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Antioxidant, Antimicrobial And Wound Healing Activity Of Salvadora persica Twig Extracts 萨尔瓦多嫩枝提取物的抗氧化、抗菌和伤口愈合活性
Pub Date : 2018-08-29 DOI: 10.19080/JCMAH.2018.07.555720
P. Tatke
Wound healing is an interaction of complex cascade of cellular and biochemical actions healing to the restoration of structural and functional integrity with regain of strength of injured tissues [1]. It involves continuous cell cell interaction and cell matrix interactions that allow the process to proceed in different overlapping phases including inflammation, wound contraction , re epithelialization, tissue remodeling and formation of granulation tissue with angiogenesis [2]. These events are regulated by several mediators including platelets, inflammatory cells, cytokines and growth factors, and matrix metalloproteinases and their inhibitors [3].
伤口愈合是一个复杂的细胞级联和生化作用的相互作用过程,从愈合到结构和功能完整性的恢复以及损伤组织的强度恢复[1]。它涉及到持续的细胞间相互作用和细胞基质相互作用,使得这一过程在不同的重叠阶段进行,包括炎症、伤口收缩、再上皮化、组织重塑和肉芽组织的形成以及血管生成[2]。这些事件受多种介质的调节,包括血小板、炎症细胞、细胞因子和生长因子、基质金属蛋白酶及其抑制剂[3]。
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引用次数: 7
An Instrument for Dimensional Diagnosis of a Child Constitution (ICC) Individualizing the Care for Children with Developmental Disorders 儿童体质维度诊断工具(ICC):对发育障碍儿童的个性化护理
Pub Date : 2018-08-28 DOI: 10.19080/jcmah.2018.07.555717
M. Niemeijer
Developmental disorders include a broad range of psychological and physical symptoms through which children differ from what is generally considered as normal. These neurodevelopmental disorders [1] have a pervasive effect on the child’s development; they may affect it permanently in multiple developmental domains. The following disorders are mostly included: language/speech, learning and motoric disorders, Autism Spectrum Disorder (ASD), Attention Deficit Hyperactivity Disorder (ADHD), Obsessive Compulsive Disorder, Conduct Disorder and tic disorders. Also, intellectual disabilities and genetic syndromes, like Down’s syndrome. There are clinicians who also consider early traumatic experiences that affect the development of the child’s capacity to build attachments with others as a developmental disorder [2].
发育障碍包括广泛的心理和身体症状,通过这些症状,儿童与一般认为正常的儿童有所不同。这些神经发育障碍[1]对儿童的发育有普遍影响;它们可能会在多个发展领域永久地影响它。主要包括以下障碍:语言/言语、学习和运动障碍、自闭症谱系障碍(ASD)、注意缺陷多动障碍(ADHD)、强迫症、品行障碍和抽动障碍。还有智力残疾和遗传综合症,比如唐氏综合症。也有临床医生认为,早期创伤经历会影响儿童与他人建立依恋关系的能力发展,这是一种发育障碍[2]。
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引用次数: 0
A Study on Acupuncture Treatment to Meniere’s disease 针刺治疗梅尼埃病的研究
Pub Date : 2018-08-28 DOI: 10.19080/jcmah.2018.07.555715
T. Hong
In general, most people in Taiwan present themselves to the medical doctors first when they are in need of medical treatments. Part of this fact is because there are not sufficient scientific researches to prove the effects of the traditional Chinese medicine (TCM), acupuncture, or acupressure. Compared to the current acupuncture developments in Taiwan, acupuncture has gained more and more popularity in the past 40 years and been considered “essential health benefits” and has been more commonly used for pain conditions than general medical problems or addiction management in the US [1].
