Progressive Multifocal Leukoencephalopathy – Immune Reconstitution Inflammatory Syndrome (PMLIRIS) is the subacute onset of neurological deficits that appeared or was exacerbated after initiation antiretroviral therapy (ART) for treatment of PML. It is due to severe neuroinflammation with re-establishment of immuncompetence. Approximately 25% of patients with HIV and PML develop IRIS. Clinical trials on the treatment of PML-IRIS is lacking with only limited evidence supporting the use of investigative therapies such as corticosteroids and Maraviroc. We report a case of a 36-year old Filipino male, known hypertensive and diagnosed with HIV, who presented with memory problems. He was eventually treated as a case of PML-IRIS on the 3rd week after initiation of ART. He was treated with a course of intravenous Dexamethasone, oral Mefloquine and intravenous immunoglobulin, and ART was continued. Clinical outcome in our patient shows an overall improvement of symptoms and no deterioration of neurologic deficits.
{"title":"Unmasking the truth Progressive multifocal leukoencephalopathy immune reconstitution inflammatory syndrome PML IRIS in a 36 year old male with HIV","authors":"Jon Stewart Dy","doi":"10.55920/2771-019x/1459","DOIUrl":"https://doi.org/10.55920/2771-019x/1459","url":null,"abstract":"Progressive Multifocal Leukoencephalopathy – Immune Reconstitution Inflammatory Syndrome (PMLIRIS) is the subacute onset of neurological deficits that appeared or was exacerbated after initiation antiretroviral therapy (ART) for treatment of PML. It is due to severe neuroinflammation with re-establishment of immuncompetence. Approximately 25% of patients with HIV and PML develop IRIS. Clinical trials on the treatment of PML-IRIS is lacking with only limited evidence supporting the use of investigative therapies such as corticosteroids and Maraviroc. We report a case of a 36-year old Filipino male, known hypertensive and diagnosed with HIV, who presented with memory problems. He was eventually treated as a case of PML-IRIS on the 3rd week after initiation of ART. He was treated with a course of intravenous Dexamethasone, oral Mefloquine and intravenous immunoglobulin, and ART was continued. Clinical outcome in our patient shows an overall improvement of symptoms and no deterioration of neurologic deficits.","PeriodicalId":15420,"journal":{"name":"Journal of Clinical Images and Medical Case Reports","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136369738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The abuse of topical anesthetics and steroids is not uncommon. However, having an eye eviscerated is rare due to complications from abusing both topical eyedrops. We report a case of Left Eye (LE) severe corneal ulcer with panophthalmitis secondary to over-the-counter topical proparacaine and topical dexamethasone abuse
{"title":"Tropical paradise turns into a nightmare. A rare case of evisceration caused by the misuse of over-the-counter proparacaine and dexamethasone eye drops","authors":"Zunaina Embong","doi":"10.52768/2766-7820/2451","DOIUrl":"https://doi.org/10.52768/2766-7820/2451","url":null,"abstract":"The abuse of topical anesthetics and steroids is not uncommon. However, having an eye eviscerated is rare due to complications from abusing both topical eyedrops. We report a case of Left Eye (LE) severe corneal ulcer with panophthalmitis secondary to over-the-counter topical proparacaine and topical dexamethasone abuse","PeriodicalId":15420,"journal":{"name":"Journal of Clinical Images and Medical Case Reports","volume":"63 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139370300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Oropharyngeal Kaposi’s sarcoma in a non-immunosuppressed patient","authors":"E. Ja","doi":"10.52768/2766-7820/2449","DOIUrl":"https://doi.org/10.52768/2766-7820/2449","url":null,"abstract":"Kaposis sarcoma is a malignant tumor caused by the HHV-8. It usually occurs in people with weakened immune systems, due to HIV/AIDS","PeriodicalId":15420,"journal":{"name":"Journal of Clinical Images and Medical Case Reports","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139370502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Leprosy is a well-known disease (Hansens Disease) since the days of Sushruta and Charkas and is caused by Mycobacterium leprae. In Vedic reference, it is mentioned as Kusht Rog [1]
{"title":"Clinico-social case report of lepromatous leprosy in a rural area of Central India","authors":"Komal N Muneshwar","doi":"10.52768/2766-7820/2450","DOIUrl":"https://doi.org/10.52768/2766-7820/2450","url":null,"abstract":"Leprosy is a well-known disease (Hansens Disease) since the days of Sushruta and Charkas and is caused by Mycobacterium leprae. In Vedic reference, it is mentioned as Kusht Rog [1]","PeriodicalId":15420,"journal":{"name":"Journal of Clinical Images and Medical Case Reports","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139370475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lipoid necrobiosis is a rare granulomatous dermatosis, it usually occurs in diabetic subjects. Clinically, it presents as papules, nodules or erythematous plaques with a yellowish atrophic center, sometimes telangiectatic, and is located preferably at the pre-shin level. the confirmation of the diagnosis is based on the histology spectra which will find a granulomatous infiltrate arranged in palisades occupying the whole height of the dermis with an infiltrate composed of lymphocytes, histiocytes, plasma cells and epithelioid cells, as well as epithelioid cells and giant cells. Vascular lesions can be observed [1].
