Pub Date : 2016-12-05DOI: 10.19070/2332-2977-SI01001
E. S, Lahlou A, Salim G, B. H, Rimani M
Nevoid hyperkeratosis of the nipple and areola (NHNA), first described by Tauber [1] in 1923, is a rare benign condition with fewer than 70 cases reported in the literature. Nevoid hyperkeratosis presents as asymptomatic and hyperpigmented filiform or papular warty excrescences on the nipple, the areola or both. NHNA is commonly bilateral, and appear in women in their second or third decade, at puberty or during pregnancy [2], suggesting the role of hormone in its pathogenesis [1].
乳头乳晕Nevoid hyperkeratosis of nipple and areola (NHNA)，由Tauber[1]于1923年首次描述，是一种罕见的良性疾病，文献报道的病例不到70例。乳突角化过度症表现为无症状和色素沉着的丝状或丘疹状疣状赘生物，在乳头，乳晕或两者。NHNA通常是双侧的，出现在20岁或30岁的女性、青春期或怀孕期间[2]，提示激素在其发病机制中的作用[1]。
{"title":"Unilateral Nevoid Hyperkeratosis of the Nipple and Areola Treated Successfully With Carbon Dioxide Laser","authors":"E. S, Lahlou A, Salim G, B. H, Rimani M","doi":"10.19070/2332-2977-SI01001","DOIUrl":"https://doi.org/10.19070/2332-2977-SI01001","url":null,"abstract":"Nevoid hyperkeratosis of the nipple and areola (NHNA), first described by Tauber [1] in 1923, is a rare benign condition with fewer than 70 cases reported in the literature. Nevoid hyperkeratosis presents as asymptomatic and hyperpigmented filiform or papular warty excrescences on the nipple, the areola or both. NHNA is commonly bilateral, and appear in women in their second or third decade, at puberty or during pregnancy [2], suggesting the role of hormone in its pathogenesis [1].","PeriodicalId":15418,"journal":{"name":"Journal of Clinical Dermatology","volume":"40 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2016-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85554720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-11-19DOI: 10.19070/2332-2977-1600025
Monson Ca, Silva V, Porfírio G, Riera R, Tweed Ja
Psoriasis is defined as an immune-mediated multiple-cause disease of genetic basis [1] and different phenotypes [2] that affects up to 8.5% of the population in the Western countries and requires careful management [3]. Among the skin chronic forms of psoriasis, those with circumscribed thick white to silver plaques, surrounded by areas redness are more common [4]. Psoriasis can spread to the elbows, knees, shins, scalp, lower back, nails, genitals, mouth and joint areas with many grades of damage, leading to the emotional consequences with negative impact in the patient’s life [3, 6]. Oral cavity can reveals details about systemic health status. Oral diseases also have immune-involvement with multiple causes and can lead to local and systemic complications. Oral care are the health treatments that people more often have performed [74]. Relying on surgical resources and increasingly advanced pharmacological therapy, these treatments can lead to the damages, even in healthy patients [4]. In some conditions, dental treatments can be invasive and for Psoriasis it can cause problems in complex ways. The oral aspects for psoriasis were not assessed with a comprehensive literature review and accurate inferences are possible only if a previous systematic analysis of risk factors was done [5].
{"title":"Oral Health Issues in Psoriasis: An Overview of the Literature","authors":"Monson Ca, Silva V, Porfírio G, Riera R, Tweed Ja","doi":"10.19070/2332-2977-1600025","DOIUrl":"https://doi.org/10.19070/2332-2977-1600025","url":null,"abstract":"Psoriasis is defined as an immune-mediated multiple-cause disease of genetic basis [1] and different phenotypes [2] that affects up to 8.5% of the population in the Western countries and requires careful management [3]. Among the skin chronic forms of psoriasis, those with circumscribed thick white to silver plaques, surrounded by areas redness are more common [4]. Psoriasis can spread to the elbows, knees, shins, scalp, lower back, nails, genitals, mouth and joint areas with many grades of damage, leading to the emotional consequences with negative impact in the patient’s life [3, 6]. Oral cavity can reveals details about systemic health status. Oral diseases also have immune-involvement with multiple causes and can lead to local and systemic complications. Oral care are the health treatments that people more often have performed [74]. Relying on surgical resources and increasingly advanced pharmacological therapy, these treatments can lead to the damages, even in healthy patients [4]. In some conditions, dental treatments can be invasive and for Psoriasis it can cause problems in complex ways. The oral aspects for psoriasis were not assessed with a comprehensive literature review and accurate inferences are possible only if a previous systematic analysis of risk factors was done [5].","PeriodicalId":15418,"journal":{"name":"Journal of Clinical Dermatology","volume":"4 1","pages":"94-103"},"PeriodicalIF":0.0,"publicationDate":"2016-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82054837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-10-30DOI: 10.19070/2332-2977-1600023
A. Lahlou, S. Elloudi, H. Baybay, F. Mernissi
Dermatomyositis, a rare inflammatory disease possibly of autoimmune origin, produces a characteristic skin rash and sym - metrical proximal myopathy. Patients with Dermatomyositis have a higher incidence rate of cancer, compared with the general population, since DM usually presents as a paraneoplastic syndrome. through the study of 9 cases of paraneoplastic dermato- myositis we will discuss the clinical feature, paraclinical, etiological, therapeutic and outcomes of paraneoplastic dermatomy- ositis (PDM) relative to the literature.
