristics that can be seen in","PeriodicalId":153075,"journal":{"name":"Research in Pediatrics & Neonatology","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129311021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Congenital Tuberculosis 先天性结核病
Pub Date : 2018-08-13 DOI: 10.31031/rpn.2018.02.000546
N. Narain
Tuberculosis (TB) is a global public health problem with WHO South-East Asia Region accounting for about 45% of total cases. Tuberculosis is the ninth leading cause of death worldwide and is the leading infectious cause, ranking above HIV/AIDS. In 2016, about 1.3 million HIV negative people died due to tuberculosis [1]. However, Congenital Tuberculosis (CTB) is extremely rare condition with only less than 400 cases being reported thus far [2,3]. As the diagnosis and thus the treatment are often delayed, it has a mortality rate of almost 50% and about 22% in even those who receive treatment [4].
{"title":"Congenital Tuberculosis","authors":"N. Narain","doi":"10.31031/rpn.2018.02.000546","DOIUrl":"https://doi.org/10.31031/rpn.2018.02.000546","url":null,"abstract":"Tuberculosis (TB) is a global public health problem with WHO South-East Asia Region accounting for about 45% of total cases. Tuberculosis is the ninth leading cause of death worldwide and is the leading infectious cause, ranking above HIV/AIDS. In 2016, about 1.3 million HIV negative people died due to tuberculosis [1]. However, Congenital Tuberculosis (CTB) is extremely rare condition with only less than 400 cases being reported thus far [2,3]. As the diagnosis and thus the treatment are often delayed, it has a mortality rate of almost 50% and about 22% in even those who receive treatment [4].","PeriodicalId":153075,"journal":{"name":"Research in Pediatrics & Neonatology","volume":"2012 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125650820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Pyloric Stenosis in Preterm Identical Twins of a Triplet Birth with a Review of Pyloric Stenosis in Premature Neonates 三胞胎早产同卵双胞胎幽门狭窄与早产儿幽门狭窄回顾
Pub Date : 2018-08-13 DOI: 10.31031/RPN.2018.02.000545
Darlene Ac, P. Dd
Pyloric stenosis occurs in 1 of every 200-300 live births and is four times more common in males than in females. Reports of pyloric stenosis in premature neonates are rare. We present a case of pyloric stenosis in premature female identical twins of a triplet birth whose father also had pyloric stenosis. The incidence of pyloric stenosis in premature infants and in identical twins, the age and manner of presentation and the clinical courses of these infants is presented. The potential mode of genetic inheritance is also reviewed.
每200-300例活产婴儿中就有一例幽门狭窄,男性的发生率是女性的四倍。早产儿幽门狭窄的报道是罕见的。我们提出一例幽门狭窄的早产女性同卵双胞胎的三胞胎出生的父亲也有幽门狭窄。本文介绍了早产儿和同卵双胞胎幽门狭窄的发病率、年龄和表现方式以及这些婴儿的临床病程。并对潜在的遗传模式进行了综述。
{"title":"Pyloric Stenosis in Preterm Identical Twins of a Triplet Birth with a Review of Pyloric Stenosis in Premature Neonates","authors":"Darlene Ac, P. Dd","doi":"10.31031/RPN.2018.02.000545","DOIUrl":"https://doi.org/10.31031/RPN.2018.02.000545","url":null,"abstract":"Pyloric stenosis occurs in 1 of every 200-300 live births and is four times more common in males than in females. Reports of pyloric stenosis in premature neonates are rare. We present a case of pyloric stenosis in premature female identical twins of a triplet birth whose father also had pyloric stenosis. The incidence of pyloric stenosis in premature infants and in identical twins, the age and manner of presentation and the clinical courses of these infants is presented. The potential mode of genetic inheritance is also reviewed.","PeriodicalId":153075,"journal":{"name":"Research in Pediatrics & Neonatology","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124534052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Continuous Hand Hygiene Monitoring Associated with a Two-Year Elimination of Central Line Associated Bloodstream Infections in the NICU 连续手卫生监测与两年消除新生儿重症监护病房中心静脉相关血流感染相关
Pub Date : 2018-08-09 DOI: 10.31031/RPN.2018.02.000544
T. Zahouani, Zenaida Reyno, Suraiya Jahan, Lillian Diaz, Melba Talan, Ronald Bainbridge, Y. Sitnitskaya
