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Neuroprotection with hypothermic reperfusion and extracorporeal cardiopulmonary resuscitation - A randomized controlled animal trial of prolonged ventricular fibrillation cardiac arrest in rats. 低体温再灌注和体外心肺复苏对神经的保护--对大鼠长时间心室颤动心脏骤停的随机对照动物试验。
IF 4.9 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-09-09 DOI: 10.1177/0271678X241281485
Ingrid Magnet, Alexandra-Maria Stommel, Christoph Schriefl, Matthias Mueller, Michael Poppe, Juergen Grafeneder, Christoph Testori, Andreas Janata, Andreas Schober, Daniel Grassmann, Wilhelm Behringer, Wolfgang Weihs, Michael Holzer, Sandra Hoegler, Florian Ettl

Extracorporeal cardiopulmonary resuscitation (ECPR) facilitates resuscitation with immediate and precise temperature control. This study aimed to determine the optimal reperfusion temperature to minimize neurological damage after ventricular fibrillation cardiac arrest (VFCA). Twenty-four rats were randomized (n = 8 per group) to normothermia (NT = 37°C), mild hypothermia (MH = 33°C) or moderate hypothermia (MOD = 27°C). The rats were subjected to 10 minutes of VFCA, before 15 minutes of ECPR at their respective target temperature. After ECPR weaning, rats in the MOD group were rapidly rewarmed to 33°C, and temperature maintained at 33°C (MH/MOD) or 37°C (NT) for 12 hours before slow rewarming to normothermia (MH/MOD). The primary outcome was 30-day survival with overall performance category (OPC) 1 or 2 (1 = normal, 2 = slight disability, 3 = severe disability, 4 = comatose, 5 = dead). Secondary outcomes included awakening rate (OPC ≤ 3) and neurological deficit score (NDS, from 0 = normal to 100 = brain dead). The survival rate did not differ between reperfusion temperatures (NT = 25%, MH = 63%, MOD = 38%, p = 0.301). MH had the lowest NDS (NT = 4[IQR 3-4], MH = 2[1-2], MOD = 5[3-5], p = 0.044) and highest awakening rate (NT = 25%, MH = 88%, MOD = 75%, p = 0.024). In conclusion, ECPR with 33°C reperfusion did not statistically significantly improve survival after VFCA when compared with 37°C or 27°C reperfusion but was neuroprotective as measured by awakening rate and neurological function.

体外心肺复苏(ECPR)可通过即时、精确的温度控制促进复苏。本研究旨在确定室颤性心脏骤停(VFCA)后减少神经损伤的最佳再灌注温度。24 只大鼠被随机分为常温(NT = 37°C)、轻度低体温(MH = 33°C)或中度低体温(MOD = 27°C)三组(每组 8 只)。对大鼠进行 10 分钟的 VFCA,然后在各自的目标温度下进行 15 分钟的 ECPR。ECPR 断流后,MOD 组大鼠被迅速复温至 33°C,并在 33°C (MH/MOD)或 37°C (NT)的温度下维持 12 小时,然后缓慢复温至正常体温(MH/MOD)。主要结果是总体表现类别(OPC)为1或2(1=正常,2=轻度残疾,3=重度残疾,4=昏迷,5=死亡)的30天存活率。次要结果包括苏醒率(OPC ≤ 3)和神经功能缺损评分(NDS,从 0 = 正常到 100 = 脑死亡)。不同再灌注温度下的存活率没有差异(NT = 25%,MH = 63%,MOD = 38%,P = 0.301)。MH的NDS最低(NT = 4[IQR 3-4],MH = 2[1-2],MOD = 5[3-5],P = 0.044),苏醒率最高(NT = 25%,MH = 88%,MOD = 75%,P = 0.024)。总之,与 37°C 或 27°C 再灌注相比,33°C 再灌注 ECPR 在统计学上并不能显著提高 VFCA 后的存活率,但从苏醒率和神经功能角度来看,它具有神经保护作用。
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引用次数: 0
Increased peripheral leukocyte aggravates brain injury and leads to poor outcome in stroke patients receiving intravenous thrombolysis: A study based on clinical evidence. 外周血白细胞增加加重脑损伤,导致接受静脉溶栓治疗的中风患者预后不佳:基于临床证据的研究。
IF 4.9 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-09-05 DOI: 10.1177/0271678X241281020
Ke-Jia Zhang, Yang Qu, Reziya Abuduxukuer, Peng Zhang, Yu Zhang, Jian-Hua Gao, Xian-Kun Zhang, Xiao-Dong Liu, Chun-Ying Li, Guang-Cai Li, Jun-Min Wang, Hui-Min Jin, Ying He, Li-Gang Jiang, Liang Liu, Yongfei Jiang, Rui-Hong Teng, Yan Jia, Bai-Jing Zhang, Zhi-Bo Chen, Yingbin Qi, Xiu-Ping Liu, Song Li, Thanh N Nguyen, Yi Yang, Zhen-Ni Guo