{"title":"Dermoscopy of lipoid necrobiosis","authors":"Oujdi Sabrina","doi":"10.55920/2771-019x/1458","DOIUrl":"https://doi.org/10.55920/2771-019x/1458","url":null,"abstract":"Lipoid necrobiosis is a rare granulomatous dermatosis, it usually occurs in diabetic subjects. Clinically, it presents as papules, nodules or erythematous plaques with a yellowish atrophic center, sometimes telangiectatic, and is located preferably at the pre-shin level. the confirmation of the diagnosis is based on the histology spectra which will find a granulomatous infiltrate arranged in palisades occupying the whole height of the dermis with an infiltrate composed of lymphocytes, histiocytes, plasma cells and epithelioid cells, as well as epithelioid cells and giant cells. Vascular lesions can be observed [1].","PeriodicalId":15420,"journal":{"name":"Journal of Clinical Images and Medical Case Reports","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135215715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oral Neural Crest-Derived Stem Cells (oNCSCs) are a type of adult stem cell that can be isolated from the oral cavity. These stem cells have the ability to differentiate into various cell types, including neurons, glial cells, and adipocytes. oNCSCs have been shown to play a crucial
{"title":"Characterization of oral-derived neural crest-derived stem cell populations (oNCSCs) in the teeth: Therapeutic potential for bone tissue engineering","authors":"Wolf-D Grimm","doi":"10.52768/2766-7820/2447","DOIUrl":"https://doi.org/10.52768/2766-7820/2447","url":null,"abstract":"Oral Neural Crest-Derived Stem Cells (oNCSCs) are a type of adult stem cell that can be isolated from the oral cavity. These stem cells have the ability to differentiate into various cell types, including neurons, glial cells, and adipocytes. oNCSCs have been shown to play a crucial","PeriodicalId":15420,"journal":{"name":"Journal of Clinical Images and Medical Case Reports","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139370566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Temporomandibular disorder (TMD) is a common musculoskeletal condition. Changes in diagnostic criteria followed the relevant changes in the understanding of the etiology of TMD. The Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) is a suite of validated instruments and guidelines for the most accurate and reliable diagnosis of various TMD-associated pathologies. This text reviews the leading DC/TMD questionnaire options, in either symptom checklists or psychosocial/functional sections.
{"title":"A brief comment about terminology and diagnostic standards in temporomandibular disorders","authors":"Ricardo Luiz de Barreto Aranha","doi":"10.55920/2771-019x/1457","DOIUrl":"https://doi.org/10.55920/2771-019x/1457","url":null,"abstract":"Temporomandibular disorder (TMD) is a common musculoskeletal condition. Changes in diagnostic criteria followed the relevant changes in the understanding of the etiology of TMD. The Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) is a suite of validated instruments and guidelines for the most accurate and reliable diagnosis of various TMD-associated pathologies. This text reviews the leading DC/TMD questionnaire options, in either symptom checklists or psychosocial/functional sections.","PeriodicalId":15420,"journal":{"name":"Journal of Clinical Images and Medical Case Reports","volume":"95 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135364173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Squamous cell carcinomas of Head and Neck are at a rising trend since recent years. Southeast Asia (especially the Indian subcontinent) is a high-risk region for these cancers. More than 200,000 new such cases are reported each year in India [1].
{"title":"A rare case of an inclusion cyst mimicking carcinoma unknown primary with secondary in the neck","authors":"J. Bakshi","doi":"10.52768/2766-7820/2448","DOIUrl":"https://doi.org/10.52768/2766-7820/2448","url":null,"abstract":"Squamous cell carcinomas of Head and Neck are at a rising trend since recent years. Southeast Asia (especially the Indian subcontinent) is a high-risk region for these cancers. More than 200,000 new such cases are reported each year in India [1].","PeriodicalId":15420,"journal":{"name":"Journal of Clinical Images and Medical Case Reports","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139370565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
It is about a 24-year-old male, with no past medical history, diagnosed in April 2021 with left testicular germ cell tumor. He had a left orchiectomy.
患者为24岁男性，既往无病史，于2021年4月确诊为左侧睾丸生殖细胞瘤。他做了左睾丸切除术。
{"title":"Lumbo Aortic lymphadenectomy for residual retroperitoneal masses in testicular germ cell tumors","authors":"Tlili Yassine","doi":"10.55920/2771-019x/1455","DOIUrl":"https://doi.org/10.55920/2771-019x/1455","url":null,"abstract":"It is about a 24-year-old male, with no past medical history, diagnosed in April 2021 with left testicular germ cell tumor. He had a left orchiectomy.","PeriodicalId":15420,"journal":{"name":"Journal of Clinical Images and Medical Case Reports","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135493808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
An 87-year-old woman was admitted to a public hospital in São Paulo, Brazil, with an extensive, ulcerated, infected lesion with bleeding on her face, along with a focus of myiasis. The lesion had appeared 15 years ago on the right malar region
{"title":"Squamous cell carcinoma of the face with a focus of myiasis","authors":"F. F. Naime","doi":"10.52768/2766-7820/2446","DOIUrl":"https://doi.org/10.52768/2766-7820/2446","url":null,"abstract":"An 87-year-old woman was admitted to a public hospital in São Paulo, Brazil, with an extensive, ulcerated, infected lesion with bleeding on her face, along with a focus of myiasis. The lesion had appeared 15 years ago on the right malar region","PeriodicalId":15420,"journal":{"name":"Journal of Clinical Images and Medical Case Reports","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139370610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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