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Effect of Lycopene on Pharmacokinetic and Pharmacodynamics of Gliclazide in Diabetic Animal Models 番茄红素对格列齐特在糖尿病动物模型中药动学和药效学的影响
Pub Date : 2018-09-28 DOI: 10.19080/jcmah.2018.08.555730
Umachandar Lagisetty
Background: Diabetes mellitus is one of the metabolic disorders associated with high blood sugar levels. Utilization of natural drugs among patients under diabetes mellitus pharmacotherapy is across the board. Objective: To examine the pk-pd(pharmacodynamic-pharmacokinetic) interactions of lycopene and gliclazide in animal models and to understand the safety & effectiveness. Methods: Single and multiple dose interaction studies were carried out in normal rats, diabetes induced rats and rabbits to evaluate the effect of lycopene on the gliclazide activity. Blood samples from the study animals were used for the estimation insulin and glucose levels by using radioimmunoassay method and chemistry analyzer (automated) respectively. Homeostasis model assessment used for determination of β-cell function. Additionally, sophisticated HP-LC technique used for analysis of diabetic rabbits serum samples for gliclazide. Results: Gliclazide produces significant reduction in blood glucose levels in diabetic animals. However, tests examined from gliclazide in blend with lycopene indicated more prominent diminishment in blood glucose concentration in animals with diabetes. Conclusion: The study concludes that the lycopene along with gliclazide shows the significant pharmacodynamics interaction, but doesn’t establish pharmacokinetics interaction up on single and multiple-dose treatment in animals.
背景:糖尿病是一种与高血糖相关的代谢性疾病。在接受糖尿病药物治疗的患者中,天然药物的使用是全面的。目的:观察番茄红素与格列齐特在动物模型上的药效学-药代动力学相互作用,了解其安全性和有效性。方法:采用正常大鼠、糖尿病大鼠和家兔进行单剂量和多剂量相互作用研究,评价番茄红素对格列齐特活性的影响。分别采用放射免疫法和化学分析仪(自动)测定研究动物的胰岛素和葡萄糖水平。用于测定β细胞功能的稳态模型评估。此外,采用高效液相色谱技术对糖尿病家兔血清样品进行格列齐特分析。结果:格列齐特能显著降低糖尿病动物的血糖水平。然而,格列齐特与番茄红素混合的试验表明,糖尿病动物的血糖浓度下降更为显著。结论:番茄红素与格列齐特的药效学相互作用显著,但在动物体内单剂量和多剂量均未建立药动学相互作用。
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引用次数: 1
Secondary Immune Deficiency (like Chemoterapy-Induced) Means no Vaccines 继发性免疫缺陷(如化疗引起的)意味着没有疫苗
Pub Date : 2018-09-28 DOI: 10.19080/jcmah.2018.08.555729
M. Kuman
Secondary immune deficiency is the immune deficiency caused by chemotherapy or other drugs taken for a long time [1]. It should be self-understanding that when the immune system is weakened by chemotherapy or prolonged usage of a drug or drugs, the doctor shouldn’t recommend immunizations because if the immune system is weaker, it should not be asked to deal with more and more new viruses, even when these viruses are weakened as they are in the vaccines.
继发性免疫缺陷是由于长期服用化疗或其他药物引起的免疫缺陷。当免疫系统因化疗或长期使用一种或多种药物而减弱时,医生不应该建议进行免疫接种,因为如果免疫系统较弱,就不应该要求它处理越来越多的新病毒,即使这些病毒在疫苗中被削弱了。
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引用次数: 0
Notes for Clinical Use of Extra Acupoints 额外穴位临床使用注意事项
Pub Date : 2018-09-26 DOI: 10.19080/JCMAH.2018.08.555728
T. Hong
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引用次数: 6
Regimenal Therapy a Drugless Regimen for Well Being of a Person in USM and its Important Place in the Mainstream Treatment of USM 方案治疗:超声心动图患者无药物治疗方案及其在超声心动图主流治疗中的重要地位
Pub Date : 2018-09-17 DOI: 10.19080/JCMAH.2018.08.555727
S. Firdaus
Regimenal therapy is such core method of treatment through which the morbid matter is eliminated or its excessive production is checked or its spread is arrested and resolved by certain special techniques and thereby restoring humoral equilibrium. There are various forms of such therapy with details of its applications. There are various forms of regimenal therapy which is dealt by al qanoon which details about its principals, objectives, indications, and contraindications method of applications with its adverse effects etc. some of them are purging, emesis, venesection, cupping, turkish bath, massage, exercises, leeching, diuresis, diaphoresis etc. [1].