Whether the dynamic development of peripheral inflammation aggravates brain injury and leads to poor outcome in stroke patients receiving intravenous thrombolysis (IVT), remains unclear and warrants further study. In this study, total of 1034 patients with acute ischemic stroke who underwent IVT were enrolled. Serum leukocyte variation (whether increase from baseline to 24 h after IVT), National Institutes of Health Stroke Scale (NIHSS), infarct volume, early neurologic deterioration (END), the unfavorable outcome at 3-month (modified Rankin Scale [mRS] score ≥3) and mortality were recorded. Serum brain injury biomarkers, including Glial fibrillary acidic protein (GFAP), ubiquitin c-terminal hydrolase L1 (UCH-L1), S100β, neuron-specific enolase (NSE), were measured to reflect the extent of brain injury. We found that patients with increased serum leukocytes had elevated brain injury biomarkers (GFAP, UCH-L1, and S100β), larger infarct volume, higher 24 h NIHSS, higher proportion of END, unfavorable outcome and mortality. Furthermore, an increase in serum leukocytes was independently associated with infarct volume, 24 h NIHSS, END, and unfavorable outcome at 3 months, and serum UCH-L1, S100β, and NSE levels. These results suggest that an increase in serum leukocytes indicates severe brain injury and may be used to predict the outcome of patients with ischemic stroke who undergo IVT.

外周炎症的动态发展是否会加重脑损伤并导致接受静脉溶栓(IVT)的脑卒中患者预后不佳,目前仍不清楚,需要进一步研究。本研究共纳入了 1034 名接受静脉溶栓治疗的急性缺血性脑卒中患者。研究记录了血清白细胞的变化(从基线到静脉溶栓后24小时是否增加)、美国国立卫生研究院卒中量表(NIHSS)、梗死体积、早期神经功能恶化(END)、3个月时的不良预后(改良Rankin量表[mRS]评分≥3)和死亡率。测量血清脑损伤生物标志物,包括胶质纤维酸性蛋白(GFAP)、泛素 c 端水解酶 L1(UCH-L1)、S100β、神经元特异性烯醇化酶(NSE),以反映脑损伤的程度。我们发现,血清白细胞增高的患者脑损伤生物标志物(GFAP、UCH-L1 和 S100β)升高,梗死体积增大,24 h NIHSS 增高,END 比例增高,预后不良,死亡率增高。此外,血清白细胞的增加与梗死容积、24 h NIHSS、END、3 个月时的不良预后以及血清 UCH-L1、S100β 和 NSE 水平均有独立相关性。这些结果表明,血清白细胞的增加预示着严重的脑损伤,可用于预测接受 IVT 的缺血性脑卒中患者的预后。
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引用次数: 0
Estimation of cerebrovascular reactivity amplitude and lag using breath-holding fMRI and the global BOLD signal: Application in diabetes and hypertension. 利用屏气 fMRI 和全局 BOLD 信号估算脑血管反应幅度和滞后:在糖尿病和高血压中的应用。
IF 4.9 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-09-03 DOI: 10.1177/0271678X241270420
Nuwan D Nanayakkara, Liesel-Ann Meusel, Nicole D Anderson, J Jean Chen