{"title":"Paraneoplastic Dermatomyositis: About 9 Patients","authors":"A. Lahlou, S. Elloudi, H. Baybay, F. Mernissi","doi":"10.19070/2332-2977-1600023","DOIUrl":"https://doi.org/10.19070/2332-2977-1600023","url":null,"abstract":"Dermatomyositis, a rare inflammatory disease possibly of autoimmune origin, produces a characteristic skin rash and sym - metrical proximal myopathy. Patients with Dermatomyositis have a higher incidence rate of cancer, compared with the general population, since DM usually presents as a paraneoplastic syndrome. through the study of 9 cases of paraneoplastic dermato- myositis we will discuss the clinical feature, paraclinical, etiological, therapeutic and outcomes of paraneoplastic dermatomy- ositis (PDM) relative to the literature.","PeriodicalId":15418,"journal":{"name":"Journal of Clinical Dermatology","volume":"1 1","pages":"87-89"},"PeriodicalIF":0.0,"publicationDate":"2016-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85555257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-10-06DOI: 10.19070/2332-2977-1600024
Lahlou A, E. S, B. H, Mernissi Fz
Primary cutaneous B-cell lymphomas are a heterogeneous group of rare clonal B-cell lymphoproliferative disorders with distinct clinicopathological features compared with nodal counterparts [1]. Primary cutaneous diffuse large B-cell lymphoma-leg type (PCLBCL-LT) is a rare subtype which constitutes only 4% [2]. They have a predilection to the leg (72%), advanced age of onset (mean age, 76 years), high Bcl-2 expression (85%) and frequent relapses with extracutaneous dissemination [10-20%]. We report a case we report the case of a young patient of 39 years old who consulted for a hummocky tumor in the back whose histology was in favor of lymphoma B-type leg, with good response to rituximab combined with doxorubicin, cyclophosphamide, vincristine, and prednison (R-CHOP).
{"title":"Primary Cutaneous Large B Cell Lymphoma, Leg Type: Good Evolution of A Particular Location","authors":"Lahlou A, E. S, B. H, Mernissi Fz","doi":"10.19070/2332-2977-1600024","DOIUrl":"https://doi.org/10.19070/2332-2977-1600024","url":null,"abstract":"Primary cutaneous B-cell lymphomas are a heterogeneous group of rare clonal B-cell lymphoproliferative disorders with distinct clinicopathological features compared with nodal counterparts [1]. Primary cutaneous diffuse large B-cell lymphoma-leg type (PCLBCL-LT) is a rare subtype which constitutes only 4% [2]. They have a predilection to the leg (72%), advanced age of onset (mean age, 76 years), high Bcl-2 expression (85%) and frequent relapses with extracutaneous dissemination [10-20%]. We report a case we report the case of a young patient of 39 years old who consulted for a hummocky tumor in the back whose histology was in favor of lymphoma B-type leg, with good response to rituximab combined with doxorubicin, cyclophosphamide, vincristine, and prednison (R-CHOP).","PeriodicalId":15418,"journal":{"name":"Journal of Clinical Dermatology","volume":"42 1","pages":"90-93"},"PeriodicalIF":0.0,"publicationDate":"2016-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77286976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-05-09DOI: 10.19070/2332-2977-160001
R. Chakiri, Z. Douhi, M. Meziane, Mernissi Fz
Dermatological examination had found: erythematous target lesion in the upper limbs and back (Figure 1), urticarial plaques on the trunk, purpuric lesions on the lower extremities and blisters stretched at the back side of 2 feet and achieving of the buccal and genital mucosa (Figure 2). Admission laboratory tests revealed several abnormal finding: hypereosinophilia in 2100 element/mm3 and hepatic cytolysis (SGOT=92 UI/L→2xN, SGPT=188 UI/L→4xN).