一般来说,大多数台湾人在需要治疗的时候都会先去找医生。部分原因是没有足够的科学研究来证明中医(TCM)、针灸或指压疗法的效果。与台湾目前的针灸发展相比,在过去的40年里,针灸越来越受欢迎,被认为是“必不可少的健康益处”,在美国,针灸更常用于治疗疼痛,而不是一般的医疗问题或成瘾管理[1]。
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引用次数: 0
Pterocarpus marsupium and Gymnema Sylvestre Powder in Alleviation of Biochemical Abnormalities Associated with Human Type 2 Diabetes Mellitus 有袋蕨和匙羹藤粉减轻与2型糖尿病相关的生化异常
Pub Date : 2018-08-28 DOI: 10.19080/jcmah.2018.07.555718
G. Prasad
Type 2 diabetes mellitus is reaching epidemic proportions worldwide and is a complex metabolic disorder characterized by hyperglycemia and dysregulated lipid metabolism [1,2]. Abdominal obesity and dyslipidemia (increased triglycerides, high LDL-cholesterol and low HDL-cholesterol), and hypertension, as well as altered platelet function [3] are the major risk factors contributing to type 2 diabetes. The metabolic defects that underlie the development of type 2 diabetes may include islet β-cells dysfunction, hyperglucagonemia, elevated endogenous glucose production, development of peripheral insulin resistance, inflammation of adipose tissue, and dysregulation of adipokines production [4]. Chronic elevation of blood glucose which is a central factor in the production of reactive oxygen species (ROS) [5] which in turn promote cellular damage and contribute to the development and progression of diabetic complications, such as cardiovascular disease, nephropathy, retinal blindness, neuropathy, and peripheral gangrene [6]. The conventional allopathic drugs, sulfonylureas, meglitinides, biguanides, metformin, thiazolidinediones, miglitol, acarbose, etc. although effective [7], are associated with minor or major side effects on long term use [8]. Statins used in the treatment of dyslipidemia have their own limitations [9].
2型糖尿病是一种以高血糖和脂质代谢失调为特征的复杂代谢疾病,在世界范围内已达到流行程度[1,2]。腹部肥胖和血脂异常(甘油三酯升高、低密度脂蛋白胆固醇和高密度脂蛋白胆固醇)、高血压以及血小板功能改变[3]是导致2型糖尿病的主要危险因素。导致2型糖尿病的代谢缺陷可能包括胰岛β细胞功能障碍、高胰高血糖素血症、内源性葡萄糖生成升高、外周胰岛素抵抗、脂肪组织炎症和脂肪因子生成失调[4]。血糖的慢性升高是活性氧(ROS)产生的核心因素[5],而活性氧又会促进细胞损伤,并导致糖尿病并发症的发生和发展,如心血管疾病、肾病、视网膜失明、神经病变和周围坏疽[6]。常规对抗性药物磺脲类、美格列酮类、双胍类、二甲双胍类、噻唑烷二酮类、米格列醇类、阿卡波糖类等虽然有效[7],但长期使用副作用或大或小[8]。他汀类药物用于治疗血脂异常有其局限性[9]。
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引用次数: 0
In-Vitro Studies of Bio-Silver Nanoparticles in Cytotoxicity and Anti- Inflammatory 生物纳米银细胞毒性和抗炎作用的体外研究
Pub Date : 2018-08-28 DOI: 10.19080/JCMAH.2018.07.555719
S. Paul
Nowadays, nanotechnology is a most promising amphitheatre for generating new applications in biotechnology and Nanomedicine [1]. Among several nanoproducts, a most prominent nanoproduct is nano silver. Silver nanoparticles (AgNPs) have become increasingly popular as an antibiotic agent in textiles and wound dressings, medical devices and appliances, such as refrigerators and washing machines [2]. AgNPs have been used for antimicrobial, antifungal, antioxidant, anticancer, and anti-inflammatory effects [3].