In this work, we demonstrate a data-driven approach for estimating cerebrovascular reactivity (CVR) amplitude and lag from breathhold (BH) fMRI data alone. Our approach employs a frequency-domain approach that is independent of external recordings. CVR amplitude is estimated from the BOLD frequency spectrum and CVR lag is estimated from the Fourier phase using the global-mean BOLD signal as reference. Unlike referencing to external recordings, these lags are specific to the brain. We demonstrated our method in detecting regional CVR amplitude and lag differences across healthy (CTL), hypertensive (HT) and hypertension-plus-type-2-diabetes (HT + DM) groups of similar ages and sex ratios, with a total N of 49. We found CVR amplitude to be significantly higher in CTL compared to HT + DM, with minimal difference between CTL and HT. Also, voxelwise CVR lag estimated in the Fourier domain is a more sensitive marker of vascular dysfunction than CVR amplitude. CVR lag in HT is significantly shorter than in CTL, with minimal difference between CTL and HT + DM. Our results support the importance of joint CVR amplitude and lag assessments in clinical applications.

在这项工作中,我们展示了一种数据驱动的方法,可以仅通过屏气(BH)fMRI 数据估计脑血管反应性(CVR)的振幅和滞后。我们的方法采用独立于外部记录的频域方法。CVR 幅值根据 BOLD 频谱估算,而 CVR 滞后则以全局平均 BOLD 信号为参考,根据傅里叶相位估算。与参考外部记录不同,这些滞后是大脑特有的。我们在检测健康组(CTL)、高血压组(HT)和高血压加 2 型糖尿病组(HT + DM)的区域 CVR 振幅和滞后差异时展示了我们的方法。我们发现 CTL 组的 CVR 振幅明显高于 HT + DM 组,而 CTL 组与 HT 组之间的差异很小。此外,与 CVR 波幅相比,在傅立叶域估算的体素 CVR 滞后是血管功能障碍的更敏感标志。HT 的 CVR 滞后明显短于 CTL,而 CTL 和 HT + DM 之间的差异极小。我们的研究结果证明了联合评估 CVR 振幅和滞后在临床应用中的重要性。
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引用次数: 0
Serotonergic regulation of cortical neurovascular coupling and hemodynamics upon awakening from sleep in mice. 小鼠从睡眠中苏醒后大脑皮层神经血管耦合和血液动力学的血清素能调节。
IF 4.9 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-09-01 Epub Date: 2024-03-13 DOI: 10.1177/0271678X241238843
Akiyo Natsubori, Soojin Kwon, Yoshiko Honda, Takashi Kojima, Akihiro Karashima, Kazuto Masamoto, Makoto Honda

Neurovascular coupling (NVC) is the functional hyperemia of the brain responding to local neuronal activity. It is mediated by astrocytes and affected by subcortical ascending pathways in the cortex that convey information, such as sensory stimuli and the animal condition. Here, we investigate the influence of the raphe serotonergic system, a subcortical ascending arousal system in animals, on the modulation of cortical NVC and cerebral blood flow (CBF). Raphe serotonergic neurons were optogenically activated for 30 s, which immediately awakened the mice from non-rapid eye movement sleep. This caused a biphasic cortical hemodynamic change: a transient increase for a few seconds immediately after photostimulation onset, followed by a large progressive decrease during the stimulation period. Serotonergic neuron activation increased intracellular Ca2+ levels in cortical pyramidal neurons and astrocytes, demonstrating its effect on the NVC components. Pharmacological inhibition of cortical neuronal firing activity and astrocyte metabolic activity had small hypovolemic effects on serotonin-induced biphasic CBF changes, while blocking 5-HT1B receptors expressed primarily in cerebral vasculature attenuated the decreasing CBF phase. This suggests that serotonergic neuron activation leading to animal awakening could allow the NVC to exert a hyperemic function during a biphasic CBF response, with a predominant decrease in the cortex.