{"title":"Stevens - Johnson Syndrome Induced by Sorafenib for Hepatocellular Carcinoma","authors":"R. Chakiri, Z. Douhi, M. Meziane, Mernissi Fz","doi":"10.19070/2332-2977-160001","DOIUrl":"https://doi.org/10.19070/2332-2977-160001","url":null,"abstract":"Dermatological examination had found: erythematous target lesion in the upper limbs and back (Figure 1), urticarial plaques on the trunk, purpuric lesions on the lower extremities and blisters stretched at the back side of 2 feet and achieving of the buccal and genital mucosa (Figure 2). Admission laboratory tests revealed several abnormal finding: hypereosinophilia in 2100 element/mm3 and hepatic cytolysis (SGOT=92 UI/L→2xN, SGPT=188 UI/L→4xN).","PeriodicalId":15418,"journal":{"name":"Journal of Clinical Dermatology","volume":"99 1","pages":"78-80"},"PeriodicalIF":0.0,"publicationDate":"2016-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84805891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-04-20DOI: 10.19070/2332-2977-160004e
Tapia Fj, Venezuela Ministerio de Salud, R. Ol
{"title":"The Guardians of the Skin Immune System","authors":"Tapia Fj, Venezuela Ministerio de Salud, R. Ol","doi":"10.19070/2332-2977-160004e","DOIUrl":"https://doi.org/10.19070/2332-2977-160004e","url":null,"abstract":"","PeriodicalId":15418,"journal":{"name":"Journal of Clinical Dermatology","volume":"46 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2016-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85982648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-12-02DOI: 10.19070/2332-2977-1500020
P. Morais, L. Peralta, H. Bettencourt, A. Mota
An otherwise healthy 15-year-old female patient presented with multiple bluish skin papules and nodules located at right breast that had been present since birth. The lesions were slightly tender to palpation and had enlarged with body growth, especially after menarche. Her father presented several lesions with a similar appearance on the upper limbs and trunk. On physical examination, multiple soft, well-defined dark-blue and purple-red papules and nodules were observed, arranged in a segmental or band-like pattern, in the girl’s right breast and ipsilateral axilla (Figure 1a). Dermoscopy of lesions revealed reddish purple structureless areas, without specific features of any skin neoplasm (Figure 1b). A biopsy of a breast nodule was performed. The histological examination revealed a non encapsulated vascular tumor involving the mid and lower dermis. It was composed of multiple dilated, cavernous-like capillaries containing erythrocytes surrounded by endothelial cells, and one to several layers of uniform cuboidal cells with pale or faintly eosinophilic cytoplasm (glomus cells) (Figure 1c). These features were consistent with the diagnosis of glomangioma. Complete blood and platelet counts, coagulation tests and fecal occult blood test were within normal range. Informed about the nature of the lesions and treatment options the patient chose therapeutic abstention.
{"title":"Congenital Multiple Glomangiomas of the Breast Arranged in a Segmental Pattern","authors":"P. Morais, L. Peralta, H. Bettencourt, A. Mota","doi":"10.19070/2332-2977-1500020","DOIUrl":"https://doi.org/10.19070/2332-2977-1500020","url":null,"abstract":"An otherwise healthy 15-year-old female patient presented with multiple bluish skin papules and nodules located at right breast that had been present since birth. The lesions were slightly tender to palpation and had enlarged with body growth, especially after menarche. Her father presented several lesions with a similar appearance on the upper limbs and trunk. On physical examination, multiple soft, well-defined dark-blue and purple-red papules and nodules were observed, arranged in a segmental or band-like pattern, in the girl’s right breast and ipsilateral axilla (Figure 1a). Dermoscopy of lesions revealed reddish purple structureless areas, without specific features of any skin neoplasm (Figure 1b). A biopsy of a breast nodule was performed. The histological examination revealed a non encapsulated vascular tumor involving the mid and lower dermis. It was composed of multiple dilated, cavernous-like capillaries containing erythrocytes surrounded by endothelial cells, and one to several layers of uniform cuboidal cells with pale or faintly eosinophilic cytoplasm (glomus cells) (Figure 1c). These features were consistent with the diagnosis of glomangioma. Complete blood and platelet counts, coagulation tests and fecal occult blood test were within normal range. Informed about the nature of the lesions and treatment options the patient chose therapeutic abstention.","PeriodicalId":15418,"journal":{"name":"Journal of Clinical Dermatology","volume":"94 1","pages":"76-77"},"PeriodicalIF":0.0,"publicationDate":"2015-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74973222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-11-13DOI: 10.19070/2332-2977-1500019
S. Swami, Pradhan Ak