方案疗法是一种核心的治疗方法,通过这种治疗方法,病态物质被消除,或其过量的产生被控制,或其扩散被阻止,并通过某些特殊的技术来解决,从而恢复体液平衡。有各种形式的这种治疗及其应用的细节。有各种形式的治疗方案,由al qanon处理,详细说明其原则,目标,适应症,禁忌症,应用方法及其副作用等,其中一些是泻,呕吐,静脉插管,拔罐,土耳其浴,按摩,运动,水蛭,利尿,出汗等。
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引用次数: 2
The Impact of Biofield Energy Treated Vitamin D3 on the Structural Crosslinks, Maturation, and Bone Mineralization in Human Bone Osteosarcoma Cells (MG-63) 生物场能量处理维生素D3对人骨肉瘤细胞结构交联、成熟和骨矿化的影响(MG-63)
Pub Date : 2018-08-31 DOI: 10.19080/JCMAH.2018.07.555725
A. Branton, M. Trivedi, Dahryn Trivedi, G. Nayak, S. Jana
Author(s): Branton, Alice; Trivedi, Mahendra Kumar; Trivedi, Dahryn; Nayak, Gopal; Jana, Snehasis | Abstract: The objective was to investigate the potential of Biofield Treated vitamin D3 and DMEM on bone markers. The test items (TIs) were separated into two parts. One part of each sample was received Consciousness Energy Treatment by Alice Branton and termed as Biofield Treated (BT) samples, while other parts of each sample denoted as untreated TI (UT). MTT data found TIs were safe and nontoxic at tested concentrations. ALP was significantly elevated by 390% and 200% in UT-DMEM + BT-TI at 0.1 and 1µg/mL, respectively; while, increased by 135.29% in BT-DMEM + BT-TI at 0.1µg/mL than UT-DMEM + UT-TI. ALP was significantly increased by 106.34%, 138.47%, and 212.68% in UT-DMEM + BT-TI, BT-DMEM + UT-TI, and BT-DMEM + BT-TI, respectively at 10µg/mL than untreated. Collagen was significantly increased by 288.68% and 106.96% in UT-DMEM + BT-TI and BT-DMEM + BT-TI, respectively at 10µg/mL than untreated. Further, collagen was significantly increased by 435.78% and 139.72% in UT-DMEM + BT-TI and BT-DMEM + UT-TI, respectively at 50µg/mL than untreated. Percent of bone mineralization was significantly increased by 299.13%, 239.91%, and 218.77% in BT-DMEM + BT-TI at 0.1, 1, and 10µg/mL, respectively than untreated. Besides, percent of bone mineralization was distinctly increased by 192.51% in BT-DMEM + UT-TI at 10µg/mL than untreated. Overall, Biofield Treated vitamin D3 remarkably improved bone parameters in MG-63 cells and could be an alternative to vitamin D3 deficiency and used various bone disorders viz. low bone density, osteoporosis, autoimmune and inflammatory diseases, stress management and prevention, and anti-aging by improving overall health.
作者:布兰顿,爱丽丝;Trivedi, Mahendra Kumar;Trivedi Dahryn;Nayak Gopal;摘要:目的探讨生物场处理的维生素D3和DMEM在骨标志物上的潜力。测试项目(TIs)分为两部分。每个样本的一部分由Alice Branton进行意识能量处理,称为生物场处理(BT)样本,而每个样本的其他部分表示为未经处理的TI (UT)。MTT数据发现,在测试浓度下,ti是安全无毒的。在0.1和1µg/mL时,UT-DMEM + BT-TI的ALP分别显著升高390%和200%;而在0.1µg/mL时,BT-DMEM + BT-TI比UT-DMEM + UT-TI增加135.29%。10µg/mL时,UT-DMEM + BT-TI、BT-DMEM + UT-TI和BT-DMEM + BT-TI组ALP分别较未处理组显著升高106.34%、138.47%和212.68%。10µg/mL时,UT-DMEM + BT-TI和BT-DMEM + BT-TI的胶原蛋白含量分别比未处理时显著增加288.68%和106.96%。50µg/mL时,UT-DMEM + BT-TI和BT-DMEM + UT-TI的胶原蛋白含量分别比未处理时显著增加435.78%和139.72%。当BT-DMEM + BT-TI浓度为0.1、1和10µg/mL时,骨矿化率分别比未处理组显著提高299.13%、239.91%和218.77%。10 μ g/mL BT-DMEM + UT-TI组骨矿化率较未处理组明显提高192.51%。总体而言,Biofield处理过的维生素D3显著改善了MG-63细胞的骨骼参数,可以替代维生素D3缺乏症,并通过改善整体健康来治疗各种骨骼疾病,如低骨密度、骨质疏松症、自身免疫性和炎症性疾病、压力管理和预防以及抗衰老。
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引用次数: 0
Observational Study: Cancer Cases Treated with Homeopathy in the Basque Country/Navarre between 2013 and 2015 观察性研究:2013年至2015年间巴斯克地区/纳瓦拉地区顺势疗法治疗的癌症病例
Pub Date : 2018-08-31 DOI: 10.19080/jcmah.2018.08.555726
Victoria Claramunt Palou