神经血管耦合(NVC)是大脑对局部神经元活动做出反应的功能性充血。它由星形胶质细胞介导,并受到皮层下上升通路的影响,而皮层下上升通路传递的信息包括感官刺激和动物状态。在此,我们研究了动物皮层下上升唤醒系统--剑突五羟色胺能系统对皮层 NVC 和脑血流(CBF)调节的影响。光源激活斜方肌5-羟色胺能神经元30秒,可立即将小鼠从非快速眼动睡眠中唤醒。这引起了大脑皮层血液动力学的双相变化:光刺激开始后的几秒钟内出现瞬时增加,随后在刺激期间出现大量的渐进性减少。羟色胺能神经元的激活增加了皮质锥体神经元和星形胶质细胞的细胞内 Ca2+ 水平,证明了它对 NVC 成分的影响。药物抑制大脑皮层神经元的发射活动和星形胶质细胞的代谢活动对血清素诱导的双相 CBF 变化有较小的低血容量作用,而阻断主要在脑血管中表达的 5-HT1B 受体可减轻 CBF 下降阶段。这表明,导致动物苏醒的血清素能神经元激活可使 NVC 在双相 CBF 反应期间发挥充血功能,而皮层则主要出现下降。
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引用次数: 0
The effectiveness and safety of human urinary kallidinogenase in acute ischemic stroke patients undergoing endovascular therapy. 接受血管内治疗的急性缺血性脑卒中患者服用人尿液凯利苷原酶的有效性和安全性。
IF 4.9 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-09-01 Epub Date: 2024-03-09 DOI: 10.1177/0271678X241238033
Mengmeng Wang, Changwei Guo, Jie Yang, Jing Li, Jinrong Hu, Zhouzhou Peng, Meng Guo, Lingyu Zhang, Fengli Li, Qingwu Yang, Wenjie Zi, Pengfei Wang

The effectiveness and safety of human urinary kallidinogenase (HUK) in acute ischemic stroke (AIS) patients undergoing endovascular therapy (EVT) due to large vessel occlusion (LVO) was unclear. A pooled analysis was performed using individual data from the DEVT and RESCUE BT trials. Patients were divided into two groups based on HUK treatment. The primary outcome was the 90-day modified Rankin Scale (mRS) score. Safety outcomes included 90-day mortality and symptomatic intracranial hemorrhage (sICH) within 48 hours. A total of 1174 patients were included in the study. Of these, 150 (12.8%) patients received HUK. The adjusted common odds ratio (OR) of the mRS score was 1.458 (95% confidence interval [CI] = 1.072-1.983; p = 0.016) favoring HUK. The incidence of sICH (2.0% vs. 8.6%; adjusted OR: 0.198; 95% CI: 0.061-0.638; p = 0.007) and mortality (11.3% vs.18.5%; adjusted OR: 0.496; 95% CI: 0.286-0.862; p = 0.013) was lower in HUK group than non-HUK group. This association was consistent with propensity score-matching and the inverse probability of treatment weighting analysis. In conclusion, HUK was safe and associated with a preferable prognosis in AIS patients due to LVO in the anterior circulation.

对于因大血管闭塞(LVO)而接受血管内治疗(EVT)的急性缺血性卒中(AIS)患者,人尿凯利苷原酶(HUK)的有效性和安全性尚不明确。我们利用 DEVT 和 RESCUE BT 试验的个别数据进行了汇总分析。根据 HUK 治疗将患者分为两组。主要结果是 90 天改良 Rankin 量表(mRS)评分。安全性结果包括90天死亡率和48小时内无症状性颅内出血(sICH)。研究共纳入了 1174 名患者。其中 150 例(12.8%)患者接受了 HUK 治疗。调整后的 mRS 评分共同几率比 (OR) 为 1.458(95% 置信区间 [CI] = 1.072-1.983;P = 0.016),HUK 更受青睐。HUK 组的 sICH 发生率(2.0% 对 8.6%;调整 OR:0.198;95% CI:0.061-0.638;p = 0.007)和死亡率(11.3% 对 18.5%;调整 OR:0.496;95% CI:0.286-0.862;p = 0.013)均低于非 HUK 组。这种关联与倾向评分匹配和治疗加权逆概率分析结果一致。总之,对于因前循环低左室血流阻塞而导致的 AIS 患者,HUK 是安全的,且预后较好。
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引用次数: 0
Macro- and microvascular contributions to cerebral structural alterations in patients with asymptomatic carotid artery stenosis. 大血管和微血管对无症状颈动脉狭窄患者脑结构改变的影响。
IF 4.9 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-09-01 Epub Date: 2024-03-20 DOI: 10.1177/0271678X241238935
Lena Schmitzer, Stephan Kaczmarz, Jens Göttler, Gabriel Hoffmann, Michael Kallmayer, Hans-Henning Eckstein, Dennis Martin Hedderich, Jan Kufer, Claus Zimmer, Christine Preibisch, Fahmeed Hyder, Nico Sollmann