Human papillomaviruses (HPVs) under the Papillomavirus family are common agents for producing skin warts in adults; as well as in children, throughout the globe. Although the frequency is unknown, warts are estimated to affect approximately 7-12% of the population. In school-aged children, the prevalence is 10-20%. An increased frequency also is seen among immunosuppressed patients and meat handlers. It is now well known that various HPV types are acquired in early infancy [1] and they persist for a pretty long time in the skin as observed by many scientists-even up to more than 60 years [2-4], and parental sharing of these viruses has also been noted [2, 4], although horizontal transmission from other persons is also an important way to spread this disease [4]. There are more than 200 types, of which 100 has been sequenced. Distinct histopathological types are also attributed to different skin HPVs particularly types 1, 2, 3, 4, 27 and 57 [5]. Verruca vulgaris is the commonest wart, although other types like planter and flat warts are not uncommon. Warts are usually highly prevalent in lower age groups and then gradually decrease with age [6], with no sex preponderance [7]. In a Taiwan study hand warts were found in 2.8 per cent of school children [8]. Warts or Verrucae are of different clinical types, depending on the morphology of the warts, the site affected and the mode of transmission. HPVs affect human skin and the moist membranes such as the throat, mouth, feet, fingers, nails, anus and cervix. It is a self limiting disease and in most of the cases spontaneous resolution takes place within 2yrs. The primary clinical manifestations of HPV infection include common warts, genital warts, flat warts, and deep palmoplantar warts. Most known HPV types cause no symptoms to humans but they may cause cosmetic disfigurement or tenderness. Plantar warts can be painful, and extensive involvement on the sole of the foot may impair ambulation. A small number can increase the risk of cancers specially if the lesion persists for a long time in cervix and vagina, penis, anus and oropharynx (HPV 16 and 18 strains). The CDC observed that over 70 percent of infections in young females clear up within 12 months, while 90% do so within 24 months. There are 40 types of HPVs which are transmitted sexually, affecting ano-genital areas, the other types are transmitted by personal contact or indirect transmission from using untreated swimming pool, fomites etc. or by auto-inoculation. Persistent long-term HPV infection raises the risk of developing precancerous lesions of the cervix and other region. However, in the majority of cases, cancer can be prevented. Among different types, types 16, 18, 33, 35, 45, 51, 52, 56, 58, 59, 68, 73, and 82 can cause cancer they are carcinogenic and are sexually transmitted. The HPV virus enters the human body through a small cut, tear, or abrasion on the epidermis; the primary mode of transmission is through skin-to-skin contact.
{"title":"Rapid Recovery from Skin Warts by Explicit Homeopathic Medicines","authors":"S. Swami, Pradhan Ak","doi":"10.19070/2332-2977-1500019","DOIUrl":"https://doi.org/10.19070/2332-2977-1500019","url":null,"abstract":"Human papillomaviruses (HPVs) under the Papillomavirus family are common agents for producing skin warts in adults; as well as in children, throughout the globe. Although the frequency is unknown, warts are estimated to affect approximately 7-12% of the population. In school-aged children, the prevalence is 10-20%. An increased frequency also is seen among immunosuppressed patients and meat handlers. It is now well known that various HPV types are acquired in early infancy [1] and they persist for a pretty long time in the skin as observed by many scientists-even up to more than 60 years [2-4], and parental sharing of these viruses has also been noted [2, 4], although horizontal transmission from other persons is also an important way to spread this disease [4]. There are more than 200 types, of which 100 has been sequenced. Distinct histopathological types are also attributed to different skin HPVs particularly types 1, 2, 3, 4, 27 and 57 [5]. Verruca vulgaris is the commonest wart, although other types like planter and flat warts are not uncommon. Warts are usually highly prevalent in lower age groups and then gradually decrease with age [6], with no sex preponderance [7]. In a Taiwan study hand warts were found in 2.8 per cent of school children [8]. Warts or Verrucae are of different clinical types, depending on the morphology of the warts, the site affected and the mode of transmission. HPVs affect human skin and the moist membranes such as the throat, mouth, feet, fingers, nails, anus and cervix. It is a self limiting disease and in most of the cases spontaneous resolution takes place within 2yrs. The primary clinical manifestations of HPV infection include common warts, genital warts, flat warts, and deep palmoplantar warts. Most known HPV types cause no symptoms to humans but they may cause cosmetic disfigurement or tenderness. Plantar warts can be painful, and extensive involvement on the sole of the foot may impair ambulation. A