Hand Hygiene (HH) is the single most important method of preventing Central Line-Associated Bloodstream Infections (CLABSIs). We conducted a continuous 15 months long Performance Improvement project of HH monitoring in the NICU. Overt audit was conducted by trained unit staff, using modified World Health Organization Hand Hygiene Observation Tool. The data collected from October 2015 to December 2016 was entered into a departmental database. Of a total of 1466 observation, HH was observed 591, 40.3% times in nurses, 335, 22.9% times in resident and attending physicians, 148, 10.1% in Respiratory Therapists, and 392, 26.7% times in other ancillary staff. Most observations were conducted during the 0800-1600day shift (768, 52.4%), followed by the 1600-0000 evening shift (358, 24.4%), and then by the 0000-0800night shift (340, 23.2%). HH before touching patient was observed most commonly. Overall HH compliance rate increased from the pre-project nadir of 63% to 99.9% during the project period. Only 4 fallouts were identified, all during the day shift. Of these, 3 fallouts were observed in nurses, and 1 in a resident physician. In each instance education was provided in real-time. The interim analysis was shared at monthly unit staff meetings. After the PI project was completed, HH was observed by Head/Charge Nurses and Infection control personnel. From January 2017 to January 2018 HH compliance rate in NICU remained at 100%. There were no CLABSI events for a total of 27 months. Our experience is consistent with previous reports suggesting that education and feedback are the most successful strategies in achieving high HH compliance. We believe that combining real time education with feedback is as important as routine sharing of performance indicators with the multidisciplinary unit team. A positive after-effect in the post PI project phase demonstrates a change in the safety culture of our NICU.
手部卫生(HH)是预防中央静脉相关血流感染(CLABSIs)最重要的方法。我们开展了为期15个月的NICU HH监测绩效改进项目。公开审计由训练有素的单位工作人员使用改良的世界卫生组织手卫生观察工具进行。2015年10月至2016年12月收集的数据被录入部门数据库。在1466例观察中,护士591次,40.3%,住院医师335次,22.9%,呼吸治疗师148次,10.1%,其他辅助人员392次,26.7%。大多数观察是在0800-1600白班进行的(768,52.4%),其次是1600-0000夜班(358,24.4%),然后是0000-0800夜班(340,23.2%)。触碰前HH最为常见。在项目期间,总体HH合规率从项目前的最低水平63%提高到99.9%。只有4个放射性尘埃被确认,都发生在白班。其中,3名护士被观察到,1名住院医师被观察到。在每个实例中,教育都是实时提供的。在每月的单位工作人员会议上分享了中期分析。PI项目完成后,由护士长/主管和感染控制人员对HH进行观察。2017年1月至2018年1月,新生儿重症监护室HH依从率保持在100%。总共27个月没有CLABSI事件。我们的经验与以前的报告一致,表明教育和反馈是实现高卫生合规的最成功的策略。我们认为,将实时教育与反馈相结合,与与多学科单位团队定期分享绩效指标一样重要。PI项目后阶段的积极后续效应表明我们新生儿重症监护室的安全文化发生了变化。
{"title":"Continuous Hand Hygiene Monitoring Associated with a Two-Year Elimination of Central Line Associated Bloodstream Infections in the NICU","authors":"T. Zahouani, Zenaida Reyno, Suraiya Jahan, Lillian Diaz, Melba Talan, Ronald Bainbridge, Y. Sitnitskaya","doi":"10.31031/RPN.2018.02.000544","DOIUrl":"https://doi.org/10.31031/RPN.2018.02.000544","url":null,"abstract":"Hand Hygiene (HH) is the single most important method of preventing Central Line-Associated Bloodstream Infections (CLABSIs). We conducted a continuous 15 months long Performance Improvement project of HH monitoring in the NICU. Overt audit was conducted by trained unit staff, using modified World Health Organization Hand Hygiene Observation Tool. The data collected from October 2015 to December 2016 was entered into a departmental database. Of a total of 1466 observation, HH was observed 591, 40.3% times in nurses, 335, 22.9% times in resident and attending physicians, 148, 10.1% in Respiratory Therapists, and 392, 26.7% times in other ancillary staff. Most observations were conducted during the 0800-1600day shift (768, 52.4%), followed by the 1600-0000 evening shift (358, 24.4%), and then by the 0000-0800night shift (340, 23.2%). HH before touching patient was observed most commonly. Overall HH compliance rate increased from the pre-project nadir of 63% to 99.9% during the project period. Only 4 fallouts were identified, all during the day shift. Of these, 3 fallouts were observed in nurses, and 1 in a resident physician. In each instance education was provided in real-time. The interim analysis was shared at monthly unit staff meetings. After the PI project was completed, HH was observed by Head/Charge Nurses and Infection control personnel. From January 2017 to January 2018 HH compliance rate in NICU remained