Atherosclerosis can underly internal carotid artery stenosis (ICAS), a major risk factor for ischemic stroke, as well as small vessel disease (SVD). This study aimed to investigate hemodynamics and structural alterations associated with SVD in ICAS patients. 28 patients with unilateral asymptomatic ICAS and 30 age-matched controls underwent structural (T1-/T2-weighted and diffusion tensor imaging [DTI]) and hemodynamic (pseudo-continuous arterial spin labeling and dynamic susceptibility contrast) magnetic resonance imaging. SVD-related alterations were assessed using free water (FW), FW-corrected DTI, and peak-width of skeletonized mean diffusivity (PSMD). Furthermore, cortical thickness, cerebral blood flow (CBF), and capillary transit time heterogeneity (CTH) were analyzed. Ipsilateral to the stenosis, cortical thickness was significantly decreased in the posterior dorsal cingulate cortex (p = 0.024) and temporal pole (p = 0.028). ICAS patients exhibited elevated PSMD (p = 0.005), FW (p < 0.001), and contralateral alterations in FW-corrected DTI metrics. We found significantly lateralized CBF (p = 0.011) and a tendency for lateralized CTH (p = 0.067) in the white matter (WM) related to ICAS. Elevated PSMD and FW may indicate a link between SVD and WM changes. Contralateral alterations were seen in FW-corrected DTI, whereas hemodynamic and cortical changes were mainly ipsilateral, suggesting SVD might influence global brain changes concurrent with ICAS-related hemodynamic alterations.

颈内动脉狭窄(ICAS)和小血管疾病(SVD)是缺血性脑卒中的主要危险因素,而动脉粥样硬化是颈内动脉狭窄的基础。本研究旨在调查与ICAS患者SVD相关的血液动力学和结构改变。28名单侧无症状ICAS患者和30名年龄匹配的对照组患者接受了结构(T1-/T2-加权和弥散张量成像[DTI])和血液动力学(假连续动脉自旋标记和动态感性对比)磁共振成像检查。利用自由水(FW)、FW校正DTI和骨架化平均弥散度峰值宽度(PSMD)评估了与SVD相关的改变。此外,还分析了皮质厚度、脑血流量(CBF)和毛细血管转运时间异质性(CTH)。在脑血管狭窄的同侧,后背扣带回皮层(p = 0.024)和颞极(p = 0.028)的皮层厚度明显下降。ICAS 患者表现出 PSMD(p = 0.005)、FW(p
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引用次数: 0
Cpeb4-mediated Dclk2 promotes neuronal pyroptosis induced by chronic cerebral ischemia through phosphorylation of Ehf. Cpeb4介导的Dclk2通过磷酸化Ehf促进慢性脑缺血诱导的神经元热解。
IF 4.9 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-09-01 Epub Date: 2024-03-21 DOI: 10.1177/0271678X241240590
Miao Sun, Xin Huang, Xuelei Ruan, Xiuli Shang, Mengyang Zhang, Libo Liu, Ping Wang, Ping An, Yang Lin, Jin Yang, Yixue Xue