如今,纳米技术是在生物技术和纳米医学中产生新应用的最有前途的舞台[1]。在几种纳米产品中,最突出的一种纳米产品是纳米银。银纳米颗粒(AgNPs)作为抗生素在纺织品和伤口敷料、医疗设备和电器(如冰箱和洗衣机)中越来越受欢迎[2]。AgNPs已被用于抗菌、抗真菌、抗氧化、抗癌和抗炎作用[3]。
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引用次数: 4
Acute Hydrothorax Diagnosed Through Scintigraphy in a Patient on Peritoneal Dialysis 腹膜透析患者急性胸水的闪烁显像诊断
Pub Date : 2018-08-28 DOI: 10.19080/JCMAH.2018.07.555716
C. Chao
Our patient, a 55-year-old woman, had a history of hypertension and chronic glomerulo-nephritis-related uremia. She had undergone peritoneal dialysis (PD) catheter insertion in September 2014 and started receiving continuous ambulatory peritoneal dialysis (CAPD) twice daily 1 month after catheter insertion. She experienced intermittent abdominal pain 3 months after the insertion. No fever or dyspnea were noted with the pain. However, a decrease in ultrafiltration volume or rate after the PD session was noted by the patient herself. A review of her medical history did not reveal recent trauma to the chest or previous diaphragmatic surgery. However, shortness of breath was noted 1 day later; hence, she presented to the emergency department (ED). Tachycardia (104bpm) and elevated blood pressure (185/111mmHg) were noted in triage, and her respiratory rate was 22 breaths/min with 98% oxygen saturation. No chest pain or abnormal findings in the electrocardiogram were noted during her ED stay. Laboratory results did not reveal leukocytosis or acidosis. A chest X-ray revealed a massive right-sided pleural effusion (Figure 1). Pleurocentesis was suggested, but the patient refused. We analyzed the dialysate instead of a sample of the pleural effusion fluid; no evidence of infection was found. We arranged lung perfusion scintigraphy, 5 mCi of Technetium99m macro aggregated albumin (Tc-99m MAA) was injected into the PD fluids, and a rapid accumulation of radioactivity in the right hemithorax was observed in the images recorded at 30 min and 1 h after PD (Figure 2). Thus, peritoneo-pleural communication (right side) caused by diaphragmatic defect was diagnosed. PD was discontinued immediately and videoassisted thoracic surgery with thoracoscopic diaphragmatic fundoplication and pleurodesis was provided 2 days later. The patient was discharged uneventfully without the recurrence of pleural effusions during a 3-month follow-up.
我们的病人,一位55岁的女性,有高血压和慢性肾小球肾炎相关尿毒症的病史。患者于2014年9月行腹膜透析(PD)置管,置管1个月后开始每日2次连续门诊腹膜透析(CAPD)。术后3个月出现间歇性腹痛。疼痛时无发热或呼吸困难。然而,患者自己注意到PD治疗后超滤体积或速率的下降。回顾病史未发现近期胸部创伤或既往膈肌手术。但1天后出现呼吸短促;因此,她来到了急诊科(ED)。分诊时发现心动过速(104bpm)、血压升高(185/111mmHg),呼吸频率22次/min,血氧饱和度98%。在她的急诊科住院期间,没有发现胸痛或心电图异常。实验室结果未见白细胞增多或酸中毒。胸部x线显示右侧大量胸腔积液(图1)。建议行胸膜穿刺术,但患者拒绝。我们分析了透析液而不是胸腔积液样本;没有发现感染的证据。我们安排肺灌注显像,将5 mCi Technetium99m宏聚集白蛋白(Tc-99m MAA)注射到PD液中,PD后30 min和1 h的图像显示右半胸放射性快速积聚(图2),诊断为膈肌缺损引起的腹膜-胸膜交通(右侧)。立即停止PD治疗,2天后进行胸腔镜下膈底折叠胸膜切除术。在3个月的随访中,患者顺利出院,无胸腔积液复发。
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引用次数: 0
Patients’ Attitudes towards Complementary and Alternative Medicine: A Cross-Sectional Study among Hypertensive Patients in Baghdad, Iraq 患者对补充和替代医学的态度:伊拉克巴格达高血压患者的横断面研究
Pub Date : 2018-08-24 DOI: 10.19080/JCMAH.2018.07.555713
I. Ibrahim
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引用次数: 4
The Science and Art of Homeopathy 顺势疗法的科学与艺术
Pub Date : 2018-08-24 DOI: 10.19080/jcmah.2018.07.555714
E. Das
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引用次数: 1
Generating Loco-Regional Heat Impact - Available Technologies: Their Specific Efficacy and Inherent Restrictions 产生局部区域热影响-可用技术:它们的特定功效和固有限制
Pub Date : 2018-08-24 DOI: 10.19080/JCMAH.2018.07.555711
H. Sahinbas
order to spread hyperthermia to a scalable supply for a population´s potential need. An awareness of realistic claims and restrictions of the various technologies is helpful in gaining realistic expectations and consecutively an acceptance among clinicians.