small number can increase the risk of cancers specially if the lesion persists for a long time in cervix and vagina, penis, anus and oropharynx (HPV 16 and 18 strains). The CDC observed that over 70 percent of infections in young females clear up within 12 months, while 90% do so within 24 months. There are 40 types of HPVs which are transmitted sexually, affecting ano-genital areas, the other types are transmitted by personal contact or indirect transmission from using untreated swimming pool, fomites etc. or by auto-inoculation. Persistent long-term HPV infection raises the risk of developing precancerous lesions of the cervix and other region. However, in the majority of cases, cancer can be prevented. Among different types, types 16, 18, 33, 35, 45, 51, 52, 56, 58, 59, 68, 73, and 82 can cause cancer they are carcinogenic and are sexually transmitted. The HPV virus enters the human body through a small cut, tear, or abrasion on the epidermis; the primary mode of transmission is through skin-to-skin contact. ","PeriodicalId":15418,"journal":{"name":"Journal of Clinical Dermatology","volume":"111 1","pages":"71-75"},"PeriodicalIF":0.0,"publicationDate":"2015-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80872778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-10-12DOI: 10.19070/2332-2977-1500018
R. Gandhi, C. Ulman, K. Kellawan, T. Olsen, J. Trevino, S. Krishnamurthy
A 71 year-old male veterinarian developed swelling and an erythematous eruption on his right 4th finger two weeks after receiving a puncture wound from the claw of a cat. The patient denied pain, pruritus, or ulceration, and review of systems was negative. Four weeks later, the patient developed tender right epicondylar lymphadenopathy. His primary care physician treated him empirically with multiple antibiotics including amoxicillin/clavulanic acid, doxycycline, and rifampin. His lymphadenopathy resolved; however, the rash persisted.
{"title":"Chronic Cutaneous Blastomycosis","authors":"R. Gandhi, C. Ulman, K. Kellawan, T. Olsen, J. Trevino, S. Krishnamurthy","doi":"10.19070/2332-2977-1500018","DOIUrl":"https://doi.org/10.19070/2332-2977-1500018","url":null,"abstract":"A 71 year-old male veterinarian developed swelling and an erythematous eruption on his right 4th finger two weeks after receiving a puncture wound from the claw of a cat. The patient denied pain, pruritus, or ulceration, and review of systems was negative. Four weeks later, the patient developed tender right epicondylar lymphadenopathy. His primary care physician treated him empirically with multiple antibiotics including amoxicillin/clavulanic acid, doxycycline, and rifampin. His lymphadenopathy resolved; however, the rash persisted.","PeriodicalId":15418,"journal":{"name":"Journal of Clinical Dermatology","volume":"66 1","pages":"68-70"},"PeriodicalIF":0.0,"publicationDate":"2015-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73760874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-09-28DOI: 10.19070/2332-2977-150003e
Tapia Fj
Dendritic cells are the first and only cells capable of inducing a primary immune response activating resting naïve T cells in secondary lymphoid tissues (ie. lymph nodes) from antigens that they capture in the epithelia. Dendritic cells are called immature when they are in the epithelium functioning as phagocytes, and mature when they act as antigen-presenting cells in the lymph nodes. In the study, the inoculation of dendritic cells pulsed with neoantigens produced a robust immune response in three adult patients with advanced cutaneous melanoma. These melanomas were IIIC, resected and had not responded to prior therapy with anti-CTLA-4 (Ipilimumab), which stimulates the proliferation and activation of T cells that facilitate the destruction of tumor cells.
{"title":"Toward a Melanoma Dendritic Cell Vaccine using Neoantigens","authors":"Tapia Fj","doi":"10.19070/2332-2977-150003e","DOIUrl":"https://doi.org/10.19070/2332-2977-150003e","url":null,"abstract":"Dendritic cells are the first and only cells capable of inducing a primary immune response activating resting naïve T cells in secondary lymphoid tissues (ie. lymph nodes) from antigens that they capture in the epithelia. Dendritic cells are called immature when they are in the epithelium functioning as phagocytes, and mature when they act as antigen-presenting cells in the lymph nodes. In the study, the inoculation of dendritic cells pulsed with neoantigens produced a robust immune response in three adult patients with advanced cutaneous melanoma. These melanomas were IIIC, resected and had not responded to prior therapy with anti-CTLA-4 (Ipilimumab), which stimulates the proliferation and activation of T cells that facilitate the destruction of tumor cells.","PeriodicalId":15418,"journal":{"name":"Journal of Clinical Dermatology","volume":"5 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2015-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75330707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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