Chronic cerebral ischemia (CCI) is a clinical syndrome characterised by brain dysfunction due to decreased chronic cerebral perfusion. CCI initiates several inflammatory pathways, including pyroptosis. RNA-binding proteins (RBPs) play important roles in CCI. This study aimed to explore whether the interaction between RBP-Cpeb4 and Dclk2 affected Ehf phosphorylation to regulate neuronal pyroptosis. HT22 cells and mice were used to construct oxygen glucose deprivation (OGD)/CCI models. We found that Cpeb4 and Dclk2 were upregulated in OGD-treated HT22 cells and CCI-induced hippocampal CA1 tissues. Cpeb4 upregulated Dclk2 expression by increasing Dclk2 mRNA stability. Knockdown of Cpeb4 or Dclk2 inhibited neuronal pyroptosis in OGD-treated HT22 cells and CCI-induced hippocampal CA1 tissues. By binding to the promoter regions of Caspase1 and Caspase3, the transcription factor Ehf reduced their promoter activities and inhibited the transcription. Dclk2 phosphorylated Ehf and changed its nucleoplasmic distribution, resulting in the exit of p-Ehf from the nucleus and decreased Ehf levels. It promoted the expression of Caspase1 and Caspase3 and stimulated neuronal pyroptosis of HT22 cells induced by OGD. Cpeb4/Dclk2/Ehf pathway plays an important role in the regulation of cerebral ischemia-induced neuronal pyroptosis.

慢性脑缺血(CCI)是一种临床综合征,其特点是慢性脑灌注减少导致脑功能障碍。慢性脑缺血会引发多种炎症通路,包括脓毒症。RNA结合蛋白(RBPs)在CCI中发挥着重要作用。本研究旨在探讨RBP-Cpeb4和Dclk2之间的相互作用是否会影响Ehf磷酸化,从而调控神经元的热昏迷。研究利用 HT22 细胞和小鼠构建了氧葡萄糖剥夺(OGD)/CCI 模型。我们发现,Cpeb4和Dclk2在OGD处理的HT22细胞和CCI诱导的海马CA1组织中上调。Cpeb4通过增加Dclk2 mRNA的稳定性上调Dclk2的表达。敲除Cpeb4或Dclk2可抑制OGD处理的HT22细胞和CCI诱导的海马CA1组织中神经元的热凋亡。转录因子Ehf通过与Caspase1和Caspase3的启动子区域结合,降低了它们的启动子活性,抑制了它们的转录。Dclk2使Ehf磷酸化,改变了其在核质中的分布,导致p-Ehf从细胞核中退出,Ehf水平下降。它促进了 Caspase1 和 Caspase3 的表达,并刺激了 OGD 诱导的 HT22 细胞的神经元凋亡。Cpeb4/Dclk2/Ehf通路在调控脑缺血诱导的神经元凋亡中发挥了重要作用。
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引用次数: 0
Early and enduring: Targeting the endothelium for blood-brain barrier protection. 早期和持久:以内皮为目标,保护血脑屏障。
IF 4.9 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-09-01 Epub Date: 2024-06-21 DOI: 10.1177/0271678X241264086
Silin Wu, Xuefang Sophie Ren, Yejie Shi

The disruption of the blood-brain barrier marks a pivotal early pathological event in ischemic stroke that significantly contributes to subsequent permanent damage. Here we delve into the ramifications of a study conducted by Xu and colleagues, which underscores the essential role of the protein peroxiredoxin-4 in cerebrovascular endothelial cells. Peroxiredoxin-4 was shown to preserve blood-brain barrier integrity during the early stages after cerebral ischemia and reperfusion, ultimately leading to improved long-term outcomes.

血脑屏障的破坏是缺血性中风的一个关键性早期病理事件,对随后的永久性损伤起着重要作用。徐及其同事的研究强调了过氧化物歧化酶-4 蛋白在脑血管内皮细胞中的重要作用。研究表明,过氧化物歧化酶-4 能在脑缺血和再灌注后的早期阶段保护血脑屏障的完整性,最终改善长期预后。
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引用次数: 0
Metabolic coupling between glutamate and N-acetylaspartate in the human brain. 人脑中谷氨酸和 N-乙酰天冬氨酸之间的代谢耦合。
IF 4.9 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-09-01 Epub Date: 2024-03-14 DOI: 10.1177/0271678X241239783
Sungtak Hong, Jyoti Singh Tomar, Jun Shen

A metabolic coupling between glutamate and N-acetylaspartate measured by in vivo magnetic resonance spectroscopy has been recently reported in the literature with inconsistent findings. In this study, confounders originating from Pearson's spurious correlation of ratios and spectral correlation due to overlapping magnetic resonance spectroscopy signals of glutamate and N-acetylaspartate were practically eliminated to facilitate the determination of any metabolic link between glutamate and N-acetylaspartate in the human brain using in vivo magnetic resonance spectroscopy. In both occipital and medial prefrontal cortices of healthy individuals, correlations between glutamate and N-acetylaspartate were found to be insignificant. Our results do not lend support to a recent hypothesis that N-acetylaspartate serves as a significant reservoir for the rapid replenishment of glutamate during signaling or stress.