为了将热疗传播到可扩展的供应,以满足人群的潜在需求。对各种技术的现实要求和限制的认识有助于获得现实的期望和临床医生的接受。
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引用次数: 0
Fenugreek: A Miraculous Medicinal Herb 葫芦巴:一种神奇的草药
Pub Date : 2018-08-24 DOI: 10.19080/JCMAH.2018.07.555710
T. A. Dar
Saponins are amphipathic glycosides having hydrophilic glycoside moieties combined with a lipophilic triterpene derivative. The glycoside free (aglycone) portion of the saponin is termed as sapogenins. There are different sources of saponins and one of the chief source is fenugreek. Fenugreek contains approximately 4 to 8% saponins and about 1% alkaloids. The main steroidal sapogenins obtained from fenugreek seeds are diosgenin and yamogenin which are used as steroid intermediates in the pharmaceutical industry. The occurrence of diosgenin [(25R)-spirost-5-en-3β-ol] in the seeds of fenugreek has been well expected for over 50 years [15]. Other saponins and steroidal saponins present in fenugreek include fenugrin B, fenugreekine, trigofoenosides A-G, tigogenin, neotigogenin, gitogenin, neogitogenin, yuccagenin and saponaretin [16]. The plant alkaloid Trigonelline (0.3-0.4%) was first isolated from the seeds of fenugreek. it is a pyridine alkaloid, known for its hypoglycaemic and hypocholesterolemic activity. Trigonelline (N-methylnicotinic acid) is derived from nicotinic acid and the reaction is catalysed by S-adenosyl-L-methionine (SAM)dependent nicotinate enzyme N-methyltransferase. Nicotinamide and nicotinic acid, the products of pyridine nucleotide cycle (PNC) give rise to trigonelline. The synthesis of trigonelline from nicotinamide mononucleotide (NaMN) is shown in the Figure 2. Other alkaloids present n fenugreek include Choline, Gentianine, Carpaine and Betain [16-18].
皂苷是两亲性糖苷,具有亲水性糖苷部分和亲脂性三萜衍生物。皂苷中不含糖苷(苷元)的部分称为皂苷元。皂苷有不同的来源,其中一个主要来源是胡芦巴。胡芦巴含有约4%至8%的皂苷和约1%的生物碱。从胡芦巴种子中提取的主要甾体皂苷元是薯蓣皂苷元和山芋皂苷元,它们在制药工业中用作甾体中间体。在葫芦巴种子中发现薯蓣皂苷元[(25R)-spirost-5-en-3β-ol]已经有50多年的历史了[15]。胡芦巴中存在的其他皂苷和甾体皂苷包括胡芦巴苷B、胡芦巴苷元、三叶皂苷A-G、胡芦巴苷元、新胡芦巴苷元、胡芦巴苷元、新胡芦巴苷元、番石榴苷元和皂苷元[16]。葫芦巴种子中首次分离到葫芦巴碱(0.3 ~ 0.4%)。它是一种吡啶生物碱,以其降血糖和降胆固醇活性而闻名。Trigonelline (n -甲基烟酸)是由烟酸衍生而来,该反应是由s -腺苷- l-蛋氨酸(SAM)依赖的烟酸酶n -甲基转移酶催化的。吡啶核苷酸循环(PNC)的产物烟酰胺和烟酸生成葫芦巴碱。烟酰胺单核苷酸(NaMN)合成葫芦巴碱的过程如图2所示。胡芦巴中存在的其他生物碱包括胆碱、龙胆碱、车碱和甜菜碱[16-18]。
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引用次数: 2
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Journal of Complementary Medicine & Alternative Healthcare
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