The Study included 50 women and 15 men aged between 11 and 85 years. There we 44 patients with advanced tumour disease and 21 with early-stage disease. Conventional cancer treatment was chosen by 64 patients and one of them chose homeopathy only. Four patients made important changes in their lifestyle, and 8 had bio-decoding sessions. All patients had taken homeopathic medicines as palliative care tailored to different stages of their disease. A single drug treatment was used in 18 cases, based on the entire case. Ten cases we treated by applying Banergi protocols and constitutional medicine, and 37 cases were treated with different successive or combined drugs, depending on the state of the patient at the time, with the Minotti protocol for palliative care being applied in 9 cases. The predominant homeopathic dilutions were centesimals. The great variability of medications used on each of the patients shows the individuality of patient symptoms with the same clinical diagnosis, as well as the great variability in the criteria of homeopathy doctors when establishes a therapeutic strategy. Homeopathy has helped to control the tumour disease (patient free of disease) in 10 cases of early stage cancer and 12 cases of advanced tumour disease. Homeopathy was only palliative in 7 cases of early-stage cancer, in 22 cases of advanced tumour disease, and in five other cancers without staging. Homeopathy did not work in one case of early stage cancer, in two cases of advanced tumour disease, and in one case without staging. There were 5 cases in which results could not be assessed at the time of the study. According to the subjective assessment by the homeopathic doctor, homeopathy contributed to the control of tumour disease (patient free of disease with biological and /or imaging tests) in 22 cases, it was palliative in 34 cases, 4 patients died, and 5 cases cannot yet be evaluated. According to the assessment by the patient, it helped to control and improve their quality of life in 55 cases and it does not help them at all in 5 cases. This observational study has enabled us to evaluate the effectiveness of our work in the context of our clinical reality and more accurately describe all parameters involved in the case, including conventional treatments and their impact. Patient opinion is part of the evaluation of the results and requires questionnaires that can be adapted and standardized. Homeopaths carry out their work within an ethical framework bound by civil responsibility and respect for patient autonomy, open to collaboration with the work of the other professionals with a common goal, which is none to cure, relieve the patient, and contribute to the advancement of knowledge.
这项研究包括50名女性和15名男性,年龄在11岁到85岁之间。晚期肿瘤44例,早期肿瘤21例。64例患者选择常规癌症治疗,其中1例仅选择顺势疗法。4名患者的生活方式发生了重大改变,8名患者进行了生物解码。所有患者都服用顺势疗法药物作为针对其疾病不同阶段的姑息治疗。在整个病例的基础上,对18例使用了单一药物治疗。10例采用Banergi方案和体质药物治疗,37例采用不同的连续或联合药物治疗,这取决于患者当时的状态,其中9例采用Minotti方案进行姑息治疗。顺势疗法的主要稀释剂是百万分之一。在每个病人身上使用的药物的巨大差异显示了相同临床诊断的病人症状的个性,以及顺势疗法医生在建立治疗策略时的标准的巨大差异。顺势疗法帮助控制了10例早期癌症患者和12例晚期肿瘤患者的肿瘤疾病(患者无疾病)。顺势疗法仅在7例早期癌症,22例晚期肿瘤疾病和5例其他没有分期的癌症中起到缓解作用。顺势疗法在一个早期癌症病例、两个晚期肿瘤疾病病例和一个没有分期的病例中不起作用。在研究时,有5个病例的结果无法评估。根据顺势疗法医生的主观评价,22例顺势疗法有助于控制肿瘤疾病(经生物和/或影像学检查,患者无疾病),34例起到缓解作用,4例死亡,5例尚无法评估。根据患者评价,对55例患者的生活质量有控制和改善作用,对5例患者没有任何帮助。这项观察性研究使我们能够在临床现实的背景下评估我们工作的有效性,并更准确地描述病例中涉及的所有参数,包括常规治疗及其影响。患者意见是评估结果的一部分,需要可以调整和标准化的问卷。顺势疗法医生在道德框架内开展工作,受公民责任和尊重患者自主权的约束,愿意与其他专业人士合作,共同的目标不是治愈、减轻患者的痛苦,而是促进知识的进步。
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引用次数: 0
Exploration of Antibacterial and Anti-inflammatory Activities of Premna integrifolia Plant Extracts in Bubaline Mastitis 百合花植物提取物对丁巴林性乳腺炎的抑菌抗炎作用研究