最近有文献报道通过体内磁共振波谱测量谷氨酸和 N-乙酰天冬氨酸之间的代谢耦合,但结果并不一致。在这项研究中,为了便于利用体内磁共振波谱测定人脑中谷氨酸和 N-乙酰天冬氨酸之间的代谢联系,研究人员实际上消除了由于谷氨酸和 N-乙酰天冬氨酸的磁共振波谱信号重叠而产生的皮尔逊比率假相关性和光谱相关性所造成的混淆因素。在健康人的枕叶和内侧前额叶皮层中,谷氨酸和 N-乙酰天冬氨酸之间的相关性并不显著。我们的研究结果并不支持最近提出的一种假说,即 N-乙酰天冬氨酸是谷氨酸在信号传导或压力期间快速补充的重要储存库。
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引用次数: 0
Quantification of brain-wide vascular resistivity via ultrafast Doppler in human neonates helps early detection of white matter injury. 通过超快多普勒对人类新生儿全脑血管电阻率进行量化,有助于早期检测白质损伤。
IF 4.9 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-09-01 Epub Date: 2024-02-10 DOI: 10.1177/0271678X241232197
Flora Faure, Jérôme Baranger, Marianne Alison, Béatrice Boutillier, Alice Frérot, Chung Lim, Grégory Planchette, Mickael Prigent, Mickaël Tanter, Olivier Baud, Valérie Biran, Charlie Demené

Preterm birth is associated with cerebrovascular development disruption and can induce white matter injuries (WMI). Transfontanellar ultrasound Doppler is the most widely used clinical imaging technique to monitor neonatal cerebral vascularisation and haemodynamics based on vascular indexes such as the resistivity index (RI); however, it has poor predictive value for brain damage. Indeed, these RI measurements are currently limited to large vessels, leading to a very limited probing of the brain's vascularisation, which may hinder prognosis. Here we show that ultrafast Doppler imaging (UfD) enables simultaneous quantification, in the whole field of view, of the local RI and vessel diameter, even in small vessels. Combining both pieces of information, we defined two new comprehensive resistivity parameters of the vascular trees. First, we showed that our technique is more sensitive in the early characterisation of the RI modifications between term and preterm neonates and for the first time we could show that the RI depends both on the vessel diameter and vascular territory. We then showed that our parameters can be used for early prediction of WMI. Our results demonstrate the potential of UfD to provide new biomarkers and pave the way for continuous monitoring of neonatal brain resistivity.

早产与脑血管发育障碍有关,并可诱发脑白质损伤(WMI)。根据血管指数(如电阻率指数(RI))监测新生儿脑血管化和血流动力学,经颅骨超声多普勒是最广泛应用的临床成像技术;然而,它对脑损伤的预测价值很低。事实上,这些 RI 测量目前仅限于大血管,导致对脑血管的探测非常有限,这可能会妨碍预后。在这里,我们展示了超快多普勒成像(UfD)能在整个视野中同时量化局部 RI 和血管直径,即使在小血管中也是如此。结合这两项信息,我们定义了血管树的两个新的综合电阻率参数。首先,我们证明了我们的技术在早期鉴定足月和早产新生儿的 RI 变化特征方面更加灵敏,并且首次证明了 RI 同时取决于血管直径和血管区域。随后,我们证明了我们的参数可用于早期预测 WMI。我们的研究结果证明了 UfD 在提供新生物标记物方面的潜力,并为持续监测新生儿脑电阻率铺平了道路。
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Journal of Cerebral Blood Flow and Metabolism
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