at 100%. There were no CLABSI events for a total of 27 months. Our experience is consistent with previous reports suggesting that education and feedback are the most successful strategies in achieving high HH compliance. We believe that combining real time education with feedback is as important as routine sharing of performance indicators with the multidisciplinary unit team. A positive after-effect in the post PI project phase demonstrates a change in the safety culture of our NICU.","PeriodicalId":153075,"journal":{"name":"Research in Pediatrics & Neonatology","volume":"86 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122087866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Single Dose Epidural Block for Infra Umbilical Surface Surgery in Children, a Surgeon’s Perspective 单剂量硬膜外阻滞用于儿童脐下表面手术,一个外科医生的观点
Pub Date : 2018-07-19 DOI: 10.31031/rpn.2018.02.000541
V. Gharpure
Choice of anesthetic is a difficult decision considering the many options available these days. Each technique has its unique set of difficulties and complications. Anesthesia technique has to be chosen depending upon type of surgery, condition of patient, duration of surgery, safety, and finally cost. It should be possible to select a technique which provides optimum effect at the least possible cost, without compromising safety at any point.
考虑到目前可供选择的麻醉药很多,选择麻醉药是一个困难的决定。每种技术都有其独特的困难和复杂性。麻醉技术的选择要根据手术类型、病人的情况、手术时间、安全性以及最终的费用来决定。应该有可能选择一种技术,以尽可能低的成本提供最佳效果,而不损害任何一点的安全性。
{"title":"Single Dose Epidural Block for Infra Umbilical Surface Surgery in Children, a Surgeon’s Perspective","authors":"V. Gharpure","doi":"10.31031/rpn.2018.02.000541","DOIUrl":"https://doi.org/10.31031/rpn.2018.02.000541","url":null,"abstract":"Choice of anesthetic is a difficult decision considering the many options available these days. Each technique has its unique set of difficulties and complications. Anesthesia technique has to be chosen depending upon type of surgery, condition of patient, duration of surgery, safety, and finally cost. It should be possible to select a technique which provides optimum effect at the least possible cost, without compromising safety at any point.","PeriodicalId":153075,"journal":{"name":"Research in Pediatrics & Neonatology","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122720283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adolescent Systemic Hypertension: Late Diagnosis of Coarctation of the Aorta 青少年全身性高血压:主动脉缩窄的晚期诊断
Pub Date : 2018-07-16 DOI: 10.31031/RPN.2018.02.000539
M. Giuffre
The morbidity and mortality rates are low for patients undergoing treatment, for both surgical or catheter interventions, though long-term follow-up is required for complications. Today the diagnosis is often made prenatally with the advent of fetal echocardiography; however, approximately 30% of neonates with coarctation remain undiagnosed upon discharge after delivery. This cardiac defect generally results in left ventricular pressure overload and the patient presentation often varies with the severity of the left ventricular outflow tract obstruction. Additionally, coarctation may be associated with other cardiac defects, as well as chromosomal abnormalities such as Turner syndrome. Case Description A 14-year-old boy was referred to our community pediatric cardiology outpatient clinic for an incidental finding of systemic hypertension that was noted by the patient’s family physician on routine evaluation. The patient was completely asymptomatic, with no visual changes, no headaches, and had a normal activity profile by history. He had an unremarkable past medical history and also had a family history of late-onset hypertension. Abstract Coarctation of the aorta accounts for 5–7% of all the cases of congenital heart disease, with an estimated incidence of approximately 3 cases per 10,000 births. Coarctation of the aorta typically presents in the neonatal or early childhood period. The less severe coarctation patients may have subtle clinical findings such as elevated upper limb blood pressure, diminished femoral pulses, and a systolic ejection murmur that often transmits to the back. This case demonstrates that coarctation can be seen in the otherwise healthy adolescent population.