Pub Date : 2018-08-31 DOI: 10.19080/jcmah.2018.07.555724
R. P.
Mastitis in dairy animals is inflammatory reaction of the udder tissue against the invading microbial pathogens. Bacterial pathogens are majorly implicated in the mastitis of cows and buffaloes leading to major production losses in dairy animals resulting in huge economic losses to dairy farmers and industry [1]. Staphylococcus aureus and Escherichia coli are the major bacterial pathogens of bovine/bubaline mastitis [2]. However, the emergence of antimicrobial resistance in bacterial pathogens that cause mastitis in dairy animals is a cause of grave concern [3-5]. Also controlling the inflammation in mastitis is very essential as the persistent inflammation of mammary gland tissue may result in permanent unproductivity in dairy animals [6-7]. Mastitis is the most frequent reason for the use of antimicrobial drugs in dairy herds, which eventually has resulted in antimicrobial resistance [8].
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引用次数: 0
Phytochemical Analysis and Toxicity Evaluation of Acetone, Aqueous and Methanolic Leaf Extracts of Agapanthus praecox Willd 杨梅叶丙酮、水提物和甲醇提物的植物化学分析及毒性评价
Pub Date : 2018-08-29 DOI: 10.19080/JCMAH.2018.07.555722
Afolayan Aj
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引用次数: 4
Suboccipital Musculature - Morphology, Functions and Variants - An Update 枕下肌肉组织-形态,功能和变异-更新
Pub Date : 2018-08-29 DOI: 10.19080/JCMAH.2018.07.555721
R. Reinhardt
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引用次数: 0
Artemisia: A Medicinally Important Genus 蒿属:一个重要的药用属
Pub Date : 2018-08-29 DOI: 10.19080/jcmah.2018.07.555723
Afolayan Aj
The word ‘Artemisia’ comes from the ancient Greek word: ‘Artemis’=The Goddess (the Greek Queen Artemisia) and ‘absinthium’ = Unenjoyable or without sweetness comprises 400 species (~474) revered as ‘Worm wood’, ‘Mug word’, ‘Sagebrush’ or ‘Tarragon’ [1-2]. In the ancient time, the knowledge of herbal medicines were confined by a tribal community, practiced villagers, and priests but in the modern era, the popularity and faith in the bioactive containing herbal drugs have become widespread. Although, several synthetic drugs are available in market to treat various diseases and disorders but, they have side-effects. On the other hand, there is an increasing demand of the herbal medicines, scientist and pharmaceutical industries investigating phytochemical as they are safe, effective, cost effective, eco-friendly and free from deleterious effects without any side effects. Artemisia genus provides a promising cure for various diseases by containing antibacterial and antioxidant properties. Therefore, Artemisia genus prompted us to compile a review on the secondary metabolites and several phytochemical compounds characterized in its different species.
“蒿属”一词来自古希腊单词:“Artemis”=女神(希腊女王蒿)和“absinthium”=不愉快或没有甜味,包括400种(约474种),被称为“虫木”,“杯词”,“山艾草”或“龙蒿”[1-2]。在古代,草药的知识仅限于部落社区,实践的村民和牧师,但在现代,对含有生物活性的草药的普及和信仰已经变得普遍。虽然市场上有几种合成药物可以治疗各种疾病和失调,但它们都有副作用。另一方面,对草药的需求越来越大,科学家和制药行业研究植物化学物质,因为它们安全、有效、成本效益高、生态友好,没有任何副作用。青蒿属植物含有抗菌和抗氧化的特性,为多种疾病的治疗提供了有希望的治疗方法。因此,我们对青蒿属植物的次生代谢产物和不同种类的植物化学成分进行了综述。
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引用次数: 6
期刊
Journal of Complementary Medicine & Alternative Healthcare
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