接受手术或导管介入治疗的患者发病率和死亡率较低,但并发症需要长期随访。今天,随着胎儿超声心动图的出现,诊断通常是在产前进行的;然而,大约30%的新生儿在分娩后出院时仍未得到诊断。这种心脏缺陷通常导致左心室压力过载,患者的表现往往随左心室流出道阻塞的严重程度而变化。此外,缩窄可能与其他心脏缺陷以及染色体异常(如特纳综合征)有关。病例描述一个14岁的男孩被转介到我们的社区儿科心脏病门诊,因为他偶然发现全身性高血压,这是由病人的家庭医生在常规评估中注意到的。患者完全无症状,无视觉改变,无头痛,既往活动正常。既往病史一般,有迟发性高血压家族史。主动脉缩窄占所有先天性心脏病病例的5-7%,估计发病率约为每10,000例新生儿中有3例。主动脉缩窄通常出现在新生儿或幼儿期。不太严重的缩窄患者可能有轻微的临床表现,如上肢血压升高,股脉冲减弱,收缩期射血杂音常传播到背部。本病例表明,在其他健康的青少年人群中可以看到缩窄。
{"title":"Adolescent Systemic Hypertension: Late Diagnosis of Coarctation of the Aorta","authors":"M. Giuffre","doi":"10.31031/RPN.2018.02.000539","DOIUrl":"https://doi.org/10.31031/RPN.2018.02.000539","url":null,"abstract":"The morbidity and mortality rates are low for patients undergoing treatment, for both surgical or catheter interventions, though long-term follow-up is required for complications. Today the diagnosis is often made prenatally with the advent of fetal echocardiography; however, approximately 30% of neonates with coarctation remain undiagnosed upon discharge after delivery. This cardiac defect generally results in left ventricular pressure overload and the patient presentation often varies with the severity of the left ventricular outflow tract obstruction. Additionally, coarctation may be associated with other cardiac defects, as well as chromosomal abnormalities such as Turner syndrome. Case Description A 14-year-old boy was referred to our community pediatric cardiology outpatient clinic for an incidental finding of systemic hypertension that was noted by the patient’s family physician on routine evaluation. The patient was completely asymptomatic, with no visual changes, no headaches, and had a normal activity profile by history. He had an unremarkable past medical history and also had a family history of late-onset hypertension. Abstract Coarctation of the aorta accounts for 5–7% of all the cases of congenital heart disease, with an estimated incidence of approximately 3 cases per 10,000 births. Coarctation of the aorta typically presents in the neonatal or early childhood period. The less severe coarctation patients may have subtle clinical findings such as elevated upper limb blood pressure, diminished femoral pulses, and a systolic ejection murmur that often transmits to the back. This case demonstrates that coarctation can be seen in the otherwise healthy adolescent population.","PeriodicalId":153075,"journal":{"name":"Research in Pediatrics & Neonatology","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115302881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of Renin-Angiotensin System Components in Hypertension During Pregnancy 肾素-血管紧张素系统成分在妊娠高血压中的作用
Pub Date : 2018-07-02 DOI: 10.31031/RPN.2018.02.000537
XuanJin Jin
Background: Hypertension is common disease amongst women with pregnancy. It is associated with significant maternal, fetal and infant morbidity. Current research on the mechanism of the hypertensive disorders is limited. The renin-angiotensin system (RAS) is a hormone signaling cascade that regulates blood pressure and systemic electrolyte and fluid balance. Our study was designed to focus on the mechanism of gestational hypertension before preeclampsia occurred, exploring the change in both circulating RAS and local RAS. Methods: The human kidney tissue were collected from patients suffered renal tumor (n: 5) or chronic renal insufficiency (n: 25). The human placental tissues were collected from woman with normal pregnancies (n: 35) and gestational hypertension (n: 21). There is no significant difference in maternal age between normal and gestational hypertension subjects. All the participants received written information, and signed the consent. Results: Before delivery, the circulating PRL and Ang II concentration in the gestational hypertension is significantly lower than that in normal pregnancy. There is no significant difference between gestational hypertension and normal pregnancy after delivery. In the local RAS, AT1, Ang II and Ang 1-7 levels in gestational hypertension placenta were significantly higher than normal pregnancy. There is no statistical difference of renin, AGT, and ACE, ACE2 between the two subjects. Conclusion: The change of Ang (1-7) expression in our study is different from the previous studies in preeclampsia. More attention should be put on the balance of Ang II and Ang (1-7).
背景:高血压是妊娠妇女的常见病。它与显著的母体、胎儿和婴儿发病率相关。目前对高血压病发病机制的研究比较有限。肾素-血管紧张素系统(RAS)是一种激素信号级联,调节血压和全身电解质和液体平衡。本研究旨在探讨子痫前期妊娠高血压的发生机制,探讨循环RAS和局部RAS的变化。方法:取肾肿瘤患者(5例)和慢性肾功能不全患者(25例)的人体肾组织。取正常妊娠(35例)和妊娠期高血压(21例)妇女的胎盘组织。正常和妊娠期高血压患者的产妇年龄无显著差异。所有参与者都收到了书面信息,并签署了同意书。结果:妊娠期高血压患者产前循环PRL、Ang浓度明显低于正常妊娠。妊娠期高血压与分娩后正常妊娠无显著差异。妊娠期高血压胎盘局部RAS、AT1、Ang II、Ang 1-7水平明显高于正常妊娠。肾素、AGT、ACE、ACE2在两组间比较无统计学差异。结论:本研究中Ang(1-7)的表达变化与前人在子痫前期的研究不同。应更多地关注Ang II和Ang(1-7)的平衡。
{"title":"Role of Renin-Angiotensin System Components in Hypertension During Pregnancy","authors":"XuanJin Jin","doi":"10.31031/RPN.2018.02.000537","DOIUrl":"https://doi.org/10.31031/RPN.2018.02.000537","url":null,"abstract":"Background: Hypertension is common disease amongst women with pregnancy. It is associated with significant maternal, fetal and infant morbidity. Current research on the mechanism of the hypertensive disorders is limited. The renin-angiotensin system (RAS) is a hormone signaling cascade that regulates blood pressure and systemic electrolyte and fluid balance. Our study was designed to focus on the mechanism of gestational hypertension before preeclampsia occurred, exploring the change in both circulating RAS and local RAS. Methods: The human kidney tissue were collected from patients suffered renal tumor (n: 5) or chronic renal insufficiency (n: 25). The human placental tissues were collected from woman with normal pregnancies (n: 35) and gestational hypertension (n: 21). There is no significant difference in maternal age between normal and gestational hypertension subjects. All the participants received written information, and signed the consent. Results: Before delivery, the circulating PRL and Ang II concentration in the gestational hypertension is significantly lower than that in normal pregnancy. There is no significant difference between gestational hypertension and normal pregnancy after delivery. In the local RAS, AT1, Ang II and Ang 1-7 levels in gestational hypertension placenta were significantly higher than normal pregnancy. There is no statistical difference of renin, AGT, and ACE, ACE2 between the two subjects. Conclusion: The change of Ang (1-7) expression in our study is different from the previous studies in preeclampsia. More attention should be put on the balance of Ang II and Ang (1-7).","PeriodicalId":153075,"journal":{"name":"Research in Pediatrics & Neonatology","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131276237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Childhood Gastric Teratoma: A Case Report 儿童胃畸胎瘤1例报告
Pub Date : 2018-06-11 DOI: 10.31031/rpn.2018.02.000535
P. Halder, K. Mandal, A. Das, B. Debnath
Gastric teratoma is relatively rare type of extra gonadal germ cell tumor which comprises <1% of all teratomas. It usually presents with abdominal mass and features of gastric outlet obstruction with or without gastrointestinal bleeding. Complete excision of the tumor is the best mode of treatment. Here, we report a case of gastric teratoma in a two month old male child where we had to go for partial gastrectomy owing to complete removal of the tumor.
胃畸胎瘤是一种较为罕见的性腺外生殖细胞肿瘤,占所有畸胎瘤的不到1%。它通常以腹部肿块和胃出口梗阻为特征,伴有或不伴有胃肠道出血。完全切除肿瘤是最好的治疗方式。在此,我们报告一个两个月大的男婴胃畸胎瘤病例,由于肿瘤完全切除,我们不得不进行部分胃切除术。
{"title":"Childhood Gastric Teratoma: A Case Report","authors":"P. Halder, K. Mandal, A. Das, B. Debnath","doi":"10.31031/rpn.2018.02.000535","DOIUrl":"https://doi.org/10.31031/rpn.2018.02.000535","url":null,"abstract":"Gastric teratoma is relatively rare type of extra gonadal germ cell tumor which comprises <1% of all teratomas. It usually presents with abdominal mass and features of gastric outlet obstruction with or without gastrointestinal bleeding. Complete excision of the tumor is the best mode of treatment. Here, we report a case of gastric teratoma in a two month old male child where we had to go for partial gastrectomy owing to complete removal of the tumor.","PeriodicalId":153075,"journal":{"name":"Research in Pediatrics & Neonatology","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115832571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
期刊
Research in Pediatrics & Neonatology
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1